Threshold Impact

Variational AI employs cutting-edge machine learning techniques to swiftly generate novel compounds optimized for multiple properties. This approach aims to mitigate common causes of drug failure and enhance clinical success. The company collaborates with leading biopharmaceutical partners and maintains its own pipeline.

Modality.AI, Inc. is a healthcare technology company based in San Francisco, California, founded in 2018. It specializes in AI-powered solutions that enhance the efficiency of clinical trials for neurological and mental health therapies. The company's platform utilizes conversational AI to engage patients through naturalistic spoken interaction, allowing for continuous health assessments anytime and anywhere. By analyzing multimodal data, including audio-visual biomarkers, Modality.AI provides objective measures that correlate with clinical outcomes. This innovative approach enables pharmaceutical companies to conduct self-driven assessments and improve the monitoring of health conditions, ultimately facilitating more effective clinical trials.

FluidAI is a medical technology company focused on post-operative care, combining artificial intelligence with in-body data to improve patient monitoring. The company develops a smart catheter system that enables proactive post-operative care by detecting complications at onset and delivering critical health data to healthcare providers ahead of time.

ResVR is a B2B Proptech company that specializes in providing software solutions for small and medium-sized home builders. Their core product is a 3D imaging technology that digitizes home drawings and integrates them into a customizable software platform. This allows builders and homebuyers to visualize and customize home designs, enabling more efficient processes, cost savings, and improved customer satisfaction.

Nimble Science Ltd. is a digital health company focused on revolutionizing gastrointestinal (GI) health through its innovative SIMBA capsule technology. This end-to-end platform facilitates multi-omic mapping of the GI tract, allowing for the passive sampling of small bowel luminal fluid. By leveraging this advanced sampling method, Nimble Science provides precision datasets that offer valuable insights into GI health, thereby transforming the diagnosis and treatment of gastrointestinal conditions. The company's approach enables healthcare providers to directly sample and analyze targeted regions of the GI tract, marking a significant advancement in the understanding and management of GI health.

Founded in 2014, Arbutus Medical develops and manufactures surgical power tools aimed at reducing healthcare costs. Its flagship product is a radically affordable orthopedic power tool system used in trauma centers, veterinary hospitals, military deployments, and hospitals worldwide.

Modality.AI, Inc. is a healthcare technology company based in San Francisco, California, founded in 2018. It specializes in AI-powered solutions that enhance the efficiency of clinical trials for neurological and mental health therapies. The company's platform utilizes conversational AI to engage patients through naturalistic spoken interaction, allowing for continuous health assessments anytime and anywhere. By analyzing multimodal data, including audio-visual biomarkers, Modality.AI provides objective measures that correlate with clinical outcomes. This innovative approach enables pharmaceutical companies to conduct self-driven assessments and improve the monitoring of health conditions, ultimately facilitating more effective clinical trials.

FluidAI is a medical technology company focused on post-operative care, combining artificial intelligence with in-body data to improve patient monitoring. The company develops a smart catheter system that enables proactive post-operative care by detecting complications at onset and delivering critical health data to healthcare providers ahead of time.

PulseMedica is a medical device company based in Edmonton. It develops non-invasive, automated image-guided laser treatments for vitreoretinal diseases using 3D computer vision and femtosecond laser technology.

Optimity Inc. is a Toronto-based company that operates a corporate wellness platform designed to enhance employee engagement through the practice of micro-habits. The platform encourages users to take short breaks ranging from 30 seconds to two minutes to engage in activities that improve their mood, focus, and social connections. It offers a diverse range of micro-habits, including stress-relief exercises, stretches, mindfulness practices, and wellness tips related to nutrition and financial health. Targeting a wide array of professionals, from office workers to retail employees and traveling sales associates, Optimity provides tools that promote proactive health coaching and support. Additionally, its proprietary Optimity Health Grade utilizes wearable data to assess key health factors, offering personalized programs to improve health outcomes and modernize the insurance industry. Through its technology solutions, Optimity helps clients in the insurance and health sectors engage and reward their members and employees for adopting healthy habits.

Rehabtronics specializes in developing medical devices aimed at aiding recovery from neurological issues such as stroke and spinal cord injury. Their product suite includes intermittent electrical stimulation technology designed to reduce pressure and enable patients to recover through simple, effective treatments.

Swiftsure Innovations provides registered nurses with the tools required to improve patient outcomes. It develops a medical device that enhances oral care for patients on life support with the aim of decreasing the incidence of ventilator-acquired pneumonia, length of mechanical ventilation, and length of hospital stay. Creative Destruction Labs supports the company.

PulseMedica is a medical device company based in Edmonton. It develops non-invasive, automated image-guided laser treatments for vitreoretinal diseases using 3D computer vision and femtosecond laser technology.

Fluid Biomed is a medical device start-up specializing in the development of an innovative implantable dissolving stent aimed at treating brain aneurysms. Founded by a team of neurosurgeons, the company focuses on enhancing patient outcomes by offering a bio-absorbable polymer-based flow-diverting stent that gently redirects blood flow to facilitate the healing of weakened blood vessels. This advanced medical device is designed to minimize the need for invasive procedures, allowing physicians to efficiently and effectively treat patients while reducing the risk of stroke. Through its pioneering approach, Fluid Biomed is poised to contribute significantly to the field of neurosurgery and improve the quality of care for individuals with brain aneurysms.

Hyivy Health specializes in innovative pelvic rehabilitation solutions. Its flagship product is an intelligent device designed for women experiencing pelvic health complications, offering quantifiable data tracking and three different therapies to enhance recovery and comfort.

FluidAI is a medical technology company focused on post-operative care, combining artificial intelligence with in-body data to improve patient monitoring. The company develops a smart catheter system that enables proactive post-operative care by detecting complications at onset and delivering critical health data to healthcare providers ahead of time.

DrugBank is a leading provider of pharmaceutical knowledge databases. It offers an extensive suite of products powered by the world's most comprehensive and up-to-date drug information. The company enables businesses to enhance healthcare delivery through precision medicine and clinical software applications, while also facilitating drug discovery through data science. DrugBank's structured datasets are used for uncovering novel drug candidates, identifying repurposing opportunities, and building predictive machine learning models. Additionally, DrugBank Online, a publicly available resource, offers limited datasets for academic and non-commercial researchers.

A&K Robotics Inc. is a Canadian company based in Vancouver, founded in 2015, that specializes in designing and building advanced robotic systems. The company focuses on developing intelligent navigation systems that enable robots to work collaboratively with humans. A&K Robotics also creates electric micro-mobility platforms and self-driving robotic pods, which aim to enhance mobility in large facilities such as airports, malls, and museums, as well as in crowded urban environments. By pushing the boundaries of robotics technology, A&K Robotics seeks to improve quality of life and promote environmental sustainability through innovative real-life applications.

Nimble Science Ltd. is a digital health company focused on revolutionizing gastrointestinal (GI) health through its innovative SIMBA capsule technology. This end-to-end platform facilitates multi-omic mapping of the GI tract, allowing for the passive sampling of small bowel luminal fluid. By leveraging this advanced sampling method, Nimble Science provides precision datasets that offer valuable insights into GI health, thereby transforming the diagnosis and treatment of gastrointestinal conditions. The company's approach enables healthcare providers to directly sample and analyze targeted regions of the GI tract, marking a significant advancement in the understanding and management of GI health.

HeadCheck Health is a digital health company delivering concussion management and risk mitigation technologies for sports organizations. Its suite of tools streamlines execution and monitoring of concussion protocols across levels and sports, including education, testing, documentation, and return-to-play management, with tailored workflows to align with league policies and applicable laws. The solution enables stakeholders including athletes, parents, coaches, and organizations to track injury reports and generate customized insights to reduce injury risk and financial exposure associated with neurological injuries.