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Leuko Labs, Inc., established in 2017 and headquartered in Boston, Massachusetts, specializes in the development of healthcare equipment. The company's primary product, PointCheck, is a non-invasive device designed to monitor and count white blood cells. This innovative technology allows for more frequent testing of immunosuppressed patients, such as those undergoing chemotherapy, enhancing their quality of life and clinical outcomes. The device is particularly beneficial as it eliminates the need for invasive blood draws and laboratory infrastructure, making it more accessible and convenient for patients.

VistaPath Biosystems, founded in 2017 and based in Cambridge, Massachusetts, specializes in developing an automated tissue grossing platform designed to streamline the inspection, description, inking, and measurement of tissues processed for diagnosis. The company's flagship product, VistaPath Sentinel, automates the process of locating, measuring, and imaging tissue as it is placed into a cassette. This platform generates gross reports automatically using the laboratory’s template and provides detailed reports that include gross descriptions, patient and clinician information, and images of containers, labels, and cassettes. By eliminating mix-ups and errors, VistaPath Biosystems' technology enhances the efficiency and accuracy of pathology workflows.

Smack Innovations wants to reduce the number of accidents and deaths due to distracted driving. Specifically, we've developed a way to safely control your smart phone while driving any motor vehicle. SafeConnect is an aftermarket product that a driver can clamp onto any size steering wheel in seconds. Using SafeConnect, a driver can safely control apps and features of his iPhone or Android phone. While always keeping hands on the wheel, eyes focused on the road, and phone in his pocket, the driver can push buttons on SafeConnect to dictate text messages, make phone calls, check the local weather, check sports scores, play music, find the cheapest gas station nearby, get directions that avoid traffic, and much more. Any app on the user’s phone is potentially compatible. Machina research reports automotive mobile connectivity is currently a $22B market growing to $51B by 2018 and $422B by 2022. By 2022, 1.8 billion automotive connections are predicted (700 million connected cars and 1.1 billion aftermarket devices). This is a large and rapidly growing market and we have a solution that is safer and less expensive than any other solution on the market. We have patents, working prototypes, a reputable factory willing to mass produce at low cost, and will soon be seeking our first investment - stay tuned!

Lovebox is a company that specializes in creating emotional connections through innovative technology. Their flagship product, LoveBox, serves as a dedicated channel for exchanging messages between loved ones. The device notifies users with a physical cue—a shaking heart—when they receive a message from their designated partner via the accompanying mobile app. This unique blend of digital interaction and tangible feedback allows individuals to send photos, love notes, drawings, or stickers, enhancing traditional communication with personalized expressions of affection.

Spoiler Alert is a Boston-based software company that provides an inventory liquidation platform specifically designed for perishable consumer packaged goods (CPG) brands. The company operates primarily at the manufacturing plant or distribution center level, enabling food and beverage brands to effectively manage their excess and slow-moving inventory. Spoiler Alert's platform allows these brands to digitize their liquidation processes within a private network of discount retailers and nonprofit organizations. By focusing on maximizing value recovery and enhancing customer relationships, the company aims to streamline the typically manual sales processes faced by supply chain managers. Founded by MIT alumni, Spoiler Alert collaborates with prominent brands, including Campbell's, Danone, HelloFresh, and Kraft Heinz, while also working to support a network of discount channels dedicated to improving food access and reducing food waste.

Tekuma is an incubator for future city innovation. At the intersection of design, technology and real estate, we empower people to solve complex challenges for cities and improve the quality of life. One of the firm's recent milestones includes a partnership with MIT professor Dennis Frenchman in forming Tekuma Frenchman Urban Design LLC, an award-winning international urban design office. Tekuma was founded in 2015 as an art curation company. Over the years, it re-positioned itself on the path of making the future cities. Tekuma is headquartered in Cambridge MA, with branches in Washington DC, Dubai, Chengdu and Beijing.

Lexumo, Inc. is a technology company based in Cambridge, Massachusetts, that offers a cloud-based platform designed to identify and remediate security vulnerabilities in embedded software, enterprise applications, and cloud products. Founded in 2015, Lexumo's platform automatically discovers open-source software within clients' products and scans for known vulnerabilities, providing timely patches and continuous monitoring throughout the software lifecycle. By leveraging big data analytics and advanced software analysis techniques, Lexumo enables organizations to detect vulnerabilities before they escalate into critical issues. The platform offers instant alerts for emerging threats and facilitates the back-porting of patches when direct upgrades are not feasible, thereby assisting developers in maintaining the security and integrity of their software systems.

Cake LLC is a Boston-based company that offers guidance, planning, and consulting services related to end-of-life preferences through its application. This platform allows users to create a secure online document detailing their instructions for various aspects of mortality, including healthcare, funerals, financial, and legal matters. Cake serves as a comprehensive resource, featuring over 1,400 articles and interactive planning tools designed to assist individuals in navigating the complexities of end-of-life decisions. With a monthly reach of over 1.5 million unique visitors, Cake collaborates with various organizations in the healthcare and financial sectors, providing essential support for users looking to curate their digital legacy and make meaningful choices regarding their mortality.

Aquanis, Inc. is a company focused on enhancing the aerodynamic performance of wind turbines to reduce the cost of wind energy. Founded in 2016 and based in East Greenwich, Rhode Island, Aquanis develops innovative electrical devices known as blade-mounted plasma actuators. These actuators are designed to counter unsteady aerodynamic forces, which not only improve the efficiency of wind turbines but also extend their service life. By enabling the design of larger and more efficient turbines, Aquanis aims to contribute significantly to the advancement of renewable energy technologies.

Founded in 2014, TVision is a New York-based company with offices in Boston and Tokyo. It specializes in audience measurement for television and cable viewing, providing second-by-second, person-level data on viewer engagement, including who watches what and how much attention they pay to both linear and streaming content. This data empowers advertisers, agencies, networks, and other stakeholders to make informed media decisions.

Jolt Athletics Inc. is a company that specializes in designing and manufacturing sensors to monitor head impacts in sports in real-time. Founded in 2015 and headquartered in Saint Louis, Missouri, Jolt's technology provides athletes, parents, and coaches with live data and alerts streamed to connected smartphones. The company's mission is to enhance athlete safety and performance by offering innovative technology solutions that allow for smarter training and timely decision-making.

Real Food Solutions is launching a line of food products for everyday discomforts like nausea and heartburn. Their 1st product, Anchor Bar, is a nutrition bar that prevents and relieves nausea including motion sickness and morning sickness. The patent-pending bar was formulated by a Harvard-MD based on scientific research that links protein, ginger, and vitamins to nausea relief. Anchor Bar is a practical solution for nausea – healthy, no side-effects, convenient, and easy to eat. It’s just food.

Embr Labs Inc. is a thermal wellness technology company based in Somerville, Massachusetts, that specializes in developing and selling wearable devices designed to adjust body temperature for enhanced comfort. Originally founded as Wristify Inc. in 2014, the company rebranded in 2015. Embr Labs leverages patented technology to utilize thermal sensations as a means to influence the autonomic nervous system, aiding individuals in managing conditions such as hot flashes, sleep disturbances, and anxiety. The company's innovative approach combines thermal stimulation with digital interventions through a mobile app and cloud infrastructure, creating a comprehensive platform for users. With tens of thousands of customers across 170 countries, Embr Labs has recorded over 100 million minutes of thermal interventions. The technology was conceived by its founders while they were engineering students at MIT, and the company has received significant backing from various investors and grants.

3DEO is commercializing 3D imaging technology that was developed and demonstrated at MIT Lincoln Laboratory over the past 15 years for DoD applications. These airborne 3D mapping systems are field-proven in multiple DoD theatres. They achieve 10x faster collection rates, and therefore 10x lower costs, compared to competing technologies.

Building Envelope Materials specializes in creating innovative solutions to enhance the energy efficiency of existing buildings. Founded in 2014, the company initially received a grant from the Massachusetts Clean Energy Center to develop a method for injecting closed-cell polyurethane foam into under-insulated wall cavities. This technology has been refined through further funding from various organizations, enabling the company to significantly increase insulation values in typical fiberglass-filled walls, from R10 to R23, resulting in a reduction of energy usage by 25% or more. Their pinhole insulation technique allows for insulation installation through a small, easily repaired opening, completing the process for an entire home in just one day. The company is expanding its offerings to include insulation solutions for cathedral ceilings, dormer roofs, and flat roofs, while also working on safer alternatives to traditional spray foam for new construction applications. By fully implementing their pinhole insulation across all cavities, Building Envelope Materials aims to double or triple the energy savings compared to conventional weatherization methods.

Accion Systems Inc. is a Boston-based company that manufactures advanced satellite propulsion systems for the space industry. Founded in 2014, the company specializes in in-space propulsion technologies, particularly its proprietary Tiled Ionic Liquid Electrospray (TILE) system. This innovative technology provides efficient and scalable electric propulsion solutions suitable for a variety of satellite applications, including attitude control, collision avoidance, orbit adjustments, and deorbiting. Accion Systems offers a range of products, including MIN-0 and MAX-1 electric propulsion systems for CubeSats and small satellites, as well as the TILE system for larger spacecraft. Through its cutting-edge propulsion technologies, Accion Systems aims to enhance the capabilities and operational efficiency of satellites in orbit.

Zombait is an innovative manufacturer specializing in robotic fishing lures designed to enhance the fishing experience by revitalizing dead bait. The company's unique product transforms lifeless fish into realistic, injured swimmers, effectively attracting more prey. Zombait's lures are both retrievable and reusable, featuring a long battery life and a corrosion-resistant outer casing, making them suitable for use at depths of up to two hundred feet. By integrating this technology, Zombait allows fishermen to save time and money while improving their chances of a successful catch, thereby revolutionizing traditional fishing practices.

Avalanche Energy is a startup focused on developing compact fusion reactors for diverse applications such as distributed energy, mobility, space propulsion, and power generation. Its innovative platform enables self-sustaining fusion chain reactions, offering high energy density with safety and minimal radioactive waste. The company's modular reactor design allows for stacking to meet varying power demands, contributing to a cleaner, decarbonized planet while facilitating rapid development through iterative testing cycles.

Toymail, established in 2013 and headquartered in New York, specializes in creating safe, screen-free, plush toy-based communication devices for children. These toys, connected to a mobile audio application, allow kids to send and receive voice messages to and from family and friends, fostering connections and promoting verbal communication. The company's products are sold online and are designed to entertain, educate, and connect children with their loved ones.

Silverthread is a company founded in 2013 by experts in finance, technology management, software engineering, and systems engineering. Drawing on over 15 years of research from MIT and Harvard Business School, Silverthread specializes in measuring software design quality and its significant business and financial implications. The company's primary focus is on developing visualization and analytic tools that assist organizations in navigating the complexities of large-scale software systems. By providing consulting services, Silverthread aims to enhance the cost of ownership, minimize cyber risks, and help clients manage intricate software portfolios. Their tools enable clients to align software health with broader business performance objectives, thereby improving overall operational efficiency.

Bevi develops bottle-less water dispensers for offices and commercial spaces that dispense beverages made from filtered tap water with natural flavors, including real fruit essences. The systems allow users to customize drinks and view nutrition information, while the company emphasizes tracking environmental impact and reducing waste from bottled beverages. The technology is designed to run on the municipal water supply, aiming to transform beverage delivery by offering eco-friendly, healthy hydration options on site.

Jisto Inc. is a Boston-based company founded in 2013 that specializes in cloud-computing solutions for enterprises. The company provides a platform designed to help organizations optimize their computing resources by enabling them to run additional applications using stranded server capacity without compromising the performance of core applications. Jisto's services include enterprise data centers, private clouds, public clouds, and hybrid clouds, catering to various sectors such as financial services, pharmaceuticals, life sciences, research, e-commerce, government, and oil and gas. By transforming idle computational resources into a powerful cloud platform, Jisto allows businesses to maximize the value derived from their computing capabilities.

Giant Otter Technologies, Inc. is a developer of conversational artificial intelligence solutions tailored for the video game industry. Founded in 2013 and based in Somerville, Massachusetts, the company specializes in creating AI-enabled chatbots that facilitate automated discussions using existing call recordings and chat transcripts. Their platform is designed to maintain coherent dialogues and provide explanations for its decisions, enhancing user interactions through data generation and conversation modeling. Additionally, Giant Otter Technologies offers services for bot testing and optimization, aiming to improve the effectiveness of communication by analyzing sentence structure and behavioral skills. As of the end of 2018, the company operates as a subsidiary of Drift.com, Inc.

i-Trek is a non-profit organization that has taken an innovative approach to helping increase the number of underserved and underrepresented STEM students

Kaymbu Inc. is a technology company that provides a cloud-based documentation and media management solution tailored for early education centers. Founded in 2012 and based in Cambridge, Massachusetts, Kaymbu enables teachers to document classroom activities through an iPad-based application, allowing for secure communication with families. The platform facilitates the capturing of photos and videos of significant classroom events, fostering stronger connections between home and school. Additionally, it offers features that allow teachers and administrators to access content via web or mobile devices, add contextual notes, and align documentation with various assessment frameworks or accreditation criteria. Kaymbu's tools are designed to enhance engagement and visibility in the learning process, ultimately strengthening school communities.

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Ajua operates as a social commerce platform designed specifically for small and medium enterprises (SMEs) to facilitate customer acquisition and business growth. The company provides an end-to-end platform that enables businesses to create a free online profile, utilize targeted advertising on social media platforms, and accept both offline and online payments securely, without requiring personal banking information. By offering real-time mobile survey capabilities and enabling direct communication between businesses and their customers, Ajua enhances customer engagement and feedback collection. With over 100,000 businesses on its network, Ajua empowers SMEs to strengthen their market presence and improve customer service, ultimately driving decision-making and increasing revenue.

Ecovent is a Boston-based company that specializes in providing an innovative wireless system for controlling room temperature in homes. Founded in 2013, it offers a solution to the inefficiencies of traditional heating and cooling systems, which typically rely on a single thermostat. Ecovent's technology includes wireless vents and sensors that allow users to achieve room-by-room temperature control, ensuring comfort while reducing energy waste. Homeowners can adjust the temperature, open or close vents, and access climate data through a mobile app, tablet, or web interface. This user-friendly system can be installed quickly and easily without the need for specialized tools or invasive construction, making it a practical choice for the over 200 million Americans with forced-air heating and cooling systems.

Street Diligence is a developer of a due diligence and negotiation platform designed to assist investment professionals in analyzing and understanding fixed income deal documents. The platform offers a workflow tool that enhances the efficiency and accuracy of due diligence on high yield bonds and bank loans. It features advanced analytics that provide unique insights into covenant constraints across the capital structure and corporate hierarchy. Additionally, Street Diligence incorporates composite and redline functionality, consolidating all amendments and supplements into a single master document. Its side-by-side comparison tools facilitate trend identification and issue-spotting, enabling clients to streamline the due diligence process and generate more informed investment ideas.

Zepteon, established in 2012 and headquartered in Boston, Massachusetts, specializes in developing chromatography resins tailored for separating non-fucosylated antibodies. These tools enhance the potency of therapeutic antibodies against diseases like cancer and enable rapid analysis of bioreactor conditions. Zepteon's technology supports the preparation of biosimilar antibody filings, potentially increasing regulatory success and accelerating market entry. The company was founded by Austin W. Boesch and Glen R. Bolton.

Bounce Imaging, Inc. is a manufacturer of tactical throwable cameras equipped with multiple lenses and sensors, designed primarily for police and fire responders. The company specializes in developing omnidirectional cameras and sensor technology that allows first responders to safely monitor hazardous environments from a distance, enhancing their operational safety. Founded in 2012 and headquartered in Buffalo, New York, Bounce Imaging provides a variety of supportive accessories such as pole attachments, tethers, car chargers, headsets, wrist straps, and magnetic mounts. In addition to its hardware offerings, the company also delivers cloud services, including technical consulting, design and implementation support, and troubleshooting assistance for imaging and processing hardware. Bounce Imaging's innovative solutions enable users to capture real-time videos and sensor data consistently, even in challenging conditions, making it a valuable asset in the defense and first response sectors.

Avatech Solutions proviservices fordes tools for snow professionals. They offer servicesfor  safety information, powered by connected hardware and software.

Akselos is a technology company that develops Integra, a cloud-based engineering simulation platform and digital twin for asset-centric industries. The platform enables engineers to build high-resolution, component-based models of large systems and run parameterized simulations that cover geometric and physical properties, loads, and boundary conditions. It supports hydrodynamic analysis of floating assets and structural assessment of fixed offshore installations, as well as analysis of composites used in wind blades, pressure vessels, pipelines, and rotating machines. Designed for design, virtual prototyping, and real-time monitoring, Integra leverages fast, patented algorithms that can model large-scale assets on portable hardware. The company's vision emphasizes preventative maintenance and reduced unplanned downtime through real-time asset condition and future-state insights, often described as a digital twin with sensors and big data analytics. Akselos was founded in 2011 in Lausanne, with a Cambridge, Massachusetts office and operations in Europe, the USA, and Southeast Asia.

Merrimack Analysis Group (MAG) helps people understand and manage their digital footprint. MAG delivers seminars to student groups, parent groups, senior citizens' groups, and industry groups on topics related to online identity. MAG also performs consulting work for organizations seeking to develop a comprehensive, effective online strategy, as well as niche Online Reputation Management services. In addition, MAG is developing the Social media Collection, Reporting, Analysis, and Profile Evaluation (SCRAPE) Utility, a cloud-based collaborative program that combines subjective inputs with a proprietary algorithm to make assessments about specifically-queried indicators. MAG was founded by two Massachusetts Army National Guard veterans who saw the operational security blunders created by social media mishaps in Afghanistan; afterwards, they realized that the same sorts of problems were occurring every day in the civilian world, as our society's transition into online-all-the-time has greatly outstripped its grasp of what this change means.

Atlas5D, Inc. is a technology company dedicated to improving the quality of life for individuals with reduced mobility. Founded in 2011 and based in Cambridge, Massachusetts, the company specializes in developing and manufacturing advanced sensors that assess brain, neuromuscular, and cardiovascular conditions. Its flagship product, Echo5D, is a passive ambient sensor that unobtrusively measures human movement and behavior around the clock, without the need for wearable devices. This innovative approach allows for continuous tracking of patient ambulation and dexterity in a home environment, providing valuable insights to caregivers and healthcare professionals. Atlas5D serves diverse sectors including biotechnology, pharmaceuticals, insurance, government, and healthcare, aiming to empower patients with actionable data to monitor their health and maintain independence. The company's founders possess strong academic and professional backgrounds, notably from MIT and Harvard Medical School, and Atlas5D has been recognized as an alumnus of prestigious programs such as MassChallenge and TechStars.

Scripted, Inc. operates an online marketplace that connects businesses with freelance writers across various content types, including blogs, articles, social media posts, and more. The platform allows companies to hire professional writers who are vetted by their areas of expertise, ensuring high-quality content tailored to the needs of small businesses, agencies, startups, and larger enterprises. Scripted's offerings encompass a wide range of subjects, such as technology, healthcare, lifestyle, and marketing, among others. Founded in 2006 and headquartered in San Francisco, California, Scripted aims to enhance brand awareness and improve content quality for its clients.

Takachar is a company focused on transforming agricultural waste into valuable products, particularly eco-friendly cooking fuel. Operating primarily in Kenya, it has developed low-cost technologies that enable the conversion of unmanaged agricultural residues into charcoal, a non-toxic and affordable energy source for low-income households. Over the past three years, Takachar has established or assisted seven locally run waste-to-charcoal enterprises, some of which have achieved operational profitability. The company has successfully created approximately 100 jobs and sold 50 tons of its eco-char product. By utilizing oxygen-lean torrefaction reactors, Takachar helps farmers reduce waste through recycling, allowing them to generate additional income while preventing open burning of agricultural residues. The company aims to demonstrate the financial sustainability of these enterprises as a foundation for expanding its franchise network in the future.

BioBuilder put current synthetic biology research into the hands of teachers and students. By converting exciting and ongoing research questions into teachable modules, they hope to increase interest, engagement and understanding of science and engineering. The digital and hands-on educational resources they provide inspire students to address the world’s persistent challenges by reprogramming living cells. Their professional development workshops reconnect science teachers with their love of teaching.

GelSight is a sensor technology company that develops advanced surface measurement solutions, including a benchtop GelSight scanner that captures the surface geometry of a wide range of materials. Its technology can visualize three-dimensional topography and provide micron-level dimensional measurements by digitizing tactile sensing on an elastomeric interface, enabling detailed measurements across four orders of magnitude. The company serves aerospace, electronics, universities, research institutions, and forensics applications, with prototypes and tools designed to reveal surface features invisible to the naked eye. Based in Waltham, Massachusetts, GelSight focuses on flexible metrology solutions for quality control, testing, and research, helping clients obtain reliable, high-resolution surface data for design, inspection, and material studies.

enEvolv, Inc. is a biotechnology company based in Boston, Massachusetts, that specializes in engineering and licensing microorganisms such as bacteria, yeast, and algae for diverse applications across industries including specialty chemicals, food, energy, personal care, and pharmaceuticals. Established in 2011, the company focuses on developing cost-effective and sustainable solutions to meet the growing global demand for critical resources driven by population growth and increased economic prosperity. enEvolv collaborates with various organizations to create novel microorganisms and enhance existing strains to boost production yields and improve product quality. Utilizing a proprietary genome engineering platform based on advanced techniques developed at Harvard, enEvolv accelerates microbial evolution to enable precise genomic edits, offering significant advantages in speed, cost, and engineering capabilities. As of March 2020, enEvolv operates as a subsidiary of Zymergen, Inc.

Tinfoil Security, Inc. is a cybersecurity company specializing in security-as-a-service for websites. Established in 2011 and based in Palo Alto, California, Tinfoil Security focuses on identifying and mitigating common vulnerabilities through automated scanning techniques. The company mimics external hackers by probing various access points on a website to detect weaknesses, particularly those listed in the OWASP top ten, which represents the most common security flaws. Tinfoil Security utilizes a proprietary scanner that integrates popular open-source tools with custom solutions to deliver precise vulnerability assessments, including specific input requests and their locations. After identifying vulnerabilities, the company provides tailored remediation strategies to help developers secure their websites effectively. As of January 2020, Tinfoil Security operates as a subsidiary of Synopsys, Inc.

Luminoso Technologies, Inc., established in 2010 and headquartered in Boston, Massachusetts, specializes in AI-driven text analytics and experience management solutions. The company's platform leverages artificial intelligence, natural language processing, and machine learning to derive insights from unstructured data, such as customer and employee feedback, product reviews, and open-ended survey responses. Luminoso empowers businesses to understand sentiment, make data-driven decisions, and enhance both customer and employee experiences. Its solutions are trusted by industry leaders and are designed to transform complex feedback into actionable strategies, driving growth and innovation.

CoolChip Technologies Inc. is a specialized provider of thermal management solutions, focusing on Kinetic Cooling technology to enhance the cooling of electronic devices. Founded by MIT engineers in 2010 and based in Somerville, Massachusetts, the company develops high-performance and low-profile coolers tailored for high-performance computing servers, medical devices, data centers, and consumer electronics. CoolChip's innovative cooling systems enable devices such as phones, tablets, and laptops to efficiently dissipate heat with minimal power consumption, improving thermal performance while maintaining compact form factors and low noise levels. The company holds a significant portfolio of intellectual property, positioning it as a leader in transforming the electronics cooling industry and allowing manufacturers to create next-generation products.

Kiinde LLC, established in 2011 and headquartered in Indian Harbour Beach, Florida, specializes in developing, manufacturing, and distributing innovative infant and child care products. The company's portfolio includes pumping, storing, and feeding solutions for breast milk, as well as warming systems and toddler feeding products. Kiinde aims to simplify daily tasks for busy parents by offering products that enhance safety, convenience, and the bond between parents and children.

Neumitra, Inc. is a Boston-based company that specializes in the development of embedded biomodules and mobile application software designed to continuously monitor the autonomic nervous system in real-time. Founded in 2010, Neumitra focuses on creating connected technologies that address the effects of stress on brain health and overall performance. The company's wearable devices track body stress levels and provide alerts through a mobile application, prompting users to take necessary breaks and manage their stress effectively. By linking contextual data, such as events and activities, Neumitra enables individuals to gain insights into their stress patterns and improve their well-being.

Arcbazar.com, Inc. operates an innovative online platform that facilitates design competitions, connecting clients with a diverse pool of designers and contractors. Founded in 2010 and based in Boston, Massachusetts, the company allows clients to initiate competitions for various architectural projects, including remodeling, interiors, landscaping, and commercial developments. Clients can describe their projects, upload relevant images, and set parameters such as award amounts and timelines. Designers then submit their concepts, enabling clients to receive multiple high-quality design solutions at a competitive cost. Arcbazar.com serves homeowners and businesses globally, providing a unique avenue for young designers to showcase their talents while offering clients accessible and creative design options.

Altaeros Energies, Inc. is a company specializing in the development and supply of airborne wind turbines designed to generate renewable energy. Founded in 2010 and headquartered in Somerville, Massachusetts, Altaeros combines advanced aerospace and wind turbine technologies to harness high-altitude winds, which are a largely untapped source of renewable energy. Its buoyant airborne turbines serve a variety of sectors, including rural and island communities, agriculture, mining, oil and gas, and emergency response, among others. The company focuses on providing low-cost and abundant renewable energy solutions to meet diverse energy needs across challenging environments. Altaeros Energies has garnered support for its technology development from multiple funding sources, including government agencies and energy organizations.

FINsix develops advanced power electronic systems, specializing in high-frequency power conversion technology. Its flagship product, the Dart adapter, is a highly miniaturized and efficient charging solution for laptops and USB devices. The company holds over 20 patents and operates from Menlo Park, California.

Affectiva, Inc. is a Boston-based company that specializes in emotion-sensing artificial intelligence software. Founded in 2009 as a spin-off from the MIT Media Lab, Affectiva has established itself as a pioneer in the Emotion AI sector. The company develops advanced technology that utilizes deep learning, computer vision, and speech science to analyze subtle facial and vocal expressions, enabling the detection of nuanced human emotions and cognitive states. Its offerings include a software development kit, a cloud-based API, and in-lab biometric solutions that assist brands, advertisers, and market researchers in understanding consumer engagement with digital content. Affectiva's technology is widely adopted across various industries, including advertising, automotive, social robotics, and healthcare. It serves a broad clientele, including 25 percent of the Fortune Global 500 companies, helping them enhance user interactions and improve the effectiveness of their advertising and communication strategies.

Skulpt was founded in 2009 by Dr. Seward Rutkove, Neurology Professor of Harvard Medical School, and Dr. Jose Bohorquez, Electrical Engineering PhD from MIT. The company develops hardware and software to help athletes and fitness enthusiasts understand their body composition and give them the intelligence to help optimize their training and reach their peak performance. The patented technology, Composition Myography (CM), measures muscle quality and fat content of each major muscle group, giving an unprecedented level of insight into an athlete's body. The Skulpt Muscle Scanner is the world's first and only handheld consumer device that measures individual muscle quality (MQ) and total body fat percentage. The Skulpt app delivers training programs tailored to the unique physique of each user, providing targeted training for optimal results. Initially a medical company, Skulpt has been awarded numerous grants from the National Science Foundation and National Institute of Health to develop CM and validate it through various clinical research trials. Composition Myography has been adopted by dozens of US hospitals and pharmaceutical companies to track the progression of patients with neuromuscular disorders. In 2013, Skulpt began to develop consumer products based on CM technology. Skulpt’s first consumer product, the Aim, was the first-ever electronic to measure muscle quality and the fat content of individual body areas. In March 2016, the company launched the next generation of the Aim, the Chisel Muscle Scanner and an accompanying iOS and Android app.

Sifteo is a San Francisco-based startup that develops an innovative interactive gaming system known as Sifteo cubes. These tactile, cookie-sized devices feature full-color graphics and advanced motion-sensing technology, allowing users to engage in hands-on gameplay by shaking, flipping, tilting, and pressing the cubes. The system promotes a new form of human-computer interaction, blending traditional play patterns with modern interactive technology. Sifteo also serves as a publisher for games exclusive to its platform and actively encourages development through game jams and a freely available software development kit. The company was founded by Dave Merrill and Jeevan Kalanithi, who originally conceptualized the idea at the MIT Media Lab, inspired by the notion of manipulating digital data like physical LEGO blocks. Sifteo's game library caters to a wide audience, offering challenging experiences for adults, educational puzzles for children, and family-friendly games, all embodying the principles of Intelligent Play.

BenchFly is a science video production platform that enables researchers and organizations to communicate scientific information through video. It offers open access and private solutions for laboratories and companies worldwide.

Dacuda is a computer vision company based in Zurich, Switzerland, with additional locations in Palo Alto, California, and Shanghai, China. It specializes in real-time 2D and 3D algorithms that enhance camera capabilities, positioning itself as a pioneer in software 3D camera technology. Dacuda aims to simplify 3D content creation, making it accessible to consumers through app-based scanning solutions. Its technology enables a range of applications, including enhanced user experiences for Augmented and Virtual Reality headsets. Additionally, Dacuda’s innovations include low-cost, real-time image processing that facilitates high-quality scans, effective text recognition, and the conversion of printed text or tables into editable digital formats, thereby streamlining data entry and content sharing. The company has received several prestigious awards for its contributions to technology and innovation.

Ksplice is a provider of Linux update software, specializing in security patches for kernel-level vulnerabilities without requiring system reboots. Their primary product, Ksplice Uptrack, is available free of charge to Oracle Linux customers with Premier support subscriptions and also offered gratis for personal use on Ubuntu Desktop and Fedora.

Locately is a company that specializes in Location Analytics, utilizing advanced software to analyze semi-continuous GPS data from mobile phones. Its services, available in the US and Canada, focus on providing shopper insights by replacing traditional in-person methods of data collection with a modern big data solution. By mining location data, Locately helps clients gain a deeper understanding of consumer behavior and shopping patterns, ultimately enabling them to enhance their sales strategies effectively.

Fire Hose Games is a video game-developing studio company that provides console video games. It is a video game start-up harnessing the power of the sun to make video games.

Clockworks Analytics specializes in automated diagnostics and building performance management software tailored for facility managers, engineers, and service providers. Its flagship platform, Clockworks, is utilized globally to enhance energy efficiency, facilitate proactive maintenance, and improve overall building operations. The software equips users with tools to identify and prioritize energy savings opportunities while providing access to building data and diagnostics in real-time. This capability supports the optimization of commissioning processes, LEED projects, and performance-based incentive programs, ultimately contributing to sustained energy savings and more comfortable environments within managed buildings.

Filter Sensing Technologies (FST) is an MIT spin-off established in 2008, focused on advancing high-performance sensor technologies. With over four years of research and development behind it, the company has cultivated a robust patent portfolio that includes numerous applications in the United States and internationally. FST specializes in providing sensor technologies, particularly for diesel emission control, and offers solutions for ceramic filter cleaning services. Through its innovative approach and commitment to quality, FST aims to address critical environmental challenges in the automotive and industrial sectors.

Vitality is a company focused on enhancing medication management for patients and healthcare professionals through innovative technology. It develops internet-connected health and wellness products, particularly the Vitality GlowCaps, which are web service-integrated pill caps designed to improve adherence to medication regimens. These caps use wireless connectivity to monitor when a pill bottle is opened and send alerts to patients or caregivers, helping to ensure timely medication intake. The GlowCaps feature multiple reminder mechanisms, including illumination, melodies, and phone notifications, to assist users in remembering their doses. Additionally, the design includes a button for easy refills, streamlining the medication management process. Through these advancements, Vitality aims to foster better health outcomes by addressing common challenges in medication adherence.

Pixable is a start-up founded in 2009 and headquartered in SoHo, New York City, with roots at MIT. The company provides a free application that allows users to manage and enjoy their online photos by aggregating content from various social networks. Pixable's platform offers a personalized browsing experience, sorting photos and trending stories based on user relevance. With over 6 million users, the application not only helps individuals discover and share engaging content but also features stories curated by a skilled editorial team. In 2012, Pixable was acquired by SingTel as part of its Digital L!fe Group, which aims to enhance digital technologies for its customers. The company has received significant media attention, being featured in prominent publications such as The New York Times and CNN, and has been recognized as one of the coolest companies to work for by Time Out Magazine.

Cogito enhances emotional intelligence in phone professionals via AI-powered behavioral science. Its software analyzes voice signals during calls, providing real-time coaching for agents and measuring customer experience.

Abroad101 is the first and largest study abroad reviews platform, established in 2007 and headquartered in New York City. The company operates an online education portal that promotes global citizenship by enhancing meaningful study abroad experiences. It features a robust evaluation system that allows universities to collect and share program evaluations online, facilitating easy access to information for prospective students and their families. With over 27,000 detailed reviews on various programs worldwide, Abroad101 helps students make informed decisions and sets realistic expectations for their time abroad. Additionally, program providers can leverage the platform to reach a large audience of potential students by advertising their offerings. In 2013, Abroad101 was sold to an investor group, further solidifying its position in the market.

AquaVenture WaterCrafts is poised to have an immense impact on the marine industry.

Founded in 2007, Artaic specializes in designing and fabricating custom tile work for commercial and residential markets. Utilizing computer-aided design software and robotic assembly systems, the company creates innovative mosaics for various industries such as hospitality, retail, and public art.

PurposeEnergy, Inc. specializes in providing consultative services and wastewater management solutions primarily for the food and beverage industry. Established in 2007 and headquartered in Woburn, Massachusetts, the company conducts comprehensive audits of clients' wastewater strategies and offers tailored recommendations for organic waste remediation and technology enhancements. PurposeEnergy develops advanced wastewater systems that convert organic residuals into renewable energy and clean water. This innovative approach helps clients improve production efficiency, reduce costs associated with trucking and off-site waste disposal, lower energy and water expenses, and minimize their carbon footprint.

Shred and Slytech began with a friendship and a shared commitment to enhancing their time in the mountains. And through the years, they’ve remained true to these roots. I first met Carlo in the winter of 2005. When not working as a materials engineer, he raced for fun and tapped his extensive experience with carbon fiber to develop his own ski equipment. As someone who constantly tinkered with his own gear, I was intrigued by Carlo’s work. Consequently, they quickly became friends and began collaborating on prototypes. Soon, some of the best skiers in the world began sporting his shinguards. And within a year of working together, I was able to take these products to the top of the Olympic podium. From this momentum and thirst for innovation, Slytech Protection was born. Immediately, they began turning heads. Yet their vision transcended the race course. I was part of a new generation of skiers who raced but didn’t wish to be defined or constrained by it. They loved hitting the park, slashing pow turns, and hucking cliffs. Like many of my friends, I was just as influenced by freeskiing and snowboarding as I was by racing. Consequently, Carlo and I aimed to embrace and unite all snowsports. At the time, this approach was as unique as it was raw. In the fall of 2006, they debuted Shred Optics. As with Slytech, their plans were simple. They wanted to develop products that looked as good as they performed—and not just on the race course, but also in the park and backcountry. Their inaugural collection consisted of a single goggle frame, available in a healthy dose of neon. Iconic, original, loud—whatever you called them, their goggles were visible from across the valley. About this same time, they also launched the first soft back protector with Slytech, which was soon worn by top freeskiers, snowboarders, and racers. With hustle and grit, they worked to further refine their vision for Shred and Slytech. When not slaving away over R&D inside a garage, Carlo hijacked a corner of his father’s office in Venice, Italy for their global headquarters. Meanwhile, they ran their US operations out of my attic in Park City, enlisting their friends as sales reps. They didn’t have a business plan, but they had plenty of ambition. Today, they have a few more products to their name, but their commitment to innovation is stronger than ever. Whether developing helmets, back protectors, sunglasses, or goggles, they’re pioneering fresh technology and emerging as a market leader—while proudly maintaining their status as underdogs. By blending performance and style, Slytech and Shred help you have fun, stay safe, and push your limits. And ten years in, they’re still building the products of their dreams.

Promethean Power Systems, Inc. specializes in designing and manufacturing refrigeration systems tailored for cold-storage and milk chilling applications, particularly in off-grid and partially electrified regions. Founded in 2007 and headquartered in Somerville, Massachusetts, with an office in Pune, India, the company provides a range of products including milk chillers, cold storage units, solar add-ons, and smart monitoring solutions. Its innovative systems are aimed at dairy processors and individual farmers, helping them to reduce spoilage and enhance the quality of milk collected from rural areas. By enabling the preservation of milk at the village level, Promethean's technology not only lowers transportation costs for processors but also increases farmer incomes. The refrigeration systems are designed to operate on grid power and are equipped with a generator backup, with plans to incorporate thermal battery storage for greater efficiency in the future.

Julianna Rae is an online retail platform specializing in women's apparel, focusing on luxury sleepwear and lingerie. The company offers a diverse selection of clothing and intimate apparel crafted from high-quality silks, cotton, and modal fabrics, catering to the fit and fashion preferences of women. Additionally, Julianna Rae aims to appeal to eco-conscious consumers by providing stylish options that align with sustainable practices.

Nanda Home is focused on developing and manufacturing a collection of useful objects for homes. The company offers Clocky, an alarm clock that keeps moving while beeping until its user gets out of bed; and Tocky, an alarm clock that plays MP3 songs while rolling away. Nanda Home was founded in 2006.

NetBase Solutions, Inc. specializes in social media analytics, providing a comprehensive platform that processes billions of social media posts daily to deliver actionable insights for various business functions, including marketing, research, and customer service. The company’s offerings include the NetBase LIVE Pulse Product Suite, which allows users to monitor brand and campaign performance and competitive movements. Key tools within their platform include real-time monitoring solutions, natural language processing capabilities for understanding social media content, and audience segmentation tools that help brands gain deeper insights into their customers. NetBase's services span multiple areas, such as social TV analytics, campaign tracking, brand analysis, and crisis management, catering to a diverse range of industries from financial services to telecommunications. Founded in 2003 and headquartered in Mountain View, California, NetBase also has offices in London, Paris, and Heidelberg. The company was previously known as Accelovation, Inc. until its rebranding in 2008.

SmartCells, Inc. designs and develops insulin products. It offers SmartInsulin, a self regulating injectable formulation for treating diabetes. The company's polymer-based dosing technology is used for various applications, such as fertility, thyroid, and growth hormone deficiencies; treatments with poor compliance or therapeutic window issues, such as oncology; and drug-device combinations. SmartCells, Inc. was founded in 2003 and is based in Beverly, Massachusetts.

Barrett Technology, LLC, established in 1990 and located in Newton, Massachusetts, specializes in the design and manufacture of advanced robotic manipulators. The company has pioneered technology that enhances flexibility in articulated arms and hands, positioning itself as a leader in this field. Renowned for its innovative solutions, Barrett Technology earned recognition in the Guinness Book of World Records for its advanced manipulator technology. The company offers a high degree of versatility, catering to a wide range of applications across various industries.

Agrivida, Inc. is a biotechnology company specializing in animal health and nutrition through the development of innovative feed additives for poultry, swine, dairy and beef cattle, and aquaculture. Founded in 2003 and based in Four Seasons, Missouri, Agrivida utilizes its proprietary GRAINZYME technology to produce enzymes directly within corn kernels, offering a natural and effective method to enhance animal diets. This platform enables the integration of beneficial enzymes such as phytase and glucanase, which improve nutritional efficiency and reduce the environmental impact of livestock production. Agrivida's solutions aim to promote healthier food production while delivering economic benefits to its clients in the agricultural sector.