Canaan Partners

Founded in 2014, Vivace Therapeutics is a biotechnology company based in the San Francisco Bay Area. It focuses on discovering and developing cancer therapeutics by targeting novel pathways, with a particular emphasis on the Hippo pathway which controls tissue regeneration and organ size.

Autobahn Therapeutics develops brain-targeting, small molecule therapies for central nervous system disorders. Its lead program ABX-002 is a thyroid hormone receptor beta agonist being developed as an adjunctive treatment for mood disorders, including major depressive disorder and bipolar depression. The company emphasizes precision tuning of CNS exposure, validated clinical and biologic targets, and biomarker-guided development across neuropsychiatry, neurodegeneration, and neuroinflammation to address high unmet medical needs and improve patient outcomes.

Truveris is a health information technology company based in New York that focuses on bringing transparency to the prescription drug ecosystem. Founded in 2009, Truveris develops management tools for sponsors and payers of claims under prescription benefit plans. Its platform offers data-driven insights to help customers, including patients, employers, retailers, pharmacy benefits stakeholders, and manufacturers, manage rising costs and market access challenges effectively. The company's solutions include RxChoice, TruBid, and RxDash, which serve various entities in the pharmacy value chain.

Founded in 2015 by Dr. Robert Schoelkopf, Quantum Circuits develops and manufactures quantum computers based on superconducting devices. The company focuses on creating full-stack quantum computers designed for efficient scaling, with a pioneering approach to error detection and correction.

Qlaris Bio is a clinical-stage biotechnology company based in Wellesley, Massachusetts, founded in 2017. The company specializes in developing innovative therapies for serious and debilitating ophthalmic diseases, with a focus on addressing episcleral venous pressure (EVP), a significant component of intraocular pressure (IOP). Qlaris Bio's lead therapy, QLS-101, aims to reduce IOP, thereby mitigating the risk of blindness in conditions such as Primary Open Angle Glaucoma and Normal Tension Glaucoma. The company also targets other high unmet need conditions related to disturbances in intraocular pressure, including a progressive pediatric rare disease with limited effective therapies.

Binarly is a global firmware and software supply chain security company founded in 2021 and based in Los Angeles. Its flagship Binarly Transparency Platform is an enterprise-class, AI-powered solution used by device manufacturers, original equipment manufacturers and product security teams to identify known and unknown vulnerabilities, misconfigurations and signs of malicious code implantation. The platform performs in-depth firmware introspection using proprietary machine learning and code analysis techniques to detect threats that originate below the operating system. Validated remediation playbooks help reduce the cost and time to respond to security exposures, supporting protection for businesses, critical infrastructure and consumers worldwide.

Lily AI is an innovative e-commerce product discovery platform based in Mountain View, California, that focuses on enhancing the sales performance of brands and retailers. The company specializes in integrating customer-centric product attributes into various facets of the e-commerce ecosystem, including site search engines and recommendation systems. By aligning brand messaging with customer intent, Lily AI improves on-site search, personalized product discovery, and demand prediction. This approach enables retailers, particularly in the fashion, home, and beauty sectors, to achieve significant increases in traffic, conversion rates, revenue, and brand loyalty.

JOOR operates a digital wholesale platform that connects fashion brands and retailers worldwide. The system replaces manual ordering with automated B2B order management, payment processing, and virtual showrooms, enabling faster transactions and reduced errors. It supplies data analytics to help users track performance, cut costs, and enhance customer experience. Through a curated network of global partners, the platform supports brands and buyers in building strategic relationships and scaling operations across markets.

Diligent Robotics Inc. is a company that specializes in the development and manufacturing of hospital service robots. Founded in 2017 and headquartered in Austin, Texas, the company has created Moxi, a robotic assistant designed to support clinical and nursing staff with logistical tasks in hospital settings. Moxi is equipped with advanced mobile manipulation, social intelligence, and human-guided learning capabilities, allowing it to collaborate effectively with human teams. By automating routine logistical duties, Moxi enables healthcare providers to focus more on direct patient care, thereby enhancing patient satisfaction, service quality, and safety in healthcare environments. The company also develops artificial intelligence-based software suites that allow its robots to adapt to and thrive in dynamic, semi-structured environments.

Founded in 2021, Atmosfy is a San Francisco-based platform that helps users discover dining and nightlife options through video reviews. It covers restaurants, bars, cafes, and clubs nearby or afar, assisting users in making informed decisions based on their preferences.

Tomorrow.io develops a SaaS weather intelligence platform that provides real-time, location-specific weather forecasts tailored to industries affected by weather. The platform helps organizations predict business impacts of weather, streamline communication, and optimize operations to improve efficiency and margins. It combines traditional meteorology data with signals from wireless networks, connected vehicles, satellites, street cameras, and other sources to deliver micro-forecast information. It serves clients across sectors worldwide, enabling countries, businesses, and individuals to manage weather-related challenges and improve decision-making. The company operates in North America, Latin America, Europe, and Asia.

OncoResponse is an immuno‑oncology biotechnology company that uses a proprietary human antibody platform to discover novel targets and develop fully human monoclonal antibodies for cancer treatment. By interrogating the adaptive immune system of patients who respond exceptionally well to checkpoint inhibition, the company identifies genuine human antibodies against high‑value targets linked with immunosuppressive myeloid biology. Its pipeline aims to alleviate tumor‑microenvironment immunosuppression and enhance immune activation, converting cold tumors into hot ones and providing new therapeutic options for patients.

Antiva Biosciences, Inc. is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral therapies for human papillomavirus (HPV) infections. Established in 2012, the company aims to prevent cancer by treating precancerous lesions associated with HPV. Antiva's innovative approach includes localized therapeutics and small molecule antivirals that target HPV and other viral infections. The company is currently conducting clinical trials for high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias. Through its medicinal chemistry platform, Antiva strives to enhance health outcomes for patients affected by HPV-related diseases and other viral infections.

Kepler Communications designs, develops, and operates satellite networks for global connectivity. It specializes in Low-Earth Orbit (LEO) satellites, PolarConnect for extreme environments, Global Data Service for large data transfers, and everywhereIOT for IoT devices. Serving industries such as maritime, natural resources, research, defense, and logistics.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

Komprise is a multi-cloud data management platform that enables organizations to analyze, move, and access file and object data across on-premises and cloud storage. It uses data growth analytics to identify hot and cold data and manages the data lifecycle across multiple storage vendors, including replication, archiving, and migration. The platform can relocate unstructured data to secondary storage based on criteria such as age, usage, or security to ensure data resides in the appropriate location at the right time. Founded in 2014 and headquartered in Campbell, California, Komprise focuses on intelligent data management to improve data accessibility and storage efficiency.

Normunity is a biotechnology company that develops precision immuno‑oncology medicines, termed immune normalizers, designed to restore the body’s natural immune response against cancer. Leveraging a partnership with Dr. Lieping Chen’s laboratory at Yale School of Medicine, the company focuses on newly discovered mechanisms of immune disruption, such as the exclusion of T‑cells from immune‑sensitive tumors and other barriers to normal immune function. Its pipeline includes programs targeting these mechanisms to enable clinicians to treat cancer by reactivating the patient’s own immunity. Normunity operates from offices in Boston, Massachusetts, and West Haven, Connecticut.

Alkymi develops an AI-powered platform that automates the processing of unstructured investment data. Its solution transforms financial documents like capital calls and brokerage statements into standardized datasets, enabling financial services professionals to accelerate deal reviews, serve more clients, and respond swiftly to market changes.

EMTECH is a fintech company that modernizes central banking infrastructure. It offers an API-First Platform connecting central banks with fintechs for embedded regulatory compliance and central bank digital currency, enabling financial inclusion and market resilience.

Lily AI is an innovative e-commerce product discovery platform based in Mountain View, California, that focuses on enhancing the sales performance of brands and retailers. The company specializes in integrating customer-centric product attributes into various facets of the e-commerce ecosystem, including site search engines and recommendation systems. By aligning brand messaging with customer intent, Lily AI improves on-site search, personalized product discovery, and demand prediction. This approach enables retailers, particularly in the fashion, home, and beauty sectors, to achieve significant increases in traffic, conversion rates, revenue, and brand loyalty.

Dusty Robotics, Inc. is a technology company that specializes in automated layout services for the construction industry. Founded in 2018 and headquartered in Mountain View, California, the company has developed the FieldPrinter, a robotic tool that translates digital building information modeling (BIM) designs into accurate, on-site layouts. By integrating BIM information directly onto construction-site floors, Dusty Robotics eliminates manual processes, thereby enhancing efficiency in the construction workflow. The company's innovative solutions serve a diverse clientele, including owners, general contractors, subcontractors, and builders, helping them to reduce labor and material waste and improve the overall design-build-operate lifecycle.

Founded in 2019, Lev specializes in digitizing commercial real estate transactions via its technology platform. It offers financial services, including lending solutions and capital management.

BoostUp.ai offers a sales intelligence platform that transforms unstructured data into actionable insights. Its solution analyzes risks at macro and micro levels, enhancing forecasting accuracy, efficiency, and predictability across the entire sales process. The company serves prominent clients such as Teradata, Degreed, and Iterable.

Hermeus Corporation, founded in 2018 and based in Atlanta, Georgia, is focused on developing hypersonic aircraft capable of flying at speeds exceeding Mach 5. These advanced jets significantly reduce travel times, allowing a flight from New York to London to take just 90 minutes instead of the typical seven hours. Hermeus aims to enhance the global transportation network by enabling businesses to operate efficiently without major changes to existing aviation infrastructure. The company's innovations not only decrease flight durations but also enhance safety for long-haul and business class air travel, facilitating improved connectivity between major global cities.

EMTECH is a fintech company that modernizes central banking infrastructure. It offers an API-First Platform connecting central banks with fintechs for embedded regulatory compliance and central bank digital currency, enabling financial inclusion and market resilience.

Rondo Therapeutics is a biopharmaceutical company based in Hayward, California, specializing in the discovery and development of innovative bispecific antibodies aimed at activating the immune system to combat cancer. Founded in 2021, the company focuses on creating cancer immunotherapies specifically for solid tumor types that do not respond to existing immune checkpoint inhibitors. By addressing areas of unmet medical need, Rondo Therapeutics aims to advance novel therapeutic options for patients facing challenging cancer diagnoses.

Instrumental, Inc. specializes in developing software solutions that enhance the efficiency of assembly lines, enabling them to operate autonomously while adapting to various parts and processes. Founded by former Apple engineers Anna-Katrina Shedletsky and Samuel Weiss, the company aims to reduce costs associated with scrap and rework by allowing manufacturers to identify and resolve issues on their assembly lines. Instrumental's technology has been deployed in multiple global assembly lines at leading manufacturers, helping to prevent delays in development schedules and start production at higher yields. In addition to its software offerings, Instrumental also provides services related to high-performance computing, data storage, and business continuity, catering to both commercial and government sectors. The firm is headquartered in Saint Paul, Minnesota, and has been operational since 1991.

Gemist is a Los Angeles-based jewelry company established in 2018. It specializes in designing and manufacturing customizable rings and other accessories, with a focus on millennial consumers. Gemist's unique business model allows customers to design their pieces online, receive free replicas for trial at home before purchasing.

Founded in 2018, Azibo is a financial services platform dedicated to streamlining rental property management. It offers solutions for rent collection, banking, lending, and insurance, aiming to improve efficiency and reduce administrative burden for small real estate owners.

Apex.AI develops software for autonomous mobility, offering a framework and tools that simplify the development of safe and secure autonomous driving applications. Its platform includes Apex.OS, which abstracts hardware, middleware, kernels, interfaces, and drivers into usable APIs, and Apex.Autonomy for safety-critical applications. It also offers MARV.Automotive, a data management platform that transfers vehicle data to the cloud, enables dynamic search-based analytics, analyzes partial logs, runs algorithms on real data, and provides graphical data introspection and team collaboration. Founded in 2017 and based in Palo Alto, California, Apex.AI builds on open-source software such as ROS and Eclipse iceoryx to provide building blocks for developers creating AI and safety-critical software for autonomous vehicles.

Founded in 2016, Sounding Board Labs develops a platform that provides personalized coaching for leaders and new managers. Its platform offers executive coaching, connects through phone, video, and chat, creates development plans, and provides surveys and reporting to track progress.

nTopology, Inc. is an engineering software company founded in 2013 and headquartered in New York, New York. The company specializes in developing design software and tools aimed at optimizing manufacturing processes. Its flagship platform, nTopology, empowers engineers to create lightweight and optimized parts that meet specific functional requirements. The software includes features such as Lightweighting, Architected Materials, Topology Optimization, Additive Manufacturing, and Design Analysis, facilitating the integration of geometry and simulation data into manufacturing-ready models. By streamlining workflows and enhancing team collaboration, nTopology serves a diverse range of industries, including aerospace and defense, medical, automotive, consumer products, and education.

CompStak, Inc., founded in 2011 and headquartered in New York, operates an online platform that provides a comprehensive database of commercial lease comparables. Utilizing a crowd-sourced model, CompStak facilitates the exchange of detailed lease information, which includes tenant names, addresses, rental rates, square footage, landlord concessions, broker identities, and other pertinent data. This information is critical for real estate investors, brokers, asset managers, and appraisers as they conduct valuations and analyses of commercial properties. CompStak's platform serves various stakeholders in the real estate market, enabling informed decision-making in significant investments and property comparisons. Additionally, CompStak has established a strategic partnership with Knowledge Cubed to enhance its data offerings, further solidifying its position in the industry.

Papa, Inc. operates an online platform designed to connect college students with senior citizens, facilitating various services to assist older adults in maintaining their independence and well-being. Founded in 2016 and based in Miami, Florida, the platform enables college and nursing students to provide companionship and assistance in areas such as transportation, house chores, technology lessons, grocery shopping, and caregiving. By connecting vetted companions with older adults, Papa aims to enhance social connections and support for seniors, allowing them to live securely and happily at home.

Antiva Biosciences, Inc. is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral therapies for human papillomavirus (HPV) infections. Established in 2012, the company aims to prevent cancer by treating precancerous lesions associated with HPV. Antiva's innovative approach includes localized therapeutics and small molecule antivirals that target HPV and other viral infections. The company is currently conducting clinical trials for high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias. Through its medicinal chemistry platform, Antiva strives to enhance health outcomes for patients affected by HPV-related diseases and other viral infections.

Bzaar is an online B2B cross-border marketplace founded in 2020 and headquartered in San Francisco, California. The company specializes in connecting small businesses with a diverse range of products, including home improvements, fashion, cookware, and bakeware, primarily sourced from South and South-East Asia. Bzaar provides retailers access to niche and artisanal products from value-based brands that are often unavailable at traditional big-box retail chains. By facilitating cross-border wholesale transactions, Bzaar enhances buying transparency and predictability for small and medium enterprises, allowing them to effectively meet their inventory needs.

TrueFort specializes in real-time application and cloud workload protection. Founded in 2015, the company offers solutions such as application-first security, out-of-box analytics for applications, and bring-your-own-agent capabilities. Its flagship product, Fortress, employs advanced behavioral analysis and automation to enhance security across diverse environments.

MindTickle offers a sales readiness platform that enables companies to train, coach, and align their customer-facing teams. Its data-driven approach combines on-demand training, mobile updates, gamification, coaching, role-play, and assessment tools to enhance sales performance. Headquartered in San Francisco and Pune, MindTickle is privately held.

Offlimits, Inc. is a New York-based company that specializes in producing and selling innovative breakfast products, primarily focusing on cereal. Incorporated in 2019, Offlimits offers a variety of vegan, organic, and gluten-free cereals, featuring unique flavors such as Zombie Vanilla & Pandan and Dash Coffee & Cocoa, along with functional ingredients like adaptogens and ashwagandha. The company also engages in direct online sales, allowing consumers to access its diverse range of plant-based cereal options. By combining creativity with health-conscious ingredients, Offlimits aims to redefine the breakfast experience.

Berkshire Grey, Inc. is a technology company specializing in the development of artificial intelligence-driven robotic and automated material handling systems. Founded in 2013 and based in Lexington, Massachusetts, the company focuses on automating tasks traditionally performed by humans in commercial settings, enhancing efficiency in fulfillment, supply chain, and logistics operations. Its offerings include a range of robotic solutions, such as autonomous picking and sorting systems, mobile robotic units, and dynamic parcel sortation technologies. Additionally, Berkshire Grey provides electromechanical solutions that incorporate vision systems and advanced scanning technologies. By leveraging AI, computer vision, and machine learning, the company's systems enable clients to achieve higher accuracy and throughput speeds while managing diverse product assortments. The majority of its revenue is generated from North America, positioning Berkshire Grey as a significant player in the automation landscape.

Nate Inc. is a New York-based company founded in 2018 that specializes in developing artificial intelligence software designed to facilitate online transactions on behalf of users. The company offers a shopping app that allows individuals to purchase products from various online retailers with ease, requiring only a single click. In addition to its primary function as a shopping solution, the app includes a social component, enabling users to share information about their purchases with friends. This integration of shopping and social interaction positions Nate as a versatile platform in the e-commerce space.

JOOR operates a digital wholesale platform that connects fashion brands and retailers worldwide. The system replaces manual ordering with automated B2B order management, payment processing, and virtual showrooms, enabling faster transactions and reduced errors. It supplies data analytics to help users track performance, cut costs, and enhance customer experience. Through a curated network of global partners, the platform supports brands and buyers in building strategic relationships and scaling operations across markets.

Dusty Robotics, Inc. is a technology company that specializes in automated layout services for the construction industry. Founded in 2018 and headquartered in Mountain View, California, the company has developed the FieldPrinter, a robotic tool that translates digital building information modeling (BIM) designs into accurate, on-site layouts. By integrating BIM information directly onto construction-site floors, Dusty Robotics eliminates manual processes, thereby enhancing efficiency in the construction workflow. The company's innovative solutions serve a diverse clientele, including owners, general contractors, subcontractors, and builders, helping them to reduce labor and material waste and improve the overall design-build-operate lifecycle.

Embroker, Inc. is a digital insurance brokerage that specializes in providing insurance services to small and mid-sized businesses. Founded in 2015 and headquartered in San Francisco, with additional offices in Chicago, Boston, Denver, and New York, Embroker utilizes an online platform to streamline the process of purchasing, managing, and analyzing commercial insurance policies. The platform allows clients to automate the sharing, requesting, and tracking of proof of coverage, as well as monitor claims in real-time. Embroker offers a wide range of insurance products, including Commercial General Liability, property insurance, professional liability, and employee benefits, among others. The company also provides tools for peer comparison, enabling clients to benchmark their policies against industry standards. By combining technology with broker expertise, Embroker aims to enhance the efficiency and effectiveness of the $800 billion property and casualty insurance market, helping businesses save time and secure optimal coverage.

Kepler Communications designs, develops, and operates satellite networks for global connectivity. It specializes in Low-Earth Orbit (LEO) satellites, PolarConnect for extreme environments, Global Data Service for large data transfers, and everywhereIOT for IoT devices. Serving industries such as maritime, natural resources, research, defense, and logistics.

PreShow is a company founded in 2019 and based in New York that aims to revolutionize the moviegoing experience by making it free for consumers. The company has developed a proprietary app that connects brands with moviegoers on a one-to-one basis, allowing users to earn the opportunity to watch movies in theaters without charge. By leveraging this attention exchange model, PreShow enables brands to engage directly with their target audience while providing users with a way to enjoy cinema at no cost.

BoostUp.ai offers a sales intelligence platform that transforms unstructured data into actionable insights. Its solution analyzes risks at macro and micro levels, enhancing forecasting accuracy, efficiency, and predictability across the entire sales process. The company serves prominent clients such as Teradata, Degreed, and Iterable.

OncoResponse is an immuno‑oncology biotechnology company that uses a proprietary human antibody platform to discover novel targets and develop fully human monoclonal antibodies for cancer treatment. By interrogating the adaptive immune system of patients who respond exceptionally well to checkpoint inhibition, the company identifies genuine human antibodies against high‑value targets linked with immunosuppressive myeloid biology. Its pipeline aims to alleviate tumor‑microenvironment immunosuppression and enhance immune activation, converting cold tumors into hot ones and providing new therapeutic options for patients.

Tyra Biosciences is a biotechnology company focused on developing precision therapies for cancer. It uses its proprietary SNAP platform to create next-generation drug candidates that target acquired drug resistance, with an initial focus on the Fibroblast Growth Factor Receptor (FGFR) family.

Founded in 2019, Lev specializes in digitizing commercial real estate transactions via its technology platform. It offers financial services, including lending solutions and capital management.

Axis Security Inc. is a cybersecurity company founded in 2018 and based in Palo Alto, California. It specializes in Zero Trust Network Access solutions, providing a cloud security platform that ensures secure remote access to applications. The company's technology focuses on application isolation and employs a context-aware approach to security, evaluating multiple factors to ensure that only authorized users can access specific resources within a network. This business-centric strategy allows organizations to maintain control over sensitive information and manage access for employees, partners, and other stakeholders effectively.

PerimeterX, Inc. is a cybersecurity company that specializes in developing solutions to prevent automated attacks and malicious web behavior. Founded in 2014 and headquartered in San Mateo, California, with additional locations in London, Miami, and a subsidiary in Tel Aviv, the company offers a suite of products aimed at protecting web infrastructure. Its flagship solutions, known as PerimeterX Bot Defender, provide real-time defenses against various types of bot attacks, including those targeting websites, mobile applications, and APIs. By leveraging behavioral analytics and advanced threat detection techniques, PerimeterX helps organizations in sectors such as e-commerce, travel, and media safeguard their digital assets from account abuse, web scraping, and marketing fraud. The company's innovative approach has garnered recognition, including being listed among the top cybersecurity startups and promising artificial intelligence firms.

Founded in 2016, Sounding Board Labs develops a platform that provides personalized coaching for leaders and new managers. Its platform offers executive coaching, connects through phone, video, and chat, creates development plans, and provides surveys and reporting to track progress.

Apartment List is an online rental marketplace in the United States that connects renters with landlords. The platform offers a search experience with details on prices, locations, and amenities through web and mobile interfaces. The company emphasizes a fair, transparent, and simple renting process and provides a personalized search that learns user preferences to streamline finding suitable apartments. Based in San Francisco, it serves tenants and property owners by helping users discover listings and make informed decisions, reducing time and hassle in the search. Established in the late 2000s, Apartment List aims to make the home-finding process more personal, flexible, and efficient.

Founded in 2014, Vivace Therapeutics is a biotechnology company based in the San Francisco Bay Area. It focuses on discovering and developing cancer therapeutics by targeting novel pathways, with a particular emphasis on the Hippo pathway which controls tissue regeneration and organ size.

Mate Fertility is a technology-driven fertility clinic founded in 2020 and based in Los Angeles, California. The company aims to make parenthood more accessible by providing comprehensive fertility services at affordable prices. It operates a platform that connects patients to fertility clinics and offers telemedicine options for various treatments and therapies. By delivering end-to-end fertility services, Mate Fertility ensures that patients receive expert guidance and care throughout their fertility journey, making the process more comfortable and manageable.

MindTickle offers a sales readiness platform that enables companies to train, coach, and align their customer-facing teams. Its data-driven approach combines on-demand training, mobile updates, gamification, coaching, role-play, and assessment tools to enhance sales performance. Headquartered in San Francisco and Pune, MindTickle is privately held.

Bumped, Inc. is a technology company based in Portland, Oregon, that offers a unique platform enabling publicly traded consumer brands to reward their customers with fractional shares of stock as loyalty rewards. Founded in 2017, Bumped aims to create one-to-one relationships between brands and their customers by allowing consumers to receive stock or exchange-traded funds in return for their purchases. This innovative approach transforms loyal shoppers into shareholders, granting everyday individuals access to the stock market while simultaneously enhancing brand loyalty. Through its application, Bumped tracks customer spending with participating brands and facilitates the distribution of stock rewards, thereby aligning the interests of businesses and their customers.

Hermeus Corporation, founded in 2018 and based in Atlanta, Georgia, is focused on developing hypersonic aircraft capable of flying at speeds exceeding Mach 5. These advanced jets significantly reduce travel times, allowing a flight from New York to London to take just 90 minutes instead of the typical seven hours. Hermeus aims to enhance the global transportation network by enabling businesses to operate efficiently without major changes to existing aviation infrastructure. The company's innovations not only decrease flight durations but also enhance safety for long-haul and business class air travel, facilitating improved connectivity between major global cities.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

Vineti, Inc. is a technology company focused on advancing the development and delivery of personalized therapies, particularly in the realm of cell and gene treatments for serious conditions like cancer. Founded in 2016 and headquartered in San Francisco, California, Vineti offers a cloud-based platform known as the Personalized Therapy Management (PTM) platform. This platform integrates various aspects of the therapeutic supply chain, including operations, manufacturing, quality assurance, and regulatory compliance, to streamline and automate processes. It addresses critical challenges faced by patients, healthcare providers, pharmaceutical companies, and regulatory bodies in the commercialization of personalized medicine. By enhancing supply chain orchestration and ensuring compliance with regulatory standards, Vineti aims to expand patient access to innovative therapies. The company also maintains regional offices in Bethesda, Maryland, and Yerevan, Armenia.

Founded in 2018, Genemod specializes in developing inventory management software tailored for life scientists. Its platform integrates scientific tools with project management features, aiming to enhance collaboration and streamline daily operations within research labs.

Axis Security Inc. is a cybersecurity company founded in 2018 and based in Palo Alto, California. It specializes in Zero Trust Network Access solutions, providing a cloud security platform that ensures secure remote access to applications. The company's technology focuses on application isolation and employs a context-aware approach to security, evaluating multiple factors to ensure that only authorized users can access specific resources within a network. This business-centric strategy allows organizations to maintain control over sensitive information and manage access for employees, partners, and other stakeholders effectively.

Papa, Inc. operates an online platform designed to connect college students with senior citizens, facilitating various services to assist older adults in maintaining their independence and well-being. Founded in 2016 and based in Miami, Florida, the platform enables college and nursing students to provide companionship and assistance in areas such as transportation, house chores, technology lessons, grocery shopping, and caregiving. By connecting vetted companions with older adults, Papa aims to enhance social connections and support for seniors, allowing them to live securely and happily at home.

Synthekine Inc. is a biotechnology company based in Menlo Park, California, specializing in the development of engineered cytokine therapies and immunotherapies aimed at treating cancer and autoimmune disorders. Founded in 2018, Synthekine utilizes advanced platform technologies, including engineered partial agonists and orthogonal cell therapies, to enhance the efficacy of cytokines while minimizing their toxic side effects. The company's innovative Synthekine Platform employs surrogate agonists instead of traditional mutant cytokines to create selective immunotherapies. Its product pipeline features candidates such as STK-009, an orthogonal ligand paired with SYNCAR-001, an orthogonal receptor-modified CAR-T therapy targeting CD-19. Additionally, Synthekine is developing STK-012, partial agonists of IL-2, and other novel immunotherapies that integrate cytokine receptors to initiate new signaling pathways without relying on wild-type cytokines.

ManiMe, Inc. is a company based in Santa Monica, California, that develops, manufactures, and sells ready-to-wear manicures. Founded in 2017, it specializes in stick-on gels created using advanced 3D printing technology. The company's products are available for purchase online, providing a convenient solution for busy women who wish to maintain their nail care without the need for traditional salon visits. Additionally, ManiMe offers a platform for nail artists, fostering their growth and aligning with their professional aspirations.

nTopology, Inc. is an engineering software company founded in 2013 and headquartered in New York, New York. The company specializes in developing design software and tools aimed at optimizing manufacturing processes. Its flagship platform, nTopology, empowers engineers to create lightweight and optimized parts that meet specific functional requirements. The software includes features such as Lightweighting, Architected Materials, Topology Optimization, Additive Manufacturing, and Design Analysis, facilitating the integration of geometry and simulation data into manufacturing-ready models. By streamlining workflows and enhancing team collaboration, nTopology serves a diverse range of industries, including aerospace and defense, medical, automotive, consumer products, and education.

BoostUp.ai offers a sales intelligence platform that transforms unstructured data into actionable insights. Its solution analyzes risks at macro and micro levels, enhancing forecasting accuracy, efficiency, and predictability across the entire sales process. The company serves prominent clients such as Teradata, Degreed, and Iterable.

Zibo Inc. is a financial services company that specializes in providing a banking and payments platform tailored for independent landlords. Established in 2018 and based in Redwood City, California, Zibo offers a range of services designed to streamline the management of rental properties. Its platform facilitates rent payments, automates rent collection, and assists with financial management tasks such as tax preparation and accounting. Additionally, Zibo provides tools for tenant screening and rental applications, along with insurance services for residential rental properties. By offering a comprehensive suite of services at no cost, Zibo aims to help landlords enhance cash flow and effectively manage their rental portfolios.

Instrumental, Inc. specializes in developing software solutions that enhance the efficiency of assembly lines, enabling them to operate autonomously while adapting to various parts and processes. Founded by former Apple engineers Anna-Katrina Shedletsky and Samuel Weiss, the company aims to reduce costs associated with scrap and rework by allowing manufacturers to identify and resolve issues on their assembly lines. Instrumental's technology has been deployed in multiple global assembly lines at leading manufacturers, helping to prevent delays in development schedules and start production at higher yields. In addition to its software offerings, Instrumental also provides services related to high-performance computing, data storage, and business continuity, catering to both commercial and government sectors. The firm is headquartered in Saint Paul, Minnesota, and has been operational since 1991.

Nguyen Coffee Supply, LLC is a specialty Vietnamese coffee company based in Brooklyn, New York, founded in 2018 by entrepreneur-activist Sahra Nguyen. The company focuses on sourcing, importing, and roasting Vietnamese coffees, offering a range of products including arabica coffee, peaberry coffee beans, and filtered coffee. Nguyen Coffee Supply aims to enhance economic opportunities for Vietnamese farmers while promoting a diverse and inclusive coffee culture. The company champions the potential of Vietnamese robusta coffee, emphasizing sustainability and cultural integrity in its operations. Through its online platform, Nguyen Coffee Supply provides customers with access to freshly roasted Vietnamese coffees, catering to various brewing preferences.

Juno Residential, Inc. is a company focused on the development of residential apartments, incorporating innovative construction methods to provide environmentally friendly housing solutions. Based in San Francisco, California, Juno specializes in prefabricated houses, utilizing techniques that emphasize speed and efficiency. The company is committed to sustainability, employing organic and low-carbon materials, such as mass timber, in its projects. By offering modern and curated living spaces, Juno aims to address the growing demand for sustainable housing alternatives in urban environments. Founded in 2018, Juno Residential, Inc. was previously known as Lighthouse Residential, Inc.

Hallo, Co. is a San Francisco-based company that specializes in creating an online hiring events platform aimed at fostering connections between students, universities, and employers. Founded in 2017, Hallo offers a range of digital services, including career fairs, tech talks, and all-hands meetings, to facilitate effective recruitment and networking opportunities. Additionally, Hallo positions itself as the first AI-driven career platform, providing job seekers with on-demand coaching, interview training, and access to actionable networks. Through its innovative approach, Hallo seeks to enhance the job search experience and improve outcomes for both candidates and companies.

Nate Inc. is a New York-based company founded in 2018 that specializes in developing artificial intelligence software designed to facilitate online transactions on behalf of users. The company offers a shopping app that allows individuals to purchase products from various online retailers with ease, requiring only a single click. In addition to its primary function as a shopping solution, the app includes a social component, enabling users to share information about their purchases with friends. This integration of shopping and social interaction positions Nate as a versatile platform in the e-commerce space.

Alkymi develops an AI-powered platform that automates the processing of unstructured investment data. Its solution transforms financial documents like capital calls and brokerage statements into standardized datasets, enabling financial services professionals to accelerate deal reviews, serve more clients, and respond swiftly to market changes.

Founded in 2016, READY Robotics is headquartered in Columbus, Ohio. The company specializes in developing ForgeOS, an industrial operating system for robotics and automation. This patented technology enables manufacturers to deploy and manage robots efficiently using a standardized set of low-code apps, particularly beneficial for high-mix/low-volume manufacturing.

Ladder is a digital life insurance company founded in 2015. It offers flexible term coverage up to $8M across all U.S. states, with an all-digital application process and real-time underwriting, aiming to make life insurance more accessible and affordable.

Leanplum Inc. is a mobile marketing platform that specializes in enhancing engagement for brands through a unified, multichannel approach. Founded in 2012 and headquartered in San Francisco, with additional offices in New York, London, Bulgaria, and Amsterdam, Leanplum enables businesses to optimize their mobile applications and marketing efforts. The platform offers a range of services including messaging, automation, app editing, personalization, A/B testing, and analytics, allowing product teams to conduct real-time optimization tests and analyze results effectively. Renowned global brands such as Tinder, Grab, Tesco, and Zynga utilize Leanplum to orchestrate integrated campaigns that foster customer loyalty and drive growth. By transforming data into actionable insights, Leanplum helps companies understand user needs, delivering relevant experiences that enhance brand engagement and establish long-term customer relationships.

Founded in New York in 2018, Bravo Sierra is a performance wellness company that pioneers user-driven personal care and nutrition products. It collaborates directly with U.S. military active duty service members to deliver responsive and accurate products for both military personnel and civilians.

Vineti, Inc. is a technology company focused on advancing the development and delivery of personalized therapies, particularly in the realm of cell and gene treatments for serious conditions like cancer. Founded in 2016 and headquartered in San Francisco, California, Vineti offers a cloud-based platform known as the Personalized Therapy Management (PTM) platform. This platform integrates various aspects of the therapeutic supply chain, including operations, manufacturing, quality assurance, and regulatory compliance, to streamline and automate processes. It addresses critical challenges faced by patients, healthcare providers, pharmaceutical companies, and regulatory bodies in the commercialization of personalized medicine. By enhancing supply chain orchestration and ensuring compliance with regulatory standards, Vineti aims to expand patient access to innovative therapies. The company also maintains regional offices in Bethesda, Maryland, and Yerevan, Armenia.

Berkshire Grey, Inc. is a technology company specializing in the development of artificial intelligence-driven robotic and automated material handling systems. Founded in 2013 and based in Lexington, Massachusetts, the company focuses on automating tasks traditionally performed by humans in commercial settings, enhancing efficiency in fulfillment, supply chain, and logistics operations. Its offerings include a range of robotic solutions, such as autonomous picking and sorting systems, mobile robotic units, and dynamic parcel sortation technologies. Additionally, Berkshire Grey provides electromechanical solutions that incorporate vision systems and advanced scanning technologies. By leveraging AI, computer vision, and machine learning, the company's systems enable clients to achieve higher accuracy and throughput speeds while managing diverse product assortments. The majority of its revenue is generated from North America, positioning Berkshire Grey as a significant player in the automation landscape.

Tyra Biosciences is a biotechnology company focused on developing precision therapies for cancer. It uses its proprietary SNAP platform to create next-generation drug candidates that target acquired drug resistance, with an initial focus on the Fibroblast Growth Factor Receptor (FGFR) family.

Lily AI is an innovative e-commerce product discovery platform based in Mountain View, California, that focuses on enhancing the sales performance of brands and retailers. The company specializes in integrating customer-centric product attributes into various facets of the e-commerce ecosystem, including site search engines and recommendation systems. By aligning brand messaging with customer intent, Lily AI improves on-site search, personalized product discovery, and demand prediction. This approach enables retailers, particularly in the fashion, home, and beauty sectors, to achieve significant increases in traffic, conversion rates, revenue, and brand loyalty.

Capella Space is an information services company based in San Francisco that operates a constellation of small satellites equipped with synthetic aperture radar, delivering on-demand, high-resolution radar imagery of the Earth's surface. The SAR imagery can be acquired through clouds, smoke, fog, and darkness, enabling continuous global monitoring and rapid insight across industries. Capella's services support infrastructure monitoring, agriculture, disaster response, maritime domain awareness, city planning and mapping, and business intelligence, helping customers detect sub-meter surface changes, track economic activity, and monitor environmental and security-related conditions. Founded in 2016, Capella Space provides timely earth observation for commerce, conservation, and safety.

Apex.AI develops software for autonomous mobility, offering a framework and tools that simplify the development of safe and secure autonomous driving applications. Its platform includes Apex.OS, which abstracts hardware, middleware, kernels, interfaces, and drivers into usable APIs, and Apex.Autonomy for safety-critical applications. It also offers MARV.Automotive, a data management platform that transfers vehicle data to the cloud, enables dynamic search-based analytics, analyzes partial logs, runs algorithms on real data, and provides graphical data introspection and team collaboration. Founded in 2017 and based in Palo Alto, California, Apex.AI builds on open-source software such as ROS and Eclipse iceoryx to provide building blocks for developers creating AI and safety-critical software for autonomous vehicles.

Intrepida Bio, Inc. is a biotechnology company focused on developing innovative cancer therapies that enhance the body’s innate immune response. Founded in 2016 and headquartered in San Diego, California, the company specializes in creating medicines that modulate the innate immune system to combat cancer and other diseases. Intrepida Bio is particularly engaged in the development of monoclonal antibodies aimed at novel targets such as BAG3 and its receptor IFITM-2, which are involved in establishing a tumor-friendly environment. Through its research efforts, Intrepida Bio aims to provide patients with effective treatment options to fight cancer.

Papa, Inc. operates an online platform designed to connect college students with senior citizens, facilitating various services to assist older adults in maintaining their independence and well-being. Founded in 2016 and based in Miami, Florida, the platform enables college and nursing students to provide companionship and assistance in areas such as transportation, house chores, technology lessons, grocery shopping, and caregiving. By connecting vetted companions with older adults, Papa aims to enhance social connections and support for seniors, allowing them to live securely and happily at home.

Astra Space, Inc. is a technology company based in Alameda, California, that specializes in designing and building rockets for satellite delivery and launch services. Founded in 2004 and originally known as Ventions LLC, the company rebranded in 2016 and aims to provide accessible and affordable access to space. Astra offers online reservations for payload deliveries to both sun-synchronous and low inclination orbits, with a focus on dedicated launch services for payloads ranging from 50 kg to 150 kg. The business is divided into two segments: Launch Services, which provides rapid global launch capabilities, and Space Products, which includes the development of space products tailored to customer needs for successful satellite launches. Astra operates test facilities to support its operations and is committed to facilitating frequent access to space for satellite operators and governments.

PerimeterX, Inc. is a cybersecurity company that specializes in developing solutions to prevent automated attacks and malicious web behavior. Founded in 2014 and headquartered in San Mateo, California, with additional locations in London, Miami, and a subsidiary in Tel Aviv, the company offers a suite of products aimed at protecting web infrastructure. Its flagship solutions, known as PerimeterX Bot Defender, provide real-time defenses against various types of bot attacks, including those targeting websites, mobile applications, and APIs. By leveraging behavioral analytics and advanced threat detection techniques, PerimeterX helps organizations in sectors such as e-commerce, travel, and media safeguard their digital assets from account abuse, web scraping, and marketing fraud. The company's innovative approach has garnered recognition, including being listed among the top cybersecurity startups and promising artificial intelligence firms.

Steereo Inc. operates a music discovery platform tailored for rideshare drivers, enabling them to entertain passengers with new music during their journeys. Founded in 2017 and based in New York, the company aims to empower artists by providing them with a unique avenue to market their music and connect with new audiences. Through its application, Steereo facilitates exposure for various artists while offering drivers opportunities to earn additional income and rewards. The service is currently available in key markets such as New York and Austin, Texas, creating impactful brand connections and enhancing the rideshare experience.

Qlaris Bio is a clinical-stage biotechnology company based in Wellesley, Massachusetts, founded in 2017. The company specializes in developing innovative therapies for serious and debilitating ophthalmic diseases, with a focus on addressing episcleral venous pressure (EVP), a significant component of intraocular pressure (IOP). Qlaris Bio's lead therapy, QLS-101, aims to reduce IOP, thereby mitigating the risk of blindness in conditions such as Primary Open Angle Glaucoma and Normal Tension Glaucoma. The company also targets other high unmet need conditions related to disturbances in intraocular pressure, including a progressive pediatric rare disease with limited effective therapies.

Homeis Inc. is an online social network designed to connect local foreign-born communities, enabling members to share their culture, local knowledge, and experiences. Founded in 2016 and based in New York, the platform caters to the unique needs of immigrants by fostering digital connections among individuals who share similar backgrounds and interests. Homeis aims to empower these communities by providing a space where users can access tailored services, connect with nearby individuals, and engage in meaningful interactions. The company also develops mobile applications for both Android and iOS, further enhancing accessibility and user experience. Through its innovative approach, Homeis seeks to transform invisible groups into visible communities, addressing the complexities of identity for those who navigate multiple cultural landscapes.

Founded in New York in 2018, Bravo Sierra is a performance wellness company that pioneers user-driven personal care and nutrition products. It collaborates directly with U.S. military active duty service members to deliver responsive and accurate products for both military personnel and civilians.

ScaleFactor provides automated accounting and finance software, offering features such as bookkeeping automation, proactive alerts, and business insights translation. It formerly offered additional services like IT integration, HR/payroll, compliance, and CFO advisory. ScaleFactor served various industries including professional services, restaurants, retail, technology, and wellness. The company was founded in 2014 and had offices across North America before ceasing operations.

Founded in 2017, Superplastic is a Vermont-based company that creates character-based products and entertainment. It designs limited edition art toys, apparel, games, and animation, collaborating with renowned artists to bring unique characters to life.

MindTickle offers a sales readiness platform that enables companies to train, coach, and align their customer-facing teams. Its data-driven approach combines on-demand training, mobile updates, gamification, coaching, role-play, and assessment tools to enhance sales performance. Headquartered in San Francisco and Pune, MindTickle is privately held.

nTopology, Inc. is an engineering software company founded in 2013 and headquartered in New York, New York. The company specializes in developing design software and tools aimed at optimizing manufacturing processes. Its flagship platform, nTopology, empowers engineers to create lightweight and optimized parts that meet specific functional requirements. The software includes features such as Lightweighting, Architected Materials, Topology Optimization, Additive Manufacturing, and Design Analysis, facilitating the integration of geometry and simulation data into manufacturing-ready models. By streamlining workflows and enhancing team collaboration, nTopology serves a diverse range of industries, including aerospace and defense, medical, automotive, consumer products, and education.

Founded in 2019, Resemble AI specializes in developing speech-generating technology. Using proprietary deep-learning models, they create realistic voice clones for various applications, serving primarily the entertainment sector and marketing agencies. Their solutions enable real-time speech-to-speech transformation with granular control over inflections and intonations.

CompStak, Inc., founded in 2011 and headquartered in New York, operates an online platform that provides a comprehensive database of commercial lease comparables. Utilizing a crowd-sourced model, CompStak facilitates the exchange of detailed lease information, which includes tenant names, addresses, rental rates, square footage, landlord concessions, broker identities, and other pertinent data. This information is critical for real estate investors, brokers, asset managers, and appraisers as they conduct valuations and analyses of commercial properties. CompStak's platform serves various stakeholders in the real estate market, enabling informed decision-making in significant investments and property comparisons. Additionally, CompStak has established a strategic partnership with Knowledge Cubed to enhance its data offerings, further solidifying its position in the industry.

Journey Meditation, Inc. specializes in providing a meditation application aimed at individuals and organizations. The company offers the Journey LIVE app, which features group meditation led by live instructors through real-time classes accessible to the public. Users can participate in scheduled video live streams throughout the day, guided by teachers from diverse backgrounds and meditation styles. Founded in 2015 by Stephen Sokoler, Journey Meditation is headquartered in New York, New York. The application is designed to make meditation relatable and accessible to a broad audience, incorporating six impactful Life Lessons to enhance the overall experience.