National Science Foundation

The National Science Foundation (NSF), established in 1950 and located in Alexandria, Virginia, is an independent federal agency dedicated to advancing fundamental research and education across all scientific and engineering disciplines. With an annual budget of approximately $7.8 billion, the NSF operates America's Seed Fund, which allocates nearly $200 million each year to support startups and small businesses through the Small Business Innovation Research (SBIR) program. This initiative provides non-dilutive funding of up to $1.5 million to assist in research and development efforts, thereby facilitating the transformation of scientific discoveries into commercially viable products and services. By helping to de-risk technology, the NSF plays a crucial role in fostering innovation and addressing societal challenges through scientific advancements.

James Donlon

Program Director

Sean L. Jones

Assistant Director for Mathematical and Physical Sciences

Sethuraman Panchanathan

Director

Ben Schrag Ph.D

Program Director and Policy Liaison, SBIR / STTR

Past deals in Wisconsin

WiSys Technology Foundation works hand in hand with the University of Wisconsin System to support research and technology development, link campus innovators with industry leaders and speed technology transfer through patent and licensing activities.

The Water Council

Grant in 2023
The Water Council is focused on redefining the Milwaukee region as the World Water Hub for water research, economic development, and education. It links together global water technology companies, innovative water entrepreneurs, acclaimed academic research programs, and other related professionals.
University of Wisconsin Oshkosh provides students with state-wide resources and ensures academic quality and accountability. UW Oshkosh is committed to providing students with a broad knowledge base and transferable skills as well as a strong sense of values and ethics that prepares them for civic leadership in society. UW Oshkosh is part of the robust University of Wisconsin System—one of the largest systems of public higher education in the country. It was founded in 1871 and its headquarters is located in Oshkosh, Wisconsin.

Augray

Grant in 2022
Augray aims to augment the real and virtual world with fun, educational and timely insights. Augray also works towards facilitating modern and trendy advertising campaigns for brand's products and services. Brands can target their customers through this next generation XR platform (Augmented, Virtual & Mixed Reality) and reap the benefits of high-level user interaction and engagement. How does it work? • To begin with, look for Augray enabled images, advertisements, banners, catalogs, posters etc. • Secondly, open the app and focus on the target object for auto scan. • Now, you're all set to enjoy the powerful and enriched experience of AR World.

ChloBis Water

Grant in 2021
ChloBis Water specializes in innovative electrochemical technologies, specifically the development of a desalination battery. This technology integrates energy storage with the removal of sodium and chlorine from saltwater. The battery is constructed using bismuth as a chloride-storage electrode and sodium as a sodium-storage electrode, allowing it to efficiently desalinate water while simultaneously storing and releasing energy through the manipulation of salt ions. By addressing the challenges at the intersection of water and energy, ChloBis Water offers a solution that enhances energy efficiency and contributes to sustainable water management.
Rapid Radicals Technology specializes in advanced wastewater treatment solutions aimed at helping municipal sewerage districts manage combined sewer overflows. Founded in 2016 and based in Milwaukee, Wisconsin, the company has developed a decentralized, high-rate treatment technology that integrates rapid solids removal with a proprietary advanced oxidation process. This fully automated system is versatile, catering to various applications, including municipal wastewater treatment, industrial high-strength waste management, and emergency scenarios requiring mobile or compact solutions. By providing reliable and cost-effective wastewater management options, Rapid Radicals Technology supports clients in fostering a more resilient water infrastructure.

Pyran

Grant in 2021
Pyran LLC specializes in developing a starting compound for the production of paints and plastic chemicals. Founded in 2017 and based in Madison, Wisconsin, the company creates a diol product derived from renewable wood and crop waste resources. This diol serves as a raw material for various applications, including digital versatile discs, paints, bottles, coatings, plastics, ropes, glues, and adhesives. Pyran primarily caters to the chemical industries, focusing on sustainable solutions for paint and plastic manufacturing.

AgraFilms

Grant in 2021
AgraFilms is a biotechnology company founded in 2019 and based in Madison, Wisconsin, focused on providing sustainable solutions to mitigate crop loss. The company specializes in biocontrol methods, utilizing an amoebic biocontrol approach to address environmental and health challenges associated with synthetic antibiotics and pesticides. By offering natural treatments, AgraFilms aims to empower farmers with effective technology to prevent agricultural diseases and control crop damage, thereby enhancing overall crop health and productivity.

VasoGnosis

Grant in 2020
VasoGnosis is an AI-powered diagnostic and surgical planning software platform for cerebrovascular diseases such as a brain aneurysm. It specializes in the fields of healthcare, machine learning, and software. It was founded in 2019 and headquartered in Milwaukee, Wisconsin.

ChameleonCloud

Grant in 2020
Cloud services have become ubiquitous to all major 21st century economic activities. However, cloud services and technologies can be significantly more powerful than they are now. A persistent barrier to further advancement has been the lack of a large-scale and open cloud research platforms. With funding from the National Science Foundation (NSF), the Chameleon project will provide such a large-scale platform to the open research community allowing them explore transformative concepts in deeply programmable cloud services, design, and core technologies. Chameleon will allow users to explore problems ranging from the creation of Software as a Service to kernel support for virtualization. This broad range of supported research includes many other areas such as developing Platforms as a Service, creating new and optimizing existing Infrastructure as a Service components, investigating software-defined networking, and optimizing virtualization technologies. The Chameleon testbed, will be deployed at the University of Chicago and the Texas Advanced Computing Center and will consist of 650 multi-core cloud nodes, 5PB of total disk space, and leverage 100 Gbps connection between the sites. While a large part of the testbed will consist of homogenous hardware to support large-scale experiments, a portion of it will support heterogeneous units allowing experimentation with high-memory, large-disk, low-power, GPU, and co-processor units. The project will also leverage existing FutureGrid hardware at the University of Chicago and the Texas Advanced Computing Center in its first year to provide a transition period for the existing FutureGrid community of experimental users. To support the broad range of experiments experiments described above, the project will support a graduated configuration system allowing full user configurability of the software stack, from provisioning of bare metal and network interconnects to delivery of fully functioning cloud environments. A special feature of Chameleon is that it provides for an exceptionally close integration of clouds and networks, which substantially enhances the capabilities of both. In addition, to facilitate experiments, Chameleon will support a set of services designed to meet researchers needs, including support for experimental management, reproducibility, and repositories of trace and workload data of production cloud workloads. The project is led by the Computation Institute at the University of Chicago and partners from the Texas Advanced Computing Center at the University of Texas at Austin, the International Center for Advanced Internet Research at Northwestern University, the Ohio State University, and University of Texas at San Antonio, comprising a highly qualified and experienced team. The team includes members from the NSF supported FutureGrid project and from the GENI community, both forerunners of the NSFCloud solicitation under which this project is funded. Chameleon will also form a set of partnerships with commercial and academic clouds, such as Rackspace, CERN and Open Science Data Cloud (OSDC), and will partner with other testbeds, notably GENI and INRIA's Grid'5000 testbed.
Cellulose Sciences International develops novel methods for utilizing celluloses and lignocellulosic. The headquarters of the company are in Madison, Wisconsin.

PhylloTech

Grant in 2020
PhylloTech is focused on producing proteins and antibodies through a continuous plant expression system utilizing glandular secreting trichomes of Nicotiana tabacum. This innovative approach enables the production of difficult-to-manufacture proteins in a cost-effective manner. The system allows proteins to be secreted onto leaf surfaces, where they can be easily recovered with an extraction buffer, eliminating the need for time-consuming purification processes. This method not only reduces production costs but also facilitates rapid scalability, allowing for the cultivation of tens of thousands of plants. PhylloTech's environmentally-friendly system relies on basic inputs like light, water, and fertilizer, making it suitable for efficient growth in greenhouses or fields using existing agricultural practices. Additionally, the company aims to address plant disease challenges and enhance crop yields by employing enzymes to control bacterial pathogens, thereby reducing reliance on synthetic pesticides and microbial biocontrols.
Rapid Radicals Technology specializes in advanced wastewater treatment solutions aimed at helping municipal sewerage districts manage combined sewer overflows. Founded in 2016 and based in Milwaukee, Wisconsin, the company has developed a decentralized, high-rate treatment technology that integrates rapid solids removal with a proprietary advanced oxidation process. This fully automated system is versatile, catering to various applications, including municipal wastewater treatment, industrial high-strength waste management, and emergency scenarios requiring mobile or compact solutions. By providing reliable and cost-effective wastewater management options, Rapid Radicals Technology supports clients in fostering a more resilient water infrastructure.

EWPanel

Grant in 2019
EWPanel manufactures powerless, flexible sensor subfloor mats made of natural materials. The company was founded in 2016 by Chunhua Yao and Xudong Wang.

DataChat

Grant in 2019
DataChat, Inc. specializes in developing a data analytics platform that leverages Conversational Intelligence technology, allowing users to interact with their data through natural language conversations. Founded in 2017 and based in Madison, Wisconsin, the platform enables a wide array of data analytics functions, including exploratory and predictive analytics, structured and free search querying, and data visualization. Users can also create and share analytical recipes, collaborate on data science projects, and uncover patterns within their data, translating complex findings into easily understandable insights. By integrating real-time analytics capabilities, DataChat empowers clients to make informed business decisions quickly and effectively.

Filament Games

Grant in 2019
Operator of a digital studio intended to provide learning game development services. The company develops educational video games specializing in the creation of game-play mechanics that are also accurate representations of educational content, helping players transform their play experience into real-world knowledge, and learn while they play.

COnovate

Grant in 2019
SafeLi is a startup that develops lithium-ion battery parts made from a graphene monoxide that boosts the energy storage capacity of li-ion batteries. The company develops and commercializes products covered by the licensed patent in all fields of use, with an initial focus on Lithium-Ion batteries. These materials are based on abundant, non-toxic starting materials that offer low-cost, safer, and higher capacity alternatives to graphite-only anode batteries. Batteries with patented materials demonstrates higher capacity and faster charge rates than graphite. It was founded in 2016 by Drs. Carol Hirschmugl and Marija Gajdardziska-Josifovska in Milwaukee, Wisconsin.

Pyran

Grant in 2019
Pyran LLC specializes in developing a starting compound for the production of paints and plastic chemicals. Founded in 2017 and based in Madison, Wisconsin, the company creates a diol product derived from renewable wood and crop waste resources. This diol serves as a raw material for various applications, including digital versatile discs, paints, bottles, coatings, plastics, ropes, glues, and adhesives. Pyran primarily caters to the chemical industries, focusing on sustainable solutions for paint and plastic manufacturing.

Imagen Energy

Grant in 2018
developer of solar energy solutions designed for grid, microgrid, energy efficiency, and energy reliability support. The company's offerings include solar panel installations, battery storage systems, and monitoring tools, generating clean electricity, storing excess solar energy, enabling businesses and homeowners to become more energy independent and potentially reducing their reliance on the traditional grid.
Cell Reprogramming & Therapeutics, founded in 2013 and based in Wauwatosa, Wisconsin, specializes in developing innovative cell reprogramming technologies aimed at treating central nervous system diseases. These technologies facilitate the generation of stem cell lines and specific differentiated cell types from patients' somatic cells, which can be utilized for disease modeling, toxicity screening, and drug discovery. By enabling researchers to create advanced cellular models, the company contributes to the development of therapeutics for various neurological disorders, thereby opening new avenues for treatment and enhancing understanding of these complex conditions.

Plumb Pharmaceuticals

Grant in 2018
Developer of advanced quantload technology designed for producing super-extended-release formulations of weak-base, small-molecule drugs. The company's lipid nanoparticle technology offers, stimulants for treating ADHD, anti-HIV drugs, antibiotics, antipsychotics, cancer chemotherapy agents, antihistamines, and analgesics, enabling the healthcare industry to improve human health.

SHINE Technologies

Series B in 2018
SHINE Medical Technologies, LLC is a manufacturer and supplier of medical tracers and cancer treatment elements, specializing in isotopes used for diagnostic and therapeutic purposes. The company produces molybdenum-99, which is essential for imaging and diagnosing conditions such as cancer and heart disease. Additionally, SHINE offers Iodine-131 for the treatment of thyroid cancer and related conditions, as well as Iodine-125, which is utilized in brachytherapy for various cancers. The company also provides Xenon-133, an inhalable gas that assists in evaluating lung function and blood flow in the brain. Founded in 2010 and headquartered in Janesville, Wisconsin, SHINE serves both domestic and international markets with its innovative medical solutions.

Carroll University

Grant in 2018
Carroll University, located in Waukesha, Wisconsin, is dedicated to fostering student potential through integrated learning and skill training, while promoting enduring values and community engagement. The institution honors a Christian tradition but remains inclusive, welcoming students from all backgrounds. With a diverse range of undergraduate programs, including fields such as Accounting, Diagnostic Medical Sonography, and Theatre Arts, as well as graduate offerings in areas like Physical Therapy and Business Administration, Carroll provides comprehensive academic opportunities. The university encourages student involvement through over 50 clubs, including Greek life and service organizations, allowing for a vibrant campus life. The admissions process evaluates applicants based on academic performance, extracurricular activities, and community service, while financial aid is available to those demonstrating need. Additionally, Carroll University manages an endowment fund, with earnings supporting scholarships, research, and various academic programs, all overseen by its board of trustees.

DataChat

Grant in 2017
DataChat, Inc. specializes in developing a data analytics platform that leverages Conversational Intelligence technology, allowing users to interact with their data through natural language conversations. Founded in 2017 and based in Madison, Wisconsin, the platform enables a wide array of data analytics functions, including exploratory and predictive analytics, structured and free search querying, and data visualization. Users can also create and share analytical recipes, collaborate on data science projects, and uncover patterns within their data, translating complex findings into easily understandable insights. By integrating real-time analytics capabilities, DataChat empowers clients to make informed business decisions quickly and effectively.

URTPC

Grant in 2017
URTPC develops power conversion technology that can be used in a variety of power conversion applications. URTPC aims to help companies sustain enthusiasm and create more reliable, safer, efficient products that get to market faster. URTPC intends to be a one-stop solution for analyzing electrical, power electronics, and electromagnetic components, as well as a control system, thermal, structural, and electromagnetic operating parameters.

systeMECH

Grant in 2017
systeMECH specializes in developing innovative and scalable manufacturing processes, particularly focusing on bonding and layer transfer technologies. Founded in 2011 by David Grierson and Kevin Turner, the company aims to commercialize advancements from research at the University of Wisconsin-Madison. Its core services revolve around creating small-scale manufacturing techniques for flexible micro- and nano-scale devices. systeMECH offers expertise in micro- and nanofabrication, emphasizing methods to fabricate advanced flexible electronics, photonics, MEMS, and semiconductor devices. By enabling the direct transfer of high-performance materials and devices to flexible substrates, the company supports researchers and innovators in enhancing their applications across various industries.

Flexcompute

Grant in 2017
FLEXCOMPUTE is an IT company specialized in providing solutions related to simulation.

SciArt Software

Grant in 2017
SciArt Software, Inc. specializes in developing topology optimization software that enhances the design process for physical parts through generative design. Founded in 2018 and based in Madison, Wisconsin, the company offers a range of products including ParetoCreo, an add-in for design analysis; ParetoWin, a CAD-agnostic topology optimization tool; ParetoCloud, a cloud-based solution for finite element analysis and topology optimization; and ParetoWorks, a subscription service for design analysis. SciArt's technology allows users to optimize material distribution based on specific strength and functionality requirements, significantly reducing manufacturing costs while preserving structural integrity. The software delivers insights to engineers approximately 60 times faster than traditional solutions, effectively doubling the design cycle speed.

Thalchemy

Grant in 2017
Thalchemy Corp. develops neurally-inspired algorithms and accelerators aimed at continuous sensory processing in smartphones and other battery-operated devices. By mimicking the functionality of the mammalian thalamus, the company's technology allows for the routing, filtering, and preprocessing of sensory data, which enhances the detection of complex gestures and hot words across multiple modalities. This innovative approach significantly extends battery life for devices such as smartphones and wearables, while providing optimized voice and gesture control. Thalchemy's solutions also support the creation of always-on applications, simplifying development through an automated, user-friendly interface. Additionally, the technology can monitor environmental conditions, enabling applications that alert users or caregivers in emergency situations, such as falls or irregular heartbeats. Founded in 2012 and based in Madison, Wisconsin, Thalchemy aims to transform user interfaces and experiences across a variety of sensing platforms.

ConsortiEX

Grant in 2017
ConsortiEX Inc. is a health care technology company based in Milwaukee, Wisconsin, established in 2013. It specializes in providing information technology systems and services tailored for pharmacies, specifically to assist hospitals in managing the ordering, distribution, and tracking of pharmaceuticals. The company's flagship product, Assure-Trak, is an enterprise resource planning system that facilitates the collection, integration, management, and sharing of pharmacy information, particularly for the compounding of sterile products. In addition to this, ConsortiEX offers a range of services, including pedigree management, IV workflow management, inventory and logistics management, and quality management reporting. The company also provides compliance solutions for the Drug Supply Chain Security Act and e-commerce order management services, supporting the needs of member institutions and their affiliates in the health care sector.

Varigen

Grant in 2016
Varigen Biosciences is developing new technologies for capturing and expressing natural product pathways. Learn about our DNAtrap™ custom cloning service which delivers verified clones of your DNA target (up to 100 kb) in just 10 days at http://varigenbiosciences.com/dnatrap-custom-cloning-service/. Learn about how our BigDNA™ metagenomics libraries can revolutionize natural product discovery at http://varigenbiosciences.com/products/.

Imagen Energy

Grant in 2016
developer of solar energy solutions designed for grid, microgrid, energy efficiency, and energy reliability support. The company's offerings include solar panel installations, battery storage systems, and monitoring tools, generating clean electricity, storing excess solar energy, enabling businesses and homeowners to become more energy independent and potentially reducing their reliance on the traditional grid.

Filament Games

Grant in 2016
Operator of a digital studio intended to provide learning game development services. The company develops educational video games specializing in the creation of game-play mechanics that are also accurate representations of educational content, helping players transform their play experience into real-world knowledge, and learn while they play.

Xylome

Grant in 2016
Xylome offers solutions that enable first generation biofuel manufacturers to use second generation technology solutions in their manufacturing process. It offers them with advisory, implementation, and support services. Xylome develops a range of non-conventional yeasts and yeast technology solutions for experimental assessments. Xylome was founded by Thomas W Jeffries in 2007. It is based in Madison, Wisconsin.

GlucanBio

Grant in 2016
GlucanBio is a developer of innovative biomass conversion technology that focuses on producing furan derivatives such as furfural, HMF, DMF, THF, and FDCA. Originating from research at the University of Wisconsin and the Center for Biorenewable Chemicals at Iowa State, the company's processes fractionize biomass under mild conditions, resulting in cost-effective production of specialty and commodity chemicals. This approach not only enhances performance but also supports clients in transitioning toward sustainable practices. With a team that includes experts in catalysis and early-stage commercialization, GlucanBio is well-equipped to address technical challenges in the industry and capitalize on strong market opportunities.

PhylloTech

Grant in 2016
PhylloTech is focused on producing proteins and antibodies through a continuous plant expression system utilizing glandular secreting trichomes of Nicotiana tabacum. This innovative approach enables the production of difficult-to-manufacture proteins in a cost-effective manner. The system allows proteins to be secreted onto leaf surfaces, where they can be easily recovered with an extraction buffer, eliminating the need for time-consuming purification processes. This method not only reduces production costs but also facilitates rapid scalability, allowing for the cultivation of tens of thousands of plants. PhylloTech's environmentally-friendly system relies on basic inputs like light, water, and fertilizer, making it suitable for efficient growth in greenhouses or fields using existing agricultural practices. Additionally, the company aims to address plant disease challenges and enhance crop yields by employing enzymes to control bacterial pathogens, thereby reducing reliance on synthetic pesticides and microbial biocontrols.

Flexcompute

Grant in 2015
FLEXCOMPUTE is an IT company specialized in providing solutions related to simulation.

Thalchemy

Grant in 2015
Thalchemy Corp. develops neurally-inspired algorithms and accelerators aimed at continuous sensory processing in smartphones and other battery-operated devices. By mimicking the functionality of the mammalian thalamus, the company's technology allows for the routing, filtering, and preprocessing of sensory data, which enhances the detection of complex gestures and hot words across multiple modalities. This innovative approach significantly extends battery life for devices such as smartphones and wearables, while providing optimized voice and gesture control. Thalchemy's solutions also support the creation of always-on applications, simplifying development through an automated, user-friendly interface. Additionally, the technology can monitor environmental conditions, enabling applications that alert users or caregivers in emergency situations, such as falls or irregular heartbeats. Founded in 2012 and based in Madison, Wisconsin, Thalchemy aims to transform user interfaces and experiences across a variety of sensing platforms.

ConsortiEX

Grant in 2015
ConsortiEX Inc. is a health care technology company based in Milwaukee, Wisconsin, established in 2013. It specializes in providing information technology systems and services tailored for pharmacies, specifically to assist hospitals in managing the ordering, distribution, and tracking of pharmaceuticals. The company's flagship product, Assure-Trak, is an enterprise resource planning system that facilitates the collection, integration, management, and sharing of pharmacy information, particularly for the compounding of sterile products. In addition to this, ConsortiEX offers a range of services, including pedigree management, IV workflow management, inventory and logistics management, and quality management reporting. The company also provides compliance solutions for the Drug Supply Chain Security Act and e-commerce order management services, supporting the needs of member institutions and their affiliates in the health care sector.

AmebaGone

Grant in 2015
AmebaGone Inc. addresses the critical challenge of antibiotic resistance, which poses significant threats in agriculture, medicine, and industry. With the decline in the development of new antibiotics, the company is pioneering innovative antimicrobial strategies utilizing its proprietary technology based on free-living phagocytes. These naturally occurring cells and their secreted products are effective in combating bacterial pathogens, including those enmeshed in biofilms, which traditional antibiotics struggle to eliminate. AmebaGone's solutions are designed to treat infections in crops, animals, and humans, offering a vital alternative in the face of rising antibiotic resistance. The company has received funding from the National Science Foundation, the National Institutes of Health, the Wisconsin Economic Development Corporation, and the Madison Development Corporation to support its mission.

C-Motive

Grant in 2015
C-Motive Technologies Inc., founded in 2012 and based in Madison, Wisconsin, specializes in manufacturing innovative electric motors that leverage electrostatic forces, a technology often referred to as "static cling." The company aims to revolutionize the electric motor industry by developing high-efficiency motors that are free of rare-earth metals, thereby addressing sustainability concerns. C-Motive's motors utilize lightweight metals, plastics, and dielectric materials to significantly reduce weight and improve efficiency, offering double the power at half the weight compared to traditional motors. With an efficiency rate exceeding 90% in direct drive applications, these motors are designed for a range of uses, including industrial applications, e-mobility, and renewable energy generation. The company's commitment to decarbonization positions it as a forward-thinking player in the evolving landscape of electric motor technology.

Xylome

Grant in 2015
Xylome offers solutions that enable first generation biofuel manufacturers to use second generation technology solutions in their manufacturing process. It offers them with advisory, implementation, and support services. Xylome develops a range of non-conventional yeasts and yeast technology solutions for experimental assessments. Xylome was founded by Thomas W Jeffries in 2007. It is based in Madison, Wisconsin.

GlucanBio

Grant in 2015
GlucanBio is a developer of innovative biomass conversion technology that focuses on producing furan derivatives such as furfural, HMF, DMF, THF, and FDCA. Originating from research at the University of Wisconsin and the Center for Biorenewable Chemicals at Iowa State, the company's processes fractionize biomass under mild conditions, resulting in cost-effective production of specialty and commodity chemicals. This approach not only enhances performance but also supports clients in transitioning toward sustainable practices. With a team that includes experts in catalysis and early-stage commercialization, GlucanBio is well-equipped to address technical challenges in the industry and capitalize on strong market opportunities.

systeMECH

Grant in 2015
systeMECH specializes in developing innovative and scalable manufacturing processes, particularly focusing on bonding and layer transfer technologies. Founded in 2011 by David Grierson and Kevin Turner, the company aims to commercialize advancements from research at the University of Wisconsin-Madison. Its core services revolve around creating small-scale manufacturing techniques for flexible micro- and nano-scale devices. systeMECH offers expertise in micro- and nanofabrication, emphasizing methods to fabricate advanced flexible electronics, photonics, MEMS, and semiconductor devices. By enabling the direct transfer of high-performance materials and devices to flexible substrates, the company supports researchers and innovators in enhancing their applications across various industries.

HealthMyne

Grant in 2015
HealthMyne, Inc. is a healthcare informatics company based in Madison, Wisconsin, established in 2013. It specializes in providing innovative search, analytics, and imaging solutions primarily for cancer care providers. The company's smart imaging technology supports clinical decision-making by offering real-time, evidence-based insights that enhance diagnostic accuracy and foster collaboration among healthcare professionals. HealthMyne's platform includes features such as automatic tumor staging, dose overlays, specialized reporting, and management of incidental findings, all aimed at improving patient care and optimizing the efficiency of clinical workflows. By integrating electronic health record capabilities with advanced imaging solutions, HealthMyne seeks to reduce care delivery costs while ensuring that clinicians have access to relevant patient information for informed treatment decisions.

PhylloTech

Grant in 2015
PhylloTech is focused on producing proteins and antibodies through a continuous plant expression system utilizing glandular secreting trichomes of Nicotiana tabacum. This innovative approach enables the production of difficult-to-manufacture proteins in a cost-effective manner. The system allows proteins to be secreted onto leaf surfaces, where they can be easily recovered with an extraction buffer, eliminating the need for time-consuming purification processes. This method not only reduces production costs but also facilitates rapid scalability, allowing for the cultivation of tens of thousands of plants. PhylloTech's environmentally-friendly system relies on basic inputs like light, water, and fertilizer, making it suitable for efficient growth in greenhouses or fields using existing agricultural practices. Additionally, the company aims to address plant disease challenges and enhance crop yields by employing enzymes to control bacterial pathogens, thereby reducing reliance on synthetic pesticides and microbial biocontrols.

Radom

Grant in 2014
Radom is a developer of plasma technology that aims to enhance microwave-induced plasma applications. Founded with the goal of solving complex engineering challenges in radio frequency and RF plasma sources, the company focuses on bridging technology gaps in atomic spectroscopy and microwave plasma markets. By creating innovative applications that complement existing technologies, Radom seeks to expand the use of microwave-induced plasma into optical and mass spectroscopy sectors. This strategy enables various industries to improve scientific outcomes and enhance overall business performance.

Thalchemy

Grant in 2014
Thalchemy Corp. develops neurally-inspired algorithms and accelerators aimed at continuous sensory processing in smartphones and other battery-operated devices. By mimicking the functionality of the mammalian thalamus, the company's technology allows for the routing, filtering, and preprocessing of sensory data, which enhances the detection of complex gestures and hot words across multiple modalities. This innovative approach significantly extends battery life for devices such as smartphones and wearables, while providing optimized voice and gesture control. Thalchemy's solutions also support the creation of always-on applications, simplifying development through an automated, user-friendly interface. Additionally, the technology can monitor environmental conditions, enabling applications that alert users or caregivers in emergency situations, such as falls or irregular heartbeats. Founded in 2012 and based in Madison, Wisconsin, Thalchemy aims to transform user interfaces and experiences across a variety of sensing platforms.

Alpha Universe

Grant in 2014
Provider of biotechnology products and services intended to back in the detection and inactivation of pathogens including biothreat agents. The company's products and services are based on the aspects of molecular and cellular biology to detect or find traits about hereditary that will assist in future genetic approaches, enabling researchers to research in an enhanced way.

Imbed Biosciences

Grant in 2013
Imbed Biosciences, Inc. is a medical device company based in Madison, Wisconsin, focused on developing innovative technologies for embedding bioactive molecules in wound dressings and surgical implants. The company specializes in antibacterial silver nanofilms that facilitate the sustained release of non-toxic silver, offering effective wound care for extended periods. By utilizing its advanced biomaterials platforms, Imbed aims to enhance wound dressings to prevent infections and promote faster healing, addressing a significant market opportunity in the management of surgical and chronic wounds, valued at $3 billion in the U.S. and Europe. Founded in 2010 as a spin-off from the University of Wisconsin-Madison, Imbed is backed by extensive research and a team with over 25 years of collective experience in clinical wound management.

C-Motive

Grant in 2013
C-Motive Technologies Inc., founded in 2012 and based in Madison, Wisconsin, specializes in manufacturing innovative electric motors that leverage electrostatic forces, a technology often referred to as "static cling." The company aims to revolutionize the electric motor industry by developing high-efficiency motors that are free of rare-earth metals, thereby addressing sustainability concerns. C-Motive's motors utilize lightweight metals, plastics, and dielectric materials to significantly reduce weight and improve efficiency, offering double the power at half the weight compared to traditional motors. With an efficiency rate exceeding 90% in direct drive applications, these motors are designed for a range of uses, including industrial applications, e-mobility, and renewable energy generation. The company's commitment to decarbonization positions it as a forward-thinking player in the evolving landscape of electric motor technology.

AmebaGone

Grant in 2013
AmebaGone Inc. addresses the critical challenge of antibiotic resistance, which poses significant threats in agriculture, medicine, and industry. With the decline in the development of new antibiotics, the company is pioneering innovative antimicrobial strategies utilizing its proprietary technology based on free-living phagocytes. These naturally occurring cells and their secreted products are effective in combating bacterial pathogens, including those enmeshed in biofilms, which traditional antibiotics struggle to eliminate. AmebaGone's solutions are designed to treat infections in crops, animals, and humans, offering a vital alternative in the face of rising antibiotic resistance. The company has received funding from the National Science Foundation, the National Institutes of Health, the Wisconsin Economic Development Corporation, and the Madison Development Corporation to support its mission.

NanoAffix

Grant in 2013
NanoAffix Science Has developed technology for real-time detection of contaminants in drinking water. Graphene-based sensors with nanometer-thick layers enable rapid and inexpensive quantitative onsite testing for lead in tap water.NanoAffix Science LLC (NAFX) is a spin-off small business formed around exclusively licensed patented technologies from the University of Wisconsin-Milwaukee Research Foundation. The mission of NAFX is “Inventing the future of sensing – cleaner, smarter, digital water.” The company has recently received equity investments from three water manufacturing companies (A. O. Smith, Badger Meter, and Baker Manufacturing) to prototype real-time water sensor chips using a graphene transistor technology.

HealthMyne

Grant in 2013
HealthMyne, Inc. is a healthcare informatics company based in Madison, Wisconsin, established in 2013. It specializes in providing innovative search, analytics, and imaging solutions primarily for cancer care providers. The company's smart imaging technology supports clinical decision-making by offering real-time, evidence-based insights that enhance diagnostic accuracy and foster collaboration among healthcare professionals. HealthMyne's platform includes features such as automatic tumor staging, dose overlays, specialized reporting, and management of incidental findings, all aimed at improving patient care and optimizing the efficiency of clinical workflows. By integrating electronic health record capabilities with advanced imaging solutions, HealthMyne seeks to reduce care delivery costs while ensuring that clinicians have access to relevant patient information for informed treatment decisions.

Interfacial Solutions

Grant in 2013
Interfacial Solutions is a prominent provider of contract research and development services for the plastics industry, established in 2003. The company focuses on assisting innovators in bringing their ideas to fruition, having helped commercialize over $300 million in innovative plastic products across various markets. With a dedicated team of approximately thirty specialists, Interfacial Solutions offers expertise in advanced materials and manufacturing processes tailored to sectors such as building and construction, electronics, automotive, recycling, and specialty chemicals. Their services include the development of niche specialty compounds, masterbatches, and engineered substrates, enabling clients to achieve timely and effective solutions for their product development needs.

Thalchemy

Grant in 2013
Thalchemy Corp. develops neurally-inspired algorithms and accelerators aimed at continuous sensory processing in smartphones and other battery-operated devices. By mimicking the functionality of the mammalian thalamus, the company's technology allows for the routing, filtering, and preprocessing of sensory data, which enhances the detection of complex gestures and hot words across multiple modalities. This innovative approach significantly extends battery life for devices such as smartphones and wearables, while providing optimized voice and gesture control. Thalchemy's solutions also support the creation of always-on applications, simplifying development through an automated, user-friendly interface. Additionally, the technology can monitor environmental conditions, enabling applications that alert users or caregivers in emergency situations, such as falls or irregular heartbeats. Founded in 2012 and based in Madison, Wisconsin, Thalchemy aims to transform user interfaces and experiences across a variety of sensing platforms.

Alpha Universe

Grant in 2013
Provider of biotechnology products and services intended to back in the detection and inactivation of pathogens including biothreat agents. The company's products and services are based on the aspects of molecular and cellular biology to detect or find traits about hereditary that will assist in future genetic approaches, enabling researchers to research in an enhanced way.

Interfacial Solutions

Grant in 2012
Interfacial Solutions is a prominent provider of contract research and development services for the plastics industry, established in 2003. The company focuses on assisting innovators in bringing their ideas to fruition, having helped commercialize over $300 million in innovative plastic products across various markets. With a dedicated team of approximately thirty specialists, Interfacial Solutions offers expertise in advanced materials and manufacturing processes tailored to sectors such as building and construction, electronics, automotive, recycling, and specialty chemicals. Their services include the development of niche specialty compounds, masterbatches, and engineered substrates, enabling clients to achieve timely and effective solutions for their product development needs.

Filament Games

Grant in 2012
Operator of a digital studio intended to provide learning game development services. The company develops educational video games specializing in the creation of game-play mechanics that are also accurate representations of educational content, helping players transform their play experience into real-world knowledge, and learn while they play.

PhylloTech

Grant in 2012
PhylloTech is focused on producing proteins and antibodies through a continuous plant expression system utilizing glandular secreting trichomes of Nicotiana tabacum. This innovative approach enables the production of difficult-to-manufacture proteins in a cost-effective manner. The system allows proteins to be secreted onto leaf surfaces, where they can be easily recovered with an extraction buffer, eliminating the need for time-consuming purification processes. This method not only reduces production costs but also facilitates rapid scalability, allowing for the cultivation of tens of thousands of plants. PhylloTech's environmentally-friendly system relies on basic inputs like light, water, and fertilizer, making it suitable for efficient growth in greenhouses or fields using existing agricultural practices. Additionally, the company aims to address plant disease challenges and enhance crop yields by employing enzymes to control bacterial pathogens, thereby reducing reliance on synthetic pesticides and microbial biocontrols.

Platypus Technology

Grant in 2012
Platypus Technologies develops analytical and life sciences products based upon the application of nanotechnology and materials science.

Interfacial Solutions

Grant in 2012
Interfacial Solutions is a prominent provider of contract research and development services for the plastics industry, established in 2003. The company focuses on assisting innovators in bringing their ideas to fruition, having helped commercialize over $300 million in innovative plastic products across various markets. With a dedicated team of approximately thirty specialists, Interfacial Solutions offers expertise in advanced materials and manufacturing processes tailored to sectors such as building and construction, electronics, automotive, recycling, and specialty chemicals. Their services include the development of niche specialty compounds, masterbatches, and engineered substrates, enabling clients to achieve timely and effective solutions for their product development needs.

Echometrix

Grant in 2012
Echometrix was founded to create products that apply the theory of acoustoelasticity (AE) to the advanced evaluation of biological materials. Our first product offering is trademarked EchoSoft. It is ultrasound-based analytical software, which uses AE to provide an advanced, non-invasive, functional evaluation of ligament, tendon and muscle injuries. EchoSoft is now in use across the globe by opinion leading researchers in biomechanics and medical imaging and will be available for general clinical use in late 2012.

SolRayo

Grant in 2012
SolRayo, Inc. specializes in the development of nanoparticle-based materials aimed at enhancing renewable energy solutions and various industrial applications. The company focuses on addressing performance degradation in lithium-ion batteries by utilizing its innovative nanoparticle technology. In addition, SolRayo has created ultracapacitor technology that integrates nanoparticles with standard carbon sheets, resulting in a cost-effective and easily implementable solution. This technology significantly improves the performance of ultracapacitors, enabling them to serve as efficient clean energy storage devices. Through these advancements, SolRayo aims to transform energy utilization and support environmentally friendly practices across multiple sectors.
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