Boston Harbor Angels

Astrocyte Pharmaceuticals Inc. is a drug development company focused on creating neuroprotection therapies for various brain injuries, including traumatic brain injuries, concussions, acute ischemic strokes, and neurodegenerative disorders like Alzheimer’s disease. Founded in 2014 and located in Cambridge, Massachusetts, the company is dedicated to demonstrating the neuroprotective benefits of selective astrocyte activation. Its lead product, AST-004, is a novel small molecule designed for acute administration that protects and repairs damaged neurons by selectively stimulating astrocytes. Astrocyte Pharmaceuticals aims to advance innovative therapeutic agents to improve recovery and well-being for patients suffering from brain injuries.

Zylo Therapeutics, Inc. is a life sciences company based in Greenville, South Carolina, specializing in a sustained-release drug delivery system. Founded in 2017, the company has developed a delivery mechanism that employs patented hydrogel-derived nanoparticles, known as Nanopods™, to facilitate the topical administration of difficult-to-deliver therapeutic agents, including nitric oxide. This innovative system enhances drug delivery capabilities and is designed to improve the treatment of various conditions such as lupus, hair loss, joint pain, and burns. By utilizing engineered amorphous silica particles, Zylo Therapeutics aims to provide a controlled and sustained release of medications, thereby enhancing product performance and patient outcomes.

Xeno Biosciences Inc. is a biopharmaceutical company based in Somerville, Massachusetts, founded in 2015. It specializes in developing innovative therapeutics aimed at addressing unmet needs in obesity and related metabolic diseases. The company's lead product, XEN-101, is an oral formulation designed to replicate the microbiome changes associated with Roux-en-Y Gastric Bypass surgery. By delivering molecular oxygen to the lower gut, Xeno Biosciences enables a shift in the gut microbiome, promoting weight loss without the need for surgical intervention. The company's approach represents a novel class of therapeutics that seeks to transform the treatment landscape for obesity.

Enrich Therapeutics Inc. is a biotechnology company based in Worcester, Massachusetts, that specializes in developing innovative single-cell isolation technology for life science research. The company offers LASUM, a technology that enables the selection and isolation of single cells using a microscope, applicable to a variety of cell types including suspension, adherent, and challenging tissue samples. Enrich Therapeutics' solutions enhance scalability and affordability across several applications such as antibody drug discovery, next-generation sequencing (NGS), and the development of adoptive cell therapies. In addition to its core technology, the company provides services in phage display library engineering, affinity-on-demand binder selection, CAR-T cell line development, B-cell isolation, and precision cell isolation for NGS analysis. Founded in 2018, Enrich Therapeutics aims to advance life science research through its cutting-edge tools and methodologies.

Powerplay is a technology company that develops project management software specifically tailored for construction and architectural projects. Their flagship product, PowerplayOS, is a mobile app ecosystem designed to streamline communication between site teams and offices. It facilitates efficient tracking of activities, inventory, and progress, enabling businesses to manage projects more effectively, meet deadlines, and stay within budget.

Zylo Therapeutics, Inc. is a life sciences company based in Greenville, South Carolina, specializing in a sustained-release drug delivery system. Founded in 2017, the company has developed a delivery mechanism that employs patented hydrogel-derived nanoparticles, known as Nanopods™, to facilitate the topical administration of difficult-to-deliver therapeutic agents, including nitric oxide. This innovative system enhances drug delivery capabilities and is designed to improve the treatment of various conditions such as lupus, hair loss, joint pain, and burns. By utilizing engineered amorphous silica particles, Zylo Therapeutics aims to provide a controlled and sustained release of medications, thereby enhancing product performance and patient outcomes.

Founded in 2013, DetraPel is a cleantech company specializing in the synthesis and manufacturing of PFAS-free protective coatings. Its hydrophobic liquid repellent spray safeguards objects from spills and stains.

CytoAgents, Inc. is a clinical-stage biotechnology company based in Pittsburgh, Pennsylvania, established in 2018. The company specializes in developing innovative protein-based drugs aimed at treating viral infectious diseases, particularly focusing on life-threatening symptoms associated with Cytokine Release Syndrome (CRS). CRS is an inflammatory response characterized by an overactive immune system, often linked to conditions such as oncology CAR-T cell therapy and COVID-19. CytoAgents' lead product, GP1681, acts as an agonist of a G-protein coupled receptor and represents a novel therapeutic approach to manage the immune response in patients experiencing cytokine storms. Through its research and development efforts, CytoAgents aims to address significant unmet medical needs across various indications, enhancing treatment efficacy for patients suffering from severe systemic inflammation.

Tunnel is a developer of cloud-based payment software that facilitates real-time global cross-currency payments without transaction fees. Utilizing distributed ledger technology, Tunnel offers its own payment infrastructure, including application programming interfaces and mobile applications. This innovative approach allows both individuals and companies to conduct transactions securely and efficiently, minimizing costs associated with traditional payment methods while enhancing fraud prevention.

Tunnel is a developer of cloud-based payment software that facilitates real-time global cross-currency payments without transaction fees. Utilizing distributed ledger technology, Tunnel offers its own payment infrastructure, including application programming interfaces and mobile applications. This innovative approach allows both individuals and companies to conduct transactions securely and efficiently, minimizing costs associated with traditional payment methods while enhancing fraud prevention.

RevBio is a biotechnology company focused on developing innovative solutions for bone repair. Its flagship product, Tetranite, is an injectable, self-setting, osteoconductive bone adhesive biomaterial designed to bond bone to bone and bone to metal in challenging environments. Tetranite is currently undergoing FDA review for various applications, including oral, craniofacial, orthopedic, and neurosurgical uses. This synthetic adhesive biodegrades over time, being replaced by new bone as part of the natural bone remodeling process, thus serving as a scaffold to promote bone growth. By utilizing this unique material, RevBio aims to reduce the duration and complexity of medical procedures, facilitate more minimally invasive surgeries, and enhance patient outcomes by decreasing pain, recovery time, and overall healthcare costs. The company is actively developing a portfolio of applications tailored for both dental and orthopedic fields.

Astrocyte Pharmaceuticals Inc. is a drug development company focused on creating neuroprotection therapies for various brain injuries, including traumatic brain injuries, concussions, acute ischemic strokes, and neurodegenerative disorders like Alzheimer’s disease. Founded in 2014 and located in Cambridge, Massachusetts, the company is dedicated to demonstrating the neuroprotective benefits of selective astrocyte activation. Its lead product, AST-004, is a novel small molecule designed for acute administration that protects and repairs damaged neurons by selectively stimulating astrocytes. Astrocyte Pharmaceuticals aims to advance innovative therapeutic agents to improve recovery and well-being for patients suffering from brain injuries.

Anubis Bio is a pet health company that develops natural food products to manage digestive issues in animals. Its flagship product, DoggyStat, rapidly resolves diarrhea in dogs and cats by delivering immune factors to the gastrointestinal tract.

KnipBio Inc., established in 2013 and headquartered in Lowell, Massachusetts, specializes in developing sustainable biotechnology solutions for animal nutrition, particularly within the aquaculture industry. The company's flagship product is KnipBio Meal (KBM), a single-cell protein derived from microbe strains that convert abundant, low-cost feedstocks into nutritious alternatives to traditional fishmeal. This innovative approach aims to address real-world challenges in aquaculture feed while promoting responsible and sustainable practices.

Candidly is a company focused on simplifying student debt repayment and refinancing for employers through a software-as-a-service (SaaS) model. Founded by former Google employee, Candidly aims to assist organizations in providing effective benefits that help employees manage and reduce their student debt burdens. By offering innovative solutions, Candidly empowers companies to support their workforce in achieving financial well-being and securing a more stable future.

BrandVerge is a marketplace and workflow platform that connects advertisers with publishers to plan, discover, and activate branded content partnerships at scale. The platform provides an online marketplace and collaboration tools that help advertisers manage marketing programs on demand and bring relevant buyers to publishers, while enabling publishers to increase visibility and grow new business. By streamlining the process from discovery to recommendation, BrandVerge reduces manual work and accelerates activation of branded content opportunities for media companies. Founded in 2017 and based in New York, BrandVerge focuses on helping brands and publishers collaborate efficiently to grow revenues through branded content.

DeepLook is a point-and-click tool that integrates mammography workstations to fit with the radiologist’s workflow.

Astrocyte Pharmaceuticals Inc. is a drug development company focused on creating neuroprotection therapies for various brain injuries, including traumatic brain injuries, concussions, acute ischemic strokes, and neurodegenerative disorders like Alzheimer’s disease. Founded in 2014 and located in Cambridge, Massachusetts, the company is dedicated to demonstrating the neuroprotective benefits of selective astrocyte activation. Its lead product, AST-004, is a novel small molecule designed for acute administration that protects and repairs damaged neurons by selectively stimulating astrocytes. Astrocyte Pharmaceuticals aims to advance innovative therapeutic agents to improve recovery and well-being for patients suffering from brain injuries.

Quthero is focused on developing innovative solutions for post-surgical scarring prevention through a patented gel technology. This gel is designed to restore moisture and mechanical properties of wounds, facilitating effective healing while minimizing scarring, redness, and bruising. By promoting full epithelial restoration, Quthero's products aim to accelerate the closure of skin wounds, thereby reducing the complications and risks associated with slow healing. Their approach targets both cosmetic and medical applications, providing a comprehensive solution for individuals undergoing skin procedures or surgeries.

Astrocyte Pharmaceuticals Inc. is a drug development company focused on creating neuroprotection therapies for various brain injuries, including traumatic brain injuries, concussions, acute ischemic strokes, and neurodegenerative disorders like Alzheimer’s disease. Founded in 2014 and located in Cambridge, Massachusetts, the company is dedicated to demonstrating the neuroprotective benefits of selective astrocyte activation. Its lead product, AST-004, is a novel small molecule designed for acute administration that protects and repairs damaged neurons by selectively stimulating astrocytes. Astrocyte Pharmaceuticals aims to advance innovative therapeutic agents to improve recovery and well-being for patients suffering from brain injuries.

PlaceMe addresses the housing challenges faced by young professionals and graduate students in Boston by offering co-living rental spaces. The company provides fully furnished bedrooms in apartments, which come equipped with essential amenities such as furniture, utilities, high-speed internet, and monthly cleaning of common areas. PlaceMe operates on a flat monthly rent structure and offers flexible lease terms starting at three months, allowing residents to enjoy a convenient and hassle-free living experience.

Xylyx Bio is a pioneering company in the field of biomaterials, dedicated to creating science-based solutions that enhance human health and life. It specializes in developing regenerative biotechnologies, offering tissue-specific extracellular matrix (ECM) substrates, clinically relevant data packages, and compound testing services. These products are designed to support pharmaceutical development, cell biology research, and regenerative medicine, providing scientists with essential components that mimic the natural cell microenvironment. By improving predictive decision-making in drug discovery, Xylyx enables researchers to develop treatments for various medical conditions, particularly focusing on fibrosis, scarring, and cellular repair in skin health and healing.

GoodTwo is an online platform that facilitates fundraising campaigns through group buying deals, enabling individuals, community groups, and nonprofits to generate donations effectively. Users can create a free fundraising page and select up to three pre-negotiated deals from local and national brands, similar to those offered on popular group buying sites. GoodTwo handles all aspects of the campaign, including deal negotiation, fulfillment, and customer service. Fundraisers can leverage their own donor lists to promote these offers, and for each deal sold, GoodTwo donates half of its profits to the fundraising cause. This approach provides a straightforward way for fundraisers to engage their supporters while offering attractive deals to donors.

Gramify is personalized audio greetings that feature the voice of celebrities and fictional characters. These are emotionally-engaging alternatives to print cards and ecards. They are bought online and delivered either through a phone call or through Facebook. They started signing licenses and are negotiating with major brands. The best part is the team which include licensing heavyweights who have done hundreds of deals.

Neuraly, Inc. is a clinical-stage biotechnology company based in Germantown, Maryland, focused on developing innovative treatments for neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. Founded in 2016, the company emerged from research led by prominent neuroscientists and has secured exclusive licenses for key patents related to its drug candidates. Neuraly is advancing several compounds, notably NLY01, a neuroprotective agent designed to inhibit pathological microglial activation, and NLY02 and NLY03, which are blood-brain barrier-penetrating kinase inhibitors. The company's approach aims to address the underlying mechanisms of neurodegeneration by targeting glial cell activity and preventing neuronal cell death, with the ultimate goal of improving the quality of life for patients affected by these debilitating conditions.

NextShift Robotics Inc., founded in 2016 and based in North Billerica, Massachusetts, specializes in the design and development of autonomous mobile robots aimed at enhancing material handling in warehouses and manufacturing environments. The company offers innovative solutions for e-commerce order fulfillment and cellular manufacturing, focusing on efficient workflows that adapt to real-time demands. NextShift's robots are engineered to improve order processing by dynamically adjusting to variations in order volume and shipping priorities, while also facilitating collaboration with warehouse staff. Their systems are characterized by rapid deployment and low maintenance requirements, making them suitable for demanding operational conditions. With a team of experts in material handling and warehouse automation, NextShift Robotics aims to extend the capacity of existing facilities and meet the increasing demands of modern logistics.

Lumo is a developer of a smart air travel application that focuses on managing flight disruptions. The application utilizes predictive analytics to forecast flight delays well in advance, offering users real-time predictions and insights into flight delay patterns. By presenting alternative flight options in the event of delays, Lumo aims to help travelers proactively address potential issues, thereby reducing the costs and inconveniences typically associated with air travel disruptions. The company's commitment to enhancing the travel experience makes it a valuable resource for passengers seeking to navigate the complexities of air travel more effectively.

Fynalist is a recruitment platform founded in 2016 and based in Newton, Massachusetts. It caters to corporate recruiters and talent acquisition professionals by facilitating the discovery of qualified and active candidates. The platform acts as a candidate recommendation engine, allowing users to access vetted candidates recommended by their peers in the recruiting field. In addition to talent search and acquisition, Fynalist offers services such as candidate screening, leadership consulting, and executive coaching, thereby enhancing the efficiency of the recruitment process. This comprehensive approach enables businesses to identify and hire executives with the appropriate professional skills for both full-time and contractual positions.

Landsdowne specializes in developing and commercializing innovative battery technology. Their primary product is a safety-focused solution designed to deactivate button batteries following accidental ingestion, aiming to mitigate the growing health crisis associated with these batteries.

Pyramid Biosciences, Inc. is a biotechnology company based in Waltham, Massachusetts, focused on the discovery and development of targeted therapeutics for disorders regulated by the tropomyosin receptor kinase (TRK) family. The company’s pipeline includes TRK modulators aimed at treating dermatology and oncology disorders linked to dysregulation of the TRK signaling pathway. Notable products in development include PBI-100, which offers anti-itch, anti-inflammatory, and antiproliferative effects for dermatological conditions, and PBI-200, an orally active TRK inhibitor designed to address acquired resistance mutations associated with existing TRK therapies in oncology. Incorporated in 2015, Pyramid Biosciences aims to provide innovative solutions that effectively modulate key signaling pathways, thereby assisting physicians in managing diseases and improving patient outcomes.

Green Piñata LLC is an online subscription service based in Wakefield, Massachusetts, specializing in the rental of non-toxic, educational toys for children under five years old. Founded in 2015, the company provides a platform that allows parents to select toys from a curated catalog made from sustainably sourced materials. Customers can choose the toys they wish to rent, and their children can play with them for as long as desired before returning them. Additionally, Green Piñata offers a custom curriculum guide and a toy selection tool that helps match toys to a child's preferences and developmental needs, ensuring that families have access to high-quality, eco-friendly toys that support learning and play.

Xeno Biosciences Inc. is a biopharmaceutical company based in Somerville, Massachusetts, founded in 2015. It specializes in developing innovative therapeutics aimed at addressing unmet needs in obesity and related metabolic diseases. The company's lead product, XEN-101, is an oral formulation designed to replicate the microbiome changes associated with Roux-en-Y Gastric Bypass surgery. By delivering molecular oxygen to the lower gut, Xeno Biosciences enables a shift in the gut microbiome, promoting weight loss without the need for surgical intervention. The company's approach represents a novel class of therapeutics that seeks to transform the treatment landscape for obesity.

Archer Roose is a global wine brand dedicated to making wine more accessible via innovative packaging like cans and kegs. They focus on sustainability and transparency, offering artisan-quality wines at affordable prices.

Platelet BioGenesis, Inc. is a biotechnology company based in Cambridge, Massachusetts, established in 2014. It specializes in the production of donor-independent human platelets derived from pluripotent stem cells for clinical applications. The company has developed a microfluidic bioreactor that enables the generation of functional platelets at commercial scale from human stem cell cultures. These bioreactor-produced platelets are distributed to hospitals and blood banks, providing essential therapeutic resources to patients globally. Through its innovative approach, Platelet BioGenesis is contributing to advancements in biotechnology and the field of transfusion medicine.

RevBio is a biotechnology company focused on developing innovative solutions for bone repair. Its flagship product, Tetranite, is an injectable, self-setting, osteoconductive bone adhesive biomaterial designed to bond bone to bone and bone to metal in challenging environments. Tetranite is currently undergoing FDA review for various applications, including oral, craniofacial, orthopedic, and neurosurgical uses. This synthetic adhesive biodegrades over time, being replaced by new bone as part of the natural bone remodeling process, thus serving as a scaffold to promote bone growth. By utilizing this unique material, RevBio aims to reduce the duration and complexity of medical procedures, facilitate more minimally invasive surgeries, and enhance patient outcomes by decreasing pain, recovery time, and overall healthcare costs. The company is actively developing a portfolio of applications tailored for both dental and orthopedic fields.

Medumo, Inc. is a healthcare technology company based in Boston, Massachusetts, founded in 2013. It specializes in automating the delivery of timely instructions to patients through its CareTours platform, which utilizes automated messaging via SMS and email. By integrating mobile communication and artificial intelligence, Medumo empowers healthcare organizations to engage patients effectively without requiring additional resources. The platform allows patients to seek medical advice, manage health records, and receive precise instructions, thereby enhancing patient-provider communication. Medumo aims to improve patient preparedness and reduce the administrative burden on healthcare staff, ultimately fostering a more transparent and informed healthcare environment. The company operates as a subsidiary of Koninklijke Philips N.V. since 2019.

Sialix Cancer Research provides cancer susceptibility antibodies and cancer-associated nucleoprotein antibodies for breast cancer. They also offer laser-based photodynamic endoscopic diagnosis using 5-aminolevulinic acid for early gastric adenocarcinoma and gastric adenoma.

Siamab Therapeutics is a biopharmaceutical company based in Newton, Massachusetts, focused on developing therapies for cancers that express abnormal carbohydrates or glycans. The company's technology platform facilitates the discovery of anti-tumor-associated carbohydrate antigen (anti-TACA) therapeutic antibodies. Siamab Therapeutics' pipeline includes ST1, a program targeting a tumor-associated carbohydrate antigen found in various solid tumors such as ovarian, prostate, pancreatic, gastric, and colon cancers. The company has a strategic collaboration with Boehringer Ingelheim and was founded in 2006. Its core technologies were licensed from the laboratory of Ajit Varki, an expert in glycobiology and sialic-acid biochemistry.

Simple Science provides anti-microbial products designed to lead a healthy life. They help people lead healthier lives through healthier products, like their antimicrobial skin therapies that contain no steroids or their household cleaners that contain no harmful chemicals.

Ionica Sciences, Inc. is a diagnostic company based in Ithaca, New York, founded in 2013. It specializes in developing a spectroscopy-based diagnostic platform that employs surface enhanced Raman scattering (SERS) technology. This innovative approach is designed to diagnose a range of diseases, including vector-borne, sexually transmitted, and neurological conditions. Ionica Sciences focuses on creating in-vitro diagnostic assay tests, particularly for Lyme disease and other infectious diseases, allowing medical professionals to detect biologically relevant targets such as pathogens and hormones. By providing accurate and rapid diagnostic solutions, the company aims to enhance clinical decision-making, reduce unnecessary antibiotic usage, and lower healthcare costs associated with misdiagnoses.

CleanFiber, LLC is a manufacturer of cellulose insulation materials designed for use in attics, walls, and floors of both residential and commercial buildings. Founded in 2013 and headquartered in Blasdell, New York, with an additional office in Buffalo, the company specializes in producing high-performance, carbon-negative insulation from recycled corrugated cardboard. This innovative approach not only promotes sustainability but also enables construction companies to build fire-resistant structures while maintaining cost competitiveness. CleanFiber has transitioned from its former name, UltraCell Insulation, LLC, in September 2018, and is currently focused on rapidly scaling up production to meet growing demand in the insulation market.

KnipBio Inc., established in 2013 and headquartered in Lowell, Massachusetts, specializes in developing sustainable biotechnology solutions for animal nutrition, particularly within the aquaculture industry. The company's flagship product is KnipBio Meal (KBM), a single-cell protein derived from microbe strains that convert abundant, low-cost feedstocks into nutritious alternatives to traditional fishmeal. This innovative approach aims to address real-world challenges in aquaculture feed while promoting responsible and sustainable practices.

Siamab Therapeutics is a biopharmaceutical company based in Newton, Massachusetts, focused on developing therapies for cancers that express abnormal carbohydrates or glycans. The company's technology platform facilitates the discovery of anti-tumor-associated carbohydrate antigen (anti-TACA) therapeutic antibodies. Siamab Therapeutics' pipeline includes ST1, a program targeting a tumor-associated carbohydrate antigen found in various solid tumors such as ovarian, prostate, pancreatic, gastric, and colon cancers. The company has a strategic collaboration with Boehringer Ingelheim and was founded in 2006. Its core technologies were licensed from the laboratory of Ajit Varki, an expert in glycobiology and sialic-acid biochemistry.

Avaxia Biologics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing oral antibody therapeutics for a range of gastrointestinal diseases. Founded in 2005, the company utilizes a proprietary antibody platform to create treatments for conditions such as inflammatory bowel disease, celiac disease, necrotizing enterocolitis, radiation syndrome, oral mucositis, and type 2 diabetes. By concentrating on gut-targeted therapeutics, Avaxia aims to improve treatment options for patients suffering from these serious ailments. The company has established a strategic collaboration with Courtagen Life Sciences to enhance its product development efforts. Avaxia Biologics operates as a subsidiary of Circle33 LLC.

Blurr is a social media platform that combines photo sharing, gamification, and filters. Users can 'blur' photos and set like requirements to unlock them, encouraging engagement and curation.

Premama is a company that specializes in developing prenatal nutritional supplements aimed at improving the health of expectant women. Its flagship product, a doctor-recommended daily prenatal multivitamin in powder form, is designed for easy mixing into cold beverages, yogurt, or smoothies. The formulation includes essential nutrients such as DHA, folic acid, and vitamin B6, which help alleviate symptoms of morning sickness while enhancing overall nutritional status during pregnancy. Premama's products are vegan, gluten-free, and free from genetically modified organisms (non-GMO), addressing common concerns such as iron-induced constipation. The company's offerings, including the Complete, Essentials, and Plus formulas, are available at major retailers like Target and Amazon, as well as specialty vitamin and health food stores.

Siva Therapeutics Inc. is a biotechnology company focused on developing innovative nanotechnology-based treatments for cancer. Founded in 2011 and based in Boulder, Colorado, the company has created SivaRods, a photothermal device that utilizes gold nanorods and infrared light to generate therapeutic heat within solid tumors. This approach aims to irreversibly damage tumor tissues in a manner that is more selective than traditional chemotherapy, less destructive than radiation, and avoids the risks associated with surgical interventions. By prioritizing safety, practicality, and cost-effectiveness, Siva Therapeutics seeks to enhance patient outcomes in the fight against cancer.

Avaxia Biologics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing oral antibody therapeutics for a range of gastrointestinal diseases. Founded in 2005, the company utilizes a proprietary antibody platform to create treatments for conditions such as inflammatory bowel disease, celiac disease, necrotizing enterocolitis, radiation syndrome, oral mucositis, and type 2 diabetes. By concentrating on gut-targeted therapeutics, Avaxia aims to improve treatment options for patients suffering from these serious ailments. The company has established a strategic collaboration with Courtagen Life Sciences to enhance its product development efforts. Avaxia Biologics operates as a subsidiary of Circle33 LLC.

Siva Therapeutics Inc. is a biotechnology company focused on developing innovative nanotechnology-based treatments for cancer. Founded in 2011 and based in Boulder, Colorado, the company has created SivaRods, a photothermal device that utilizes gold nanorods and infrared light to generate therapeutic heat within solid tumors. This approach aims to irreversibly damage tumor tissues in a manner that is more selective than traditional chemotherapy, less destructive than radiation, and avoids the risks associated with surgical interventions. By prioritizing safety, practicality, and cost-effectiveness, Siva Therapeutics seeks to enhance patient outcomes in the fight against cancer.

3Derm Systems, Inc., based in Boston, Massachusetts, is a pioneering company in 3D dermatology that provides a specialized handheld skin imager and cloud-based software designed for capturing, storing, and transmitting high-resolution 3D images of the skin. Established in 2011, the company enables non-dermatologists to take clinical-quality skin images remotely, facilitating efficient monitoring of skin lesions by dermatologists. This innovative approach reduces healthcare costs, shortens wait times, and enhances access to dermatological care, particularly for the two million Americans diagnosed with skin cancer annually. By allowing patients to capture images from the comfort of their homes and upload them for review, 3Derm helps prioritize in-office appointments for those with more concerning conditions. The company's technology aims to transform teledermatology, offering a cost-effective solution that maintains the continuity of care with local dermatologists while ensuring high diagnostic quality. As of August 2020, 3Derm operates as a subsidiary of Digital Diagnostics, Inc.

Newfield Design is a Maine, US based company that designs, develops and manufactures communications systems infrastructure. The founders have decades of experience in successful communications system design, development, deployment and management, particularly with Public Safety, Commercial/SMR and Critical Infrastructure communications systems.

Avaxia Biologics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing oral antibody therapeutics for a range of gastrointestinal diseases. Founded in 2005, the company utilizes a proprietary antibody platform to create treatments for conditions such as inflammatory bowel disease, celiac disease, necrotizing enterocolitis, radiation syndrome, oral mucositis, and type 2 diabetes. By concentrating on gut-targeted therapeutics, Avaxia aims to improve treatment options for patients suffering from these serious ailments. The company has established a strategic collaboration with Courtagen Life Sciences to enhance its product development efforts. Avaxia Biologics operates as a subsidiary of Circle33 LLC.

Mosaic Storage Systems is a company based in Nashua, New Hampshire, founded in 2011. It specializes in providing digital asset storage services tailored for professional and prosumer photographers. The company's services involve taking digital copies of photographs, storing them on secure servers, and making them accessible via the internet. This enables users to store and share their photographs securely, ensuring that their valuable assets are protected and easily manageable.

ImmuneXcite, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, specializing in the development of monoclonal antibodies for cancer treatment. Founded in 2007, the company utilizes its proprietary mAbXcite platform technology to enhance the efficacy of therapeutic monoclonal antibodies. This innovative approach involves chemically linking a unique carbohydrate, initially discovered at the Whitehead Institute at MIT, to monoclonal antibodies, thereby activating neutrophils to target and destroy cancer cells. ImmuneXcite's focus is on leveraging both innate and adaptive immune responses to create next-generation immune-activating biotherapeutics that address a wide range of tumor types, aiming to limit tumor growth and metastasis effectively. The company's research and development efforts have garnered support from various esteemed institutions and organizations, including the Massachusetts Technology Transfer Center and the National Cancer Institute.

Amsel Medical is a medical device company specializing in innovative surgical clamping technology tailored for surgical and interventional procedures. The company's flagship product, the SCureClamp, incorporates Interdigitation Occlusion Technology (iDOT) to securely close vessels such as veins and arteries. Its design features an anchoring mechanism that prevents slippage, ensuring stability during medical procedures. Amsel Medical's devices facilitate the occlusion of vessels of varying sizes and wall thicknesses, promoting faster healing and enhancing treatment efficacy. The company serves both clinical and military markets, demonstrating a commitment to advancing minimally invasive techniques in medical care.

Founded in 2011, WindGap Medical specializes in the development and manufacturing of compact epinephrine autoinjectors for treating anaphylaxis. Headquartered in Watertown, Massachusetts.

Avaxia Biologics, Inc. is a biopharmaceutical company based in Lexington, Massachusetts, focused on developing oral antibody therapeutics for a range of gastrointestinal diseases. Founded in 2005, the company utilizes a proprietary antibody platform to create treatments for conditions such as inflammatory bowel disease, celiac disease, necrotizing enterocolitis, radiation syndrome, oral mucositis, and type 2 diabetes. By concentrating on gut-targeted therapeutics, Avaxia aims to improve treatment options for patients suffering from these serious ailments. The company has established a strategic collaboration with Courtagen Life Sciences to enhance its product development efforts. Avaxia Biologics operates as a subsidiary of Circle33 LLC.

Newfield Design is a Maine, US based company that designs, develops and manufactures communications systems infrastructure. The founders have decades of experience in successful communications system design, development, deployment and management, particularly with Public Safety, Commercial/SMR and Critical Infrastructure communications systems.

Vizibility enables individuals and organizations to create and share mobile-friendly business cards, enhancing professional presence online. Its platform integrates with printers and web-to-print vendors, offering new features and revenue streams.

Kalion, Inc. is an early-stage industrial biotechnology company based in Milton, Massachusetts, focused on developing glucaric acid and S-3-hydroxybutyrolactone (3-HBL) from renewable sources. Established in 2010, Kalion utilizes green fermentation technology and advanced fermentation methods, employing patented microbes developed through proprietary synthetic biology techniques. The company's innovative approach aims to provide low-cost access to these important molecules, which have significant applications in the industrial chemical, pharmaceutical, and nutraceutical industries. Glucaric acid and 3-HBL have been recognized as key value-added chemicals derived from biomass, with potential in multi-billion dollar markets that are currently constrained by high costs and limited availability. Kalion's mission is to transform the traditional chemical industry by offering sustainable alternatives to oil-based materials, thereby promoting environmental sustainability and chemical purity.

Testive, Inc. is an education technology company that specializes in online test preparation for students aiming to improve their scores on the SAT and ACT. Founded in 2011 and headquartered in Boston, Massachusetts, with an additional office in Durham, North Carolina, Testive offers personalized preparation programs by pairing students with coaches. The platform leverages adaptive algorithms to assess students' strengths and weaknesses, facilitating a tailored learning experience. Developed initially at MIT, Testive's approach emphasizes efficient feedback cycles to enhance learning outcomes. Over 30,000 students and educators have utilized Testive’s innovative technology to assist them in their test preparation journeys, making it a leader in the field of educational products that integrate technology and personalized instruction.

ReDigi is the online marketplace for pre-owned digital music and the only Cloud service that verifies whether each music file uploaded for storage was legally acquired from an eligible source. ReDigi's patent pending methods are revolutionary. In addition to the highly sophisticated Verification Engine, the Atomic Cloud transfer system enables the transfer of a digital music file between buyer and seller without copying or file sharing. In addition to these technological breakthroughs, ReDigi supports artists directly through a unique platform that, for the first time in the secondhand music market, grants generous payments from each track sold (and resold) directly to the artist who created it.

Pixability is a data and technology company that provides a cloud-based video advertising platform for brands and their agencies to optimize campaigns across YouTube, YouTube on TV, and connected TV inventory. Its proprietary platform, PixabilityONE, helps ensure brand suitability, maximize return on video ad spend, and deliver actionable insights not available elsewhere. The platform offers tools for campaign management, including creation, benchmarking, testing, optimization, and reporting, as well as channel management and performance analytics. BrandTrack is a measurement solution that helps brands assess YouTube brand performance and adjust strategies. Pixability serves media buyers, agencies, in-house brand teams, and marketers, with clients and partners globally. Founded in 2008 and headquartered in Boston, the company maintains additional offices in New York, San Francisco, Chicago, and London.

Bliss Health offers care management services through a network of integrated medical, nursing, and home care services.

CoolChip Technologies Inc. is a specialized provider of thermal management solutions, focusing on Kinetic Cooling technology to enhance the cooling of electronic devices. Founded by MIT engineers in 2010 and based in Somerville, Massachusetts, the company develops high-performance and low-profile coolers tailored for high-performance computing servers, medical devices, data centers, and consumer electronics. CoolChip's innovative cooling systems enable devices such as phones, tablets, and laptops to efficiently dissipate heat with minimal power consumption, improving thermal performance while maintaining compact form factors and low noise levels. The company holds a significant portfolio of intellectual property, positioning it as a leader in transforming the electronics cooling industry and allowing manufacturers to create next-generation products.

Athletic Standard is a company focused on streamlining the college recruiting process for athletes and coaches. By offering a performance-analytics platform, it connects college coaches with potential athletes at a significantly lower cost than traditional recruiting applications. The platform allows athletes to register for free, creating a secure database accessible to coaches nationwide. This database includes certified athletic test scores and comprehensive athletic profiles, which encompass academic records and game videos. Utilizing advanced technologies such as big data and cloud computing, Athletic Standard aims to identify top athletic talent and predict their on-field success, thereby redefining the landscape of sport economics and enhancing the recruiting experience for both athletes and coaching staff.

scrible, Inc. is a company that specializes in online reading and research software, allowing users to bookmark and annotate web pages in the cloud. Founded in 2009 and headquartered in San Mateo, California, scrible offers a web-based service that facilitates the highlighting, annotating, and organizing of Internet research. This platform enables users to save, share, and collaboratively manage their findings directly in various web browsers, providing a modern solution to outdated research methods such as printing or copying and pasting. By transforming how individuals conduct and manage web-based research, scrible aims to enhance the efficiency of information flow and analysis, making it particularly beneficial for professionals in fast-paced environments. The company's mission focuses on improving the way people work and interact with online information in the digital age.

1908 Brands, founded in 2010 by Steve Savage, is based in Aurora, Colorado, and specializes in manufacturing and marketing natural products. The company offers a diverse portfolio that includes brands such as Boulder Clean, CompoKeeper, thrive TRIBE, Fruitivity Snacks, Schultz’s, Pasta Jay’s, and Yummari. Focused on providing eco-friendly and quality solutions, 1908 Brands produces a range of self-branded and acquired products, including environmentally safe cleaning supplies, composting solutions, and gluten- and allergen-free food items. The company's core values encompass trust, adaptiveness, passion, knowledge, efficiency, and collaboration, all aimed at enhancing the quality of life for its customers through sustainable practices.

Vizibility enables individuals and organizations to create and share mobile-friendly business cards, enhancing professional presence online. Its platform integrates with printers and web-to-print vendors, offering new features and revenue streams.

ConveyIQ, Inc. is a New York-based company that offers a cloud-based candidate engagement platform designed to enhance the recruitment process. Established in 2010, ConveyIQ enables recruiters and employers to effectively screen and communicate with candidates through innovative video technology. The platform provides a comprehensive communication framework that supports the entire candidate journey, ensuring personalized interactions that contribute to a positive applicant experience. As of August 2019, ConveyIQ operates as a subsidiary of Entelo, Inc.

Respiratory Motion, Inc. is a medical device company headquartered in Waltham, Massachusetts, that specializes in respiratory monitoring systems. Established in 2011, the company focuses on the development and commercialization of innovative devices designed to monitor respiratory variation and vital respiratory parameters. Its flagship product, ExSpiron, is a point-of-care device that non-invasively measures minute ventilation, tidal volume, and respiratory rate, providing physicians with critical data to enhance patient safety and outcomes. Respiratory Motion's technology enables continuous monitoring across diverse patient populations and clinical environments, offering early warnings of potential respiratory collapse. The company's systems have received FDA clearance, underscoring their commitment to advancing respiratory health care.

RedDress is a medical device company based in Tel Aviv, Israel, founded in 2009. It specializes in developing advanced regenerative wound treatment technologies designed to enhance the wound healing process. The company focuses on addressing chronic wounds, including diabetic and foot ulcers, by offering a product that utilizes the body's natural healing capabilities. RedDress aims to improve patient outcomes by providing healthcare providers with innovative solutions that facilitate effective wound care and tissue repair across various healthcare settings.

SmartCells, Inc. designs and develops insulin products. It offers SmartInsulin, a self regulating injectable formulation for treating diabetes. The company's polymer-based dosing technology is used for various applications, such as fertility, thyroid, and growth hormone deficiencies; treatments with poor compliance or therapeutic window issues, such as oncology; and drug-device combinations. SmartCells, Inc. was founded in 2003 and is based in Beverly, Massachusetts.

Lessac Technologies Automated Narrator Demonstrates Fully Automatic Expressive Text-to-Speech.

Incentive Targeting is a company that collaborates with retail chains to offer targeted marketing services to manufacturers of grocery and consumer products. Through its platform, manufacturers can directly market to individual shoppers within the entire retail network, utilizing each person's detailed purchase history. The company facilitates promotions through various channels such as email, direct mail, or register tape. Additionally, Incentive Targeting provides a software-as-a-service platform that enables manufacturers to create and monitor campaigns using data on offer redemptions at points-of-sale and other relevant information.

ZetrOZ specializes in innovative ultrasound technology. It manufactures and delivers therapeutic systems, including veterinary wearable ultrasound devices, high-intensity focused ultrasound systems for biomedical research, and various transducer control systems. The company's products cater to applications such as physiotherapy, drug delivery, ultrasonic sealing, cleaning, and sterilization. ZetrOZ was founded in 2009 and is headquartered in Trumbull, Connecticut.

Founded in 2009, Corbus Pharmaceuticals is a clinical-stage company focused on developing and commercializing therapeutics for rare, chronic, and serious inflammatory and fibrotic diseases. Its lead product candidate, lenabasum, is an oral endocannabinoid drug currently in Phase III trials for systemic sclerosis and dermatomyositis, among other indications.

Myomo designs, develops, and produces myoelectric orthotics for individuals with neuromuscular disorders, enabling functional activities of daily living. Its flagship product, MyoPro, is a myoelectric-controlled upper limb brace orthosis used to support weak or paralyzed arms. Myomo serves medical professionals, patients, and caregivers in the United States.

Daktari Diagnostics, Inc. is a healthcare solutions company based in Cambridge, Massachusetts, focused on developing portable point-of-care diagnostic platforms to enhance disease management globally. Founded in 2008, the company offers several innovative products, including Daktari Virology for the detection of Hepatitis C and HIV, Daktari InSight, a cloud-based data management service, and Daktari Sickle Cell, which identifies infants with sickle cell disease from a single drop of blood. Daktari’s technology is designed specifically for resource-poor markets, featuring built-in wireless connectivity that facilitates real-time data sharing among healthcare providers. By delivering critical diagnostic information efficiently, Daktari aims to improve clinical outcomes and support global health initiatives. The company's commitment to affordability and quality ensures that its products are accessible to healthcare professionals and patients worldwide.

Immusoft Corporation is a biotechnology company focused on developing an autologous cell therapy platform aimed at treating a range of human diseases through its proprietary Immune System Programming (ISP) technology. Founded in 2009 and based in Seattle, Washington, Immusoft specializes in modifying the DNA of a patient's immune cells to create biofactories capable of producing gene-encoded medicines, including essential proteins and enzymes that may be missing or defective. The company's innovative approach involves reprogramming B cells, a type of immune cell, which enables them to manufacture and secrete various antibodies. This process not only provides a potential long-term solution for patients but also positions Immusoft at the forefront of biotechnology in addressing rare and infectious diseases.

AisleBuyer is a mobile shopping platform that enhances the in-store retail experience by integrating smartphone technology with traditional retail practices. The company offers a virtual shopping assistant and a mobile self-checkout system, enabling consumers to scan product barcodes using their smartphones to access detailed product information, reviews, and real-time discounts. This innovative approach allows shoppers to complete purchases directly from their devices, eliminating the need to wait in line. AisleBuyer provides retailers with a comprehensive solution designed to boost sales, reduce operational costs, and deliver valuable insights into consumer shopping behavior.

JB Therapeutics is a clinical-stage biopharmaceutical company focused on developing innovative analgesic agents, marking a significant advancement in pain management. The company’s lead compound, JBT-101, is a potent agonist of the CB1 and CB2 receptors, demonstrating efficacy in various animal models for pain and inflammation. It has successfully completed a Phase II clinical study targeting chronic refractory neuropathic pain and is currently being explored as a potential disease-modifying treatment for osteoarthritis. In addition to its primary indications, JBT-101 serves as a versatile platform for potential combination therapies with other anti-inflammatory and analgesic agents, as well as diverse drug delivery methods, including topical ointments, gels, patches, and timed-release formulations.

ImageRights provides image piracy protection and copyright enforcement services for photo agencies and professional photographers worldwide, helping protect intellectual property and secure compensation for unauthorized use. The company offers intelligent image search, automated copyright registration with the US Copyright Office, and enforcement integrated into clients' daily workflows. It helps artists discover misuse, register infringement claims, and register the copyrights of their images, enabling action against individuals and organizations that misuse visuals across the global market.

CollegeWikis.com is the leading group messaging and information platform for students by students. Since its launch last year, CollegeWikis has become the group messaging platform of choice for over 50,000 students in more than 200 colleges, with over 600,000 topics. On CollegeWikis, students can join groups for their school, courses, dorms, and more; then send and follow group messages to peers. Those messages then become wiki-editable pages on the site, providing information that is always accurate and searchable by others. The original idea for the site came from Founder Joe DiPasquale's experience in business school. He told us: "We had an email list for our class year, through which hundreds of messages were sent per week. But students faced two problems: the absence of group lists that we really wanted, like for our dorm or courses; and all the great content sent out over the list was soon buried in people’s email inboxes. CollegeWikis not only provides these groups but also captures their content."

WebNotes helps people manage the deluge of online content they sift through every day by providing users with a virtual highlighter and sticky note tool that can be used to make annotations directly on any web page. These tools eliminate the need to repeatedly copy & paste information into a word document or e-mail, or sort through hundreds of bookmarks. Users' annotations are automatically saved to their WebNotes accounts for later reference, and can be searched, organized, and shared with others at any point in time.

BrandYourself is a company that specializes in online reputation management, offering tools and services designed to enhance individuals' online presence. Established in 2012, it was the first to launch a DIY reputation management tool that guides users through the process of monitoring and improving their digital footprint. The platform enables clients to identify and address negative online content, such as unwanted personal records or unflattering social media posts, while simultaneously promoting positive information that can advance their careers. Utilizing advanced technologies like machine learning and natural language processing, BrandYourself helps users create new content and websites to out-rank negative search results. In addition to its DIY tools, the company provides professional reputation management services, supported by a team of content creators, web developers, and brand strategists. BrandYourself has received recognition from various institutions, including accolades from Entrepreneur Magazine and appearances on the television show Shark Tank, where it declined a significant investment offer.

Tikatok is an online platform designed for children to write, illustrate, and publish their own stories into real books. Founded by two mothers who recognized the importance of fostering creativity in young children, Tikatok allows kids to self-publish their work as paperback or hardcover books for less than $20. Utilizing a template-based system called "story sparks," children can easily begin crafting their narratives and artwork, which can be uploaded or mailed to the site. Tikatok also offers packages for schools and libraries to facilitate group orders. The platform emphasizes family involvement and maintains a robust privacy policy, ensuring a safe environment for children under 13 to express themselves and share their original stories.

Emerginvest is a website which helps investors research international stock markets, and then shows them how they can invest there. Emerginvest (a free service) is connecting investors to hundreds of thousands of undiscovered, international companies by providing data, research, and tools on 150+ world stock exchanges. Emerginvest lets anyone — even those who aren't familiar with world markets — find international stocks to invest in. After a few minutes of browsing, investors can find companies in emerging markets like China, or in frontier markets such as Vietnam or Botswana. Once a user finds an investment, Emerginvest can recommend all of the ways that an investor can own that particular stock—whether through suggesting local, English-speaking brokerages, or domestic vehicles such as mutual funds, ETFs, and ADRs.

Communication services, namely, providing online electronic bulletin boards and chat rooms in the field of general interest.

Incentive Targeting is a company that collaborates with retail chains to offer targeted marketing services to manufacturers of grocery and consumer products. Through its platform, manufacturers can directly market to individual shoppers within the entire retail network, utilizing each person's detailed purchase history. The company facilitates promotions through various channels such as email, direct mail, or register tape. Additionally, Incentive Targeting provides a software-as-a-service platform that enables manufacturers to create and monitor campaigns using data on offer redemptions at points-of-sale and other relevant information.

Oculis Labs Inc. is a cybersecurity software company based in Hunt Valley, Maryland, founded in 2007. The company specializes in screen protection technology that safeguards sensitive information from unauthorized viewing. Its flagship product, PrivateEye, utilizes advanced eye-tracking technology to ensure that only the intended user can clearly see the content displayed on the screen, while blurring it for onlookers. This innovative approach not only enhances privacy but also generates an audit trail for compliance purposes. Oculis Labs serves a diverse clientele, including governments, enterprises, original equipment manufacturers (OEMs), and individual consumers across the globe. As of April 2015, Oculis Labs operates as a subsidiary of Optio Labs, LLC.

StylePath is a shopping recommendation engine focused on fashion, accessories, and home furnishings. Utilizing a patented machine-learning algorithm, the platform analyzes shoppers' tastes and preferences to provide personalized product suggestions. In addition to its core recommendation features, StylePath offers a unique service called Window Shopping, which curates a continuous stream of items tailored to individual interests. This approach enhances the shopping experience by enabling consumers to discover products more aligned with their personal style. Through its innovative technology, StylePath aims to streamline the shopping process and help users find items that resonate with their preferences.

eSight Corporation develops innovative wearable electronic glasses aimed at enhancing vision for individuals with severe visual impairments, including conditions such as macular degeneration, retinopathy of prematurity, and diabetic retinopathy. The company's flagship product features a high-definition camera and OLED screens to capture and display real-time video, allowing users to adjust visual settings for improved clarity and detail. This technology empowers users to engage in everyday activities and pursue their interests without the limitations imposed by traditional assistive devices. Founded in 2006 and headquartered in Toronto, Canada, eSight also maintains offices in Ottawa, Los Angeles, Nashville, and Switzerland, serving customers primarily in Canada and the United States.

Founded in 1999, XCOR Aerospace is a privately-held corporation based in Mojave, California, at the Mojave Spaceport and Civilian Aerospace Test Center. The company specializes in the research, development, and production of reusable rocket-powered vehicles designed for suborbital and future orbital travel. XCOR's innovative propulsion systems enhance the viability of space missions and cater to a variety of markets. The company offers customizable flight opportunities with support from dedicated payload integrators, as well as space-focused training programs that include medical screenings and specialized missions. XCOR aims to provide safer, more reliable, and reusable space travel solutions through advanced materials and engineering techniques.

Emovi specializes in advanced knee joint assessment technologies aimed at improving patient quality of life. The company has developed a device that serves as a diagnostic aid for knee injuries and osteoarthritis, providing medical professionals with actionable data on joint movement while weight-bearing. This technology helps in reducing pain, minimizing opioid use, and shortening recovery times for patients. Emovi's commitment to innovation in healthcare is reflected in its focus on delivering high-quality products that enhance the treatment and management of knee conditions.

SmartCells, Inc. designs and develops insulin products. It offers SmartInsulin, a self regulating injectable formulation for treating diabetes. The company's polymer-based dosing technology is used for various applications, such as fertility, thyroid, and growth hormone deficiencies; treatments with poor compliance or therapeutic window issues, such as oncology; and drug-device combinations. SmartCells, Inc. was founded in 2003 and is based in Beverly, Massachusetts.

First, on PawSpot a human profile is included along with a pet profile, and users are encouraged to become “friends”. PawSpot seems to be aiming to provide much needed services to pet owners. In particular, arranging for friends to take care of each other’s pets while away on vacation, and finding local dog parks.

First Light Diagnostics Inc. is a medical diagnostics company focused on developing automated products for the rapid detection of pathogens responsible for healthcare-associated infections. Based in Chelmsford, Massachusetts, the company offers a benchtop MultiPath analyzer, which is designed for hospital clinical microbiology laboratories and can identify both resistant and sensitive strains of Staphylococcus aureus, as well as various toxins and viruses. Their innovative diagnostic solutions address the increasing demand for accurate and cost-effective testing, which has been shown to significantly reduce hospital infection rates. First Light's proprietary MultiPath detection technology combines the performance of advanced laboratory tests with enhanced affordability and user-friendliness. By providing antimicrobial susceptibility tests that deliver results within hours, the company enables healthcare professionals to administer appropriate antibiotic treatments quickly, ultimately saving lives, reducing healthcare costs, and improving antibiotic stewardship. First Light Diagnostics was incorporated in 2006 and was formerly known as First Light Biosciences Inc. before its name change in January 2019.

Wasabi Sushi Co. operates a chain of Japanese cuisine restaurants, emphasizing simple, flavorful, and healthy dishes. Founded in 2005 and headquartered in Washington, D.C., the company has expanded its presence to include locations in Orlando, Florida; Braintree and Worcester, Massachusetts; and McLean, Virginia. Wasabi focuses on modern Japanese culinary traditions, utilizing fresh ingredients such as raw fish, zesty soy, and seaweed to create vibrant flavors that appeal to a diverse clientele.

The Canary System is a low-powered, laser-based instrument with an integrated intraoral camera that detects the presence of cracks and caries before they are large enough to appear on dental X-rays. The system also generates a patient report that contains an odontogram with Canary numbers, which are color-coded for the examined teeth, along with the dentist’s treatment recommendation. The Canary System’s reports can also be examined by the patient on The Canary Cloud. Launched in 2006, it is based in Toronto, O.N.