City Hill Ventures

Maze Therapeutics is a biotechnology company based in South San Francisco, California, focused on developing innovative medicines that leverage the effects of rare genetic variants to address unmet medical needs. Founded in 2017 and originally known as Modulus Therapeutics, the company utilizes its proprietary Compass platform to identify genetic variants linked to diseases and map them to the biological pathways that drive these conditions in specific patient populations. By integrating large-scale human genetics data and functional genomics with various drug discovery methods, Maze Therapeutics aims to reveal modifier genes that offer protective benefits. This approach enhances the understanding of target biology and informs the development of novel therapies, ultimately enabling pharmaceutical companies to create effective treatments.

Viron is a biopharmaceutical company focused on developing innovative therapies aimed at addressing a range of serious health conditions, including cancer, Alzheimer's, diabetes, neurological, digestive, and immune disorders. Utilizing advanced technologies such as genomics, gene editing, stem cell biology, and artificial intelligence, Viron aims to identify and create high-value therapies targeting specific protein and lipid pathways. The company's approach emphasizes the use of patient-derived organoids and high-throughput screening methods to enhance drug discovery. By leveraging these breakthroughs, Viron seeks to transform treatment paradigms and improve patient outcomes in various diseases.

Viron is a biopharmaceutical company focused on developing innovative therapies aimed at addressing a range of serious health conditions, including cancer, Alzheimer's, diabetes, neurological, digestive, and immune disorders. Utilizing advanced technologies such as genomics, gene editing, stem cell biology, and artificial intelligence, Viron aims to identify and create high-value therapies targeting specific protein and lipid pathways. The company's approach emphasizes the use of patient-derived organoids and high-throughput screening methods to enhance drug discovery. By leveraging these breakthroughs, Viron seeks to transform treatment paradigms and improve patient outcomes in various diseases.

Erasca, Inc. is a clinical-stage precision oncology company based in San Diego, California, focused on discovering and developing therapies for cancers driven by the RAS/MAPK pathway. Founded in 2018, the company utilizes its artificial intelligence-driven oncology pattern recognition algorithm (OPRA) to analyze extensive datasets and uncover novel tumor biology, which aids in the identification of key oncogenes. Erasca's drug development pipeline includes Naporafenib, a pan-RAF inhibitor with potential applications in NRAS mutant melanoma and other RAS/MAPK pathway-driven tumors, as well as ERAS-007, an oral ERK1/2 inhibitor, and ERAS-601, an oral SHP2 inhibitor. The company aims to provide precision oncology options through collaborations with academic and biopharmaceutical partners, ultimately seeking to offer innovative treatment solutions for patients.

Maze Therapeutics is a biotechnology company based in South San Francisco, California, focused on developing innovative medicines that leverage the effects of rare genetic variants to address unmet medical needs. Founded in 2017 and originally known as Modulus Therapeutics, the company utilizes its proprietary Compass platform to identify genetic variants linked to diseases and map them to the biological pathways that drive these conditions in specific patient populations. By integrating large-scale human genetics data and functional genomics with various drug discovery methods, Maze Therapeutics aims to reveal modifier genes that offer protective benefits. This approach enhances the understanding of target biology and informs the development of novel therapies, ultimately enabling pharmaceutical companies to create effective treatments.

Boundless Bio is a clinical-stage biopharmaceutical company focused on developing innovative therapies for the treatment of aggressive cancers linked to extrachromosomal DNA (ecDNA). Founded in 2018 and based in La Jolla, California, the company aims to address the significant unmet medical needs of patients with oncogene amplified tumors, which affect over 14% of cancer patients. By targeting ecDNA, a key factor in oncogene amplification, Boundless Bio seeks to provide transformative treatments for previously difficult-to-treat cancers. One of its leading candidates, BBI-355, is an oral, selective inhibitor of checkpoint kinase 1 (CHK1), designed to manage the replication and transcription of ecDNA in cancer cells.

Viron is a biopharmaceutical company focused on developing innovative therapies aimed at addressing a range of serious health conditions, including cancer, Alzheimer's, diabetes, neurological, digestive, and immune disorders. Utilizing advanced technologies such as genomics, gene editing, stem cell biology, and artificial intelligence, Viron aims to identify and create high-value therapies targeting specific protein and lipid pathways. The company's approach emphasizes the use of patient-derived organoids and high-throughput screening methods to enhance drug discovery. By leveraging these breakthroughs, Viron seeks to transform treatment paradigms and improve patient outcomes in various diseases.

Erasca, Inc. is a clinical-stage precision oncology company based in San Diego, California, focused on discovering and developing therapies for cancers driven by the RAS/MAPK pathway. Founded in 2018, the company utilizes its artificial intelligence-driven oncology pattern recognition algorithm (OPRA) to analyze extensive datasets and uncover novel tumor biology, which aids in the identification of key oncogenes. Erasca's drug development pipeline includes Naporafenib, a pan-RAF inhibitor with potential applications in NRAS mutant melanoma and other RAS/MAPK pathway-driven tumors, as well as ERAS-007, an oral ERK1/2 inhibitor, and ERAS-601, an oral SHP2 inhibitor. The company aims to provide precision oncology options through collaborations with academic and biopharmaceutical partners, ultimately seeking to offer innovative treatment solutions for patients.

Bonti, Inc. is a biotechnology company based in Newport Beach, California, specializing in the development of neurotoxin products for both aesthetic and therapeutic applications. Founded in 2015 and previously known as Endurance Biotech, Bonti focuses on botulinum neurotoxin serotype E, with its key products including EB-001A for aesthetic use and EB-001T for therapeutic purposes. The company's innovations aim to address unmet medical needs, particularly in treating muscle hyperactivity, which is a significant cause of musculoskeletal pain in various patient populations. Bonti's neurotoxin offers a long-acting, non-opioid local muscle relaxant option, designed to minimize the side effects associated with existing treatments. As of October 2018, Bonti operates as a subsidiary of Allergan plc.

Bonti, Inc. is a biotechnology company based in Newport Beach, California, specializing in the development of neurotoxin products for both aesthetic and therapeutic applications. Founded in 2015 and previously known as Endurance Biotech, Bonti focuses on botulinum neurotoxin serotype E, with its key products including EB-001A for aesthetic use and EB-001T for therapeutic purposes. The company's innovations aim to address unmet medical needs, particularly in treating muscle hyperactivity, which is a significant cause of musculoskeletal pain in various patient populations. Bonti's neurotoxin offers a long-acting, non-opioid local muscle relaxant option, designed to minimize the side effects associated with existing treatments. As of October 2018, Bonti operates as a subsidiary of Allergan plc.

Flex Pharma, Inc. is a biotechnology company focused on developing and commercializing treatments for muscle cramps, spasms, and spasticity linked to neurological conditions and exercise. The company operates in two segments: Consumer Operations and Drug Development. Its lead drug candidate, FLX-787, is a dual transient receptor potential V1/A1 ion channel activator, which has completed an exploratory Phase II clinical trial in Australia targeting multiple sclerosis patients. Additionally, Flex Pharma offers HOTSHOT, a consumer beverage designed to prevent and treat exercise-associated muscle cramps. The company markets HOTSHOT products online through its direct-to-consumer website and third-party platforms that provide international shipping. Founded in 2014 and based in Boston, Massachusetts, Flex Pharma was acquired by Salarius Pharmaceuticals in 2019.

Independa, Inc. is a company that develops cloud-based software solutions aimed at enhancing the well-being and social engagement of senior citizens. Its primary offerings include AnyTV Companion, a remote care platform that facilitates social interaction and provides medication reminders, appointment notifications, and monitoring capabilities. The company also offers CloudCare, an enterprise solution that integrates various modules for remote care and community involvement, along with a caregiver dashboard that simplifies monitoring and support for care recipients. Additionally, the Angela solution addresses the challenges faced by seniors wishing to maintain their independence. Independa’s software features smart reminders for events and activities, a broadcast messaging system for alerts and updates, and integrated monitoring to track health and safety. Founded in 2009 and based in San Diego, California, the company serves a range of clients, including senior living communities, hospitals, and home care organizations, and has formed a strategic partnership with LG Electronics to enhance its service offerings.

Independa, Inc. is a company that develops cloud-based software solutions aimed at enhancing the well-being and social engagement of senior citizens. Its primary offerings include AnyTV Companion, a remote care platform that facilitates social interaction and provides medication reminders, appointment notifications, and monitoring capabilities. The company also offers CloudCare, an enterprise solution that integrates various modules for remote care and community involvement, along with a caregiver dashboard that simplifies monitoring and support for care recipients. Additionally, the Angela solution addresses the challenges faced by seniors wishing to maintain their independence. Independa’s software features smart reminders for events and activities, a broadcast messaging system for alerts and updates, and integrated monitoring to track health and safety. Founded in 2009 and based in San Diego, California, the company serves a range of clients, including senior living communities, hospitals, and home care organizations, and has formed a strategic partnership with LG Electronics to enhance its service offerings.

Ignyta, Inc. is a biotechnology company focused on discovering, developing, and commercializing molecularly targeted therapies aimed at treating cancer and autoimmune diseases. Established in 2011 and based in San Diego, California, Ignyta is dedicated to advancing personalized medicine by integrating therapeutic approaches with companion diagnostics. Its notable products include entrectinib, a tyrosine kinase inhibitor targeting various receptor proteins, and RXDX-105, which is designed for RET-driven solid tumors. The company seeks to improve treatment outcomes by identifying patients most likely to benefit from specific therapies through biomarker-based diagnostics. In 2018, Ignyta became a subsidiary of Roche Holdings, further enhancing its capabilities in precision medicine.

Independa, Inc. is a company that develops cloud-based software solutions aimed at enhancing the well-being and social engagement of senior citizens. Its primary offerings include AnyTV Companion, a remote care platform that facilitates social interaction and provides medication reminders, appointment notifications, and monitoring capabilities. The company also offers CloudCare, an enterprise solution that integrates various modules for remote care and community involvement, along with a caregiver dashboard that simplifies monitoring and support for care recipients. Additionally, the Angela solution addresses the challenges faced by seniors wishing to maintain their independence. Independa’s software features smart reminders for events and activities, a broadcast messaging system for alerts and updates, and integrated monitoring to track health and safety. Founded in 2009 and based in San Diego, California, the company serves a range of clients, including senior living communities, hospitals, and home care organizations, and has formed a strategic partnership with LG Electronics to enhance its service offerings.

Eclipse Therapeutics, Inc. is a private biotechnology company focused on discovering and developing innovative therapeutics aimed at targeting cancer stem cells (CSCs) and other cancer treatment modalities. The company utilizes a unique biotechnology platform to create novel therapeutic products designed to address the complexities of cancer treatment. Through its commitment to advancing cancer therapies, Eclipse Therapeutics seeks to improve patient outcomes and contribute to the ongoing fight against cancer.

Independa, Inc. is a company that develops cloud-based software solutions aimed at enhancing the well-being and social engagement of senior citizens. Its primary offerings include AnyTV Companion, a remote care platform that facilitates social interaction and provides medication reminders, appointment notifications, and monitoring capabilities. The company also offers CloudCare, an enterprise solution that integrates various modules for remote care and community involvement, along with a caregiver dashboard that simplifies monitoring and support for care recipients. Additionally, the Angela solution addresses the challenges faced by seniors wishing to maintain their independence. Independa’s software features smart reminders for events and activities, a broadcast messaging system for alerts and updates, and integrated monitoring to track health and safety. Founded in 2009 and based in San Diego, California, the company serves a range of clients, including senior living communities, hospitals, and home care organizations, and has formed a strategic partnership with LG Electronics to enhance its service offerings.