Boston Harbor Angels

Astrocyte Pharmaceuticals Inc. is a drug development company focused on creating neuroprotection therapies for conditions such as traumatic brain injuries (TBI), concussions, acute ischemic stroke, and neurodegenerative disorders like Alzheimer's disease. Founded in 2014 and located in Cambridge, Massachusetts, the company is dedicated to demonstrating the neuroprotective benefits of selectively activating astrocytes. Its lead product, AST-004, is a novel small molecule designed for acute administration, aiming to protect and repair damaged neurons. Through its innovative approaches, Astrocyte Pharmaceuticals seeks to improve the recovery and well-being of patients suffering from brain injuries.

Zylo Therapeutics, Inc. is a life sciences company based in Greenville, South Carolina, specializing in a sustained-release drug delivery system. Founded in 2017, the company has developed a delivery mechanism that employs patented hydrogel-derived nanoparticles, known as Nanopods™, to facilitate the topical administration of difficult-to-deliver therapeutic agents, including nitric oxide. This innovative system enhances drug delivery capabilities and is designed to improve the treatment of various conditions such as lupus, hair loss, joint pain, and burns. By utilizing engineered amorphous silica particles, Zylo Therapeutics aims to provide a controlled and sustained release of medications, thereby enhancing product performance and patient outcomes.

Xeno Biosciences Inc. is a biopharmaceutical company based in Somerville, Massachusetts, established in 2015. It specializes in developing innovative therapeutics aimed at addressing significant unmet needs in metabolic diseases, particularly obesity. The company's lead program, XEN-101, is an oral formulation that mimics the microbiome shift associated with Roux-en-Y Gastric Bypass (RYGB) surgery, promoting weight loss. Xeno Biosciences' approach involves a simple enteric-coated pill that delivers molecular oxygen to the lower gut, enabling a treatment strategy that replicates the effects of gastric bypass surgery on the gut microbiome.

Enrich Therapeutics Inc. is a biotechnology company that specializes in developing innovative single-cell isolation technologies for life science research. The company offers LASUM, a technology that enables the selection and isolation of single cells under a microscope, applicable to various cell types, including suspension cells, adherent cells, and challenging tissue samples. This technology enhances scalability and affordability for critical applications such as antibody drug discovery, next-generation sequencing (NGS), and the development of adoptive cell therapies. Enrich Therapeutics also engages in phage display library engineering, affinity-on-demand binder selection, cell line development for CAR-T immunotherapy, B-cell isolation, and precision cell isolation for NGS analysis. Founded in 2018 and based in Worcester, Massachusetts, the company aims to advance the capabilities of life science research through its tailored solutions.

Powerplay is a developer of project management software specifically designed for the construction and architectural sectors. Its mobile-based operating system, PowerplayOS, serves as a comprehensive app ecosystem that enhances communication between site and office teams. The software features an insightful dashboard that allows users to track activities, manage inventory, and identify potential blockages. Additionally, it facilitates crucial communication for material requests, inwarding notes, goods receiving notes, scheduled plans, and various project highlights and issues. By providing real-time tracking of on-site progress, Powerplay enables businesses to complete projects efficiently and within budget.

Zylo Therapeutics, Inc. is a life sciences company based in Greenville, South Carolina, specializing in a sustained-release drug delivery system. Founded in 2017, the company has developed a delivery mechanism that employs patented hydrogel-derived nanoparticles, known as Nanopods™, to facilitate the topical administration of difficult-to-deliver therapeutic agents, including nitric oxide. This innovative system enhances drug delivery capabilities and is designed to improve the treatment of various conditions such as lupus, hair loss, joint pain, and burns. By utilizing engineered amorphous silica particles, Zylo Therapeutics aims to provide a controlled and sustained release of medications, thereby enhancing product performance and patient outcomes.

DetraPel, Inc. is a cleantech advanced materials company founded in 2013 and based in Framingham, Massachusetts. The company specializes in producing hydrophobic liquid repellent sprays that protect various objects from spills and stains. Utilizing nanotechnology, DetraPel's innovative coatings are PFAS-free and designed to repel dirt effectively while being non-flammable, non-toxic, and non-corrosive. These properties ensure that the product is safe for use on fabrics and shoes, without compromising their texture or material integrity. DetraPel's offerings are also resistant to ultraviolet light, rust, and ice, making them versatile cleaning solutions for consumers seeking to maintain the appearance and longevity of their belongings.

CytoAgents, Inc. is a biotechnology company based in Pittsburgh, Pennsylvania, established in 2018. The company specializes in developing protein-based drugs aimed at treating viral infections, particularly influenza, and addressing life-threatening symptoms associated with Cytokine Release Syndrome (CRS). CRS is an overreaction of the immune system that results in systemic inflammation, often referred to as a cytokine storm. One of its primary products, GP1681, acts as an agonist of a G-protein coupled receptor, targeting the immune response in various medical conditions. CytoAgents focuses on creating treatments for multiple indications with significant unmet medical needs, including those arising from oncology CAR-T cell therapy, COVID-19, and respiratory epidemics, thereby providing healthcare professionals with innovative tools to manage patients experiencing severe immune reactions.

Tunnel is a developer of cloud-based payment software that facilitates real-time global cross-currency payments without transaction fees. Utilizing distributed ledger technology, Tunnel offers its own payment infrastructure, including application programming interfaces and mobile applications. This innovative approach allows both individuals and companies to conduct transactions securely and efficiently, minimizing costs associated with traditional payment methods while enhancing fraud prevention.

Tunnel is a developer of cloud-based payment software that facilitates real-time global cross-currency payments without transaction fees. Utilizing distributed ledger technology, Tunnel offers its own payment infrastructure, including application programming interfaces and mobile applications. This innovative approach allows both individuals and companies to conduct transactions securely and efficiently, minimizing costs associated with traditional payment methods while enhancing fraud prevention.

RevBio is focused on developing innovative bone repair technology through its flagship product, Tetranite, which is an injectable, self-setting, osteoconductive bone adhesive biomaterial. This synthetic adhesive is designed to bond bone to bone and bone to metal in wet environments and is currently under FDA review for various applications in oral, craniofacial, orthopedic, and neurosurgical fields. Tetranite biodegrades over time, being replaced by new bone as part of the natural bone remodeling process, and serves as a scaffold to facilitate bone growth. By reducing the duration and complexity of medical procedures, RevBio's technology enables more minimally invasive surgeries and aims to improve patient outcomes by decreasing recovery time, pain, and overall costs associated with care. The company is building a diverse portfolio of applications within both dental and orthopedic markets.

Astrocyte Pharmaceuticals Inc. is a drug development company focused on creating neuroprotection therapies for conditions such as traumatic brain injuries (TBI), concussions, acute ischemic stroke, and neurodegenerative disorders like Alzheimer's disease. Founded in 2014 and located in Cambridge, Massachusetts, the company is dedicated to demonstrating the neuroprotective benefits of selectively activating astrocytes. Its lead product, AST-004, is a novel small molecule designed for acute administration, aiming to protect and repair damaged neurons. Through its innovative approaches, Astrocyte Pharmaceuticals seeks to improve the recovery and well-being of patients suffering from brain injuries.

Anubis Bio Corporation is a medical nutrition company based in Orlando, Florida, that focuses on developing and manufacturing products aimed at controlling diarrhea in dogs and cats. Incorporated in 2018, the company offers DoggyStat, a product designed to provide symptomatic relief and eliminate infections that cause diarrhea in pets. Anubis Bio utilizes a patented Microbiome-Cleanser natural food platform that addresses gastrointestinal distress in animals, beginning with dogs. The company's approach emphasizes enhancing pet health through natural food products that support digestive health and normal intestinal function. In 2021, Anubis Bio established two significant B2B distribution partnerships to expand its reach in the animal health management sector.

KnipBio, Inc. is a biotechnology company based in Lowell, Massachusetts, established in 2013. It focuses on developing sustainable and responsible feed solutions for the aquaculture industry, primarily through its innovative product, KnipBio Meal (KBM). This product serves as a protein-rich replacement for traditional fishmeal, combining the benefits of high-quality protein and carotenoids in a single, effective formulation. KnipBio employs naturally occurring microbe strains that convert abundant and low-cost feedstocks, such as ethanol and methanol, into nutritious single-cell protein. By addressing the challenges of animal nutrition, KnipBio aims to provide livestock owners with affordable and efficient feed alternatives, contributing to the evolution of sustainable aquaculture practices.

Candidly is an AI-driven student debt and savings optimization platform. It offers individuals and families through every step of the planning, borrowing, and repayment experience.

BrandVerge, Inc. operates an online marketplace and workflow platform designed to streamline collaboration between advertisers and publishers on branded content initiatives. Founded in 2017 and based in New York, the company offers a solution that enhances the efficiency of marketing programs, allowing advertisers to plan and execute media partnerships more effectively. By providing on-demand access to a range of opportunities, BrandVerge facilitates the discovery and activation of relevant content partnerships, significantly improving visibility and generating new business for publishers. The platform simplifies the traditionally manual processes, enabling users to manage their marketing efforts quickly and effectively, ultimately enhancing revenue for media companies while delivering quality leads to advertisers.

DeepLook is a point-and-click tool that integrates mammography workstations to fit with the radiologist’s workflow.

Astrocyte Pharmaceuticals Inc. is a drug development company focused on creating neuroprotection therapies for conditions such as traumatic brain injuries (TBI), concussions, acute ischemic stroke, and neurodegenerative disorders like Alzheimer's disease. Founded in 2014 and located in Cambridge, Massachusetts, the company is dedicated to demonstrating the neuroprotective benefits of selectively activating astrocytes. Its lead product, AST-004, is a novel small molecule designed for acute administration, aiming to protect and repair damaged neurons. Through its innovative approaches, Astrocyte Pharmaceuticals seeks to improve the recovery and well-being of patients suffering from brain injuries.

Quthero specializes in developing innovative solutions for post-surgical scarring prevention through its patented gel technology. This gel is designed to restore moisture and mechanical properties of wounds, facilitating the healing process. By promoting full epithelial restoration, Quthero's product aims to expedite wound closure while minimizing scarring, redness, and bruising. The company's approach supports safe treatment of skin wounds, reducing complications and risks linked to slow healing. Through these advancements, Quthero addresses the needs of individuals recovering from procedures and surgeries, contributing to improved skin health and recovery outcomes.

Astrocyte Pharmaceuticals Inc. is a drug development company focused on creating neuroprotection therapies for conditions such as traumatic brain injuries (TBI), concussions, acute ischemic stroke, and neurodegenerative disorders like Alzheimer's disease. Founded in 2014 and located in Cambridge, Massachusetts, the company is dedicated to demonstrating the neuroprotective benefits of selectively activating astrocytes. Its lead product, AST-004, is a novel small molecule designed for acute administration, aiming to protect and repair damaged neurons. Through its innovative approaches, Astrocyte Pharmaceuticals seeks to improve the recovery and well-being of patients suffering from brain injuries.

PlaceMe simplifies the rental market for young professionals and grad students by leasing all-inclusive fully-furnished bedrooms at a flat monthly rent with flexible lease terms.

Xylyx Bio is a pioneering company in the field of biomaterials, dedicated to improving human health through science-based solutions. The company specializes in developing regenerative biotechnologies, offering tissue-specific extracellular matrix (ECM) substrates and clinically relevant data packages. These products are designed to support scientists in pharmaceutical development, cell biology research, and regenerative medicine. By providing comprehensive components that mimic the natural cell microenvironment, Xylyx Bio enables researchers to achieve precise and actionable results. The company's focus includes enhancing drug discovery processes, particularly for conditions such as fibrosis and scarring, and it aims to facilitate cellular repair and skin health through its innovative solutions.

GoodTwo is an online fundraising platform that enables fundraisers, ranging from individuals to organizations, to generate donations through group buying deals with local and national brands. Users can establish a free fundraising page and select up to three pre-negotiated deals, similar to those found on popular group buying sites. The platform provides tools for fundraisers to promote their campaigns to potential donors, leveraging their own networks. For each deal sold, GoodTwo donates half of its profits to the fundraiser, with the donation amount transparently outlined during the purchasing process. GoodTwo manages all aspects of fulfillment, customer service, and deal negotiation, allowing fundraisers to focus on reaching out to their supporters.

Gramify is personalized audio greetings that feature the voice of celebrities and fictional characters. These are emotionally-engaging alternatives to print cards and ecards. They are bought online and delivered either through a phone call or through Facebook. They started signing licenses and are negotiating with major brands. The best part is the team which include licensing heavyweights who have done hundreds of deals.

Neuraly, Inc. is a clinical-stage biotechnology company based in Germantown, Maryland, focused on discovering and developing innovative treatments for neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. Founded in 2016, Neuraly emerged from research conducted by leading neuroscientists, notably Ted Dawson at Johns Hopkins School of Medicine. The company is known for its neuroprotective agent NLY01, which targets the pathological activation of microglia, and also develops two blood-brain barrier-penetrating kinase inhibitors, NLY02 and NLY03. Neuraly's approach emphasizes the crucial role of glial cells in neurodegenerative disease progression, aiming to prevent neuronal cell death and enhance the quality of life for affected individuals.

NextShift Robotics Inc., founded in 2016 and based in North Billerica, Massachusetts, specializes in designing and developing autonomous mobile robots for material handling in warehouse and manufacturing environments. The company offers innovative solutions for e-commerce order fulfillment, enabling businesses to enhance their operational efficiency and extend warehouse capacity. NextShift’s autonomous robots facilitate a more effective workflow by integrating real-time work tracking and dynamically adjusting to order volume and shipping priorities, all while collaborating seamlessly with warehouse staff. With a focus on rapid deployment and low maintenance, NextShift Robotics aims to address the challenges of accelerated order fulfillment in demanding conditions, leveraging the expertise of its team in material handling and automation.

At lumo,They’re obsessed with making air travel smarter. They predict flight delays months, weeks, hours ahead of time, making planning easier and flight changes less stressful.

Fynalist operates an online platform designed for corporate recruiters and talent acquisition professionals, facilitating the process of finding qualified and active candidates. Founded in 2016 and based in Newton, Massachusetts, the platform functions as a candidate recommendation engine, allowing recruiters to access a pool of vetted candidates who have been recommended by their peers. In addition to talent search and acquisition, Fynalist offers services that include candidate screening, leadership consulting, and executive coaching. This comprehensive approach enables businesses to effectively identify and hire executives with the appropriate skills for both full-time and contractual positions.

Landsdowne is a developer focused on innovative battery technology, specifically designed to address the health risks associated with button batteries. The company is commercializing a solution that deactivates batteries after accidental ingestion, aiming to provide a safe alternative for international businesses. Landsdowne's products not only target the growing health crisis related to button batteries but also include materials for injury prevention, ensuring that vulnerable individuals, such as those with fragile skin, are protected. By offering a turnkey, cost-effective solution, Landsdowne seeks to enhance safety and mitigate the risks posed by button batteries in various applications.

Pyramid Biosciences, Inc. is a biotechnology company based in Waltham, Massachusetts, focused on the discovery and development of targeted therapeutics for disorders regulated by the tropomyosin receptor kinase (TRK) family. The company specializes in creating TRK modulators aimed at treating dermatology and oncology conditions linked to dysregulated TRK signaling pathways. Its notable products include PBI-100, designed for dermatological applications with anti-itch, anti-inflammatory, and antiproliferative properties, and PBI-200, an orally active TRK inhibitor that addresses clinical resistance mutations seen in current TRK therapies for cancer. Incorporated in 2015, Pyramid Biosciences aims to provide precise and selective modulation of TRK signaling to improve patient outcomes.

Green Piñata LLC is an online subscription service based in Wakefield, Massachusetts, specializing in the rental of non-toxic, educational toys for children under five years old. Founded in 2015, the company provides a platform that allows parents to select toys from a curated catalog made from sustainably sourced materials. Customers can choose the toys they wish to rent, and their children can play with them for as long as desired before returning them. Additionally, Green Piñata offers a custom curriculum guide and a toy selection tool that helps match toys to a child's preferences and developmental needs, ensuring that families have access to high-quality, eco-friendly toys that support learning and play.

Xeno Biosciences Inc. is a biopharmaceutical company based in Somerville, Massachusetts, established in 2015. It specializes in developing innovative therapeutics aimed at addressing significant unmet needs in metabolic diseases, particularly obesity. The company's lead program, XEN-101, is an oral formulation that mimics the microbiome shift associated with Roux-en-Y Gastric Bypass (RYGB) surgery, promoting weight loss. Xeno Biosciences' approach involves a simple enteric-coated pill that delivers molecular oxygen to the lower gut, enabling a treatment strategy that replicates the effects of gastric bypass surgery on the gut microbiome.

Archer Roose is a clean wine brand focused on providing affordable and sustainable wine options to modern consumers. The company produces canned wine and other beverages, emphasizing transparency and sustainability in its packaging. By utilizing cans and kegs, Archer Roose aims to make wine more accessible while appealing to a new generation of wine drinkers. Their global portfolio reflects a commitment to quality and innovation, catering to diverse lifestyles and dining experiences.

Platelet BioGenesis, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in the production of donor-independent human platelets derived from pluripotent stem cells for clinical use. Founded in 2014, the company has developed a microfluidic bioreactor designed to generate functional platelets from human stem cell cultures at a commercial scale. These bioreactor-produced platelets are distributed to hospitals and blood banks, providing a vital resource for patients worldwide. The company is also focused on advancing therapeutics within the fields of biotechnology and drug discovery.

RevBio is focused on developing innovative bone repair technology through its flagship product, Tetranite, which is an injectable, self-setting, osteoconductive bone adhesive biomaterial. This synthetic adhesive is designed to bond bone to bone and bone to metal in wet environments and is currently under FDA review for various applications in oral, craniofacial, orthopedic, and neurosurgical fields. Tetranite biodegrades over time, being replaced by new bone as part of the natural bone remodeling process, and serves as a scaffold to facilitate bone growth. By reducing the duration and complexity of medical procedures, RevBio's technology enables more minimally invasive surgeries and aims to improve patient outcomes by decreasing recovery time, pain, and overall costs associated with care. The company is building a diverse portfolio of applications within both dental and orthopedic markets.

Medumo, Inc. is a healthcare technology company based in Boston, Massachusetts, founded in 2013. It offers a care management platform that automates the delivery of timely instructions to patients through SMS and email. Medumo's product, CareTours, provides healthcare organizations with the ability to send automated, turn-by-turn guidance to patients, enhancing engagement while reducing the burden on healthcare staff. By integrating mobile communication and artificial intelligence, Medumo enables providers to deliver the right information at the right time, ultimately improving patient outcomes and fostering a more knowledgeable healthcare environment. In 2019, Medumo became a subsidiary of Koninklijke Philips N.V., further expanding its reach in the healthcare sector.

Sialix Cancer Research provides cancer susceptibility antibodies and cancer-associated nucleoprotein antibodies for breast cancer. They also offer laser-based photodynamic endoscopic diagnosis using 5-aminolevulinic acid for early gastric adenocarcinoma and gastric adenoma.

Siamab Therapeutics is a biopharmaceutical company that focuses on developing therapies aimed at cancers characterized by the presence of abnormal carbohydrates, or glycans, on cancer cells. The company has created a technology platform that facilitates the discovery and development of anti-TACA therapeutic antibodies, which target tumor-associated carbohydrate antigens found in various solid tumors, including ovarian, prostate, pancreatic, gastric, and colon cancers. Founded in 2006 and based in Newton, Massachusetts, Siamab Therapeutics has licensed core technologies from the laboratory of glycobiology expert Ajit Varki. The company collaborates with a team of scientists and advisors specializing in oncology, glycoimmunology, and antibody engineering to advance its therapeutic programs.

Simple Science provides anti-microbial products designed to lead a healthy life. They help people lead healthier lives through healthier products, like their antimicrobial skin therapies that contain no steroids or their household cleaners that contain no harmful chemicals.

Ionica Sciences, Inc. is focused on developing a spectroscopy-based diagnostic platform that utilizes surface enhanced Raman scattering (SERS) technology. Founded in 2013 and headquartered in Ithaca, New York, the company aims to address urgent needs in clinical diagnostics by enabling rapid and accurate identification of vector-borne, sexually transmitted, and neurological diseases. Ionica Sciences is particularly dedicated to creating in-vitro diagnostic assays for Lyme disease and other infectious conditions, allowing medical professionals to detect biologically relevant targets such as pathogens and hormones. By improving diagnostic accuracy, the company seeks to reduce patient suffering, minimize unnecessary antibiotic use, and lower healthcare costs associated with misdiagnoses.

CleanFiber, LLC specializes in producing high-performance cellulose insulation materials made from recycled corrugated cardboard for residential and commercial construction. Founded in 2013 and based in Blasdell, New York, with an additional office in Buffalo, CleanFiber transitioned from its previous name, UltraCell Insulation, in September 2018. The company focuses on providing sustainable, carbon-negative insulation solutions that can be applied in attics, walls, and floors, catering to both new construction and retrofit projects. CleanFiber's products not only enhance fire resistance in buildings but also offer a cost-competitive alternative for construction companies, supporting environmentally friendly building practices. The company is currently expanding its production capabilities to meet growing demand.

KnipBio, Inc. is a biotechnology company based in Lowell, Massachusetts, established in 2013. It focuses on developing sustainable and responsible feed solutions for the aquaculture industry, primarily through its innovative product, KnipBio Meal (KBM). This product serves as a protein-rich replacement for traditional fishmeal, combining the benefits of high-quality protein and carotenoids in a single, effective formulation. KnipBio employs naturally occurring microbe strains that convert abundant and low-cost feedstocks, such as ethanol and methanol, into nutritious single-cell protein. By addressing the challenges of animal nutrition, KnipBio aims to provide livestock owners with affordable and efficient feed alternatives, contributing to the evolution of sustainable aquaculture practices.

Siamab Therapeutics is a biopharmaceutical company that focuses on developing therapies aimed at cancers characterized by the presence of abnormal carbohydrates, or glycans, on cancer cells. The company has created a technology platform that facilitates the discovery and development of anti-TACA therapeutic antibodies, which target tumor-associated carbohydrate antigens found in various solid tumors, including ovarian, prostate, pancreatic, gastric, and colon cancers. Founded in 2006 and based in Newton, Massachusetts, Siamab Therapeutics has licensed core technologies from the laboratory of glycobiology expert Ajit Varki. The company collaborates with a team of scientists and advisors specializing in oncology, glycoimmunology, and antibody engineering to advance its therapeutic programs.

Avaxia Biologics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing oral antibody therapeutics. Founded in 2005, the company aims to address gastrointestinal diseases and other serious conditions through its proprietary antibody platform. Its product pipeline includes treatments for inflammatory bowel diseases, celiac disease, necrotizing enterocolitis, radiation syndrome, oral mucositis, and metabolic disorders such as diabetes and obesity. Avaxia Biologics is also engaged in a strategic collaboration with Courtagen Life Sciences, Inc., enhancing its research and development efforts in creating gut-targeted therapeutics. As a clinical-stage organization, Avaxia Biologics is committed to improving patient outcomes by delivering innovative solutions for complex health challenges.

Blurr is a mobile application designed for iOS that allows users to edit and share photos in an engaging way. The app combines popular social media features such as sharing, gamification, and filters. Users can apply filters to "blurr" their images and set a specific number of likes required to unlock or "de-blurr" the content. This unique approach encourages interaction, as participants can curate and collect content while creating profiles to enhance user engagement. Additionally, Blurr features a leaderboard that showcases trending content and highlights the most popular photos in real-time, further incentivizing users to connect and participate in the platform.

Premama is a company that specializes in prenatal nutrition, offering a doctor-recommended daily multivitamin in a convenient powder form. This product is designed to be easily mixed into cold beverages, yogurt, or smoothies, making it accessible for expectant women. Premama's formulations include essential nutrients such as DHA, folic acid, and B6, which are specifically aimed at improving the nutritional status of pregnant women and alleviating symptoms of morning sickness. The supplements are vegan, gluten-free, and non-GMO, addressing common concerns such as iron-induced constipation. Premama's Complete formula is available at Target, while its Essentials and Plus varieties can be found on Amazon, Buy Buy Baby, and in specialty vitamin and health food stores.

Siva Therapeutics Inc. is a biotechnology company focused on developing innovative nanotechnology solutions for cancer treatment. Founded in 2011 and based in Boulder, Colorado, the company specializes in creating SivaRods, a photothermal device that utilizes heat to irreversibly damage solid tumor tissues. By employing gold nanorods and an infrared light device, Siva Therapeutics offers a therapy that is more selective than traditional chemotherapy, less harmful than radiation, and avoids the risks associated with surgical interventions. The company's mission is to provide safe, minimally invasive, and cost-effective medical device treatments that enhance patient outcomes in the fight against cancer.

Avaxia Biologics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing oral antibody therapeutics. Founded in 2005, the company aims to address gastrointestinal diseases and other serious conditions through its proprietary antibody platform. Its product pipeline includes treatments for inflammatory bowel diseases, celiac disease, necrotizing enterocolitis, radiation syndrome, oral mucositis, and metabolic disorders such as diabetes and obesity. Avaxia Biologics is also engaged in a strategic collaboration with Courtagen Life Sciences, Inc., enhancing its research and development efforts in creating gut-targeted therapeutics. As a clinical-stage organization, Avaxia Biologics is committed to improving patient outcomes by delivering innovative solutions for complex health challenges.

Siva Therapeutics Inc. is a biotechnology company focused on developing innovative nanotechnology solutions for cancer treatment. Founded in 2011 and based in Boulder, Colorado, the company specializes in creating SivaRods, a photothermal device that utilizes heat to irreversibly damage solid tumor tissues. By employing gold nanorods and an infrared light device, Siva Therapeutics offers a therapy that is more selective than traditional chemotherapy, less harmful than radiation, and avoids the risks associated with surgical interventions. The company's mission is to provide safe, minimally invasive, and cost-effective medical device treatments that enhance patient outcomes in the fight against cancer.

3Derm Systems, Inc. is a Boston-based company that specializes in 3D dermatology solutions. Founded in 2011, it has developed a handheld skin imager along with cloud-based software that enables users to capture, store, and transmit high-resolution 3D images of the skin to dermatologists. This innovative system allows non-dermatologists to take clinical-quality images remotely, facilitating efficient monitoring of skin conditions, particularly for patients at risk of skin cancer. By enabling images to be reviewed at medical kiosks and other referral sites, 3Derm helps dermatologists manage high patient volumes while reserving in-office visits for those requiring immediate attention. The company's approach aims to reduce healthcare costs, decrease wait times, and enhance access to dermatological care, allowing patients to monitor their skin from home instead of making frequent, often inconvenient, clinic appointments. 3Derm Systems operates as a subsidiary of Digital Diagnostics, Inc. as of August 2020.

Newfield Design is a Maine, US based company that designs, develops and manufactures communications systems infrastructure. The founders have decades of experience in successful communications system design, development, deployment and management, particularly with Public Safety, Commercial/SMR and Critical Infrastructure communications systems.

Avaxia Biologics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing oral antibody therapeutics. Founded in 2005, the company aims to address gastrointestinal diseases and other serious conditions through its proprietary antibody platform. Its product pipeline includes treatments for inflammatory bowel diseases, celiac disease, necrotizing enterocolitis, radiation syndrome, oral mucositis, and metabolic disorders such as diabetes and obesity. Avaxia Biologics is also engaged in a strategic collaboration with Courtagen Life Sciences, Inc., enhancing its research and development efforts in creating gut-targeted therapeutics. As a clinical-stage organization, Avaxia Biologics is committed to improving patient outcomes by delivering innovative solutions for complex health challenges.

Mosaic Storage Systems, founded in 2011 and based in Nashua, New Hampshire, specializes in digital asset storage services aimed at professional and prosumer photographers. The company provides a platform for users to store digital copies of their photographs on secure servers, facilitating easy access and sharing via the internet. This service allows photographers to manage their digital assets effectively, ensuring their work is both safely stored and readily accessible.

ImmuneXcite is a biopharmaceutical company based in Lexington, Massachusetts, founded in 2007. The company specializes in developing monoclonal antibodies for cancer treatment, utilizing its proprietary mAbXcite platform technology. This innovative approach enhances the efficacy of therapeutic monoclonal antibodies by chemically linking a unique carbohydrate that activates neutrophils, thereby targeting cancer cells for destruction. The research underpinning ImmuneXcite's technology originated from the Whitehead Institute at MIT and has received support from various institutions, including the Massachusetts Technology Transfer Center and the National Cancer Institute. By leveraging both innate and adaptive immune responses, ImmuneXcite aims to create next-generation immune-activating biotherapeutics that selectively treat a wide range of tumor types, ultimately helping to limit tumor growth and metastasis.

Amsel Medical is a medical device company specializing in innovative surgical clamping technology aimed at enhancing surgical and interventional procedures. The company's flagship product, the SCureClamp, utilizes Interdigitation Occlusion Technology (iDOT) to effectively close vessels, including veins and arteries, ensuring secure and reliable occlusion. This device incorporates an anchoring feature that prevents slippage, allowing medical professionals to grasp and occlude vessels of varying sizes, types, and wall thicknesses. Amsel Medical's technology not only facilitates faster healing of blood vessels but also supports minimally invasive delivery methods, making it suitable for both clinical and military applications. The company's advancements in occlusion devices have garnered positive acceptance in initial clinical trials, demonstrating their commitment to improving patient outcomes.

Windgap Medical Inc. is a biotechnology company that specializes in the manufacture of compact epinephrine autoinjectors designed for the treatment of anaphylaxis, a severe allergic reaction. Established in 2011, the company is headquartered in Watertown, Massachusetts. Windgap Medical's innovative auto-injectors are filled with heat-stable epinephrine, which enhances the temperature resilience and shelf life of the medication. This feature allows healthcare providers to effectively administer epinephrine to patients experiencing acute allergy attacks, improving their chances of recovery during critical moments.

Avaxia Biologics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing oral antibody therapeutics. Founded in 2005, the company aims to address gastrointestinal diseases and other serious conditions through its proprietary antibody platform. Its product pipeline includes treatments for inflammatory bowel diseases, celiac disease, necrotizing enterocolitis, radiation syndrome, oral mucositis, and metabolic disorders such as diabetes and obesity. Avaxia Biologics is also engaged in a strategic collaboration with Courtagen Life Sciences, Inc., enhancing its research and development efforts in creating gut-targeted therapeutics. As a clinical-stage organization, Avaxia Biologics is committed to improving patient outcomes by delivering innovative solutions for complex health challenges.

Newfield Design is a Maine, US based company that designs, develops and manufactures communications systems infrastructure. The founders have decades of experience in successful communications system design, development, deployment and management, particularly with Public Safety, Commercial/SMR and Critical Infrastructure communications systems.

Vizibility is a company that specializes in enhancing individuals' online presence through its innovative Mobile Business Card, which serves as a personalized, mobile-friendly website that showcases key information about a person and their organization. This digital card can be easily accessed from any smartphone without the need for an app and can be shared effortlessly using QR codes, NFC mobile wallet cards, and various links. In addition to the Mobile Business Card, Vizibility offers a unique SearchMe button for Google, enabling instant search results, and a PreSearch Wizard that allows users to create and manage custom search results. The company's platform is also integrated and resold by printers and web-to-print vendors, providing them with new features and revenue opportunities. Vizibility holds several U.S. patents related to its technology, with additional patents pending.

Kalion, Inc. is an early-stage industrial biotechnology company based in Milton, Massachusetts, specializing in the development of glucaric acid and S-3 hydroxybutyrolactone (3-HBL) derived from renewable sources. Founded in 2010, the company employs green fermentation technology and advanced fermentation methods utilizing patented microbes to produce these valuable chemicals. Glucaric acid and 3-HBL are recognized as significant value-added chemicals from biomass, with applications in the industrial, pharmaceutical, and nutraceutical sectors. Kalion aims to transform the traditional chemical industry by offering cost-effective access to these compounds, addressing limitations related to their availability and pricing in multi-billion dollar markets.

Testive, Inc. is an educational technology company that offers an online platform for students preparing for standardized tests such as the SAT and ACT. Founded in 2011 and headquartered in Boston, Massachusetts, with an additional office in Durham, North Carolina, Testive combines personalized coaching with advanced technology to enhance the learning experience. The platform utilizes adaptive algorithms to assess students' strengths and weaknesses, thereby providing tailored preparation programs. With over 30,000 users, including students and teachers, Testive's approach is grounded in research developed at MIT, aiming to accelerate the learning feedback cycle and deliver effective one-on-one instruction at a lower cost compared to traditional private tutoring.

ReDigi is the online marketplace for pre-owned digital music and the only Cloud service that verifies whether each music file uploaded for storage was legally acquired from an eligible source. ReDigi's patent pending methods are revolutionary. In addition to the highly sophisticated Verification Engine, the Atomic Cloud transfer system enables the transfer of a digital music file between buyer and seller without copying or file sharing. In addition to these technological breakthroughs, ReDigi supports artists directly through a unique platform that, for the first time in the secondhand music market, grants generous payments from each track sold (and resold) directly to the artist who created it.

Pixability, Inc. is a Boston-based company that specializes in video advertising through its cloud-based software platform. This platform enhances YouTube campaigns by providing tools for insights on placements and keywords, channel management, and campaign optimization. Its flagship product, PixabilityONE, allows brands and agencies to run video campaigns across various platforms, including YouTube and connected TV services like Roku and Hulu. Pixability's technology is designed to ensure brand suitability and maximize the return on video ad spend, offering unique insights into campaign performance. The company is recognized as the only YouTube Measurement Partner certified for Brand Suitability and Contextual Targeting, collaborating with major measurement firms such as DoubleVerify and Nielsen. Pixability’s clientele includes media buyers, agencies, and brands across multiple sectors, reflecting its significant impact on the video advertising landscape since its establishment in 2008.

Bliss Health offers care management services through a network of integrated medical, nursing, and home care services.

CoolChip Technologies Inc. specializes in advanced thermal management solutions, particularly through its proprietary Kinetic Cooling technology. Founded by MIT engineers in 2010 and based in Somerville, Massachusetts, the company focuses on transforming the electronics cooling industry by providing high-performance, low-profile cooling products. These solutions are designed for a wide range of applications, including high-performance computing servers, medical devices, data centers, and consumer electronics. CoolChip's innovative cooling systems enhance thermal performance while minimizing power consumption and acoustic noise, enabling manufacturers to create next-generation products. With a strong intellectual property portfolio, CoolChip continues to lead in developing efficient and compact cooling technologies that meet the demands of modern electronic devices.

Athletic Standard is a company that streamlines the college recruiting process by connecting college coaches with potential athletes at a reduced cost compared to traditional recruiting applications. The platform allows aspiring college athletes to register and test their athletic performance for free, creating a secure database accessible to coaches nationwide. This database includes certified athletic test scores, comprehensive athletic profiles, academic records, and game videos. Additionally, Athletic Standard employs performance-analytics software that harnesses big data and cloud computing to identify top prospects and predict their on-field success, enabling coaching staff to effectively connect with athletic talent across various sports and skill levels.

Scrible, Inc. is a company that provides a cloud-based software solution designed for online reading and research. Founded in 2009 and based in San Mateo, California, Scrible enables users to bookmark, highlight, and annotate web pages directly within their browsers. This service facilitates the organization, sharing, and collaboration of Internet-based research, addressing the inefficiencies of traditional methods such as printing or copying and pasting into documents. Scrible's platform is particularly beneficial for professionals and students who require efficient information management, allowing them to streamline their research processes in various fields, including education and business. By transforming how users engage with online content, Scrible aims to enhance productivity and promote smarter workflows in the digital age.

1908 Brands, founded in 2010 by Steve Savage, is based in Aurora, Colorado, and specializes in manufacturing and marketing natural products. The company offers a diverse portfolio that includes brands such as Boulder Clean, CompoKeeper, thrive TRIBE, Fruitivity Snacks, Schultz’s, Pasta Jay’s, and Yummari. Focused on providing eco-friendly and quality solutions, 1908 Brands produces a range of self-branded and acquired products, including environmentally safe cleaning supplies, composting solutions, and gluten- and allergen-free food items. The company's core values encompass trust, adaptiveness, passion, knowledge, efficiency, and collaboration, all aimed at enhancing the quality of life for its customers through sustainable practices.

Vizibility is a company that specializes in enhancing individuals' online presence through its innovative Mobile Business Card, which serves as a personalized, mobile-friendly website that showcases key information about a person and their organization. This digital card can be easily accessed from any smartphone without the need for an app and can be shared effortlessly using QR codes, NFC mobile wallet cards, and various links. In addition to the Mobile Business Card, Vizibility offers a unique SearchMe button for Google, enabling instant search results, and a PreSearch Wizard that allows users to create and manage custom search results. The company's platform is also integrated and resold by printers and web-to-print vendors, providing them with new features and revenue opportunities. Vizibility holds several U.S. patents related to its technology, with additional patents pending.

ConveyIQ, Inc. offers a cloud-based candidate engagement platform designed to enhance the recruitment process through video technology. Established in 2010 and headquartered in New York City, the company enables recruiters and employers to effectively screen and communicate with candidates. ConveyIQ's platform features a comprehensive communication framework that supports the entire candidate journey, facilitating personalized interactions essential for creating a positive applicant experience. As of August 2019, ConveyIQ operates as a subsidiary of Entelo, Inc.

Respiratory Motion, Inc. is a medical device company based in Waltham, Massachusetts, that specializes in the development and commercialization of respiratory monitoring devices. Founded in 2011, the company offers the ExSpiron, a point-of-care device designed to non-invasively measure critical respiratory parameters such as minute ventilation, tidal volume, and respiratory rate. With FDA clearance for its continuous monitoring systems, Respiratory Motion provides healthcare professionals with real-time data that enhances patient safety and helps in the early detection of respiratory collapse across various patient populations and clinical settings.

RedDress is a medical device company based in Tel Aviv, Israel, founded in 2009. The company specializes in advanced regenerative wound treatment technology designed to enhance the healing process for chronic wounds, including diabetic and foot ulcers. RedDress's innovative products aim to improve patient outcomes by utilizing the body's natural healing mechanisms. The company's focus on wound care and tissue repair positions it as a key player in the field of regenerative medicine, providing healthcare providers with effective solutions for managing challenging wound care cases.

SmartCells, Inc. designs and develops insulin products. It offers SmartInsulin, a self regulating injectable formulation for treating diabetes. The company's polymer-based dosing technology is used for various applications, such as fertility, thyroid, and growth hormone deficiencies; treatments with poor compliance or therapeutic window issues, such as oncology; and drug-device combinations. SmartCells, Inc. was founded in 2003 and is based in Beverly, Massachusetts.

Lessac Technologies Automated Narrator Demonstrates Fully Automatic Expressive Text-to-Speech.

Incentive Targeting specializes in targeted marketing solutions for manufacturers of grocery and consumer products by partnering with retail chains. The company offers a software-as-a-service platform that enables manufacturers to market directly to individual shoppers based on their detailed purchase histories. This service allows for the creation and monitoring of promotional campaigns, utilizing data on offer redemptions at points-of-sale and other relevant information. Promotions can be delivered through various channels, including email, direct mail, or register tape, ensuring a comprehensive reach to consumers within the retail network.

ZetrOZ, LLC is a manufacturer based in Trumbull, Connecticut, specializing in advanced ultrasound technology. Founded in 2009, the company focuses on developing non-invasive medical devices aimed at tissue healing and pain relief for chronic musculoskeletal conditions. ZetrOZ offers a range of products, including the UltrOZ Elite therapeutic systems, wearable veterinary ultrasound systems, and high intensity focused ultrasound systems tailored for biomedical research and industrial applications. Their product lineup also features low-profile ultrasound transducers for therapeutic and diagnostic uses, as well as a variety of applications in industrial monitoring and aquatic environments. The company's innovative generator technology enhances efficiency, portability, and cost-effectiveness, making ultrasound systems more accessible for therapeutic uses such as wound care, surgical procedures, and aesthetic treatments.

Corbus Pharmaceuticals is a clinical-stage pharmaceutical company based in Norwood, Massachusetts, that focuses on developing and commercializing therapeutics for inflammatory and fibrotic diseases. Founded in 2009, the company’s lead product candidate, lenabasum, is a synthetic oral CB2 agonist currently undergoing Phase III clinical trials for systemic sclerosis and dermatomyositis, and Phase IIb trials for systemic lupus erythematosus and cystic fibrosis. In addition to lenabasum, Corbus is developing CRB-4001, a peripherally-restricted CB1 inverse agonist aimed at treating nonalcoholic steatohepatitis and other fibrotic conditions. The company is leveraging a diverse pipeline of drug candidates sourced from a library of over 600 novel compounds targeting the endocannabinoid system. Furthermore, Corbus has established collaborations for the development and commercialization of its products, including a partnership with Kaken Pharmaceutical Co., Ltd. for lenabasum in Japan.

Myomo, Inc. is a medical technology company based in Cambridge, Massachusetts, specializing in wearable medical robotics. Founded in 2004, Myomo develops myoelectric orthotics, particularly the MyoPro, a myoelectric-controlled upper limb brace designed to assist individuals with neuromuscular disorders, including those resulting from strokes, spinal cord injuries, and other neurological conditions. The MyoPro supports weak or paralyzed arms, facilitating daily activities at home and in the community. The company also offers the mPower 1000, a lightweight functional arm brace that aids in restoring movement, as well as a suite of therapeutic programs, including the PERL technique and myGames, which leverage virtual reality to enhance rehabilitation. Myomo's products are distributed through orthotics and prosthetics providers, rehabilitation hospitals, and the Veterans Health Administration, serving medical professionals, patients, and caregivers across the United States.

Daktari Diagnostics, Inc. is a healthcare solutions company based in Cambridge, Massachusetts, founded in 2008. The company specializes in developing portable point-of-care diagnostic platforms aimed at improving disease management worldwide, particularly in resource-poor settings. Its key offerings include the Daktari Virology platform for detecting Hepatitis C and HIV, the Daktari InSight data management service that facilitates connectivity between diagnostic systems and healthcare providers, and the Daktari Sickle Cell solution, which enables the identification of infants with sickle cell disease from a single drop of blood. Daktari's products are designed to provide real-time diagnostic information while ensuring that critical data flows efficiently throughout the healthcare system, ultimately supporting better clinical outcomes and global disease elimination efforts.

Immusoft Corporation is a biotechnology company focused on developing an autologous cell therapy platform aimed at treating a range of human diseases through its proprietary Immune System Programming (ISP) technology. Founded in 2009 and based in Seattle, Washington, Immusoft specializes in modifying the DNA of a patient's immune cells to create biofactories capable of producing gene-encoded medicines, including essential proteins and enzymes that may be missing or defective. The company's innovative approach involves reprogramming B cells, a type of immune cell, which enables them to manufacture and secrete various antibodies. This process not only provides a potential long-term solution for patients but also positions Immusoft at the forefront of biotechnology in addressing rare and infectious diseases.

AisleBuyer is a mobile shopping platform that enhances the in-store retail experience by integrating smartphone technology with traditional retail elements. The company offers a virtual shopping assistant and a mobile self-checkout system, enabling consumers to easily scan product barcodes using their smartphones. This functionality allows shoppers to access detailed product information, read reviews, and find real-time coupons and discounts, all while facilitating in-store purchases without the need to wait in line. AisleBuyer's solutions provide retailers with comprehensive tools to increase sales, lower operational costs, and gain valuable insights into consumer shopping behavior.

JB Therapeutics is a clinical stage biopharmaceutical company focused on developing novel analgesic agents, marking the introduction of a new class of pain relief medications in two decades. The company's lead compound, JBT-101, is a potent agonist of the CB1 and CB2 receptors, demonstrating effectiveness in various animal models for pain and inflammation. JBT-101 has successfully completed a Phase II clinical study targeting chronic refractory neuropathic pain and is currently being explored as a potential disease-modifying treatment for osteoarthritis. Additionally, JBT-101 offers a platform for combination therapies with other anti-inflammatory and analgesic agents, alongside various drug delivery methods, including ointments, gels, topical patches, and timed-release formulations.

ImageRights International specializes in protecting the intellectual property rights of photo agencies and professional photographers by offering intelligent image search and copyright enforcement services. The company enables clients to identify unauthorized uses of their works and assists in registering infringement claims. Notably, ImageRights has automated the copyright registration process with the US Copyright Office, integrating copyright enforcement into the daily workflows of its clients. By providing tools and services that help artists discover misuse of their images, ImageRights empowers them to take action against infringers, ensuring they are compensated for their creative contributions.

CollegeWikis.com is the leading group messaging and information platform for students by students. Since its launch last year, CollegeWikis has become the group messaging platform of choice for over 50,000 students in more than 200 colleges, with over 600,000 topics. On CollegeWikis, students can join groups for their school, courses, dorms, and more; then send and follow group messages to peers. Those messages then become wiki-editable pages on the site, providing information that is always accurate and searchable by others. The original idea for the site came from Founder Joe DiPasquale's experience in business school. He told us: "We had an email list for our class year, through which hundreds of messages were sent per week. But students faced two problems: the absence of group lists that we really wanted, like for our dorm or courses; and all the great content sent out over the list was soon buried in people’s email inboxes. CollegeWikis not only provides these groups but also captures their content."

WebNotes helps people manage the deluge of online content they sift through every day by providing users with a virtual highlighter and sticky note tool that can be used to make annotations directly on any web page. These tools eliminate the need to repeatedly copy & paste information into a word document or e-mail, or sort through hundreds of bookmarks. Users' annotations are automatically saved to their WebNotes accounts for later reference, and can be searched, organized, and shared with others at any point in time.

BrandYourself is an online reputation management platform that assists individuals and businesses in enhancing their digital presence. The company provides tools and services designed to address negative online content, such as outdated divorce records or unflattering social media posts, while promoting positive information that can advance a person's career. In 2012, BrandYourself introduced a DIY online reputation management tool that guides users through monitoring and improving their online image. The platform leverages machine learning, natural language processing, and image recognition to help clients improve their search results by out-ranking negative content with new, favorable information. Additionally, BrandYourself offers professional reputation management services supported by a team of content creators, web developers, social media managers, and brand strategists. The company has received over $6 million in venture capital and has been recognized for its entrepreneurial success, including appearances on national television and accolades from respected publications.

Tikatok is an online platform that enables children under 13 to write, illustrate, and publish their own stories as real books. Founded by two mothers, Tikatok aims to provide a creative outlet for young children, allowing them to self-publish paperback or hardcover books for under $20. The platform features a user-friendly, template-based system called "story sparks," which assists children in starting their writing and illustration projects. Users can upload artwork directly or send it in via mail. Tikatok also offers group packages for schools and libraries, promoting collaborative creativity. The platform is designed with a family-centered approach and includes a well-considered privacy policy to ensure a safe environment for its young users.

Emerginvest is a website which helps investors research international stock markets, and then shows them how they can invest there. Emerginvest (a free service) is connecting investors to hundreds of thousands of undiscovered, international companies by providing data, research, and tools on 150+ world stock exchanges. Emerginvest lets anyone — even those who aren't familiar with world markets — find international stocks to invest in. After a few minutes of browsing, investors can find companies in emerging markets like China, or in frontier markets such as Vietnam or Botswana. Once a user finds an investment, Emerginvest can recommend all of the ways that an investor can own that particular stock—whether through suggesting local, English-speaking brokerages, or domestic vehicles such as mutual funds, ETFs, and ADRs.

Communication services, namely, providing online electronic bulletin boards and chat rooms in the field of general interest.

Incentive Targeting specializes in targeted marketing solutions for manufacturers of grocery and consumer products by partnering with retail chains. The company offers a software-as-a-service platform that enables manufacturers to market directly to individual shoppers based on their detailed purchase histories. This service allows for the creation and monitoring of promotional campaigns, utilizing data on offer redemptions at points-of-sale and other relevant information. Promotions can be delivered through various channels, including email, direct mail, or register tape, ensuring a comprehensive reach to consumers within the retail network.

Oculis Labs Inc. is a cybersecurity company based in Hunt Valley, Maryland, founded in 2007. The firm specializes in developing security software that safeguards computer screens from unauthorized viewing, effectively protecting sensitive information from over-the-shoulder observers. Its flagship product, PrivateEye, employs eye-tracking technology to blur screen content for anyone not directly in front of the display, ensuring that only the intended user can see the information clearly. In addition to its protective capabilities, PrivateEye also generates an audit trail that provides proof of compliance with security protocols. Oculis Labs serves a diverse clientele, including governments, enterprises, original equipment manufacturers (OEMs), and individual consumers around the globe. As of 2015, Oculis Labs operates as a subsidiary of Optio Labs, LLC.

StylePath operates as a shopping recommendation engine focused on fashion, accessories, and home furnishings. Utilizing a patented machine-learning algorithm, the platform filters a wide range of products, including clothing, jewelry, and home decor, based on individual shopper preferences. This personalization enhances the shopping experience by presenting users with items that align with their tastes. Additionally, StylePath features a function called Window Shopping, which curates a continuous stream of recommended products tailored to user interests. By streamlining the discovery process, StylePath aims to simplify the journey for consumers seeking to purchase products that resonate with their personal style.

eSight Corporation develops innovative wearable electronic glasses aimed at enhancing vision for individuals with severe visual impairments, including conditions such as macular degeneration, retinopathy of prematurity, and diabetic retinopathy. The company's flagship product features a high-definition camera and OLED screens to capture and display real-time video, allowing users to adjust visual settings for improved clarity and detail. This technology empowers users to engage in everyday activities and pursue their interests without the limitations imposed by traditional assistive devices. Founded in 2006 and headquartered in Toronto, Canada, eSight also maintains offices in Ottawa, Los Angeles, Nashville, and Switzerland, serving customers primarily in Canada and the United States.

Founded in 1999, XCOR Aerospace is a privately-held corporation based in California, with its headquarters and development facilities situated at the Mojave Spaceport. The company specializes in the research, development, and production of reusable rocket-powered vehicles designed for suborbital and eventually orbital travel. XCOR's offerings include customizable flights supported by dedicated payload integrators, as well as space-focused training programs that involve medical screenings and specialty training missions. Through its innovative rocket-powered vehicles and advanced materials, XCOR aims to enhance the safety and reliability of space missions, thereby increasing opportunities across various markets.

Emovi specializes in advanced knee joint assessment technologies aimed at improving patient quality of life. The company has developed a device that serves as a diagnostic aid for knee injuries and osteoarthritis, providing medical professionals with actionable data on joint movement while weight-bearing. This technology helps in reducing pain, minimizing opioid use, and shortening recovery times for patients. Emovi's commitment to innovation in healthcare is reflected in its focus on delivering high-quality products that enhance the treatment and management of knee conditions.

SmartCells, Inc. designs and develops insulin products. It offers SmartInsulin, a self regulating injectable formulation for treating diabetes. The company's polymer-based dosing technology is used for various applications, such as fertility, thyroid, and growth hormone deficiencies; treatments with poor compliance or therapeutic window issues, such as oncology; and drug-device combinations. SmartCells, Inc. was founded in 2003 and is based in Beverly, Massachusetts.

First, on PawSpot a human profile is included along with a pet profile, and users are encouraged to become “friends”. PawSpot seems to be aiming to provide much needed services to pet owners. In particular, arranging for friends to take care of each other’s pets while away on vacation, and finding local dog parks.

First Light Diagnostics Inc. specializes in the development of automated medical diagnostic products aimed at detecting microbes responsible for healthcare-associated infections. The company is known for its benchtop MultiPath analyzer, which identifies both resistant and sensitive strains of Staphylococcus aureus, as well as various toxins and viruses, making it suitable for hospital clinical microbiology laboratories. Its products address multiple applications, including the screening of blood, surgical, skin, and gastrointestinal infections. By offering rapid and cost-effective testing solutions, First Light Diagnostics meets the increasing demand for accurate diagnostics, which is essential for reducing hospital infection rates. The company's proprietary MultiPath detection technology combines the efficiency of advanced laboratory tests with affordability and ease of use. Founded in 2006 and based in Chelmsford, Massachusetts, First Light Diagnostics was previously known as First Light Biosciences until its name change in January 2019.

Wasabi Sushi Co. operates a chain of Japanese cuisine restaurants, emphasizing simple, flavorful, and healthy dishes. Founded in 2005 and headquartered in Washington, D.C., the company has expanded its presence to include locations in Orlando, Florida; Braintree and Worcester, Massachusetts; and McLean, Virginia. Wasabi focuses on modern Japanese culinary traditions, utilizing fresh ingredients such as raw fish, zesty soy, and seaweed to create vibrant flavors that appeal to a diverse clientele.

The Canary System is a low-powered, laser-based instrument with an integrated intraoral camera that detects the presence of cracks and caries before they are large enough to appear on dental X-rays. The system also generates a patient report that contains an odontogram with Canary numbers, which are color-coded for the examined teeth, along with the dentist’s treatment recommendation. The Canary System’s reports can also be examined by the patient on The Canary Cloud. Launched in 2006, it is based in Toronto, O.N.