Abingworth

Atsena Therapeutics is a clinical-stage gene therapy company dedicated to developing innovative treatments for inherited retinal diseases. The company focuses on therapies for conditions such as X-linked retinoschisis and GUCY2D-associated Leber congenital amaurosis. Utilizing an advanced adeno-associated virus (AAV) technology platform, including a novel spreading capsid, Atsena aims to target specific retinal conditions to prevent blindness resulting from genetic mutations. Their research is centered on providing effective ocular gene therapies that address significant challenges associated with inherited retinal diseases, with the goal of reversing or halting vision loss.

AdvanCell is a clinical-stage radiopharmaceutical company focused on developing innovative cancer therapeutics. The company specializes in alpha-emitting isotopes that are linked to molecules designed to deliver targeted cytotoxic radiation directly to tumors. This approach allows for radiotherapy at the molecular level, addressing significant challenges in targeted alpha therapy, particularly in ensuring a reliable and scalable supply. AdvanCell aims to provide safe and effective treatment options for various forms of cancer, with the goal of establishing its therapies as a standard of care in oncology.

Timberlyne Therapeutics is a biopharmaceutical company focused on developing and commercializing innovative therapies for autoimmune diseases. It leverages its team's expertise in drug development to acquire promising assets targeting unmet medical needs. The company specializes in monoclonal antibodies with enhanced complement-dependent cytotoxicity, specifically targeting CD38, a protein highly expressed in various immune cells. This approach enables rapid and durable responses across a range of autoimmune diseases.

Iambic Therapeutics focuses on accelerating molecular discovery through its innovative quantum molecular simulation engine. By integrating artificial intelligence and automated synthetic development, the company aims to enhance the design of small-molecule therapeutics. This technology significantly improves the accuracy of molecular predictions, providing valuable insights for therapeutic discovery. Iambic Therapeutics is committed to transforming the drug development process, enabling physicians to access more precise molecular data and ultimately improving treatment outcomes.

Q32 Bio Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapies for severe autoimmune and inflammatory diseases. Established in 2017, the company aims to address immune system dysregulation, providing treatment options for conditions that currently have limited or inadequate therapies. Q32 Bio's pipeline includes ADX-914, a human anti-IL-7R antibody designed to re-regulate adaptive immune function, and ADX-097, which demonstrates effective distribution to affected tissues and robust efficacy. With a team of experienced scientists and industry professionals, Q32 Bio is dedicated to restoring healthy immune balance through novel biologic therapies that target critical pathways in both the innate and adaptive immune systems.

Gilead Sciences is a research-based biopharmaceutical company dedicated to discovering, developing, and commercializing innovative medicines to address unmet medical needs. The company's primary focus is on therapies for life-threatening infectious diseases, particularly HIV/AIDS and hepatitis B and C. Gilead's portfolio includes the hepatitis C drug Sovaldi, which emerged from its acquisition of Pharmasset, and is part of established combination treatment regimens. Additionally, Gilead is expanding its presence in oncology through strategic acquisitions, including CAR-T cell therapies such as Yescarta and Tecartus, as well as breast and bladder cancer treatments like Trodelvy. By concentrating on these critical areas, Gilead aims to enhance patient care and outcomes for those with serious health conditions.

Jasper Therapeutics, Inc. is a clinical-stage biotechnology company based in Menlo Park, California, that specializes in developing therapeutic agents for hematopoietic stem cell transplants and gene therapies. Founded in 2018, the company aims to enhance the safety and efficacy of conditioning agents to broaden the application of curative therapies. Jasper's lead product, JSP191, is a humanized monoclonal antibody currently in clinical development, designed to act as a conditioning agent by selectively clearing hematopoietic stem cells from bone marrow in patients undergoing stem cell transplants. The company also utilizes an engineered hematopoietic stem cells platform to address the limitations of transplant grafts, thereby increasing the accessibility of both allogeneic and autologous gene-edited hematopoietic stem cell therapies for a larger patient population.

Ascend Gene & Cell Therapies supports manufacturing and process development projects from design through to clinical and commercial scales. They partner with biotechnology teams to embed scalable manufacturing in their operations from the beginning. They respond to customer inquiries by phone and contact form.

Spruce Biosciences, Inc. is a biopharmaceutical company based in Daly City, California, specializing in the development and commercialization of innovative therapies for rare endocrine disorders. Founded in 2014, the company is primarily focused on its lead product candidate, tildacerfont, which is undergoing clinical trials for adult and pediatric patients with classic congenital adrenal hyperplasia (CAH). Tildacerfont is being developed as a non-steroidal therapy aimed at improving disease management and reducing reliance on steroids for affected patients. Additionally, the company is exploring the use of tildacerfont for females with polycystic ovary syndrome. With a commitment to addressing the unmet medical needs of patients with rare endocrine conditions, Spruce Biosciences aims to enhance the quality of life for those who have been historically underserved by existing treatment options. The company also has a partnership with Eli Lilly and Company to explore further pharmaceutical applications of its compounds.

Pathalys Pharma is a clinical biopharmaceutical company focused on developing innovative therapeutics for late-stage chronic kidney disease, particularly targeting secondary hyperparathyroidism (SHPT). SHPT is a condition characterized by the overactivity of the parathyroid glands, resulting from diseases outside of these glands, leading to excessive production of parathyroid hormone (PTH). The company's lead product, upacicalcet, is a novel calcimimetic designed to improve treatment outcomes for hemodialysis patients by mimicking calcium's effects on tissues through the activation of calcium-sensing receptors found in various human organs. Pathalys aims to address significant unmet medical needs in the management of SHPT, ultimately enhancing the quality of care for patients with end-stage chronic kidney disease.

Cytospire Therapeutics specializes in developing a portfolio of innovative, next-generation immune cell engagers. These are multispecific antibodies designed to enhance and direct the power of key effector cells in the immune system, offering patients more effective treatments compared to existing therapies.

Entact Bio is a biotechnology company that is in the preclinical stages of developing medications to improve protein function. It was founded by a team with deep roots in deubiquitinase (DUB) biochemistry, chemical biology, disease biology, and small-molecule drug development. The company's proprietary EncompassTM platform was designed to create enhancement-targeting chimeric (ENTACTM) medicines. ENTACs take advantage of DUBs' ability to regulate proteins.

Opthea Limited is an Australian biotechnology company specializing in the development of innovative biologic therapies aimed at treating eye diseases. The company’s primary focus is on its lead compound, OPT-302, which inhibits the action of vascular endothelial growth factors VEGF-C and VEGF-D, both of which are implicated in abnormal blood vessel growth and leakage, conditions prevalent in diseases such as wet age-related macular degeneration. Opthea's research and development efforts are supported by a robust intellectual property portfolio that encompasses these key vascular targets, positioning the company to address significant unmet medical needs in the field of ophthalmology.

Launch Therapeutics is a clinical development company dedicated to advancing drug development within the biotechnology and biopharmaceutical sectors. The company partners with various firms to provide expertise in regulatory affairs, medical operations, and clinical operations. By focusing on eliminating inefficiencies in the clinical development process, Launch Therapeutics aims to accelerate the pathway for new therapies to reach the market. Through its comprehensive support services, the company enhances the ability of its partners to successfully navigate the complexities of drug development and regulatory requirements.

Venatorx Pharmaceuticals, Inc. is a pharmaceutical company dedicated to the discovery and development of innovative anti-infective agents aimed at addressing multi-drug-resistant (MDR) bacterial infections and challenging viral infections. Founded in 2010 and headquartered in Malvern, Pennsylvania, the company specializes in creating antibacterial drugs that target resistant pathogens, including those responsible for difficult-to-treat infections such as MRSA, Pseudomonas, and Salmonella. By employing novel chemical approaches, Venatorx develops treatments with selective and potent activity against various bacterial resistance mechanisms, thereby enhancing the therapeutic options available to healthcare professionals and addressing significant unmet medical needs in the field of infectious diseases.

eFFECTOR Therapeutics, Inc. is a clinical-stage biotechnology company based in San Diego, California, that specializes in the development of selective translation regulators for the treatment of cancer and other serious diseases. Founded in 2012, the company is pioneering a new class of oncology drugs known as selective translation regulator inhibitors (STRIs). These drug candidates specifically target the eIF4F complex and its associated kinase, MNK 1/2, which play critical roles in protein synthesis and are linked to prominent cancer signaling pathways such as PI3K-AKT and RAS-MEK. eFFECTOR's products aim to inhibit pathways that drive tumor growth, survival, and immune evasion by regulating the expression of oncoproteins and immunosuppressive proteins. The lead candidate, tomivosertib, is currently being evaluated in a Phase 2b trial for non-small cell lung cancer in combination with pembrolizumab. Additionally, zotatifin, an inhibitor of eIF4A, is undergoing dose-escalation in a Phase 1/2 trial, with further expansion cohorts anticipated. The company also collaborates with Pfizer to advance inhibitors targeting eIF4E.

CymaBay Therapeutics, Inc., established in 1988 and headquartered in Newark, California, is a clinical-stage biopharmaceutical company dedicated to developing therapies for liver diseases and other chronic conditions with significant unmet medical needs. Its primary focus is on seladelpar (MBX-8025), a selective agonist of peroxisome proliferator activated receptor delta, currently in Phase II trials for treating primary biliary cholangitis, sclerosing cholangitis, and nonalcoholic steatohepatitis. Additionally, the company is developing MBX-2982, an orally-active G protein-coupled receptor agonist targeting gut/liver diseases, and CB-001, a preclinical-stage product candidate for treating gut/liver disease using omega-3 fatty acids. CymaBay has partnerships with Janssen Pharmaceuticals and DiaTex for developing therapies for metabolic diseases and gout, respectively.

Glycomine, Inc. is a biotech company based in San Carlos, California, focused on developing nanomedicines for rare genetic disorders, particularly those related to protein and lipid glycosylation. Founded in 2014, the company addresses the significant unmet medical needs of patients suffering from rare diseases, of which approximately 7,000 exist globally, with a majority lacking FDA-approved treatments. Glycomine specializes in creating replacement therapies that combine substrates, enzymes, and proteins with advanced bio-nano materials. These therapeutics are designed to facilitate the targeted delivery of treatment to clinically relevant organs, thereby enhancing the efficacy of care for conditions characterized by metabolic disorders and protein misfolding.

Adaptate Biotherapeutics is a London-based biotherapeutics company founded in 2019 by Adrian Hayday. The company specializes in developing antibody-based therapies aimed at modulating gamma delta T cells in situ. By leveraging innovative technologies, Adaptate focuses on creating immunotherapies that target cancer and autoimmune diseases. Its approach has the potential to significantly influence treatment options for patients with these conditions, providing access to effective and novel therapeutic modalities.

X4 Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, specializing in the discovery and development of innovative therapeutics for primary immune deficiencies and cancer. The company's lead drug candidate, mavorixafor, is an oral small molecule antagonist of the chemokine receptor CXCR4, currently undergoing multiple clinical trials. These include a Phase III trial for patients with warts, hypogammaglobulinemia, infections, and myelokathexis syndrome, as well as Phase Ib and Phase IIa trials focused on severe congenital neutropenia and clear cell renal cell carcinoma, respectively. In addition, X4 Pharmaceuticals is advancing X4P-002, targeting glioblastoma multiforme, and X4P-003 aimed at primary immune deficiencies. The company has also established a license agreement with Abbisko Therapeutics to develop mavorixafor in combination with checkpoint inhibitors for oncology applications. Founded in 2014, X4 Pharmaceuticals was previously known as Arsanis, Inc. before rebranding in March 2019.

Vera Therapeutics, Inc. is a biotechnology company based in South San Francisco, California, founded in 2016 and formerly known as Trucode Gene Repair, Inc. The company focuses on developing innovative biologic therapeutics with the potential to transform treatment for patients suffering from serious immunological diseases and genetic disorders. Its lead product candidate, atacicept, is a fusion protein administered as a subcutaneous injection once weekly, designed to inhibit factors that stimulate the production of autoantibodies associated with autoimmune diseases. Additionally, Vera Therapeutics is utilizing gene-editing technology aimed at addressing conditions such as sickle cell disease and cystic fibrosis, striving to enhance gene detection and regulation for improved patient outcomes.

Atsena Therapeutics is a clinical-stage gene therapy company dedicated to developing innovative treatments for inherited retinal diseases. The company focuses on therapies for conditions such as X-linked retinoschisis and GUCY2D-associated Leber congenital amaurosis. Utilizing an advanced adeno-associated virus (AAV) technology platform, including a novel spreading capsid, Atsena aims to target specific retinal conditions to prevent blindness resulting from genetic mutations. Their research is centered on providing effective ocular gene therapies that address significant challenges associated with inherited retinal diseases, with the goal of reversing or halting vision loss.

Reneo Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company based in San Diego, California, dedicated to developing therapies for patients with rare genetic mitochondrial diseases. These conditions are characterized by deficits in cellular metabolism and energy production, often leading to significant health challenges. The company is focused on creating treatments that improve mitochondrial function, preserve muscle integrity, and enhance the overall quality of life for affected individuals. Its lead product candidate, REN001, is an oral medication designed to modulate genes critical to the production of adenosine triphosphate (ATP), the primary energy source for cellular processes. Founded in 2014, Reneo aims to address the unmet needs of patients suffering from orphan metabolic diseases linked to mitochondrial dysfunction.

Q32 Bio Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapies for severe autoimmune and inflammatory diseases. Established in 2017, the company aims to address immune system dysregulation, providing treatment options for conditions that currently have limited or inadequate therapies. Q32 Bio's pipeline includes ADX-914, a human anti-IL-7R antibody designed to re-regulate adaptive immune function, and ADX-097, which demonstrates effective distribution to affected tissues and robust efficacy. With a team of experienced scientists and industry professionals, Q32 Bio is dedicated to restoring healthy immune balance through novel biologic therapies that target critical pathways in both the innate and adaptive immune systems.

Scorpion Therapeutics, Inc. is a clinical-stage biotechnology company based in Boston, Massachusetts, focused on advancing precision oncology for cancer treatment. Founded in 2020, the company specializes in developing targeted small-molecule drugs that address validated cancer targets, as well as previously undruggable and novel targets. Scorpion Therapeutics utilizes an integrated approach that combines target discovery, medicinal chemistry, and translational medicine to create a diverse pipeline of optimized compounds. By leveraging its precision medicine platform, the company aims to enhance the efficacy of cancer therapies and expand treatment options for patients, ultimately striving to overcome the limitations of existing cancer treatments.

NuCana plc is a UK-based, clinical-stage biopharmaceutical company dedicated to developing innovative cancer treatments. It specializes in transforming widely-used chemotherapy agents into more effective and safer medicines using its proprietary ProTide technology. NuCana's pipeline includes Acelarin, in Phase III trials for biliary tract and metastatic pancreatic cancers, and NUC-3373 & NUC-7738, in Phase I trials for advanced solid tumors. The company collaborates with academic institutions for research and licensing agreements. NuCana was established in 1997 and is headquartered in Edinburgh, with a focus on the U.S. market.

Nido Biosciences, Inc., incorporated in 2018 and based in Boston, Massachusetts, is a clinical-stage company focused on developing precision medicines for severe neurological diseases. The company employs a functional genomics discovery platform utilizing human cell lines to identify novel therapeutic targets for various neuromuscular and neurodegenerative conditions. By leveraging advances in neuroscience and human genetics, Nido Biosciences aims to create precise medications that address the underlying biology of these diseases, ultimately restoring healthy cell function and improving patient outcomes.

Q32 Bio Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapies for severe autoimmune and inflammatory diseases. Established in 2017, the company aims to address immune system dysregulation, providing treatment options for conditions that currently have limited or inadequate therapies. Q32 Bio's pipeline includes ADX-914, a human anti-IL-7R antibody designed to re-regulate adaptive immune function, and ADX-097, which demonstrates effective distribution to affected tissues and robust efficacy. With a team of experienced scientists and industry professionals, Q32 Bio is dedicated to restoring healthy immune balance through novel biologic therapies that target critical pathways in both the innate and adaptive immune systems.

Spruce Biosciences, Inc. is a biopharmaceutical company based in Daly City, California, specializing in the development and commercialization of innovative therapies for rare endocrine disorders. Founded in 2014, the company is primarily focused on its lead product candidate, tildacerfont, which is undergoing clinical trials for adult and pediatric patients with classic congenital adrenal hyperplasia (CAH). Tildacerfont is being developed as a non-steroidal therapy aimed at improving disease management and reducing reliance on steroids for affected patients. Additionally, the company is exploring the use of tildacerfont for females with polycystic ovary syndrome. With a commitment to addressing the unmet medical needs of patients with rare endocrine conditions, Spruce Biosciences aims to enhance the quality of life for those who have been historically underserved by existing treatment options. The company also has a partnership with Eli Lilly and Company to explore further pharmaceutical applications of its compounds.

Jasper Therapeutics, Inc. is a clinical-stage biotechnology company based in Menlo Park, California, that specializes in developing therapeutic agents for hematopoietic stem cell transplants and gene therapies. Founded in 2018, the company aims to enhance the safety and efficacy of conditioning agents to broaden the application of curative therapies. Jasper's lead product, JSP191, is a humanized monoclonal antibody currently in clinical development, designed to act as a conditioning agent by selectively clearing hematopoietic stem cells from bone marrow in patients undergoing stem cell transplants. The company also utilizes an engineered hematopoietic stem cells platform to address the limitations of transplant grafts, thereby increasing the accessibility of both allogeneic and autologous gene-edited hematopoietic stem cell therapies for a larger patient population.

Jasper Therapeutics, Inc. is a clinical-stage biotechnology company based in Menlo Park, California, that specializes in developing therapeutic agents for hematopoietic stem cell transplants and gene therapies. Founded in 2018, the company aims to enhance the safety and efficacy of conditioning agents to broaden the application of curative therapies. Jasper's lead product, JSP191, is a humanized monoclonal antibody currently in clinical development, designed to act as a conditioning agent by selectively clearing hematopoietic stem cells from bone marrow in patients undergoing stem cell transplants. The company also utilizes an engineered hematopoietic stem cells platform to address the limitations of transplant grafts, thereby increasing the accessibility of both allogeneic and autologous gene-edited hematopoietic stem cell therapies for a larger patient population.

IFM Therapeutics is a biotechnology company focused on developing small molecule medicines that target the innate immune system. It collaborates with academic institutions to leverage expertise in innate immunity alongside experienced drug discovery professionals. The company's subsidiary, IFM Due, specializes in discovering and developing antagonists of the cGAS/STING pathway, aiming to treat conditions such as inflammation, neuroinflammation, autoimmunity, and cancer. Additionally, IFM Discovery operates as an incubator within the company, working on genetically validated targets to create next-generation therapies for similar health challenges. Through its innovative approaches, IFM Therapeutics seeks to enhance immunotherapy and provide solutions for patients with serious diseases.

Phathom Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Buffalo Grove, Illinois, that specializes in developing and commercializing innovative treatments for gastrointestinal diseases. Incorporated in 2018, the company has rights in the United States, Europe, and Canada for vonoprazan, a potassium-competitive acid blocker (P-CAB) designed to inhibit acid secretion in the stomach. Currently, vonoprazan is undergoing Phase III clinical trials for the treatment of erosive gastroesophageal reflux disease and is also being evaluated in combination with antibiotics for addressing Helicobacter pylori infection. Phathom Pharmaceuticals aims to meet the unmet medical needs of patients suffering from acid-related disorders by leveraging the expertise of its team, which comprises seasoned professionals from the gastrointestinal and pharmaceutical sectors.

Soleno Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to the development and commercialization of innovative therapeutics for rare diseases. The company's primary focus is on its lead candidate, Diazoxide Choline Controlled Release (DCCR), a once-daily oral tablet designed for the treatment of Prader-Willi Syndrome (PWS). DCCR contains diazoxide choline, a choline salt of diazoxide, which is a benzothiadiazine. Currently, the product is being evaluated in a Phase III clinical development program. Established in 1999 and headquartered in Redwood City, California, Soleno Therapeutics was formerly known as Capnia, Inc. before rebranding in May 2017.

Vaxcyte, Inc. is a preclinical-stage biotechnology company focused on developing innovative vaccines to prevent and treat infectious diseases globally. Headquartered in Foster City, California, Vaxcyte's lead candidate is VAX-24, a 24-valent investigational pneumococcal conjugate vaccine. The company is also advancing VAX-XP, which aims to address emerging strains of pneumococcal disease and antibiotic resistance. Additionally, Vaxcyte is developing VAX-A1, a conjugate vaccine for Group A Streptococcus, and VAX-PG, a novel therapeutic vaccine targeting periodontal disease. Utilizing a proprietary cell-free protein synthesis platform, Vaxcyte designs and produces the essential components of vaccines, enhancing their efficacy compared to traditional technologies. Founded in 2013 and originally named SutroVax, Vaxcyte rebranded in May 2020 to reflect its commitment to improving global health through superior vaccine development.

Attenua, Inc., founded in 2015 and based in San Mateo, California, is a biotech company dedicated to developing non-narcotic medicines for chronic cough and other debilitating conditions often overlooked by larger pharmaceutical companies. The company focuses on discovering small molecule drugs that could benefit millions of patients. Attenua has assembled a team of experienced scientists and advisors with backgrounds from prominent pharmaceutical companies such as Merck, GSK, AstraZeneca, and Genentech. Their goal is to create novel therapies for chronic respiratory disorders, aiming to improve the quality of life for patients suffering from these conditions.

Gynesonics, Inc. is a medical device company focused on developing innovative solutions for women's health, specifically addressing symptomatic uterine fibroids. Founded in 2005 and headquartered in Redwood City, California, with an additional location in Beuningen, the Netherlands, Gynesonics offers the Sonata System, a minimally invasive treatment that utilizes sonography guidance for the transcervical ablation of fibroids. This incision-free approach provides a safe and effective alternative to traditional surgical methods such as hysterectomy or myomectomy, aiming to alleviate severe menstrual symptoms associated with fibroids. Gynesonics is dedicated to improving the quality of care for women by offering advanced technologies that enhance treatment options in gynecology.

Nouscom is a biotechnology company focused on developing an immunotherapy platform that creates engineered viral vector vaccines for cancer treatment. The company's innovative platform leverages a portfolio of modified viral vectors, specifically designed for the efficient expression of long strings of tumor neoantigens. This approach is complemented by a toolkit that facilitates the induction of robust antitumor T-cell responses, effectively enhancing cancer-specific cellular immunity in patients. Through its research and development efforts, Nouscom aims to improve cancer treatment outcomes by harnessing the body's immune system to target and combat cancer cells.

Virion Biotherapeutics is a developer of biological antivirals aimed at enhancing therapeutics for respiratory viral infections. The company specializes in the prevention and treatment of influenza and respiratory syncytial virus (RSV). By creating broad-spectrum antiviral therapies, Virion Biotherapeutics enables healthcare providers to simplify and expedite treatment processes, eliminating the necessity for differential diagnosis in managing respiratory viral infections.

GTx, Inc. was a biopharmaceutical company focused on the discovery, development, and commercialization of innovative treatments for stress urinary incontinence and prostate cancer. The company specialized in selective androgen receptor modulators (SARMs) and selective androgen receptor degraders. Its notable product candidate, enobosarm (GTx-024), was in Phase II clinical trials aimed at treating various forms of breast cancer and offering solutions for postmenopausal women with stress urinary incontinence. Founded in 1997 and based in Memphis, Tennessee, GTx aimed to improve patient outcomes through its targeted therapeutic approaches. In 2019, GTx was acquired by Oncternal Therapeutics, marking the completion of a reverse merger transaction.

Realm Therapeutics is a biopharmaceutical company based in Malvern, Pennsylvania, focused on leveraging proprietary technologies to enhance health outcomes for adults and children. Initially established to develop therapies for immune-mediated diseases, the company is currently seeking opportunities to invest in, partner with, or acquire entities with potential in the life sciences sector. Realm Therapeutics aims to develop small molecule therapies targeting inflammatory diseases, with applications in dermatology and ophthalmology, as well as potential uses in other medical areas. Founded in 2016 and formerly known as PuriCore plc, Realm Therapeutics has limited operations and is a subsidiary of ESSA Pharma Inc.

Venatorx Pharmaceuticals, Inc. is a pharmaceutical company dedicated to the discovery and development of innovative anti-infective agents aimed at addressing multi-drug-resistant (MDR) bacterial infections and challenging viral infections. Founded in 2010 and headquartered in Malvern, Pennsylvania, the company specializes in creating antibacterial drugs that target resistant pathogens, including those responsible for difficult-to-treat infections such as MRSA, Pseudomonas, and Salmonella. By employing novel chemical approaches, Venatorx develops treatments with selective and potent activity against various bacterial resistance mechanisms, thereby enhancing the therapeutic options available to healthcare professionals and addressing significant unmet medical needs in the field of infectious diseases.

Vaxcyte, Inc. is a preclinical-stage biotechnology company focused on developing innovative vaccines to prevent and treat infectious diseases globally. Headquartered in Foster City, California, Vaxcyte's lead candidate is VAX-24, a 24-valent investigational pneumococcal conjugate vaccine. The company is also advancing VAX-XP, which aims to address emerging strains of pneumococcal disease and antibiotic resistance. Additionally, Vaxcyte is developing VAX-A1, a conjugate vaccine for Group A Streptococcus, and VAX-PG, a novel therapeutic vaccine targeting periodontal disease. Utilizing a proprietary cell-free protein synthesis platform, Vaxcyte designs and produces the essential components of vaccines, enhancing their efficacy compared to traditional technologies. Founded in 2013 and originally named SutroVax, Vaxcyte rebranded in May 2020 to reflect its commitment to improving global health through superior vaccine development.

GammaDelta Therapeutics focuses on developing innovative immunotherapies utilizing gamma delta (γδ) T cells to treat cancer and autoimmune diseases. The company aims to harness the unique properties of tissue resident γδ T cells to enhance the effectiveness of immunotherapy. By leveraging these specialized immune cells, GammaDelta Therapeutics seeks to provide patients with improved treatment options that can significantly impact their health outcomes in the face of serious diseases.

IFM Therapeutics is a biotechnology company focused on developing small molecule medicines that target the innate immune system. It collaborates with academic institutions to leverage expertise in innate immunity alongside experienced drug discovery professionals. The company's subsidiary, IFM Due, specializes in discovering and developing antagonists of the cGAS/STING pathway, aiming to treat conditions such as inflammation, neuroinflammation, autoimmunity, and cancer. Additionally, IFM Discovery operates as an incubator within the company, working on genetically validated targets to create next-generation therapies for similar health challenges. Through its innovative approaches, IFM Therapeutics seeks to enhance immunotherapy and provide solutions for patients with serious diseases.

Verona Pharma plc is a clinical-stage biopharmaceutical company based in London, dedicated to developing and commercializing innovative therapies for respiratory diseases with significant unmet medical needs. Founded in 2005, the company primarily focuses on its lead product candidate, ensifentrine, an inhaled dual inhibitor of phosphodiesterase enzymes 3 and 4, which functions as both a bronchodilator and an anti-inflammatory agent. Ensifentrine is currently in Phase 2b clinical development as a nebulized formulation for the maintenance treatment of chronic obstructive pulmonary disease (COPD), with additional formulations including a dry powder inhaler and a pressurized metered-dose inhaler also under development. In addition to COPD, Verona Pharma is exploring the use of ensifentrine for other respiratory conditions, including cystic fibrosis and asthma, thereby aiming to enhance the health and quality of life for patients suffering from these chronic disorders.

Tizona Therapeutics, Inc. is a biotechnology company focused on developing immunotherapies for cancer and autoimmune diseases. Founded in 2014 and based in South San Francisco, California, the company is engaged in creating innovative treatments that target immunosuppressive cells and mechanisms within the tumor microenvironment. Its product pipeline includes an Anti-CCR4 antibody for cancer therapy, as well as IL-35 antagonists and agonists aimed at addressing both cancer and autoimmune conditions. Tizona is also collaborating with its scientific founders to investigate the role of regulatory T cells in various tumors, enhancing the understanding of their contribution to immunosuppression. This research aims to differentiate the company’s approach and improve patient outcomes by facilitating complete and lasting remissions.

eFFECTOR Therapeutics, Inc. is a clinical-stage biotechnology company based in San Diego, California, that specializes in the development of selective translation regulators for the treatment of cancer and other serious diseases. Founded in 2012, the company is pioneering a new class of oncology drugs known as selective translation regulator inhibitors (STRIs). These drug candidates specifically target the eIF4F complex and its associated kinase, MNK 1/2, which play critical roles in protein synthesis and are linked to prominent cancer signaling pathways such as PI3K-AKT and RAS-MEK. eFFECTOR's products aim to inhibit pathways that drive tumor growth, survival, and immune evasion by regulating the expression of oncoproteins and immunosuppressive proteins. The lead candidate, tomivosertib, is currently being evaluated in a Phase 2b trial for non-small cell lung cancer in combination with pembrolizumab. Additionally, zotatifin, an inhibitor of eIF4A, is undergoing dose-escalation in a Phase 1/2 trial, with further expansion cohorts anticipated. The company also collaborates with Pfizer to advance inhibitors targeting eIF4E.

Kesios Therapeutics, established in 2012, is a UK-based biopharmaceutical company focused on developing small molecule drugs for haematological malignancies, primarily multiple myeloma. The company's pipeline targets key pathways like NF-κB and GADD45β/MKK7, aiming to address unmet medical needs in oncology.

GenSight Biologics S.A. is a clinical-stage biotechnology company based in Paris, France, focused on the discovery and development of gene therapies for retinal degenerative diseases and neurodegenerative disorders of the central nervous system. Founded in 2012, the company utilizes innovative technologies, including mitochondrial targeting sequences and optogenetics, to develop treatments that aim to preserve or restore vision in patients with severe vision impairments. Its lead product candidates include GS010, an AAV2-based gene therapy that is currently undergoing Phase III clinical trials for Leber hereditary optic neuropathy caused by mutations in the ND4 gene, and GS030, which is in Phase I/II trials for retinitis pigmentosa and geographic atrophy associated with dry age-related macular degeneration. GenSight Biologics is also advancing other product candidates in preclinical development targeting various ophthalmic and neurodegenerative conditions.

Vaxcyte, Inc. is a preclinical-stage biotechnology company focused on developing innovative vaccines to prevent and treat infectious diseases globally. Headquartered in Foster City, California, Vaxcyte's lead candidate is VAX-24, a 24-valent investigational pneumococcal conjugate vaccine. The company is also advancing VAX-XP, which aims to address emerging strains of pneumococcal disease and antibiotic resistance. Additionally, Vaxcyte is developing VAX-A1, a conjugate vaccine for Group A Streptococcus, and VAX-PG, a novel therapeutic vaccine targeting periodontal disease. Utilizing a proprietary cell-free protein synthesis platform, Vaxcyte designs and produces the essential components of vaccines, enhancing their efficacy compared to traditional technologies. Founded in 2013 and originally named SutroVax, Vaxcyte rebranded in May 2020 to reflect its commitment to improving global health through superior vaccine development.

Median Technologies SA is a company that specializes in developing and marketing software products for medical image analysis, primarily focused on oncology. Founded in 2002 and based in Valbonne, France, the company offers two main platforms: iBiopsy, which utilizes AI for biomarker identification and patient profiling through CT scans, and iSee, designed for image analysis and management in clinical trials. Median Technologies aims to enhance the diagnosis of cancer patients and assess their treatment responses by standardizing and automating medical image interpretation. The company operates in two main markets: drug development and patient care, and collaborates with a contract research organization to provide integrated imaging services for clinical trials. Additionally, it has partnered with Canon to innovate new imaging technologies for the patient care sector.

CRISPR Therapeutics AG is a biotechnology company based in Zug, Switzerland, dedicated to developing transformative gene-based medicines for serious human diseases using CRISPR/Cas9 technology. This revolutionary gene-editing platform allows for precise changes to genomic DNA. The company's portfolio includes therapeutic programs targeting hemoglobinopathies, oncology, regenerative medicine, and rare diseases. Their lead product candidate is CTX001, a gene-edited therapy for transfusion-dependent beta thalassemia or severe sickle cell disease, which has been approved as Casgevy in collaboration with Vertex Pharmaceuticals. Additionally, CRISPR Therapeutics is developing CTX110, an allogeneic CAR-T therapy targeting CD19-positive malignancies, and other programs like CTX120 for multiple myeloma and CTX130 for solid tumors and hematologic malignancies. The company also engages in regenerative medicine programs for diabetes and genetic disease treatments such as glycogen storage disease Ia, Duchenne muscular dystrophy, and cystic fibrosis. CRISPR Therapeutics has strategic partnerships with Bayer Healthcare LLC, Vertex Pharmaceuticals Incorporated, and ViaCyte, Inc.

CRISPR Therapeutics AG is a biotechnology company based in Zug, Switzerland, dedicated to developing transformative gene-based medicines for serious human diseases using CRISPR/Cas9 technology. This revolutionary gene-editing platform allows for precise changes to genomic DNA. The company's portfolio includes therapeutic programs targeting hemoglobinopathies, oncology, regenerative medicine, and rare diseases. Their lead product candidate is CTX001, a gene-edited therapy for transfusion-dependent beta thalassemia or severe sickle cell disease, which has been approved as Casgevy in collaboration with Vertex Pharmaceuticals. Additionally, CRISPR Therapeutics is developing CTX110, an allogeneic CAR-T therapy targeting CD19-positive malignancies, and other programs like CTX120 for multiple myeloma and CTX130 for solid tumors and hematologic malignancies. The company also engages in regenerative medicine programs for diabetes and genetic disease treatments such as glycogen storage disease Ia, Duchenne muscular dystrophy, and cystic fibrosis. CRISPR Therapeutics has strategic partnerships with Bayer Healthcare LLC, Vertex Pharmaceuticals Incorporated, and ViaCyte, Inc.

Tobira Therapeutics, Inc. is a biotechnology company based in Princeton, New Jersey, focused on the research, development, and commercialization of antiviral compounds aimed at addressing life-threatening infectious diseases. Founded in 2006, the company specializes in developing TBR-652 and TBR-220 antagonists specifically for the treatment of HIV/AIDS and hepatitis, along with other related infectious conditions. Through its innovative approach, Tobira Therapeutics seeks to provide effective therapies for patients suffering from these serious health challenges.

Chiasma, Inc. is a late-stage biopharmaceutical company based in Needham, Massachusetts, established in 2001. The company specializes in developing oral medications using its proprietary Transient Permeability Enhancer technology, which allows for the conversion of injectable drugs to oral formulations. This platform not only enhances drug absorption but also enables the exploration of new indications for existing therapies. Chiasma's primary product is MYCAPSSA, an oral formulation of octreotide capsules designed for the treatment of acromegaly, a condition characterized by excessive production of growth hormone. Currently, MYCAPSSA is undergoing Phase III clinical trials in the United States and is also being developed for regulatory approval in the European Union, targeting adult patients with this rare and serious condition.

Personalis, Inc. is a cancer genomics company based in Menlo Park, California, that specializes in genomic sequencing and data analysis services aimed at advancing personalized cancer therapies. Established in 2011, the company offers a range of products, including the NeXT Platform, which provides critical data for the development of personalized therapies, therapy selection, and diagnostics. Additionally, Personalis provides a liquid biopsy assay that examines various human genes to enhance cancer treatment strategies. The company's services support biopharmaceutical clients, universities, non-profit organizations, diagnostics companies, and government agencies, facilitating the creation of safer and more effective precision cancer therapies and immunotherapies. Personalis is recognized for its integration of sequencing technology and data interpretation, contributing to a comprehensive understanding of tumor biology and its interaction with the immune system.

Median Technologies SA is a company that specializes in developing and marketing software products for medical image analysis, primarily focused on oncology. Founded in 2002 and based in Valbonne, France, the company offers two main platforms: iBiopsy, which utilizes AI for biomarker identification and patient profiling through CT scans, and iSee, designed for image analysis and management in clinical trials. Median Technologies aims to enhance the diagnosis of cancer patients and assess their treatment responses by standardizing and automating medical image interpretation. The company operates in two main markets: drug development and patient care, and collaborates with a contract research organization to provide integrated imaging services for clinical trials. Additionally, it has partnered with Canon to innovate new imaging technologies for the patient care sector.

Paratek Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company based in Boston, Massachusetts, specializing in the development and commercialization of innovative therapies derived from novel tetracycline chemistry. The company’s lead product, NUZYRA, is a broad-spectrum antibiotic administered in both oral and intravenous forms, targeting adult patients with community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. Another significant product, SEYSARA, is designed for the treatment of moderate to severe acne vulgaris. Paratek has received Qualified Infectious Disease Product designation from the U.S. Food and Drug Administration for its lead antibiotic, reflecting its commitment to addressing urgent public health threats, including antibiotic resistance. The company maintains various collaboration agreements, including partnerships with Zai Lab and Allergan, as well as research agreements with academic institutions and military organizations, to further its mission in combating infectious diseases and exploring additional therapeutic areas such as multiple sclerosis and systemic inflammatory diseases.

Valeritas Holdings, Inc. was a medical technology company focused on developing and commercializing innovative solutions for the treatment of Type 2 diabetes. Founded in 2006 and headquartered in Bridgewater, New Jersey, the company offered the V-Go, a wearable insulin delivery device designed for basal-bolus therapy, allowing patients to manage their insulin intake conveniently and discreetly. Valeritas was also working on additional products, including the V-Go Prefill, aimed at simplifying the device-filling process, and V-Go SIM, which would facilitate real-time tracking of dosing utilization. The company marketed its products through third-party wholesalers and medical supply distributors, aiming to enhance the health and quality of life for individuals living with diabetes. However, on June 30, 2020, Valeritas Holdings filed for Chapter 11 bankruptcy, leading to its cessation of operations.

Gynesonics, Inc. is a medical device company focused on developing innovative solutions for women's health, specifically addressing symptomatic uterine fibroids. Founded in 2005 and headquartered in Redwood City, California, with an additional location in Beuningen, the Netherlands, Gynesonics offers the Sonata System, a minimally invasive treatment that utilizes sonography guidance for the transcervical ablation of fibroids. This incision-free approach provides a safe and effective alternative to traditional surgical methods such as hysterectomy or myomectomy, aiming to alleviate severe menstrual symptoms associated with fibroids. Gynesonics is dedicated to improving the quality of care for women by offering advanced technologies that enhance treatment options in gynecology.

Senseonics Holdings, Inc. is a medical technology company based in Germantown, Maryland, specializing in the development and commercialization of continuous glucose monitoring (CGM) systems for individuals with diabetes. Founded in 1996, the company focuses on innovative and long-term implantable glucose monitoring solutions that utilize advanced fluorescence sensing technology. Its flagship products, Eversense and Eversense XL, are implantable CGM systems designed to monitor glucose levels for up to 90 and 180 days, respectively. These products aim to provide users with a reliable and stable means of glucose management, enhancing their ability to live confidently and manage their diabetes effectively. The majority of Senseonics' revenue comes from international markets, reflecting its strong presence in Europe.

Wilson Therapeutics, headquartered in Stockholm, Sweden, specializes in developing innovative treatments for rare diseases, primarily focusing on Wilson Disease, a condition caused by excessive copper accumulation. The company's lead product, Decuprate®, is currently undergoing Phase II clinical trials as a potential new therapy for Wilson Disease patients.

Pixium Vision SA is a bioelectronics company based in Paris, France, focused on developing innovative implantable medical devices aimed at restoring vision for individuals blinded by the degeneration of photoreceptor cells in the retina. The company’s flagship product, the PRIMA System, is a bionic vision system designed to improve visual acuity and enhance the independence of patients. Pixium Vision also works on the Intelligent Retinal Implantable System (IRIS1), which is currently undergoing clinical trials, and is developing two subsequent generations, IRIS2 and IRIS3, each designed to provide improved visual capabilities through advanced technologies. Founded in 2011 as a spin-out from the Vision Institute and Université Pierre et Marie Curie, Pixium collaborates with prestigious institutions such as Stanford University and Moorfields Eye Hospital to further its research and development efforts in retinal implant systems.

Personalis, Inc. is a cancer genomics company based in Menlo Park, California, that specializes in genomic sequencing and data analysis services aimed at advancing personalized cancer therapies. Established in 2011, the company offers a range of products, including the NeXT Platform, which provides critical data for the development of personalized therapies, therapy selection, and diagnostics. Additionally, Personalis provides a liquid biopsy assay that examines various human genes to enhance cancer treatment strategies. The company's services support biopharmaceutical clients, universities, non-profit organizations, diagnostics companies, and government agencies, facilitating the creation of safer and more effective precision cancer therapies and immunotherapies. Personalis is recognized for its integration of sequencing technology and data interpretation, contributing to a comprehensive understanding of tumor biology and its interaction with the immune system.

Dicerna Pharmaceuticals is a biopharmaceutical company that specializes in the discovery and development of RNA interference (RNAi)-based therapeutics. The company focuses on innovative treatments for rare inherited liver diseases, viral infections, chronic liver diseases, and cardiometabolic conditions. Utilizing its proprietary GalXC RNAi technology platform, Dicerna is advancing several key product candidates, including nedosiran for primary hyperoxaluria, RG6346 for chronic hepatitis B, and programs targeting genetic liver diseases and cardiovascular conditions. Founded in 2007 and headquartered in Lexington, Massachusetts, Dicerna has established strategic collaborations with major pharmaceutical firms to enhance its research and development efforts.

eFFECTOR Therapeutics, Inc. is a clinical-stage biotechnology company based in San Diego, California, that specializes in the development of selective translation regulators for the treatment of cancer and other serious diseases. Founded in 2012, the company is pioneering a new class of oncology drugs known as selective translation regulator inhibitors (STRIs). These drug candidates specifically target the eIF4F complex and its associated kinase, MNK 1/2, which play critical roles in protein synthesis and are linked to prominent cancer signaling pathways such as PI3K-AKT and RAS-MEK. eFFECTOR's products aim to inhibit pathways that drive tumor growth, survival, and immune evasion by regulating the expression of oncoproteins and immunosuppressive proteins. The lead candidate, tomivosertib, is currently being evaluated in a Phase 2b trial for non-small cell lung cancer in combination with pembrolizumab. Additionally, zotatifin, an inhibitor of eIF4A, is undergoing dose-escalation in a Phase 1/2 trial, with further expansion cohorts anticipated. The company also collaborates with Pfizer to advance inhibitors targeting eIF4E.

GenSight Biologics S.A. is a clinical-stage biotechnology company based in Paris, France, focused on the discovery and development of gene therapies for retinal degenerative diseases and neurodegenerative disorders of the central nervous system. Founded in 2012, the company utilizes innovative technologies, including mitochondrial targeting sequences and optogenetics, to develop treatments that aim to preserve or restore vision in patients with severe vision impairments. Its lead product candidates include GS010, an AAV2-based gene therapy that is currently undergoing Phase III clinical trials for Leber hereditary optic neuropathy caused by mutations in the ND4 gene, and GS030, which is in Phase I/II trials for retinitis pigmentosa and geographic atrophy associated with dry age-related macular degeneration. GenSight Biologics is also advancing other product candidates in preclinical development targeting various ophthalmic and neurodegenerative conditions.

Avedro, Inc. is a commercial-stage ophthalmic pharmaceutical and medical device company headquartered in Waltham, Massachusetts. The company specializes in developing and commercializing innovative products for treating corneal disorders, primarily focusing on corneal ectatic conditions and refractive issues. Avedro's proprietary Corneal Remodeling Platform includes the KXL and Mosaic systems, which utilize ultraviolet A (UVA) light in conjunction with riboflavin drug formulations for corneal cross-linking. This technology is aimed at strengthening and reshaping the cornea through minimally invasive and non-invasive outpatient procedures. Avedro has also introduced the Keraflex refractive correction procedure, a non-invasive technique for flattening the cornea without tissue removal. While Avedro primarily serves ophthalmologists, hospitals, and ambulatory surgery centers in the United States, it also markets its products internationally through medical device distributors. The company, originally named ThermalVision, Inc., was incorporated in 2002 and rebranded as Avedro in 2005. As of November 2019, Avedro operates as a subsidiary of Glaukos Corporation.

Gynesonics, Inc. is a medical device company focused on developing innovative solutions for women's health, specifically addressing symptomatic uterine fibroids. Founded in 2005 and headquartered in Redwood City, California, with an additional location in Beuningen, the Netherlands, Gynesonics offers the Sonata System, a minimally invasive treatment that utilizes sonography guidance for the transcervical ablation of fibroids. This incision-free approach provides a safe and effective alternative to traditional surgical methods such as hysterectomy or myomectomy, aiming to alleviate severe menstrual symptoms associated with fibroids. Gynesonics is dedicated to improving the quality of care for women by offering advanced technologies that enhance treatment options in gynecology.

Labcyte Inc., founded in 2000 and based in San Jose, California, specializes in developing acoustic droplet ejection (ADE) technology for various applications in the life sciences. The company's innovative approach uses focused beams of acoustic energy to precisely dispense nanoliter-scale droplets of fluid from one plate to another, enabling high accuracy at low volumes and reducing consumables costs. Labcyte's products include automation systems, laboratory workstations, and control software, which are utilized in drug discovery, genomics research, cancer research, and personalized medicine. The company operates as a subsidiary of Beckman Coulter, Inc., with additional offices across multiple countries including Canada, the United Kingdom, Australia, India, South Korea, China, Hong Kong, Japan, Singapore, and Taiwan.

Chiasma, Inc. is a late-stage biopharmaceutical company based in Needham, Massachusetts, established in 2001. The company specializes in developing oral medications using its proprietary Transient Permeability Enhancer technology, which allows for the conversion of injectable drugs to oral formulations. This platform not only enhances drug absorption but also enables the exploration of new indications for existing therapies. Chiasma's primary product is MYCAPSSA, an oral formulation of octreotide capsules designed for the treatment of acromegaly, a condition characterized by excessive production of growth hormone. Currently, MYCAPSSA is undergoing Phase III clinical trials in the United States and is also being developed for regulatory approval in the European Union, targeting adult patients with this rare and serious condition.

Sonitus Medical Inc. is a privately held medical device company based in San Mateo, California, focused on delivering innovative hearing solutions for patients with hearing challenges. The company specializes in bone conduction hearing devices and markets the SoundBite Hearing System, which is recognized as the world's first non-invasive and removable hearing solution that transmits sound through the teeth. This nearly invisible in-the-mouth hearing system is designed to address single-sided deafness and conductive hearing loss, providing a simple and non-surgical alternative for patients. The device is currently FDA cleared as a prosthetic for these specific conditions. Sonitus Medical aims to expand its technology to include treatments for mixed hearing loss and tinnitus, as well as applications in consumer and covert communications. Founded in 2006, Sonitus Medical is emerging as a leader in the field of hearing solutions.

Sientra is a medical device company based in Santa Barbara, California, specializing in breast implant treatments for both augmentation and reconstruction. Founded by Hani Zeini, the company develops innovative implantable devices that cater to the needs of plastic surgeons. Sientra's product offerings include silicone gel breast implants, breast tissue expanders, and silicone scar treatment solutions, focusing on providing elegant and intuitive options for cosmetic and reconstructive surgery. The company's commitment to quality and innovation positions it as a significant player in the surgical aesthetics market.

Kuros Biosciences AG is a biopharmaceutical company based in Schlieren, Switzerland, dedicated to the discovery, development, and commercialization of innovative products for tissue repair and regeneration. Founded in 2000 as a spin-off from the Eidgenössische Technische Hochschule Zürich, Kuros has developed a robust pipeline of biopharmaceuticals targeting chronic diseases. Its key products include Neuroseal, a novel biomaterial for dural sealing, and the MagnetOs family of bone graft substitutes used in orthopedic, spinal, and dental applications. MagnetOs is approved for use in the EU and the US, with further formulations under development for regulatory submission. Kuros also has a range of clinical-stage products, including KUR-111 and KUR-113, which have completed Phase II clinical trials for treating specific bone fractures. The company has engaged in significant clinical research, enrolling over 600 patients in multinational trials, generating promising data regarding safety and efficacy in various applications, particularly within orthobiologics.

Prosensa, also known as Ribpharm Inc, is a biotech company specializing in the discovery, development, and commercialization of RNA-based therapeutics. The company is particularly focused on addressing genetic disorders, with an emphasis on neuromuscular conditions, as well as anti-infectives and oncology. Prosensa aims to leverage its strong intellectual property position to capitalize on emerging market opportunities in the healthcare sector. To optimize its operations, the company adopts a focused business model by outsourcing most activities to specialized organizations. Through its innovative approach, Prosensa seeks to bring novel and commercially viable therapeutic products to market.

Valeritas Holdings, Inc. was a medical technology company focused on developing and commercializing innovative solutions for the treatment of Type 2 diabetes. Founded in 2006 and headquartered in Bridgewater, New Jersey, the company offered the V-Go, a wearable insulin delivery device designed for basal-bolus therapy, allowing patients to manage their insulin intake conveniently and discreetly. Valeritas was also working on additional products, including the V-Go Prefill, aimed at simplifying the device-filling process, and V-Go SIM, which would facilitate real-time tracking of dosing utilization. The company marketed its products through third-party wholesalers and medical supply distributors, aiming to enhance the health and quality of life for individuals living with diabetes. However, on June 30, 2020, Valeritas Holdings filed for Chapter 11 bankruptcy, leading to its cessation of operations.

Personalis, Inc. is a cancer genomics company based in Menlo Park, California, that specializes in genomic sequencing and data analysis services aimed at advancing personalized cancer therapies. Established in 2011, the company offers a range of products, including the NeXT Platform, which provides critical data for the development of personalized therapies, therapy selection, and diagnostics. Additionally, Personalis provides a liquid biopsy assay that examines various human genes to enhance cancer treatment strategies. The company's services support biopharmaceutical clients, universities, non-profit organizations, diagnostics companies, and government agencies, facilitating the creation of safer and more effective precision cancer therapies and immunotherapies. Personalis is recognized for its integration of sequencing technology and data interpretation, contributing to a comprehensive understanding of tumor biology and its interaction with the immune system.

MD On-Line Inc. is a prominent provider of electronic data interchange (EDI) solutions that streamline interactions between healthcare providers and payers in the United States. The company specializes in electronic data capture, claim submission, and transactional services, enhancing the efficiency of the healthcare system by reducing operational inefficiencies. It offers a range of services, including real-time eligibility verification, referrals, claim status inquiries, and electronic remittance advice. MD On-Line's solutions are co-branded and endorsed by over 30 major insurers, and they cater to more than 45,000 healthcare providers across the nation. Its extensive network includes over 2,000 payer organizations, positioning MD On-Line as a key player in healthcare transaction management. The company's WebLink service allows providers with practice management software to manage claims effectively, while it also provides solutions for those without such software, ensuring comprehensive support for various electronic transactions.

Lombard Medical, Inc. is a medical technology company that specializes in developing, manufacturing, and marketing endovascular stent-grafts for the repair of aortic aneurysms. Its principal product, Aorfix, is designed to treat abdominal aortic aneurysms (AAAs) in patients with neck angulations of up to 90 degrees. The company's product portfolio also includes the Altura endovascular stent-graft system for standard AAA anatomies, and advanced delivery systems like Aorflex and IntelliFlex LP, which enhance the precision of stent-graft deployment. Lombard Medical markets its products through a direct sales force and distributors, primarily targeting state- or government-owned hospitals. Established in 2000 and headquartered in Didcot, the United Kingdom, Lombard Medical serves various international markets, with a significant portion of its revenue derived from Japan.

Syntaxin is a biopharmaceutical company that engineers and develops bacterial-based protein therapeutics for the treatment of neurological, inflammatory and endocrine diseases. The biopharmaceutical company's proprietary technology platform enables the engineering of bacterial proteins by domain substitution, to produce novel cell-specific biotherapeutics that inhibit cell secretion. These products can have therapeutic effects in a wide range of indications.

IS Pharma plc is a pharmaceutical and medical device company based in Chester, United Kingdom. It specializes in the development, acquisition, and commercialization of products primarily in the fields of critical care, oncology, and neurology. The company's commercial offerings include a range of products such as Volplex, a sterile plasma substitute; Cryogesic and Dermogesic, topical analgesic sprays; Mysoline, an oral treatment for epilepsy and essential tremor; Aloxi, a nausea and vomiting antagonist; and Isoplex, a gelatin-based fluid volume replacement solution. IS Pharma is also advancing several late-stage development products, including Haemopressin, Acoranil, AquiHex, and Gentispray, which address various medical needs. Additionally, the company has partnered products like OptiFlo, a line of catheter irrigation solutions, and is developing Micelle Nanotechnology for drug delivery in collaboration with Plethora Solutions Holdings PLC. Formerly known as Maelor plc, IS Pharma plc adopted its current name in April 2008.

Pathwork Diagnostics, located in Redwood City, California, specializes in the development of molecular diagnostics for oncology. The company is known for its Pathwork Tissue of Origin Test, which was the first microarray-based gene expression test to receive FDA clearance. This innovative test assists in the identification of challenging tumors, including poorly differentiated, undifferentiated, and metastatic cancers. Pathwork Diagnostics offers lab services for various specimen types, including formalin-fixed, paraffin-embedded, and frozen samples, leveraging genomic information to enhance tumor classification and support oncological decision-making.

Zogenix, Inc. is a pharmaceutical company focused on developing and commercializing innovative therapies for patients with rare diseases, particularly within the central nervous system. The company is headquartered in Emeryville, California, and was established in 2006. Its lead product candidate, Fintepla, is a low-dose fenfluramine currently undergoing Phase III clinical trials for the treatment of seizures related to Dravet syndrome and Lennox-Gastaut syndrome. Additionally, it is being investigated in Phase II trials for other rare epileptic conditions. Zogenix is also developing MT1621, a therapy aimed at treating inherited mitochondrial DNA depletion disorders. Furthermore, the company collaborates with Tevard Biosciences to explore gene therapies for Dravet syndrome and similar genetic epilepsies. By focusing on therapies that address significant unmet medical needs, Zogenix aims to enhance the quality of life for patients and their families.

Avila Therapeutics is a biotechnology company based in Waltham, Massachusetts, focused on the design and development of covalent drugs targeting viral infections, cancers, and autoimmune diseases. The company is known for its small molecule hepatitis C virus protease inhibitor, AVL-181. Established in 2006, Avila Therapeutics has formed a strategic alliance with Sanofi-Aventis to enhance its research and development efforts. As of 2012, Avila Therapeutics operates as a subsidiary of Celgene Corporation, continuing its commitment to advancing innovative therapeutic solutions.

Oxagen Limited is a biopharmaceutical company based in London, United Kingdom, focused on developing and commercializing anti-inflammatory medicines to treat asthma and other chronic allergic conditions. The company specializes in small molecule drugs that target the CRTH2 receptor, which plays a key role in initiating and maintaining allergic responses. Oxagen's pipeline includes OC000459, an oral CRTH2 antagonist designed for eosinophilic asthma and allergic rhinoconjunctivitis. Additionally, the company addresses various inflammatory diseases such as autoimmune disease, inflammatory bowel disease, psoriasis, allergy, and rheumatoid arthritis. Founded in 1996, Oxagen serves customers globally, including in the United Kingdom, Russia, CIS countries, and other international markets.

PrimeraDx, Inc. specializes in multiplexed infectious disease assays, focusing on advanced diagnostic technologies. The company offers Scalable Target Amplification Routine technology, enabling the simultaneous quantitative measurement of multiple target nucleic acids. Its product lineup includes ViraQuant, a multiplexed assay for the quantitative measurement of various viruses, as well as FungiQuant Yeast and FungiQuant Mold, which are fungal panels used in mycology testing. Additionally, PrimeraDx provides an instrument designed for the simultaneous detection and quantification of diverse target types, such as mRNA, miRNA, SNPs, and DNA. These products are utilized in various applications, including miRNA analysis, DNA methylation, quantitative genotyping, gene expression, and viral load measurement. Founded in 2004, PrimeraDx is headquartered in Mansfield, Massachusetts.

Amarin Corporation plc, a pharmaceutical company based in Dublin, Ireland, develops and markets therapeutics for cardiovascular disease treatment. Its primary product, Vascepa, is a prescription omega-3 fatty acid capsule used to lower triglyceride levels in adults with severe hypertriglyceridemia. Amarin also has a pipeline for REDUCE-IT, targeting patients with high triglyceride levels on statin therapy. The company sells its products through a direct sales force to wholesalers and specialty pharmacies, and collaborates with Mochida Pharmaceutical Co., Ltd. for further drug development. Amarin's expertise lies in lipid science and the therapeutic benefits of essential fatty acids in cardiovascular disease management.

Zogenix, Inc. is a pharmaceutical company focused on developing and commercializing innovative therapies for patients with rare diseases, particularly within the central nervous system. The company is headquartered in Emeryville, California, and was established in 2006. Its lead product candidate, Fintepla, is a low-dose fenfluramine currently undergoing Phase III clinical trials for the treatment of seizures related to Dravet syndrome and Lennox-Gastaut syndrome. Additionally, it is being investigated in Phase II trials for other rare epileptic conditions. Zogenix is also developing MT1621, a therapy aimed at treating inherited mitochondrial DNA depletion disorders. Furthermore, the company collaborates with Tevard Biosciences to explore gene therapies for Dravet syndrome and similar genetic epilepsies. By focusing on therapies that address significant unmet medical needs, Zogenix aims to enhance the quality of life for patients and their families.

Intellikine is a biopharmaceutical company focused on the discovery and development of innovative small molecule therapies that target the PI3K/Akt/mTOR signaling pathway. The company specializes in creating drugs designed to treat various conditions, including cancer, inflammation, and autoimmune disorders. Its product portfolio features several notable candidates, such as INK128, an orally-available inhibitor that targets TORC1/2 for solid tumor malignancies, and INK1197, a dual PI3K selective inhibitor aimed at treating immune-mediated inflammatory diseases like rheumatoid arthritis and asthma. Intellikine is dedicated to fostering a skilled team and a robust discovery platform to accelerate the development of kinase inhibitors that have the potential to lead to significant medical advancements.

Chroma Therapeutics Ltd., established in 2000, is a privately-held biotechnology company based in Abingdon, UK. It specializes in developing novel small molecule drugs for targeted cancer and inflammation treatments, drawing from chromatin biology and innovative cell accumulation approaches. The company's pipeline includes Tosedostat, an oral aminopeptidase inhibitor; CHR-3996, an optimized histone deacetylase inhibitor for cancer treatment; and CHR-2845, a targeted solution for hematological malignancies. Chroma has built a strong network of academic collaborators and holds the first systematic assembly of intellectual property in chromatin biology, aiming to create substantial shareholder value through its innovative product pipeline targeting high-prevalence diseases.

Clovis Oncology, Inc. is a biopharmaceutical company dedicated to acquiring, developing, and commercializing innovative cancer treatments in the United States, Europe, and other international markets. The company focuses on precision medicine, targeting specific cancer subsets to ensure that therapeutics are directed to patients who are most likely to benefit. Clovis Oncology's primary product is Rubraca, an oral small molecule inhibitor of poly ADP-ribose polymerase, approved for the treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer. Additionally, the company is developing lucitanib, an oral inhibitor targeting multiple tyrosine kinase receptors involved in cancer progression. Clovis distributes its products through specialty distributors and pharmacy providers, and it engages in various collaborations and licensing agreements with prominent pharmaceutical companies such as Pfizer, AstraZeneca, and Bristol-Myers Squibb. Founded in 2009 and headquartered in Boulder, Colorado, Clovis Oncology is committed to advancing cancer care through targeted therapeutic approaches.

SFJ Pharmaceuticals, Inc. is a specialty pharmaceutical company based in Pleasanton, California, that focuses on the clinical development and registration of pharmaceutical products, particularly in Japan. Founded in 2008, the company aims to accelerate the availability of innovative drugs in major markets by providing funding and strategic development expertise to its pharmaceutical and biotech partners. SFJ Pharmaceuticals addresses the challenges posed by budget cuts in research and development, particularly due to pressures such as the patent cliff affecting large pharmaceutical companies and the lack of external funding for biotech firms. By assuming 100% of the clinical and regulatory risk, SFJ Pharmaceuticals enables its partners to continue advancing their key drug candidates while minimizing the impact on their financial resources. The company utilizes a platform designed for late-stage trial design, execution, and regulatory registration, facilitating the development of vital pharmaceutical products across various therapeutic areas.

Algeta ASA is an oncology company headquartered in Oslo, Norway, that specializes in developing targeted therapies for cancer treatment using its proprietary alpha-pharmaceutical platform. Founded in 1997, the company focuses on fulfilling unmet medical needs in cancer care. Its lead product, radium-223 dichloride, has successfully completed Phase III clinical trials for treating castration-resistant prostate cancer with bone metastases. Additionally, Algeta is advancing its research on thorium-227, an alpha-emitter that is in the preclinical phase and is being developed in conjunction with tumor-targeting molecules to create targeted thorium conjugates. The company has a collaboration agreement with Bayer Pharma AG for the global development and commercialization of radium-223. Algeta was previously known as Anticancer Therapeutic Inventions AS before rebranding in 2003.

Hydra Biosciences, headquartered in Cambridge, Massachusetts, is a biopharmaceutical company dedicated to developing innovative drugs targeting pain, inflammation, and cardiovascular diseases. The company leverages its expertise in novel ion channels and proprietary high-throughput screening platforms to identify and advance drug candidates addressing substantial unmet medical needs. Hydra's focus lies in TRP ion channels, offering potential for selective and safer therapies compared to classical voltage-gated channels. Since its founding, Hydra has secured significant funding from prominent investors such as Abingworth Ventures, Advanced Technology Ventures, and New Enterprise Associates, among others.

Synosia Therapeutics is a privately-owned company focused on developing and commercializing products aimed at addressing unmet medical needs in psychiatry and neurology. The company has a pipeline that includes six clinical-stage compounds, which have been acquired through strategic partnerships with major pharmaceutical firms such as Novartis, Roche, and Syngenta. Among these compounds, two are already marketed drugs that are being evaluated for new therapeutic indications to expand their application in treating neurological and psychiatric conditions, including anxiety and Parkinson's disease. In addition to its drug development efforts, Synosia Therapeutics also offers clinical development programs and research services.