ARCH Venture Partners

Aera Therapeutics is a biotechnology company focused on advancing genetic medicines through its proprietary protein nanoparticle (PNP) delivery platform. This innovative platform utilizes endogenous human proteins derived from retroelements, which self-assemble into capsid-like structures capable of packaging and transferring nucleic acid cargo. By addressing the limitations of current delivery technologies, Aera aims to enhance the efficacy and reach of genetic therapies across various tissues and disease areas. Additionally, the company holds a licensed technology that features a therapeutic enzyme platform based on novel, compact, and programmable gene-editing enzymes, further expanding its capabilities in the field of genetic medicine.

Aera Therapeutics is a biotechnology company focused on advancing genetic medicines through its proprietary protein nanoparticle (PNP) delivery platform. This innovative platform utilizes endogenous human proteins derived from retroelements, which self-assemble into capsid-like structures capable of packaging and transferring nucleic acid cargo. By addressing the limitations of current delivery technologies, Aera aims to enhance the efficacy and reach of genetic therapies across various tissues and disease areas. Additionally, the company holds a licensed technology that features a therapeutic enzyme platform based on novel, compact, and programmable gene-editing enzymes, further expanding its capabilities in the field of genetic medicine.

Nutcracker Therapeutics is a biotechnology company based in Emeryville, California, that develops and manufactures mRNA therapeutics using a proprietary microfluidic, biochip-based platform. Its ACORN system is a computer-controlled RNA manufacturing platform that starts with a nucleic acid sequence and produces optimized nanoparticle-encapsulated RNA therapeutics on dedicated single-use biochips. The company provides a push-button mRNA synthesis and formulation capability, enabling fully integrated production of mRNA therapies at scale and on demand. The platform combines advances in RNA biology with manufacturing concepts inspired by semiconductors to enable rapid discovery, development, and manufacturing of complex mRNA therapies and vaccines. By offering on-demand production and a scalable capability, Nutcracker Therapeutics aims to support healthcare teams to produce multimodal therapeutics at the point of care.

Nutcracker Therapeutics is a biotechnology company based in Emeryville, California, that develops and manufactures mRNA therapeutics using a proprietary microfluidic, biochip-based platform. Its ACORN system is a computer-controlled RNA manufacturing platform that starts with a nucleic acid sequence and produces optimized nanoparticle-encapsulated RNA therapeutics on dedicated single-use biochips. The company provides a push-button mRNA synthesis and formulation capability, enabling fully integrated production of mRNA therapies at scale and on demand. The platform combines advances in RNA biology with manufacturing concepts inspired by semiconductors to enable rapid discovery, development, and manufacturing of complex mRNA therapies and vaccines. By offering on-demand production and a scalable capability, Nutcracker Therapeutics aims to support healthcare teams to produce multimodal therapeutics at the point of care.

Glympse Bio, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in developing modular nanoparticle sensors for noninvasive diagnostics. Founded in 2015, the company focuses on creating diagnostic solutions for various diseases, including fibrosis, cancer, immunology, and infectious diseases. Utilizing a unique platform technology originally developed at MIT, Glympse Bio employs precisely engineered diagnostic agents that interrogate the body to detect specific disease states and transmit this information to urine for analysis. This innovative approach facilitates predictive monitoring and enhances the ability of physicians to assess treatment responses accurately. The company aims to transform disease monitoring and improve patient outcomes through its Glympse Inside product engine, which supports comprehensive, pan-disease diagnostics.

Glympse Bio, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in developing modular nanoparticle sensors for noninvasive diagnostics. Founded in 2015, the company focuses on creating diagnostic solutions for various diseases, including fibrosis, cancer, immunology, and infectious diseases. Utilizing a unique platform technology originally developed at MIT, Glympse Bio employs precisely engineered diagnostic agents that interrogate the body to detect specific disease states and transmit this information to urine for analysis. This innovative approach facilitates predictive monitoring and enhances the ability of physicians to assess treatment responses accurately. The company aims to transform disease monitoring and improve patient outcomes through its Glympse Inside product engine, which supports comprehensive, pan-disease diagnostics.

Siluria Technologies is a materials innovation company focused on addressing global challenges in the natural gas, chemicals, and fuel industries. By leveraging advancements in nanotechnology, biotechnology, and chemical engineering, Siluria has created a platform that enables the efficient production of chemicals and fuels from natural gas, a more abundant and cost-effective resource compared to oil. Their technology allows for the conversion of natural gas into higher-value products, including liquid fuels such as gasoline, diesel, and jet fuel, through the integration of nanomaterials and catalyst development. Siluria's research and engineering teams are actively working to commercialize their solutions and engage with major chemical and fuel companies to bring their technology to pilot-scale production.

Nanosys, Inc. is a company that specializes in the development and manufacturing of quantum dot technology aimed at enhancing high-definition viewing experiences across various display applications. Founded in 2001 and headquartered in Milpitas, California, Nanosys produces Quantum Dot Concentrate materials and Quantum Dot Enhancement films that improve the performance of a wide range of consumer electronics, including televisions, tablets, and smartphones. The company's quantum dots are nanoscale semiconductors that enable displays to achieve greater brightness and a wider color gamut, resulting in more lifelike images. This technology is compatible with various display types, including LED-LCDs, OLEDs, and micro-LEDs. Nanosys has seen significant adoption of its technology, with over 20 million devices shipped in numerous products, thus contributing to advancements in the display industry.

Siluria Technologies is a materials innovation company focused on addressing global challenges in the natural gas, chemicals, and fuel industries. By leveraging advancements in nanotechnology, biotechnology, and chemical engineering, Siluria has created a platform that enables the efficient production of chemicals and fuels from natural gas, a more abundant and cost-effective resource compared to oil. Their technology allows for the conversion of natural gas into higher-value products, including liquid fuels such as gasoline, diesel, and jet fuel, through the integration of nanomaterials and catalyst development. Siluria's research and engineering teams are actively working to commercialize their solutions and engage with major chemical and fuel companies to bring their technology to pilot-scale production.

Cambrios Technologies Corporation is a manufacturer of innovative electronic materials specializing in silver nanowire-based electrodes. Founded in 2002 and originally named Semzyme, Inc., the company rebranded in August 2004. Headquartered in Sunnyvale, California, with additional offices in Japan and Taiwan, Cambrios develops products such as ClearOhm, which are transparent conductive coatings that can be applied to various substrates for multiple applications. These include touch screens, liquid crystal displays, e-paper, OLED devices, and lighting, as well as thin film photovoltaics like organic photovoltaics and printed organic solar cells. Cambrios's technology enables simplified manufacturing processes and enhances the performance of next-generation consumer devices.

Siluria Technologies is a materials innovation company focused on addressing global challenges in the natural gas, chemicals, and fuel industries. By leveraging advancements in nanotechnology, biotechnology, and chemical engineering, Siluria has created a platform that enables the efficient production of chemicals and fuels from natural gas, a more abundant and cost-effective resource compared to oil. Their technology allows for the conversion of natural gas into higher-value products, including liquid fuels such as gasoline, diesel, and jet fuel, through the integration of nanomaterials and catalyst development. Siluria's research and engineering teams are actively working to commercialize their solutions and engage with major chemical and fuel companies to bring their technology to pilot-scale production.

Shocking Technologies, Inc. started operations as a privately held, venture-backed company developing Voltage Switchable Dielectricâ„¢ (VSDâ„¢) materials. A VSDâ„¢ material is a polymer nano-composite that behaves like an insulator (dielectric) during normal circuit operation and becomes conductive when the voltage across the VSDâ„¢ material increases beyond a predefined threshold voltage. The voltage switches back to an insulator again after the voltage drops below the threshold. This unique property, coupled with the ability to tailor the response of the material, opens up several new areas in electronics. The first application being introduced enables embedded electrostatic discharge (ESD) protection in printed circuit boards (PCBs) and semiconductor packages. Subsequent applications will usher in new manufacturing processes as well as novel product designs.

Siluria Technologies is a materials innovation company focused on addressing global challenges in the natural gas, chemicals, and fuel industries. By leveraging advancements in nanotechnology, biotechnology, and chemical engineering, Siluria has created a platform that enables the efficient production of chemicals and fuels from natural gas, a more abundant and cost-effective resource compared to oil. Their technology allows for the conversion of natural gas into higher-value products, including liquid fuels such as gasoline, diesel, and jet fuel, through the integration of nanomaterials and catalyst development. Siluria's research and engineering teams are actively working to commercialize their solutions and engage with major chemical and fuel companies to bring their technology to pilot-scale production.

BIND Therapeutics is a clinical-stage nanomedicine platform company focused on developing innovative targeted and programmable therapeutics known as Accurins. These specialized drug delivery systems are engineered with distinct physical and chemical properties to effectively target specific cells or tissues, concentrating therapeutic agents at the disease site to improve treatment efficacy while reducing adverse effects on healthy tissues. BIND's primary focus is on oncology, with its lead drug candidate, BIND-014, currently undergoing Phase 2 clinical trials for non-small cell lung cancer and metastatic castrate-resistant prostate cancer. The company also collaborates with leading biopharmaceutical firms, such as Amgen, Pfizer, and AstraZeneca, to create Accurins utilizing their therapeutic payloads. Through its medicinal nanoengineering platform, BIND Therapeutics aims to advance its own pipeline and forge strategic partnerships in the field of cancer treatment.

Shocking Technologies, Inc. started operations as a privately held, venture-backed company developing Voltage Switchable Dielectricâ„¢ (VSDâ„¢) materials. A VSDâ„¢ material is a polymer nano-composite that behaves like an insulator (dielectric) during normal circuit operation and becomes conductive when the voltage across the VSDâ„¢ material increases beyond a predefined threshold voltage. The voltage switches back to an insulator again after the voltage drops below the threshold. This unique property, coupled with the ability to tailor the response of the material, opens up several new areas in electronics. The first application being introduced enables embedded electrostatic discharge (ESD) protection in printed circuit boards (PCBs) and semiconductor packages. Subsequent applications will usher in new manufacturing processes as well as novel product designs.

Cambrios Technologies Corporation is a manufacturer of innovative electronic materials specializing in silver nanowire-based electrodes. Founded in 2002 and originally named Semzyme, Inc., the company rebranded in August 2004. Headquartered in Sunnyvale, California, with additional offices in Japan and Taiwan, Cambrios develops products such as ClearOhm, which are transparent conductive coatings that can be applied to various substrates for multiple applications. These include touch screens, liquid crystal displays, e-paper, OLED devices, and lighting, as well as thin film photovoltaics like organic photovoltaics and printed organic solar cells. Cambrios's technology enables simplified manufacturing processes and enhances the performance of next-generation consumer devices.

Shocking Technologies, Inc. started operations as a privately held, venture-backed company developing Voltage Switchable Dielectricâ„¢ (VSDâ„¢) materials. A VSDâ„¢ material is a polymer nano-composite that behaves like an insulator (dielectric) during normal circuit operation and becomes conductive when the voltage across the VSDâ„¢ material increases beyond a predefined threshold voltage. The voltage switches back to an insulator again after the voltage drops below the threshold. This unique property, coupled with the ability to tailor the response of the material, opens up several new areas in electronics. The first application being introduced enables embedded electrostatic discharge (ESD) protection in printed circuit boards (PCBs) and semiconductor packages. Subsequent applications will usher in new manufacturing processes as well as novel product designs.

BIND Therapeutics is a clinical-stage nanomedicine platform company focused on developing innovative targeted and programmable therapeutics known as Accurins. These specialized drug delivery systems are engineered with distinct physical and chemical properties to effectively target specific cells or tissues, concentrating therapeutic agents at the disease site to improve treatment efficacy while reducing adverse effects on healthy tissues. BIND's primary focus is on oncology, with its lead drug candidate, BIND-014, currently undergoing Phase 2 clinical trials for non-small cell lung cancer and metastatic castrate-resistant prostate cancer. The company also collaborates with leading biopharmaceutical firms, such as Amgen, Pfizer, and AstraZeneca, to create Accurins utilizing their therapeutic payloads. Through its medicinal nanoengineering platform, BIND Therapeutics aims to advance its own pipeline and forge strategic partnerships in the field of cancer treatment.

Shocking Technologies, Inc. started operations as a privately held, venture-backed company developing Voltage Switchable Dielectricâ„¢ (VSDâ„¢) materials. A VSDâ„¢ material is a polymer nano-composite that behaves like an insulator (dielectric) during normal circuit operation and becomes conductive when the voltage across the VSDâ„¢ material increases beyond a predefined threshold voltage. The voltage switches back to an insulator again after the voltage drops below the threshold. This unique property, coupled with the ability to tailor the response of the material, opens up several new areas in electronics. The first application being introduced enables embedded electrostatic discharge (ESD) protection in printed circuit boards (PCBs) and semiconductor packages. Subsequent applications will usher in new manufacturing processes as well as novel product designs.

Cambrios Technologies Corporation is a manufacturer of innovative electronic materials specializing in silver nanowire-based electrodes. Founded in 2002 and originally named Semzyme, Inc., the company rebranded in August 2004. Headquartered in Sunnyvale, California, with additional offices in Japan and Taiwan, Cambrios develops products such as ClearOhm, which are transparent conductive coatings that can be applied to various substrates for multiple applications. These include touch screens, liquid crystal displays, e-paper, OLED devices, and lighting, as well as thin film photovoltaics like organic photovoltaics and printed organic solar cells. Cambrios's technology enables simplified manufacturing processes and enhances the performance of next-generation consumer devices.

Cambrios Technologies Corporation is a manufacturer of innovative electronic materials specializing in silver nanowire-based electrodes. Founded in 2002 and originally named Semzyme, Inc., the company rebranded in August 2004. Headquartered in Sunnyvale, California, with additional offices in Japan and Taiwan, Cambrios develops products such as ClearOhm, which are transparent conductive coatings that can be applied to various substrates for multiple applications. These include touch screens, liquid crystal displays, e-paper, OLED devices, and lighting, as well as thin film photovoltaics like organic photovoltaics and printed organic solar cells. Cambrios's technology enables simplified manufacturing processes and enhances the performance of next-generation consumer devices.

Cambrios Technologies Corporation is a manufacturer of innovative electronic materials specializing in silver nanowire-based electrodes. Founded in 2002 and originally named Semzyme, Inc., the company rebranded in August 2004. Headquartered in Sunnyvale, California, with additional offices in Japan and Taiwan, Cambrios develops products such as ClearOhm, which are transparent conductive coatings that can be applied to various substrates for multiple applications. These include touch screens, liquid crystal displays, e-paper, OLED devices, and lighting, as well as thin film photovoltaics like organic photovoltaics and printed organic solar cells. Cambrios's technology enables simplified manufacturing processes and enhances the performance of next-generation consumer devices.

Nanosys, Inc. is a company that specializes in the development and manufacturing of quantum dot technology aimed at enhancing high-definition viewing experiences across various display applications. Founded in 2001 and headquartered in Milpitas, California, Nanosys produces Quantum Dot Concentrate materials and Quantum Dot Enhancement films that improve the performance of a wide range of consumer electronics, including televisions, tablets, and smartphones. The company's quantum dots are nanoscale semiconductors that enable displays to achieve greater brightness and a wider color gamut, resulting in more lifelike images. This technology is compatible with various display types, including LED-LCDs, OLEDs, and micro-LEDs. Nanosys has seen significant adoption of its technology, with over 20 million devices shipped in numerous products, thus contributing to advancements in the display industry.

Nanosys, Inc. is a company that specializes in the development and manufacturing of quantum dot technology aimed at enhancing high-definition viewing experiences across various display applications. Founded in 2001 and headquartered in Milpitas, California, Nanosys produces Quantum Dot Concentrate materials and Quantum Dot Enhancement films that improve the performance of a wide range of consumer electronics, including televisions, tablets, and smartphones. The company's quantum dots are nanoscale semiconductors that enable displays to achieve greater brightness and a wider color gamut, resulting in more lifelike images. This technology is compatible with various display types, including LED-LCDs, OLEDs, and micro-LEDs. Nanosys has seen significant adoption of its technology, with over 20 million devices shipped in numerous products, thus contributing to advancements in the display industry.

Nanophase Technologies Corporation develops nano-engineered materials and formulation capabilities for personal care, coatings, plastics, medical diagnostics and related applications. It produces surface-engineered zinc oxide and titanium dioxide for sunscreens and cosmetics, and offers fully formulated cosmetics under the Solésence brand. The company provides advanced materials products, including coated nanoparticles and dispersions for architectural and industrial coatings, abrasion-resistant and plastics additives, and surface finishing technologies. Headquartered in Romeoville, Illinois, it was founded in 1989 and serves customers in North America and internationally.