Trendlines

IBI-Ag is a biotechnology company dedicated to developing innovative bioinsecticides that provide environmentally friendly pest management solutions for farmers. The company focuses on creating natural single-domain antibody insecticides designed to enhance crop production while ensuring the safety of farm workers, consumers, and the environment. By utilizing advanced technology and fermentation processes, IBI-Ag offers efficient and selective pest control solutions that lower agricultural costs. The company's platform is built on thorough testing and extensive learning, allowing farmers to access customized biological pest control strategies that meet their specific needs. Through its commitment to sustainable practices, IBI-Ag aims to revolutionize the agricultural landscape by promoting safer and more effective methods of insect management.

Arcuro Medical Ltd. is a company based in Misgav, Israel, specializing in the development of a meniscus repair system designed for the anatomical repair of knee joints. Founded in 2013, the company has created the SuperBall repair system, which features a knotless, all-suture anchor and an innovative delivery mechanism. This proprietary system allows medical practitioners to perform safe and effective repairs of meniscus tears within the joint space using suture material. Arcuro Medical aims to enhance the treatment options available for knee injuries, focusing on reliability and efficacy in surgical procedures.

Celleste Bio is a company focused on producing high-quality cocoa ingredients through advanced cell culture techniques. By utilizing naturally occurring cocoa cells, Celleste eliminates the need for traditional cocoa tree cultivation, offering a sustainable alternative for businesses seeking environmentally friendly food ingredients. The company's methods avoid genetic modification and manipulation, ensuring that their products meet high standards of quality and sustainability. This innovative approach not only addresses the challenges of cocoa farming but also provides a reliable source of valuable cocoa components for various applications in the food industry.

AgriG8 is an agricultural fintech platform focused on closing the financing gap for smallholder farmers. By integrating real-time monitoring with proprietary behavioral analysis, the company provides measurement, reporting, and verification (MRV) capabilities. This technology enables lenders to engage in predictive modeling and active monitoring, thus making investments in climate-resilient farming more attractive. AgriG8's primary objective is to facilitate access to financing for farmers who adopt climate-resilient practices, thereby promoting sustainable agriculture while enhancing financial opportunities for both farmers and lenders.

Peptobiotics is a biotechnology startup focused on enhancing livestock health and productivity through innovative disease prevention solutions. The company specializes in developing recombinant custom peptides using synthetic biology microorganisms as alternatives to traditional antibiotics. By providing farmers with effective tools to promote growth and protect animals from pathogens, Peptobiotics aims to foster a more humane and sustainable agricultural system. Its approach not only addresses the pressing issue of antibiotic resistance but also supports farmers in maintaining healthy livestock, leading to improved agricultural outcomes without the use of conventional antibiotics.

ViAqua Therapeutics Ltd is an Israeli company founded in 2014 that specializes in developing innovative drugs and therapeutics for the aquaculture industry. The company focuses on creating the first orally administered treatment designed to combat viral diseases affecting aquatic species, particularly shrimp. ViAqua's proprietary platform employs a unique RNAi nanoparticle formulation that triggers a cellular response to disable viral infections. This technology enables the delivery of coated nanoparticles through feed or immersion techniques, enhancing the resistance of aquaculture species against viral epidemics. With a management team experienced in business development and industrial biotechnology, ViAqua aims to improve the health and sustainability of aquaculture practices.

Insectta, founded in 2017, specializes in producing biomaterials derived from insects, targeting applications in various industries, including agrifood, pharmaceuticals, and electronics. The company aims to foster a circular economy in the insect farming sector by offering high-protein alternatives to traditional pet feeds and developing fertilizers for agricultural use. This innovative approach allows farmers to transform waste into valuable biomaterials, promoting sustainability and enhancing resource efficiency in farming practices.

Celleste Bio is a company focused on producing high-quality cocoa ingredients through advanced cell culture techniques. By utilizing naturally occurring cocoa cells, Celleste eliminates the need for traditional cocoa tree cultivation, offering a sustainable alternative for businesses seeking environmentally friendly food ingredients. The company's methods avoid genetic modification and manipulation, ensuring that their products meet high standards of quality and sustainability. This innovative approach not only addresses the challenges of cocoa farming but also provides a reliable source of valuable cocoa components for various applications in the food industry.

PlanetWatchers, Inc. is a company based in San Francisco, California, that specializes in a platform for geospatial analytics focused on natural asset monitoring. Founded in 2016, PlanetWatchers provides a software-as-a-service solution designed for enterprises, governments, and NGOs across various sectors, including forestry, oil and gas. The company leverages advanced machine learning algorithms and synthetic aperture radar (SAR) technology to transform extensive manual data collection into rapid automated analysis. This capability enables organizations to efficiently monitor their natural assets, delivering critical insights that support the management of large-scale resources and enhance decision-making processes. By utilizing multi-source satellite sensors and elastic cloud infrastructure, PlanetWatchers facilitates effective monitoring and alerting systems that are essential for sectors such as crop insurance, improving accuracy and efficiency in claims validation.

Phytolon Ltd, founded in 2000 and based in Misgav, Israel, specializes in the development of natural food colorants. The company has established a novel and sustainable technology that utilizes fermentation processes with baker’s yeast cells as biofactories to produce high-quality, plant-based food colors. This innovative approach provides a healthy alternative to synthetic food dyes, offering food manufacturers safe, cost-effective, and stable all-natural colors. Phytolon is dedicated to promoting human health and environmental sustainability through scientific advancement in the food color industry.

TierraSpec is a company that has developed a platform designed to measure and validate carbon sequestration in agricultural soils. Utilizing remote sensing technology, the platform incorporates unique testing methods and advanced machine learning modeling to accurately assess the carbon content in fields. This capability allows farmers to effectively report on their soil's carbon sequestration, facilitating their access to carbon credit markets. By providing these tools, TierraSpec supports sustainable farming practices and contributes to climate change mitigation efforts.

SetBone Medical focuses on developing an innovative bone cement specifically for treating vertebral compression fractures (VCF), often resulting from osteoporosis. The company's technology features an acrylic bone cement that avoids toxic monomers, ensuring safety for patients. Additionally, it has a low exothermic reaction, which helps maintain a lower curing temperature, thus protecting surrounding tissues from damage during procedures. This advancement allows orthopedic surgeons to effectively and safely address spinal fractures and other orthopedic conditions.

AgriG8 is an agricultural fintech platform focused on closing the financing gap for smallholder farmers. By integrating real-time monitoring with proprietary behavioral analysis, the company provides measurement, reporting, and verification (MRV) capabilities. This technology enables lenders to engage in predictive modeling and active monitoring, thus making investments in climate-resilient farming more attractive. AgriG8's primary objective is to facilitate access to financing for farmers who adopt climate-resilient practices, thereby promoting sustainable agriculture while enhancing financial opportunities for both farmers and lenders.

FruitSpec Ltd. specializes in designing and manufacturing hyperspectral sensor systems for fruit yield estimation, catering to farmers, distributors, and insurance companies. Founded in 2016 and based in Tel Aviv, Israel, the company offers FruitSpec sensor pods that scan orchards to analyze fruit trees. This technology employs hyperspectral imaging and deep learning algorithms to differentiate between leaves and fruits, generating valuable insights for agribusinesses. FruitSpec provides a comprehensive yield estimation service, which includes scanning the orchard and delivering detailed reports. These reports feature the number of fruits and their size distribution, as well as heat maps indicating fruit quantity distribution within the orchard. By facilitating data collection and yield prediction, FruitSpec enables stakeholders in the fruit value chain to optimize their demand-to-supply processes and make informed business decisions.

Vensica is focused on developing an innovative ultrasound-based drug delivery system aimed at improving the treatment of urinary bladder conditions, particularly bladder cancer and overactive bladder (OAB). Traditional treatment methods involve instilling medication directly into the bladder via a catheter, which can be inefficient and painful. Vensica's approach utilizes ultrasound to enhance drug uptake and penetration into the bladder wall, facilitating a quick and pain-free procedure for patients. This method aims to increase the effectiveness of treatments and reduce the high recurrence rates associated with bladder cancer, which can be as high as 70%. By leveraging ultrasound technology, Vensica seeks to provide safer and more effective treatment options for individuals suffering from these conditions.

Fidmi Medical is an Israeli start-up established in 2014, focused on creating innovative feeding devices aimed at improving nutrition delivery and enhancing the quality of life for patients who cannot consume food orally. The company’s devices are designed to eliminate the drawbacks of existing feeding solutions, providing a secure, reliable, and discreet method for delivering food, liquids, and medications directly into the stomach. With a focus on user-friendly design, Fidmi Medical ensures that its devices allow for easy insertion, replacement, and removal, thereby facilitating better access and management for patients and caregivers alike.

CoreBone specializes in the development of a bioactive bone graft material that is suitable for dental, orthopedic, and spinal applications. The company has created a 100% mineral-based graft that incorporates bioactive minerals, such as silicium, into the skeleton of corals during their natural growth process. This innovative approach enhances healing and improves bone connectivity, offering a robust alternative to traditional bone grafts derived from human or animal sources. By providing a material that possesses essential bone-like qualities—such as strength, porosity, and bioactivity—CoreBone aims to promote natural alternatives while raising awareness about the biological risks associated with conventional graft materials. Founded by CEO Ohad Schwartz and CTO Prof. Itzhak Binederman, CoreBone holds patents and extensive expertise in cultivating coral for medical applications.

AgroScout Ltd. is an Israeli company established in 2017 that specializes in developing an artificial intelligence-based platform aimed at enhancing sustainable farming practices. The company's technology provides precision agriculture solutions by utilizing advanced analytics and high-resolution aerial imagery to assess crop health and monitor for pests and diseases. AgroScout's platform supports farmers by offering insights on crop emergence, stand counts, canopy coverage, and biomass throughout the growing season. This continuous monitoring allows for early detection of infestations, enabling more effective curative treatments and reducing pesticide use. By delivering actionable insights into crop management and regional outbreak predictions, AgroScout aims to improve crop yields and profitability while fostering a more sustainable food production supply chain.

Equinom is a food-tech company focused on developing sustainable, non-GMO plant-based ingredients through innovative agricultural practices and advanced technology. It addresses the challenge of inadequate crop production for human consumption, as many crops are traditionally grown for animal feed, requiring costly processing to make them suitable for food. By leveraging its proprietary Manna™ technology platform, Equinom employs artificial intelligence to accelerate the development of high-yield, naturally bred crops that enhance the taste, nutrition, and affordability of meat and dairy alternatives. This approach not only ensures quality and consumer satisfaction but also promotes biodiversity and climate resilience, critical for future food security in the face of climate change. Collaborating with various partners, Equinom has gained recognition as a reliable supplier of premium ingredients, supported by notable investors that bolster its position in the rapidly growing plant-based food market.

IBI-Ag is a biotechnology company dedicated to developing innovative bioinsecticides that provide environmentally friendly pest management solutions for farmers. The company focuses on creating natural single-domain antibody insecticides designed to enhance crop production while ensuring the safety of farm workers, consumers, and the environment. By utilizing advanced technology and fermentation processes, IBI-Ag offers efficient and selective pest control solutions that lower agricultural costs. The company's platform is built on thorough testing and extensive learning, allowing farmers to access customized biological pest control strategies that meet their specific needs. Through its commitment to sustainable practices, IBI-Ag aims to revolutionize the agricultural landscape by promoting safer and more effective methods of insect management.

ViAqua Therapeutics Ltd is an Israeli company founded in 2014 that specializes in developing innovative drugs and therapeutics for the aquaculture industry. The company focuses on creating the first orally administered treatment designed to combat viral diseases affecting aquatic species, particularly shrimp. ViAqua's proprietary platform employs a unique RNAi nanoparticle formulation that triggers a cellular response to disable viral infections. This technology enables the delivery of coated nanoparticles through feed or immersion techniques, enhancing the resistance of aquaculture species against viral epidemics. With a management team experienced in business development and industrial biotechnology, ViAqua aims to improve the health and sustainability of aquaculture practices.

PlanetWatchers, Inc. is a company based in San Francisco, California, that specializes in a platform for geospatial analytics focused on natural asset monitoring. Founded in 2016, PlanetWatchers provides a software-as-a-service solution designed for enterprises, governments, and NGOs across various sectors, including forestry, oil and gas. The company leverages advanced machine learning algorithms and synthetic aperture radar (SAR) technology to transform extensive manual data collection into rapid automated analysis. This capability enables organizations to efficiently monitor their natural assets, delivering critical insights that support the management of large-scale resources and enhance decision-making processes. By utilizing multi-source satellite sensors and elastic cloud infrastructure, PlanetWatchers facilitates effective monitoring and alerting systems that are essential for sectors such as crop insurance, improving accuracy and efficiency in claims validation.

ZygoFix is a medical device company focused on spine technology. It has developed a three-dimensional printed implant designed to lock the facet joint of the lumbar spine. This innovative device leverages the anatomy of the spine to provide stability, moving away from traditional external screw-based systems. By eliminating the need for pedicle screws, ZygoFix aims to reduce the risks associated with improper screw placement, enhancing patient safety and outcomes in spinal surgeries.

Limaca Medical is focused on advancing endoscopic ultrasound-guided biopsy techniques to enhance tumor diagnosis, particularly for gastrointestinal system tumors. The company has developed an electro-mechanically driven endoscopic device aimed at overcoming the limitations of existing biopsy methods, which often yield inadequate tissue samples for diagnostic testing. By providing high-quality core tissue for histopathologic analysis, Limaca Medical's innovation seeks to improve clinical outcomes for patients undergoing cancer diagnosis and treatment.

Phytolon Ltd, founded in 2000 and based in Misgav, Israel, specializes in the development of natural food colorants. The company has established a novel and sustainable technology that utilizes fermentation processes with baker’s yeast cells as biofactories to produce high-quality, plant-based food colors. This innovative approach provides a healthy alternative to synthetic food dyes, offering food manufacturers safe, cost-effective, and stable all-natural colors. Phytolon is dedicated to promoting human health and environmental sustainability through scientific advancement in the food color industry.

Vessi Medical is an Israeli medical device startup focused on innovating treatment for Non-Muscle-Invasive Bladder Cancer (NMIBC) through a novel surface cryotherapy approach. This method employs extreme cold to freeze and eliminate abnormal tissue, addressing the limitations of traditional first-line therapies like TransUrethral Resection of Bladder Tumor (TURBT), which can be invasive, costly, and often result in cancer recurrence. Vessi's technology offers a minimally invasive, office-based therapy that reduces the need for hospital stays and repeat surgeries, which are common in conventional treatments. The system comprises a standalone console and a disposable catheter that allows for targeted cell destruction while safeguarding healthy bladder tissue. Vessi Medical, supported by the Trendlines Group and led by experienced professionals in the medical device and cryotherapy fields, has already shown promising results in animal studies. The company's initial focus is on the $1.2 billion NMIBC market, with plans to expand into treatment options for overactive bladder and urinary tract infections in the future.

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

Insectta, founded in 2017, specializes in producing biomaterials derived from insects, targeting applications in various industries, including agrifood, pharmaceuticals, and electronics. The company aims to foster a circular economy in the insect farming sector by offering high-protein alternatives to traditional pet feeds and developing fertilizers for agricultural use. This innovative approach allows farmers to transform waste into valuable biomaterials, promoting sustainability and enhancing resource efficiency in farming practices.

AgroScout Ltd. is an Israeli company established in 2017 that specializes in developing an artificial intelligence-based platform aimed at enhancing sustainable farming practices. The company's technology provides precision agriculture solutions by utilizing advanced analytics and high-resolution aerial imagery to assess crop health and monitor for pests and diseases. AgroScout's platform supports farmers by offering insights on crop emergence, stand counts, canopy coverage, and biomass throughout the growing season. This continuous monitoring allows for early detection of infestations, enabling more effective curative treatments and reducing pesticide use. By delivering actionable insights into crop management and regional outbreak predictions, AgroScout aims to improve crop yields and profitability while fostering a more sustainable food production supply chain.

OrthoSpin Limited, founded in 2014 and based in Misgav, Israel, specializes in the development of an innovative robotic external fixation system designed to enhance treatment for patients with bone injuries and limb deformities. The company’s dynamic external fixators offer a significant improvement over traditional systems, which are often cumbersome and painful. OrthoSpin’s system features a lightweight motorized strut and a control box integrated into a circular hexapod fixation frame, allowing for automatic and continuous pre-programmed adjustments without requiring patient involvement. This smart system not only ensures adherence to prescribed treatment plans but also enables real-time monitoring of patient progress through proprietary software. By facilitating timely adjustments to treatment schedules, OrthoSpin aims to reduce complications and improve clinical outcomes for orthopedic patients, thereby accelerating their recovery process.

AlgaHealth specializes in the development of microalgal sources for high-quality fucoxanthin, a compound utilized in health and cosmetics. The company employs a novel microalgae cultivation algorithm that enhances efficiency by 15% to 50% and has established processing protocols to produce large quantities of natural fucoxanthin at a significantly reduced cost. In addition to fucoxanthin, AlgaHealth also aims to produce polysaccharides as a valuable by-product, contributing to a diverse range of high-value microalgal products. This innovative approach to growing microalgae inland and the use of unique microalgal strains positions AlgaHealth to meet the increasing market demand for quality additives in health supplements and skincare, while promoting sustainable biotechnology practices.

Equinom is a food-tech company focused on developing sustainable, non-GMO plant-based ingredients through innovative agricultural practices and advanced technology. It addresses the challenge of inadequate crop production for human consumption, as many crops are traditionally grown for animal feed, requiring costly processing to make them suitable for food. By leveraging its proprietary Manna™ technology platform, Equinom employs artificial intelligence to accelerate the development of high-yield, naturally bred crops that enhance the taste, nutrition, and affordability of meat and dairy alternatives. This approach not only ensures quality and consumer satisfaction but also promotes biodiversity and climate resilience, critical for future food security in the face of climate change. Collaborating with various partners, Equinom has gained recognition as a reliable supplier of premium ingredients, supported by notable investors that bolster its position in the rapidly growing plant-based food market.

AquiNovo is focused on addressing the expanding aquaculture industry, which is facing challenges due to the depletion of marine resources and rising fish consumption. The company develops feed additives that accelerate fish growth through a platform of non-genetically modified, non-hormonal peptides. These additives improve gut performance and health in fish, leading to higher production yields. Additionally, the technology has potential applications in treating gastrointestinal conditions in both production and companion animals. By providing sustainable solutions, AquiNovo aims to enhance fish farming practices and help meet the increasing global demand for fish protein.

ProJini Agchem is developing a solution focused on new type of molecular targets: protein-protein interactions. While such interactions are at the core of any organism, it is very challenging to develop inhibitors for such systems via conventional approaches due to their spatial and chemical characteristics. The platform, developed by scientists Maayan Gal, PhD and Itay Bloch at the Migal Galilee Research Institute Ltd., leverages a combination of computational-biophysical methods to tackle this significant challenge. ProJini Agchem received an exclusive license to use this platform to develop novel pesticides with new modes of action.

BioFishency Ltd. is an Israeli company that specializes in providing a plug-and-play water treatment system for land-based aquaculture. Founded in 2013 and based in Misgav, the company has developed a cost-effective, all-in-one solution that operates with various aquaculture methods, including extensive, intensive, and recirculated systems. BioFishency's technology addresses key challenges in aquaculture, such as limited water availability and the buildup of toxic ammonia, which can hinder fish growth and survival. By enhancing water conditions, the system allows fish farms to significantly increase production—potentially doubling or tripling yields—while utilizing existing infrastructure. This innovative approach not only boosts profitability for fish farmers but also promotes sustainability by minimizing ecological impact and reducing resource expenditures.

The Agency for Science, Technology and Research (A*STAR) is a Singaporean government agency established in 1991, dedicated to promoting scientific research and technological innovation. It oversees 18 research entities focused on biomedical sciences and physical sciences and engineering, primarily located in Biopolis and Fusionopolis. A*STAR plays a crucial role in advancing Singapore's economic sectors by providing essential intellectual, human, and industrial resources to industry partners. Additionally, the agency supports extramural research collaborations with universities, hospitals, and research centers, both locally and internationally, while nurturing talent and leadership within the research community.

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

AlgaHealth specializes in the development of microalgal sources for high-quality fucoxanthin, a compound utilized in health and cosmetics. The company employs a novel microalgae cultivation algorithm that enhances efficiency by 15% to 50% and has established processing protocols to produce large quantities of natural fucoxanthin at a significantly reduced cost. In addition to fucoxanthin, AlgaHealth also aims to produce polysaccharides as a valuable by-product, contributing to a diverse range of high-value microalgal products. This innovative approach to growing microalgae inland and the use of unique microalgal strains positions AlgaHealth to meet the increasing market demand for quality additives in health supplements and skincare, while promoting sustainable biotechnology practices.

ElastiMed Ltd. specializes in the development of innovative medical devices focused on compression therapy, specifically for treating Chronic Venous Insufficiency and preventing Deep Venous Thrombosis. Founded in 2015 and headquartered in Misgav, Israel, the company has created a wearable active compression device that employs advanced smart materials. This device, often referred to as a smart sock, uses electric pulses to compress and massage the legs, enhancing circulation and offering a comfortable and effective treatment solution. It aims to provide an affordable option for patients, particularly the elderly, to alleviate symptoms such as swelling, blood clots, leg ulcers, and sports injuries, thereby improving their overall quality of life.

FruitSpec Ltd. specializes in designing and manufacturing hyperspectral sensor systems for fruit yield estimation, catering to farmers, distributors, and insurance companies. Founded in 2016 and based in Tel Aviv, Israel, the company offers FruitSpec sensor pods that scan orchards to analyze fruit trees. This technology employs hyperspectral imaging and deep learning algorithms to differentiate between leaves and fruits, generating valuable insights for agribusinesses. FruitSpec provides a comprehensive yield estimation service, which includes scanning the orchard and delivering detailed reports. These reports feature the number of fruits and their size distribution, as well as heat maps indicating fruit quantity distribution within the orchard. By facilitating data collection and yield prediction, FruitSpec enables stakeholders in the fruit value chain to optimize their demand-to-supply processes and make informed business decisions.

Gordian Surgical Ltd. is a company based in Misgav, Israel, founded in 2012, that specializes in the development of laparoscopic surgical equipment. The company's flagship product, TroClose 1200, is an integrated port closure solution designed to facilitate the opening and suturing of the abdominal wall during laparoscopic procedures. Gordian Surgical holds three U.S. patents related to laparoscopic trocar, fascial closure systems, and suture anchor deployment methods. These innovations aim to provide surgeons with a simple, secure, and effective means of closing internal tissue layers, enhancing the safety and efficiency of laparoscopic surgeries. The company has developed an initial prototype and has plans to initiate preclinical trials to further test its technology.

EdenShield Ltd. is an Israel-based AgTech company founded in 2012, specializing in the development of nontoxic insect control products for greenhouse crops. The company offers a range of organic and chemical-free solutions, including EdenNet, EdenDirect, and EdenForte, which are formulated from botanical extracts and nutrients derived from native Israeli semi-desert plants. These products utilize proprietary aromatic ingredients that mask plant odors and reduce insect attraction, effectively preventing pest-related damage and the spread of viruses. EdenShield's innovative approach helps growers enhance the yield and health of crops, including cannabis, vegetables, and flowers, while promoting environmentally friendly agricultural practices.

MetoMotion is focused on creating a multipurpose robotic system called GRoW, aimed at addressing labor-intensive tasks in greenhouse vegetable production, particularly for greenhouse tomatoes. This innovative system utilizes artificial intelligence to identify and locate ripe fruit, significantly reducing the reliance on human labor and associated costs. Additionally, GRoW is designed to integrate seamlessly with existing farm systems, providing farmers with valuable insights that enhance yield and quality while minimizing waste. Through its technology, MetoMotion seeks to transform modern greenhouse operations and improve overall efficiency in agricultural practices.

Hargol™ FoodTech is the world's first commercial grasshopper farm! Grasshoppers are nature's most efficient protein source. Hargol™ FoodTech revolutionize the protein ingredient industry by providing a healthier and more sustainable and affordable alternative, becoming the leading intensive rearing company of grasshoppers in the world. The company is at the forefront of high quality nutrients and healthy grasshoppers supply to markets around the world, improving current market wild-harvested supply by providing year-round availability, nutrients content & quality and costs reduction. For its first line of products, Hargol FoodTech relies on methods and technologies of intensive breeding and growing of three grasshopper species that are processed into protein powders. The company is offering grasshopper based protein ingredient in North America markets to food/ingredient manufacturers and whole grasshoppers. Hargol™ FoodTech have thus far been attracting the interest of food producers, distributors and retailers in the North America, Europe and other regions of the world with whole grasshoppers, grasshopper’s nutrient-rich powder and innovative food products. With the expected 70% rise in demand for animal source protein over the next decades and with existing animal source protein taking a big toll on the environment there is a need for an alternative – Both sustainable and affordable for populations around the globe. Enhanced by their vegetarian diet grasshoppers’ nutrient content is superior compare to other insects or animal source protein: Over 70% whole protein, Omega-3 & Omega-6, Zinc, Iron, & Folic acid. Grasshoppers are also the only Kosher and Halal insect in the world!

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

EdenShield Ltd. is an Israel-based AgTech company founded in 2012, specializing in the development of nontoxic insect control products for greenhouse crops. The company offers a range of organic and chemical-free solutions, including EdenNet, EdenDirect, and EdenForte, which are formulated from botanical extracts and nutrients derived from native Israeli semi-desert plants. These products utilize proprietary aromatic ingredients that mask plant odors and reduce insect attraction, effectively preventing pest-related damage and the spread of viruses. EdenShield's innovative approach helps growers enhance the yield and health of crops, including cannabis, vegetables, and flowers, while promoting environmentally friendly agricultural practices.

Catalyst AgTech Ltd. is an innovative Israeli company focused on developing advanced technology for the agricultural sector. The company specializes in creating customizable catalysts that enhance the effectiveness of agrochemicals, such as pesticides, herbicides, and fungicides, while minimizing their environmental impact. Its patented technology features a self-destruction mechanism that ensures these chemicals break down after their intended use, significantly reducing the risk of groundwater contamination. By addressing the pressing issue of agrochemical pollution, Catalyst AgTech aims to reconcile the increasing demand for effective pest control with the necessity of environmental protection. Backed by scientific expertise from the Weizmann Institute of Science and supported by Trendlines Agtech – Mofet as a partner and investor, the company is positioned to contribute meaningfully to sustainable agriculture and drive significant business growth.

Valentis Nanotech, founded in 2013 and part of Trendlines Agtech, specializes in the development of polymeric films, coatings, and compounds. The company has patented a technology that utilizes cellulose nanocrystals combined with nanoparticles to create biodegradable, transparent films derived from plant pulp waste. These films exhibit enhanced strength, improved spectral control, and effective barriers against UV rays, oxygen, and moisture. Valentis collaborates with a leading agricultural thermoplastics company in Israel to advance product development, enabling the creation of tailored materials suitable for various applications across multiple industries. The innovative approach of Valentis positions it as a key player in the field of sustainable materials.

LapSpace Medical Ltd. is a company based in Misgav, Israel, that specializes in developing devices for laparoscopic surgery. Founded in 2011, it operates under the Misgav Venture Accelerator as part of The Trendines Group. The company has created an inflatable balloon retractor designed to enhance laparoscopic procedures by providing effective and gentle retraction of abdominal organs, such as the intestines. This innovative device minimizes the risk of complications, shortens operating times, eliminates the need for additional assistance, and reduces overall surgical expenses. Consequently, LapSpace Medical's technology enables patients to recover more quickly with minimal incisions.

ApiFix Ltd. develops a minimally invasive system for correcting scoliosis deformities, specifically targeting adolescents with Adolescent Idiopathic Scoliosis (AIS). Founded in 2011 and based in Misgav, Israel, the company focuses on patients classified as Lenke Type 1 or Type 5, who present with a Cobb angle between 35 and 55 degrees. The ApiFix system incorporates a miniature ratchet mechanism that allows for incremental corrections as the patient bends in the desired direction. This approach contrasts with traditional scoliosis surgeries, which typically involve a single, aggressive operation. Instead, ApiFix promotes a gradual correction process that extends over several months, supported by specialized physical therapy. As of April 2020, ApiFix operates as a subsidiary of OrthoPediatrics Corp.

MitrAssist is a company focused on developing innovative solutions for mitral valve regurgitation (MR). It has created a minimally invasive mitral valve implant that enhances the functionality of the natural mitral valve without causing damage. This unique "valve-in-valve" approach allows the implant to work in harmony with the existing valve, offering a treatment option that is neither a repair nor a replacement. MitrAssist's technology addresses the challenges associated with MR and aims to provide a more effective treatment solution for patients. By improving upon current minimally invasive methods, MitrAssist seeks to deliver significant advantages in patient care and outcomes.

Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy drug products that utilize living immune cells to treat cancer and infectious diseases. The company's product portfolio includes AlloStim, an infusion of activated T-Stim cells; CryoVax, an in-situ therapeutic cancer vaccine for patients with metastatic tumors; CRCL, which provides patient-specific tumor antigens; and AlloVax, an individualized anti-cancer vaccine aimed at educating the immune system during cancer remission to prevent recurrence. Immunovative Therapies is engaged in creating treatment protocols for various types of cancer, including hematological malignancies, prostate and breast cancers, glioblastoma multiforme, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. Established in 2004, the company has been supported by the Israel Office of the Chief Scientist and has participated in the Misgav Venture Accelerator program.

InnoLap Surgical develops a device for scarless laparoscopic procedures. The device comprises a handle, thin 3 mm needle, and 5-10 mm detachable and replaceable operating heads. The company was founded in 2012 and is based in Misgav, Israel. As of September 30, 2013, InnoLap Surgical Ltd. operates as a subsidiary of Teleflex Incorporated.

Polytouch Medical specializes in developing advanced technologies for minimally invasive laparoscopic surgery, focusing primarily on hernia repair solutions. Their flagship product, PatchAssist, enhances mesh deployment and placement techniques, particularly for ventral hernias, allowing for quicker treatment initiation and improving the chances of successful outcomes for patients. The company collaborates closely with physicians to refine its offerings, ensuring that products are aligned with clinical needs. Supported by dedicated employees, medical advisors, and a knowledgeable board, Polytouch Medical aims to significantly enhance the quality of care in surgical practices and improve patient outcomes through innovative medical solutions.

Nephera Ltd. is a development-stage medical device company based in Misgav, Israel, founded in 2008. The company specializes in an implantable pulse generator that protects and enhances kidney function in patients suffering from congestive heart failure (CHF) and acute heart failure. Nephera's innovative technology leverages electrical stimulation of the urinary tract to modulate sympathetic nerve activity, which helps maintain renal function and improve the effectiveness of diuretic therapy. This treatment addresses a critical need in managing kidney dysfunction during the frequent hospitalizations of CHF patients, ultimately aiming to preserve kidney health and improve patient outcomes.

Inspiro Medical Ltd. is a medical device company focused on creating an advanced inhalation platform for the delivery of various therapeutic agents. This platform is designed to administer both small molecules, such as corticosteroids and beta agonists, as well as larger macromolecules, including antibodies and vaccines. The company is currently conducting clinical trials involving its proprietary dry powder inhaler, Inspiromatic, specifically targeting asthmatic children. Through its innovative approach, Inspiro Medical aims to enhance treatment options for patients with respiratory diseases.

Stimatix GI is an early-stage startup founded in June 2009, operating under the Misgav Venture Accelerator and jointly funded by the Office of the Chief Scientist. The company has developed a product line known as the Artificial Ostomy Sphincter (AOS), which includes the AOS-1000 and AOS-C2000. These innovative colostomy devices provide patients with the ability to control bowel evacuation, significantly improving their quality of life. The AOS products are designed to seal the stoma, eliminating the issues associated with traditional adhesive bags, and offer a low-profile, aesthetically pleasing solution. By providing users with the autonomy to decide when and where to evacuate, these devices simplify the evacuation process, making it quicker and cleaner. Additionally, the hermetic seal of the AOS products helps prevent skin irritation and folliculitis, addressing common discomforts associated with ostomy care.

ETView Medical Ltd. specializes in innovative airway management solutions by integrating continuous direct airway visualization into its products. The company manufactures single-use endotracheal tubes, both single and double-lumen, which are equipped with a high-resolution video imaging system. This technology is particularly beneficial for medical professionals dealing with challenging intubation scenarios, as it enhances visibility and control during procedures. ETView's product line includes various imaging systems, such as the VivaSight SL and DL, designed to improve patient safety and outcomes in airway management.

The URINFO 2000 fluid monitoring system is the only feasible solution for the accurate, real-time, and continuous monitoring of urine output. The product is based on FlowSense’s patented optical flow sensing technology. URINFO2000 has been used in the critical care setting to optimize fluid and electrolyte balance, treat acute kidney injury, and prevent renal failure.

VivoText is a digital speech platform specializing in expressive speech creation tailored for the entertainment and media sectors. By utilizing advanced text-to-speech technology, VivoText enables content creators to produce high-quality narration, voiceovers, and complex spoken content with a focus on personalization and scalability. The platform allows for the crafting of virtual human voices, which provides unique interactivity and ensures that creators maintain control over the emotional expression and nuances of the speech output. This innovative approach empowers professionals in industries such as publishing, gaming, and marketing to engage deeply in the speech creation process, ultimately enhancing the impact of their content. With tools that allow for the cloning of voices and the production of lifelike digital speech, VivoText meets the growing demand for customizable audio solutions.

LifeBond Ltd. specializes in the development and manufacturing of absorbable bio-surgical medical devices aimed at enhancing tissue repair and improving patient recovery. The company's flagship product, LifeSeal, is designed to reinforce staple lines in bariatric and colorectal surgeries, helping to minimize complications such as leakage. Another key product, LifeMesh, is a self-fixating mesh intended for hernia repair, providing secure fixation and reducing post-surgical issues. LifeBond also focuses on the development of tissue adhesives and absorbable hemostats. Founded in 2006 and based in Caesarea, Israel, the company offers its innovative medical solutions across various international markets, including the United States, Europe, and China. Although LifeSeal and LifeMesh are currently investigational and not yet approved for sale, they represent significant advancements in addressing unmet surgical needs.

BioSight is a biopharmaceutical company focused on developing innovative cancer-targeted chemotherapy pro-drugs. Founded in 2000 and based in Lod, Israel, BioSight has developed a technology known as S2DOT, which allows for the targeted delivery of chemotherapy drugs directly into cancer cells. This approach significantly reduces the systemic toxicity often associated with traditional chemotherapy treatments. The company’s lead product is a non-toxic conjugate of cytarabine and asparagine, designed specifically for the treatment of acute myeloid leukemia. Through its research and development efforts, BioSight aims to provide safe and effective therapeutic options for patients suffering from hematological malignancies and disorders.

Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy drug products that utilize living immune cells to treat cancer and infectious diseases. The company's product portfolio includes AlloStim, an infusion of activated T-Stim cells; CryoVax, an in-situ therapeutic cancer vaccine for patients with metastatic tumors; CRCL, which provides patient-specific tumor antigens; and AlloVax, an individualized anti-cancer vaccine aimed at educating the immune system during cancer remission to prevent recurrence. Immunovative Therapies is engaged in creating treatment protocols for various types of cancer, including hematological malignancies, prostate and breast cancers, glioblastoma multiforme, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. Established in 2004, the company has been supported by the Israel Office of the Chief Scientist and has participated in the Misgav Venture Accelerator program.