National Science Foundation

The National Science Foundation (NSF), established in 1950 and located in Alexandria, Virginia, is an independent federal agency dedicated to advancing fundamental research and education across all scientific and engineering disciplines. With an annual budget of approximately $7.8 billion, the NSF operates America's Seed Fund, which allocates nearly $200 million each year to support startups and small businesses through the Small Business Innovation Research (SBIR) program. This initiative provides non-dilutive funding of up to $1.5 million to assist in research and development efforts, thereby facilitating the transformation of scientific discoveries into commercially viable products and services. By helping to de-risk technology, the NSF plays a crucial role in fostering innovation and addressing societal challenges through scientific advancements.

James Donlon

Program Director

Sean L. Jones

Assistant Director for Mathematical and Physical Sciences

Sethuraman Panchanathan

Director

Ben Schrag Ph.D

Program Director and Policy Liaison, SBIR / STTR

Past deals in Missouri

Makefully

Grant in 2021
Makefully is a media company committed to creating meaningful, purposeful, and influential learning environments and educational media. The company's headquarters are in Kansas City, Missouri.

Accelerate Wind

Grant in 2021
Accelerate Wind provides wind energy generation for the commercial and industrial spaces. The company develops patent-pending powertrain concept that reduces the cost of wind turbine power electronics through intermediate energy storage in a small flywheel.

Radiologics

Grant in 2020
Developer of clinical trial software designed to provide image data management for clinical trials. The company's platform provides file transfer and verification, integration with clinical data, automation of image processing routines and connectivity, helping health professionals with clinical research and diagnostics.

ChameleonCloud

Grant in 2020
Cloud services have become ubiquitous to all major 21st century economic activities. However, cloud services and technologies can be significantly more powerful than they are now. A persistent barrier to further advancement has been the lack of a large-scale and open cloud research platforms. With funding from the National Science Foundation (NSF), the Chameleon project will provide such a large-scale platform to the open research community allowing them explore transformative concepts in deeply programmable cloud services, design, and core technologies. Chameleon will allow users to explore problems ranging from the creation of Software as a Service to kernel support for virtualization. This broad range of supported research includes many other areas such as developing Platforms as a Service, creating new and optimizing existing Infrastructure as a Service components, investigating software-defined networking, and optimizing virtualization technologies. The Chameleon testbed, will be deployed at the University of Chicago and the Texas Advanced Computing Center and will consist of 650 multi-core cloud nodes, 5PB of total disk space, and leverage 100 Gbps connection between the sites. While a large part of the testbed will consist of homogenous hardware to support large-scale experiments, a portion of it will support heterogeneous units allowing experimentation with high-memory, large-disk, low-power, GPU, and co-processor units. The project will also leverage existing FutureGrid hardware at the University of Chicago and the Texas Advanced Computing Center in its first year to provide a transition period for the existing FutureGrid community of experimental users. To support the broad range of experiments experiments described above, the project will support a graduated configuration system allowing full user configurability of the software stack, from provisioning of bare metal and network interconnects to delivery of fully functioning cloud environments. A special feature of Chameleon is that it provides for an exceptionally close integration of clouds and networks, which substantially enhances the capabilities of both. In addition, to facilitate experiments, Chameleon will support a set of services designed to meet researchers needs, including support for experimental management, reproducibility, and repositories of trace and workload data of production cloud workloads. The project is led by the Computation Institute at the University of Chicago and partners from the Texas Advanced Computing Center at the University of Texas at Austin, the International Center for Advanced Internet Research at Northwestern University, the Ohio State University, and University of Texas at San Antonio, comprising a highly qualified and experienced team. The team includes members from the NSF supported FutureGrid project and from the GENI community, both forerunners of the NSFCloud solicitation under which this project is funded. Chameleon will also form a set of partnerships with commercial and academic clouds, such as Rackspace, CERN and Open Science Data Cloud (OSDC), and will partner with other testbeds, notably GENI and INRIA's Grid'5000 testbed.

Plastomics

Grant in 2020
Plastomics Inc. is a biotechnology company based in Saint Louis, Missouri, that specializes in chloroplast genetic engineering to enhance crop performance. Founded in 2016, the company focuses on developing advanced crops through gene stacking and rapid breeding techniques, aimed at improving yield production and nutritional quality. Plastomics' technology platform allows for the precise insertion of beneficial traits into the chloroplasts of plant cells, which helps seed companies create more effective biotech crops. This innovative approach not only eliminates cross-pollination but also enables unique maternal inheritance, thereby reducing both breeding timelines and costs associated with bringing new products to market. Through its efforts, Plastomics addresses various challenges faced by the agricultural industry.

Infecho Scientific

Grant in 2020
Infecho Scientific specializes in instrumentation research and development. The company was founded in May 2017 and is headquartered in Columbia, Missouri.

MathBRIX

Grant in 2019
MathBRIX is a for-profit EdTech business, with initial support from the National Science Foundation Small Business Research Program (NSF/SBIR). The venture is developing a SaaS math program for children 3-8, which emphasizes higher-order thinking skills and concept acquisition. Children are guided through visual puzzles and games designed to help them see the big ideas behind math, rather than memorize facts. Virtual toy building bricks take the place of traditional manipulatives, with studs on the surface representing numeric value. The platform adjusts to each child's level and comes with a suite of analytics that track learning outcomes. Off computer hands-on projects further extend learning. The MathBRIX mission is to create new learning technologies that will make a significant social and economic impact over time. For the US to remain a world economic leader, all children must be able to think mathematically and problem-solve. Children behind in kindergarten, often stay behind through the remaining school years. Only 40% of U.S. fourth grade students are deemed proficient on national math assessments. Early intervention is key. The visual strategies are derived from the federally-funded Comprehensive School Mathematics Program. Twenty years of research found CSMP students had greater ability to solve novel math problems. CSMP was effective with the gifted as well as the learning challenged. MathBRIX testing with over 500 students confirms high student engagement, feasibility, promise of learning. A larger test is underway in 34 districts nation-wide. In 2018, pre-school and parent education components will be developed with the Parents as Teachers National Center.

ZAF Energy Systems

Grant in 2019
ZAF Energy Systems, Inc. is a battery technology company based in Joplin, Missouri, founded in 2011. The company specializes in the development and commercialization of rechargeable batteries, specifically nickel zinc and zinc air batteries. These products are designed for a wide range of applications, including home and commercial backup storage, renewable energy systems, mobile communication networks, consumer electronics, electric vehicles, and recreational vehicles. ZAF Energy Systems focuses on creating high-performance batteries that are safe, environmentally friendly, and cost-effective, offering significant advantages such as longer run times and improved energy density. By enabling the next generation of electrical devices and enhancing the capabilities of electric vehicles and renewable energy systems, the company aims to contribute to advancements in energy efficiency and sustainability.
Harris-Stowe State University (HSSU), established in 1857, is located in Saint Louis, Missouri, and serves the higher education needs of the metropolitan area. As a historically Black college and university (HBCU), HSSU offers over a dozen bachelor’s degree programs across various fields, including Biology, Education, Professional Interdisciplinary Studies, and Urban Studies. The Anheuser-Busch School of Business is a notable component of the university, providing specialized bachelor’s degrees in business disciplines. Since the introduction of state-of-the-art residence halls in 2006, student life has significantly improved. HSSU is committed to supporting students through its Office of Financial Assistance, which provides information on various financial aid options, including grants, scholarships, and loans. Admission requirements for undergraduate programs include a high school diploma or GED, completion of Missouri’s core high school curriculum, and submission of application materials such as transcripts and nationalized test scores, as applicable.

Accelerate Wind

Grant in 2019
Accelerate Wind provides wind energy generation for the commercial and industrial spaces. The company develops patent-pending powertrain concept that reduces the cost of wind turbine power electronics through intermediate energy storage in a small flywheel.

Makefully

Grant in 2019
Makefully is a media company committed to creating meaningful, purposeful, and influential learning environments and educational media. The company's headquarters are in Kansas City, Missouri.

PatientsVoices

Grant in 2018
PatientsVoices, LLC, founded in 2013 and based in Parkville, Missouri, operates a data analytics platform that transforms patient feedback into actionable insights. This feedback is sourced from survey comments, social media posts, and complaints, allowing the platform to automatically categorize responses based on improvement priorities from the patient's perspective. The company has engaged experts in computing and linguistics to develop its technology, which is currently being tested in hospitals. The platform aims to assist hospital administrators in enhancing patient satisfaction by providing clear, data-driven recommendations for improvement.

PatientsVoices

Seed Round in 2018
PatientsVoices, LLC, founded in 2013 and based in Parkville, Missouri, operates a data analytics platform that transforms patient feedback into actionable insights. This feedback is sourced from survey comments, social media posts, and complaints, allowing the platform to automatically categorize responses based on improvement priorities from the patient's perspective. The company has engaged experts in computing and linguistics to develop its technology, which is currently being tested in hospitals. The platform aims to assist hospital administrators in enhancing patient satisfaction by providing clear, data-driven recommendations for improvement.

Aware Vehicles

Grant in 2018
Aware Vehicles develops self-driving drones that capture and analyze spectral aerial images. The company was founded in 2017 and is headquartered in Kansas City, Missouri.

Nanopore Diagnostics

Grant in 2018
Nanopore Diagnostics, LLC specializes in the development of rapid and portable diagnostic products aimed at identifying bacterial infections. The company's flagship product, the iNDxer, is a nanopore sensor designed to count low concentrations of nucleic acid biomarkers in minimally processed samples. This technology allows for the detection of RNA markers specific to pathogenic bacteria, enabling healthcare providers to make informed antibiotic decisions while reducing unnecessary healthcare costs. By facilitating microbiology lab-quality testing at the point of care, Nanopore Diagnostics ensures that physicians have accurate information about the infections they are treating. Founded in 2011 and located in St. Louis, Missouri, the company focuses on enhancing diagnostic capabilities in clinical settings.

Plasmonic Diagnostics

Grant in 2018
Operator of a biotech company intended to provide a diagnostic system for infectious, sexually transmitted diseases and cancer. The company's platform owns an advanced single molecule detection technology and works on the development of non-invasive and ultra-sensing devices and instruments with a specific focus on biomarkers, enabling patients to take diagnostic tests at affordable costs.

InnoCit

Grant in 2017
InnoCit is a technology transfer and product development company that specializes in power electronic converter development. The company was founded in 2014 and is headquartered in Saint James, Missouri.

Arch Innotek

Grant in 2017
Arch Innotek, LLC is a biotechnology company based in St. Louis, Missouri, that specializes in engineering microorganisms to produce natural ingredients aimed at enhancing human and animal health. Founded in 2013, the company focuses on developing high-value molecules through sustainable fermentation processes, particularly natural carotenoid antioxidants derived from yeast. Arch Innotek's offerings cater to various industries, including food, feed, pharmaceuticals, and cosmetics. In addition to ingredient production, the company provides a range of laboratory services, such as HPLC analysis, LC-MS analysis, protein purification, fermentation strain optimization, and vector construction for protein expression and molecular cloning. Through its innovative technologies, Arch Innotek aims to deliver affordable and sustainable natural nutrition alternatives for consumers.

PixelEXX Systems

Grant in 2017
PixelEXX Systems Inc. develops prototype imaging devices for diagnosing cancer. The products include nanoarrays that take images of molecular signals associated with cellular activity. PixelEXX Systems Inc. was founded in 2008 and is based in Saint Louis, Missouri.

ThermoFlow Labs

Grant in 2016
ThermoFlow Labs specializes in providing high performance and transforming capable technologies into solutions that meet the unique needs of their customers. The company is expected to grow into a competent research institute and manufacturer of insulation products.

GlucanBio

Grant in 2016
GlucanBio is a developer of innovative biomass conversion technology that focuses on producing furan derivatives such as furfural, HMF, DMF, THF, and FDCA. Originating from research at the University of Wisconsin and the Center for Biorenewable Chemicals at Iowa State, the company's processes fractionize biomass under mild conditions, resulting in cost-effective production of specialty and commodity chemicals. This approach not only enhances performance but also supports clients in transitioning toward sustainable practices. With a team that includes experts in catalysis and early-stage commercialization, GlucanBio is well-equipped to address technical challenges in the industry and capitalize on strong market opportunities.
University of Missouri (also known as Mizzou) in Columbia, Missouri, is one of the oldest public universities in the region. Today Mizzou has grown to offer more than 280 degree programs at the undergraduate and graduate levels, including those in medicine and other advanced professional fields. As a full-fledged university with much in the way of academics, research and college life offerings, Mizzou’s more than 30,000 students come from all over the country. Some of the more popular programs at the school include Journalism and Writing. Mizzou is also one of a small group of universities that offers Medicine, Law and Veterinary Medicine. Additional divisions include: *Agriculture *Arts and Sciences *Business *Education *Engineering *Nursing More than 600 student organizations also make their home at Mizzou, so that whatever a student’s interest is it can be found at Mizzou. In order to maintain itself as the competitive public university that it is, Mizzou has had to maintain fairly selective standards for admission. A great number of admitted students were valedictorians of their class or graduated in the top 10%. Mizzou considers grade point average, rigor of high school courses, SAT or ACT scores and other factors such as extracurricular involvement in its undergraduate admissions process. Graduate programs have individual requirements that may include course pre-requisites, undergraduate GPA and test scores. Students may be considered for academic merit scholarships awarded by the school. There are also federal aid sources such as Pell grants, loans and work-study to help those with a financial need to cover tuition costs. Veteran’s benefits are also offered.
Applied Particle Technology. Inc. develops sensors to detect the air quality. It offers air treatment systems in environments that require high efficiency removal of tiny particles. The company’s system operates without a media filter; and inactivates pathogens and remove toxic fumes/odors. It serves construction, industrial hygiene, mining, smart city, manufacturing, and healthcare and research industries. Applied Particle Technology. Inc. was incorporated in 2014 and is headquartered in St. Louis, Missouri.

GlucanBio

Grant in 2015
GlucanBio is a developer of innovative biomass conversion technology that focuses on producing furan derivatives such as furfural, HMF, DMF, THF, and FDCA. Originating from research at the University of Wisconsin and the Center for Biorenewable Chemicals at Iowa State, the company's processes fractionize biomass under mild conditions, resulting in cost-effective production of specialty and commodity chemicals. This approach not only enhances performance but also supports clients in transitioning toward sustainable practices. With a team that includes experts in catalysis and early-stage commercialization, GlucanBio is well-equipped to address technical challenges in the industry and capitalize on strong market opportunities.

PixelEXX Systems

Grant in 2014
PixelEXX Systems Inc. develops prototype imaging devices for diagnosing cancer. The products include nanoarrays that take images of molecular signals associated with cellular activity. PixelEXX Systems Inc. was founded in 2008 and is based in Saint Louis, Missouri.

PatientsVoices

Grant in 2014
PatientsVoices, LLC, founded in 2013 and based in Parkville, Missouri, operates a data analytics platform that transforms patient feedback into actionable insights. This feedback is sourced from survey comments, social media posts, and complaints, allowing the platform to automatically categorize responses based on improvement priorities from the patient's perspective. The company has engaged experts in computing and linguistics to develop its technology, which is currently being tested in hospitals. The platform aims to assist hospital administrators in enhancing patient satisfaction by providing clear, data-driven recommendations for improvement.

Observable Networks

Grant in 2014
Observable offers Network Security-as-a-Service providing automated security analytics and modeling to continuously analyze the behavior of all network devices. Observable Networks, the Clayton-based network security startup.
Townsend Communications engages in two distinct markets for higher education marketing and visual and cinematic arts. They provide quality content and services to local communities.

Benson Hill

Grant in 2013
Benson Hill is an agricultural technology company focused on crop improvement, particularly in soy protein innovation. By leveraging its proprietary CropOS™ platform, the company integrates machine learning, genomic data, and traditional breeding techniques to streamline the development of healthier and more sustainable food products. Benson Hill emphasizes unlocking the natural genetic diversity of plants to empower innovators in creating flavorful and nutritious ingredients. The company operates a Crop Accelerator for rapid prototyping and is developing a diverse seed portfolio that includes protein ingredients, aquaculture, specialty animal feed, and vegetable oils. Its revenue is generated from both proprietary and non-proprietary product categories, reflecting its commitment to advancing agricultural innovation.
Product Innovation and Engineering, LLC (or PINE) was founded in late 2002 as an advanced manufacturing system solution provider. Their main focus has been on software and consulting services in 3-D Rapid Prototyping and 3-D Rapid Manufacturing. PINE's mission is to leverage the engineering and science talents to be a leading 3-D Rapid Manufacturing solution provider. They provide solutions and value for customers through creative engineering and cutting edge technologies.

Benson Hill

Grant in 2013
Benson Hill is an agricultural technology company focused on crop improvement, particularly in soy protein innovation. By leveraging its proprietary CropOS™ platform, the company integrates machine learning, genomic data, and traditional breeding techniques to streamline the development of healthier and more sustainable food products. Benson Hill emphasizes unlocking the natural genetic diversity of plants to empower innovators in creating flavorful and nutritious ingredients. The company operates a Crop Accelerator for rapid prototyping and is developing a diverse seed portfolio that includes protein ingredients, aquaculture, specialty animal feed, and vegetable oils. Its revenue is generated from both proprietary and non-proprietary product categories, reflecting its commitment to advancing agricultural innovation.

OpenCell Technologies

Grant in 2013
OpenCell Technologies, Inc. specializes in providing transfection tools for the life science industry. Founded in 2008 and headquartered in Saint Louis, Missouri, the company offers an intracellular delivery platform designed to facilitate the use of challenging cell types, such as primary and cancer stem cell cultures. These tools support researchers in developing cell-based analysis techniques and discovering new therapeutic cell-based therapies. OpenCell Technologies is committed to enhancing the efficiency and scalability of transfection processes for researchers in the life sciences.

Observable Networks

Grant in 2012
Observable offers Network Security-as-a-Service providing automated security analytics and modeling to continuously analyze the behavior of all network devices. Observable Networks, the Clayton-based network security startup.
Townsend Communications engages in two distinct markets for higher education marketing and visual and cinematic arts. They provide quality content and services to local communities.

PixelEXX Systems

Grant in 2012
PixelEXX Systems Inc. develops prototype imaging devices for diagnosing cancer. The products include nanoarrays that take images of molecular signals associated with cellular activity. PixelEXX Systems Inc. was founded in 2008 and is based in Saint Louis, Missouri.

MOgene

Grant in 2012
MOgene LC, a Limited Liability Company has been in operations since February 2004. The company has established solid reputation as a genomics service provider to academic, government and industrial research groups and institutions. Several papers have been published in leading scientific journals, based on the genomic services provided by MOgene. Company’s management and employees have a vast range of expertise and experience.

QM Power

Grant in 2012
QM Power, Inc. designs and manufactures magnetic circuits and electronic controllers for electric motors, generators, and actuators, serving both domestic and international markets. Founded in 2006 and based in Kansas City, Missouri, the company specializes in products such as synchronous motors, electronic start motors, and fan motors, which are utilized in various applications including commercial refrigeration and HVAC systems. QM Power leverages proprietary technologies, including QSync and Parallel Path Magnetic Technology, to enhance the efficiency and performance of its products. The company has acquired intellectual property from previously owned entities and continues to innovate in collaboration with academic and commercial partners. In addition to its product offerings, QM Power provides financing and services programs to support its customers.

Divergence

Grant in 2009
Divergence is a research and development company dedicated to the discovery of effective and ecologically sound strategies for the control of parasites and other pests. The Company's initial focus is on parasitic nematodes, one of the world's major pest groups. Nematodes are roundworms that cause billions of dollars in damage annually to numerous crops, including soybeans, corn, cotton, strawberries, and bananas. Nematodes causing important human diseases include hookworm, whipworm, roundworm (Ascaris), and the filarial worms responsible for lymphatic filariasis and onchocerciasis.

Divergence

Grant in 2002
Divergence is a research and development company dedicated to the discovery of effective and ecologically sound strategies for the control of parasites and other pests. The Company's initial focus is on parasitic nematodes, one of the world's major pest groups. Nematodes are roundworms that cause billions of dollars in damage annually to numerous crops, including soybeans, corn, cotton, strawberries, and bananas. Nematodes causing important human diseases include hookworm, whipworm, roundworm (Ascaris), and the filarial worms responsible for lymphatic filariasis and onchocerciasis.
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