Empirical Ventures

OSSTEC specializes in advanced orthopedic implants, focusing on knee replacement surgeries. Its metal 3D printed implants mimic natural bone structure, reducing stress shielding, promoting bone ingrowth, and enhancing long-term implant stability for patients with osteoarthritis.

Founded in Sheffield, Exciting Instruments combines software expertise from Bulldozer Limited with Dr. Timothy Craggs' single molecule knowledge to streamline discovery processes in biophysics, life sciences, drug discovery, and medical diagnostics. Their spectroscopy tool studies protein conformations and bimolecular interactions, offering real-time data analysis and visualization via cloud connectivity.

Silveray develops affordable large-area direct conversion detectors for the X-ray imaging market.

MintNeuro is a healthcare company focused on advancing neuroscience through the development of minimally invasive neural implants. These innovative devices are designed to both sense and modulate brain activity, aiming to treat various neurological conditions with greater precision and reduced invasiveness. By creating a platform technology for small implantable devices, MintNeuro seeks to enhance patient outcomes and improve the overall performance of treatments in the field of neurology. The company's commitment to leveraging microtechnology and implantable neural interfaces positions it at the forefront of neurological healthcare solutions.

Argonaute RNA specializes in developing therapeutic solutions based on RNA interference (RNAi). Its proprietary technology involves modifying small interfering RNA (siRNA) for safe and effective gene silencing, targeting specific proteins to treat life-threatening diseases.

Signapse develops real-time sign language translator software using artificial intelligence. Their platform aims to improve accessibility and inclusivity by providing instant translations, supporting video content integration. This enables organizations to communicate effectively with deaf individuals.

Neuronostics Ltd is a spin-out from the University of Exeter in the UK, dedicated to developing and commercializing innovative technology for assessing seizure susceptibility. The company has created a novel platform that focuses on diagnosing and prognosticating neurological conditions, specifically targeting epilepsy. Utilizing a patented seizure risk score derived from routine electroencephalogram (EEG) recordings, Neuronostics' technology aims to facilitate early diagnosis and prognosis of epilepsy. This advancement is designed to empower clinicians to enhance patient care and improve the quality of life for individuals living with this neurological condition.

WASE is a London-based company founded in 2017, specializing in decentralized sanitation solutions aimed at promoting the global adoption of circular waste treatment. The company focuses on enhancing energy recovery from previously non-viable waste streams through its innovative waste-to-energy technology. In addition to energy recovery, WASE's system facilitates the recovery of water and nutrients, allowing for the production of fertilizers. By transforming waste into valuable resources, WASE empowers clients to harness the potential of waste to support sustainable practices and drive future growth.

MitoRx Therapeutics is a biotechnology company focused on developing therapeutics that reverse mitochondrial dysfunction. It is developing small molecule therapies for weight loss with muscle preservation in obesity-related and cardiometabolic conditions. The company is advancing mitochondrial-targeted persulfide modifiers intended to restore a signaling mechanism identified in population studies. Preclinical data indicate efficacy against hepatosteatosis, potential as a monotherapy, and enhanced fat loss with lean mass gain when combined with glucagon-like peptide-1 receptor agonists.

Albotherm specializes in the development and manufacturing of innovative passive cooling polymer coatings aimed at addressing climate change and its impacts. The company's core technology involves a smart transitioning coating that regulates surface temperatures without requiring energy input. This coating transitions reversibly from clear to white when temperatures exceed a specified trigger point, effectively reflecting unwanted light and preventing overheating. By offering this unique solution, Albotherm serves various industries seeking to enhance thermal management and reduce energy consumption associated with cooling.

Zentraxa is a biotechnology company specializing in the design, production, and testing of innovative synthetic biopolymers. Utilizing its proprietary technology platform, Zentide, the company advances the capabilities of peptide synthesis by overcoming traditional bio-design limitations through a universal manufacturing process. Zentraxa's biopolymers are engineered to support diverse medical applications, including the development of biological adhesives. This unique approach allows clients to enhance their research and development efforts, positioning Zentraxa as a leader in the field of synthetic biopolymers.

OSSTEC specializes in advanced orthopedic implants, focusing on knee replacement surgeries. Its metal 3D printed implants mimic natural bone structure, reducing stress shielding, promoting bone ingrowth, and enhancing long-term implant stability for patients with osteoarthritis.

EnsiliTech is a biopharmaceuticals company focused on preserving the integrity of vaccines and other biological materials. The company has developed a novel ensilication technology that utilizes protective silica nanoshells to shield vaccine components from environmental degradation. This innovative approach aims to prevent vaccine spoilage, thereby enhancing the shelf-life of these critical biological products. By improving the stability and accessibility of vaccines, EnsiliTech seeks to reduce waste and contribute to global vaccination efforts, ensuring that more people can benefit from life-saving immunizations.

QV Bioelectronics develops an innovative electric field therapy implant, GRACE, designed to extend the lives of brain tumor patients while maintaining their quality of life. This first-of-its-kind device targets glioblastoma, a cancer with poor outcomes, by slowing tumor growth and sparing healthy tissue.

cheMastery Group Ltd. is a Glasgow‑based company founded in 2019 that develops laboratory automation technology for the chemical sector. Its systems streamline experimental workflows, enabling scientists to conduct research, development, and manufacturing more efficiently and reliably. By integrating robotics, software, and data management, the company builds the infrastructure that supports modern chemistry laboratories. The technology is designed to reduce manual handling, improve reproducibility, and accelerate the pace of discovery in natural science and engineering.

Transdermal Diagnostics is a technology platform focused on the prevention, diagnosis, and management of chronic conditions, starting with diabetes. It offers a wearable system that provides needle-free, continuous glucose monitoring through affordable disposable patches, enabling people with diabetes and prediabetes to gain biological insights and make informed decisions for healthier living.

Muddy Machines develops autonomous robots aimed at assisting farms with labor-intensive crops. The company's primary focus is on enhancing its technology for harvesting green asparagus, while also exploring applications for other crops. Utilizing computer vision and machine learning, Muddy Machines' robotics platform enables precise harvesting by predicting crop maturity and selectively gathering produce, minimizing damage and ensuring freshness. In addition to harvesting, the company is investigating other labor-intensive agricultural tasks, such as weeding and precision applications, to further support farmers in improving efficiency and productivity in their operations.

MitoRx Therapeutics is a biotechnology company focused on developing therapeutics that reverse mitochondrial dysfunction. It is developing small molecule therapies for weight loss with muscle preservation in obesity-related and cardiometabolic conditions. The company is advancing mitochondrial-targeted persulfide modifiers intended to restore a signaling mechanism identified in population studies. Preclinical data indicate efficacy against hepatosteatosis, potential as a monotherapy, and enhanced fat loss with lean mass gain when combined with glucagon-like peptide-1 receptor agonists.

WASE is a London-based company founded in 2017, specializing in decentralized sanitation solutions aimed at promoting the global adoption of circular waste treatment. The company focuses on enhancing energy recovery from previously non-viable waste streams through its innovative waste-to-energy technology. In addition to energy recovery, WASE's system facilitates the recovery of water and nutrients, allowing for the production of fertilizers. By transforming waste into valuable resources, WASE empowers clients to harness the potential of waste to support sustainable practices and drive future growth.

Anaphite is a Bristol, United Kingdom-based company that develops graphene-based nanomaterials. Established in 2016, it focuses on graphene-enhanced cathodes for high-power, high-energy, low-cost lithium-ion batteries. Its nanomaterials are produced by incorporating graphene into composite materials through an inexpensive, scalable process, enabling a range of applications. Beyond energy storage, the technology is positioned to support air purification and thermal management, offering materials with advanced properties at low cost.

Argonaute RNA specializes in developing therapeutic solutions based on RNA interference (RNAi). Its proprietary technology involves modifying small interfering RNA (siRNA) for safe and effective gene silencing, targeting specific proteins to treat life-threatening diseases.