Manifest
Pre Seed Round in 2025
Manifest is the simplest way for investors worldwide to access institutional-grade U.S. real estate through onchain ownership.
Shuttle Labs
Seed Round in 2024
Lore is developing the network and consumer tooling to onboard the next 1B users.
Fission Labs
Pre Seed Round in 2024
Fission Labs democratize access to VC investing by creating a global, liquid, on-chain marketplace.
OpenGradient
Seed Round in 2024
OpenGradient is a decentralized AI platform that hosts open-source models, enables secure inference, and supports deployment of AI applications. It provides native model hosting, permissionless composability, and secure execution to accelerate open-source AI while improving verifiability and enabling censorship-resistant model access. The platform relies on a heterogeneous AI compute architecture and a proprietary library to power secure AI workflows, including inference, agentic reasoning, and analysis. A web portal and SDK let developers leverage the AI stack without blockchain complexity, helping them build secure, auditable workflows. OpenGradient aims to democratize model ownership and promote transparency in AI by enabling scalable, verifiable computing across open-source models.
OpenGradient
Seed Round in 2024
OpenGradient is a decentralized AI platform that hosts open-source models, enables secure inference, and supports deployment of AI applications. It provides native model hosting, permissionless composability, and secure execution to accelerate open-source AI while improving verifiability and enabling censorship-resistant model access. The platform relies on a heterogeneous AI compute architecture and a proprietary library to power secure AI workflows, including inference, agentic reasoning, and analysis. A web portal and SDK let developers leverage the AI stack without blockchain complexity, helping them build secure, auditable workflows. OpenGradient aims to democratize model ownership and promote transparency in AI by enabling scalable, verifiable computing across open-source models.
Hemi Labs
Seed Round in 2024
Hemi Labs develops a modular blockchain network that integrates Bitcoin and Ethereum, enhancing interoperability, security, and programmability. Co-founded by industry veterans Jeff Garzik and Max Sanchez, the company aims to create a unified 'supernetwork' for seamless asset transfer between these two leading networks.
Gameto is a biotechnology company focused on advancing female reproductive health through innovative therapies. Recognizing the significant lack of treatment options in this underserved area, Gameto employs cutting-edge scientific techniques to develop solutions that enhance the quality of life for women. The company utilizes cellular engineering to create a platform that produces engineered ovarian and endometrial cell lines capable of mimicking the functions of natural cells, including hormone production and response. This platform underpins a portfolio of cellular therapeutics aimed at addressing various female reproductive diseases. Gameto's first initiative, Fertilo, targets improvements in in vitro fertilization (IVF) and egg freezing processes, striving to make them shorter, safer, and more effective. Additionally, the company is developing Deovo, an organoid model of the female reproductive system, and Ameno, a cell-based therapy designed to mitigate health issues related to primary ovarian insufficiency and menopause. Through these efforts, Gameto aims to transform the landscape of female reproductive health care.
Hinkal Protocol
Seed Round in 2024
Hinkal is a self-service dApp and SDK that allows liquid funds, institutions, whales, and consumers to run their strategies privately on their favorite dApps.
Crypto Valley Exchange
Seed Round in 2024
CVEX is a decentralized exchange that provides cryptocurrency holders with futures and options trading, using specific bid-offer dynamics to undercut other trading platforms.
Blueprint Finance
Venture Round in 2024
Blueprint Finance is a technology company that specializes in developing protocols and infrastructure to enhance on-chain finance. It creates decentralized software designed to protect future traders from significant market events, aiming to foster the safety and growth of the global crypto market. The company's platform, an app chain tailored for on-chain debt and credit, provides clients with higher yields, liquidation protection, and advanced predictive capabilities across the decentralized finance (DeFi) ecosystem, initially focusing on money markets.
Architect
Series A in 2024
Architect develops a financial trading platform that facilitates the trade of global futures, options, and digital assets. Its core offering is an institutional-grade infrastructure designed to connect different crypto venues across centralized and decentralized exchanges.
Kinto is the KYC'ed Layer 2 capable of supporting both modern financial institutions and decentralized protocols.
Kinto
Pre Seed Round in 2023
Kinto is the KYC'ed Layer 2 capable of supporting both modern financial institutions and decentralized protocols.
Shuttle Labs
Seed Round in 2023
Lore is developing the network and consumer tooling to onboard the next 1B users.
M^0 Labs
Venture Round in 2023
M^0 is money middleware for the digital age. It is a decentralized, on-chain protocol, as well as a corresponding set of off-chain standards and APIs, that allows holders of high-quality eligible collateral to participate in the issuance of a fungible cryptodollar. With M^0, any number of institutions around the world can tap on turnkey middleware to become their own cryptodollar issuer, upgrading their money tech stack to the digital age.
Architect
Seed Round in 2023
Architect develops a financial trading platform that facilitates the trade of global futures, options, and digital assets. Its core offering is an institutional-grade infrastructure designed to connect different crypto venues across centralized and decentralized exchanges.
Nillion
Seed Round in 2022
Nillion is a computer and network security company that operates a decentralized public network based on a cryptographic primitive called Nil Message Compute (NMC). It develops a decentralized computing platform for secure processing and storage of high-value data, employing privacy technologies to enable confidential computations on masked data. The platform is designed to help healthcare and finance industries manage sensitive information while maintaining robust security standards and operational efficiency.
Prolific Machines
Series A in 2022
Founded in 2020, Prolific Machines is a San Francisco-based biotech company dedicated to revolutionizing cell production for a sustainable future. It combines advanced technologies to enable large-scale cell manufacturing, aiming to improve therapeutic protein production for biotechnology and pharmaceutical companies.
Shuttle Labs
Venture Round in 2022
Lore is developing the network and consumer tooling to onboard the next 1B users.
CellX specializes in developing mushroom-based protein ingredients through morel mycelium fermentation. Their products cater to savory snacks, protein powders, and meat alternatives. Additionally, they license intellectual properties to facilitate the commercialization of cultivated meat.
UPSIDE Foods
Series C in 2022
UPSIDE Foods, formerly known as Memphis Meats, is a cultivated meat company founded in 2015 and headquartered in Berkeley, California. The company specializes in producing real meat, poultry, and seafood directly from animal cells, eliminating the need to raise and slaughter animals. This innovative approach significantly reduces the resource consumption associated with traditional meat production, requiring less water, land, and energy. UPSIDE Foods aims to offer consumers clean, humane, and sustainable meat products, such as beef meatballs, chicken, and duck, all grown in controlled environments. The company is led by Dr. Uma Valeti, who is committed to transforming the food industry with healthier and environmentally friendly alternatives to conventional meat.
Tessera Therapeutics
Series C in 2022
Tessera Therapeutics is an early-stage life sciences company focused on pioneering Gene Writing technology, which allows for the precise insertion of therapeutic messages into the human genome. This innovative approach aims to address diseases at their source by enabling both small and large genetic alterations. By building on recent advancements in gene therapy and gene editing, Tessera Therapeutics seeks to overcome existing limitations in these fields, enhancing their efficacy and reach. Founded by Flagship Pioneering, the company aspires to establish a new category in genetic medicine that can significantly improve patient outcomes and transform healthcare.
Minded is an online psychiatry practice specializing in mental health services for women.
Nucleus
Seed Round in 2021
Nucleus operates a biotechnology research platform focused on next-generation consumer genetic testing and analysis. The company allows users to upload their genetic information obtained from established providers and employs proprietary algorithms to calculate polygenic risk scores and assess disease risk based on genetic variants. Utilizing whole-genome sequencing, Nucleus delivers comprehensive genetic analysis, facilitating advancements in human health and medicine. The results are presented on a user-friendly platform, making complex genetic information accessible and understandable for users.
Cambrian BioPharma
Series C in 2021
Cambrian BioPharma specializes in developing innovative therapeutics aimed at extending healthspan, the period of life spent in good health. As a Distributed Development Company (DisCo), it focuses on advancing scientific breakthroughs targeting biological drivers of aging, initially treating specific diseases and later deploying these interventions preventatively to enhance overall quality of life.
Gameto is a biotechnology company focused on advancing female reproductive health through innovative therapies. Recognizing the significant lack of treatment options in this underserved area, Gameto employs cutting-edge scientific techniques to develop solutions that enhance the quality of life for women. The company utilizes cellular engineering to create a platform that produces engineered ovarian and endometrial cell lines capable of mimicking the functions of natural cells, including hormone production and response. This platform underpins a portfolio of cellular therapeutics aimed at addressing various female reproductive diseases. Gameto's first initiative, Fertilo, targets improvements in in vitro fertilization (IVF) and egg freezing processes, striving to make them shorter, safer, and more effective. Additionally, the company is developing Deovo, an organoid model of the female reproductive system, and Ameno, a cell-based therapy designed to mitigate health issues related to primary ovarian insufficiency and menopause. Through these efforts, Gameto aims to transform the landscape of female reproductive health care.