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Auron Therapeutics is to develop therapies to cure cancer by radically changing the paradigm of cancer therapeutics from cell killing, to transformation of malignant cells into normal cells. This transformation, called differentiation therapy, reactivates endogenous cellular programs to elicit tumor cell maturation and the transition from cancer to normal tissue. Its unique platforms allow for integration of large-omic datasets and miniaturized high throughput flow cytometry to rapidly identify and validate multiple targets and drugs in primary human patient samples.

Clasp Therapeutics is focused on advancing cancer treatment through its innovative immunotherapeutics platform. The company develops precision medicines designed to enhance the immune system's ability to identify and eliminate challenging tumors that possess common driver mutations, irrespective of the tumor type. By enabling the targeting of cancer-specific markers, Clasp Therapeutics aims to allow for precise and selective destruction of tumor cells, thereby improving therapeutic outcomes in the field of immuno-oncology.

Modifi Biosciences is a leader in direct DNA modification and the development of novel cancer therapeutics. The company's strategy for combating cancer centers around modifying tumor DNA in a way that renders cancer cells irreparable while preserving the integrity of healthy cells. This unique approach empowers researchers to disrupt traditional oncology drug development methods.

Thatch is a health benefits platform designed to assist businesses in managing employee healthcare effectively. It features an AI-driven service known as ThatchBot, which provides continuous support to employees for healthcare inquiries and expense management. The platform allows companies to create customized healthcare budgets that cater to individual employee needs. By offering a unified interface for healthcare spending and saving, Thatch enhances the delivery of personalized health and wellness benefits, enabling employees to navigate their healthcare options with greater ease and efficiency.

Thatch is a health benefits platform designed to assist businesses in managing employee healthcare effectively. It features an AI-driven service known as ThatchBot, which provides continuous support to employees for healthcare inquiries and expense management. The platform allows companies to create customized healthcare budgets that cater to individual employee needs. By offering a unified interface for healthcare spending and saving, Thatch enhances the delivery of personalized health and wellness benefits, enabling employees to navigate their healthcare options with greater ease and efficiency.

Paradigm is rebuilding the clinical research ecosystem by developing a platform that allows all patients equitable access to trials while improving trial efficiency and lowering barriers to participation for healthcare providers. It is an innovative company that is dedicated to transforming the clinical research ecosystem. Their mission is to create a more accessible and equitable healthcare system by developing a platform that enables patients from diverse backgrounds to participate in clinical trials. Clinical trials are essential for testing and developing new drugs, therapies, and medical devices, but historically, they have been plagued by inefficiencies, barriers to access, and inequities in patient representation. Paradigm aims to solve these challenges by creating a platform that uses technology and data-driven insights to streamline the clinical trial process, making it more efficient, cost-effective, and inclusive. The Paradigm platform is designed to facilitate seamless communication and collaboration among all stakeholders involved in clinical research, including patients, healthcare providers, pharmaceutical companies, and regulatory agencies. By leveraging technology such as AI, machine learning, and predictive analytics, Paradigm can identify and match eligible patients to clinical trials, streamline the recruitment and enrollment process, and provide real-time data insights to all stakeholders. Overall, Paradigm's innovative approach to clinical research has the potential to revolutionize the healthcare industry by improving patient outcomes, reducing healthcare costs, and accelerating the development of new treatments and therapies.

Alpheus Medical specializes in developing innovative treatment solutions for solid body cancers, focusing primarily on aggressive brain tumors. The company has created a novel sonodynamic therapy platform that employs a non-invasive drug-device combination for the outpatient treatment of recurrent glioblastoma multiforme (rGBM). This approach utilizes photodynamic therapy, which involves using light delivered through a minimally invasive device to target cancer cells that have been exposed to a photosensitizer. By offering these advanced therapeutic options, Alpheus Medical aims to provide effective alternatives to traditional invasive brain surgeries, enhancing patient care and treatment outcomes.

Vincere Health Inc. is a health technology company based in Allston, Massachusetts, founded in 2019 at the Harvard Innovation Labs. The company has developed a mobile application aimed at assisting users in quitting smoking and making healthier choices through a combination of behavioral nudges, incentives, and evidence-based interventions. Users can set personal health goals and test their adherence by using an attachable breathalyzer device to track their smoking habits daily. The platform offers immediate financial rewards for users who reduce their smoking and ultimately quit. Additionally, Vincere Health provides personalized coaching and real-time progress tracking to support chronic disease management and promote healthier lifestyle choices, addressing significant healthcare challenges primarily focused on smoking cessation.

Meliora Therapeutics is a biotech startup that is developing a machine learning-driven platform to identify the true mechanisms of action of oncology medications.

Naveris is a biotechnology company that provides highly sensitive blood tests for cancers to enable early diagnosis in the general asymptomatic population, real-time monitoring of response in patients undergoing treatment, and detection of cancer recurrence in patients in remission. The company's 3D biomimetic technology replicates the morphological, signaling, and cell lineage complexity of human tissues and tumors ex vivo. By empowering investigators to efficiently establish patient tumors ex vivo, its technology enables innovative designs for oncology clinical trials and precision medicine that seek to match the right therapies with the right patients. Naveris was founded in 2017 and is headquartered in Waltham, Massachusetts.

Auron Therapeutics is to develop therapies to cure cancer by radically changing the paradigm of cancer therapeutics from cell killing, to transformation of malignant cells into normal cells. This transformation, called differentiation therapy, reactivates endogenous cellular programs to elicit tumor cell maturation and the transition from cancer to normal tissue. Its unique platforms allow for integration of large-omic datasets and miniaturized high throughput flow cytometry to rapidly identify and validate multiple targets and drugs in primary human patient samples.

Persephone Biosciences develops healthcare technology designed to focus on microbial therapeutics for immuno-oncology applications. The company's technology uses artificial intelligence and omics techniques on multiple cancer patient gut microbiome and blood samples to identify microbes needed for normal immune function for population-scale patient data analytics, enabling lab researchers to design microbial drugs that prevent and fight cancer. Persephone Biosciences was founded in 2017 and is based in San Diego, California.

CellCentric’s primary programme targets a deubiquitinase (DUB) enzyme which is strongly associated with prostate cancer, a leading cause of mortality among men. The target modulates the androgen receptor pathway and can potentially combat the multiple resistance mechanisms seen with recently approved prostate cancer drugs such Xtandi and Zytiga. The programme also has potential clinical utility in non-small cell lung, breast and colon cancer.

Alpheus Medical specializes in developing innovative treatment solutions for solid body cancers, focusing primarily on aggressive brain tumors. The company has created a novel sonodynamic therapy platform that employs a non-invasive drug-device combination for the outpatient treatment of recurrent glioblastoma multiforme (rGBM). This approach utilizes photodynamic therapy, which involves using light delivered through a minimally invasive device to target cancer cells that have been exposed to a photosensitizer. By offering these advanced therapeutic options, Alpheus Medical aims to provide effective alternatives to traditional invasive brain surgeries, enhancing patient care and treatment outcomes.

TailorMed is a health IT company that works with providers, pharmacies and manufacturers to reduce patient financial toxicity and create efficiencies across the patient treatment lifecycle. Our end-to-end platform applies algorithms and automations to make the co-pay assistance and free drug order processes seamless and leverages our deep data set to create actionable insights.

Auron Therapeutics is to develop therapies to cure cancer by radically changing the paradigm of cancer therapeutics from cell killing, to transformation of malignant cells into normal cells. This transformation, called differentiation therapy, reactivates endogenous cellular programs to elicit tumor cell maturation and the transition from cancer to normal tissue. Its unique platforms allow for integration of large-omic datasets and miniaturized high throughput flow cytometry to rapidly identify and validate multiple targets and drugs in primary human patient samples.

Tmunity Therapeutics, Inc. is a biotherapeutics company based in Philadelphia, Pennsylvania, focused on developing innovative immunotherapies for cancer, infectious diseases, and autoimmune conditions. Founded in 2015, Tmunity specializes in creating engineered T cells, including T Cell Receptor (TCR) engineered T cells and regulatory T cells (Treg), utilizing proprietary technologies to activate, expand, and genetically modify T cells sourced from peripheral blood, cord blood, and tumors. The company aims to harness the potential of T cells to provide personalized next-generation treatments and is advancing its clinical programs in various disease areas. Tmunity's team is comprised of experts in T-cell biology, regulatory affairs, and clinical development, with a strong track record in executing successful cell and gene therapy trials. Additionally, Tmunity has established a robust manufacturing platform that supports multi-center clinical studies across diverse therapeutic indications.

Navigating Cancer owns and operates a Website for cancer patients and their supporters that allow them to read about the disease, discuss ailments with others, organize personal health records, and track medications and treatments. Navigating Cancer’s mission is to transform healthcare through patient-centered care by using technology to connect every cancer patient to their healthcare team, their own health records, and the right information at the right time. Navigating Cancer’s Patient Engagement Portal provides oncology clinics with a branded, online extension of their care model and helps them save time and money while providing better quality care. The company was founded in 2008 and is based in Seattle, Washington.

Castle Biosciences, Inc. is a commercial-stage biotechnology company focused on developing and commercializing diagnostic and prognostic tests for dermatological cancers. The company's lead product, DecisionDx-Melanoma, is a multi-gene expression profile test designed to identify stage I and II melanoma patients at high risk of metastasis by analyzing biological information from 31 genes in tumor tissue. In addition, Castle Biosciences offers the DecisionDx-UM test, which predicts metastasis risk in uveal melanoma patients, and is developing two late-stage products targeting cutaneous squamous cell carcinoma and suspicious pigmented lesions. The company's tests provide personalized, clinically actionable genomic information to assist physicians and patients in making informed treatment decisions. Founded in 2007 and headquartered in Friendswood, Texas, Castle Biosciences aims to significantly impact cancer diagnosis and management through its innovative diagnostic solutions.