Ayuh Ventures

Founded in 2021, Samphire Neuroscience specializes in developing neurotechnological solutions for women's health. Its flagship product is a non-invasive headband device that uses electrical neuromodulation to alleviate symptoms such as pain, fatigue, and mood changes associated with menstrual cycles.

Founded in 2021, Samphire Neuroscience specializes in developing neurotechnological solutions for women's health. Its flagship product is a non-invasive headband device that uses electrical neuromodulation to alleviate symptoms such as pain, fatigue, and mood changes associated with menstrual cycles.

Kadence Bio is a clinical-stage life sciences company developing novel therapeutics, with a focus on small molecule programs addressing sexual and mental well-being. Its lead compound KH-001 is being developed as a treatment for premature ejaculation, reflecting the company’s aim to provide additional options for patients and expand therapeutic opportunities in areas with significant unmet need.

Gilgamesh Pharmaceuticals, Inc. is a preclinical biotechnology company based in New York, focused on developing innovative psychotropic drugs to address mental health issues. Founded in 2019, the company specializes in creating novel compounds that enhance the benefits of traditional psychedelics, improving parameters such as safety, tolerability, duration, and efficacy. Gilgamesh targets a range of neuropsychiatric conditions, including depression, anxiety, substance use disorders, and stress-related issues. With the growing global mental health crisis, the company aims to accelerate the development of new treatments that meet the urgent need for effective solutions in mental health care, leveraging its expertise in medicinal chemistry and drug development.

Psy Therapeutics is a biopharmaceutical company dedicated to discovering and developing innovative therapies for central nervous system (CNS) disorders. The company specializes in addressing conditions such as anxiety, depression, and dementia, aiming to enhance neuropsychiatric care. Psy Therapeutics employs a research strategy that focuses on identifying effective drug targets and utilizes advanced screening platforms to facilitate the development of its therapeutic candidates. By leveraging a flexible approach to research and development, the company seeks to provide healthcare professionals with effective treatment options that address critical CNS disorders.

Reset Pharmaceuticals is a biotechnology company dedicated to developing and commercializing innovative psychedelic treatments for patients facing life-threatening illnesses, particularly cancer. The company's primary focus is on psilocybin combined with psychotherapy to address issues such as demoralization, anxiety, and depression in patients suffering from cancer. By leveraging advanced technology, Reset Pharmaceuticals aims to create therapeutics that not only improve mental health outcomes for terminal patients but also enhance their overall quality of life.

Clerkenwell Health is a mental health company providing clinical research support services and psychedelic-assisted therapies. It operates as a psychedelic-specialist contract research organization focused on psychiatry and central nervous system conditions, delivering independent CRO services to advance the adoption of psychedelic treatments in Europe. The company runs a healthcare clinic offering preparation, treatment sessions, and follow-up by experienced psychotherapists, and it collaborates to produce robust, clinically validated data sets that demonstrate the efficacy of psilocybin-assisted therapy relative to existing standards of care. By centering patients in trial design and therapy protocols, Clerkenwell Health aims to improve outcomes while supporting rigorous evaluation of novel psychedelic interventions.

Lief Therapeutics is a medical device company based in San Francisco, California, focused on enhancing at-home care for individuals dealing with post-traumatic stress disorder, depression, and anxiety. The company has developed a discreet bio-sensing patch that accurately measures heart rate and breath, allowing users to manage their natural stress response through vibratory biofeedback exercises. This wearable device helps users monitor their behaviors, emotions, and thoughts in real-time, fostering mindfulness and control throughout the day. Additionally, it supports clinicians by tracking patient progress, facilitating in-session training, and scheduling psychological assessments. Lief Therapeutics also offers the Lief Health Score application, which records thoughts, emotions, and sensations, enabling users to track daily progress and engage in tailored exercises. Founded in 2014, the company sells its products online, aiming to empower individuals in their mental health journeys.