Pacific 8 Ventures

Certainly Health operates a digital healthcare marketplace that enables insured patients to compare guaranteed out-of-pocket costs for various medical services across different providers. The platform combines patients' insurance information with recently published negotiated rates data to generate transparent, personalized cost estimates, empowering users to make informed decisions about their healthcare choices and book appointments at affordable prices.

BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Fauna Bio develops a cross-mammal drug discovery platform that leverages biology from hibernating and other non-model animals to identify mechanisms that protect against injury and disease. By integrating genomics, transcriptomics, metabolomics, and proteomics across hundreds of species, the company identifies novel drug targets and advances therapeutics for conditions such as heart attack, stroke, neurodegenerative diseases, and other serious human illnesses. Founded by scientists in 2018, it is based in San Francisco. The approach aims to translate natural protective biology into preclinical and early clinical testing to enable recovery from emergency medical conditions.

BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

hi.health is a health‑insurance technology company that streamlines the claims process for private insurers. It offers co‑branded debit cards that members can use worldwide at health‑related facilities, eliminating out‑of‑pocket expenses and reducing claim friction. The platform aggregates digital services, invoices, and prescriptions, providing insurers with real‑time data, structured cost visibility, and fraud controls. By integrating payment and insurance functions, hi.health helps insurers improve member experience, cut operational and fraudulent costs, and encourage cost‑conscious behavior through reward and cashback programs.

Mammoth Biosciences harnesses diverse CRISPR systems for various applications. It offers DETECTR™ for nucleic acid detection in diseases like cancer and infections, and CRISPR-Cas systems for therapeutic genome editing in immuno-oncology, autoimmune diseases, and liver disorders. Its solutions span healthcare, agriculture, environmental monitoring, biodefense, and other sectors.

Fauna Bio develops a cross-mammal drug discovery platform that leverages biology from hibernating and other non-model animals to identify mechanisms that protect against injury and disease. By integrating genomics, transcriptomics, metabolomics, and proteomics across hundreds of species, the company identifies novel drug targets and advances therapeutics for conditions such as heart attack, stroke, neurodegenerative diseases, and other serious human illnesses. Founded by scientists in 2018, it is based in San Francisco. The approach aims to translate natural protective biology into preclinical and early clinical testing to enable recovery from emergency medical conditions.

Bunkerhill Health is a collaboration of academic institutions focused on developing, testing, and deploying artificial intelligence in healthcare. The organization builds and applies AI algorithms to clinical data and operates a training data consortium, a clinical trials network, and a distribution platform to enable hospitals, university labs, and industry researchers to train, validate, and deploy AI models within hospital environments.

Founded in 2013, Hint Health develops a comprehensive platform for direct care providers. Its tools automate membership management, billing, and offer an integrated electronic medical record system, enabling providers to efficiently deliver patient-centered care while competing directly with insurance-based models.

BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Karius is a life sciences company that develops genomic insights for infectious diseases. Its core offering, the Karius Test, is a non-invasive blood test that sequences microbial cell-free DNA to identify and quantify pathogens—including bacteria, DNA viruses, fungi, and parasites—for use in complicated pneumonia, infections in immunocompromised patients, and endocarditis. The company also provides laboratory services for pathogen biomarker detection for biopharmaceutical research and development. Founded in 2014, Karius is headquartered in Redwood City, California, with an additional office in Menlo Park, California. The laboratory operations are CLIA-certified and CAP-accredited, enabling high-complexity clinical testing. By mapping a patient’s microbial landscape from a single blood draw, Karius aims to support rapid, informed treatment decisions.

Multiply Labs develops robotic-enabled manufacturing for personalized pharmaceutical capsules, combining pharmaceutical science with robotics to produce tailor-made capsules that align with individual patient metabolic needs. The company operates a robotic manufacturing facility and has introduced 3D-printed capsules, aiming to address scaling challenges in biotech and improve the efficiency and cost of producing patient-specific medicines.

Wellthie Inc. is an insurance technology company based in New York, founded in 2013. It specializes in providing tools for brokers and carriers to streamline the insurance distribution process for small businesses and individuals. Wellthie offers a cloud-based e-commerce platform that includes features such as medical and ancillary quotes, a broker management dashboard, scenario modeling, an online storefront, custom client proposals, and market insights. The company has created a national small group benefits marketplace, enabling brokers to enhance their small group sales and insurance carriers to optimize product distribution. By focusing on improving the insurance shopping experience, Wellthie aims to facilitate a more intuitive and efficient process for both brokers and clients.

Quantified Care is a developer of a multimedia software platform focused on chronic care and post-discharge management. The platform provides tools that enable personalized updates and feedback for patients, based on the collection of symptoms, medication, and vital data through regular check-ins, which can be delivered via mobile app, voice assistants, text, phone call, or web portal. Data can be obtained both manually and passively from connected devices and wearables. While patients benefit from tailored support, clinical management teams utilize analytics that categorize patient risk levels into high, medium, and low tiers through the company's clinical intelligence engine. This system also triggers alerts for healthcare professionals, ensuring timely intervention, while a secure communication layer enhances remote patient engagement for more effective health management.

Labdoor, Inc. is a company based in South San Francisco, California, that specializes in the online sale of dietary supplements and energy drinks. Founded in 2012, Labdoor offers a comprehensive testing and rating service for these products, focusing on their purity and potency. The company operates a chemistry lab where it conducts detailed analyses of various supplements, including fish oils, herbal supplements, and protein supplements, among others. Labdoor provides consumers with scientific reviews and rankings of these products, which are available on its website. Additionally, the company offers a "Labdoor Certified" program for manufacturers that submit their products for quality control testing, ensuring that consumers can confidently choose supplements that meet their health needs without harmful ingredients or contaminants.

Cohero Health, Inc. is a digital respiratory health company that focuses on developing solutions for the management of asthma and chronic obstructive pulmonary disease. The firm offers a connected health platform that includes the BreatheSmart app, which provides personalized reminders for medication adherence, tracks inhaler usage, measures lung function, and monitors symptoms and environmental conditions. Cohero Health also supplies mSpirometer lung function sensors and HeroTracker, a Bluetooth-enabled inhaler tracker for both control and rescue medications. Additionally, the company offers BreatheSmart Connect, a Software-as-a-Service solution that facilitates remote monitoring and communication between patients and healthcare providers. Founded in 2012 and headquartered in New York, Cohero Health operates as a subsidiary of AptarGroup, Inc.

Founded in 2013, Hint Health develops a comprehensive platform for direct care providers. Its tools automate membership management, billing, and offer an integrated electronic medical record system, enabling providers to efficiently deliver patient-centered care while competing directly with insurance-based models.