Bellus Health
BELLUS Health is focused on developing drugs for rare diseases, starting with conditions that affect the kidneys. The lead program KIACTA™, a novel drug candidate, is in data review after announcing on June 20, 2016 top-line results from its Phase 3 study for the treatment of AA amyloidosis, a rare disease resulting in renal dysfunction that often leads to dialysis and death. BELLUS Health is partnered with global private equity firm Auven Therapeutics for the development of KIACTA™. KIACTA™ is also being developed as a treatment in a second indication called sarcoidosis, a rare, potentially fatal inflammatory condition that affects the lungs. An investigational new drug application (IND) for a Phase 2/3 clinical study is expected to be filed with the U.S. Food and Drug Administration in 2016. In addition, BELLUS Health is developing Shigamab™, an antibody treatment for Hemolytic Uremic Syndrome caused by Shiga toxin-producing E. coli (sHUS). sHUS often leads to dialysis, chronic kidney disease and in some cases death, particularly in children. Shigamab™ pre-clinical studies for the treatment of sHUS are currently underway. BELLUS Health’s pipeline also includes a research-stage project for the treatment of AL amyloidosis, a rare disease in which amyloid protein builds up and causes dysfunction in various parts of the body.
Thallion Pharmaceuticals Inc. is a biotechnology company focused on developing new pharmaceutical products in the areas of infectious disease and oncology, with a current emphasis on developing a treatment for Shigatoxin-producing E. coli (STEC) bacterial infections. The Company's leading product candidate is Shigamabs®, a dual antibody product for the treatment of Shigatoxin-producing E. coli (STEC) bacterial infections. Thallion has completed four Phase I clinical trials evaluating the safety of Shigamabs®, which demonstrated that the antibodies are safe and well tolerated when administered both individually and in combination. In February, 2010, Thallion signed a definitive development and license agreement with Laboratoire français du Fractionnement et des Biotechnologies (LFB) for payments of up to €95 million, including a €1.5 million upfront payment. LFB received commercial rights to Shigamabs® for Europe, South America and other territories of strategic interest to LFB, including Russia, Turkey, China, South Korea and Northern African countries, while Thallion retained the rights for North America and the rest of world. The Company initiated a Phase II clinical trial in South America in November 2010 to evaluate Shigamabs® as a treatment for STEC infections. The study will comprise up to 17 clinical sites in Argentina, Chile and Peru.
Innodia is a privately held biopharmaceutical company with the mission of developing and bringing new drugs.
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