Friále

Friále is a venture capital firm based in San Francisco that invests in startups around the world, with a focus on medical equipment and technology. It typically makes seed-stage investments and aims to participate in follow-on rounds as portfolio companies grow. The firm emphasizes a founder-led approach, drawing on founders’ own experience to guide investment decisions.

Bryan Frist

Managing Partner

29 past transactions

Standard Practice

Seed Round in 2022
Standard Practice is a healthcare payment platform designed to enhance financial interactions for providers and patients. The company offers a seamless payment system that leverages fintech and voice AI technology, allowing medical practices to automate communications with insurance companies and pharmacies. By eliminating the need for providers to engage in cumbersome insurance calls, Standard Practice aims to streamline operations and improve employee satisfaction. Additionally, the platform provides zero-fee and zero-interest financing options, enabling patients to manage their healthcare expenses more effectively. Through these innovative solutions, Standard Practice serves as a valuable resource for healthcare providers, enhancing their operational efficiency and patient engagement.

Myria

Pre Seed Round in 2022
Annually, the wealthiest 300,000 people spend $1.3 million each on their lifestyle, but still struggle to find everything they want. - The most sought-after products, services, and experiences are never listed online. - Private events, private clubs, and numerous other categories are not accessible. - The best people don't need the web to find clients or jobs. Myria is a private marketplace & community where all participants are fully vetted. Our offers are exclusive and otherwise unavailable online. Myria helps off-market sellers reach the nicest, richest, and most quailed buyers on Earth. In turn, we help the world’s most successful people find the best of everything and get the most out of life.

Spring in Africa

Seed Round in 2020
Spring in Africa is a fnacial service offering firm that provides banking alternatives to make transection efficient.

Eze

Pre Seed Round in 2020
Eze is a B2B marketplace that facilitates the buying and selling of electronic commodities, specifically targeting telecommunication and global electronic wholesalers. By providing a platform for these wholesalers to trade devices in wholesale quantities, Eze aims to streamline the fragmented second-hand electronics market, which is estimated to be worth $46 billion. The marketplace offers real-time market data, enabling users to make informed decisions and potentially profit from their transactions. Through this innovative approach, Eze seeks to address inefficiencies in the electronic trading sector.

BillionToOne

Series A in 2020
BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

C16 Biosciences

Series A in 2020
C16 Biosciences develops palm oil alternatives through microbial fermentation, producing high-performance lipids and oils to replace palm-derived ingredients in food, beauty, and consumer products. Using its fermentation platform, the company aims to deliver sustainable ingredients without conventional palm oil supply chains, reducing environmental impact. It markets Palmless, a platform for sustainable ingredients, and has introduced Torula oil, a bioactive oil with reported benefits for skin and hair health. Founded in 2017 and based in New York, C16 Biosciences serves food manufacturers, refiners, traders, and brands by providing reliable, environmentally friendly ingredients across beauty, personal care, home care, and food markets.

Elpha

Seed Round in 2019
Elpha, Inc. is an online platform specifically designed to support women in the technology sector. Incorporated in 2019 and based in Oakland, California, Elpha fosters a private community where members can engage in candid discussions on various personal and professional topics. The platform features a daily feed of member-generated conversations, enabling women to collaborate on projects, seek advice, and explore career opportunities. Additionally, it offers resources for learning from industry experts and networking with peers. Membership is free, promoting an inclusive environment where women can build connections, enhance their careers, and share insights on a diverse range of subjects, including startup challenges and fundraising issues.

Lively

Series B in 2019
Lively, Inc. is a health savings account (HSA) platform designed for both employers and individuals. Established in 2016 and headquartered in San Francisco, California, Lively offers a user-centric solution that enhances the experience of managing HSAs. Its platform enables consumers to optimize their healthcare spending and maximize savings, ultimately improving their overall financial well-being. By providing an intuitive interface, Lively aims to simplify healthcare management for users, making it easier for them to navigate HSA-compatible plans.

Pair Team

Seed Round in 2019
Pair Team provides healthcare coordination services focused on underserved and vulnerable communities. It deploys a dedicated, tech-enabled care team—including community health workers, registered nurses, and behavioral health clinicians—to offer personalized, holistic support to Medicaid and Medicare patients and other low-income individuals facing barriers to care such as transportation, housing and food insecurity, and limited mobile access. The company acts as an extension of safety-net primary care systems, helping them deliver patient-centered care while integrating with community-based organizations. It is building a care delivery platform to standardize clinical practices, streamline administrative tasks, and enable clinicians to spend more time with patients.

Handle

Seed Round in 2019
Handle is a construction software company that provides an end-to-end platform to streamline payments and project administration. Its tools automate tasks related to late payments, lien management, deadline tracking, mailings, and document management, enabling contractors and material suppliers to be paid faster. The software supports credit and finance teams with online payments, waivers, and access to capital, consolidating workflows for invoices and documents. By digitizing owner verification, required documents, electronic signatures, and related communications, Handle helps construction projects run smoothly and reduce payment delays. Based in La Jolla, California.

Inscribe

Seed Round in 2018
Inscribe offers a way for fintech and financial services organizations to automate their manual reviews, reduce fraud losses, and increase decision accuracy. By automating document reviews and improving fraud detection, companies can increase efficiency and reduce operational costs. Founded in 2017, Inscribe is trusted by leading companies like BlueVine, Petal, Fair, and Ramp. With investors from Y Combinator, Uncork Capital, Crosslink Capital, and Foundry Group, Inscribe has a global footprint with locations in North America and Europe.

Entocycle

Seed Round in 2018
Entocycle Ltd, established in 2014 and headquartered in London, specializes in producing insect-based protein for animal feed. The company cultivates black soldier fly larvae in an automated system that monitors and analyzes their growth and environment. Entocycle sources organic waste from farms, factories, and catering industries to mass-produce insects as a sustainable protein source. It supplies its products primarily to feed suppliers, retailers, food, and agricultural industries, aiming to accelerate the global transition towards sustainable protein.

Medinas

Seed Round in 2018
Medinas, Inc. is a technology-driven company that operates a data-driven marketplace designed for healthcare organizations to buy and sell surplus and short-date medical supplies and equipment. Founded in 2017 and headquartered in Berkeley, California, Medinas serves a range of clients, including hospitals, ambulatory surgical centers, veterinary practices, and nursing homes, alongside original equipment manufacturers. The company's platform features a cloud-based asset management solution that streamlines the sales process, enabling healthcare entities to efficiently resell and redeploy pre-owned medical equipment. With a mobile-enabled interface and a pricing engine that manages offers from multiple buyers, Medinas helps optimize clinical asset disposition programs, ultimately saving time and money for its users.

Tizeti

Series A in 2018
Tizeti Inc., established in 2016 with headquarters in Oakland, California, specializes in delivering unlimited broadband internet services across Africa. The company focuses on densely populated urban areas, utilizing Wi-Fi's large wireless capacity and the decreasing cost of solar panels to create a low-cost network infrastructure. Tizeti offers affordable, customer-friendly pricing for its services, which include internet protocol television, voice-over-internet protocol, and wireless internet access via Wi-Fi technology.

HeyDoctor

Seed Round in 2018
HeyDoctor is an online healthcare provider that offers accessible and affordable medical services for common health issues. The company allows users to initiate consultations at their convenience, often completing visits in as little as five minutes without the need for insurance. Its range of services includes UTI testing, acne diagnosis, cold sore management, birth control prescriptions, HIV testing, erectile dysfunction treatment, and smoking cessation support. By enabling users to communicate with doctors through text messaging, HeyDoctor aims to streamline the healthcare experience, eliminating the need for traditional waiting rooms and providing timely medical attention.

C16 Biosciences

Seed Round in 2018
C16 Biosciences develops palm oil alternatives through microbial fermentation, producing high-performance lipids and oils to replace palm-derived ingredients in food, beauty, and consumer products. Using its fermentation platform, the company aims to deliver sustainable ingredients without conventional palm oil supply chains, reducing environmental impact. It markets Palmless, a platform for sustainable ingredients, and has introduced Torula oil, a bioactive oil with reported benefits for skin and hair health. Founded in 2017 and based in New York, C16 Biosciences serves food manufacturers, refiners, traders, and brands by providing reliable, environmentally friendly ingredients across beauty, personal care, home care, and food markets.

Groww

Seed Round in 2018
Groww is a Bengaluru-based investment platform founded in 2017 by Lalit Keshre, Harsh Jain, Neeraj Singh, and Ishan Bansal. It offers users direct access to invest in mutual funds, gold, and US stocks via its simplified, paperless interface. The platform leverages data science to provide insights and facilitate systematic investment planning, making it accessible for new investors. Additionally, Groww allows users to apply for personal loans and pay bills through their application.

Porter Road Butcher

Seed Round in 2018
Porter Road is a omnichannel whole animal butcher changing the broken food system, by working directly with farmers to offer exceptional, sustainably raised meat direct to consumer. The company was founded by James Peisker and Chris Carter.

Medumo

Seed Round in 2018
Medumo, Inc. is a healthcare technology company based in Boston, Massachusetts, founded in 2013. It specializes in automating the delivery of timely instructions to patients through its CareTours platform, which utilizes automated messaging via SMS and email. By integrating mobile communication and artificial intelligence, Medumo empowers healthcare organizations to engage patients effectively without requiring additional resources. The platform allows patients to seek medical advice, manage health records, and receive precise instructions, thereby enhancing patient-provider communication. Medumo aims to improve patient preparedness and reduce the administrative burden on healthcare staff, ultimately fostering a more transparent and informed healthcare environment. The company operates as a subsidiary of Koninklijke Philips N.V. since 2019.

Aella

Seed Round in 2017
Aella is a financial technology company that provides instant credit solutions aimed at simplifying the borrowing process for employees. By partnering with employers, Aella allows individuals to access loans at competitive rates without the complexities of traditional loan applications. The platform is designed to serve underbanked users, offering a range of financial services focused on lending. Aella's debt-as-a-service model facilitates quick access to funding through collaborations with agency banks, enabling users to obtain cash efficiently. The company operates offices in the United States and Nigeria, catering to both employees and employers.

BillionToOne

Seed Round in 2017
BillionToOne Inc. is a precision diagnostics company focused on developing advanced genetic testing platforms that detect and quantify diseases at the molecular level. Established in 2016 and headquartered in Menlo Park, California, the company offers a noninvasive prenatal screening solution called UNITY, which analyzes fetal cell-free DNA from a single blood sample provided by the mother. This test can identify single-gene disorders such as cystic fibrosis, spinal muscular atrophy, and thalassemia, thereby providing a safer alternative to invasive procedures like amniocentesis. Beyond prenatal diagnostics, BillionToOne is also developing oncology assays that enable the detection of actionable mutations and monitor tumor burden through blood samples, allowing for more precise therapy selection and monitoring. The company's innovative technologies aim to make genetic testing both accurate and accessible, ensuring that a broader spectrum of patients can benefit from advanced medical diagnostics.

Muzz

Seed Round in 2017
Muzz is a leading online matchmaking platform designed specifically for Muslims seeking marriage. With over 8 million members and more than 400,000 successful matches, the application addresses the unique cultural values of Muslims, who prioritize marriage over dating. Founded by Shahzad Younas, a former investment banker, Muzz aims to transform the way Muslims connect and build relationships. The platform allows users to create personal profiles, engage in private chats, send friend requests, share photos, and plan meet-ups, fostering meaningful connections among Arab and Muslim singles. Headquartered in Aldgate, London, Muzz has a rapidly growing team of over 65 professionals and has received significant investment from notable Silicon Valley and global investors. As the first Muslim-centric startup backed by a prestigious accelerator, Muzz has gained considerable media attention, highlighting its impact on the untapped global Muslim demographic.

Humi

Seed Round in 2017
Humi is a cloud-based software platform that automates human resources processes, offering a comprehensive solution for businesses. The platform streamlines various HR functions, including employee recruiting and onboarding, time-off tracking, scheduling, payroll management, and benefits administration. Additionally, it provides tools for performance monitoring and reporting, allowing organizations to enhance efficiency and modernize their human resource management. By integrating these essential functions into one platform, Humi enables businesses to simplify their HR operations and improve overall workforce management.

Shield Bio

Seed Round in 2017
Shield Bio is a biotechnology company focused on combating antibiotic resistance, a growing public health crisis projected to surpass cancer-related deaths by 2050. The company has developed a novel genomic testing platform that enables sexually transmitted infection (STI) clinics to accurately identify antibiotic-resistant strains of pathogens, particularly gonorrhea, which has shown resistance to multiple antibiotics. With approximately 820,000 new gonorrhea infections annually in the United States and the Centers for Disease Control and Prevention designating resistant strains as an urgent threat, Shield Bio's rapid and precise molecular antibiotic susceptibility testing is critical. This platform allows healthcare providers to determine the most effective antibiotics for treatment, thereby enhancing patient outcomes and helping to curb the spread of antibiotic resistance.

Validere

Seed Round in 2016
Validere Technologies Inc. is a Toronto-based company that specializes in providing critical information about liquids through innovative measurement, reporting, and verification solutions. Founded in 2015, Validere develops portable devices, including the Validere Identifier, which assesses the hazardous nature of liquids by referencing a comprehensive library. Additionally, the company offers EDGE Connect, a platform that facilitates secure connections between buyers and sellers, enabling the discovery of arbitrage opportunities. Validere's main focus is on liquid fingerprinting, industrial process monitoring, and optimizing logistics within the energy sector. By delivering accessible and verifiable testing data, Validere aids organizations in making informed business decisions and enhances the accuracy of crude oil testing, ensuring accountability and quality across operations. The company's expertise in emissions management and tracking further positions it as a valuable partner for energy companies seeking to improve their financial and environmental performance.

Innov8 Coworking

Seed Round in 2016
Innov8 Coworking is a Y-Combinator backed startup based in India that offers premium workspaces, including managed private offices and coworking spaces. As the first of its kind in India, Innov8 Coworking creates a productive environment that fosters community engagement among diverse individuals such as founders, investors, freelancers, and creators. The company currently operates multiple centers across major cities in India, including Delhi, Noida, Gurgaon, Mumbai, Bangalore, and Chandigarh. Innov8 Coworking provides essential amenities such as high-speed internet, meeting and conference rooms, and complimentary beverages, all aimed at facilitating collaboration and idea sharing among startup businesses.

Mentat

Seed Round in 2016
Mentat is a company that offers a job application platform designed to streamline the job search process. Utilizing machine learning technology, the platform assists users by rewriting their resumes and generating customized cover letters tailored to specific job applications. Additionally, Mentat provides a service that allows users to apply for jobs on their behalf, simplifying the job-seeking experience. The company's aim is to create a more efficient and effective pathway for individuals to secure better employment opportunities.

Proxy

Seed Round in 2016
Proxy is a technology company that specializes in privacy-first, human-centric identity solutions. Founded in 2016 and based in San Francisco, Proxy develops smartphone-enabled digital identity systems that allow users to authenticate and interact with various devices seamlessly. Its primary offerings include Proxy ID, Proxy Health, and Proxy Access, along with advanced hardware designed to facilitate secure and contactless access. Proxy's mission is to empower individuals with a unique identity signal that they own and control, functioning similarly to a universal single-sign-on for the physical world. This technology is utilized by prominent enterprises like Vornado and Cloudflare to provide employees and visitors with frictionless access to secure areas, enhancing personalized experiences in workplace environments. The company's founders, CEO Denis Mars and CTO Simon Ratner, are committed to ensuring that technology serves to improve human experiences rather than complicate them. Proxy's innovative approach has earned it recognition in several prestigious rankings, highlighting its impact on the future of identity management and access solutions.

Simbi.com

Seed Round in 2016
Simbi, Inc. operates an online platform that facilitates the exchange of services among its members through a unique system of internal credits, rather than traditional monetary transactions. Founded in 2015 and based in San Francisco, the platform allows freelancers and independent workers to convert their unbooked hours into valuable services and experiences. Members can share a wide range of skills and talents, including those of wellness professionals, designers, photographers, and business consultants, among others. Simbi aims to foster community development by promoting volunteerism, mutual aid, and education, thus supporting small-scale entrepreneurs and enhancing economic participation. With its innovative approach, Simbi contributes to the growth of a talent-exchanging network that benefits both individual members and the broader community.
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