Pacific 8 Ventures

Certainly Health operates a digital healthcare marketplace that enables insured patients to compare guaranteed out-of-pocket costs for various medical services across different providers. The platform combines patients' insurance information with recently published negotiated rates data to generate transparent, personalized cost estimates, empowering users to make informed decisions about their healthcare choices and book appointments at affordable prices.

BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Fauna Bio Incorporated is a biotechnology company based in San Francisco, California, that focuses on developing a cross-mammal drug discovery platform aimed at treating human diseases. Established in 2018 by a team of scientists with expertise in non-model organisms, the company investigates the biological mechanisms found in hibernating and deep-diving animals to uncover potential therapeutic applications for conditions such as heart disease and neurodegenerative disorders. By leveraging data from a diverse range of species, Fauna Bio aims to identify novel drug targets and facilitate pre-clinical and early clinical testing for new therapeutics, ultimately helping humans recover from serious medical emergencies like trauma, heart attacks, and strokes.

BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Hi.health is a company focused on transforming the claims process in private health insurance by addressing inefficiencies and enhancing user experience. It offers a health insurance application that integrates secure payment methods with a range of digital services, including invoice and prescription management. By providing co-branded debit cards to insurers' members, Hi.health eliminates out-of-pocket expenses, allowing users to access health-related facilities globally. The platform delivers real-time data, reducing claims lag and operational costs while minimizing fraud. Additionally, it implements a rewards program to encourage cost-effective behavior among users. Ultimately, Hi.health aims to significantly improve the user experience for insurance members while helping insurers achieve substantial cost savings.

Mammoth Biosciences, Inc. is a biotechnology company based in South San Francisco, California, founded in 2017 by CRISPR pioneer Jennifer Doudna and other key innovators. The company specializes in developing advanced CRISPR technologies, including its proprietary DETECTR platform, which enables the rapid detection of specific nucleic acids associated with various diseases. This platform facilitates diagnostic applications such as cancer screening, bacterial infections, and viral infections, allowing for real-time and simultaneous testing of multiple conditions. In addition to diagnostics, Mammoth Biosciences works on genome editing solutions for therapeutic purposes, targeting areas such as immuno-oncology, autoimmune diseases, and liver disorders. The company aims to democratize disease detection and enhance life science research through innovative, affordable, and efficient tools, while also leveraging its exclusive licensing of various Cas proteins for improved diagnostics and therapeutic applications.

Fauna Bio Incorporated is a biotechnology company based in San Francisco, California, that focuses on developing a cross-mammal drug discovery platform aimed at treating human diseases. Established in 2018 by a team of scientists with expertise in non-model organisms, the company investigates the biological mechanisms found in hibernating and deep-diving animals to uncover potential therapeutic applications for conditions such as heart disease and neurodegenerative disorders. By leveraging data from a diverse range of species, Fauna Bio aims to identify novel drug targets and facilitate pre-clinical and early clinical testing for new therapeutics, ultimately helping humans recover from serious medical emergencies like trauma, heart attacks, and strokes.

Bunkerhill Health is a collaborative organization comprised of academic institutions focused on advancing healthcare through the development and application of artificial intelligence technologies. The company specializes in creating AI algorithms designed to manage healthcare databases for clinical purposes. Its offerings include a training data consortium, a clinical trials network, and a distribution platform, which collectively facilitate the rapid and efficient training, testing, and deployment of AI models in hospital settings. By partnering with hospitals, university laboratories, and industry researchers, Bunkerhill Health aims to enhance the integration of artificial intelligence into clinical practice, ultimately improving patient care and outcomes.

Hint Health Inc. is a San Francisco-based company that specializes in developing a membership management platform tailored for direct care providers. Founded in 2013 by Zak Holdsworth and Graham Melcher, Hint Health offers tools that facilitate membership administration and billing, enabling healthcare providers to operate and manage their own plans effectively. This platform supports a range of offerings, including essential, plus, pro, and enterprise plans, allowing organizations to design and implement direct primary care programs. By empowering providers to compete directly with traditional insurance models, Hint Health aims to transform the healthcare system, enhancing cost efficiency, quality of care, and patient outcomes. The company also hosts the Hint Summit, a conference that gathers healthcare professionals and industry leaders to discuss and promote healthcare reform in the United States.

BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Karius, Inc. is a life sciences company based in Redwood City, California, with an additional office in Menlo Park. Founded in 2014, Karius specializes in generating genomic insights for infectious diseases through its innovative Karius Test. This non-invasive blood test utilizes sequencing of microbial cell-free DNA to identify and quantify a wide range of pathogens, including bacteria, DNA viruses, fungi, and parasites. The Karius Test is particularly useful in the diagnosis of complicated pneumonia, infections in immunocompromised patients, and endocarditis, enabling clinicians to make rapid and informed treatment decisions. Karius operates a CLIA-certified and CAP-accredited laboratory, providing high-complexity clinical laboratory testing and offering services for pathogen biomarker detection aimed at biopharmaceutical companies. The company is dedicated to advancing the understanding and management of infectious diseases, striving for a future where these conditions pose less of a threat to human health.

Multiply Labs is a pioneer in the field of personalized pharmaceuticals, specializing in the manufacturing of tailor-made capsules that cater to the unique needs of individual patients. By integrating advanced robotics technology with pharmaceutical science, the company has developed a unique robotic manufacturing facility capable of producing these customized capsules efficiently and cost-effectively. Multiply Labs stands out as the first company to introduce 3D printed capsules to the market, positioning itself at the forefront of innovation in individualized drug delivery. This approach allows for the creation of capsules that align with the specific metabolic requirements of patients, ultimately enhancing the effectiveness of pharmaceutical treatments.

Wellthie Inc. is an insurance technology company based in New York, founded in 2013. It specializes in providing tools for brokers and carriers to streamline the insurance distribution process for small businesses and individuals. Wellthie offers a cloud-based e-commerce platform that includes features such as medical and ancillary quotes, a broker management dashboard, scenario modeling, an online storefront, custom client proposals, and market insights. The company has created a national small group benefits marketplace, enabling brokers to enhance their small group sales and insurance carriers to optimize product distribution. By focusing on improving the insurance shopping experience, Wellthie aims to facilitate a more intuitive and efficient process for both brokers and clients.

Quantified Care is a developer of a multimedia software platform focused on chronic care and post-discharge management. The platform provides tools that enable personalized updates and feedback for patients, based on the collection of symptoms, medication, and vital data through regular check-ins, which can be delivered via mobile app, voice assistants, text, phone call, or web portal. Data can be obtained both manually and passively from connected devices and wearables. While patients benefit from tailored support, clinical management teams utilize analytics that categorize patient risk levels into high, medium, and low tiers through the company's clinical intelligence engine. This system also triggers alerts for healthcare professionals, ensuring timely intervention, while a secure communication layer enhances remote patient engagement for more effective health management.

Labdoor, Inc. is a company based in South San Francisco, California, that specializes in the online sale of dietary supplements and energy drinks. Founded in 2012, Labdoor offers a comprehensive testing and rating service for these products, focusing on their purity and potency. The company operates a chemistry lab where it conducts detailed analyses of various supplements, including fish oils, herbal supplements, and protein supplements, among others. Labdoor provides consumers with scientific reviews and rankings of these products, which are available on its website. Additionally, the company offers a "Labdoor Certified" program for manufacturers that submit their products for quality control testing, ensuring that consumers can confidently choose supplements that meet their health needs without harmful ingredients or contaminants.

Cohero Health, Inc. is a digital respiratory health company that focuses on developing solutions for the management of asthma and chronic obstructive pulmonary disease. The firm offers a connected health platform that includes the BreatheSmart app, which provides personalized reminders for medication adherence, tracks inhaler usage, measures lung function, and monitors symptoms and environmental conditions. Cohero Health also supplies mSpirometer lung function sensors and HeroTracker, a Bluetooth-enabled inhaler tracker for both control and rescue medications. Additionally, the company offers BreatheSmart Connect, a Software-as-a-Service solution that facilitates remote monitoring and communication between patients and healthcare providers. Founded in 2012 and headquartered in New York, Cohero Health operates as a subsidiary of AptarGroup, Inc.

Hint Health Inc. is a San Francisco-based company that specializes in developing a membership management platform tailored for direct care providers. Founded in 2013 by Zak Holdsworth and Graham Melcher, Hint Health offers tools that facilitate membership administration and billing, enabling healthcare providers to operate and manage their own plans effectively. This platform supports a range of offerings, including essential, plus, pro, and enterprise plans, allowing organizations to design and implement direct primary care programs. By empowering providers to compete directly with traditional insurance models, Hint Health aims to transform the healthcare system, enhancing cost efficiency, quality of care, and patient outcomes. The company also hosts the Hint Summit, a conference that gathers healthcare professionals and industry leaders to discuss and promote healthcare reform in the United States.