Freeflow Ventures

Mitico specializes in advanced carbon capture technology. Utilizing its patented granulated metal carbonate sorption process, developed at Caltech, Mitico removes over 95% of CO2 emissions from post-combustion sources such as gas-fired power plants and waste-to-energy facilities. This enables cost-effective carbon capture, utilization, and storage (CCUS) services.

MIIST Therapeutics focuses on advancing pulmonary drug delivery systems and digital platforms to improve inhaled drug therapies. The company is developing innovative technology aimed at facilitating smoking cessation and addressing the health risks associated with tobacco use. By creating inhaler technology that targets the deepest areas of the lungs, MIIST enables rapid absorption of medications. This approach aims to enhance the effectiveness of inhaled treatments for various health conditions, starting with smoking addiction, and ultimately seeks to reduce the significant health burdens related to tobacco consumption.

Aralez Bio is a biotechnology company specializing in the sustainable production of noncanonical amino acids (ncAAs), also known as unusual or unnatural amino acids. The company has developed a novel enzymatic method that allows for the synthesis of over 100 ncAAs with perfect enantiopurity in a single step, producing water as the sole byproduct. This proprietary approach provides clients in various sectors, including pharmaceuticals, agriculture, and functional materials, with access to essential amino acids needed for innovation and development in their respective fields.

Persperity Health is a technology company specializing in women's health. It develops a non-invasive, real-time hormone tracking platform, combining biosensors and AI-driven data analytics. This platform empowers women with personalized insights into their hormonal health, transforming the management of fertility, menopause, and overall wellness, and enabling them to take control of their hormonal well-being.

Esperto Medical is a medical device company based in Irvine, California, focused on developing advanced wearable diagnostics for both hospital and remote patient monitoring. The company utilizes innovative resonance sonomanometry technology, which employs acoustic stimulation to provide continuous and noninvasive blood pressure measurements without the need for calibration. By enabling round-the-clock monitoring of vital signs, Esperto Medical’s devices aim to enhance accessibility to medical care through automation, allowing patients to effectively manage their health from home or within clinical settings.

Calicat is a clean-energy company developing a proprietary electrocatalyst discovery process for electrolyser. The company electrocatalyst discovery is an unprecedented, proprietary, end-to-end ultrahigh throughput AI and data-driven process focused on the discovery of new catalysts for the generation of clean hydrogen and fuel cell power production. The process prepares, characterizes, and quantifies the catalytic activity of millions of compositions per month and then closes the loop with big data analysis and AI to refine/guide the search.

Curry it is a food manufacturing company that offers ready-to-cook curries, pastes, and mixes for vegetarian and non-vegetarian recipes.

Holoclara is an immunotherapy company focused on providing innovative solutions for individuals suffering from autoimmune disorders. The company specializes in delivering nematode-derived molecules known for their therapeutic properties. By identifying and developing these molecules from various worm species, Holoclara aims to create safe, orally available therapeutics that can improve the quality of life for patients. Through its targeted approach, Holoclara seeks to bring relief and promote overall health and well-being for those affected by autoimmune conditions.

StrokeDx is a company that specializes in the development of innovative and portable diagnostic devices aimed at revolutionizing stroke care. Through the use of advanced microsensors and artificial intelligence, StrokeDx's products can quickly detect blood presence in the brain, generating predictive images of stroke locations after scanning. This technology significantly reduces the time to treatment for stroke patients and is designed to be more cost-effective than traditional diagnostic methods. The company employs a dedicated software engineering team focused on creating novel algorithms that enhance the diagnostic accuracy and imaging capabilities of its devices, ultimately improving the triage and diagnosis process for healthcare providers.

Catena Biosciences specializes in biotechnology, offering protein conjugation services for building biological structures and facilitating medical research. Its proprietary technology enables the attachment of proteins with high selectivity, supporting innovation in autoimmune disorders, oncology, and vaccine development.

Tierra Biosciences, established in 2015 and based in San Francisco, specializes in developing cell-free technologies for molecule discovery. Its Next Generation Expression platform combines automation, computation, and high-throughput cell-free expression to express DNA from diverse microbial sources, enabling the production of molecules challenging to create using conventional laboratory methods. The company's protein platform integrates cell-free protein production with artificial intelligence, facilitating rapid, large-scale manufacturing akin to e-commerce simplicity. Formerly known as Synvitrobio, Inc., Tierra Biosciences changed its name in September 2018.

Captura is a direct ocean capture company developing a carbon removal system that extracts carbon dioxide from ocean water to enable scalable, low-cost removal from the atmosphere. It uses electrodialysis technology that captures carbon without generating waste or requiring feedstocks, offering ocean-based removal suitable for carbon credit markets and producers of low-carbon products.

Mitico specializes in advanced carbon capture technology. Utilizing its patented granulated metal carbonate sorption process, developed at Caltech, Mitico removes over 95% of CO2 emissions from post-combustion sources such as gas-fired power plants and waste-to-energy facilities. This enables cost-effective carbon capture, utilization, and storage (CCUS) services.

Continuum Space Systems offers a Unified Mission Management SaaS platform to plan and execute space missions more efficiently. The platform supports planning, simulation, and execution while integrating risk management, real-time decision support, and AI-powered insights. It enables collaboration, reduces uncertainty, and provides an end-to-end framework to manage a mission across its lifecycle from concept to operations for space agencies, contractors, and commercial operators.

Hydrosat is a climate technology company that uses space-based thermal imagery to measure water stress in agriculture, supporting water stewardship, food security, public safety and environmental management. Founded in 2017 and based in Washington, D.C., the company develops irrigation and crop management software that helps governments and other customers preserve water while boosting crop yields. Its software provides field irrigation planning, regional irrigation diagnosis and monitoring, and field production forecasting, delivering field- and regional-level analytics through a web portal, mobile app, and API. Hydrosat aims to enable informed decisions and sustainable practices worldwide, combining satellite data with actionable insights for governments, institutions, and enterprises.

Switch Therapeutics is a biotechnology company founded in 2020 and based in San Francisco, California. The company focuses on revolutionizing RNA interference (RNAi) therapies by developing biomarker-gated genetic medicines. These innovative therapies utilize nucleic acid nanotechnology and RNAi science to target a variety of diseases, particularly those affecting the central nervous system and other systemic conditions with significant unmet medical needs. Switch Therapeutics aims to provide healthcare providers with RNA molecules and therapies that can be activated selectively in specific cells, enhancing the precision of treatments for central nervous system diseases.

Wild Microbes is a pioneering microbial platform focused on producing sustainable chemicals, ingredients, and materials. The company specializes in developing new microbial strains through synthetic biology, which allows for the efficient modification and cultivation of microbes. This innovative approach enables Wild Microbes to create a wide range of products, from plastics to proteins, while significantly reducing costs and accelerating the scaling of sustainable solutions. By leveraging its expertise in microbial engineering, Wild Microbes aims to facilitate the adoption of environmentally friendly practices across various industries.

Founded in 2016, Membrion specializes in manufacturing and commercializing advanced membrane filtration technologies. Its products are designed to filter molecules under diverse conditions, serving applications such as flow batteries, water purification, fuel cells, and pharmaceuticals.

Captura is a direct ocean capture company developing a carbon removal system that extracts carbon dioxide from ocean water to enable scalable, low-cost removal from the atmosphere. It uses electrodialysis technology that captures carbon without generating waste or requiring feedstocks, offering ocean-based removal suitable for carbon credit markets and producers of low-carbon products.

Calicat is a clean-energy company developing a proprietary electrocatalyst discovery process for electrolyser. The company electrocatalyst discovery is an unprecedented, proprietary, end-to-end ultrahigh throughput AI and data-driven process focused on the discovery of new catalysts for the generation of clean hydrogen and fuel cell power production. The process prepares, characterizes, and quantifies the catalytic activity of millions of compositions per month and then closes the loop with big data analysis and AI to refine/guide the search.

Comprehensive health care solutions to bring, nurse, assistant, meds, basic diagnostics to the home along with paneled doctors for virtual consultations and home visits.

Hydrosat is a climate technology company that uses space-based thermal imagery to measure water stress in agriculture, supporting water stewardship, food security, public safety and environmental management. Founded in 2017 and based in Washington, D.C., the company develops irrigation and crop management software that helps governments and other customers preserve water while boosting crop yields. Its software provides field irrigation planning, regional irrigation diagnosis and monitoring, and field production forecasting, delivering field- and regional-level analytics through a web portal, mobile app, and API. Hydrosat aims to enable informed decisions and sustainable practices worldwide, combining satellite data with actionable insights for governments, institutions, and enterprises.

Hydrosat is a climate technology company that uses space-based thermal imagery to measure water stress in agriculture, supporting water stewardship, food security, public safety and environmental management. Founded in 2017 and based in Washington, D.C., the company develops irrigation and crop management software that helps governments and other customers preserve water while boosting crop yields. Its software provides field irrigation planning, regional irrigation diagnosis and monitoring, and field production forecasting, delivering field- and regional-level analytics through a web portal, mobile app, and API. Hydrosat aims to enable informed decisions and sustainable practices worldwide, combining satellite data with actionable insights for governments, institutions, and enterprises.

Appia Bio is a biotechnology company dedicated to the research and development of off-the-shelf allogeneic cell therapies, with a particular focus on engineered allogeneic cell therapies for various medical indications. The company utilizes its proprietary ACUA technology platform to harness the biology of lymphocyte development, integrating chimeric antigen receptor (CAR) and T-cell receptor (TCR) gene engineering. This innovative approach allows Appia Bio to generate CAR-engineered invariant natural killer T (CAR-iNKT) cell subtypes derived from hematopoietic stem cells (HSCs). By maturing and scaling healthy stem cells into invariant T-cell therapies, Appia Bio aims to provide physicians with safe and targeted cancer treatment options, thereby expanding patient access to advanced therapeutic solutions.