Trendlines Group

Trendlines Group is an Israel-based venture group that invents, discovers, and incubates innovation-based medical and agrifood technologies. It invests through medical and agrifood incubators in Israel and Singapore and operates Trendlines Labs, its in-house innovation center, to advance early-stage technologies. Founded in 1993 and headquartered in Misgav, it concentrates on medical technology and agrifood technology opportunities.

Todd Dollinger

Co-Founder and Chairman Emeritus

63 past transactions

IBI-Ag

Series A in 2025
IBI-Ag is a biotechnology company developing bioinsecticides using environmentally friendly technology. It focuses on discovering and developing selective, safe, and cost-effective biological solutions to control insects and increase crop production worldwide.

Arcuro Medical

Series A in 2025
Arcuro Medical Ltd. is focused on developing advanced solutions for meniscus repair in the knee. Established in 2013 and based in Misgav, Israel, the company has introduced its proprietary SuperBall repair system, which features a knotless all-suture anchor and a unique delivery mechanism designed for anatomic joint repair. This innovative system allows medical professionals to perform meniscus repairs safely and effectively within the joint space using specialized suture material, addressing the needs of patients with meniscus tears. Through its technology, Arcuro Medical aims to enhance the quality and reliability of meniscus repair procedures.

Celleste Bio

Seed Round in 2024
Celleste Bio is a company that focuses on innovative cell culture techniques to produce high-quality cocoa ingredients. By utilizing naturally occurring cocoa cells, the company eliminates the need for traditional cocoa tree cultivation, offering a sustainable alternative to conventional cocoa production. This approach allows businesses to access environmentally friendly food ingredients without the challenges associated with growing cocoa trees. Celleste Bio's commitment to sustainability and quality positions it as a leader in providing high-value agro products while addressing the environmental impacts of conventional cocoa farming.

AgriG8

Venture Round in 2024
AgriG8 is an agricultural fintech platform focused on closing the financing gap for smallholder farmers. By integrating real-time monitoring with proprietary behavioral analysis, the company provides measurement, reporting, and verification (MRV) capabilities. This technology enables lenders to engage in predictive modeling and active monitoring, thus making investments in climate-resilient farming more attractive. AgriG8's primary objective is to facilitate access to financing for farmers who adopt climate-resilient practices, thereby promoting sustainable agriculture while enhancing financial opportunities for both farmers and lenders.

Peptobiotics

Series A in 2024
Peptobiotics is a biotechnology startup focused on livestock disease prevention through innovative synthetic biology solutions. The company specializes in the development of recombinant custom peptides cultivated from synthetic microorganisms, which serve as antibiotic alternatives for promoting animal health and growth. By providing farmers and breeders with effective tools to protect livestock against pathogens, Peptobiotics aims to enhance agricultural productivity while ensuring humane and sustainable practices. The company’s approach addresses the critical need for disease prevention in livestock without contributing to antibiotic resistance, thereby fostering a more responsible and sustainable agricultural ecosystem.

ViAqua Therapeutics

Venture Round in 2023
Founded in 2014, ViAqua Therapeutics is based in Israel. The company specializes in developing drugs and therapeutics for aquaculture, focusing on the first orally administered treatment to prevent viral diseases.

Insectta

Venture Round in 2023
Insectta is a Singapore-based producer of insect-derived biomaterials and products derived from the black soldier fly. Founded in 2017, the company develops materials and commodities from insects for use across agrifood, pharmaceutical and electronics sectors. Its offerings include pet feeds and farming inputs derived from dried or live black soldier fly larvae, as well as black soldier fly eggs and organic fertilizers. In addition to feed products, Insectta develops biomaterials with high protein content such as chitosan and probiotic components, and pursues applications including organic semiconductors. The company emphasizes a circular economy approach by converting waste into valuable insect-based materials and aims to provide sustainable alternatives to traditional pet feeds and agricultural inputs. Through its integrated portfolio, Insectta seeks to enable farmers and manufacturers to adopt sustainable, insect-derived solutions across multiple industries.

Celleste Bio

Seed Round in 2022
Celleste Bio is a company that focuses on innovative cell culture techniques to produce high-quality cocoa ingredients. By utilizing naturally occurring cocoa cells, the company eliminates the need for traditional cocoa tree cultivation, offering a sustainable alternative to conventional cocoa production. This approach allows businesses to access environmentally friendly food ingredients without the challenges associated with growing cocoa trees. Celleste Bio's commitment to sustainability and quality positions it as a leader in providing high-value agro products while addressing the environmental impacts of conventional cocoa farming.

PlanetWatchers

Series A in 2022
PlanetWatchers is a geospatial analytics company that provides a cloud-based platform to monitor and manage natural assets across multiple sectors, including forestry, energy, government, and agriculture. The software integrates machine learning, elastic cloud infrastructure, and multiple satellite sources to deliver automated monitoring, alerting, and reporting on large-scale assets at regional and global scales. It enables enterprises, governments and NGOs to track asset conditions, assess risks, and improve operational efficiency. In the crop insurance domain, the platform supports policy data capture and claims validation, delivering precise acreage reporting and damage analysis to support underwriting and customer service. Headquartered in San Francisco, PlanetWatchers focuses on turning satellite-derived insights into actionable information for asset management, environmental monitoring, and policy-driven applications.

Phytolon

Series A in 2022
Phytolon Ltd is a company based in Misgav, Israel, specializing in the development of natural food colorants. Founded in 2000, Phytolon utilizes a novel fermentation technology that employs baker's yeast cells as biofactories to produce high-quality, plant-based food colors. This innovative approach offers a healthy alternative to synthetic food dyes, providing food manufacturers with safe, cost-effective, and stable all-natural color solutions. The company's mission is to leverage scientific advancements to promote human health and environmental sustainability in the food industry.

TierraSpec

Venture Round in 2022
TierraSpec is a technology company focused on measuring and validating carbon sequestration in agricultural soils. It has developed a platform that utilizes remote sensing combined with advanced machine learning modeling and unique testing methods. This innovative approach enables farmers to accurately assess the carbon content in their fields, facilitating their participation in carbon credit markets. By providing precise measurements of carbon sequestration, TierraSpec aims to support sustainable agricultural practices and contribute to climate change mitigation efforts.

SetBone Medical

Debt Financing in 2022
SetBone Medical develops a novel bone cement for treating spinal vertebral fractures (VCF), primarily caused by osteoporosis. Its acrylic bone cement is designed to be non-toxic and have a low exothermic reaction, minimizing damage to surrounding tissue.

AgriG8

Funding Round in 2022
AgriG8 is an agricultural fintech platform focused on closing the financing gap for smallholder farmers. By integrating real-time monitoring with proprietary behavioral analysis, the company provides measurement, reporting, and verification (MRV) capabilities. This technology enables lenders to engage in predictive modeling and active monitoring, thus making investments in climate-resilient farming more attractive. AgriG8's primary objective is to facilitate access to financing for farmers who adopt climate-resilient practices, thereby promoting sustainable agriculture while enhancing financial opportunities for both farmers and lenders.

FruitSpec

Series A in 2021
FruitSpec develops hyperspectral imaging and deep learning based technology to estimate fruit yields and manage the fruit value chain. The company designs sensor pods that scan orchards and pairs them with a software platform to count fruits, determine size distribution, and estimate total yield. It offers yield estimation as a service, delivering reports that show the number of fruits and size distribution for a given orchard, with an additional heat-map visualization of fruit quantities. The solutions enable agribusinesses, including farmers, distributors, and insurers, to capture farm data and make planning decisions. Founded in 2016 and based in Tel Aviv, Israel, FruitSpec targets early-season insights to support demand-to-supply management across the fruit industry.

Vensica Medical

Venture Round in 2021
Vensica Medical develops an ultrasound-based drug delivery system for treating urinary bladder cancer. Its device improves drug uptake and penetration into the bladder wall, aiming to enhance treatment efficiency and reduce recurrence rates.

Fidmi Medical

Venture Round in 2021
Founded in Israel in 2014, Fidmi Medical specializes in developing innovative enteral feeding devices. Their products aim to improve nutrition delivery by offering easy insertion, replacement, and removal, enhancing the quality of life for patients who cannot consume food orally.

CoreBone

Venture Round in 2021
CoreBone develops a bioactive, 100% mineral bone graft material for dental, orthopedic, and spine procedures. The graft is created by embedding bioactive minerals into coral skeletons during their growth, producing a strong, porous material with predictable resorption not derived from human or animal bone. It is designed to accelerate healing and improve bone connectivity by offering a natural alternative to conventional grafts and reducing risks associated with human or animal bone. The company holds patents and know-how related to growing coral for medical applications.

AgroScout

Series A in 2021
AgroScout Ltd. is an Israeli company established in 2017 that specializes in developing an artificial intelligence-based platform aimed at enhancing sustainable farming practices. The company's technology provides precision agriculture solutions by utilizing advanced analytics and high-resolution aerial imagery to assess crop health and monitor for pests and diseases. AgroScout's platform supports farmers by offering insights on crop emergence, stand counts, canopy coverage, and biomass throughout the growing season. This continuous monitoring allows for early detection of infestations, enabling more effective curative treatments and reducing pesticide use. By delivering actionable insights into crop management and regional outbreak predictions, AgroScout aims to improve crop yields and profitability while fostering a more sustainable food production supply chain.

Equinom

Series C in 2021
Equinom is a pioneering food-tech company that combines agricultural expertise, culinary knowledge, and advanced technology to develop delicious, nutritious, affordable, and sustainable non-GMO plant-based ingredients. The company uses its proprietary Manna™ platform, powered by AI, to naturally breed superior crops optimized for human consumption. Equinom partners with leading companies in the industry to supply unrivaled ingredients, contributing to the global surge in plant-based eating.

IBI-Ag

Seed Round in 2021
IBI-Ag is a biotechnology company developing bioinsecticides using environmentally friendly technology. It focuses on discovering and developing selective, safe, and cost-effective biological solutions to control insects and increase crop production worldwide.

ViAqua Therapeutics

Venture Round in 2021
Founded in 2014, ViAqua Therapeutics is based in Israel. The company specializes in developing drugs and therapeutics for aquaculture, focusing on the first orally administered treatment to prevent viral diseases.

PlanetWatchers

Seed Round in 2021
PlanetWatchers is a geospatial analytics company that provides a cloud-based platform to monitor and manage natural assets across multiple sectors, including forestry, energy, government, and agriculture. The software integrates machine learning, elastic cloud infrastructure, and multiple satellite sources to deliver automated monitoring, alerting, and reporting on large-scale assets at regional and global scales. It enables enterprises, governments and NGOs to track asset conditions, assess risks, and improve operational efficiency. In the crop insurance domain, the platform supports policy data capture and claims validation, delivering precise acreage reporting and damage analysis to support underwriting and customer service. Headquartered in San Francisco, PlanetWatchers focuses on turning satellite-derived insights into actionable information for asset management, environmental monitoring, and policy-driven applications.

ZygoFix

Seed Round in 2021
ZygoFix is a medical device company specializing in spine technology. It has developed an innovative three-dimensional-printed implant designed to lock the facet joint of the lumbar spine. This device leverages the anatomy of the spine to provide stability, eliminating the need for traditional external screw-based bridges and reducing the reliance on pedicle screws. By doing so, ZygoFix aims to minimize the risks associated with improper screw placement, thereby enhancing safety in spinal surgeries. The company's focus on advancing spinal stability reflects its commitment to improving patient outcomes in the medical field.

Limaca Medical

Seed Round in 2020
Limaca Medical is focused on advancing the field of precision medicine through the development of an innovative ultrasound-guided biopsy system. This cutting-edge device enhances the diagnostic process for tumors in the gastrointestinal system by providing reliable, high-quality core tissue samples. Traditional methods often deliver subpar tissue samples, hindering accurate diagnosis and clinical outcomes. Limaca Medical's electro-mechanically driven endoscopic device addresses these shortcomings, enabling medical practitioners to obtain superior tissue specimens for histopathologic analysis, thereby improving diagnostic accuracy and patient care.

Phytolon

Funding Round in 2020
Phytolon Ltd is a company based in Misgav, Israel, specializing in the development of natural food colorants. Founded in 2000, Phytolon utilizes a novel fermentation technology that employs baker's yeast cells as biofactories to produce high-quality, plant-based food colors. This innovative approach offers a healthy alternative to synthetic food dyes, providing food manufacturers with safe, cost-effective, and stable all-natural color solutions. The company's mission is to leverage scientific advancements to promote human health and environmental sustainability in the food industry.

Vessi Medical

Venture Round in 2020
Vessi Medical is an Israeli medical device startup focused on innovating treatment for Non-Muscle-Invasive Bladder Cancer (NMIBC) through a novel surface cryotherapy approach. This technique employs extreme cold to freeze and eliminate abnormal tissue, providing a minimally invasive alternative to the standard TransUrethral Resection of Bladder Tumor (TURBT), which is often inadequate and requires invasive surgery under general anesthesia. Vessi's technology, comprising a standalone console and a disposable catheter, allows for targeted cell destruction while safeguarding healthy bladder tissue. This office-based procedure not only reduces the need for costly hospital stays and repeat surgeries but also addresses the high recurrence rate of NMIBC, which affects millions globally. With promising proof of concept already demonstrated in animal studies, Vessi aims to capture the $1.2 billion NMIBC market, while also exploring future applications for treating overactive bladder and urinary tract infections. The company is supported by experienced professionals in the medical device and cryotherapy sectors, ensuring a strong foundation for its innovations.

Saturas

Series B in 2020
Saturas is a precision agriculture company that develops and manufactures stem water potential SWP sensor systems for irrigation management. Its miniature sensors are embedded in the trunks of trees, vines, and other crops, providing direct contact with water tissues to deliver accurate, real-time measurements of plant water status. The system comprises implanted sensors, in-orchard wireless transponders, and a control unit that transmits data to a central system connected to irrigation controllers. This enables automated, real-time irrigation tailoring to crop needs, reducing water usage while aiming to increase fruit production, size, and sugar content. Saturas' technology supports vineyards and other crops by delivering easy-to-read reports to farmers and enabling precise irrigation decisions. The company was founded in 2013 and is based in Misgav, Israel.

Insectta

Seed Round in 2020
Insectta is a Singapore-based producer of insect-derived biomaterials and products derived from the black soldier fly. Founded in 2017, the company develops materials and commodities from insects for use across agrifood, pharmaceutical and electronics sectors. Its offerings include pet feeds and farming inputs derived from dried or live black soldier fly larvae, as well as black soldier fly eggs and organic fertilizers. In addition to feed products, Insectta develops biomaterials with high protein content such as chitosan and probiotic components, and pursues applications including organic semiconductors. The company emphasizes a circular economy approach by converting waste into valuable insect-based materials and aims to provide sustainable alternatives to traditional pet feeds and agricultural inputs. Through its integrated portfolio, Insectta seeks to enable farmers and manufacturers to adopt sustainable, insect-derived solutions across multiple industries.

AgroScout

Seed Round in 2020
AgroScout Ltd. is an Israeli company established in 2017 that specializes in developing an artificial intelligence-based platform aimed at enhancing sustainable farming practices. The company's technology provides precision agriculture solutions by utilizing advanced analytics and high-resolution aerial imagery to assess crop health and monitor for pests and diseases. AgroScout's platform supports farmers by offering insights on crop emergence, stand counts, canopy coverage, and biomass throughout the growing season. This continuous monitoring allows for early detection of infestations, enabling more effective curative treatments and reducing pesticide use. By delivering actionable insights into crop management and regional outbreak predictions, AgroScout aims to improve crop yields and profitability while fostering a more sustainable food production supply chain.

OrthoSpin

Series B in 2020
OrthoSpin Limited is a medical technology company based in Misgav, Israel, founded in 2014. It specializes in the development of innovative robotic external fixation systems designed to enhance patient treatment for bone injuries and limb deformities. The company's dynamic external fixators aim to address the challenges associated with traditional systems, which can be cumbersome and painful while requiring significant maintenance. OrthoSpin's proprietary technology incorporates a lightweight motor and a control box that facilitate automatic, continuous adjustments to the fixation frame without patient involvement. This smart system not only helps ensure that prescribed treatment protocols are followed but also allows physicians to monitor patient progress in real-time and make necessary adjustments to treatment plans. The company's focus on improving clinical outcomes and reducing complications positions it as a significant player in the orthopedic field.

AlgaHealth

Seed Round in 2020
AlgaHealth is focused on the development of innovative microalgal sources for the production of high-quality fucoxanthin, a compound with applications in health and cosmetics. The company has created a novel microalgae cultivation algorithm that enhances efficiency by 15% to 50%, alongside processing protocols designed to significantly reduce production costs to about 20% of current levels. In addition to fucoxanthin, AlgaHealth aims to produce polysaccharides as a by-product, thereby offering a secondary source of valuable microalgal products. The company's advanced methods for cultivating microalgae inland and its unique strains will allow for the commercial production of premium-quality fucoxanthin, catering to the growing market demand for quality additives in health supplements and skincare products. This positions AlgaHealth as a key player in sustainable biotechnology practices and the advancement of effective health solutions.

Equinom

Series B in 2020
Equinom is a pioneering food-tech company that combines agricultural expertise, culinary knowledge, and advanced technology to develop delicious, nutritious, affordable, and sustainable non-GMO plant-based ingredients. The company uses its proprietary Manna™ platform, powered by AI, to naturally breed superior crops optimized for human consumption. Equinom partners with leading companies in the industry to supply unrivaled ingredients, contributing to the global surge in plant-based eating.

AquiNovo

Seed Round in 2020
AquiNovo is a company focused on developing innovative feed additives aimed at enhancing fish growth in the aquaculture industry. As the demand for fish protein rises and marine resources become increasingly depleted, AquiNovo addresses the need for sustainable solutions that optimize fish yields while utilizing existing resources and infrastructures. The company’s platform specializes in the creation of non-genetically modified and non-hormonal peptides that significantly improve gut performance and overall health in fish. This advancement not only boosts production yields for farmers but also offers potential treatments for gastrointestinal conditions in both production and companion animals, thereby contributing to the sustainability and efficiency of aquaculture practices.

ProJini Agchem

Seed Round in 2020
ProJini Agchem is developing a solution focused on new type of molecular targets: protein-protein interactions. While such interactions are at the core of any organism, it is very challenging to develop inhibitors for such systems via conventional approaches due to their spatial and chemical characteristics. The platform, developed by scientists Maayan Gal, PhD and Itay Bloch at the Migal Galilee Research Institute Ltd., leverages a combination of computational-biophysical methods to tackle this significant challenge. ProJini Agchem received an exclusive license to use this platform to develop novel pesticides with new modes of action.

BioFishency

Venture Round in 2019
BioFishency develops integrated water treatment solutions for land‑based aquaculture. Its plug‑and‑play system operates across extensive ponds, constructed ponds, and recirculating systems, allowing farms to double or triple production while retaining existing infrastructure. The technology addresses limited water availability and toxic ammonia buildup, improving water quality to enhance fish survival, growth, and reproduction. A cloud‑controlled, temperature‑agnostic platform delivers immediate operation, reduces water and energy use, eliminates off‑flavors, and lowers the carbon footprint, thereby boosting yields and operational efficiency.

Agency for Science, Technology and Research

Venture Round in 2018
The Agency for Science, Technology and Research (A*STAR) is a Singaporean government agency established in 1991, dedicated to promoting scientific research and technological innovation. It oversees 18 research entities focused on biomedical sciences and physical sciences and engineering, primarily located in Biopolis and Fusionopolis. A*STAR plays a crucial role in advancing Singapore's economic sectors by providing essential intellectual, human, and industrial resources to industry partners. Additionally, the agency supports extramural research collaborations with universities, hospitals, and research centers, both locally and internationally, while nurturing talent and leadership within the research community.

Saturas

Series A in 2018
Saturas is a precision agriculture company that develops and manufactures stem water potential SWP sensor systems for irrigation management. Its miniature sensors are embedded in the trunks of trees, vines, and other crops, providing direct contact with water tissues to deliver accurate, real-time measurements of plant water status. The system comprises implanted sensors, in-orchard wireless transponders, and a control unit that transmits data to a central system connected to irrigation controllers. This enables automated, real-time irrigation tailoring to crop needs, reducing water usage while aiming to increase fruit production, size, and sugar content. Saturas' technology supports vineyards and other crops by delivering easy-to-read reports to farmers and enabling precise irrigation decisions. The company was founded in 2013 and is based in Misgav, Israel.

AlgaHealth

Seed Round in 2017
AlgaHealth is focused on the development of innovative microalgal sources for the production of high-quality fucoxanthin, a compound with applications in health and cosmetics. The company has created a novel microalgae cultivation algorithm that enhances efficiency by 15% to 50%, alongside processing protocols designed to significantly reduce production costs to about 20% of current levels. In addition to fucoxanthin, AlgaHealth aims to produce polysaccharides as a by-product, thereby offering a secondary source of valuable microalgal products. The company's advanced methods for cultivating microalgae inland and its unique strains will allow for the commercial production of premium-quality fucoxanthin, catering to the growing market demand for quality additives in health supplements and skincare products. This positions AlgaHealth as a key player in sustainable biotechnology practices and the advancement of effective health solutions.

ElastiMed

Venture Round in 2017
ElastiMed develops innovative medical devices, initially focusing on smart compression therapy. Its flagship product is a wearable device using proprietary smart materials to improve leg circulation, treating Chronic Venous Insufficiency and preventing Deep Venous Thrombosis.

FruitSpec

Seed Round in 2017
FruitSpec develops hyperspectral imaging and deep learning based technology to estimate fruit yields and manage the fruit value chain. The company designs sensor pods that scan orchards and pairs them with a software platform to count fruits, determine size distribution, and estimate total yield. It offers yield estimation as a service, delivering reports that show the number of fruits and size distribution for a given orchard, with an additional heat-map visualization of fruit quantities. The solutions enable agribusinesses, including farmers, distributors, and insurers, to capture farm data and make planning decisions. Founded in 2016 and based in Tel Aviv, Israel, FruitSpec targets early-season insights to support demand-to-supply management across the fruit industry.

Gordian Surgical

Series A in 2016
Founded in 2012, Gordian Surgical develops innovative laparoscopy equipment. Its flagship product, TroClose 1200, is an integrated port closure solution used to open and suture close the abdominal wall during laparoscopic procedures.

Eden Shield

Convertible Note in 2016
EdenShield Ltd. is an Israel-based AgTech company founded in 2012, specializing in the development of nontoxic insect control products for greenhouse crops. The company offers a range of organic and chemical-free solutions, including EdenNet, EdenDirect, and EdenForte, which are formulated from botanical extracts and nutrients derived from native Israeli semi-desert plants. These products utilize proprietary aromatic ingredients that mask plant odors and reduce insect attraction, effectively preventing pest-related damage and the spread of viruses. EdenShield's innovative approach helps growers enhance the yield and health of crops, including cannabis, vegetables, and flowers, while promoting environmentally friendly agricultural practices.

MetoMotion

Seed Round in 2016
MetoMotion is a company focused on creating a multipurpose robotic system, known as GRoW, aimed at addressing labor-intensive tasks in greenhouse vegetable production, particularly for greenhouse tomatoes. The company's robotic platform leverages artificial intelligence to identify and locate ripe fruit, facilitating seamless integration with existing farming systems. This innovation allows growers to enhance their greenhouse operations by providing valuable insights that can lead to increased yield and quality while minimizing waste. By reducing reliance on human labor, MetoMotion seeks to lower operational costs and improve efficiency in the agricultural sector.

Hargol™ FoodTech

Seed Round in 2016
Hargol™ FoodTech is the world's first commercial grasshopper farm! Grasshoppers are nature's most efficient protein source. Hargol™ FoodTech revolutionize the protein ingredient industry by providing a healthier and more sustainable and affordable alternative, becoming the leading intensive rearing company of grasshoppers in the world. The company is at the forefront of high quality nutrients and healthy grasshoppers supply to markets around the world, improving current market wild-harvested supply by providing year-round availability, nutrients content & quality and costs reduction. For its first line of products, Hargol FoodTech relies on methods and technologies of intensive breeding and growing of three grasshopper species that are processed into protein powders. The company is offering grasshopper based protein ingredient in North America markets to food/ingredient manufacturers and whole grasshoppers. Hargol™ FoodTech have thus far been attracting the interest of food producers, distributors and retailers in the North America, Europe and other regions of the world with whole grasshoppers, grasshopper’s nutrient-rich powder and innovative food products. With the expected 70% rise in demand for animal source protein over the next decades and with existing animal source protein taking a big toll on the environment there is a need for an alternative – Both sustainable and affordable for populations around the globe. Enhanced by their vegetarian diet grasshoppers’ nutrient content is superior compare to other insects or animal source protein: Over 70% whole protein, Omega-3 & Omega-6, Zinc, Iron, & Folic acid. Grasshoppers are also the only Kosher and Halal insect in the world!

Saturas

Seed Round in 2016
Saturas is a precision agriculture company that develops and manufactures stem water potential SWP sensor systems for irrigation management. Its miniature sensors are embedded in the trunks of trees, vines, and other crops, providing direct contact with water tissues to deliver accurate, real-time measurements of plant water status. The system comprises implanted sensors, in-orchard wireless transponders, and a control unit that transmits data to a central system connected to irrigation controllers. This enables automated, real-time irrigation tailoring to crop needs, reducing water usage while aiming to increase fruit production, size, and sugar content. Saturas' technology supports vineyards and other crops by delivering easy-to-read reports to farmers and enabling precise irrigation decisions. The company was founded in 2013 and is based in Misgav, Israel.

Eden Shield

Seed Round in 2016
EdenShield Ltd. is an Israel-based AgTech company founded in 2012, specializing in the development of nontoxic insect control products for greenhouse crops. The company offers a range of organic and chemical-free solutions, including EdenNet, EdenDirect, and EdenForte, which are formulated from botanical extracts and nutrients derived from native Israeli semi-desert plants. These products utilize proprietary aromatic ingredients that mask plant odors and reduce insect attraction, effectively preventing pest-related damage and the spread of viruses. EdenShield's innovative approach helps growers enhance the yield and health of crops, including cannabis, vegetables, and flowers, while promoting environmentally friendly agricultural practices.

Catalyst AgTech

Seed Round in 2014
Catalyst AgTech Ltd. is an Israeli company focused on developing innovative technology for the agriculture sector, specifically aimed at minimizing the environmental impact of agrochemical products. The company has created a customizable technology with a self-destruction mechanism designed for use in persistent pesticides, herbicides, and fungicides. This patented catalyst technology effectively breaks down specific chemicals in fertilizers, significantly reducing their harmful effects after application and preventing groundwater contamination. By addressing the growing demand for essential pesticides while mitigating adverse environmental consequences, Catalyst AgTech offers a solution that promotes sustainable agricultural practices. The company is supported by an experienced management team and benefits from scientific collaboration with the Weizmann Institute of Science.

Valentis Nanotech

Seed Round in 2014
Valentis Nanotech, established in 2013, specializes in the production of innovative polymeric films, coatings, and compounds utilizing cellulose nanocrystals (CNC) combined with nanoparticles. The company's patented technology enables the creation of biodegradable and transparent materials derived from plant pulp waste, resulting in films that are thin, strong, and environmentally friendly. These films offer enhanced properties, such as improved strength, better spectral control, and effective barriers against UV rays, oxygen, and moisture. Valentis has engaged in collaborations with a prominent agricultural thermoplastics company in Israel since July 2014, focusing on new product development to meet specific industry needs.

LapSpace Medical

Seed Round in 2013
LapSpace Medical Ltd. is a company based in Misgav, Israel, that specializes in the development of innovative devices for laparoscopic surgery. Founded in 2011, the company focuses on creating an inflatable balloon retractor designed to enhance surgical procedures. This retractor effectively and gently retracts abdominal organs, such as the intestines, thereby minimizing complications and shortening operating times. Additionally, it reduces the need for extra assistance during surgery, ultimately leading to lower costs and facilitating quicker patient recovery with minimal incisions. The LapSpace team combines extensive business expertise with medical knowledge, positioning the company as a key player in advancing laparoscopic techniques.

ApiFix

Series B in 2013
ApiFix develops a minimally invasive scoliosis deformity correction system for treating Adolescent Idiopathic Scoliosis (AIS). Its unique ratchet mechanism enables incremental corrections over several months, reducing the need for aggressive surgery.

MitrAssist

Angel Round in 2013
MitrAssist is a medical device company focused on addressing mitral valve regurgitation (MR) through an innovative and minimally invasive approach. The company has developed a proprietary mitral valve implant that complements the natural mitral valve rather than replacing or repairing it. This unique "valve-in-valve" technique enhances the functionality of the existing valve, providing an effective treatment option for patients suffering from MR. MitrAssist's implant is designed to address the challenges associated with MR, offering a solution that surpasses current minimally invasive alternatives. By prioritizing patient health and comfort, MitrAssist aims to significantly improve treatment outcomes for individuals with this condition.

Immunovative Therapies

Venture Round in 2012
Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy products to treat cancer and infectious diseases in adult patients. Established in 2004, the company specializes in using living immune cells as active ingredients in its therapies. Key products include AlloStim, which utilizes activated T-Stim cells for infusion; CryoVax, an in-situ therapeutic cancer vaccine targeting disseminated metastatic tumors; CRCL, a source of patient-specific tumor antigens; and AlloVax, an individualized anti-cancer vaccine designed to educate the immune system during cancer remission to prevent recurrence. Immunovative Therapies develops treatment protocols for various conditions, including hematological malignancies, prostate cancer, breast cancer, glioblastoma multiforme, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. The company's mission is to enhance patient quality of life and provide effective treatment options through its novel immunotherapeutic approaches.

InnoLap Surgical

Venture Round in 2012
InnoLap Surgical develops a device for scarless laparoscopic procedures. The device comprises a handle, thin 3 mm needle, and 5-10 mm detachable and replaceable operating heads. The company was founded in 2012 and is based in Misgav, Israel. As of September 30, 2013, InnoLap Surgical Ltd. operates as a subsidiary of Teleflex Incorporated.

Polytouch Medical

Seed Round in 2010
Polytouch Medical is dedicated to advancing minimally invasive surgery through the development of innovative solutions for laparoscopic procedures, particularly in hernia repair. The company specializes in hernia mesh placement technologies, with its flagship product, PatchAssist, designed to facilitate the treatment of ventral hernias. By collaborating closely with physicians, Polytouch Medical focuses on enhancing mesh deployment and placement techniques, thereby enabling quicker treatment initiation and increasing the likelihood of successful outcomes for patients. The company prides itself on its dedicated workforce, medical advisors who translate ideas into practical applications, and board members who assist in bringing these products to market.

Nephera

Series B in 2010
Nephera Ltd., established in 2008 and headquartered in Misgav, Israel, specializes in developing medical devices for treating kidney dysfunction associated with chronic health conditions. The company's flagship product is an implantable pulse generator designed to enhance and maintain kidney functionality in patients suffering from congestive heart failure (CHF). This device operates by modulating sympathetic nerve activity through electrical stimulation of the urinary tract, thereby preserving renal function and improving diuretic therapy outcomes during frequent hospitalizations.

Inspiro Medical

Venture Round in 2010
Inspiro Medical Ltd. is a medical device company focused on creating an innovative inhalation platform that facilitates the delivery of both small molecules, including corticosteroids and beta agonists, and larger macromolecules, such as antibodies and vaccines. The company is actively conducting clinical trials involving its proprietary dry powder inhaler, Inspiromatic, specifically targeting children with asthma. Through its advanced technology, Inspiro Medical aims to enhance treatment options for respiratory diseases.

Stimatix GI

Venture Round in 2009
Stimatix GI is an early-stage startup founded in June 2009, operating under the Misgav Venture Accelerator with funding from the Office of the Chief Scientist. The company specializes in the development of innovative ostomy appliances, particularly its Artificial Ostomy Sphincter (AOS) product line, which includes the AOS-1000 and AOS-C2000. These unique colostomy devices enable voluntary bowel evacuation, providing users with greater control over their routines. Designed to be aesthetically pleasing and user-friendly, the AOS products effectively seal the stoma, addressing the common challenges associated with traditional adhesive bags. By offering a low-profile solution, Stimatix GI enhances the quality of life for individuals with stomas, restoring functions similar to those of a healthy anus and rectum while minimizing skin irritation and discomfort often associated with ostomy care.

ETView Medical

Venture Round in 2009
ETView Medical Ltd. specializes in advanced airway management solutions by integrating continuous direct airway visualization with its medical products. The company has developed patented single-use single and double-lumen endotracheal tubes, which are equipped with a high-resolution video imaging system. These innovative tubes, such as the VivaSight SL and DL, feature a miniature camera and light source that assist medical professionals during difficult intubations. ETView Medical aims to enhance the safety and efficacy of airway management through its cutting-edge imaging technologies and related medical accessories.

FLOWSENSE

Venture Round in 2009
The URINFO 2000 fluid monitoring system is the only feasible solution for the accurate, real-time, and continuous monitoring of urine output. The product is based on FlowSense’s patented optical flow sensing technology. URINFO2000 has been used in the critical care setting to optimize fluid and electrolyte balance, treat acute kidney injury, and prevent renal failure.

VivoText

Seed Round in 2008
VivoText is a creative digital speech platform that specializes in expressive speech synthesis for the entertainment and media sectors. The company develops a text-to-speech engine that allows content creators to craft personalized and scalable audio content using virtual human voices. VivoText's technology enables users to maintain creative control over the emotional expression and nuances of the speech output, making it particularly valuable for industries such as publishing, gaming, and marketing. By providing advanced tools for narration, voiceover, and complex spoken content, VivoText empowers voice artists to create lifelike digital speech that meets individual preferences and enhances engagement with audiences.

LifeBond

Seed Round in 2007
LifeBond Ltd. is a developer and manufacturer of absorbable bio-surgical medical devices focused on tissue repair, aiming to enhance patient recovery and support the body's natural healing process. Founded in 2006 and based in Caesarea, Israel, the company offers a range of products, including the LifeSeal Surgical Sealant, which provides reinforcement to minimize post-operative complications such as staple-line leakage in various surgical procedures. Another key product, LifeMesh Self-Fixating Mesh, is designed for secure fixation during hernia repair, addressing post-surgical complications effectively. In addition to these products, LifeBond is engaged in the development of tissue adhesives and absorbable hemostats. Their innovative devices are designed to meet a variety of surgical needs and are available in markets including China, the United States, and Europe, although many products remain investigational and have not yet received market approval.

BioSight

Venture Round in 2007
BioSight Ltd., established in 1999 and headquartered in Lod, Israel, is a biopharmaceutical company specializing in the development of innovative cancer-targeted pro-drugs. It focuses on creating non-toxic conjugates like its cytarabine-asparagine conjugate for treating acute myeloid leukemia patients worldwide. BioSight's proprietary technology, S2DOT™, enables targeted drug release inside cancer cells, minimizing systemic toxicity compared to conventional chemotherapy treatments.

Immunovative Therapies

Seed Round in 2004
Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy products to treat cancer and infectious diseases in adult patients. Established in 2004, the company specializes in using living immune cells as active ingredients in its therapies. Key products include AlloStim, which utilizes activated T-Stim cells for infusion; CryoVax, an in-situ therapeutic cancer vaccine targeting disseminated metastatic tumors; CRCL, a source of patient-specific tumor antigens; and AlloVax, an individualized anti-cancer vaccine designed to educate the immune system during cancer remission to prevent recurrence. Immunovative Therapies develops treatment protocols for various conditions, including hematological malignancies, prostate cancer, breast cancer, glioblastoma multiforme, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. The company's mission is to enhance patient quality of life and provide effective treatment options through its novel immunotherapeutic approaches.
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