Pacific 8 Ventures

Certainly Health operates a healthcare marketplace that enables insured patients to compare guaranteed out-of-pocket costs across various doctors and services. By integrating insurance details, such as remaining deductibles, coinsurance, copay, and benefits, with up-to-date negotiated rates data, the platform calculates potential out-of-pocket expenses for patients. This approach not only offers price protection but also empowers users to make informed decisions regarding their healthcare options based on affordable rates. Through this service, Certainly Health aims to enhance transparency in healthcare pricing and improve access to cost-effective medical services.

BillionToOne Inc. is a precision diagnostics company based in Menlo Park, California, that specializes in molecular testing for prenatal and oncology applications. Established in 2016, the company has developed a patented molecular counter platform capable of detecting and quantifying DNA molecules at an extraordinarily precise level. BillionToOne's flagship product, UNITY, is a noninvasive prenatal screening test that analyzes fetal cell-free DNA from a simple blood sample taken from the mother, allowing for the detection of single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and beta-thalassemia. This innovative approach aims to replace more invasive procedures like amniocentesis, providing a safer and more affordable alternative for expecting mothers, particularly in developing countries. Additionally, the company is focused on oncology, offering tests that can accurately identify actionable mutations and assess tumor burden through blood samples.

Fauna Bio Incorporated is a biotechnology company based in San Francisco, California, founded in 2018. It specializes in developing a cross-mammal drug discovery platform aimed at treating human diseases, including heart disease and neurodegenerative disorders. By studying the mechanisms that allow certain animals, such as hibernating and deep-diving species, to withstand extreme conditions, Fauna Bio seeks to uncover insights that can enhance human health. The company utilizes animal genomics, transcriptomics, metabolomics, and proteomics data from a diverse range of species to identify novel drug targets and facilitate pre-clinical and early clinical testing of new therapeutics. Through its innovative approach, Fauna Bio aims to improve recovery from serious medical events like trauma, heart attacks, and strokes.

BillionToOne Inc. is a precision diagnostics company based in Menlo Park, California, that specializes in molecular testing for prenatal and oncology applications. Established in 2016, the company has developed a patented molecular counter platform capable of detecting and quantifying DNA molecules at an extraordinarily precise level. BillionToOne's flagship product, UNITY, is a noninvasive prenatal screening test that analyzes fetal cell-free DNA from a simple blood sample taken from the mother, allowing for the detection of single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and beta-thalassemia. This innovative approach aims to replace more invasive procedures like amniocentesis, providing a safer and more affordable alternative for expecting mothers, particularly in developing countries. Additionally, the company is focused on oncology, offering tests that can accurately identify actionable mutations and assess tumor burden through blood samples.

Hi.health is focused on transforming the claims process in private health insurance by addressing inefficiencies and enhancing cost control for insurers. The company offers a solution that includes co-branded debit cards for insurance members, allowing them to access health-related services without incurring out-of-pocket expenses. This approach not only simplifies the user experience but also provides insurers with structured data and real-time visibility into claims costs, helping to minimize fraud and operational expenses. Additionally, the platform manages invoices and prescriptions, further streamlining the insurance process and encouraging cost-conscious behavior among members. Through these innovations, Hi.health aims to deliver significant improvements in user satisfaction and substantial cost savings for insurers.

Mammoth Biosciences, Inc. is a biotechnology company based in South San Francisco, California, that focuses on developing innovative CRISPR solutions for a variety of applications. The company offers DETECTR™, a diagnostic platform that identifies specific nucleic acids in samples, aiding in the detection of diseases such as bacterial infections, cancer, and viral infections. Additionally, Mammoth Biosciences provides CRISPR-Cas systems for genome editing, targeting therapeutic areas including immuno-oncology, autoimmune diseases, and liver diseases. By harnessing proprietary ultracompact proteins and leveraging advanced research and development, Mammoth aims to create affordable point-of-care tests and enhance diagnostics across healthcare, agriculture, and environmental monitoring. Co-founded by CRISPR pioneer Jennifer Doudna, the company has attracted significant investment from institutional and individual backers.

Fauna Bio Incorporated is a biotechnology company based in San Francisco, California, founded in 2018. It specializes in developing a cross-mammal drug discovery platform aimed at treating human diseases, including heart disease and neurodegenerative disorders. By studying the mechanisms that allow certain animals, such as hibernating and deep-diving species, to withstand extreme conditions, Fauna Bio seeks to uncover insights that can enhance human health. The company utilizes animal genomics, transcriptomics, metabolomics, and proteomics data from a diverse range of species to identify novel drug targets and facilitate pre-clinical and early clinical testing of new therapeutics. Through its innovative approach, Fauna Bio aims to improve recovery from serious medical events like trauma, heart attacks, and strokes.

Bunkerhill Health is a collective of academic institutions focused on the development, testing, and implementation of artificial intelligence algorithms tailored for the healthcare sector. The organization provides a robust technology platform that includes a training data consortium and a clinical trials network, facilitating the management of healthcare databases through AI. Its infrastructure enables researchers from hospitals, university laboratories, and the healthcare industry to efficiently train, test, and deploy their AI models within clinical environments. By streamlining these processes, Bunkerhill Health aims to enhance the integration of artificial intelligence in healthcare practices.

Hint Health Inc. is a San Francisco-based company that specializes in developing a membership management platform tailored for direct care providers. Founded in 2013 by Zak Holdsworth and Graham Melcher, Hint Health offers tools that facilitate membership administration and billing, enabling healthcare providers to operate and manage their own plans effectively. This platform supports a range of offerings, including essential, plus, pro, and enterprise plans, allowing organizations to design and implement direct primary care programs. By empowering providers to compete directly with traditional insurance models, Hint Health aims to transform the healthcare system, enhancing cost efficiency, quality of care, and patient outcomes. The company also hosts the Hint Summit, a conference that gathers healthcare professionals and industry leaders to discuss and promote healthcare reform in the United States.

BillionToOne Inc. is a precision diagnostics company based in Menlo Park, California, that specializes in molecular testing for prenatal and oncology applications. Established in 2016, the company has developed a patented molecular counter platform capable of detecting and quantifying DNA molecules at an extraordinarily precise level. BillionToOne's flagship product, UNITY, is a noninvasive prenatal screening test that analyzes fetal cell-free DNA from a simple blood sample taken from the mother, allowing for the detection of single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and beta-thalassemia. This innovative approach aims to replace more invasive procedures like amniocentesis, providing a safer and more affordable alternative for expecting mothers, particularly in developing countries. Additionally, the company is focused on oncology, offering tests that can accurately identify actionable mutations and assess tumor burden through blood samples.

Karius, Inc. is a life sciences company based in Redwood City, California, specializing in genomic insights for infectious diseases. The company offers a non-invasive blood test known as the Karius Test, which utilizes sequencing of microbial cell-free DNA to identify and quantify various pathogens, including bacteria, DNA viruses, fungi, and parasites. This test is particularly useful for diagnosing complicated pneumonia, infections in immunocompromised patients, and endocarditis. By mapping the microbial landscape of each patient from a single blood draw, Karius aims to assist clinicians in making rapid and informed treatment decisions. The company's laboratory is CLIA-certified and CAP-accredited, ensuring high standards in clinical laboratory testing. Additionally, Karius provides laboratory services for pathogen biomarker detection tailored to biopharmaceutical companies.

Multiply Labs specializes in the production of personalized pharmaceutical capsules that cater to the unique needs of individual patients. The company leverages a combination of pharmaceutical science and advanced robotics technology to create these tailor-made capsules. Its innovative approach includes operating a state-of-the-art robotic manufacturing facility, which allows for the efficient production of individualized drugs at a reduced cost. Multiply Labs stands out as a pioneer in the industry, being the first to introduce 3D printed capsules, thereby transforming how medications are customized to meet the specific metabolic requirements of patients.

Wellthie Inc. is an insurance technology company based in New York, founded in 2013, that aims to modernize the insurance shopping experience. It provides a cloud-based e-commerce platform designed to simplify the distribution of insurance for small businesses and individuals. Wellthie's platform features tools for broker and carrier shopping, including medical and ancillary quotes, a broker management dashboard, modeling and scenario planning, and custom client proposals. Additionally, it offers a national small group benefits marketplace that helps brokers optimize sales and allows carriers to enhance product distribution. By delivering an intuitive shopping experience, Wellthie enables insurance professionals to increase sales across various insurance lines while assisting small businesses in finding suitable health insurance options online.

Quantified Care is a developer of a multimedia software platform focused on chronic care and post-discharge management. The platform provides tools for both patients and clinical management teams, allowing patients to receive personalized updates and feedback based on their symptoms, medication, and vital signs through their preferred communication methods, such as mobile apps, voice assistants, texts, phone calls, or web portals. Data is collected either manually or automatically from connected devices and wearables. While patients benefit from tailored support, clinical teams utilize analytics to categorize patients into high, medium, and low-risk tiers via Quantified Care’s clinical intelligence engine. This system triggers alerts for key clinical resources to take timely action and includes a secure communication layer to facilitate remote patient engagement, ultimately enhancing the quality of care delivered by healthcare providers.

Labdoor, Inc. is a company based in South San Francisco, California, that specializes in the online sale of dietary supplements and energy drinks. The product range includes fish oils, herbal supplements, magnesium, melatonin, probiotics, protein, and zinc supplements. Labdoor operates as a testing laboratory that verifies the quality of consumer products, particularly supplements. Through its website, Labdoor.com, consumers can access scientific reviews of products and shop for those that have undergone rigorous testing for purity and potency. The company offers a "Labdoor Certified" program for manufacturers who submit their products for quality control testing, ensuring that consumers receive reliable information about what they are purchasing. Labdoor publishes detailed reports and grades on various products, enabling consumers to make informed decisions about their health and supplement needs.

Cohero Health, Inc. is a digital respiratory health company that focuses on improving the management of asthma and chronic obstructive pulmonary disease (COPD). Founded in 2012 and based in New York, the company offers a proprietary connected health platform that combines sensor-based technology with a mobile application. This platform includes the BreatheSmart app, which provides customized medication reminders, records inhaler usage, and tracks lung function, symptoms, and environmental conditions over time. Cohero Health's product suite features mSpirometer lung function sensors and HeroTracker, a Bluetooth-enabled inhaler tracker that monitors both control and rescue medications. Additionally, BreatheSmart Connect serves as a Software-as-a-Service solution for remote patient monitoring and communication, enhancing coordination between patients and healthcare providers. By utilizing these tools, Cohero Health aims to improve medication adherence and overall health outcomes for individuals with respiratory conditions.

Hint Health Inc. is a San Francisco-based company that specializes in developing a membership management platform tailored for direct care providers. Founded in 2013 by Zak Holdsworth and Graham Melcher, Hint Health offers tools that facilitate membership administration and billing, enabling healthcare providers to operate and manage their own plans effectively. This platform supports a range of offerings, including essential, plus, pro, and enterprise plans, allowing organizations to design and implement direct primary care programs. By empowering providers to compete directly with traditional insurance models, Hint Health aims to transform the healthcare system, enhancing cost efficiency, quality of care, and patient outcomes. The company also hosts the Hint Summit, a conference that gathers healthcare professionals and industry leaders to discuss and promote healthcare reform in the United States.