LivaNova

Noctrix Health, Inc. is an early-stage medical device company based in Menlo Park, California, founded in 2018. The company specializes in the development of therapeutic wearable devices aimed at treating chronic neurological and sleep disorders. By focusing on innovative therapies, Noctrix Health seeks to address the unmet needs of patients suffering from these conditions.

ShiraTronics is in the early stages of developing new innovative therapies to combat debilitating migraine headaches. The company is focused on commercializing novel neuromodulation technologies to treat this large unmet clinical need for patients and physicians. ShiraTronics is the first spinout from NuXcel a global medical device accelerator company.

Ceribell, Inc. specializes in the design and manufacture of medical devices aimed at acquiring and interpreting electroencephalography (EEG) data for patients with neurological conditions. The company offers the Ceribell EEG System, which includes a versatile EEG headband accommodating various hair types and head sizes, and a compact, battery-operated EEG recorder that delivers clinical-quality data with an on-device display. Ceribell focuses on improving the accessibility and efficiency of EEG technology by developing an FDA-cleared instant EEG system that can be set up by any healthcare provider in just six minutes, eliminating the need for specialized technologists. This system features a unique Brain Stethoscope function that converts brainwaves into sound, allowing for the detection of seizures through auditory means. By facilitating earlier diagnoses and targeted treatments for seizures, including non-convulsive seizures, Ceribell aims to enhance patient outcomes while reducing risks such as mortality and complications. Founded in 2014 and based in Mountain View, California, Ceribell is committed to transforming the diagnosis and management of serious neurological conditions in acute care settings.

TandemLife specializes in the development and manufacturing of innovative medical devices designed to assist cardiologists and cardiac surgeons in providing circulatory support for patients experiencing heart failure. The company’s flagship product, the TandemHeart System, is FDA-cleared and allows for rapid extracorporeal circulatory support, operational in minutes rather than hours. This system can deliver varying levels of circulatory support, up to 5.0 liters per minute through percutaneous methods, and up to 8.0 liters per minute using direct surgical cannulation. The TandemHeart System consists of three key components: the TandemHeart Pump, which circulates oxygenated blood; the Cannulae Set, which connects the pump to the patient; and the Controllers, which manage the pump's operation and monitor system performance. By enabling efficient and effective cardiopulmonary bypass procedures, TandemLife aims to enhance patient outcomes while potentially lowering healthcare costs.

ImThera Medical, Inc. is a San Diego-based medical device company focused on developing implantable neurostimulation devices for the treatment of obstructive sleep apnea (OSA). Founded in 2004, the company offers the THN Sleep Therapy System, which includes the aura6000 device. This innovative system delivers mild stimulation to key tongue muscles during sleep, helping to maintain airway openness and significantly reducing or eliminating OSA events. With an estimated 28 million Americans affected by OSA, compliance with traditional CPAP therapy remains a challenge for many patients. ImThera's solution aims to improve patient outcomes and quality of life while potentially lowering healthcare costs associated with OSA complications. As of January 2018, ImThera Medical operates as a subsidiary of LivaNova PLC.

HighLife SAS is a medtech company that specializes in developing a novel transcatheter mitral valve replacement system aimed at treating patients with mitral regurgitation. Founded in 2010 and headquartered in Paris, France, with an additional office in Irvine, California, the company focuses on providing a minimally invasive prosthetic mitral valve that can be implanted on a beating heart. This approach preserves the native valve structure and respects the surrounding anatomy, ensuring reduced trauma during surgical procedures. HighLife's technology is designed for ease and safety of use, as well as optimal treatment outcomes, allowing for delivery through a transseptal passage via the femoral vein. The system is currently undergoing clinical evaluation to assess its effectiveness in addressing severe heart conditions.

Caisson Interventional, LLC, founded in 2012 and located in Maple Grove, Minnesota, is a clinical-stage medical device company specializing in the design and development of a novel percutaneous mitral valve replacement system. The company operates as a subsidiary of LivaNova PLC as of May 2017. Caisson Interventional is engaged in the clinical evaluation of its innovative technology, aimed at improving treatment options for patients with mitral valve disorders.

MD Start SA is a Swiss-based incubator and fund focused on the medical technology sector, established in 2009. The company specializes in transforming innovative medical ideas into viable business ventures, providing comprehensive support from project creation to operational development. It partners with prominent organizations in the industry, including Medtronic and Sofinnova Partners, to facilitate the growth of medical device start-ups. By employing both strategic and hands-on approaches, MD Start aims to guide these projects through the investment stage and into commercial development, helping to bring new medical technologies to market.

Cyberonics is committed to advancing device-based solutions that improve the lives of patients and their families. Their core beliefs guide us to design, develop and market patient-focused medical device solutions for people affected by epilepsy, depression, and other chronic disorders.