Breakout Ventures

EnPlusOne Biosciences specializes in developing an enzymatic-based RNA synthesis platform designed to overcome limitations of traditional chemical synthesis methods. Their innovative approach aims to facilitate large-scale production and expand accessibility to diverse nucleotide modifications for emerging RNA therapeutics.

Copernic Catalysts is a company focused on developing sustainable chemical catalysts and processes aimed at reducing the carbon footprint across various industries. The firm designs innovative zero- and low-carbon technologies that align with the current economic landscape of the chemical sector. Its advanced catalysts and processes support the production of sustainable chemicals and synthetic fuels, helping clients enhance energy efficiency, lower production costs, and access affordable zero-carbon chemicals. Through these efforts, Copernic Catalysts contributes to a more sustainable future in chemical manufacturing.

Passkey Therapeutics is pioneering a new class of medicines, Synergistic Multifunctional Therapeutics (SMThs). It is designed to address complex diseases by targeting rare combinations of proteins that work together.

CytoVale is a medical technology company based in San Francisco that develops biomarkers derived from the mechanical properties of single cells. The company uses microfluidics to route and probe cells, enabling the measurement of multiple biophysical indicators at once. Its technology aims to advance early detection of immune-mediated diseases and sepsis through the analysis of cell mechanics and machine learning. By translating biophysical signals into diagnostic information, CytoVale seeks to improve diagnostic accuracy, support timely treatment decisions, and reduce healthcare costs.

TFC Therapeutics is a biotechnology company focused on creating innovative biologics aimed at addressing critical factors in cancer recurrence and metastasis. The company develops technology that employs monoclonal antibodies designed to specifically bind to receptors on tumor-initiating cells, known as TMH cells. This targeted approach activates the immune system to effectively destroy these cells, offering new treatment possibilities for cancer within the healthcare sector. Through its research and development efforts, TFC Therapeutics seeks to contribute significantly to advancements in cancer therapy.

A-Alpha Bio, Inc. is a biotechnology company specializing in synthetic biology and advanced quantitative measurement of protein interactions to facilitate drug development. Founded in 2017 and headquartered in Seattle, Washington, the company offers its proprietary AlphaSeq platform, which enables high-throughput mapping of protein-protein interactions. This technology allows for the simultaneous identification and quantification of interactions among thousands of protein pairs, streamlining the drug discovery process by aiding in the identification of potential drug targets and enhancing the understanding of disease mechanisms. By providing biologics and molecular glue discovery and optimization services, A-Alpha Bio supports pharmaceutical companies in optimizing binding and specificity to multiple target proteins. The team comprises synthetic biologists, structural biologists, and next-generation sequencing experts dedicated to overcoming challenges in the drug development process.

Parallel Bio is a biotechnology company focused on advancing the discovery and development of immunotherapies. The company's platform integrates best-in-class human immune organoids with computational methods to provide deep insights into human health and disease. This approach aims to overcome current barriers in immunotherapy research, accelerating the path to effective treatments. Parallel Bio's tools are designed to enhance the development of various therapies, including cell therapies, antibody therapies, and vaccines, offering medical professionals novel perspectives on human biology.

EnPlusOne Biosciences specializes in developing an enzymatic-based RNA synthesis platform designed to overcome limitations of traditional chemical synthesis methods. Their innovative approach aims to facilitate large-scale production and expand accessibility to diverse nucleotide modifications for emerging RNA therapeutics.

Canaery is developing a neural interface that analyzes an object's scent fingerprint to identify dangerous compounds at ports and inspection points, potentially replacing or supplementing x-ray and camera methods. The company aims to digitize the sense of scent through a neurotech device that interprets scents entering an olfactory system and prioritizes those relevant to customers, enabling the identification of hazardous compounds and the underlying object or its state. By translating olfactory information into actionable signals, Canaery seeks to enhance security and inspection efficiency in high-risk environments.

Twelve is a company that focuses on providing innovative cashless payment solutions tailored for various industries, including sports, events, catering, and museums. The company has developed a user-friendly online cash register and payment system designed primarily for sports clubs, which facilitates point-of-sale transactions and supports digital pricing along with debit and credit payments. Twelve aims to enhance the payment experience for clients by offering software modules, ordering solutions, and communication tools, thereby helping entrepreneurs and organizers achieve greater success in their initiatives.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Surf Bio is a preclinical biopharmaceutical company focused on developing innovative therapeutic solutions through its next-generation surfactant technology. This novel biotechnology platform aims to enhance drug effectiveness across various therapeutic areas, including diabetes, oncology, infectious diseases, and gene therapy. By utilizing this advanced technology, Surf Bio seeks to provide healthcare organizations worldwide with access to improved drugs that can better address the needs of patients suffering from critical diseases.

Phantom Neuro specializes in developing innovative muscle-machine interfaces that enhance robotic limb rehabilitation. The company focuses on creating solutions that improve mobility for users by integrating neurotechnology with robotic systems, aiming to facilitate precise control of robotic limbs and enable more natural movement.

Circuit Clinical is an integrated research organization that has emerged from the experience of a physician engaged in clinical research within a private practice. Established in 2015, the company aims to enhance the way clinical research is conducted by emphasizing physician and participant engagement. Circuit Clinical leverages a network of over 1 million patients, utilizing direct HIPAA/FDA-compliant Electronic Medical Record reviews to identify motivated participants. The organization provides research services that facilitate access to clinical research, guiding both experienced and novice community physicians and their patients through each step of the clinical research process. Through its technology products and focus on participant and physician experience, Circuit Clinical seeks to improve research site quality and patient safety, creating a more efficient pathway for clinical research.

Founded in 2013, ZymoChem develops eco-friendly chemical production processes using engineered microbes. These processes convert renewable feedstocks like sugars into industrial chemicals, minimizing carbon loss and enabling cost-competitive bio-based manufacturing.

Parthenon Therapeutics is inventing a novel class of anti-cancer therapies that reprogram the tumor microenvironment (TME). The interplay between cancer cells and their surrounding microenvironment is relevant in drug development as manycancers use the TME to build barriers that shield immune system attack. One approach, PRTH-101, breaks these barriers to overcome recalcitrant cancers. Based on research, the company is designing a portfolio of drug candidates to treat the right patients at the right time.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Circuit Clinical is an integrated research organization that has emerged from the experience of a physician engaged in clinical research within a private practice. Established in 2015, the company aims to enhance the way clinical research is conducted by emphasizing physician and participant engagement. Circuit Clinical leverages a network of over 1 million patients, utilizing direct HIPAA/FDA-compliant Electronic Medical Record reviews to identify motivated participants. The organization provides research services that facilitate access to clinical research, guiding both experienced and novice community physicians and their patients through each step of the clinical research process. Through its technology products and focus on participant and physician experience, Circuit Clinical seeks to improve research site quality and patient safety, creating a more efficient pathway for clinical research.

CytoVale is a medical technology company based in San Francisco that develops biomarkers derived from the mechanical properties of single cells. The company uses microfluidics to route and probe cells, enabling the measurement of multiple biophysical indicators at once. Its technology aims to advance early detection of immune-mediated diseases and sepsis through the analysis of cell mechanics and machine learning. By translating biophysical signals into diagnostic information, CytoVale seeks to improve diagnostic accuracy, support timely treatment decisions, and reduce healthcare costs.

Immusoft is a biotechnology company that develops autologous cell therapies using its Immune System Programming (ISP) technology. Founded in 2009 and headquartered in Seattle, Washington, the company reprograms patients' cells to produce gene-encoded medicines for treating various diseases.

Checkerspot, Inc. is a biotechnology company based in Berkeley, California, founded in 2016. It specializes in the development of sustainable performance materials derived from microalgae and biobased oils. The company focuses on innovating materials at a molecular level, utilizing its expertise in molecular foundry, chemistry, material science, and fabrication technology. Checkerspot aims to expand the range of molecular building blocks available for high-performance materials, particularly in industrial applications such as polyurethanes and textile finishes. Through its pioneering approach, Checkerspot contributes to the advancement of sustainable materials in various industries.

ShiraTronics develops neuromodulation therapies to treat chronic migraine by delivering continuous stimulation to targeted nerves to relieve, interrupt, and prevent migraine episodes. Founded in 2018 and based in Ireland, the company maintains an additional location in Minneapolis, Minnesota, and pursues innovative neuromodulation technology to address unmet neurological needs and improve patient outcomes.

CytoVale is a medical technology company based in San Francisco that develops biomarkers derived from the mechanical properties of single cells. The company uses microfluidics to route and probe cells, enabling the measurement of multiple biophysical indicators at once. Its technology aims to advance early detection of immune-mediated diseases and sepsis through the analysis of cell mechanics and machine learning. By translating biophysical signals into diagnostic information, CytoVale seeks to improve diagnostic accuracy, support timely treatment decisions, and reduce healthcare costs.

Curie Co is a life science company dedicated to developing sustainable alternatives to harmful chemicals by engineering enzymes and marine biomaterials. The company focuses on replacing petrochemical-based ingredients with biodegradable, biobased materials, branded as OceanSafe, derived from recycled marine sources. Curie Co aims to provide consumers with everyday products available at major retailers like Walmart, Target, and CVS, ensuring that these items remain affordable while minimizing environmental impact. By integrating advanced design methodologies, the company enables businesses to adopt eco-friendly packaging solutions without sacrificing quality or performance. Through its innovative approach, Curie Co aspires to become a trusted supplier and leader in the field of engineered enzymes and biopolymers.

Checkerspot, Inc. is a biotechnology company based in Berkeley, California, founded in 2016. It specializes in the development of sustainable performance materials derived from microalgae and biobased oils. The company focuses on innovating materials at a molecular level, utilizing its expertise in molecular foundry, chemistry, material science, and fabrication technology. Checkerspot aims to expand the range of molecular building blocks available for high-performance materials, particularly in industrial applications such as polyurethanes and textile finishes. Through its pioneering approach, Checkerspot contributes to the advancement of sustainable materials in various industries.

Phylagen is a data analytics company that leverages artificial intelligence to analyze the microbiome. It uses DNA sequencing and machine learning to derive insights from this vast, unseen world of microbes, benefiting customers across various industries.

Immusoft is a biotechnology company that develops autologous cell therapies using its Immune System Programming (ISP) technology. Founded in 2009 and headquartered in Seattle, Washington, the company reprograms patients' cells to produce gene-encoded medicines for treating various diseases.

CytoVale is a medical technology company based in San Francisco that develops biomarkers derived from the mechanical properties of single cells. The company uses microfluidics to route and probe cells, enabling the measurement of multiple biophysical indicators at once. Its technology aims to advance early detection of immune-mediated diseases and sepsis through the analysis of cell mechanics and machine learning. By translating biophysical signals into diagnostic information, CytoVale seeks to improve diagnostic accuracy, support timely treatment decisions, and reduce healthcare costs.

Quince Therapeutics is a preclinical-stage biopharmaceutical company focused on developing precision therapeutics for debilitating and rare diseases. Its core technology is a bone-targeting drug platform designed to deliver small molecules, peptides, or large molecules directly to the site of bone fractures and diseases, promoting rapid healing with fewer off-target safety concerns compared to non-targeted therapeutics.

Immusoft is a biotechnology company that develops autologous cell therapies using its Immune System Programming (ISP) technology. Founded in 2009 and headquartered in Seattle, Washington, the company reprograms patients' cells to produce gene-encoded medicines for treating various diseases.

3Scan develops robotic microscopy tools and software for large-scale tissue analysis and three-dimensional visualization. It builds devices that automate tissue sectioning and integrates automation with machine learning and computer vision to extract spatial data from tissue and generate detailed three-dimensional representations and quantitative analyses of complex anatomical structures. These capabilities enable higher-throughput histology and broader image analysis for researchers and clinicians, supporting advances in diagnostics and therapeutics for diseases such as cancer, neurodegenerative conditions, and cardiovascular disease.

Founded in 2011, Modern Meadow is a biofabrication company based in Brooklyn, New York. It specializes in growing animal-free leather using living cells, aiming to provide sustainable alternatives without compromising performance.