Amplitude Ventures

Reverb Therapeutics focuses on developing innovative treatments for cancer and other diseases through advanced cytokine therapy. The company specializes in using bispecific antibodies to target and localize endogenous cytokines to immune cells within the tumor microenvironment. This approach aims to enhance targeted immune activation while minimizing the toxicity commonly associated with exogenously delivered cytokines. By leveraging the body's own cytokines, Reverb Therapeutics seeks to improve treatment outcomes for cancer patients, offering a promising alternative in the healthcare sector.

Fluid Biomed is a medical device start-up specializing in the development of an innovative implantable dissolving stent aimed at treating brain aneurysms. Founded by a team of neurosurgeons, the company focuses on enhancing patient outcomes by offering a bio-absorbable polymer-based flow-diverting stent that gently redirects blood flow to facilitate the healing of weakened blood vessels. This advanced medical device is designed to minimize the need for invasive procedures, allowing physicians to efficiently and effectively treat patients while reducing the risk of stroke. Through its pioneering approach, Fluid Biomed is poised to contribute significantly to the field of neurosurgery and improve the quality of care for individuals with brain aneurysms.

Nomic is a bioengineering company developing the nELISA platform for measuring proteins at scale and high throughput. They offer protein profiling solutions empowering scientists to decide experiment scope and scale.

Radiant Biotherapeutics is an innovative biotechnology company focused on developing a modular platform for multi-valent and multi-specific therapeutics. This platform aims to advance antibody engineering by creating multi-functional biologics designed to address challenging diseases, including cancer, autoimmune disorders, and infectious diseases. By leveraging the principles of avidity and enhanced binding power, Radiant Biotherapeutics enables healthcare professionals to deliver potent therapies that have the potential to transform treatment outcomes for patients. The company's commitment to pioneering these advanced therapeutics positions it at the forefront of the biotherapeutics field, striving to unlock new avenues for patient care.

Ability Biologics is a biotechnology company focused on developing innovative immune-modulating biotherapeutics aimed at addressing significant unmet medical needs in patients suffering from cancer and autoimmune diseases. The company leverages a platform that employs advanced artificial intelligence to analyze a vast database of antigen-antibody interactions. This technology enables the creation of tailored and effective antibody therapeutics designed to provide healthcare professionals with potent treatment options for conditions that currently lack adequate solutions. Through its commitment to addressing these critical health challenges, Ability Biologics seeks to enhance patient outcomes and advance the field of immunotherapy.

Reverb Therapeutics focuses on developing innovative treatments for cancer and other diseases through advanced cytokine therapy. The company specializes in using bispecific antibodies to target and localize endogenous cytokines to immune cells within the tumor microenvironment. This approach aims to enhance targeted immune activation while minimizing the toxicity commonly associated with exogenously delivered cytokines. By leveraging the body's own cytokines, Reverb Therapeutics seeks to improve treatment outcomes for cancer patients, offering a promising alternative in the healthcare sector.

Tentarix Biotherapeutics is a company focused on developing innovative protein therapeutics that address critical limitations in the treatment of cancer, autoimmune diseases, and other conditions. Utilizing a protein engineering platform, Tentarix specializes in creating multispecific binding molecules that combine unique bioactivities derived from fully human antibody variable domains. By leveraging synthetic biology, the company aims to provide clinicians with new therapeutic options that offer enhanced specificity and activity, thereby improving patient outcomes in various disease contexts.

Evommune, Inc. is a biotechnology company based in Los Altos, California, that develops and manufactures tissue-based medicines for inflammatory diseases. Incorporated in 2020, Evommune focuses on creating novel strategies to treat these disorders by addressing both symptoms and the underlying causes, thereby halting disease progression. The company employs a proprietary tissue-based platform that accelerates the discovery of innovative treatments, enhancing the potential for clinical success. With a commitment to improving the quality of life for patients, Evommune's pipeline includes initiatives aimed at tackling a range of prevalent inflammatory illnesses, positioning the company as a leader in advancing therapies in the fields of immunology and dermatology.

Radiant Biotherapeutics is an innovative biotechnology company focused on developing a modular platform for multi-valent and multi-specific therapeutics. This platform aims to advance antibody engineering by creating multi-functional biologics designed to address challenging diseases, including cancer, autoimmune disorders, and infectious diseases. By leveraging the principles of avidity and enhanced binding power, Radiant Biotherapeutics enables healthcare professionals to deliver potent therapies that have the potential to transform treatment outcomes for patients. The company's commitment to pioneering these advanced therapeutics positions it at the forefront of the biotherapeutics field, striving to unlock new avenues for patient care.

Abdera is an oncology company developing targeted alpha therapies for patients with relapsed, refractory, or metastatic cancers. Its precision oncology platform integrates drug development and antibody engineering technologies to create novel radiopharmaceuticals that specifically target tumors while minimizing systemic toxicities.

Abdera is an oncology company developing targeted alpha therapies for patients with relapsed, refractory, or metastatic cancers. Its precision oncology platform integrates drug development and antibody engineering technologies to create novel radiopharmaceuticals that specifically target tumors while minimizing systemic toxicities.

Congruence Therapeutics is a biotechnology company that integrates computational and experimental drug discovery to design novel small molecules for diseases of protein misfolding, using structural bioinformatics, computational chemistry, and machine learning to identify and optimize pharmacological stabilizers at accelerated pace and scale to correct disease pathogenesis.

DrugBank is a leading provider of pharmaceutical knowledge databases. It offers an extensive suite of products powered by the world's most comprehensive and up-to-date drug information. The company enables businesses to enhance healthcare delivery through precision medicine and clinical software applications, while also facilitating drug discovery through data science. DrugBank's structured datasets are used for uncovering novel drug candidates, identifying repurposing opportunities, and building predictive machine learning models. Additionally, DrugBank Online, a publicly available resource, offers limited datasets for academic and non-commercial researchers.

Celsius Therapeutics, Inc. is a biotechnology company focused on developing precision medicines for patients suffering from cancer and autoimmune diseases. Founded in 2018 and based in Cambridge, Massachusetts, the company employs a multidisciplinary approach, integrating the expertise of scientists, computational biologists, and clinicians. Celsius Therapeutics utilizes advanced techniques such as single-cell genomic analysis and machine learning to identify and develop innovative therapeutic solutions. By leveraging these cutting-edge technologies, the company aims to create life-changing medicines that address unmet medical needs.

Congruence Therapeutics is a biotechnology company that integrates computational and experimental drug discovery to design novel small molecules for diseases of protein misfolding, using structural bioinformatics, computational chemistry, and machine learning to identify and optimize pharmacological stabilizers at accelerated pace and scale to correct disease pathogenesis.

Gandeeva Therapeutics is a precision biotechnology company that combines cryogenic electron microscopy (cryo-EM) and machine learning to discover and develop therapeutics by targeting and modulating key protein-protein interactions. Its structure-guided drug discovery platform comprises SPOTLIGHT for target prediction and validation, HYPERFOCUS for hit identification from virtual and fragment libraries, and CRYO-CADD for lead optimization. The company pursues a preclinical oncology program focused on difficult-to-treat cancers with novel protein interaction modulators, including interfacial glues and allosteric inhibitors. Headquartered in the Greater Vancouver area of Canada, Gandeeva aims to advance differentiated therapeutics and improve outcomes for patients by leveraging its integrated imaging, modeling, and screening capabilities.

InVivo AI is a Montreal-based company founded in 2017 that specializes in leveraging artificial intelligence to enhance pharmaceutical research and development, with a particular focus on preclinical toxicology. The company has developed advanced AI methods for molecular representation, structure and ligand-based de novo design, and multiparameter optimization, enabling the creation of novel chemistry to address complex biological challenges.

Prilenia is a clinical-stage biotechnology company focused on developing innovative treatments for neurodegenerative and neurodevelopmental disorders. Founded in 2018 and operating from locations in Israel, the Netherlands, and Boston, the company’s primary asset is Pridopidine, an oral drug candidate noted for its established safety profile. Pridopidine demonstrates potential in treating various movement disorders and neurodegenerative diseases that affect both adults and children, aiming to help healthcare institutions preserve functional capacity in patients, including those undergoing early hemodialysis.

Thryv Therapeutics is a precision medicine company focused on developing innovative therapeutics for Long QT Syndrome and other arrhythmias. The company employs a precision medicine approach to address both genetic and drug-induced long QT syndrome, as well as atrial fibrillation and treatment-resistant cancers. Thryv Therapeutics specializes in creating potent and selective inhibitors of Serum Glucocorticoid Inducible Kinase, aiming to provide therapies that can significantly reduce the risk of sudden cardiac death and enhance the quality of life for patients affected by these serious conditions.

Deep Genomics is a Toronto-based company founded in 2014. It specializes in developing individualized genetic medicines using artificial intelligence systems to accelerate drug discovery and development processes, including target discovery, lead optimization, toxicity assessment, and innovative trial design. The company focuses on therapies for rare metabolic, ophthalmologic, and neurodegenerative disorders, utilizing oligonucleotide therapies that target genetic determinants of disease at the RNA or DNA level.

Giiant Pharma is a preclinical-stage biotechnology company developing gut-restricted, tissue-targeted small molecule therapeutics for gastroenterology and inflammatory bowel diseases. Leveraging a proprietary Precision Delivery platform, it uses the gut microbiota to bioactivate and release active drug forms specifically in the lower GI tract, minimizing systemic exposure and potentially improving tolerability and efficacy. The company’s lead program, GT-2108, is a microbiota-activated PDE4 inhibitor prodrug designed to reduce inflammation in the colon. By focusing on localized delivery and reduced systemic exposure, Giiant aims to provide safer, more effective treatments for IBD and related GI conditions.

Notch Therapeutics is a Toronto-based company developing immune cell therapies using induced pluripotent stem cell technology to create gene-edited allogeneic T cells. Its platform enables precise control of Notch signaling during T-cell development, enabling scalable manufacture of a uniform supply of therapeutic T cells for cancer indications such as non-Hodgkin lymphoma, leukemia, and multiple myeloma. The approach aims to overcome bottlenecks in cell therapy development by integrating advanced product design with commercially compatible processes, supporting a next-generation pipeline of cell therapies.

Deep Genomics is a Toronto-based company founded in 2014. It specializes in developing individualized genetic medicines using artificial intelligence systems to accelerate drug discovery and development processes, including target discovery, lead optimization, toxicity assessment, and innovative trial design. The company focuses on therapies for rare metabolic, ophthalmologic, and neurodegenerative disorders, utilizing oligonucleotide therapies that target genetic determinants of disease at the RNA or DNA level.

Xap Therapeutics is a biotechnology start-up based in Cambridge, England, founded in 2017 by James Patterson, M.D., Ph.D. The company is focused on developing a synthetic biology-driven platform for cell therapeutics. This platform utilizes clustered regularly interspaced short palindromic repeats (CRISPR) technology to engineer induced pluripotent stem cells, creating a foundational "chassis" cell. These chassis cells can be functionalized into various cell therapies through genetically engineered constructs. Xap Therapeutics aims to enhance treatment options for serious diseases, including autoimmunity and cancer, by leveraging its innovative approach to cell therapy development.

Milestone Pharmaceuticals is a biopharmaceutical company focused on developing and commercializing etripamil, a rapid-onset calcium channel blocker for cardiovascular conditions. The lead product is etripamil, administered as a nasal spray for self-treatment of episodes of paroxysmal supraventricular tachycardia, with ongoing Phase III studies in the United States and Canada. The company is also advancing development for other cardiovascular indications, including atrial fibrillation and angina, with a Phase II program for atrial fibrillation with rapid ventricular response. Founded in 2003, Milestone is headquartered in Montreal.

Zymeworks is a biotechnology company focused on optimizing protein-based therapeutics, particularly for cancer treatment. It uses proprietary computational methods to engineer differentiated product candidates, with its lead asset zanidatamab in multiple clinical trials targeting HER2-expressing solid tumors.

PHEMI Systems Corporation specializes in developing a comprehensive privacy, security, governance, and data management system optimized for Microsoft Azure. Founded in 2013 and based in Vancouver, Canada, the company focuses on the healthcare sector, offering the PHEMI Data Privacy Manager. This cloud-based platform addresses the critical need for healthcare organizations to secure, manage, and control access to sensitive information while ensuring compliance with privacy regulations. Built on a privacy-by-design architecture, PHEMI’s software facilitates data sharing and integrates seamlessly with numerous data sources, as well as popular data science and business analysis tools. The platform is designed to scale according to the organization's size and offers a flexible usage-based pricing model.

Shoebox develops validated iPad audiometers to help solve everyday problems faced by hearing health professionals and workplace safety managers. They offer solutions for occupational hearing testing. They offer validated online hearing screening, boothless diagnostic audiometers, and a comprehensive tele-audiology solution.

Imagia Cybernetics Inc. is a Montreal-based company that specializes in medical image analysis solutions aimed at cancer detection and management. The company focuses on early detection and quantification of cancer changes, which is crucial for improving patient outcomes. Imagia's Artificial Clinical Intelligence Platform delivers timely insights into primary tumors and metastasis, thereby personalizing the cancer care continuum for patients. Utilizing a unique approach called Deep Radiomics, which combines radiomics and deep learning, the platform analyzes routine clinical imaging data to identify robust biomarkers that can predict patient outcomes. By leveraging advancements in artificial intelligence and federated learning, Imagia enhances the capabilities of clinicians, enabling them to conduct predictive, diagnostic, and prescriptive analytics while maintaining data privacy.