National Science Foundation

The National Science Foundation (NSF), established in 1950 and located in Alexandria, Virginia, is an independent federal agency dedicated to advancing fundamental research and education across all scientific and engineering disciplines. With an annual budget of approximately $7.8 billion, the NSF operates America's Seed Fund, which allocates nearly $200 million each year to support startups and small businesses through the Small Business Innovation Research (SBIR) program. This initiative provides non-dilutive funding of up to $1.5 million to assist in research and development efforts, thereby facilitating the transformation of scientific discoveries into commercially viable products and services. By helping to de-risk technology, the NSF plays a crucial role in fostering innovation and addressing societal challenges through scientific advancements.

James Donlon

Program Director

Sean L. Jones

Assistant Director for Mathematical and Physical Sciences

Sethuraman Panchanathan

Director

Ben Schrag Ph.D

Program Director and Policy Liaison, SBIR / STTR

Past deals in Maryland

Virtual Apprentice

Grant in 2022
Virtual Apprentice offers virtual reality workplace and occupational training. They also utilize VR to help with recruitment, upskilling, and employment retention. Their training content enhances productivity in healthcare, construction, communications, technology, transportation, manufacturing, hospitality, and education.

Relavo

Grant in 2022
Relavo, LLC is a medical device company founded in 2018 and based in Baltimore, Maryland. The company focuses on developing solutions to prevent infection related to peritoneal dialysis, specifically through its product, The PeritoneX. This device disinfects contamination points prior to the initiation of dialysis treatment, thereby helping patients with kidney failure to lower their risk of developing peritonitis. By offering an affordable means to enhance safety during peritoneal dialysis, Relavo aims to improve patient outcomes in this critical area of healthcare.

Inception Robotics

Grant in 2022
Inception Robotics offers robot as a service and software as a service. They provide services such as contactless deliveries, safe navigation in dense crowds, robust indoor localization, compliant navigation, robust AI-based navigation, multi-modal sensor configuration support, environment data analysis, cloud-based deployment, and monitoring.

Liatris

Grant in 2022
Developer of insulation products designed to make life affordable, comfortable and safe through the management of thermal energy. The company's product offers performance improvements and can achieve significant energy savings versus building insulation and leading to project paybacks, enabling engineers and the construction sector to reduce costs through low-cost manufacturing and facile installation.

PediaMetrix

Grant in 2022
PediaMetrix Inc. develops a smart digital tool for pediatric head measurement and monitoring. It offers a flat head syndrome app enables parents to receive accurate measures of their baby's head shape and receive repositioning instructions specific to their baby instantly. The company’s app also enables pediatricians to have access to the data and easy-to-understand analysis of the smart algorithms behind the app to save time and ensure quality care. PediaMetrix Inc. was founded in 2018 and is based in Rockville, Maryland.

Pathotrak

Grant in 2022
PathOtrak, LLC specializes in developing food safety testing kits that facilitate the rapid detection of pathogens, such as Salmonella and E. coli, in food products. Founded in 2016 and located in College Park, Maryland, the company employs innovative microfiltration technology in its sample-preparation kits to significantly reduce testing time from days to hours. This advancement not only enhances food safety but also allows producers to release products more quickly, improving the balance between shelf life, profitability, and safety in the food industry. PathOtrak's solutions are validated through extensive testing and analysis, addressing the critical needs of various stakeholders involved in ensuring a safe food supply.

The Wrightguard

Grant in 2021
The Wrightguard specializes in the development of innovative smart mouthguards tailored for athletes. These mouthguards are equipped with advanced sensors and wireless communication technology that gather real-time biometric data, enabling the monitoring of both health and performance. This technology aims to enhance athlete safety by ensuring consistent placement and uniform thickness of shock-absorbing materials, providing effective protection during sports activities. Wrightguard's products offer an affordable dental solution, making it easier for athletes to prioritize their safety while competing.

xMD Diagnostics

Grant in 2021
xMD Diagnostics operates in the healthcare industry focusing on biotechnology business. The company was formerly known as Bay Resources Development Group. The company is headquartered in Annapolis, Maryland. xMD Diagnostics uses high-throughput microdissection technology for the diagnosis of cancer.

Zeteo Tech

Grant in 2021
Zeteo Tech LLC is a defense technology company that focuses on researching, developing, prototyping, and commercializing innovative solutions in the fields of biodefense and medical devices. Founded in 2013 and headquartered in Maryland, the company specializes in creating advanced instrumentation, such as fieldable biological mass spectrometers that can identify airborne microbes, proteins, and lipids. This technology aids in screening for infectious diseases and other biological threats, allowing healthcare professionals to automate detection in operational environments while reducing costs. Additionally, Zeteo Tech's portfolio includes air and water purification systems, portable power solutions, and technologies for CBRNE (Chemical, Biological, Radiological, Nuclear, and Explosives) detection and decontamination. The company serves a diverse clientele, including national security agencies, private enterprises, and government organizations within the United States.

Softhread

Grant in 2021
Softhread is a blockchain technology company that develops enterprise solutions using a blockchain and AI-enabled platform. The company was founded in 2017 and is headquartered in Baltimore, Maryland.

MileMarker

Grant in 2021
MileMarker is a web-based assessment platform designed to enhance medical training through real-time evaluations. Developed by leaders from the Johns Hopkins University School of Medicine, it addresses the challenges of evolving competency requirements in medical education while reducing training costs. The platform enables residents to log operative cases and conduct self-assessments, which are then followed by evaluations from attending surgeons. These assessments can be completed swiftly, integrating seamlessly into the workflow of medical professionals. By capturing real-time data on resident performance, MileMarker allows for continuous monitoring and comparison of individual progress against peers, facilitating a more efficient training process. The software not only improves communication and efficiency within residency programs but also has the potential to significantly increase program revenue and reduce training duration. Accessible on any mobile device or computer, MileMarker positions itself as a vital tool for residency programs aiming to meet regulatory demands and enhance the quality of medical education.

Tethys Research

Grant in 2021
Developer of industrial enzymes intended to provide high value enzymes and chemical entities to businesses. The company develops combination of disparate disciplines to overcome problems that are not amenable to throughput screening methodologies in order to discover new, high value enzymes and chemical entities, enabling organizations to produce and market chemical products and processes through contract or in partnership .

Hermes Life Sciences

Grant in 2021
Hermes Life Sciences develops solutions to improve the accuracy and accessibility of blood testing at the point of care. The company was founded by Sasank Vemulapati.

Minnowtech

Grant in 2021
Minnowtech is an aquaculture technology company based in Baltimore, Maryland, focused on improving shrimp farming through innovative software solutions. The company has developed a non-invasive imaging platform that leverages artificial intelligence and image analysis to accurately estimate shrimp abundance and biomass in ponds. This technology allows shrimp farmers to optimize feeding regimes, enhance harvests, and manage risks associated with juvenile shrimp health. By addressing critical challenges in the aquaculture industry, such as the assessment of shrimp growth and optimal harvest times, Minnowtech aims to improve the livelihoods of farmers while contributing to global food security and the sustainability of marine environments.

OnSystem Logic

Grant in 2021
Developer of security software designed to prevent malware and application vulnerabilities from compromising computer systems. The company's software offers a non-bypassable application hardening ability that works within existing software to protect against cyber threats, enabling businesses to have a preventative layer of defense.

VecTech

Grant in 2021
VecTech specializes in advanced mosquito and tick surveillance through a cloud-connected system of smart traps. These traps capture mosquito specimens, which are then imaged and automatically analyzed using AI-based identification algorithms to classify them by genus and species. Each specimen is tagged with GPS coordinates, and the collected data is displayed on a centralized dashboard for expert review. This innovative approach significantly reduces labor costs associated with traditional surveillance methods, enabling scientists and public health organizations to monitor mosquito populations more effectively. By providing timely and precise data, VecTech supports efforts to combat mosquito-borne diseases such as dengue and malaria, allowing for early detection of potential outbreaks and tailored interventions.

NeuroLogic Solutions

Grant in 2021
NeuroLogic Solutions, established in 2016 and based in Baltimore, Maryland, develops advanced EEG analytic software aimed at enhancing the diagnosis and treatment of epilepsy. The company’s platform analyzes electroencephalography data to identify regions of the brain affected by seizures, which assists clinicians in diagnosing epilepsy more accurately and guiding surgical interventions. By providing insights that can lead to seizure freedom, NeuroLogic Solutions seeks to improve patient outcomes and contribute to the overall effectiveness of epilepsy care.
Precision Theranostics is a biotechnology company based in Baltimore, Maryland, founded in 2019. The company focuses on developing prognosis-based intervention strategies aimed at the early detection and treatment of fatal diseases. Its innovative platform is designed to estimate disease progression, particularly for respiratory diseases and age-related disorders. By creating novel diagnostics, therapeutics, and prognosis-based therapies, Precision Theranostics enables healthcare providers to deliver timely diagnoses and interventions, ultimately improving survival rates and preventing the progression of chronic and fatal conditions.

Ortuvo

Grant in 2021
Ortuvo develops 3D printing research tools for tissue engineering and custom bio-inks for the healthcare and biotech industries. The company was founded in 2020 and is headquartered in Baltimore, Maryland.

BondTrue

Grant in 2021
BondTrue LLC is a medical device company focused on enhancing surgical accuracy through automation. The company's patented device automates the processes of surgical incisions and closures, allowing for rapid approximation and repair of surgical wounds. This innovation enables surgeons to execute clean, consistent incisions and achieve precise suturing. Recently, BondTrue received a Phase II Maryland Industrial Partnerships (MIPS) award from the Maryland Technology Enterprise Institute, which provides funding for research and development in collaboration with universities. The $100,000 grant will support the continued development of the device, following successful completion of Phase I. BondTrue plans to refine its prototype designs, which will undergo further research and testing to advance the commercialization of this medical technology.

PediaMetrix

Seed Round in 2021
PediaMetrix Inc. develops a smart digital tool for pediatric head measurement and monitoring. It offers a flat head syndrome app enables parents to receive accurate measures of their baby's head shape and receive repositioning instructions specific to their baby instantly. The company’s app also enables pediatricians to have access to the data and easy-to-understand analysis of the smart algorithms behind the app to save time and ensure quality care. PediaMetrix Inc. was founded in 2018 and is based in Rockville, Maryland.

Oncospace

Grant in 2021
Oncospace is a medical device manufacturing company that specializes in radiation oncology. It features an AI-based platform that takes advantage of this knowledge to personalize each patient’s treatment, minimize side effects, and maintains the quality of life. The company was founded in 2019 and headquartered in Baltimore, Maryland.

Modular Matter

Grant in 2021
Modular Matter develops a prosthesis system aimed at providing those with limb differences with mobility, strength, comfort, and confidence. The company. was founded by Jeff Gair, who is also the developer of the modular socket.

Lasarrus

Grant in 2020
Lasarrus is a Baltimore-based company founded in 2013 that specializes in developing wearable devices for patients with chronic obstructive pulmonary disease (COPD). The company's innovative device is designed to enhance physical therapy by facilitating telemedicine and remote monitoring. It captures physiological and range-of-motion data, allowing patients to track their health routines effectively. Lasarrus aims to provide an affordable, comfortable, and non-invasive solution that accelerates recovery for users, improving their overall health management.

Cornerstone Genomics

Grant in 2020
Cornerstone Genomics offers advice on the use of genomic tools in human disease and biomedicine, veterinary sciences, and wildlife research. The company was founded in 2017 and is headquartered in Frederick, Maryland.

Relavo

Grant in 2020
Relavo, LLC is a medical device company founded in 2018 and based in Baltimore, Maryland. The company focuses on developing solutions to prevent infection related to peritoneal dialysis, specifically through its product, The PeritoneX. This device disinfects contamination points prior to the initiation of dialysis treatment, thereby helping patients with kidney failure to lower their risk of developing peritonitis. By offering an affordable means to enhance safety during peritoneal dialysis, Relavo aims to improve patient outcomes in this critical area of healthcare.
Digital Harbor Foundation is comprised of people who love what they do and work hard day-in and day-out to make a difference in the lives of the youth they serve. They think hard about education, technology, and innovation, and work even harder to overcome the socio-economic barriers that impede forward progress for too many. They are not perfect but they care about their work and give it everything they have every day.
As part of the University System of Maryland, the University of Maryland – Baltimore County offers the extensive academic resources of a large research university. UMBC emphasizes science and engineering, but the university offers academics in a variety of subjects. UMBC is comprised of the following academic divisions: *College of Arts, Humanities and Social Sciences *College of Engineering and Information Technology *College of Natural and Mathematical Sciences *The Erickson School *Graduate School *School of Social Work More than 40 undergraduate majors are available, as well as nearly 40 master’s and about 25 doctoral degree programs. The university also offers professional development courses in subjects like Business Analysis, English Language Training and Project Management. Student life at University of Maryland Baltimore County has something for everyone. The university participates in NCAA Division I athletics, and the campus is rich with arts and culture, supported by institutes like the Center for Art, Design & Visual Culture. Financial aid at UMBC comes in several forms. In addition to federal grants and loans, students can apply for a variety of institutional scholarships. These awards are based on merit, and many of them are renewable.

Pathotrak

Grant in 2020
PathOtrak, LLC specializes in developing food safety testing kits that facilitate the rapid detection of pathogens, such as Salmonella and E. coli, in food products. Founded in 2016 and located in College Park, Maryland, the company employs innovative microfiltration technology in its sample-preparation kits to significantly reduce testing time from days to hours. This advancement not only enhances food safety but also allows producers to release products more quickly, improving the balance between shelf life, profitability, and safety in the food industry. PathOtrak's solutions are validated through extensive testing and analysis, addressing the critical needs of various stakeholders involved in ensuring a safe food supply.

Emanate Wireless

Grant in 2020
Emanate Wireless builds solutions that continuously monitor the operation and productivity of key clinical assets at healthcare facilities. The management of clinical assets that are constantly moving and/or in use can be chaotic. Optimizing this process is key to enhancing productivity and reducing staff stress.

AmpX Technologies

Grant in 2020
AmpX Technologies, founded in 2018 and based in College Park, Maryland, specializes in developing custom power electronics technology aimed at transforming academic research into commercial applications. The company focuses on creating reliable and cost-effective power electronic products that serve the automotive, industrial, and consumer electronics sectors. Additionally, AmpX Technologies designs energy conversion systems for electric vehicles, emphasizing simpler platforms, reduced costs, enhanced efficiency, and increased robustness. This enables clients to create modular and efficient products tailored to their specific needs.

VerImmune

Grant in 2020
VerImmune, based in Baltimore, Maryland, is an immuno-oncology company focused on developing innovative cancer therapies through a unique approach called Anti-tumor Immune Redirection. The company employs proprietary virus-inspired particles, known as Anti-tumor Immune Redirection Virus-inspired Particles (AIR-ViPs), which harness pre-existing immune memory from past infections or childhood vaccinations to target tumors. This strategy aims to offer a new treatment option for patients with limited alternatives or those who have developed resistance to conventional cancer therapies. VerImmune's technology seeks to deliver low toxicity and sustainable benefits across a wide array of cancers, potentially reshaping the treatment landscape for difficult-to-treat cases.

Gaskiya

Grant in 2020
Gaskiya Diagnostics, founded in 2019 and based in Baltimore, Maryland, specializes in developing paper-based diagnostic test kits for the detection of aquatic diseases. The company employs bioengineered capture proteins to bind to specific disease targets, offering a diagnostic solution that is both cost-effective and easy to use. These tests enable aquaculture farmers to accurately identify and prevent diseases, thereby minimizing potential revenue losses associated with disease outbreaks. Gaskiya's focus on sensitivity and specificity in its diagnostic tools positions it as a valuable partner in the aquaculture industry.

ChameleonCloud

Grant in 2020
Cloud services have become ubiquitous to all major 21st century economic activities. However, cloud services and technologies can be significantly more powerful than they are now. A persistent barrier to further advancement has been the lack of a large-scale and open cloud research platforms. With funding from the National Science Foundation (NSF), the Chameleon project will provide such a large-scale platform to the open research community allowing them explore transformative concepts in deeply programmable cloud services, design, and core technologies. Chameleon will allow users to explore problems ranging from the creation of Software as a Service to kernel support for virtualization. This broad range of supported research includes many other areas such as developing Platforms as a Service, creating new and optimizing existing Infrastructure as a Service components, investigating software-defined networking, and optimizing virtualization technologies. The Chameleon testbed, will be deployed at the University of Chicago and the Texas Advanced Computing Center and will consist of 650 multi-core cloud nodes, 5PB of total disk space, and leverage 100 Gbps connection between the sites. While a large part of the testbed will consist of homogenous hardware to support large-scale experiments, a portion of it will support heterogeneous units allowing experimentation with high-memory, large-disk, low-power, GPU, and co-processor units. The project will also leverage existing FutureGrid hardware at the University of Chicago and the Texas Advanced Computing Center in its first year to provide a transition period for the existing FutureGrid community of experimental users. To support the broad range of experiments experiments described above, the project will support a graduated configuration system allowing full user configurability of the software stack, from provisioning of bare metal and network interconnects to delivery of fully functioning cloud environments. A special feature of Chameleon is that it provides for an exceptionally close integration of clouds and networks, which substantially enhances the capabilities of both. In addition, to facilitate experiments, Chameleon will support a set of services designed to meet researchers needs, including support for experimental management, reproducibility, and repositories of trace and workload data of production cloud workloads. The project is led by the Computation Institute at the University of Chicago and partners from the Texas Advanced Computing Center at the University of Texas at Austin, the International Center for Advanced Internet Research at Northwestern University, the Ohio State University, and University of Texas at San Antonio, comprising a highly qualified and experienced team. The team includes members from the NSF supported FutureGrid project and from the GENI community, both forerunners of the NSFCloud solicitation under which this project is funded. Chameleon will also form a set of partnerships with commercial and academic clouds, such as Rackspace, CERN and Open Science Data Cloud (OSDC), and will partner with other testbeds, notably GENI and INRIA's Grid'5000 testbed.

MedApptic

Grant in 2020
MedApptic develops an electronic drug dispenser system. The company was founded in 2018 and is headquartered in Germantown, Maryland.

3i Diagnostics

Grant in 2020
Operator of a direct-from-blood testing platform designed to identify bloodstream microbes within minutes. The company's platform incorporates a fluidics component that isolates whole pathogens and creates a passage through channels that lyse blood cells, enabling physicians and clinical researchers to eliminate the need to identify bloodstream bacterial disease and get detailed information on all strains of microbes.

Liatris

Grant in 2020
Developer of insulation products designed to make life affordable, comfortable and safe through the management of thermal energy. The company's product offers performance improvements and can achieve significant energy savings versus building insulation and leading to project paybacks, enabling engineers and the construction sector to reduce costs through low-cost manufacturing and facile installation.

Dentuit

Grant in 2020
Excise bias from routine elements of dental examinations by developing consensus-based automation using computer vision. Support payors by automating elements of their claims review process. Empower non-specialists with data-driven triaging to help patients efficiently navigate their provider network. Advance broader access to dental care by mobilizing remote screenings at drugstore kiosks and community health centers.
Multisensor Diagnostics (MDx), LLC, is a diversified health and wellness company primarily serving the high-acuity patients.

CeleFlux

Grant in 2020
CeleFlux, founded in 2019 and located in Severna Park, Maryland, specializes in the development of urological medical devices aimed at reconstructing the urethra to restore urine flow. The company's innovative device serves as a bridge between existing minimally invasive management options and traditional open surgical reconstruction. By focusing on enhancing the treatment of urological conditions, CeleFlux aims to improve the quality of life for patients through effective and less invasive solutions.

Troposphere

Grant in 2020
Troposphere Monitoring Inc., founded in 2018 and headquartered in Baltimore, Maryland, specializes in environmental monitoring by operating air quality control stations. These stations measure critical environmental parameters, including temperature, relative humidity, ozone, and nitrogen dioxide, providing vital data about air quality. The company aims to enhance public awareness of air and water quality through its innovative monitoring solutions. As of December 2020, Troposphere operates as a subsidiary of Project Canary, Inc., and is planning an international expansion of its services beyond its home city.

Malcova

Grant in 2020
Malcova is a medical technology company established in 2019 and based in Baltimore, Maryland. The company specializes in developing medical imaging devices aimed at improving the detection and diagnosis of breast cancer, particularly in women with dense breast tissue. Malcova's devices leverage advancements in CT imaging science, offering advantages over traditional methods such as mammography and tomosynthesis. By integrating innovative techniques in CT image acquisition, Malcova seeks to enhance the effectiveness of breast cancer treatment for physicians and improve patient outcomes.

SeeTrue Technology

Grant in 2020
SeeTrue Technology reduces clogging, cell adherence, tissue damage, tip visibility, and directional targeted injection. They have an injection needle that transforms the biomedical industry. They reduce the adherence of cells to the inner surface of the microneedle.

Neurosonics Medical

Grant in 2020
Neurosonics Medical specializes in ultrasound devices for brain tumor ablation. The company was founded in 2018 and is headquartered in Baltimore, Maryland.

Eyedea Medical

Grant in 2020
Developer of a single-use graft preparation system designed to assist in cornea transplant. The company's system simplifies corneal tissue processing, improving yields and expanding the donor pool while maintaining high-quality grafts for transplants, enabling eye professionals to reduce costs and empower their capacity and efficacy.
SpringGem Weather Information is a weather forecasting platform based in North Potomac, Maryland, founded by Menglin Susan. The company offers current and forecasted weather and energy information as a free community service. Its platform utilizes advanced technologies, including numerical weather forecasting, satellite and ground remote sensing, data science, and cloud computing, to deliver hyperlocal weather information. This service supports various sectors, including urban energy management, traffic safety, agriculture monitoring, and environmental assessment, ensuring that individuals and organizations have access to accurate weather data tailored to their specific needs.

Hermes Life Sciences

Grant in 2019
Hermes Life Sciences develops solutions to improve the accuracy and accessibility of blood testing at the point of care. The company was founded by Sasank Vemulapati.

Airgility

Grant in 2019
Designer and manufacturer of unmanned aerial systems designed to fly anywhere. The company's products are artificially intelligent drones that can fly to confined areas where there is limited or no global positioning system access, enabling clients to get information in real-time and improving decision-making in the critical moments of a disaster or for any type of inspection/assessment.

PediaMetrix

Pre Seed Round in 2019
PediaMetrix Inc. develops a smart digital tool for pediatric head measurement and monitoring. It offers a flat head syndrome app enables parents to receive accurate measures of their baby's head shape and receive repositioning instructions specific to their baby instantly. The company’s app also enables pediatricians to have access to the data and easy-to-understand analysis of the smart algorithms behind the app to save time and ensure quality care. PediaMetrix Inc. was founded in 2018 and is based in Rockville, Maryland.

Lasarrus

Grant in 2019
Lasarrus is a Baltimore-based company founded in 2013 that specializes in developing wearable devices for patients with chronic obstructive pulmonary disease (COPD). The company's innovative device is designed to enhance physical therapy by facilitating telemedicine and remote monitoring. It captures physiological and range-of-motion data, allowing patients to track their health routines effectively. Lasarrus aims to provide an affordable, comfortable, and non-invasive solution that accelerates recovery for users, improving their overall health management.

Oncospace

Grant in 2019
Oncospace is a medical device manufacturing company that specializes in radiation oncology. It features an AI-based platform that takes advantage of this knowledge to personalize each patient’s treatment, minimize side effects, and maintains the quality of life. The company was founded in 2019 and headquartered in Baltimore, Maryland.

Pneumico

Grant in 2019
Pneumico develops respiratory monitoring devices that collect, reveal, and analyze breathing data from patients who require ventilatory assistance. The company was founded in 2017 and is headquartered in Baltimore, Maryland.

Minnowtech

Grant in 2019
Minnowtech is an aquaculture technology company based in Baltimore, Maryland, focused on improving shrimp farming through innovative software solutions. The company has developed a non-invasive imaging platform that leverages artificial intelligence and image analysis to accurately estimate shrimp abundance and biomass in ponds. This technology allows shrimp farmers to optimize feeding regimes, enhance harvests, and manage risks associated with juvenile shrimp health. By addressing critical challenges in the aquaculture industry, such as the assessment of shrimp growth and optimal harvest times, Minnowtech aims to improve the livelihoods of farmers while contributing to global food security and the sustainability of marine environments.

PediaMetrix

Pre Seed Round in 2019
PediaMetrix Inc. develops a smart digital tool for pediatric head measurement and monitoring. It offers a flat head syndrome app enables parents to receive accurate measures of their baby's head shape and receive repositioning instructions specific to their baby instantly. The company’s app also enables pediatricians to have access to the data and easy-to-understand analysis of the smart algorithms behind the app to save time and ensure quality care. PediaMetrix Inc. was founded in 2018 and is based in Rockville, Maryland.

Bluelene

Grant in 2019
Magic Blue is a company develops skin care products using Methylene blue.

Spine Align

Grant in 2019
Spine Align, LLC, founded in 2017 and based in Baltimore, Maryland, is a medical device company focused on advancing spinal surgery through innovative imaging technology. The company is developing a platform that provides real-time, three-dimensional measurements of spinal alignment during corrective spinal fusion surgeries. Its flagship product enhances intraoperative alignment assessments while reducing reliance on X-ray imaging. This approach aims to standardize surgical outcomes and address the challenges of high revision rates associated with primary spine surgeries. Through its patent-pending technology, Spine Align seeks to improve the precision and effectiveness of spinal procedures, benefiting both medical professionals and patients.

AmpX Technologies

Grant in 2019
AmpX Technologies, founded in 2018 and based in College Park, Maryland, specializes in developing custom power electronics technology aimed at transforming academic research into commercial applications. The company focuses on creating reliable and cost-effective power electronic products that serve the automotive, industrial, and consumer electronics sectors. Additionally, AmpX Technologies designs energy conversion systems for electric vehicles, emphasizing simpler platforms, reduced costs, enhanced efficiency, and increased robustness. This enables clients to create modular and efficient products tailored to their specific needs.

Cornerstone Genomics

Grant in 2019
Cornerstone Genomics offers advice on the use of genomic tools in human disease and biomedicine, veterinary sciences, and wildlife research. The company was founded in 2017 and is headquartered in Frederick, Maryland.

ClearMask

Grant in 2018
ClearMask, LLC is a manufacturer of full transparent surgical masks, incorporated in 2017 and headquartered in Baltimore, Maryland. The company's innovative, patent-pending masks provide ASTM Level 3 fluid protection, addressing the need for safety in healthcare settings. By facilitating whole-face communication, ClearMask's products enhance patient interactions, making them more compassionate and inclusive. This design helps to reduce medical errors associated with miscommunication, thus improving patient satisfaction and compliance, particularly for deaf and immunosuppressed individuals. The masks promote better understanding through visibility of facial expressions while ensuring comfort, breathability, and safety for both patients and healthcare providers.

Tanzen Medical

Grant in 2018
Tanzen Medical manufactures clinically accurate wearable devices for assessing and improving sleep at home. The company was established in 2017 and is based in Severna Park, Maryland.
Gemstone Biotherapeutics LLC is a biotechnology company that develops technologies for therapeutic applications in wound care and other chronic diseases. The company focuses in the field of tissue engineering and regenerative medicine. It develops a range of tissue engineering inventions with particular emphasis on vascularization and angiogenesis for health care research and clinical markets. Gemstone Biotherapeutics LLC was founded in 2013 and is based in Baltimore, Maryland.
Cykloburn Technologies LLC develops combustion systems that convert poultry waste to energy. The company was founded in 2017 and is based in Baltimore, Maryland.

3i Diagnostics

Grant in 2018
Operator of a direct-from-blood testing platform designed to identify bloodstream microbes within minutes. The company's platform incorporates a fluidics component that isolates whole pathogens and creates a passage through channels that lyse blood cells, enabling physicians and clinical researchers to eliminate the need to identify bloodstream bacterial disease and get detailed information on all strains of microbes.
The University of Maryland, located in College Park and established in 1856, stands as a leading public research university in the United States. Over the last two decades, it has significantly enhanced its reputation and academic accomplishments, positioning itself to compete on a global scale. The university emphasizes research, entrepreneurship, and innovation, aiming to leverage its strengths and capitalize on opportunities for growth. The executive management team oversees the university's assets, ensuring that it pursues ambitious goals with discipline and a forward-thinking approach. The University of Maryland is committed to fulfilling its potential as a premier institution of higher learning.
Brainchild Technologies develops digital applications that improves parent-infant communication by measuring behavioral data from little ones and integrates it into fun and educational games, and applications on computer or smart devices. The company is based in Atlanta, Georgia.

PathoVax

Grant in 2017
PathoVax LLC is a biotechnology company based in Baltimore, Maryland, founded in 2014. It focuses on the development of RGVax, an innovative vaccine designed to protect against human papillomavirus (HPV). RGVax is notable for being the first low-cost HPV vaccine that targets all clinically relevant types, including all 15 oncogenic strains and additional skin HPV types. This broad-spectrum approach addresses the limitations of existing vaccines, which primarily focus on a limited number of cancer-causing strains and often face low uptake due to incomplete coverage and associated social stigma. Established animal studies have demonstrated the protective efficacy of RGVax, positioning it as a suitable childhood vaccine and offering the potential for significant early market entry in a segment that could see higher acceptance and usage rates.

Accelevir

Grant in 2017
Developer of infectious disease assays with a core expertise for quantitation of low-frequency viral targets intended to detect inactive human immunodeficiency viruses in the blood. The company's technology uses a medical device and diagnostic tool to accurately measure the size of the latent reservoir by quantifying the number of intact viruses, enabling physicians to substantially improve the length and quality of life of critically ill patients in areas of major unmet medical and reservoir measurements for the advancement of HIV-1 cure trials.

Glyscend

Grant in 2017
Glyscend, Inc. is a biotechnology company focused on developing innovative therapies for metabolic diseases, particularly type 2 diabetes. Founded in 2014 and based in Baltimore, Maryland, Glyscend aims to provide a non-invasive treatment option that mimics the metabolic benefits of bariatric surgery without the need for invasive procedures. The company's core technology is an orally ingestible intestinal coating that targets the duodenum, inhibiting key neurohormonal pathways to help regulate glucose levels effectively. This approach not only seeks to improve patient outcomes by addressing diabetes directly but also aims to minimize common side effects associated with traditional treatments, such as weight gain and hypoglycemia. Glyscend is committed to equipping healthcare providers with effective tools for treating diabetes, moving beyond mere management of the disease.

Stocastic

Grant in 2017
StoCastic develops healthcare enterprise software that benefits both patients and healthcare organizations. The company was founded in 2015 and is based in Towson, Maryland.
Highland Light Management develops a dry fracture technique in oil and gas extraction to reduce water use and increase life cycle yield. The company is a Maryland corporation that developed and patented the Dry Fracture Shale System technology for hydrocarbon extraction from shale and other hydrocarbon sources.

Sonavex

Grant in 2017
Sonavex, Inc. is a Baltimore-based company founded in 2013 that specializes in advanced imaging technology for surgical patients. The company's primary focus is on developing an ultrasound-based method to detect anastomotic blood clots, which are critical for patient recovery post-surgery. By providing clinicians with real-time visualization of essential data directly at the point of care, Sonavex aims to enhance clinical decision-making and improve patient outcomes. Their proprietary technology platform allows for the measurement of crucial intravascular flow metrics, enabling the early detection of post-operative clots and contributing to better overall surgical results.

Plant Sensory Systems

Grant in 2017
Plant Sensory Systems specializes in developing biological technologies aimed at enhancing agricultural performance. The company focuses on designing modifications to the metabolic and signaling pathways in bacteria and plants to achieve specific outcomes, such as improved nitrogen use efficiency, stress tolerance, and increased oil production in seeds. Their innovative approaches enable companies to optimize crop health, production, and nutritional value, ultimately contributing to more sustainable agricultural practices. With a team of scientists and innovators, Plant Sensory Systems leverages a natural signaling system to address various challenges in crop management and enhance overall agricultural productivity.

Resensys

Grant in 2017
Resensys specializes in structural health monitoring solutions utilizing its advanced wireless Internet of Things (IoT) sensor technology, known as SenSpot. This technology enables high-performance data acquisition with minimal power consumption, exemplified by its wireless strain gauge sensor, which can capture up to 100 strain samples per second while lasting up to ten years on a single battery. In addition to strain measurement, SenSpot sensors are designed to monitor various structural parameters, including vibration, tilt, inclination, temperature, and humidity. By providing real-time data on these critical metrics, SenSpot sensors offer essential insights for detecting overstrain, metal fatigue, crack formation, and foundation instability, thereby supporting infrastructure systems such as bridges, buildings, and pipelines in maintaining their structural integrity.

Medcura

Venture Round in 2016
Medcura, Inc. specializes in developing advanced hemostatic products for various applications, including surgical, medical, and consumer markets. The company utilizes abundant natural materials to create innovative wound care solutions that effectively manage significant surgical bleeds. Its product range includes brands such as R3, Medcura Flex, LifeFoam, and Surgicura, which provide antibacterial barriers and enhance healing environments. Founded in 2007 and based in Riverdale, Maryland, Medcura was formerly known as gel-e, Inc. and rebranded in December 2019. The company's focus on versatile wound treatment positions it as a valuable resource in both clinical and non-clinical settings.

VoiceVibes

Grant in 2016
VoiceVibes empowers people to be more effective communicators. Our innovative voice analytics technology shows exactly how you can improve your oral communication and make the best impression – every time!

Speak Agent

Grant in 2016
Speak Agent, Inc. is an educational technology company based in Rockville, Maryland, that focuses on enhancing vocabulary instruction for English and Spanish language learners. Founded in 2011, the company offers an audiovisual learning platform that allows educators to create and share customized interactive games and activities tailored to the needs of their students. The platform features a bilingual word bank and multimedia library, enabling users to define custom vocabulary sets and develop online games and lessons in English, Spanish, or a bilingual format. Speak Agent aims to address the academic achievement gap for special populations, particularly English Language Learners (ELLs), by providing tools that facilitate effective teaching of academic vocabulary across various subjects. The company has garnered recognition and awards from educational organizations, reflecting its commitment to improving learning outcomes.

Accelevir

Grant in 2016
Developer of infectious disease assays with a core expertise for quantitation of low-frequency viral targets intended to detect inactive human immunodeficiency viruses in the blood. The company's technology uses a medical device and diagnostic tool to accurately measure the size of the latent reservoir by quantifying the number of intact viruses, enabling physicians to substantially improve the length and quality of life of critically ill patients in areas of major unmet medical and reservoir measurements for the advancement of HIV-1 cure trials.

DiPole Materials

Grant in 2016
DiPole Materials is an electrospinning company that manufactures nanofiber for a range of industry needs.

Tarsier Optics

Grant in 2016
Developer of quantum camera technology designed to provide noise-free high-resolution images. The company's technology offers lightweight lenses that are effective for military vehicles, aircraft, and drones and high-resolution images to create new strategic advantages for military lenses, enabling clients to provide high-resolution long-range images free of the distortion caused by heat haze turbulence.

Stocastic

Grant in 2016
StoCastic develops healthcare enterprise software that benefits both patients and healthcare organizations. The company was founded in 2015 and is based in Towson, Maryland.

VoiceVibes

Grant in 2016
VoiceVibes empowers people to be more effective communicators. Our innovative voice analytics technology shows exactly how you can improve your oral communication and make the best impression – every time!

RedShred

Grant in 2015
RedShred helps government contractors, institutions and universities search, pre-qualify and track their best RFP and grant opportunities in half the time. RedShred automatically searches, analyzes and extracts meaningful insights from thousands of publicly available RFPs and grants each day, returning your best opportunities as a match in real-time, eliminating hours of manual research and frustration to dramatically shorten the go/no-go decision-making process.

Luvozo

Grant in 2015
They create service robots and computer-vision technologies to improve resident safety and satisfaction for the long-term care industry.

Plant Sensory Systems

Grant in 2015
Plant Sensory Systems specializes in developing biological technologies aimed at enhancing agricultural performance. The company focuses on designing modifications to the metabolic and signaling pathways in bacteria and plants to achieve specific outcomes, such as improved nitrogen use efficiency, stress tolerance, and increased oil production in seeds. Their innovative approaches enable companies to optimize crop health, production, and nutritional value, ultimately contributing to more sustainable agricultural practices. With a team of scientists and innovators, Plant Sensory Systems leverages a natural signaling system to address various challenges in crop management and enhance overall agricultural productivity.

CC Biotech

Grant in 2015
CC Biotech develops centrifuge-based technology for biomolecule separation and purification. The company was founded in 2006 and is headquartered in Rockville, Maryland.

SecondWrite

Grant in 2015
SecondWrite LLC specializes in creating automated malware analysis solutions aimed at detecting advanced persistent threats (APTs), targeted attacks, and zero-day evasions. The company's flagship product, the SecondWrite Sandbox, is designed to identify evasive malware, capture indicators of compromise (IOCs), and process various file types while integrating seamlessly with existing security systems. Founded in 2010 and based in College Park, Maryland, SecondWrite serves a diverse clientele that includes network security providers, endpoint security firms, security operations centers (SOCs) at enterprises, managed security service providers (MSSPs), incident response teams, and threat intelligence vendors. The company's technology, developed in collaboration with university partners, employs a patent-pending approach that reveals hidden paths in malware and executes them to ensure comprehensive code coverage.

Glyscend

Grant in 2015
Glyscend, Inc. is a biotechnology company focused on developing innovative therapies for metabolic diseases, particularly type 2 diabetes. Founded in 2014 and based in Baltimore, Maryland, Glyscend aims to provide a non-invasive treatment option that mimics the metabolic benefits of bariatric surgery without the need for invasive procedures. The company's core technology is an orally ingestible intestinal coating that targets the duodenum, inhibiting key neurohormonal pathways to help regulate glucose levels effectively. This approach not only seeks to improve patient outcomes by addressing diabetes directly but also aims to minimize common side effects associated with traditional treatments, such as weight gain and hypoglycemia. Glyscend is committed to equipping healthcare providers with effective tools for treating diabetes, moving beyond mere management of the disease.

MycoMed Technologies

Grant in 2015
MycoMed Technologies is focused on the development and commercialization of products to enable early detection and prevention of fungal infections in patients who receive organ transplants, cancer therapy, or immunosuppressant medications.

Clearton

Grant in 2015
Clearton is a technology company that advances human augmentation through automation. The company was founded in 2011 and is headquartered in Rockville, Maryland.

Resensys

Grant in 2015
Resensys specializes in structural health monitoring solutions utilizing its advanced wireless Internet of Things (IoT) sensor technology, known as SenSpot. This technology enables high-performance data acquisition with minimal power consumption, exemplified by its wireless strain gauge sensor, which can capture up to 100 strain samples per second while lasting up to ten years on a single battery. In addition to strain measurement, SenSpot sensors are designed to monitor various structural parameters, including vibration, tilt, inclination, temperature, and humidity. By providing real-time data on these critical metrics, SenSpot sensors offer essential insights for detecting overstrain, metal fatigue, crack formation, and foundation instability, thereby supporting infrastructure systems such as bridges, buildings, and pipelines in maintaining their structural integrity.

VoiceVibes

Grant in 2015
VoiceVibes empowers people to be more effective communicators. Our innovative voice analytics technology shows exactly how you can improve your oral communication and make the best impression – every time!

Speak Agent

Grant in 2015
Speak Agent, Inc. is an educational technology company based in Rockville, Maryland, that focuses on enhancing vocabulary instruction for English and Spanish language learners. Founded in 2011, the company offers an audiovisual learning platform that allows educators to create and share customized interactive games and activities tailored to the needs of their students. The platform features a bilingual word bank and multimedia library, enabling users to define custom vocabulary sets and develop online games and lessons in English, Spanish, or a bilingual format. Speak Agent aims to address the academic achievement gap for special populations, particularly English Language Learners (ELLs), by providing tools that facilitate effective teaching of academic vocabulary across various subjects. The company has garnered recognition and awards from educational organizations, reflecting its commitment to improving learning outcomes.
Weinberg Medical Physics is a small business focused on the development of medical devices for imaging and image-guided therapy, with a particular emphasis on breast cancer detection. The company specializes in creating advanced imaging systems that utilize nanotechnology, specifically employing a shape-engineered iron-based microscopic contrast agent for magnetic resonance imaging. This innovative approach enhances diagnostic accuracy and provides critical clinical indications for detecting breast cancer and guiding surgical interventions. Additionally, Weinberg Medical Physics aims to reduce side effects associated with traditional imaging techniques while enabling researchers to better track stem cells, thereby contributing to advancements in cancer treatment and management.

VisiSonics

Grant in 2014
VisiSonics Corporation develops, markets, and sells products and solutions in 3D sound capture, analysis, and reproduction. The company offers RealSpace, a panoramic audio camera system to capture, understand, and reproduce sound scenes using a combined spherical microphone and camera array; VisiSonics, a digital array microphone to perform digitization; VisiSonics RealSpace 3D Sound, a spatial audio over headphones; and software development kits and modules. Its solutions are used in industrial acoustic analytics, architectural acoustics, acoustic research, audio surveillance, security and surveillance, teleconferencing, telepresence and 3D audio visual virtual reality, and HRTF based 3D sound reproduction applications. The company was founded in 2010 and is based in College Park, Maryland.

SecondWrite

Grant in 2014
SecondWrite LLC specializes in creating automated malware analysis solutions aimed at detecting advanced persistent threats (APTs), targeted attacks, and zero-day evasions. The company's flagship product, the SecondWrite Sandbox, is designed to identify evasive malware, capture indicators of compromise (IOCs), and process various file types while integrating seamlessly with existing security systems. Founded in 2010 and based in College Park, Maryland, SecondWrite serves a diverse clientele that includes network security providers, endpoint security firms, security operations centers (SOCs) at enterprises, managed security service providers (MSSPs), incident response teams, and threat intelligence vendors. The company's technology, developed in collaboration with university partners, employs a patent-pending approach that reveals hidden paths in malware and executes them to ensure comprehensive code coverage.
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