Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis. The company develops and markets the Saphyr system, which is a platform for ultra-sensitive and ultra-specific structural variation detection in DNA. Structural variations are alterations in the DNA structure, such as insertions, deletions, inversions, and translocations, that can be associated with various genetic disorders and diseases, including cancer. Bionano Genomics' Saphyr system uses a technology called optical genome mapping (OGM) to analyze long DNA molecules. OGM allows for the direct visualization and analysis of structural variations in the genome without the need for sequencing. This technology can provide valuable insights into the structural variations in an individual's genome, which can be important for understanding disease mechanisms, and genetic disorders, and for guiding personalized treatment strategies.
Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis. The company develops and markets the Saphyr system, which is a platform for ultra-sensitive and ultra-specific structural variation detection in DNA. Structural variations are alterations in the DNA structure, such as insertions, deletions, inversions, and translocations, that can be associated with various genetic disorders and diseases, including cancer. Bionano Genomics' Saphyr system uses a technology called optical genome mapping (OGM) to analyze long DNA molecules. OGM allows for the direct visualization and analysis of structural variations in the genome without the need for sequencing. This technology can provide valuable insights into the structural variations in an individual's genome, which can be important for understanding disease mechanisms, and genetic disorders, and for guiding personalized treatment strategies.
Micro Interventional Devices is developing disruptive technologies that are revolutionizing percutaneous and minimally invasive structural heart repair procedures. Their proprietary technology is based on a breakthrough in soft- tissue anchoring and associated delivery devices that enable off-pump procedures.
Proterro is the only company that makes sucrose instead of extracting it. Because of this, its non-crop based, noncellulosic, fermentation-ready sugar feedstock avoids the pricing volatility associated with corn and other feedstock markets, ensuring an economical and scalable production of biofuels and biobased chemicals.
Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis. The company develops and markets the Saphyr system, which is a platform for ultra-sensitive and ultra-specific structural variation detection in DNA. Structural variations are alterations in the DNA structure, such as insertions, deletions, inversions, and translocations, that can be associated with various genetic disorders and diseases, including cancer. Bionano Genomics' Saphyr system uses a technology called optical genome mapping (OGM) to analyze long DNA molecules. OGM allows for the direct visualization and analysis of structural variations in the genome without the need for sequencing. This technology can provide valuable insights into the structural variations in an individual's genome, which can be important for understanding disease mechanisms, and genetic disorders, and for guiding personalized treatment strategies.
Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis. The company develops and markets the Saphyr system, which is a platform for ultra-sensitive and ultra-specific structural variation detection in DNA. Structural variations are alterations in the DNA structure, such as insertions, deletions, inversions, and translocations, that can be associated with various genetic disorders and diseases, including cancer. Bionano Genomics' Saphyr system uses a technology called optical genome mapping (OGM) to analyze long DNA molecules. OGM allows for the direct visualization and analysis of structural variations in the genome without the need for sequencing. This technology can provide valuable insights into the structural variations in an individual's genome, which can be important for understanding disease mechanisms, and genetic disorders, and for guiding personalized treatment strategies.
Nistica is a global supplier of agile optical modules that simplify, automate and make affordable the delivery of high bandwidth applications. Founded in January 2005 with the vision of automating the edge and metro core of the optical network, Nistica has designed its products for optical system OEM vendors around the world.
Aldis, Inc., a CleanTech company, develops, commercializes, and sells traffic and energy management technology and services to municipal partners. The company offers GridSmart, a vision-based traffic monitoring and control system. Its GridSmart line of products include Spectra 360, a single-camera solution that sees in various directions; GridSmart Optima 360, which provides stop-bar detection, as well as vehicle counting, speed, and classification; GridSmart Ultra 360, which tracks vehicle speed, turn and pedestrian counts, emergency vehicle preemption modes, machine-enabled red light mitigation, and real-time video feeds; GridSmart XPress, a freeway monitoring system to view and track vehicles and provides traffic control center with vehicle counts and average speeds; and GridSmart Centrex, a smart parking system. The company also provides SmartWay, a line of products that provide energy efficient LED traffic signals. In addition, its solutions include vehicle/turn counts, red light runner (RLR) mitigation, auto alerts, pedestrian tracking, and software upgrades. The company serves transportation logistics and advanced infrastructure management markets. Aldis, Inc. was founded in 2006 and is based in Oak Ridge, Tennessee.
Nistica is a global supplier of agile optical modules that simplify, automate and make affordable the delivery of high bandwidth applications. Founded in January 2005 with the vision of automating the edge and metro core of the optical network, Nistica has designed its products for optical system OEM vendors around the world.
Hepregen Corporation is pursuing applications of its microliver platform for acute and chronic toxicity as well as for understanding the metabolism of drugs in the liver. Applications in the pharmaceutical industry may well extend beyond toxicity and metabolism to include utility in drug discovery, disease modeling (obesity, infectious disease, diabetes), in silico models, and toxicogenomics. Hepregen is actively engaged in industrial collaborations to validate the microliver platform in a wide spectrum of applications. The combined markets for Hepregen's microliver platform is approximately a billion dollars annually.
Hepregen Corporation is pursuing applications of its microliver platform for acute and chronic toxicity as well as for understanding the metabolism of drugs in the liver. Applications in the pharmaceutical industry may well extend beyond toxicity and metabolism to include utility in drug discovery, disease modeling (obesity, infectious disease, diabetes), in silico models, and toxicogenomics. Hepregen is actively engaged in industrial collaborations to validate the microliver platform in a wide spectrum of applications. The combined markets for Hepregen's microliver platform is approximately a billion dollars annually.
NuPathe Inc. is a specialty pharmaceutical company focused on innovative neuroscience solutions for diseases of the central nervous system including neurological and psychiatric disorders. NuPathe's lead product candidate, NP101, is an active, single-use, transdermal sumatriptan patch being developed for the treatment of migraine. In addition to NP101, NuPathe has two proprietary product candidates based on its LAD™, or Long-Acting Delivery, biodegradable implant technology that allows delivery of therapeutic levels of medication over a period of months with a single dose. NP201, for the continuous symptomatic treatment of Parkinson's disease, utilizes a leading FDA-approved dopamine agonist, ropinirole, and is being developed to provide up to two months of continuous delivery. NP202, for the long-term treatment of schizophrenia and bipolar disorder, is being developed to address the long-standing problem of patient noncompliance by providing three months of continuous delivery of risperidone, an atypical antipsychotic. NuPathe is actively seeking partnerships to maximize the commercial potential for its product candidates in the U.S. and territories throughout the world.
RemoteReality is the designer and manufacturer of ultra wide-angle computational cameras and video systems. Using their unique patented optics, the latest in image sensors, and their own advanced video processing, their solutions deliver high resolution real time, low latency video for a variety of cutting edge applications. Their video solutions are available in both day and night configurations, spanning the visible, LWIR and MWIR spectra.
NellOne Therapeutics is a regenerative medicine company that has been spun out of the U.S. Department of Energy's Oak Ridge National Laboratory in Oak Ridge, Tenn. Senior Staff Scientist Dr. Cymbeline Culiat in the Lab's Biosciences Division / Systems Genetics Group had identified the activity of the Nell1 gene's pathway in the formation of key mammalian tissues and organs, and Battelle Ventures founded NellOne to translate her basic science discovery into clinical applications. The company is dedicated to developing and commercializing Nell1 protein therapeutics for restoring tissue mass and function in patients recovering from heart attacks.
Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis. The company develops and markets the Saphyr system, which is a platform for ultra-sensitive and ultra-specific structural variation detection in DNA. Structural variations are alterations in the DNA structure, such as insertions, deletions, inversions, and translocations, that can be associated with various genetic disorders and diseases, including cancer. Bionano Genomics' Saphyr system uses a technology called optical genome mapping (OGM) to analyze long DNA molecules. OGM allows for the direct visualization and analysis of structural variations in the genome without the need for sequencing. This technology can provide valuable insights into the structural variations in an individual's genome, which can be important for understanding disease mechanisms, and genetic disorders, and for guiding personalized treatment strategies.
Nistica is a global supplier of agile optical modules that simplify, automate and make affordable the delivery of high bandwidth applications. Founded in January 2005 with the vision of automating the edge and metro core of the optical network, Nistica has designed its products for optical system OEM vendors around the world.
Hi-G-Tek is the developer of a new active-RFID platform for real-time monitoring and control of critical physical assets. Their company is commercializing patented technology that enables low power, cost-effective wireless solutions for monitoring, assessing and protecting high-value physical assets and sensitive materials. Their unique solutions provide unprecedented levels of real-time security and “sensing†of key assets, whether stationary or in transit, indoors or outdoors.
CDI Bioscience has developed an innovative technology for increased yield of bioproducts, manufactured in cellular systems. Genetic engineering technology is used to control the metabolism of cells, thus shifting the cell from replicative to production mode (RP Shift®). In particular, this technology has been designed for use in mammalian cells, unlocking their potential to produce proteins, peptides and enzymes. The current design of the technology can be readily translated to bacterial and yeast cellular systems for the production of commercial grade bioproducts.
Aldis, Inc., a CleanTech company, develops, commercializes, and sells traffic and energy management technology and services to municipal partners. The company offers GridSmart, a vision-based traffic monitoring and control system. Its GridSmart line of products include Spectra 360, a single-camera solution that sees in various directions; GridSmart Optima 360, which provides stop-bar detection, as well as vehicle counting, speed, and classification; GridSmart Ultra 360, which tracks vehicle speed, turn and pedestrian counts, emergency vehicle preemption modes, machine-enabled red light mitigation, and real-time video feeds; GridSmart XPress, a freeway monitoring system to view and track vehicles and provides traffic control center with vehicle counts and average speeds; and GridSmart Centrex, a smart parking system. The company also provides SmartWay, a line of products that provide energy efficient LED traffic signals. In addition, its solutions include vehicle/turn counts, red light runner (RLR) mitigation, auto alerts, pedestrian tracking, and software upgrades. The company serves transportation logistics and advanced infrastructure management markets. Aldis, Inc. was founded in 2006 and is based in Oak Ridge, Tennessee.
ypherlink, Inc. operates as an information-management-software company. It offers Harvester that automates a significant amount of the data discovery and mapping process, as well as enables organizations to understand what information is available and where field-level relationships exist between multiple data sources; Exploratory Warehouse, which provides prototyping of the data warehouse; and Integrity that enhances ongoing data quality processes. The company’s Harvester Integrator component provides data movement capabilities, including extracting, transforming, and loading (ETL) data into target applications. It serves organizations, government agencies, and systems integrators and application/tool providers. Sypherlink, Inc. was founded in 2001 and is headquartered in Dublin, Ohio.
Metatomix was founded in 2000 and describes themselves as the "semantic integration provider." Metatomix' solutions aim to link data from "existing disparate systems to create a common semantic understanding of your information across the enterprise, providing you a 360° view of your business information. As a result, business applications can leverage information that comes not just from a single product system or data store, but from across all data sources."
Superprotonic is an energy technology company established to market and commercialize the innovative solid acid fuel cell (SAFC) technology developed and patented by the company's founders at the California Institute of Technology. Solid acid fuel cells offer significant cost and performance advantages compared to other fuel cell technologies currently under development.
Endovalve develops percutaneous valve-replacement systems to treat mitral regurgitation. The company was founded by Tracy S. Warren and is based in Princeton, New Jersey.
RemoteReality is the designer and manufacturer of ultra wide-angle computational cameras and video systems. Using their unique patented optics, the latest in image sensors, and their own advanced video processing, their solutions deliver high resolution real time, low latency video for a variety of cutting edge applications. Their video solutions are available in both day and night configurations, spanning the visible, LWIR and MWIR spectra.
Hi-G-Tek is the developer of a new active-RFID platform for real-time monitoring and control of critical physical assets. Their company is commercializing patented technology that enables low power, cost-effective wireless solutions for monitoring, assessing and protecting high-value physical assets and sensitive materials. Their unique solutions provide unprecedented levels of real-time security and “sensing†of key assets, whether stationary or in transit, indoors or outdoors.
Rajant Corporation has developed wireless broadband systems and components that have multiple applications in homeland security, public safety, security and enterprise networking sectors. Rajant Corporation's wireless LAN systems are portable, mobile, battery powered, self-integrating, self-meshing, self-healing, secure, 802.11 access points.
BioVigilant Systems invented instantaneous microbial detection technology to address environmental monitoring needs in pharmaceutical, biotechnology, healthcare, and environmental applications. BioVigilant’s IMD systems detect—instantaneously and in real time—particulate count, size, and biological status. Unlike other rapid microbial methods, BioVigilant’s optically-based systems require no staining, no reagents, no waiting period, and little human intervention.
Private Equity Round in 2006
Metatomix was founded in 2000 and describes themselves as the "semantic integration provider." Metatomix' solutions aim to link data from "existing disparate systems to create a common semantic understanding of your information across the enterprise, providing you a 360° view of your business information. As a result, business applications can leverage information that comes not just from a single product system or data store, but from across all data sources."
Endovalve develops percutaneous valve-replacement systems to treat mitral regurgitation. The company was founded by Tracy S. Warren and is based in Princeton, New Jersey.
Multispectral Imaging, Inc. designs, develops, manufactures, and supplies infrared imaging detectors and arrays. The company provides technologies for night vision and thermal-imaging products. Its solutions include infrared imaging array detector modules that use microelectromechanical sensor and ROIC technologies to produce detectors with sensitivities; and microcantilever detector technologies, which enable detector sensitivities to the infrared detection approach. The company was founded in 2003 and is based in Parsippany, New Jersey with a branch office in Oak Ridge, Tennessee. As of April 4, 2008, Multispectral Imaging, Inc. operates as a subsidiary of Agiltron, Inc.
SmartSynch is a Smart Grid Technology Company enabling utilities to communicate with any device on the grid. The company's clean-tech innovations in the two-way delivery of real-time energy usage data over public wireless networks (AT&T, Rogers, T-Mobile, etc.), in lieu of private network build-outs, have simplified SmartMeter deployments for over 100 major North American electric utilities. Smart Grid Infrastructure A smart grid infrastructure is the sum of services, devices and software necessary to add a layer of intelligence onto today’s 20th-century electricity grid such that every point on that grid can talk to every other point and decisions are made either by devices or human beings to fully optimize the process by which electricity is generated and delivered to customers. A smart grid infrastructure can spot and stop energy “leaks,†optimize efficiency through better power factors and provide feedback loops that provide the right price signals to normalize energy loads during peak use. According to the Pacific Northwest Laboratory in partnership with the Department of Energy, the total potential benefit of implementing smart grid technologies over the next 20 years is conservatively estimated to have a present value of $75 billion. Vision SmartSynch creates extraordinary value for our customers by providing innovative Smart Grid Infrastructure solutions that leverage public wireless networks.
ypherlink, Inc. operates as an information-management-software company. It offers Harvester that automates a significant amount of the data discovery and mapping process, as well as enables organizations to understand what information is available and where field-level relationships exist between multiple data sources; Exploratory Warehouse, which provides prototyping of the data warehouse; and Integrity that enhances ongoing data quality processes. The company’s Harvester Integrator component provides data movement capabilities, including extracting, transforming, and loading (ETL) data into target applications. It serves organizations, government agencies, and systems integrators and application/tool providers. Sypherlink, Inc. was founded in 2001 and is headquartered in Dublin, Ohio.
Ventaira Pharmaceuticals is an emerging specialty pharmaceutical company focused on the development of new inhalation products by utilizing its novel proprietary electrohydrodynamic (EHD) aerosolization and formulation technologies.
Safe-View, Inc was created to bring an existing patented Holographic Imaging technology developed by PNNL (Pacific Northwest National Laboratory) to market as a commercial application. The product uses an active millimeter wave technology that is safe and offers clear resolution of hidden items. Unlike some other methods of detection the Guardian 100 allows the operator to clearly see metal, plastic, ceramic and other materials that may be hidden under clothing without using ionizing radiation. It offers a clear alternative to metal detectors, pat down searches, and other threat detection methods currently being used to ensure safety in public areas.