Boehringer Ingelheim

DiogenX is a preclinical stage biotechnology company based in Marseille, France, with additional research facilities in Nice. Founded in 2019, DiogenX specializes in developing pancreatic beta-cell modulators aimed at treating Type 1 and Type 2 diabetes. The company's primary focus is on creating a candidate molecule that regenerates pancreatic insulin-producing cells in diabetic patients, which has the potential to improve both quality of life and survival rates. This innovative approach to therapy was initially discovered in the laboratory of Dr. Patrick Collombat at Inserm, CNRS, and Nice University, positioning DiogenX as a pioneer in beta-cell regeneration for diabetes treatment.

C-mo Medical Solutions specializes in developing monitoring devices aimed at providing a comprehensive assessment of cough patterns in patients. The company's portable and ergonomic wearables facilitate long monitoring periods and the detection of distinctive cough patterns. With fully automated analysis capabilities, these devices enable healthcare professionals to deliver accurate diagnoses and prescribe personalized treatment plans. By addressing key use-cases throughout the patient management lifecycle, C-mo Medical Solutions plays a significant role in enhancing cough-related healthcare.

ArrePath is a company focused on discovering anti-infective drugs to tackle the global issue of drug-resistant infections. It operates a drug discovery platform that aims to develop therapies specifically targeting antimicrobial resistance. The platform is designed to create new medicines that address multiple targets within disease pathways, which may enhance treatment efficacy while minimizing risks during the discovery and development phases. This approach supports healthcare professionals in treating chronic infections and improving patient recovery times.

Centauri Therapeutics is a UK-based biotechnology company dedicated to discovering and developing innovative molecules aimed at combating life-threatening diseases. The company utilizes its proprietary Alphamer technology, which involves chemically synthesized molecules that redirect naturally occurring antibodies to specific pathogens, enhancing the immune response against infections. Each Alphamer consists of two components: one binds to a cell-surface target on the pathogen, while the other presents specific epitopes that engage circulating antibodies. This approach has demonstrated the ability to trigger an immediate antibacterial immune response, effectively clearing infections. Centauri Therapeutics' flexible Chemistry Platform allows for the synthesis of these bifunctional molecules, which are applicable in treating various infectious diseases. Additionally, the company has formed a joint venture, Avvinity Therapeutics, with Horizon Discovery to advance immuno-oncology initiatives, combining Centauri's expertise in Alphamer technology with Horizon's capabilities in gene editing and oncology. Through collaborations in aptamer selection, drug discovery, chemistry, and immunology, Centauri Therapeutics aims to enhance its impact in the field of immunotherapy.

Since launching as a spin-out from the University of Oxford in 2010, Brainomix has developed award-winning, AI-powered imaging biomarkers, assisting physicians across the world to make better life-saving decisions. Brainomix seminal product, e-Stroke is a collection of tools that use state-of-the-art AI algorithms to support doctors by providing real-time interpretation of brain scans to help guide treatment and transfer decisions for stroke patients, allowing more patients to get the right treatment, in the right place, at the right time.

OncoMyx Therapeutics, Inc. is a biotechnology company specializing in the development of oncolytic immunotherapies utilizing the myxoma virus (MYXV) to stimulate immune responses against cancer. Founded in 2018 and based in Phoenix, Arizona, the company focuses on targeting both hematologic and solid tumors through its innovative MYXV platform. This platform employs a novel systemic delivery method that allows the myxoma virus to be carried by human leukocytes, enabling it to effectively infect tumor cells. By assembling a highly skilled team in oncolytic virus research, OncoMyx aims to advance a pipeline of therapeutic options designed to improve outcomes for cancer patients.

OncoMyx Therapeutics, Inc. is a biotechnology company specializing in the development of oncolytic immunotherapies utilizing the myxoma virus (MYXV) to stimulate immune responses against cancer. Founded in 2018 and based in Phoenix, Arizona, the company focuses on targeting both hematologic and solid tumors through its innovative MYXV platform. This platform employs a novel systemic delivery method that allows the myxoma virus to be carried by human leukocytes, enabling it to effectively infect tumor cells. By assembling a highly skilled team in oncolytic virus research, OncoMyx aims to advance a pipeline of therapeutic options designed to improve outcomes for cancer patients.

Operator of a pioneering private biotech company intended for vivo direct cell reprogramming for cancer immunotherapy. The company's proprietary reprogramming technologies develop gene therapy products that ignite efficient and personalized immune responses to establish a robust pipeline of off-the-shelf cancer immunotherapies, activating personalized anti-cancer immune defenses for the benefit of patients in need by offering new treatment avenues for cancers resistant to conventional methods, enabling patients to acquire new forms of treatment for cancer resistant to conventional treatment methods.

Optina Diagnostics Inc. is a Canadian company based in Montréal, established in 2010, that focuses on the early detection of Alzheimer’s disease through advanced ocular imaging technology. The company has developed a retinal imaging test that utilizes hyperspectral imaging to identify key biomarkers associated with Alzheimer’s, including beta-amyloid plaques. In addition to Alzheimer’s detection, its imaging systems also aid in diagnosing age-related macular degeneration and ocular diabetic retinopathy. By providing a simple eye exam, Optina's technology enables healthcare professionals to detect and address the underlying causes of memory loss, thereby contributing to improved patient care and outcomes in neurodegenerative diseases.

Abalos Therapeutics GmbH is a biotechnology company based in Essen, Germany, focused on developing innovative immuno-oncology therapeutics. Founded in 2019, the company specializes in arenavirus-based drug candidates aimed at stimulating immune responses to target primary tumors and metastases. Utilizing its proprietary Fast Evolution platform, Abalos Therapeutics generates virus strains with optimized anti-tumoral properties. The company's approach involves reprogramming the immune system to effectively identify and eliminate malignant tumor tissue, thereby offering potential new treatment options for cancer. Through its novel immuno-virotherapy, Abalos Therapeutics seeks to harness the full capabilities of the immune system specifically against cancer cells.

Abexxa Biologics Inc. is a biotechnology company founded in 2015 and based in Arlington, Texas. It specializes in the discovery and development of innovative antibody-based drugs aimed at transforming cancer treatment. Abexxa's mission centers on creating targeted therapies that leverage the body's immune system to effectively combat tumors. The company focuses on developing breakthrough biopharmaceutical products that promise to enhance cancer care and improve patient outcomes.

Topas Therapeutics GmbH is a biotechnology company based in Hamburg, Germany, focused on developing nanoparticle-based therapeutics to address significant unmet medical needs, particularly in autoimmune diseases, allergies, and anti-drug antibodies. The company utilizes its proprietary Topas Particle Conjugates technology platform to induce antigen-specific immune tolerance by leveraging the liver's natural immunological processes. This approach targets liver sinusoidal endothelial cells to promote tolerance against blood-borne antigens. Topas is advancing several clinical-stage programs, with its lead candidate, TPM203, currently in clinical testing for pemphigus vulgaris, an orphan disease. Other therapeutic programs under development include treatments for celiac disease, Type 1 diabetes, and multiple sclerosis. The company has established research collaborations with Eli Lilly and Company and Boehringer Ingelheim to enhance its capabilities in antigen-specific tolerance induction and anti-drug antibodies, respectively. Topas Therapeutics was incorporated in 2013 and is dedicated to finding innovative solutions for chronic immunological conditions.

Dopavision GmbH, founded in 2017 and based in Berlin, Germany, focuses on developing a digital therapeutic for myopia, or shortsightedness, a common visual condition affecting around one in three individuals globally. The company aims to create a clinically validated therapy to slow the progression of myopia in children and adolescents. Its innovative technology employs light stimulation targeting specific photosensitive cells in the retina, which modulates dopamine levels—a neurotransmitter that plays a crucial role in eye growth regulation. This digital therapeutic can be seamlessly integrated with smartphone use, making it an accessible solution for health professionals treating myopia. Dopavision is also supported by the German government through the "Industrie-in-Klinik" program, receiving €1.4 million over three years to advance its research and development efforts.

xCures, Inc. is a company based in Los Altos, California, founded in 2018, that focuses on enhancing cancer treatment through an AI-based precision oncology platform. This platform addresses the shortcomings of traditional drug-centric approaches by integrating cancer research and clinical care, running a perpetual trial that captures Real World Evidence (RWE). By continuously learning from patient data across various treatments, xCures coordinates treatment recommendations tailored to individual needs. The software supports advanced cancer patients and their healthcare providers by structuring insights from tumor boards and utilizing machine learning to identify the most effective treatment options. Ultimately, xCures aims to reduce the time and cost associated with drug development, thereby improving patient outcomes in oncology.

Nuevocor is a preclinical-stage biopharmaceutical company dedicated to the development of gene therapy-based treatments aimed at restoring cardiac function in patients with cardiovascular diseases. The company's research focuses on genetic cardiomyopathies that involve abnormal mechanobiology. By modulating mechanical force transduction, Nuevocor's innovative approaches seek to address the underlying mechanisms of these diseases, ultimately enabling healthcare providers to improve cardiac function in affected individuals.

Rinri Therapeutics is a provider of private biotechnology services intended to develop advanced regenerative stem cell-based therapies for the treatment of hearing loss. The company's stem cell technology replaces damaged or dead sensory cells of the inner ear, enabling doctors to restore hearing of patients.

Developer of synthetic biology vaccination technology. The company's vaccine technology aims to provide solutions for antimicrobial resistant infections by improving upon traditional vaccine research, enabling healthcare providers to deliver more effective treatments to patients.

AgomAb is developing molecular therapies for the regeneration of damaged tissues. Their unique agonistic monoclonal antibody molecules (“agomAbs”) stimulate molecular and cellular repair mechanisms that have the potential to restore organ function in patients with fibrotic, inflammatory, autoimmune and degenerative diseases.

NBE-Therapeutics GmbH is a privately owned biotechnology company based in Basel, Switzerland, founded in 2012. The company specializes in the development of antibody-drug conjugates (ADCs) aimed at enhancing cancer treatment options. NBE-Therapeutics focuses on creating immune-stimulatory therapies through its proprietary ADC platform, which utilizes a unique anthracycline payload. This innovative approach not only targets tumor cells directly but also aims to induce a durable immunological response against tumors. By developing these advanced therapies, NBE-Therapeutics seeks to improve survival rates and enhance the quality of life for cancer patients globally.

LABOR DR. MERK & KOLLEGEN GMBH was founded in 1971 with the goal of developing and producing high quality diagnostics for medical use. Over the years, they gained extensive knowledge in biotechnology, virology, microbiology and toxicology and provide this know-how to external parties. They hold excellent expertise in biosafety testing of products from pharmaceutical industries or medical device manufacturers. Especially in the fields of virological and microbiological testing a wide range of GMP and GLP compliant methods for preclinical studies or quality control of final products are available. Our highly qualified and experienced team will provide personal consultation during study design and test performance, and they guarantee an economical and reliable solution to our customers’ needs.

Perfood is a digital therapeutic startup that identifies what actions need to take on a personalized level, to prevent or fight diseases. Using sensors, lab results, and holistic analyses, they derive therapeutic angles and deliver them in a slick, easy-to-use way, making them accessible for all patients. They call this approach digital therapeutics. A digital solution that is just as effective as a drug. But without side effects.

Topas Therapeutics GmbH is a biotechnology company based in Hamburg, Germany, focused on developing nanoparticle-based therapeutics to address significant unmet medical needs, particularly in autoimmune diseases, allergies, and anti-drug antibodies. The company utilizes its proprietary Topas Particle Conjugates technology platform to induce antigen-specific immune tolerance by leveraging the liver's natural immunological processes. This approach targets liver sinusoidal endothelial cells to promote tolerance against blood-borne antigens. Topas is advancing several clinical-stage programs, with its lead candidate, TPM203, currently in clinical testing for pemphigus vulgaris, an orphan disease. Other therapeutic programs under development include treatments for celiac disease, Type 1 diabetes, and multiple sclerosis. The company has established research collaborations with Eli Lilly and Company and Boehringer Ingelheim to enhance its capabilities in antigen-specific tolerance induction and anti-drug antibodies, respectively. Topas Therapeutics was incorporated in 2013 and is dedicated to finding innovative solutions for chronic immunological conditions.

Ruipeng Pet Hospital, located in Shenzhen, specializes in a comprehensive range of pet care services. The hospital provides medical and beauty care for pets, including healthcare, foster care, bathing, SPA treatments, grooming, food, and entertainment. By offering both digital and clinical services, Ruipeng aims to ensure that pet owners can access high-quality care for their animals efficiently. The organization also includes online shopping options to further support pet owners in meeting their pets' needs.

Libra Therapeutics, Inc. operates as a biotechnology company that develops novel disease-modifying therapeutics and drug candidates for restoring the cellular balance disrupted in neurodegenerative diseases. The company’s therapeutic platform discovers and develops small molecule drugs to attenuate the production of neurotoxic proteins for the treatment of amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's, Parkinson's, and Huntington's disease. The company was founded in 2019 and is based in San Diego, California.

Click Therapeutics, Inc. specializes in the engineering, validation, development, and commercialization of digital therapeutic solutions aimed at addressing unmet medical needs through cognitive and neurobehavioral modification. Founded in 2012 and based in New York, the company offers innovative digital therapeutics for a range of conditions, including smoking cessation, major depressive disorder, schizophrenia, insomnia, and chronic pain. Its Digital Therapeutics™ are designed to function independently or alongside traditional biomedical treatments, utilizing the Clickometrics® adaptive data science platform to personalize user experiences and enhance engagement. Notably, Click's smoking cessation program has gained widespread access through various payers and providers, while its primary prescription program is advancing into a significant phase III clinical trial for major depressive disorder in adults.

Aignostics GmbH, founded in 2018 and based in Berlin, Germany, specializes in AI-powered diagnostics and pathology software solutions aimed at enhancing pharmaceutical research and clinical diagnostics. The company focuses on precision diagnostics by utilizing its patented technology to provide explainable AI that addresses the limitations of traditional AI systems. Aignostics' platform generates precise heatmaps and image overlays that facilitate the interpretation of diagnostic results, allowing pathologists to quickly verify findings. This capability is essential for ensuring accurate diagnoses, particularly in the context of drug development and the discovery of tissue-based biomarkers for complex diseases like cancer. By improving the understanding of pathology, Aignostics supports more effective diagnoses and treatments in the medical field.

Bodyport Inc. is a San Francisco-based company that develops sensor-equipped weighing scales specifically designed for cardiac patients. The company's flagship product, a biomarker-driven virtual clinic, focuses on the prevention and management of heart disease. Utilizing proprietary sensor technology, Bodyport's device measures various health indicators, including blood pressure, heart rate, heart rate variability, and arterial stiffness, all through a user-friendly platform that analyzes signals from the feet. This innovative approach enables healthcare teams to assess patients' overall health, identify early signs of cardiovascular disease, and enhance interventions to prevent hospitalizations and improve quality of life. In addition to its medical devices, Bodyport offers an online patient portal and educational resources to support patients in managing their cardiovascular health. The company was established in 2015.

T-knife is a biotechnology company focused on developing T cell receptor therapies aimed at treating cancer. Utilizing a humanized T cell receptor (TCR) mice platform, the company is capable of carrying human TCRαβ gene loci and recombining a diverse array of human TCRs. This innovative approach facilitates the efficient generation and virtual selection of T cell receptors tailored for specific human tumor antigens, enhancing the potential for effective cancer therapies. Through its advanced technology, T-knife aims to improve treatment options for patients battling cancer.

Operator of a biotechnology company intended to develop innovative therapies against cancer and other life-threatening diseases. The company uses molecular glue degraders that eliminate the disease-causing protein instead of inhibiting a harmful protein's function by reprogramming the natural protein recycling machinery present in every cell, enabling physicians to change the way incurable diseases are treated.

Global Stem Cell Technology is a veterinary biotech company specializing in the development and production of advanced stem cell products for horses and dogs. The company focuses on blood-derived mesenchymal stem cells, which are intended for clinical applications in animals. By translating regenerative medicine into practical treatments, Global Stem Cell Technology aims to enhance animal welfare and improve the quality of care available for these animals.

T3 Pharmaceuticals AG is a biopharmaceutical company based in Basel, Switzerland, founded in 2015. The company focuses on the research and development of bacteria-based therapies specifically designed for cancer treatment. Recognizing the ongoing need for innovative solutions in oncology, T3 Pharmaceuticals aims to enhance the lives of cancer patients by creating highly specific and efficient treatments using live bacteria. Through its work, the company seeks to address the limitations of conventional therapies and contribute to the advancement of novel cancer medicines.

eTheRNA immunotherapies NV specializes in the development of mRNA-based immunotherapies aimed at enhancing the human immune system's response to cancer and infectious diseases. The company's innovative TriMix technology specifically targets dendritic cells, which play a crucial role in initiating immune responses. By harnessing this technology, eTheRNA seeks to provide more effective and safer treatment options for patients with conditions such as melanoma and triple-negative breast cancer. Founded in 2013 and headquartered in Niel, Belgium, eTheRNA has established a strategic partnership with China Grand Pharmaceutical and Healthcare Holdings Limited to further its research and development efforts. The company is dedicated to advancing the field of immunotherapy to improve patient outcomes.

DiogenX is a preclinical stage biotechnology company based in Marseille, France, with additional research facilities in Nice. Founded in 2019, DiogenX specializes in developing pancreatic beta-cell modulators aimed at treating Type 1 and Type 2 diabetes. The company's primary focus is on creating a candidate molecule that regenerates pancreatic insulin-producing cells in diabetic patients, which has the potential to improve both quality of life and survival rates. This innovative approach to therapy was initially discovered in the laboratory of Dr. Patrick Collombat at Inserm, CNRS, and Nice University, positioning DiogenX as a pioneer in beta-cell regeneration for diabetes treatment.

Northern Biologics Inc. is an early-stage biologics company focused on developing antibody-based therapeutics for oncology and fibrosis. Founded in 2014 and based in Toronto, Canada, the company utilizes a cutting-edge phage display platform for antibody discovery, which has been developed by leading researchers at the University of Toronto. Northern Biologics aims to address novel and challenging targets by creating innovative functional modulators of key signaling pathways involved in cancer and fibrosis. The company has established a strategic collaboration with Celgene Corporation and operates as a subsidiary of Boehringer Ingelheim International GmbH as of May 2020.

Wellth develops and operates a mobile application to lower cost for payors and rewards for consumers. Its application engages consumers through providing targeted incentive plans, delivering reminders and information, and sharing cost savings that help them build healthy habits and foster disease management. It focuses on reducing the cost of the healthcare system by encouraging consumers to manage their diseases and to take preventative actions to stay healthy. Wellth is based in New York, New York.

Actym Therapeutics is an immunotherapy company based in Berkeley, California, founded in 2017. The company specializes in developing innovative therapies for cancer treatment, particularly through its proprietary immuno-oncology platform. Actym focuses on engineering immunotherapies that target the tumor microenvironment to enhance the effectiveness of cancer treatments. Its approach includes the development of a novel, tumor-targeting, systemically-delivered STING pathway agonist, which has shown promising anti-tumor activity. By addressing the limitations of existing therapies, Actym aims to provide patients with durable benefits and improved outcomes in the fight against various forms of cancer.

Rgenta Therapeutics develops a pipeline of oral, small-molecule RNA-targeting medicines with an initial focus on oncology. Its proprietary platform mines the massive genomics data to identify targetable RNA processing events and design small-molecule glue to modulate the interactions among the spliceosome, regulatory proteins, and RNAs. Its lead programs and unique approach are unlocking the therapeutic potential of historically undruggable targets in human diseases. It was founded in 2018 and is headquartered in Cambridge, Massachusetts.

HepaRegeniX GmbH, founded in 2016 and based in Ulm, Germany, focuses on developing innovative drugs for the treatment of acute and chronic liver diseases. The company’s approach centers on the mitogen-activated protein kinase (MAPK) pathway, specifically targeting MAP kinase kinase 4 (MKK4), a crucial regulator of liver regeneration. Research conducted by Professor Lars Zender and his team at the University Hospital Tübingen has demonstrated that small RNA molecules can suppress MKK4 gene expression, thereby restoring the regenerative capacity of hepatocytes even in severely diseased livers. HepaRegeniX is advancing the development of small-molecule MKK4 inhibitors, which have the potential to address liver disorders, including nonalcoholic steatohepatitis, by enhancing liver regeneration.

NBE-Therapeutics GmbH is a privately owned biotechnology company based in Basel, Switzerland, founded in 2012. The company specializes in the development of antibody-drug conjugates (ADCs) aimed at enhancing cancer treatment options. NBE-Therapeutics focuses on creating immune-stimulatory therapies through its proprietary ADC platform, which utilizes a unique anthracycline payload. This innovative approach not only targets tumor cells directly but also aims to induce a durable immunological response against tumors. By developing these advanced therapies, NBE-Therapeutics seeks to improve survival rates and enhance the quality of life for cancer patients globally.

Eyevensys S.A.S. is a Paris-based company that specializes in non-viral gene therapy for ophthalmology. Founded in 2008, it focuses on developing innovative solutions to improve drug delivery methods for ocular diseases. The company utilizes its proprietary Electro-Transfection (ET) technology to administer plasmids to the ciliary muscle, allowing for the sustained release of therapeutic proteins directly into the vitreous, addressing conditions such as uveitis, age-related macular degeneration, and various retinopathies, including central retinal vein occlusion and diabetic retinopathy. Eyevensys aims to overcome the limitations of current treatment options, which often involve invasive procedures like intravitreal injections and surgeries. By enhancing compliance, ocular bioavailability, and tolerability, Eyevensys seeks to create a robust product pipeline that delivers improved clinical outcomes while minimizing the need for frequent and invasive interventions.

Metabomed is a drug discovery company focused on developing treatments for cancer by targeting the unique metabolic pathways of cancer cells. Utilizing a proprietary platform that integrates computational biology, genomics, and metabolomics, Metabomed identifies specific metabolic alterations associated with cancer growth. The company's small molecule drugs are designed to halt the proliferation of reprogrammed cancer cells, which allows oncologists to initiate treatment more swiftly and enhances the chances of successful patient outcomes while minimizing harm to healthy tissues. Through its innovative approach, Metabomed aims to advance cancer treatment by addressing the metabolic characteristics that distinguish cancer cells from normal cells.

ImCheck Therapeutics SAS is a biopharmaceutical company based in Marseille, France, founded in 2015. The company specializes in the development of immunotherapeutics aimed at addressing severe unmet medical needs, primarily in the field of immuno-oncology. ImCheck focuses on creating immuno-modulatory antibodies that target members of the butyrophilin super-family of checkpoint molecules, specifically engaging γ9δ2 T cells. Its research and development efforts are directed toward treating various cancers, including breast, gastric, and ovarian cancers, as well as other immune-related diseases. The company's innovative approach positions it at the forefront of next-generation immunotherapy solutions for patients suffering from solid tumors.

Abalos Therapeutics GmbH is a biotechnology company based in Essen, Germany, focused on developing innovative immuno-oncology therapeutics. Founded in 2019, the company specializes in arenavirus-based drug candidates aimed at stimulating immune responses to target primary tumors and metastases. Utilizing its proprietary Fast Evolution platform, Abalos Therapeutics generates virus strains with optimized anti-tumoral properties. The company's approach involves reprogramming the immune system to effectively identify and eliminate malignant tumor tissue, thereby offering potential new treatment options for cancer. Through its novel immuno-virotherapy, Abalos Therapeutics seeks to harness the full capabilities of the immune system specifically against cancer cells.

T3 Pharmaceuticals AG is a biopharmaceutical company based in Basel, Switzerland, founded in 2015. The company focuses on the research and development of bacteria-based therapies specifically designed for cancer treatment. Recognizing the ongoing need for innovative solutions in oncology, T3 Pharmaceuticals aims to enhance the lives of cancer patients by creating highly specific and efficient treatments using live bacteria. Through its work, the company seeks to address the limitations of conventional therapies and contribute to the advancement of novel cancer medicines.

Tacalyx GmbH is an oncology company based in Berlin, Germany, specializing in the discovery and development of therapeutics targeting Tumor Associated Carbohydrate Antigens (TACAs) found on the surface of metastatic tumors. These carbohydrate antigens are unique to cancer cells, resulting from abnormal glycosylation processes that enhance tumor aggressiveness and immune evasion. Tacalyx leverages a technology platform that enables the synthesis and analysis of complex carbohydrate structures, facilitating the creation of novel immunotherapies. By focusing on these cancer-specific targets, Tacalyx aims to develop effective treatments for malignancies where existing therapies are inadequate, ultimately enhancing the ability of physicians to trigger robust anti-cancer responses.

Amal Therapeutics SA is a biotech company based in Geneva, Switzerland, founded in 2012 as a spin-off from the University of Geneva. The company focuses on the research and development of therapeutic vaccines for oncology, utilizing its proprietary cell penetrating peptide platform. Amal Therapeutics aims to create innovative therapeutic cancer vaccines and immunotherapies to enhance treatment options for cancer patients. As of July 2019, Amal Therapeutics operates as a subsidiary of Boehringer Ingelheim GmbH.

Dopavision GmbH, founded in 2017 and based in Berlin, Germany, focuses on developing a digital therapeutic for myopia, or shortsightedness, a common visual condition affecting around one in three individuals globally. The company aims to create a clinically validated therapy to slow the progression of myopia in children and adolescents. Its innovative technology employs light stimulation targeting specific photosensitive cells in the retina, which modulates dopamine levels—a neurotransmitter that plays a crucial role in eye growth regulation. This digital therapeutic can be seamlessly integrated with smartphone use, making it an accessible solution for health professionals treating myopia. Dopavision is also supported by the German government through the "Industrie-in-Klinik" program, receiving €1.4 million over three years to advance its research and development efforts.

OncoMyx Therapeutics, Inc. is a biotechnology company specializing in the development of oncolytic immunotherapies utilizing the myxoma virus (MYXV) to stimulate immune responses against cancer. Founded in 2018 and based in Phoenix, Arizona, the company focuses on targeting both hematologic and solid tumors through its innovative MYXV platform. This platform employs a novel systemic delivery method that allows the myxoma virus to be carried by human leukocytes, enabling it to effectively infect tumor cells. By assembling a highly skilled team in oncolytic virus research, OncoMyx aims to advance a pipeline of therapeutic options designed to improve outcomes for cancer patients.

Rinri Therapeutics is a provider of private biotechnology services intended to develop advanced regenerative stem cell-based therapies for the treatment of hearing loss. The company's stem cell technology replaces damaged or dead sensory cells of the inner ear, enabling doctors to restore hearing of patients.

AgomAb is developing molecular therapies for the regeneration of damaged tissues. Their unique agonistic monoclonal antibody molecules (“agomAbs”) stimulate molecular and cellular repair mechanisms that have the potential to restore organ function in patients with fibrotic, inflammatory, autoimmune and degenerative diseases.

AgomAb is developing molecular therapies for the regeneration of damaged tissues. Their unique agonistic monoclonal antibody molecules (“agomAbs”) stimulate molecular and cellular repair mechanisms that have the potential to restore organ function in patients with fibrotic, inflammatory, autoimmune and degenerative diseases.

ICD Therapeutics is a privately held MacroDel biologics-delivery platform developer.

T-knife is a biotechnology company focused on developing T cell receptor therapies aimed at treating cancer. Utilizing a humanized T cell receptor (TCR) mice platform, the company is capable of carrying human TCRαβ gene loci and recombining a diverse array of human TCRs. This innovative approach facilitates the efficient generation and virtual selection of T cell receptors tailored for specific human tumor antigens, enhancing the potential for effective cancer therapies. Through its advanced technology, T-knife aims to improve treatment options for patients battling cancer.

Amal Therapeutics SA is a biotech company based in Geneva, Switzerland, founded in 2012 as a spin-off from the University of Geneva. The company focuses on the research and development of therapeutic vaccines for oncology, utilizing its proprietary cell penetrating peptide platform. Amal Therapeutics aims to create innovative therapeutic cancer vaccines and immunotherapies to enhance treatment options for cancer patients. As of July 2019, Amal Therapeutics operates as a subsidiary of Boehringer Ingelheim GmbH.

ViraTherapeutics GmbH, founded in 2013 and located in Innsbruck, Austria, specializes in the development of anti-cancer therapeutics utilizing oncolytic viruses. The company's primary product, VSV-GP, is an innovative oncolytic virus designed to effectively target and destroy cancer cells while sparing normal tissues from damage. ViraTherapeutics is currently engaged in preclinical studies to evaluate the safety and efficacy of VSV-GP, with plans to initiate clinical trials involving cancer patients in the future. In addition to VSV-GP, the company is also focused on developing oncolytic cancer vaccines based on a chimeric virus derived from the vesicular stomatitis virus, advancing the potential of viral therapies in oncology.

Wellth develops and operates a mobile application to lower cost for payors and rewards for consumers. Its application engages consumers through providing targeted incentive plans, delivering reminders and information, and sharing cost savings that help them build healthy habits and foster disease management. It focuses on reducing the cost of the healthcare system by encouraging consumers to manage their diseases and to take preventative actions to stay healthy. Wellth is based in New York, New York.

MabVax Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing and commercializing innovative anti-cancer immunotherapies. The company utilizes two primary technology platforms: a series of cancer vaccines developed at Memorial Sloan-Kettering Cancer Center, which are currently in Phase II clinical trials for soft tissue sarcoma and ovarian cancer, and a human antibody discovery platform that leverages immune responses from patients successfully immunized with these vaccines. MabVax’s lead human antibody candidate is in preclinical evaluation for potential treatments targeting colon, pancreatic, and breast cancers. The company has secured significant federal grant funding to support its research and development efforts, underscoring its commitment to advancing novel therapeutic options for cancer patients.

NBE-Therapeutics GmbH is a privately owned biotechnology company based in Basel, Switzerland, founded in 2012. The company specializes in the development of antibody-drug conjugates (ADCs) aimed at enhancing cancer treatment options. NBE-Therapeutics focuses on creating immune-stimulatory therapies through its proprietary ADC platform, which utilizes a unique anthracycline payload. This innovative approach not only targets tumor cells directly but also aims to induce a durable immunological response against tumors. By developing these advanced therapies, NBE-Therapeutics seeks to improve survival rates and enhance the quality of life for cancer patients globally.

Acousia Therapeutics GmbH is a biotech company based in Tübingen, Germany, founded in 2012. It focuses on developing small molecule drugs aimed at treating hearing loss through local application. The company's innovative approach targets the regeneration of sensory hair cells in the inner ear, which are essential for hearing. By stimulating cellular regeneration from supporting cells, Acousia's therapies aim to restore hearing in patients affected by various conditions, including noise trauma, ototoxic drug treatment, and sudden deafness. Additionally, its research and development efforts are directed towards addressing age-related hearing decline.

Since launching as a spin-out from the University of Oxford in 2010, Brainomix has developed award-winning, AI-powered imaging biomarkers, assisting physicians across the world to make better life-saving decisions. Brainomix seminal product, e-Stroke is a collection of tools that use state-of-the-art AI algorithms to support doctors by providing real-time interpretation of brain scans to help guide treatment and transfer decisions for stroke patients, allowing more patients to get the right treatment, in the right place, at the right time.

Rewind Therapeutics focuses on developing innovative therapeutics aimed at treating neurological diseases. The company specializes in first-in-class remyelinating therapies that target and block inhibitory signals, which hinder the expansion and migration of oligodendrocyte stem cells. By promoting effective remyelination, these therapeutics offer a potential solution for medical practitioners treating patients with multiple sclerosis and other conditions related to myelin damage.

Greybox Solutions is a healthcare management platform focused on enhancing patient quality of life. The platform utilizes real-time surveillance and management tools to monitor patients' treatment and conditions. By integrating wearable applications, it enables healthcare institutions to effectively manage chronic care, thereby alleviating the financial burden associated with such conditions.

Aelin Therapeutics is a Belgian biotherapeutics company established in 2017 and headquartered in Heverlee. It specializes in developing innovative antibiotics and therapeutics through its proprietary Pept-in technology, which utilizes protein aggregation to achieve functional knockdown of target proteins. This platform is designed to address challenging medical conditions, including infections caused by Methicillin-resistant Staphylococcus aureus (MRSA) and other undruggable targets in humans. The company was founded by VIB in collaboration with partner universities, including KU Leuven, VUB, and UGent, and is backed by extensive preclinical proof-of-concept data. Aelin Therapeutics' approach allows for the rational design of novel biotherapeutics, distinguishing itself from traditional therapeutic modalities by targeting intracellular spaces typically inaccessible to small molecules or antibodies. The technology's versatility extends beyond human applications, demonstrating efficacy against bacteria, cancer cells, fungi, viruses, and even plant cells.

Hookipa Pharma is a clinical-stage biopharmaceutical company focused on developing immune-therapeutics for infectious diseases and cancers using its proprietary arenavirus platform. The company's key platforms, Vaxwave and TheraT, aim to elicit robust immune responses, including high levels of neutralizing antibodies and T cells, which are often lacking in traditional therapies. Hookipa's product pipeline features HB-101, a vaccine targeting cytomegalovirus, and HB-201 and HB-202, which are in preclinical studies for human papillomavirus-positive cancers. Additionally, the company is collaborating with Gilead Sciences to create therapies for chronic Hepatitis B and HIV infections. Founded in 2011 and headquartered in New York, Hookipa Pharma aims to transform the field of immunotherapy through its innovative approaches.

Topas Therapeutics GmbH is a biotechnology company based in Hamburg, Germany, focused on developing nanoparticle-based therapeutics to address significant unmet medical needs, particularly in autoimmune diseases, allergies, and anti-drug antibodies. The company utilizes its proprietary Topas Particle Conjugates technology platform to induce antigen-specific immune tolerance by leveraging the liver's natural immunological processes. This approach targets liver sinusoidal endothelial cells to promote tolerance against blood-borne antigens. Topas is advancing several clinical-stage programs, with its lead candidate, TPM203, currently in clinical testing for pemphigus vulgaris, an orphan disease. Other therapeutic programs under development include treatments for celiac disease, Type 1 diabetes, and multiple sclerosis. The company has established research collaborations with Eli Lilly and Company and Boehringer Ingelheim to enhance its capabilities in antigen-specific tolerance induction and anti-drug antibodies, respectively. Topas Therapeutics was incorporated in 2013 and is dedicated to finding innovative solutions for chronic immunological conditions.

Amal Therapeutics SA is a biotech company based in Geneva, Switzerland, founded in 2012 as a spin-off from the University of Geneva. The company focuses on the research and development of therapeutic vaccines for oncology, utilizing its proprietary cell penetrating peptide platform. Amal Therapeutics aims to create innovative therapeutic cancer vaccines and immunotherapies to enhance treatment options for cancer patients. As of July 2019, Amal Therapeutics operates as a subsidiary of Boehringer Ingelheim GmbH.

Cardior Pharmaceuticals GmbH is a biotechnology company based in Hanover, Germany, established in 2016. The company specializes in developing non-coding RNA-based therapeutics aimed at treating and preventing heart disease, which is a leading cause of mortality in the western world. Its primary focus is on CDR-132X, an oligonucleotide-based inhibitor that targets a specific microRNA, which serves as a molecular master switch regulating pathological changes in the heart due to stress or injury. Cardior Pharmaceuticals is committed to discovering and clinically validating innovative therapies that address the underlying causes of cardiac dysfunction, ultimately striving to improve patients' health and quality of life.

ImCheck Therapeutics SAS is a biopharmaceutical company based in Marseille, France, founded in 2015. The company specializes in the development of immunotherapeutics aimed at addressing severe unmet medical needs, primarily in the field of immuno-oncology. ImCheck focuses on creating immuno-modulatory antibodies that target members of the butyrophilin super-family of checkpoint molecules, specifically engaging γ9δ2 T cells. Its research and development efforts are directed toward treating various cancers, including breast, gastric, and ovarian cancers, as well as other immune-related diseases. The company's innovative approach positions it at the forefront of next-generation immunotherapy solutions for patients suffering from solid tumors.

Sentien Biotechnologies, Inc. develops proprietary cell compositions and GMP manufacturing methods to advance combination products that unlock the potential of cell therapy. It provides the Sentinel, a device that actively treats patients during a dialysis dose by supplementing patient blood with MSC-derived secretions, a combinational mixture of natural anti-inflammatory and trophic molecules that can attenuate the immune dysfunction of acute renal failure while promoting a tissue repairing response. The company was founded in 2008 and is headquartered in Medford, Massachusetts.

Sentieon, Inc. is a biotechnology company founded in 2014 and headquartered in Mountain View, California, specializing in cloud-based bioinformatics solutions for the life sciences and clinical markets. The company develops a suite of bioinformatics tools designed for the efficient processing of genomics data, focusing on high accuracy and computational efficiency. Key products include Sentieon DNAseq, which facilitates germline DNA analysis, and Sentieon TNseq, used for detecting somatic variants in tumor-normal samples. Sentieon's software solutions are characterized by their scalability, deployability, and upgradability, allowing them to adapt to various user needs. The company's advanced algorithms and robust software implementation ensure rapid turnaround times and consistent results, benefiting scientists, clinicians, and patients by enhancing precision in genomic data analysis.

HepaRegeniX GmbH, founded in 2016 and based in Ulm, Germany, focuses on developing innovative drugs for the treatment of acute and chronic liver diseases. The company’s approach centers on the mitogen-activated protein kinase (MAPK) pathway, specifically targeting MAP kinase kinase 4 (MKK4), a crucial regulator of liver regeneration. Research conducted by Professor Lars Zender and his team at the University Hospital Tübingen has demonstrated that small RNA molecules can suppress MKK4 gene expression, thereby restoring the regenerative capacity of hepatocytes even in severely diseased livers. HepaRegeniX is advancing the development of small-molecule MKK4 inhibitors, which have the potential to address liver disorders, including nonalcoholic steatohepatitis, by enhancing liver regeneration.

Acousia Therapeutics GmbH is a biotech company based in Tübingen, Germany, founded in 2012. It focuses on developing small molecule drugs aimed at treating hearing loss through local application. The company's innovative approach targets the regeneration of sensory hair cells in the inner ear, which are essential for hearing. By stimulating cellular regeneration from supporting cells, Acousia's therapies aim to restore hearing in patients affected by various conditions, including noise trauma, ototoxic drug treatment, and sudden deafness. Additionally, its research and development efforts are directed towards addressing age-related hearing decline.

Hookipa Pharma is a clinical-stage biopharmaceutical company focused on developing immune-therapeutics for infectious diseases and cancers using its proprietary arenavirus platform. The company's key platforms, Vaxwave and TheraT, aim to elicit robust immune responses, including high levels of neutralizing antibodies and T cells, which are often lacking in traditional therapies. Hookipa's product pipeline features HB-101, a vaccine targeting cytomegalovirus, and HB-201 and HB-202, which are in preclinical studies for human papillomavirus-positive cancers. Additionally, the company is collaborating with Gilead Sciences to create therapies for chronic Hepatitis B and HIV infections. Founded in 2011 and headquartered in New York, Hookipa Pharma aims to transform the field of immunotherapy through its innovative approaches.

NBE-Therapeutics GmbH is a privately owned biotechnology company based in Basel, Switzerland, founded in 2012. The company specializes in the development of antibody-drug conjugates (ADCs) aimed at enhancing cancer treatment options. NBE-Therapeutics focuses on creating immune-stimulatory therapies through its proprietary ADC platform, which utilizes a unique anthracycline payload. This innovative approach not only targets tumor cells directly but also aims to induce a durable immunological response against tumors. By developing these advanced therapies, NBE-Therapeutics seeks to improve survival rates and enhance the quality of life for cancer patients globally.

Promethera Biosciences is a clinical-stage biopharmaceutical company focused on developing innovative therapies for liver diseases. Founded in 2009 and based in Mont-Saint-Guibert, Belgium, with an office in Tokyo, Japan, the company specializes in cell therapy products, notably HepaStem and H2Stem, which utilize allogeneic progenitor cells derived from healthy human adult livers. Promethera is actively working on treatments for a range of conditions, including acute-on-chronic liver failure, hemophilia, liver fibrosis, non-alcoholic steatohepatitis, liver-based metabolic diseases, and urea cycle disorders. The company also engages in strategic alliances to further its research and development efforts, enhancing its capacity to discover and commercialize effective cell therapies for liver-related ailments.

Rigontec GmbH is a biopharmaceutical company specializing in RNA-based immunotherapeutics aimed at treating cancer and viral diseases. Founded in 2014 and based in Planegg, Germany, the company focuses on developing compounds that activate the immune receptor retinoic acid-inducible gene I (RIG-I), specifically through its lead product, ImOl100. This compound acts as a minimal mimic of the naturally occurring 3pRNA motif found in viral RNAs, stimulating the immune response effectively. Rigontec's approach circumvents common challenges faced by traditional cancer therapies, such as vaccines and checkpoint inhibitors, by targeting RIG-I pathways to induce tumor cell death and promote long-term immunity. In 2017, Rigontec became a subsidiary of Merck & Co., Inc., enhancing its capabilities in the field of immuno-oncology.

STAT-Dx Life S.L. is a Barcelona-based company that specializes in the development, manufacturing, and marketing of molecular diagnostic systems. Established in 2010, the company focuses on creating near-patient testing products aimed at providing timely and efficient patient care, particularly in critical care environments. Its flagship product, the DiagCORE, is a portable multi-analyte instrument designed for molecular and immunoassay testing across various clinical settings. STAT-Dx offers several diagnostic panels, including the DiagCORE Cartridge for syndrome testing, the DiagCORE Analyzer for modular analysis, and specific panels for respiratory, gastrointestinal, central nervous system, pneumonia, and blood culture identification. In 2018, STAT-Dx became a subsidiary of QIAGEN N.V., further enhancing its capabilities in the diagnostics field.

Metabomed is a drug discovery company focused on developing treatments for cancer by targeting the unique metabolic pathways of cancer cells. Utilizing a proprietary platform that integrates computational biology, genomics, and metabolomics, Metabomed identifies specific metabolic alterations associated with cancer growth. The company's small molecule drugs are designed to halt the proliferation of reprogrammed cancer cells, which allows oncologists to initiate treatment more swiftly and enhances the chances of successful patient outcomes while minimizing harm to healthy tissues. Through its innovative approach, Metabomed aims to advance cancer treatment by addressing the metabolic characteristics that distinguish cancer cells from normal cells.

Amal Therapeutics SA is a biotech company based in Geneva, Switzerland, founded in 2012 as a spin-off from the University of Geneva. The company focuses on the research and development of therapeutic vaccines for oncology, utilizing its proprietary cell penetrating peptide platform. Amal Therapeutics aims to create innovative therapeutic cancer vaccines and immunotherapies to enhance treatment options for cancer patients. As of July 2019, Amal Therapeutics operates as a subsidiary of Boehringer Ingelheim GmbH.

eTheRNA immunotherapies NV specializes in the development of mRNA-based immunotherapies aimed at enhancing the human immune system's response to cancer and infectious diseases. The company's innovative TriMix technology specifically targets dendritic cells, which play a crucial role in initiating immune responses. By harnessing this technology, eTheRNA seeks to provide more effective and safer treatment options for patients with conditions such as melanoma and triple-negative breast cancer. Founded in 2013 and headquartered in Niel, Belgium, eTheRNA has established a strategic partnership with China Grand Pharmaceutical and Healthcare Holdings Limited to further its research and development efforts. The company is dedicated to advancing the field of immunotherapy to improve patient outcomes.

ViraTherapeutics GmbH, founded in 2013 and located in Innsbruck, Austria, specializes in the development of anti-cancer therapeutics utilizing oncolytic viruses. The company's primary product, VSV-GP, is an innovative oncolytic virus designed to effectively target and destroy cancer cells while sparing normal tissues from damage. ViraTherapeutics is currently engaged in preclinical studies to evaluate the safety and efficacy of VSV-GP, with plans to initiate clinical trials involving cancer patients in the future. In addition to VSV-GP, the company is also focused on developing oncolytic cancer vaccines based on a chimeric virus derived from the vesicular stomatitis virus, advancing the potential of viral therapies in oncology.

Rigontec GmbH is a biopharmaceutical company specializing in RNA-based immunotherapeutics aimed at treating cancer and viral diseases. Founded in 2014 and based in Planegg, Germany, the company focuses on developing compounds that activate the immune receptor retinoic acid-inducible gene I (RIG-I), specifically through its lead product, ImOl100. This compound acts as a minimal mimic of the naturally occurring 3pRNA motif found in viral RNAs, stimulating the immune response effectively. Rigontec's approach circumvents common challenges faced by traditional cancer therapies, such as vaccines and checkpoint inhibitors, by targeting RIG-I pathways to induce tumor cell death and promote long-term immunity. In 2017, Rigontec became a subsidiary of Merck & Co., Inc., enhancing its capabilities in the field of immuno-oncology.

NBE-Therapeutics GmbH is a privately owned biotechnology company based in Basel, Switzerland, founded in 2012. The company specializes in the development of antibody-drug conjugates (ADCs) aimed at enhancing cancer treatment options. NBE-Therapeutics focuses on creating immune-stimulatory therapies through its proprietary ADC platform, which utilizes a unique anthracycline payload. This innovative approach not only targets tumor cells directly but also aims to induce a durable immunological response against tumors. By developing these advanced therapies, NBE-Therapeutics seeks to improve survival rates and enhance the quality of life for cancer patients globally.

Promethera Biosciences is a clinical-stage biopharmaceutical company focused on developing innovative therapies for liver diseases. Founded in 2009 and based in Mont-Saint-Guibert, Belgium, with an office in Tokyo, Japan, the company specializes in cell therapy products, notably HepaStem and H2Stem, which utilize allogeneic progenitor cells derived from healthy human adult livers. Promethera is actively working on treatments for a range of conditions, including acute-on-chronic liver failure, hemophilia, liver fibrosis, non-alcoholic steatohepatitis, liver-based metabolic diseases, and urea cycle disorders. The company also engages in strategic alliances to further its research and development efforts, enhancing its capacity to discover and commercialize effective cell therapies for liver-related ailments.

Rigontec GmbH is a biopharmaceutical company specializing in RNA-based immunotherapeutics aimed at treating cancer and viral diseases. Founded in 2014 and based in Planegg, Germany, the company focuses on developing compounds that activate the immune receptor retinoic acid-inducible gene I (RIG-I), specifically through its lead product, ImOl100. This compound acts as a minimal mimic of the naturally occurring 3pRNA motif found in viral RNAs, stimulating the immune response effectively. Rigontec's approach circumvents common challenges faced by traditional cancer therapies, such as vaccines and checkpoint inhibitors, by targeting RIG-I pathways to induce tumor cell death and promote long-term immunity. In 2017, Rigontec became a subsidiary of Merck & Co., Inc., enhancing its capabilities in the field of immuno-oncology.

Hookipa Pharma is a clinical-stage biopharmaceutical company focused on developing immune-therapeutics for infectious diseases and cancers using its proprietary arenavirus platform. The company's key platforms, Vaxwave and TheraT, aim to elicit robust immune responses, including high levels of neutralizing antibodies and T cells, which are often lacking in traditional therapies. Hookipa's product pipeline features HB-101, a vaccine targeting cytomegalovirus, and HB-201 and HB-202, which are in preclinical studies for human papillomavirus-positive cancers. Additionally, the company is collaborating with Gilead Sciences to create therapies for chronic Hepatitis B and HIV infections. Founded in 2011 and headquartered in New York, Hookipa Pharma aims to transform the field of immunotherapy through its innovative approaches.

STAT-Dx Life S.L. is a Barcelona-based company that specializes in the development, manufacturing, and marketing of molecular diagnostic systems. Established in 2010, the company focuses on creating near-patient testing products aimed at providing timely and efficient patient care, particularly in critical care environments. Its flagship product, the DiagCORE, is a portable multi-analyte instrument designed for molecular and immunoassay testing across various clinical settings. STAT-Dx offers several diagnostic panels, including the DiagCORE Cartridge for syndrome testing, the DiagCORE Analyzer for modular analysis, and specific panels for respiratory, gastrointestinal, central nervous system, pneumonia, and blood culture identification. In 2018, STAT-Dx became a subsidiary of QIAGEN N.V., further enhancing its capabilities in the diagnostics field.

Eyevensys S.A.S. is a Paris-based company that specializes in non-viral gene therapy for ophthalmology. Founded in 2008, it focuses on developing innovative solutions to improve drug delivery methods for ocular diseases. The company utilizes its proprietary Electro-Transfection (ET) technology to administer plasmids to the ciliary muscle, allowing for the sustained release of therapeutic proteins directly into the vitreous, addressing conditions such as uveitis, age-related macular degeneration, and various retinopathies, including central retinal vein occlusion and diabetic retinopathy. Eyevensys aims to overcome the limitations of current treatment options, which often involve invasive procedures like intravitreal injections and surgeries. By enhancing compliance, ocular bioavailability, and tolerability, Eyevensys seeks to create a robust product pipeline that delivers improved clinical outcomes while minimizing the need for frequent and invasive interventions.

NBE-Therapeutics GmbH is a privately owned biotechnology company based in Basel, Switzerland, founded in 2012. The company specializes in the development of antibody-drug conjugates (ADCs) aimed at enhancing cancer treatment options. NBE-Therapeutics focuses on creating immune-stimulatory therapies through its proprietary ADC platform, which utilizes a unique anthracycline payload. This innovative approach not only targets tumor cells directly but also aims to induce a durable immunological response against tumors. By developing these advanced therapies, NBE-Therapeutics seeks to improve survival rates and enhance the quality of life for cancer patients globally.

ArmaGen, Inc. is a clinical stage biotechnology company that develops therapies to treat severe neurological diseases. The company focuses on therapies for lysosomal storage, hunter syndrome, hurler syndrome, Sanfilippo A syndrome, metachromatic leukodystrophy, and neurodegenerative diseases. Its product candidates include AGT-182 for hunter syndrome; and AGT-181 for hurler syndrome. The company was formerly known as ArmaGen Technologies, Inc. ArmaGen, Inc. was incorporated in 2001 and is headquartered in San Diego, California.

Funxional Therapeutics Ltd. develops pharmaceutical products in the United Kingdom. Its product candidates include BN83470 for the treatment of respiratory indications, initially asthma; BN83250 for the prevention of surgical adhesion formation and for the treatment of stroke; and FX125L, an orally available small molecule that belongs to a therapeutic class named broad spectrum chemokine inhibitors. The company also offers early stage preclinical programs that focus on Alzheimer's disease, autoimmune disorders, and pain and diabetes. Funxional Therapeutics Ltd. as founded in 2005 and is based in Cambridge, the United Kingdom.

Promethera Biosciences is a clinical-stage biopharmaceutical company focused on developing innovative therapies for liver diseases. Founded in 2009 and based in Mont-Saint-Guibert, Belgium, with an office in Tokyo, Japan, the company specializes in cell therapy products, notably HepaStem and H2Stem, which utilize allogeneic progenitor cells derived from healthy human adult livers. Promethera is actively working on treatments for a range of conditions, including acute-on-chronic liver failure, hemophilia, liver fibrosis, non-alcoholic steatohepatitis, liver-based metabolic diseases, and urea cycle disorders. The company also engages in strategic alliances to further its research and development efforts, enhancing its capacity to discover and commercialize effective cell therapies for liver-related ailments.

Okairos AG is a biopharmaceutical company that specializes in the discovery and development of genetic T-cell vaccines, with a significant focus on combating the hepatitis C virus. The company is also involved in providing health and allied services. Headquartered in Basel, Switzerland, Okairos operates in Rome and Naples, Italy. It has expertise in gene delivery technologies and scalable viral-vector manufacturing processes, which facilitate the advancement of vaccines and advanced therapies. By utilizing state-of-the-art GMP facilities, Okairos supports biotech companies in transitioning their genetic vaccines and medicinal products from preclinical stages to commercial readiness.

Actimis Pharmaceuticals, Inc., is a start-up biopharmaceutical company focused on the development of small molecule therapeutics for respiratory and inflammatory disorders. Actimis was created as a spin-off from the respiratory diseases therapeutic research portfolio of Bayer Healthcare AG. The spin-off was founded by Dr. Kevin Bacon and has received venture financing from a syndicate lead by Sanderling Ventures of San Mateo, California and Mitsui & Co Venture Partners of New York. Dr. Bacon was most recently Vice President and Global Head of Respiratory diseases research at Bayer Yakuhin Ltd., Japan where the programs were initiated.

International Diagnostic Technology is a manufacturer of diagnostic kits for food safety, and for drugs of abuse in dogs and horses. It was established in St. Joseph, Michigan.