Cardinal Partners

Cardinal Partners is a venture capital firm founded in 1996 and headquartered in Princeton, New Jersey, with additional offices in Laguna Beach, California, and Wayne, Pennsylvania. The firm specializes in early-stage and high-growth investments, primarily within the healthcare sector, which encompasses healthcare information technology, medical technology, life sciences, medical products, and medical devices. Cardinal Partners focuses on companies based in the United States, particularly in the Mid Atlantic region, and typically invests between $6 million and $12 million as a lead investor in their initial financing rounds. In addition to healthcare, the firm also explores opportunities in consumer sectors, machine learning, and blockchain technology.

John Clarke

General Partner and Founder

John J. Park

Partner and CFO

57 past transactions

Vividion Therapeutics

Series B in 2019
Vividion Therapeutics, Inc. is a biotechnology company based in San Diego, California, that focuses on developing innovative therapeutics to address significant unmet medical needs. Established in 2013, Vividion utilizes a pioneering platform for proteome-wide small molecule drug discovery, which combines advanced synthetic chemistry techniques with chemical proteomics. This approach allows the company to expand the druggable proteome and target challenging proteins, ultimately enabling the discovery of transformative treatments for serious illnesses. Vividion's scientific foundation stems from experts in chemical biology and synthetic chemistry at The Scripps Research Institute, reflecting its commitment to advancing therapeutics that can significantly improve patient outcomes.

Cureatr

Venture Round in 2018
Cureatr Inc. is a New York-based company that specializes in mobile care coordination solutions for healthcare providers. Founded in 2011, it offers a cloud-based medication management software designed to optimize patient care, particularly focusing on post-discharge medication reconciliation. The platform combines HIPAA-secure text messaging with workflow navigation tools, facilitating communication and coordination among healthcare professionals. Cureatr's software features an inbuilt dashboard that curates and analyzes patients' medication history, enabling providers to respond to real-time events and improve their interactions with patients. By streamlining these processes, Cureatr enhances the overall quality of patient care.

Prealize Health

Series A in 2017
Prealize Health is a healthcare technology company based in Palo Alto, California, founded in 2015. It specializes in utilizing machine learning to shift healthcare from a reactive model to a proactive one, enabling individuals to lead healthier lives. By predicting high-cost members before they incur significant expenses, Prealize works closely with clinician teams to implement targeted interventions that enhance care quality while managing costs. The company's analytical system integrates artificial intelligence with clinical insights, allowing health plans, employers, and providers to anticipate future health risks and optimize healthcare spending effectively.

Vividion Therapeutics

Series A in 2017
Vividion Therapeutics, Inc. is a biotechnology company based in San Diego, California, that focuses on developing innovative therapeutics to address significant unmet medical needs. Established in 2013, Vividion utilizes a pioneering platform for proteome-wide small molecule drug discovery, which combines advanced synthetic chemistry techniques with chemical proteomics. This approach allows the company to expand the druggable proteome and target challenging proteins, ultimately enabling the discovery of transformative treatments for serious illnesses. Vividion's scientific foundation stems from experts in chemical biology and synthetic chemistry at The Scripps Research Institute, reflecting its commitment to advancing therapeutics that can significantly improve patient outcomes.

Vividion Therapeutics

Series A in 2016
Vividion Therapeutics, Inc. is a biotechnology company based in San Diego, California, that focuses on developing innovative therapeutics to address significant unmet medical needs. Established in 2013, Vividion utilizes a pioneering platform for proteome-wide small molecule drug discovery, which combines advanced synthetic chemistry techniques with chemical proteomics. This approach allows the company to expand the druggable proteome and target challenging proteins, ultimately enabling the discovery of transformative treatments for serious illnesses. Vividion's scientific foundation stems from experts in chemical biology and synthetic chemistry at The Scripps Research Institute, reflecting its commitment to advancing therapeutics that can significantly improve patient outcomes.

lifeIMAGE

Series D in 2015
LifeIMAGE is an online network that enables individuals to exchange medical images. LifeIMAGE is interoperable with the hospital EMR to provide integrated access to medical images, from anywhere. Clinicians can exchange medical images with patients and providers, anywhere. It was founded in 2008 and headquartered in Newton, Massachusetts.

Ivenix

Venture Round in 2015
Ivenix, Inc. is a medical technology company based in North Andover, Massachusetts, that specializes in developing advanced intravenous (IV) infusion systems. Founded in 2001 and previously known as Fluidnet Corporation, Ivenix focuses on creating innovative solutions to improve infusion delivery in hospital settings. The company's flagship product is a next-generation infusion management system that employs pneumatic technology to accurately measure and control fluid flow, regardless of factors such as bag height, backpressure, patient movement, and fluid viscosity. This system not only simplifies the infusion process but also integrates with clinical information systems, enabling healthcare providers to manage patient infusion data effectively. By aiming to enhance the safety and efficiency of IV therapies, Ivenix is positioned to make a significant impact in the field of medical devices.

Cureatr

Series B in 2015
Cureatr Inc. is a New York-based company that specializes in mobile care coordination solutions for healthcare providers. Founded in 2011, it offers a cloud-based medication management software designed to optimize patient care, particularly focusing on post-discharge medication reconciliation. The platform combines HIPAA-secure text messaging with workflow navigation tools, facilitating communication and coordination among healthcare professionals. Cureatr's software features an inbuilt dashboard that curates and analyzes patients' medication history, enabling providers to respond to real-time events and improve their interactions with patients. By streamlining these processes, Cureatr enhances the overall quality of patient care.

lifeIMAGE

Venture Round in 2015
LifeIMAGE is an online network that enables individuals to exchange medical images. LifeIMAGE is interoperable with the hospital EMR to provide integrated access to medical images, from anywhere. Clinicians can exchange medical images with patients and providers, anywhere. It was founded in 2008 and headquartered in Newton, Massachusetts.

aTyr Pharma

Series E in 2015
aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Teladoc Health

Series C in 2014
Teladoc Health is a leading virtual healthcare provider that modernizes access to healthcare services through its telehealth platform. The company offers on-demand medical care via mobile devices, the internet, video, and phone, focusing on delivering high-quality, cost-effective solutions. Teladoc's integrated clinical offerings include telehealth services, expert medical opinions, and remote patient monitoring programs for chronic care management. With a workforce of over 2,000 employees, Teladoc operates in 125 countries and provides services in more than 20 languages. The company collaborates with employers, hospitals, health systems, and insurers to transform healthcare delivery, generating revenue primarily from subscription-based access fees. Additionally, it offers visit fees and equipment rental to hospital systems, ensuring comprehensive care solutions for its members.

Privia Health

Private Equity Round in 2014
Privia Health, LLC is a physician practice management and population health technology company based in Arlington, Virginia, founded in 2007. The company partners with medical groups, health plans, and health systems to enhance physician practices and improve patient experiences. Privia Health offers a cloud-based technology platform designed to optimize healthcare delivery and promote patient engagement. Its services include a high-performance physician group, an accountable care organization, and population health management programs, all aimed at aligning reimbursements with quality outcomes. By focusing on both in-person and virtual care settings, Privia Health seeks to reduce unnecessary healthcare costs and improve patient health and provider well-being. The company maintains strategic alliances with organizations such as Premier Medical Group and Children’s Health, emphasizing its commitment to fostering a healthier patient population through innovative solutions.

Cureatr

Series A in 2013
Cureatr Inc. is a New York-based company that specializes in mobile care coordination solutions for healthcare providers. Founded in 2011, it offers a cloud-based medication management software designed to optimize patient care, particularly focusing on post-discharge medication reconciliation. The platform combines HIPAA-secure text messaging with workflow navigation tools, facilitating communication and coordination among healthcare professionals. Cureatr's software features an inbuilt dashboard that curates and analyzes patients' medication history, enabling providers to respond to real-time events and improve their interactions with patients. By streamlining these processes, Cureatr enhances the overall quality of patient care.

aTyr Pharma

Series D in 2013
aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Sapphire Digital

Series C in 2013
Vitals, now known as Sapphire Digital, is a health care technology company founded in 2007 and headquartered in Lyndhurst, New Jersey, with additional offices in New York, Oklahoma, and New Hampshire. The company specializes in developing solutions that aim to lower health care costs for consumers, employers, and health plans. Its primary offering is an engagement and shopping platform designed to help users navigate health care options effectively. Key features include CareSelect, which assists in locating care and understanding costs; SmartShopper, which incentivizes employees to choose high-quality, cost-effective care; and MEG, which provides quality scores for surgeons and facilities. Additionally, Sapphire 360 enables health plans to negotiate competitive rates and manage expenses through data analytics. Each year, over 280 million individuals utilize these services to make informed health care decisions.

lifeIMAGE

Series C in 2013
LifeIMAGE is an online network that enables individuals to exchange medical images. LifeIMAGE is interoperable with the hospital EMR to provide integrated access to medical images, from anywhere. Clinicians can exchange medical images with patients and providers, anywhere. It was founded in 2008 and headquartered in Newton, Massachusetts.

QPID

Series A in 2013
QPID Health, Inc. is a healthcare IT software company headquartered in Boston, Massachusetts, with an additional location in San Diego, California. The company specializes in a health record intelligence platform known as the Queriable Programmable Inference Dossier (QPID), which was originally developed at Massachusetts General Hospital. This platform enables healthcare institutions and clinicians to extract valuable insights from electronic health records (EHRs) through real-time queries, analytics, and reporting capabilities at the point of care. QPID is designed to be EHR agnostic, automatically delivering context-sensitive information to enhance clinical workflows and decision-making. By utilizing advanced technologies such as natural language processing and machine learning, the platform aims to improve clinician productivity, support informed care decisions, and ultimately enhance patient outcomes while reducing costs. Founded in 2013 by Dr. Michael Zalis and Dr. Mitch Harris, QPID Health is backed by notable investors, including Matrix Partners and the Massachusetts General Physicians Organization.

Vascular Pharmaceuticals

Series A in 2012
Vascular Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing therapeutics for patients with type 1 and type 2 diabetes, specifically targeting complications such as diabetic nephropathy. Founded in 2005 and based in North Carolina, the company is advancing its lead candidate, VPI-2690B, a subcutaneously administered monoclonal antibody designed to respond to hyperglycemia. This innovative treatment aims to bind to a specific molecular target within the αVβ3 receptor, potentially offering patients a means to mitigate the serious complications associated with diabetes. Vascular Pharmaceuticals operates at the intersection of biotechnology, medicine, and healthcare, contributing to the ongoing efforts to improve outcomes for those affected by diabetes.

Awarepoint

Venture Round in 2012
Awarepoint Corporation, established in 2002 and based in San Diego, California, specializes in providing cloud-based real-time locating systems (RTLS) tailored for the healthcare sector and other industries such as manufacturing and retail. The company's solutions enhance operational efficiency by enabling organizations to track assets and streamline workflows, thus addressing critical challenges in asset management, compliance, and patient throughput. Awarepoint integrates software, technology, and managed services into a cohesive platform, allowing healthcare providers to optimize their existing IT investments. Additionally, the company offers a Temperature Monitoring System that helps medical facilities comply with guidelines for vaccine storage. As a leader in workflow automation and tracking solutions, Awarepoint supports healthcare professionals in achieving improved clinical and financial outcomes.

lifeIMAGE

Series B in 2011
LifeIMAGE is an online network that enables individuals to exchange medical images. LifeIMAGE is interoperable with the hospital EMR to provide integrated access to medical images, from anywhere. Clinicians can exchange medical images with patients and providers, anywhere. It was founded in 2008 and headquartered in Newton, Massachusetts.

Medley Health

Series A in 2011
Medley Health is an innovative, entrepreneurial, technology-driven company. It's backed by top-tier investors and a management team with deep business expertise in healthcare, Internet and web services, as well as next-generation communications technologies.

Verastem

Series C in 2011
Verastem, Inc. is a biopharmaceutical company dedicated to developing and commercializing innovative treatments to enhance the survival and quality of life for cancer patients. The company markets COPIKTRA, an oral dual inhibitor of phosphoinositide 3-kinase (PI3K), which is approved for adult patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma after previous therapies. Additionally, Verastem is advancing its pipeline with the focal adhesion kinase inhibitor defactinib, currently being studied in combination with immunotherapies for various cancers, including pancreatic and non-small cell lung cancer. The company focuses on targeting critical signaling pathways in cancer to inhibit tumor growth and promote cell death. Verastem has established collaborations with Yakult Honsha Co., Ltd. and CSPC Pharmaceutical Group Limited, and is headquartered in Needham, Massachusetts.

Teladoc Health

Series A in 2011
Teladoc Health is a leading virtual healthcare provider that modernizes access to healthcare services through its telehealth platform. The company offers on-demand medical care via mobile devices, the internet, video, and phone, focusing on delivering high-quality, cost-effective solutions. Teladoc's integrated clinical offerings include telehealth services, expert medical opinions, and remote patient monitoring programs for chronic care management. With a workforce of over 2,000 employees, Teladoc operates in 125 countries and provides services in more than 20 languages. The company collaborates with employers, hospitals, health systems, and insurers to transform healthcare delivery, generating revenue primarily from subscription-based access fees. Additionally, it offers visit fees and equipment rental to hospital systems, ensuring comprehensive care solutions for its members.

Awarepoint

Series F in 2011
Awarepoint Corporation, established in 2002 and based in San Diego, California, specializes in providing cloud-based real-time locating systems (RTLS) tailored for the healthcare sector and other industries such as manufacturing and retail. The company's solutions enhance operational efficiency by enabling organizations to track assets and streamline workflows, thus addressing critical challenges in asset management, compliance, and patient throughput. Awarepoint integrates software, technology, and managed services into a cohesive platform, allowing healthcare providers to optimize their existing IT investments. Additionally, the company offers a Temperature Monitoring System that helps medical facilities comply with guidelines for vaccine storage. As a leader in workflow automation and tracking solutions, Awarepoint supports healthcare professionals in achieving improved clinical and financial outcomes.

Fluidnet

Series C in 2011
Fluidnet was founded in 2002 by a group of medical device professionals who collectively have over 100+ years of industry experience and product innovations. Based on the seacoast of scenic New Hampshire, Fluidnet is just north of Boston, providing access to a rich medical device community and first-rate research and development skills and facilities.

Verastem

Series B in 2011
Verastem, Inc. is a biopharmaceutical company dedicated to developing and commercializing innovative treatments to enhance the survival and quality of life for cancer patients. The company markets COPIKTRA, an oral dual inhibitor of phosphoinositide 3-kinase (PI3K), which is approved for adult patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma after previous therapies. Additionally, Verastem is advancing its pipeline with the focal adhesion kinase inhibitor defactinib, currently being studied in combination with immunotherapies for various cancers, including pancreatic and non-small cell lung cancer. The company focuses on targeting critical signaling pathways in cancer to inhibit tumor growth and promote cell death. Verastem has established collaborations with Yakult Honsha Co., Ltd. and CSPC Pharmaceutical Group Limited, and is headquartered in Needham, Massachusetts.

lifeIMAGE

Series B in 2011
LifeIMAGE is an online network that enables individuals to exchange medical images. LifeIMAGE is interoperable with the hospital EMR to provide integrated access to medical images, from anywhere. Clinicians can exchange medical images with patients and providers, anywhere. It was founded in 2008 and headquartered in Newton, Massachusetts.

Awarepoint

Venture Round in 2010
Awarepoint Corporation, established in 2002 and based in San Diego, California, specializes in providing cloud-based real-time locating systems (RTLS) tailored for the healthcare sector and other industries such as manufacturing and retail. The company's solutions enhance operational efficiency by enabling organizations to track assets and streamline workflows, thus addressing critical challenges in asset management, compliance, and patient throughput. Awarepoint integrates software, technology, and managed services into a cohesive platform, allowing healthcare providers to optimize their existing IT investments. Additionally, the company offers a Temperature Monitoring System that helps medical facilities comply with guidelines for vaccine storage. As a leader in workflow automation and tracking solutions, Awarepoint supports healthcare professionals in achieving improved clinical and financial outcomes.

Verastem

Series A in 2010
Verastem, Inc. is a biopharmaceutical company dedicated to developing and commercializing innovative treatments to enhance the survival and quality of life for cancer patients. The company markets COPIKTRA, an oral dual inhibitor of phosphoinositide 3-kinase (PI3K), which is approved for adult patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma after previous therapies. Additionally, Verastem is advancing its pipeline with the focal adhesion kinase inhibitor defactinib, currently being studied in combination with immunotherapies for various cancers, including pancreatic and non-small cell lung cancer. The company focuses on targeting critical signaling pathways in cancer to inhibit tumor growth and promote cell death. Verastem has established collaborations with Yakult Honsha Co., Ltd. and CSPC Pharmaceutical Group Limited, and is headquartered in Needham, Massachusetts.

aTyr Pharma

Series C in 2010
aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Fluidnet

Series B in 2010
Fluidnet was founded in 2002 by a group of medical device professionals who collectively have over 100+ years of industry experience and product innovations. Based on the seacoast of scenic New Hampshire, Fluidnet is just north of Boston, providing access to a rich medical device community and first-rate research and development skills and facilities.

Awarepoint

Series E in 2010
Awarepoint Corporation, established in 2002 and based in San Diego, California, specializes in providing cloud-based real-time locating systems (RTLS) tailored for the healthcare sector and other industries such as manufacturing and retail. The company's solutions enhance operational efficiency by enabling organizations to track assets and streamline workflows, thus addressing critical challenges in asset management, compliance, and patient throughput. Awarepoint integrates software, technology, and managed services into a cohesive platform, allowing healthcare providers to optimize their existing IT investments. Additionally, the company offers a Temperature Monitoring System that helps medical facilities comply with guidelines for vaccine storage. As a leader in workflow automation and tracking solutions, Awarepoint supports healthcare professionals in achieving improved clinical and financial outcomes.

Teladoc Health

Series A in 2009
Teladoc Health is a leading virtual healthcare provider that modernizes access to healthcare services through its telehealth platform. The company offers on-demand medical care via mobile devices, the internet, video, and phone, focusing on delivering high-quality, cost-effective solutions. Teladoc's integrated clinical offerings include telehealth services, expert medical opinions, and remote patient monitoring programs for chronic care management. With a workforce of over 2,000 employees, Teladoc operates in 125 countries and provides services in more than 20 languages. The company collaborates with employers, hospitals, health systems, and insurers to transform healthcare delivery, generating revenue primarily from subscription-based access fees. Additionally, it offers visit fees and equipment rental to hospital systems, ensuring comprehensive care solutions for its members.

Inspired Technologies

Series B in 2009
Inspired Technologies, based in North Huntingdon, PA, is a commercial-stage medical device company specializing in respiratory products for patients with chronic obstructive pulmonary disease (COPD). The company develops innovative solutions such as personal oxygen portables featuring SmartDose technology, which continuously monitors a user's breath rate and automatically adjusts oxygen delivery based on their activity level. Additionally, Inspired Technologies provides Clinical Oxygen Dose Recorders that allow healthcare providers to monitor patient responses and optimize performance in real time. Their offerings also include Viaspire SD Card Software, which facilitates the upload and analysis of patient data from SmartDose units, enhancing the management of oxygen therapy for COPD patients.

aTyr Pharma

Series C in 2009
aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Awarepoint

Series D in 2008
Awarepoint Corporation, established in 2002 and based in San Diego, California, specializes in providing cloud-based real-time locating systems (RTLS) tailored for the healthcare sector and other industries such as manufacturing and retail. The company's solutions enhance operational efficiency by enabling organizations to track assets and streamline workflows, thus addressing critical challenges in asset management, compliance, and patient throughput. Awarepoint integrates software, technology, and managed services into a cohesive platform, allowing healthcare providers to optimize their existing IT investments. Additionally, the company offers a Temperature Monitoring System that helps medical facilities comply with guidelines for vaccine storage. As a leader in workflow automation and tracking solutions, Awarepoint supports healthcare professionals in achieving improved clinical and financial outcomes.

CodeRyte

Series D in 2008
CodeRyte is a leading provider of computer-assisted coding and clinical data extraction solutions tailored for the healthcare industry. The company offers advanced software that automates the coding process and efficiently analyzes physician narratives to uncover critical clinical information. Their product suite includes CodeAssist, a web-based tool that streamlines coding by integrating with operational information systems, CodeComplete, an outsourced coding solution, and DataScout, which extracts valuable clinical data from both free-text and structured medical records. CodeRyte's technology helps healthcare providers improve reimbursement accuracy, enhance compliance, and boost operational efficiency, making it a trusted partner for numerous physician practices, billing companies, and academic medical centers across the nation.

Axogen

Post in 2007
AxoGen, Inc. is a company focused on developing and commercializing innovative solutions for the repair and regeneration of peripheral nerve injuries. Based in Alachua, Florida, and founded in 2002, AxoGen offers a range of products designed for effective surgical procedures, including the AVANCE Nerve Graft, Axoguard Nerve Connector, Axoguard Nerve Protector, Axoguard Nerve Cap, and Avive Soft Tissue Membrane. Additionally, it provides the Axotouch Two-Point Discriminator, a device used to assess the innervation density of skin. AxoGen's offerings are aimed at surgeons and healthcare providers, ensuring clinically and economically effective solutions for nerve repair. The company also has a strategic partnership with the American Tissue Services Foundation for tissue recovery and distributes its products across the United States and several international markets, including Canada, Germany, the United Kingdom, Spain, and South Korea.

Inspired Technologies

Series A in 2007
Inspired Technologies, based in North Huntingdon, PA, is a commercial-stage medical device company specializing in respiratory products for patients with chronic obstructive pulmonary disease (COPD). The company develops innovative solutions such as personal oxygen portables featuring SmartDose technology, which continuously monitors a user's breath rate and automatically adjusts oxygen delivery based on their activity level. Additionally, Inspired Technologies provides Clinical Oxygen Dose Recorders that allow healthcare providers to monitor patient responses and optimize performance in real time. Their offerings also include Viaspire SD Card Software, which facilitates the upload and analysis of patient data from SmartDose units, enhancing the management of oxygen therapy for COPD patients.

aTyr Pharma

Series B in 2007
aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Bioconnect Systems

Series A in 2007
Bioconnect Systems, established in 2006 and headquartered in Fort Washington, Pennsylvania, specializes in developing innovative surgical implants and techniques aimed at creating controlled vascular connections. The company's flagship product, the Optiflow family of sutureless anastomotic connectors, offers a rapid and reliable solution for connecting blood vessels. These advancements significantly enhance the performance of arteriovenous fistulae and vascular access grafts, particularly benefiting patients with renal diseases by streamlining the vessel connection process.

Melinta Therapeutics

Series C in 2006
Melinta Therapeutics, Inc. is a commercial-stage pharmaceutical company based in Morristown, New Jersey, specializing in the discovery, development, and commercialization of anti-infective therapies for bacterial infections in North America. The company offers a range of antibiotics, including Baxdela, Vabomere, Orbactiv, and Minocin, targeting various serious bacterial infections such as acute bacterial skin and skin structure infections (ABSSSIs) and gram-negative infections. Melinta is actively advancing its investigational antibiotic, delafloxacin, which is currently in Phase 3 development for ABSSSIs. Additionally, the company is engaged in research to develop new classes of antibiotics aimed at combating drug-resistant pathogens, particularly the ESKAPE group responsible for many hospital-acquired infections. Through its innovative approaches, Melinta Therapeutics addresses the urgent need for new therapies against drug-resistant infections, a critical public health challenge today.

CodeRyte

Series C in 2006
CodeRyte is a leading provider of computer-assisted coding and clinical data extraction solutions tailored for the healthcare industry. The company offers advanced software that automates the coding process and efficiently analyzes physician narratives to uncover critical clinical information. Their product suite includes CodeAssist, a web-based tool that streamlines coding by integrating with operational information systems, CodeComplete, an outsourced coding solution, and DataScout, which extracts valuable clinical data from both free-text and structured medical records. CodeRyte's technology helps healthcare providers improve reimbursement accuracy, enhance compliance, and boost operational efficiency, making it a trusted partner for numerous physician practices, billing companies, and academic medical centers across the nation.

CardioOptics

Series B in 2005
CardioOptics is a development-stage medical device company based in Boulder.

Sirtris Pharmaceuticals

Series B in 2005
[Sirtris Pharmaceuticals](http://www.sirtrispharma.com) (NASDAQ: SIRT) is a biopharmaceutical company focused on discovering and developing proprietary, orally available, small molecule drugs with the potential to treat diseases associated with aging, including metabolic diseases such as Type 2 Diabetes. via: [Sirtris](http://www.sirtrispharma.com)

Roving Planet

Series C in 2005
Roving Planet, Inc. provides network access control and management solutions for enterprise networks. Its products provide a secure network environment by managing and controlling users, endpoints, connections, and sessions. The company serves enterprise, manufacturing, health, higher education, k-12, and aerospace government industries. Roving Planet, Inc. was founded in 2001 and is headquartered in Westminster, Colorado.

Sirtris Pharmaceuticals

Series A in 2004
[Sirtris Pharmaceuticals](http://www.sirtrispharma.com) (NASDAQ: SIRT) is a biopharmaceutical company focused on discovering and developing proprietary, orally available, small molecule drugs with the potential to treat diseases associated with aging, including metabolic diseases such as Type 2 Diabetes. via: [Sirtris](http://www.sirtrispharma.com)

Momenta Pharmaceuticals

Series C in 2004
Momenta Pharmaceuticals, Inc. is a biotechnology company headquartered in Cambridge, Massachusetts, that focuses on the discovery and development of innovative therapeutics for rare immune-mediated diseases. The company's product pipeline includes novel therapeutics such as M281, a fully-human monoclonal antibody targeting the neonatal Fc receptor to reduce circulating IgG antibodies; M254, aimed at treating inflammatory diseases; and M230, a recombinant trivalent IgG1 Fc multimer designed for enhanced therapeutic activity. Additionally, Momenta has developed complex generic products, including M-Enoxaparin, a generic version of Lovenox, and M356, a generic of Copaxone for multiple sclerosis. Momenta also has biosimilar programs, including M923, a biosimilar of HUMIRA, and M710, a biosimilar of EYLEA for various eye conditions. Despite previously pursuing the generics and biosimilars market, the company shifted its focus to innovative drug development, with several promising candidates in the pipeline for autoimmune diseases. Momenta was founded in 2001 and operates as a subsidiary of Johnson & Johnson.

Alnylam Pharmaceuticals

Venture Round in 2003
Alnylam Pharmaceuticals is a biopharmaceutical company specializing in the discovery, development, and commercialization of RNA interference (RNAi) therapeutics. The company focuses on addressing rare genetic diseases, cardio-metabolic conditions, hepatic infectious diseases, and central nervous system/ocular disorders. Its marketed products include ONPATTRO, a treatment for hereditary transthyretin-mediated amyloidosis, and GIVLAARI, which targets acute hepatic porphyria. Alnylam’s pipeline includes investigational therapies such as givosiran for acute hepatic porphyria, lumasiran for primary hyperoxaluria type 1, and vutrisiran for transthyretin amyloidosis. The company has established strategic alliances with notable partners like Sanofi Genzyme and Regeneron Pharmaceuticals, and it collaborates with Vir Biotechnology on RNAi therapeutics for coronavirus infections. Founded in 2002 and headquartered in Cambridge, Massachusetts, Alnylam Pharmaceuticals is at the forefront of transforming RNAi science into innovative medicines to improve patient outcomes.

Momenta Pharmaceuticals

Series B in 2003
Momenta Pharmaceuticals, Inc. is a biotechnology company headquartered in Cambridge, Massachusetts, that focuses on the discovery and development of innovative therapeutics for rare immune-mediated diseases. The company's product pipeline includes novel therapeutics such as M281, a fully-human monoclonal antibody targeting the neonatal Fc receptor to reduce circulating IgG antibodies; M254, aimed at treating inflammatory diseases; and M230, a recombinant trivalent IgG1 Fc multimer designed for enhanced therapeutic activity. Additionally, Momenta has developed complex generic products, including M-Enoxaparin, a generic version of Lovenox, and M356, a generic of Copaxone for multiple sclerosis. Momenta also has biosimilar programs, including M923, a biosimilar of HUMIRA, and M710, a biosimilar of EYLEA for various eye conditions. Despite previously pursuing the generics and biosimilars market, the company shifted its focus to innovative drug development, with several promising candidates in the pipeline for autoimmune diseases. Momenta was founded in 2001 and operates as a subsidiary of Johnson & Johnson.

NexCura

Series C in 2002
NexCura specializes in online decision support services tailored for patient communities, offering applications and custom services through an application service provider model. The company's platforms facilitate the collection of comprehensive clinical data, enhancing communication between patients and their physicians. It provides valuable resources such as patient education and market research services. Additionally, NexCura's NexProfiler tools assist in pre-treatment decision-making by integrating clinical evidence with personal concerns and the unique clinical circumstances of individual patients. This aggregated data serves to benefit healthcare organizations, pharmaceutical companies, physicians, and patients alike.

CardioOptics

Series A in 2002
CardioOptics is a development-stage medical device company based in Boulder.

IntelliCare

Series B in 2002
Providing 24-hour healthcare these days is a tough balancing act. Don't perform without a safety net you can trust. At IntelliCare, they know the ropes. They're a management company for medical call centers, and they work closely with health systems, provider networks and physician groups to make their operations a success. They offer experience, flexibility, commitment -- and a wide range of 24-hour telephonic and Web-based medical call center services that let you focus on what you do best. Making people feel better.

IntelliCare

Venture Round in 2000
Providing 24-hour healthcare these days is a tough balancing act. Don't perform without a safety net you can trust. At IntelliCare, they know the ropes. They're a management company for medical call centers, and they work closely with health systems, provider networks and physician groups to make their operations a success. They offer experience, flexibility, commitment -- and a wide range of 24-hour telephonic and Web-based medical call center services that let you focus on what you do best. Making people feel better.

IC-USA

Series B in 2000
IC-USA is a business consulting firm that assists both domestic and foreign nationals in establishing investments. It also offers passive investments for investing, which refers broadly to a buy-and-hold portfolio strategy for long-term investment.

Pointshare

Series C in 1999
Pointshare is a national leader in connecting local healthcare communities with secure, online business services that enhance communication, create efficiencies, and improve the delivery of care. Pointshare is the only company that has developed the technology, infrastructure, and hands-on service to create a proven, practical solution for automating the day-to-day business transactions of healthcare.

Pointshare

Series B in 1999
Pointshare is a national leader in connecting local healthcare communities with secure, online business services that enhance communication, create efficiencies, and improve the delivery of care. Pointshare is the only company that has developed the technology, infrastructure, and hands-on service to create a proven, practical solution for automating the day-to-day business transactions of healthcare.
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