Big Brain Holdings

Founded in 2021, Big Brain Holdings is a venture capital firm based in Los Angeles, California. It focuses on investing in early-stage companies operating in the blockchain, fintech, and web3 sectors.

Jorge Cantera

Investor

Thomas Helm

Venture Partner

Sam Kim

General Partner

Kavita Singh

Analyst

Tom Weber

Analyst

Jonathan Wong

Analyst

Past deals in Infrastructure

Arch

Series A in 2025
Arch is a Blockchain Infrastructure Premier Bitcoin-Native Application Platform

Fortytwo

Pre Seed Round in 2025
Fortytwo operates a decentralized AI network that harnesses swarm intelligence by connecting consumer devices to run small AI models. This approach offers a scalable and cost-efficient alternative to traditional centralized AI systems, enabling users to contribute their computing resources while maintaining data privacy. The company aims to create a community-driven, planetary-scale reasoning engine.

ZAR

Seed Round in 2024
ZAR is a company that bridges the gap between cash-based economies and web3, hastening stablecoin adoption for those who require it most.

Octra

Pre Seed Round in 2024
Octra is a technology company specializing in blockchain infrastructure. It has developed a platform that enables secure and private computations on encrypted data without the need for decryption. This is achieved through a decentralized network of nodes, ensuring data processing and distribution without reliance on a central authority. The platform allows businesses and developers to perform complex mathematical operations on encrypted data, safeguarding the underlying information.

Soulbound

Seed Round in 2024
Soulbound is a decentralized gaming platform and community focused on expanding the metaverse through a chain-agnostic market infrastructure. It connects guilds, gamers, and game developers, rewards gameplay, and drives engagement with play-to-earn mechanics to enable blockchain-based gaming experiences across ecosystems.

Essential

Series A in 2024
Essential develops intent-based infrastructure and tools aimed at facilitating the shift from value extraction to intent satisfaction. Its platform focuses on creating core components that support composability across ecosystems, minimizing extractive behaviors while maximizing user satisfaction.

Eywa

Seed Round in 2024
Eywa is a decentralized cross-chain protocol designed to facilitate the transfer of liquidity and data across various blockchains that support smart contracts. By addressing interoperability challenges, Eywa aims to create a seamless ecosystem for decentralized finance (DeFi) applications. The protocol serves as a middle layer, enabling developers to build cross-chain decentralized applications and engage in cross-chain farming. This functionality allows users to easily perform cross-chain swaps and bridge assets across different DeFi platforms. Eywa's approach enhances the accessibility and utility of existing DeFi blockchains, fostering innovation and collaboration within the cryptocurrency space.

Zkasino

Series A in 2024
ZKasino is a technology company that specializes in developing decentralized gambling platforms for online gaming. Its core product is a hyperchain infrastructure layer designed for on-chain gaming, which allows users to bet directly using their cryptocurrency wallets, eliminating the need for traditional processes such as Know Your Customer (KYC) procedures, user sign-ups, and deposits or withdrawals. This platform enables seamless, intermediary-free online betting experiences.

Obscuro Labs

Venture Round in 2024
Obscuro Labs develops TEN, a Layer 2 rollup that scales and encrypts Ethereum, allowing smart contracts to contain both public and private elements without changing the user or developer experience. The TEN protocol operates contracts at larger scale and supports on-chain gaming, smart contract sharing, sealed token auctions, data encryption, and the deployment of tokenized rewards, while also enabling components such as artificial intelligence agents to function within the ecosystem.

Initia Labs

Seed Round in 2024
Initia is a network for 0-to-1 omnichain rollups built by fusing a novel L1 with an interwoven application-specific L2 infrastructure system. The Initia Platform provides product ready rollups that enables teams to build scalable and sovereign systems while eliminating the UX complexities end users face when interacting with a modular multi-chain universe. Initia’s ownership of the full tech stack allows for a suite of chain-level mechanisms that align the economic interests across users, developers, L2 app chains, and the L1. Initia's initial launch products include an all-in-one portal for accessing core tools of the ecosystem, a Omnitia-ecosystem focused wallet for navigating between the L2s, a block explorer that supports InitiaVM transactions and developer tooling, and a Market Minitia that allows users to trade NFTs and create AI-generated NFT collections through prompts.

Glif

Seed Round in 2024
Glif is a technology company that develops and maintains essential applications for the Filecoin ecosystem. It offers a decentralized protocol that provides tools for managing and upgrading custom staking pools, enabling users to earn yield on their assets and efficiently allocate capital and storage resources.

Nillion

Seed Round in 2022
Nillion is a computer and network security company that operates a decentralized public network based on a cryptographic primitive called Nil Message Compute (NMC). It develops a decentralized computing platform for secure processing and storage of high-value data, employing privacy technologies to enable confidential computations on masked data. The platform is designed to help healthcare and finance industries manage sensitive information while maintaining robust security standards and operational efficiency.

Spice Finance

Venture Round in 2022
Spice Finance is a financial services company that focuses on enhancing the efficiency of non-fungible token (NFT) lending markets. The company has developed a liquidity deployment infrastructure designed to optimize yields and facilitate liquidity routing. Its platform enables lenders to passively allocate capital to NFT lending marketplaces, simplifying the lending process that is often complex and time-consuming. By aggregating outstanding loans, Spice Finance provides users with the ability to create straightforward and transparent vaults that generate yields from NFT lending, thereby streamlining access to this emerging financial landscape.

New Computer Corporation

Seed Round in 2022
New Computer Corporation specializes in providing a web hosting and domain registration platform designed to offer reliable and affordable hosting services for businesses and individuals globally. The company’s offerings include a comprehensive suite of hosting solutions, such as shared hosting, VPS hosting, and dedicated hosting, alongside domain registration and various web-related services. This enables customers to easily create and manage their online presence. Moreover, New Computer Corporation integrates an application program interface for web3 infrastructure, blending emerging media, innovative technology, and product design to enhance digital marketing efforts.

SithSwap

Seed Round in 2022
SithSwap is a company that operates an advanced Automated Market Maker (AMM) on the StarkNet platform. It specializes in providing instant swaps for both volatile and stable assets with minimal slippage and near-zero fees. The company's services are designed to offer trading pairs similar to Uniswap V2, with configurable trading fees and no administrative fees. Additionally, SithSwap incorporates built-in flash loan capabilities and leverages the full security of Ethereum, allowing traders to earn incentives for participating in governance decisions regarding future protocol emissions.

Gora

Seed Round in 2022
Gora operates a decentralized oracle network platform that connects the Algorand blockchain with real-world data. Its infrastructure accelerates decentralized application development by securely integrating off-chain data with smart contracts.

Wayru

Seed Round in 2022
Wayru is a technology company that develops decentralized internet networks, focusing on providing affordable and reliable connectivity to users in Latin America. Its innovative blockchain-based system enables individuals to set up nodes using off-the-shelf Wi-Fi hardware, allowing nearby users to connect and earn rewards for each connected user. This model encourages network expansion by incentivizing node operators to invite more people, ultimately increasing internet access coverage in the region.

Eywa

Seed Round in 2022
Eywa is a decentralized cross-chain protocol designed to facilitate the transfer of liquidity and data across various blockchains that support smart contracts. By addressing interoperability challenges, Eywa aims to create a seamless ecosystem for decentralized finance (DeFi) applications. The protocol serves as a middle layer, enabling developers to build cross-chain decentralized applications and engage in cross-chain farming. This functionality allows users to easily perform cross-chain swaps and bridge assets across different DeFi platforms. Eywa's approach enhances the accessibility and utility of existing DeFi blockchains, fostering innovation and collaboration within the cryptocurrency space.

Entangle Protocol

Venture Round in 2022
Entangle is a developer of a cross-chain decentralized finance (DeFi) protocol that focuses on enhancing liquidity provision and yield access through the use of synthetic assets. The platform enables connections between Ethereum virtual machine and non-Ethereum virtual machine chains, facilitating seamless interactions across different blockchain ecosystems. By employing a messaging layer to replicate states, Entangle aims to improve liquidity retention through various utility mechanisms. This allows users to borrow against their synthetic collateral in native stablecoins, thereby increasing the overall efficiency and accessibility of liquidity in the DeFi space.

Attarius Network

Pre Seed Round in 2021
Attarius Network is a decentralized infrastructure company that provides an all-in-one toolkit for game developers, players, and NFT creators to tokenize and manage in-game assets on web3. The platform includes a native blockchain, a unified payments system, NFT integration, and DeFi modules to enable decentralized tooling for game developers pursuing asset tokenization and blockchain features. It supports cross-chain functionality, using NEAR as a core network to facilitate fast, low-cost transfers of game assets and cross-chain wallets, with an emphasis on bridging proof-of-concept projects to successful launches. By offering APIs such as a multichain game API and an authorization interface, Attarius aims to simplify the development and launch of web3 gaming projects, providing flexibility to transfer assets across networks while maintaining liquidity. The company focuses on reducing complexity for developers and enabling scalable, blockchain-enabled gaming ecosystems.

New Computer Corporation

Private Equity Round in 2020
New Computer Corporation specializes in providing a web hosting and domain registration platform designed to offer reliable and affordable hosting services for businesses and individuals globally. The company’s offerings include a comprehensive suite of hosting solutions, such as shared hosting, VPS hosting, and dedicated hosting, alongside domain registration and various web-related services. This enables customers to easily create and manage their online presence. Moreover, New Computer Corporation integrates an application program interface for web3 infrastructure, blending emerging media, innovative technology, and product design to enhance digital marketing efforts.
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