Chiesi Farmaceutici

Amryt Pharma is a biopharmaceutical company dedicated to developing and commercializing innovative therapeutics for patients with serious and life-threatening rare diseases. Founded in 2015 and based in London, the company offers several commercial products, including Myalept, which treats complications related to leptin deficiency in patients with generalized lipodystrophy, and Lojuxta, a medication for adults with homozygous familial hypercholesterolemia. Amryt Pharma is also advancing its research pipeline, including FILSUVEZ, aimed at treating the skin manifestations of epidermolysis bullosa, and AP103, a pre-clinical gene therapy for recessive dystrophic epidermolysis bullosa. The company markets its products across the Americas, Europe, and the Middle East, focusing on addressing high unmet medical needs in rare and orphan diseases.

Cyclica Inc. is a Toronto-based company that specializes in enhancing the drug discovery process through its integrated cloud-based platform augmented by artificial intelligence. Founded in 2010, Cyclica offers technologies such as Ligand Design, which generates novel molecules and evaluates their properties, and Ligand Express, a platform that screens small-molecule drugs against structurally-characterized proteins to assess poly-pharmacological profiles. The company's innovative software leverages biophysics and AI to identify potential ligand-protein interactions, enabling health institutions to prioritize candidate drugs, clarify adverse effects, and explore drug repurposing opportunities. Cyclica has also established a strategic partnership with AUM Biosciences to further its mission of improving drug discovery practices.

Atopix Therapeutics Limited is a clinical-stage biopharmaceutical company based in Oxford, United Kingdom, focused on developing innovative anti-inflammatory medicines for the treatment of asthma, chronic allergic conditions, and other atopic diseases. Founded in 2012, the company specializes in a novel class of oral anti-allergic medications known as CRTH2 antagonists. Its lead candidate is currently undergoing a Phase 2 clinical trial aimed at addressing moderate to severe atopic dermatitis, with studies being conducted at several prominent dermatology centers across Europe. Atopix Therapeutics operates as a subsidiary of Chiesi Farmaceutici S.p.A.

Cornerstone Therapeutics Inc. (NASDAQ: CRTX), headquartered in Cary, N.C., is a specialty pharmaceutical company focused on developing, acquiring, and commercializing products for the respiratory, hospital and related specialty markets. Key elements of the Company's strategy are to focus on identifying therapeutic niches within respiratory, hospital and related specialty markets to leverage existing business and create new opportunities; promote the Company's current products to high prescribing physicians through the Company's respiratory sales force and to hospital-based healthcare professionals through the Company's hospital sales force; license or acquire rights to existing patent- or trade secret-protected, branded products, which can be promoted through the same channels to generate on-going high-value earnings streams; advance the Company's development projects and further build a robust pipeline; and generate revenues by marketing approved generic products through the Company's wholly owned subsidiary, Aristos Pharmaceuticals, Inc.

Zymenex is a Scandinavian biopharmaceutical company dedicated to the development and commercialization of novel enzyme replacement therapies aimed at treating life-threatening rare genetic diseases. The company focuses on creating human recombinant enzymes to address specific disease areas, particularly Lysosomal Storage Diseases, which impair the body's ability to break down certain molecules in the lysosomes of cells. These diseases often affect children and are associated with serious health challenges, reduced quality of life, and significantly lower life expectancy, with currently no available therapies. Zymenex's commitment to research and development positions it within a validated treatment framework, as enzyme replacement therapy is a recognized approach with existing market products.

uniQure is a pioneering gene therapy company recognized for developing the first gene therapy product to receive regulatory approval in the European Union. Its initial product, Glybera, was authorized in October 2012 for treating patients with lipoprotein lipase deficiency, a rare and severe metabolic disorder. uniQure specializes in creating innovative gene therapies that offer long-term and potentially curative benefits for genetic and acquired diseases. The company utilizes a modular technology platform and a proprietary manufacturing process to develop its treatments. Currently, uniQure is expanding its pipeline of adeno-associated virus (AAV)-based gene therapies, focusing on conditions such as hemophilia, Huntington's disease, and cardiovascular diseases through collaborations, including one with Bristol Myers Squibb. While the company initially targets orphan diseases, it also aims to address chronic and degenerative diseases affecting larger populations.

Cornerstone Therapeutics Inc. (NASDAQ: CRTX), headquartered in Cary, N.C., is a specialty pharmaceutical company focused on developing, acquiring, and commercializing products for the respiratory, hospital and related specialty markets. Key elements of the Company's strategy are to focus on identifying therapeutic niches within respiratory, hospital and related specialty markets to leverage existing business and create new opportunities; promote the Company's current products to high prescribing physicians through the Company's respiratory sales force and to hospital-based healthcare professionals through the Company's hospital sales force; license or acquire rights to existing patent- or trade secret-protected, branded products, which can be promoted through the same channels to generate on-going high-value earnings streams; advance the Company's development projects and further build a robust pipeline; and generate revenues by marketing approved generic products through the Company's wholly owned subsidiary, Aristos Pharmaceuticals, Inc.