Enlivex Therapeutics

Enlivex Therapeutics Ltd. is a clinical-stage immunotherapy company headquartered in Nes Ziona, Israel, focused on developing allogeneic drugs aimed at rebalancing the immune system. The company's lead product, Allocetra, is an immunotherapy candidate currently undergoing multiple clinical trials. These include a Phase IIb trial for severe sepsis, an investigator-initiated Phase II trial for COVID-19 patients in severe and critical conditions, and a Phase IIa trial for preventing Graft Versus Host Disease in patients undergoing allogeneic hematopoietic stem cell transplants. Additionally, Enlivex is exploring Allocetra's potential in preventing complications from bone marrow transplants and acute multiple organ failure. The company also aims to develop cell-based therapies that enhance the efficacy of treatments for solid tumors through immune checkpoint rebalancing. Founded in 2005 by Professor Dror Mevorach, Enlivex utilizes a novel approach that focuses on inducing immune tolerance by employing apoptotic cells to modulate inflammatory and autoimmune responses.