The National Science Foundation (NSF), established in 1950 and located in Alexandria, Virginia, is an independent federal agency dedicated to advancing fundamental research and education across all scientific and engineering disciplines. With an annual budget of approximately $7.8 billion, the NSF operates America's Seed Fund, which allocates nearly $200 million each year to support startups and small businesses through the Small Business Innovation Research (SBIR) program. This initiative provides non-dilutive funding of up to $1.5 million to assist in research and development efforts, thereby facilitating the transformation of scientific discoveries into commercially viable products and services. By helping to de-risk technology, the NSF plays a crucial role in fostering innovation and addressing societal challenges through scientific advancements.
BioSuperior is a preclinical stage biotherapeutics company developing cost-effective, non-invasive, and easily accessible technologies to cure lung disease and repair damaged lung tissue. They have bio-engineered a novel synthetic pulmonary surfactant prototype, BioSurf, an essential biomaterial required for breathing and having direct therapeutic effects that will be used to deliver potent drugs that restore normal lung function.
Re-Synth International specializes in developing environmental technologies that enhance the quality and efficiency of hydrocarbon fuels. The company’s patented solutions focus on reducing the cost of clean fuel by effectively eliminating contaminants without generating harmful by-products or altering fuel viscosity. This innovation not only improves fuel efficiency but also significantly lowers the environmental impact associated with fuel consumption, enabling users to minimize their carbon footprint. By prioritizing both cost-effectiveness and sustainability, Re-Synth International aims to contribute positively to the energy sector while addressing the growing demand for cleaner fuel alternatives.
Developer of a photo-bioreactor system intended for algae cultivation. The company's system is composed of a metal support cage, a plastic bladder containing culture volume, and a sterile harvest apparatus for the continual collection of pre-concentrated culture, equipped with both pH and temperature control options, enabling production facilities to reduce their carbon footprint and maintain a low rate of water consumption, in order to minimize their impact on the local and global environment.
Boron Nitride Power develops functionalized 2D materials to simultaneously achieve high energy and power density electrochemical energy storage with thermal stability and an environmentally benign and economic composition. Their cathode materials include functionalized hexagonal boron nitride and graphene and are improved versions of the well-known graphene oxide cathode, especially in terms of thermal stability.
ChloBis Water specializes in innovative electrochemical technologies, specifically the development of a desalination battery. This technology integrates energy storage with the removal of sodium and chlorine from saltwater. The battery is constructed using bismuth as a chloride-storage electrode and sodium as a sodium-storage electrode, allowing it to efficiently desalinate water while simultaneously storing and releasing energy through the manipulation of salt ions. By addressing the challenges at the intersection of water and energy, ChloBis Water offers a solution that enhances energy efficiency and contributes to sustainable water management.
SIEV Technologies, founded in 2020 and based in Fayetteville, Arkansas, specializes in catalytic membrane technology aimed at transforming biomass waste into valuable bio-products. The company's innovative approach involves designing and fabricating a tunable catalyst that functions similarly to natural enzymes, achieving high selectivity and conversion rates. Unlike traditional enzymes, SIEV's technology can operate at elevated temperatures with greater efficiency, allowing clients to harness a diverse array of biomass sources for the production of sustainable chemicals. This advancement positions SIEV at the forefront of the bio-products sector, promoting environmental sustainability through the effective utilization of waste materials.
Biko Biolabs is a research company founded in 2020 and located in Somerville, Massachusetts, that focuses on the intersection of plastic waste and regenerative agriculture. The company aims to address research and development gaps related to sustainability and self-sufficiency in traditionally marginalized communities. By providing resources to innovators, Biko Biolabs fosters the creation of new economic opportunities and trains emerging local scientists and engineers. The company emphasizes impactful research that is closely aligned with the specific needs of the communities involved, enabling tailored scientific practices and technologies that directly address fundamental community challenges.
ZiTechnologies provides end product pellets with reduced chlorine content that are suitable for power and heat applications. They offer pellets that can be used to replace coal.
Cruz Foam, Inc. is a manufacturer of structural foams that addresses the global challenge of plastic pollution. Founded in 2017 and based in Santa Cruz, California, the company transforms chitin, a biopolymer derived from shrimp shells, into eco-friendly foam products. These biodegradable alternatives serve as a sustainable solution to traditional petroleum-based foams and are utilized across various sectors, including consumer packaging, consumer electronics, automotive, and B2B applications. By leveraging waste materials from the seafood industry, Cruz Foam offers scalable and compostable options that align with existing supply chains and maintain competitive pricing. The company's innovations aim to empower industry leaders to contribute to a cleaner environment while reducing reliance on single-use plastics.
Caribou Biofuels manufactures biofuels for the conversion of biomass into fuels. The company was established in 2017 and is based in Modesto, California.
Jet-Set Offset is a donation-based carbon-offsetting tool for air travel, and a consumer-friendly alternative to the traditional carbon marketplace. Our site operates as a fundraising tool for environmental nonprofit organizations and facilitates automatic, mileage-based donations from travelers' flights. We've developed this approach to raise awareness of the environmental impact of air travel and inspire eco-conscious travelers and businesses to take action. Travelers and companies can subscribe to Jet-Set Offset and choose to support a nonprofit organization automatically with a one cent-per-mile donation every time they, or their employees, fly. Our nonprofit partners are working towards local climate solutions across the country, operating certified carbon offset and credit projects, as well as advocacy, education, renewable energy, reforestation, and/or conservation programs.
Rarebird, founded in 2020 and based in Oakland, California, specializes in producing a coffee alternative that replaces traditional caffeine. The company offers Paraxanthine coffee, a beverage designed to enhance alertness without the negative side effects commonly associated with caffeine, such as jitters and anxiety. This innovative product aims to cater to individuals who are sensitive to caffeine while providing a suitable option for those seeking increased focus and energy. Rarebird is committed to transforming the coffee experience by introducing a healthier alternative to conventional caffeinated beverages.
Natural Fiber Welding, Inc. is a manufacturer and supplier of innovative fabrics and materials, utilizing technology that transforms plants and natural fibers into durable textiles and products. Founded in 2015 and based in Peoria, Illinois, the company focuses on harnessing renewable resources to create sustainable alternatives to synthetic materials. By leveraging abundant local resources, Natural Fiber Welding aims to develop scalable solutions that are accessible to diverse communities, enhancing the quality and usability of their products while minimizing processing costs. The company’s commitment to sustainability and innovation positions it as a leader in the movement toward environmentally friendly materials.
Biomilitus is a biotechnology company that intends to use insect larvae to produce animal feed with less land and a lower carbon footprint. The company was founded in 2019 and is headquartered in Sacramento, California.
Symbrosia is a California-based company founded in 2018 that produces a cattle feed supplement designed to reduce methane emissions. The company has developed a symbiotic system to cultivate macroalgae, specifically seaweed, which is incorporated into cattle feed. This innovative approach not only aims to mitigate the environmental impact of livestock farming but also promotes sustainable practices in the agricultural sector. By focusing on the integration of sustainable seafood into their products, Symbrosia seeks to address the significant challenge of methane emissions generated by cattle.
Spira is a company focused on producing algae-based ingredients that aim to replace petroleum and animal-derived compounds, promoting sustainability. By utilizing cyanobacteria, Spira develops industrial ingredients that serve various sectors, including beverages, cosmetics, textiles, and confectionery. The company collaborates with a global network of farming partners to manufacture raw materials that not only reduce reliance on petrochemicals but also support carbon capture and wastewater management efforts. Additionally, Spira's initiatives assist farmers in developing countries, contributing to a transition towards healthier materials and more sustainable practices across industries.
Cellulose Sciences International develops novel methods for utilizing celluloses and lignocellulosic. The headquarters of the company are in Madison, Wisconsin.
ReSource Chemical is a company based in Berkeley, California, focused on developing high-performance plastics derived from carbon dioxide. The company utilizes a proprietary bio-based platform to create chemicals that enable the production of environmentally friendly plastics with superior physical properties compared to traditional fossil fuel-based plastics. By converting CO2 into these innovative materials, ReSource Chemical aims to provide sustainable alternatives that do not contribute to environmental pollution.
Ecolectro makes materials that make clean fuels and chemicals. The company is commercializing a proprietary platform of novel polymers that are best in class, allowing its customers to produce devices that last longer and cost less. Ecolectro has defensible IP, state-of-the-art facilities, experienced personnel, and strong customer traction.
ZestBio, Inc., founded in 2017 and based in Berkeley, California, specializes in transforming agricultural waste into renewable products. The company develops innovative technologies to extract value from byproducts such as orange juice peel waste, sugar beet pulp, and grape pomace. By converting these low-value materials into specialty chemicals, ZestBio produces household cleaning ingredients, bio-based plastics, and vitamins. This approach not only creates eco-friendly products but also offers customers renewable alternatives at a reasonable cost.
RenewCO2 is a research company established in 2018 and located in Cranford, New Jersey. The company focuses on developing clean electrochemical processes that convert carbon dioxide emissions into useful polymers and chemicals. By specializing in these innovative methods, RenewCO2 aims to assist organizations in the chemical industry in reducing their environmental impact while also creating sustainable products from waste materials. Through its technology, the company seeks to transform CO2 into valuable monomers and other organic chemicals, contributing to a more sustainable and eco-friendly chemical manufacturing landscape.
Mobius provides environmental solutions that convert waste streams into chemicals and materials. At Mobius, we're creating a world where There’s Wonder in Waste. We’re a mission-driven company focused on eliminating waste by leveraging industrial organic waste streams from agriculture, forestry, paper and biofuel & biorefining industries to create new materials and chemicals. Our first product is a proprietary, biodegradable polymer made from lignin, a natural material found in all grasses and trees that is produced as waste at a rate of over 50 million tons each year by the paper and biofuel industries. With this biopolymer, we are creating a bio-based, biodegradable plastic pellets for applications in horticulture, agriculture, food service packaging, and beyond.
Cruz Foam, Inc. is a manufacturer of structural foams that addresses the global challenge of plastic pollution. Founded in 2017 and based in Santa Cruz, California, the company transforms chitin, a biopolymer derived from shrimp shells, into eco-friendly foam products. These biodegradable alternatives serve as a sustainable solution to traditional petroleum-based foams and are utilized across various sectors, including consumer packaging, consumer electronics, automotive, and B2B applications. By leveraging waste materials from the seafood industry, Cruz Foam offers scalable and compostable options that align with existing supply chains and maintain competitive pricing. The company's innovations aim to empower industry leaders to contribute to a cleaner environment while reducing reliance on single-use plastics.
HelioBioSys is a biotechnology company that specializes in marine cyanobacteria. The company uses marine cyanobacteria that grow on air, seawater, and sunlight. They produce a variety of complex biopolymers. HelioBioSys has developed cost-effective ways to harvest and process them into concentrated polysaccharides and hydrogels. These sustainably-derived biomaterials have applications in cosmetics, sunscreens and bioplastics.
Developer of molecular technology for tires intended to improve vehicle fuel economy. The company's technology combines biotechnology and nanotechnology to improve mobility by using composite materials to reduce friction in tires, enabling the logistic industry to reduce fuel consumption and increase profits.
Algenesis is a material science and technology company focused on addressing the environmental challenges posed by fossil fuel-based products. It specializes in manufacturing renewable and biodegradable plastic materials derived from algae. The company develops biodegradable polyurethane foam products, including soft foams suitable for footwear and hard foams designed for surfboards. By creating these innovative materials, Algenesis aims to help businesses tackle the global plastic pollution crisis and promote more sustainable alternatives in various industries.
Sylvatex Inc. is a fuel technology company focused on developing innovative solutions for cleaner-burning fuels. Founded in 2007 and based in San Francisco, California, the company has created a renewable nano-chemistry platform that combines vegetable-oil-based surfactants with microbubbles of water and ethanol to produce a microemulsion. This technology enables oil companies to lower production costs while generating green diesel fuel. Sylvatex aims to enhance the adoption of renewable energy sources globally, promoting a healthier environment. In addition to its fuel technology, the company is advancing lithium-ion battery processing applications and has established partnerships with national laboratories and the USDA to further its initiatives. With the increasing need for low-emission fuels, Sylvatex's scalable and cost-competitive solutions address the demand for cleaner alternatives in the petroleum market.
ClearFlame Engines, Inc. specializes in developing and manufacturing engines for heavy-duty applications, focusing on decarbonizing these engines to mitigate the reliance on diesel fuel. The company has created a patented system that allows for the production of high-performance engines at reduced costs, benefiting various sectors including marine, agriculture, transportation, power generation, rail, and construction. Founded in 2016 and based in Woodridge, Illinois, ClearFlame aims to lower operating costs while offering substantial fuel savings to its clients, addressing environmental challenges associated with traditional diesel engines.
Pow.bio provides intelligent fermentation services for industrial and synthetic biology, helping turn great ideas into profitable products. We combine continuous fermentation with advanced control methodology to quickly optimize your fermentation process and deliver high yields at low costs. Our scale runs from 1-100 liter capacity for bacteria, yeast, and filamentous fungi.
Beta Hatch grows insect protein for animal feed. Nutrient balanced fertilizer is a sterile by-product of their process. Beta Hatch knows bugs better than anyone- they use their expertise in entomology to grow the most efficient and nutritious insects. They are currently farming mealworms from their urban farm in Seattle. They believe in changing food systems. Their goal is to develop the technology and knowledge that will make insects the next commodity crop.
Ecovia Renewables Inc., founded in 2014 as a spin-out from the University of Michigan and based in Ann Arbor, specializes in developing bio-based ingredients and materials through a proprietary fermentation process utilizing renewable biomass. The company offers a variety of products, including the EcoSynth platform for biochemical and biofuel production, a suite of biopolymers designed as biodegradable alternatives to traditional polymers, and cellulosic biofuels derived from lignocellulosic biomass. Ecovia's biopolymers are versatile, finding applications in agriculture, such as soil additives for water retention, and in personal care products, serving as thickeners and super-absorbent materials. The company is committed to sustainable practices, aiming to provide high-performing, cost-effective biobased solutions for various industries.
Genoverde Biosciences develops cell wall technology to improve lignocellulosic energy crops and produce liquid fuels from plant sugars. The company was founded in 2015 and is headquartered in Raleigh, North Carolina.
Berkeley Yeast is a company that specializes in engineering yeast strains for the beer brewing industry. Founded by PhD graduates from Berkeley in 2016 and headquartered in Oakland, California, the company utilizes genome-editing technology to produce industrial brewer's yeast that serves as a substitute for hops in the brewing process. Berkeley Yeast focuses on enabling breweries to create beers that are both flavorful and sustainable, addressing the growing demand for innovative brewing solutions.
Algenesis is a material science and technology company focused on addressing the environmental challenges posed by fossil fuel-based products. It specializes in manufacturing renewable and biodegradable plastic materials derived from algae. The company develops biodegradable polyurethane foam products, including soft foams suitable for footwear and hard foams designed for surfboards. By creating these innovative materials, Algenesis aims to help businesses tackle the global plastic pollution crisis and promote more sustainable alternatives in various industries.
Farther Farms is a food technology company focused on creating shelf-stable alternatives to traditionally frozen foods. By employing a unique method that combines high pressure, dense carbon dioxide, and moderate temperatures, the company prevents spoilage in fruits and vegetables without the use of preservatives or genetic modification. This innovative approach not only enhances the shelf life of produce but also reduces costs, energy usage, and infrastructure demands throughout the food supply chain. Farther Farms emphasizes sustainability by sourcing organic, non-GMO crops locally, catering to consumers who prioritize the origins of their food and its environmental impact. The company's commitment to quality and technology ensures that their fresh produce remains both nutritious and environmentally friendly.
Sumatra Biorenewables, LLC is a startup that specializes in the production of trans‐3‐hexenedioic acid (3HDA), a novel biobased monomer manufactured from biologically‐produced muconic acid (MA). The introduction of 3HDA in polyamides or polyesters through copolymerization or compounding provides an ethylenic bond that enables the production of materials with tailored functional properties without altering the intrinsic nature of the polymeric material.
KnipBio, Inc. is a biotechnology company based in Lowell, Massachusetts, established in 2013. It focuses on developing sustainable and responsible feed solutions for the aquaculture industry, primarily through its innovative product, KnipBio Meal (KBM). This product serves as a protein-rich replacement for traditional fishmeal, combining the benefits of high-quality protein and carotenoids in a single, effective formulation. KnipBio employs naturally occurring microbe strains that convert abundant and low-cost feedstocks, such as ethanol and methanol, into nutritious single-cell protein. By addressing the challenges of animal nutrition, KnipBio aims to provide livestock owners with affordable and efficient feed alternatives, contributing to the evolution of sustainable aquaculture practices.
Cykloburn Technologies LLC develops combustion systems that convert poultry waste to energy. The company was founded in 2017 and is based in Baltimore, Maryland.
Sylvatex Inc. is a fuel technology company focused on developing innovative solutions for cleaner-burning fuels. Founded in 2007 and based in San Francisco, California, the company has created a renewable nano-chemistry platform that combines vegetable-oil-based surfactants with microbubbles of water and ethanol to produce a microemulsion. This technology enables oil companies to lower production costs while generating green diesel fuel. Sylvatex aims to enhance the adoption of renewable energy sources globally, promoting a healthier environment. In addition to its fuel technology, the company is advancing lithium-ion battery processing applications and has established partnerships with national laboratories and the USDA to further its initiatives. With the increasing need for low-emission fuels, Sylvatex's scalable and cost-competitive solutions address the demand for cleaner alternatives in the petroleum market.
Kalion, Inc. is an early-stage industrial biotechnology company based in Milton, Massachusetts, specializing in the development of glucaric acid and S-3 hydroxybutyrolactone (3-HBL) derived from renewable sources. Founded in 2010, the company employs green fermentation technology and advanced fermentation methods utilizing patented microbes to produce these valuable chemicals. Glucaric acid and 3-HBL are recognized as significant value-added chemicals from biomass, with applications in the industrial, pharmaceutical, and nutraceutical sectors. Kalion aims to transform the traditional chemical industry by offering cost-effective access to these compounds, addressing limitations related to their availability and pricing in multi-billion dollar markets.
KnipBio, Inc. is a biotechnology company based in Lowell, Massachusetts, established in 2013. It focuses on developing sustainable and responsible feed solutions for the aquaculture industry, primarily through its innovative product, KnipBio Meal (KBM). This product serves as a protein-rich replacement for traditional fishmeal, combining the benefits of high-quality protein and carotenoids in a single, effective formulation. KnipBio employs naturally occurring microbe strains that convert abundant and low-cost feedstocks, such as ethanol and methanol, into nutritious single-cell protein. By addressing the challenges of animal nutrition, KnipBio aims to provide livestock owners with affordable and efficient feed alternatives, contributing to the evolution of sustainable aquaculture practices.
Mesodyne's solution is a novel ultra-high energy density, multi-fuel, silent, compact power generator. Our generators convert fuel to electricity with heat and light as intermediaries: a small micro combustor heats a photonic crystal to incandescence and the resulting light is tailored to the bandgap of an infrared cell resulting in unprecedented high efficiencies.
Mesodyne's solution is a novel ultra-high energy density, multi-fuel, silent, compact power generator. Our generators convert fuel to electricity with heat and light as intermediaries: a small micro combustor heats a photonic crystal to incandescence and the resulting light is tailored to the bandgap of an infrared cell resulting in unprecedented high efficiencies.
Ecolectro makes materials that make clean fuels and chemicals. The company is commercializing a proprietary platform of novel polymers that are best in class, allowing its customers to produce devices that last longer and cost less. Ecolectro has defensible IP, state-of-the-art facilities, experienced personnel, and strong customer traction.
Mobius provides environmental solutions that convert waste streams into chemicals and materials. At Mobius, we're creating a world where There’s Wonder in Waste. We’re a mission-driven company focused on eliminating waste by leveraging industrial organic waste streams from agriculture, forestry, paper and biofuel & biorefining industries to create new materials and chemicals. Our first product is a proprietary, biodegradable polymer made from lignin, a natural material found in all grasses and trees that is produced as waste at a rate of over 50 million tons each year by the paper and biofuel industries. With this biopolymer, we are creating a bio-based, biodegradable plastic pellets for applications in horticulture, agriculture, food service packaging, and beyond.
ZymoChem, Inc. develops microbes and bioprocesses that enable production of chemicals from renewable sources, such as sugars. The company was founded in 2013 and is based in Emeryville, California.
Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.
EntoBio is focused on developing innovative solutions for natural decomposition, specifically through its flagship product, Liquid Termite™, which mimics the digestion process of termites to effectively dissolve tree stumps. The company synthesizes insect digestive enzymes that enhance the breakdown of cell walls and facilitate the treatment of challenging compounds. This technology aims to improve efficiency and sustainability across various applications, including vegetable oil, wood pulp, and biofuels. By reducing reliance on excessive energy and harmful chemicals, EntoBio enables producers to lower both operational and capital expenses while minimizing the production of hazardous byproducts.
Manus Bio Inc. recreates plant processes in microorganisms to produce natural ingredients through fermentation. The company’s microbial platform converts sugar sources into ingredients with applications, such as flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals, and agricultural chemicals. It merges metabolic engineering, protein engineering, and systems biology technologies to generate microbes that produce various plant-based ingredients. The company has a strategic partnership with BBGI Public Company Limited. Manus Bio Inc. was formerly known as Manus Biosynthesis, Inc. and changed its name to Manus Bio Inc. in June 2018. The company was founded in 2011 and is based in Cambridge, Massachusetts. It has manufacturing facilities in Cambridge, Massachusetts; and Augusta, Georgia.
ClearFlame Engines, Inc. specializes in developing and manufacturing engines for heavy-duty applications, focusing on decarbonizing these engines to mitigate the reliance on diesel fuel. The company has created a patented system that allows for the production of high-performance engines at reduced costs, benefiting various sectors including marine, agriculture, transportation, power generation, rail, and construction. Founded in 2016 and based in Woodridge, Illinois, ClearFlame aims to lower operating costs while offering substantial fuel savings to its clients, addressing environmental challenges associated with traditional diesel engines.
Solid Cell is a developer of stationary and portable solid-oxide fuel cell technologies for residential, commercial, industrial, and other critical off-grid applications. The Company’s headquarters are located in New York City, United States. Solid Cell’s principal product development and manufacturing center is located in Rochester, New York. Solid Cell also supports R&D activities at research institutions in the cities of Novosibirskand and Yekaterinburg, Russia, where the Company’s proprietary fuel cell technology was originally developed and where research continues on next generation fuel cell technologies. The Company’s European subsidiary is based in Dublin, Ireland, with further expansion in Europe planned in the near term. Solid Cell’s products provide clean energy using state-of-the-art fuel cell technology at commercially competitive costs. The Company has targeted several specific applications to satisfy a wide variety of global power requirements. Widespread use of Solid Cell’s fuel cells will reduce reliance on scarce natural resources like natural gas and oil.
Berkeley Yeast is a company that specializes in engineering yeast strains for the beer brewing industry. Founded by PhD graduates from Berkeley in 2016 and headquartered in Oakland, California, the company utilizes genome-editing technology to produce industrial brewer's yeast that serves as a substitute for hops in the brewing process. Berkeley Yeast focuses on enabling breweries to create beers that are both flavorful and sustainable, addressing the growing demand for innovative brewing solutions.
Developer of a photo-bioreactor system intended for algae cultivation. The company's system is composed of a metal support cage, a plastic bladder containing culture volume, and a sterile harvest apparatus for the continual collection of pre-concentrated culture, equipped with both pH and temperature control options, enabling production facilities to reduce their carbon footprint and maintain a low rate of water consumption, in order to minimize their impact on the local and global environment.
Visolis, a bioengineering company, develops carbon-negative and sustainable chemicals. Its systems approach integrates innovations in synthetic biology, chemical catalysis, and process scale-up to enable new bio-based manufacturing platforms. Visolis' bio-based process helps in achieving true carbon negative chemical synthesis. It began operation in 2012, with its headquarters in Berkeley in California.
Ecovia Renewables Inc., founded in 2014 as a spin-out from the University of Michigan and based in Ann Arbor, specializes in developing bio-based ingredients and materials through a proprietary fermentation process utilizing renewable biomass. The company offers a variety of products, including the EcoSynth platform for biochemical and biofuel production, a suite of biopolymers designed as biodegradable alternatives to traditional polymers, and cellulosic biofuels derived from lignocellulosic biomass. Ecovia's biopolymers are versatile, finding applications in agriculture, such as soil additives for water retention, and in personal care products, serving as thickeners and super-absorbent materials. The company is committed to sustainable practices, aiming to provide high-performing, cost-effective biobased solutions for various industries.
Developer of biomass conversion and hydrogen storage technology designed to study the storage of hydrogen on a novel material produced from silicon. The company's technology has the potential to eclipse all prior methods of hydrogen storage in terms of pressure, temperature, safety, cost, and convenience and converts biomass into energy, chemicals, fuel, and heat, enabling clients to access their technology to store biogas in porous silicon, smaller, lighter, and safer than battery storage.
Beta Hatch grows insect protein for animal feed. Nutrient balanced fertilizer is a sterile by-product of their process. Beta Hatch knows bugs better than anyone- they use their expertise in entomology to grow the most efficient and nutritious insects. They are currently farming mealworms from their urban farm in Seattle. They believe in changing food systems. Their goal is to develop the technology and knowledge that will make insects the next commodity crop.
Spero Energy, Inc. is an Indiana based company with the mission of developing cost competitive processes for the conversion of abundant non-food biomass to high value chemicals (HVCs) and renewable fuels. With its experienced and outstanding research and business team, Spero Energy has developed processes for a range of renewable chemicals targeting the flavor, fragrance, and pharmaceutical industries. Our initial lignin-derived flavor and fragrance chemicals target a multi-billion dollar market segment.
Solectrac designs and sells electric tractors that can replace the diesel vehicles that are widely used in the agriculture industry. This provides eco-friendly farming solutions. Compared to diesel tractors, electric tractors have several advantages: they are cleaner, are quieter, are more efficient, are less expensive to use, and provide their maximum torque and maximum power, regardless of the speed.
Xylome offers solutions that enable first generation biofuel manufacturers to use second generation technology solutions in their manufacturing process. It offers them with advisory, implementation, and support services. Xylome develops a range of non-conventional yeasts and yeast technology solutions for experimental assessments. Xylome was founded by Thomas W Jeffries in 2007. It is based in Madison, Wisconsin.
GlucanBio is a developer of innovative biomass conversion technology that focuses on producing furan derivatives such as furfural, HMF, DMF, THF, and FDCA. Originating from research at the University of Wisconsin and the Center for Biorenewable Chemicals at Iowa State, the company's processes fractionize biomass under mild conditions, resulting in cost-effective production of specialty and commodity chemicals. This approach not only enhances performance but also supports clients in transitioning toward sustainable practices. With a team that includes experts in catalysis and early-stage commercialization, GlucanBio is well-equipped to address technical challenges in the industry and capitalize on strong market opportunities.
Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.
Genoverde Biosciences develops cell wall technology to improve lignocellulosic energy crops and produce liquid fuels from plant sugars. The company was founded in 2015 and is headquartered in Raleigh, North Carolina.
Biorealize, Inc. designs and develops a reactor that heats, cools, agitates, and tracks microorganism growth in programmable media and culturing settings. Its product offers culturing and analytics solutions for fermentation, anaerobic and aerobic microbial culturing, animal cell culturing, and biofilm manufacturing. The company’s product is used in various applications, including fermented food and beverages, fashion and materials, cosmetics and personal care, and more. The company was incorporated in 2015 and is based in Philadelphia, Pennsylvania.
Bio Adhesive Alliance is a research and development organization focused on converting biomass and livestock waste management challenges in the agricultural sector into viable solutions for the construction industry. The team comprises scientists and industry experts who collaborate closely with academic institutions to address various aspects of the supply chain, including the collection, conversion, modification, characterization, and performance evaluation of biomass. The company specializes in producing bio-adhesives and bio-asphalt from sources such as swine manure, utilizing a liquefaction process that involves applying pressure and temperature, followed by filtration and post-processing. This innovative approach not only addresses waste management issues but also contributes to sustainable construction practices.
CinderBio produces ultra-stable enzymes made from amazing microbes that thrive in hot acidic volcanic waters around the globe. CinderBio's technologies access biodiversity unavailable to other enzyme producers and uses these to address applications and markets technically inaccessible to competitors. CinderBio has developed and field tested products for proteomics, clinical proteomics, and other laboratory applications and natural hot/acid enzymatic cleaning and sanitation products for the food and beverage sector. CinderBio's novel enzymatic capabilities open many industrial and scientific uses for enzymes that have been previously out of reach of enzymatic interventions.
Renuvix is a manufacturer of bio-based resins and polymers, catering to formulators in various industries including paints, coatings, composites, adhesives, cosmetics, and personal care products. Founded in 2013 and headquartered in Fargo, North Dakota, the company focuses on developing innovative resin and synthetic rubber solutions. Renuvix's products enable formulators to achieve lower volatile organic compound emissions in paints and coatings, while also enhancing the performance characteristics of thermosets through high cross-link density.
EntoBio is focused on developing innovative solutions for natural decomposition, specifically through its flagship product, Liquid Termite™, which mimics the digestion process of termites to effectively dissolve tree stumps. The company synthesizes insect digestive enzymes that enhance the breakdown of cell walls and facilitate the treatment of challenging compounds. This technology aims to improve efficiency and sustainability across various applications, including vegetable oil, wood pulp, and biofuels. By reducing reliance on excessive energy and harmful chemicals, EntoBio enables producers to lower both operational and capital expenses while minimizing the production of hazardous byproducts.
Ecolectro makes materials that make clean fuels and chemicals. The company is commercializing a proprietary platform of novel polymers that are best in class, allowing its customers to produce devices that last longer and cost less. Ecolectro has defensible IP, state-of-the-art facilities, experienced personnel, and strong customer traction.
SuperBrewed Food, a biotechnology company founded in 2011 and headquartered in New Castle, Delaware, focuses on developing innovative fermentation technologies for both human and animal probiotics. The company employs advanced synthetic biology and bioprocess development to create new probiotic solutions. Its technology portfolio includes MixoFerm, which facilitates the fermentation of carbohydrates with gas, and FlexFeedstock, allowing for adaptable biobased and gas feedstock inputs. Additionally, SuperBrewed Food utilizes Zero-CO2 Fermentation technology, which aims to produce CO2 in a sustainable manner, and employs liquid-liquid extraction methods for the fermentative production of various chemicals and fuels. Through these technologies, the company is positioned to contribute significantly to the fields of biochemistry and renewable resources.
BioMason is a biotechnology start-up focused on the building and construction industry, founded in 2012 and headquartered in Research Triangle Park, North Carolina. The company specializes in the production of biological cement-based masonry materials using natural microorganisms and chemical processes. Its product offerings include concrete masonry tiles suitable for various applications, biocement for dust control, and solutions for soil stabilization. BioMason aims to innovate the construction sector by providing sustainable alternatives that reduce environmental impact and enhance the efficiency of building practices.
Visolis, a bioengineering company, develops carbon-negative and sustainable chemicals. Its systems approach integrates innovations in synthetic biology, chemical catalysis, and process scale-up to enable new bio-based manufacturing platforms. Visolis' bio-based process helps in achieving true carbon negative chemical synthesis. It began operation in 2012, with its headquarters in Berkeley in California.
Operator of a self-erasing inkjet ink brand intended to make paper reusable without disposing and recycling. The company's ink absorbs and reacts with carbon dioxide present in the air which makes the ink colorless, enabling consumers to recycle and reuse the same paper multiple times.
Kalion, Inc. is an early-stage industrial biotechnology company based in Milton, Massachusetts, specializing in the development of glucaric acid and S-3 hydroxybutyrolactone (3-HBL) derived from renewable sources. Founded in 2010, the company employs green fermentation technology and advanced fermentation methods utilizing patented microbes to produce these valuable chemicals. Glucaric acid and 3-HBL are recognized as significant value-added chemicals from biomass, with applications in the industrial, pharmaceutical, and nutraceutical sectors. Kalion aims to transform the traditional chemical industry by offering cost-effective access to these compounds, addressing limitations related to their availability and pricing in multi-billion dollar markets.
Developer of a photo-bioreactor system intended for algae cultivation. The company's system is composed of a metal support cage, a plastic bladder containing culture volume, and a sterile harvest apparatus for the continual collection of pre-concentrated culture, equipped with both pH and temperature control options, enabling production facilities to reduce their carbon footprint and maintain a low rate of water consumption, in order to minimize their impact on the local and global environment.
KnipBio, Inc. is a biotechnology company based in Lowell, Massachusetts, established in 2013. It focuses on developing sustainable and responsible feed solutions for the aquaculture industry, primarily through its innovative product, KnipBio Meal (KBM). This product serves as a protein-rich replacement for traditional fishmeal, combining the benefits of high-quality protein and carotenoids in a single, effective formulation. KnipBio employs naturally occurring microbe strains that convert abundant and low-cost feedstocks, such as ethanol and methanol, into nutritious single-cell protein. By addressing the challenges of animal nutrition, KnipBio aims to provide livestock owners with affordable and efficient feed alternatives, contributing to the evolution of sustainable aquaculture practices.
Pivot Bio is a biotechnology company founded in 2010 and based in Emeryville, California, that focuses on enhancing crop nutrition through the use of engineered microbes. The company leverages its deep understanding of the plant microbiome, employing engineering principles and data science to map microbial dynamics and develop beneficial traits. Pivot Bio's proprietary ON Technology utilizes naturally occurring microbes to provide crops with essential nutrients, particularly nitrogen, which is crucial for growth. This innovative approach aims to replace synthetic nitrogen fertilizers, thereby reducing the environmental impact associated with conventional farming practices. By enhancing crops' ability to capture and metabolize atmospheric nitrogen, Pivot Bio seeks to lower farming costs, improve crop yields, and contribute to a sustainable agricultural future that benefits both the planet and food supply.
Industrial Microbes designs and builds microbes that produce better chemicals with lower costs and lower carbon emissions. We use greenhouse gases as the raw materials, including biogas, natural gas, and carbon dioxide. We scale our process with global chemical producers.
Xylome offers solutions that enable first generation biofuel manufacturers to use second generation technology solutions in their manufacturing process. It offers them with advisory, implementation, and support services. Xylome develops a range of non-conventional yeasts and yeast technology solutions for experimental assessments. Xylome was founded by Thomas W Jeffries in 2007. It is based in Madison, Wisconsin.
GlucanBio is a developer of innovative biomass conversion technology that focuses on producing furan derivatives such as furfural, HMF, DMF, THF, and FDCA. Originating from research at the University of Wisconsin and the Center for Biorenewable Chemicals at Iowa State, the company's processes fractionize biomass under mild conditions, resulting in cost-effective production of specialty and commodity chemicals. This approach not only enhances performance but also supports clients in transitioning toward sustainable practices. With a team that includes experts in catalysis and early-stage commercialization, GlucanBio is well-equipped to address technical challenges in the industry and capitalize on strong market opportunities.
Ecovia Renewables Inc., founded in 2014 as a spin-out from the University of Michigan and based in Ann Arbor, specializes in developing bio-based ingredients and materials through a proprietary fermentation process utilizing renewable biomass. The company offers a variety of products, including the EcoSynth platform for biochemical and biofuel production, a suite of biopolymers designed as biodegradable alternatives to traditional polymers, and cellulosic biofuels derived from lignocellulosic biomass. Ecovia's biopolymers are versatile, finding applications in agriculture, such as soil additives for water retention, and in personal care products, serving as thickeners and super-absorbent materials. The company is committed to sustainable practices, aiming to provide high-performing, cost-effective biobased solutions for various industries.
Altaeros Energies, Inc. specializes in the development and supply of airborne wind turbines that harness high-altitude winds for renewable energy generation. Founded in 2010 and located in Somerville, Massachusetts, the company’s innovative technology integrates aerospace engineering with wind turbine design to deliver a buoyant turbine solution. This technology aims to provide low-cost, abundant energy to various sectors, including rural and isolated communities, telecommunication, agriculture, and emergency response. Altaeros’ airborne turbines are designed for mobility and rapid deployment, making them suitable for remote, military, and offshore applications. The company has garnered funding from multiple organizations, including the U.S. Department of Agriculture and the National Science Foundation, and has received accolades such as the 2011 ConocoPhillips Energy Prize.
Nature's Fynd develops a protein production platform from extremophile organisms for consumer and industrial applications. The company was formerly known as Sustainable Bioproducts, Inc. Nature's Fynd was incorporated in 2016 and is headquartered in Chicago, Illinois with an additional office in Bozeman, Montana.
Spero Energy, Inc. is an Indiana based company with the mission of developing cost competitive processes for the conversion of abundant non-food biomass to high value chemicals (HVCs) and renewable fuels. With its experienced and outstanding research and business team, Spero Energy has developed processes for a range of renewable chemicals targeting the flavor, fragrance, and pharmaceutical industries. Our initial lignin-derived flavor and fragrance chemicals target a multi-billion dollar market segment.
Renuvix is a manufacturer of bio-based resins and polymers, catering to formulators in various industries including paints, coatings, composites, adhesives, cosmetics, and personal care products. Founded in 2013 and headquartered in Fargo, North Dakota, the company focuses on developing innovative resin and synthetic rubber solutions. Renuvix's products enable formulators to achieve lower volatile organic compound emissions in paints and coatings, while also enhancing the performance characteristics of thermosets through high cross-link density.
Greenyug is a technology development company focused on researching and commercializing the production of commodity chemicals, specialty chemicals, polymers, and fuels derived from renewable sources. The company engages in all facets of technology development, guiding projects from initial concepts at the laboratory scale through to pilot testing and eventual commercialization. By leveraging renewable materials, Greenyug aims to provide sustainable alternatives in the chemical industry, catering to clients seeking innovative solutions in chemical production.
Cell-Free Bioinnovations
Grant in 2014
Cell-Free Bioinnovations uses proprietary networks of enzymes (not microbes) to make food/feed ingredients and energy products. Cell-Free Bioinnovations is an early-stage company developing products from its platform technology that uses networks of enzymes (instead of microbes) to catalyze high-yield reactions. CFB's advances will permit the cost-effective production of energy products and nutraceuticals from plant-derived carbohydrates (including renewable, non-food biomass) rather than hydrocarbons.
Benson Hill is an agricultural technology company focused on crop improvement, particularly in soy protein innovation. By leveraging its proprietary CropOS™ platform, the company integrates machine learning, genomic data, and traditional breeding techniques to streamline the development of healthier and more sustainable food products. Benson Hill emphasizes unlocking the natural genetic diversity of plants to empower innovators in creating flavorful and nutritious ingredients. The company operates a Crop Accelerator for rapid prototyping and is developing a diverse seed portfolio that includes protein ingredients, aquaculture, specialty animal feed, and vegetable oils. Its revenue is generated from both proprietary and non-proprietary product categories, reflecting its commitment to advancing agricultural innovation.
Bio Adhesive Alliance is a research and development organization focused on converting biomass and livestock waste management challenges in the agricultural sector into viable solutions for the construction industry. The team comprises scientists and industry experts who collaborate closely with academic institutions to address various aspects of the supply chain, including the collection, conversion, modification, characterization, and performance evaluation of biomass. The company specializes in producing bio-adhesives and bio-asphalt from sources such as swine manure, utilizing a liquefaction process that involves applying pressure and temperature, followed by filtration and post-processing. This innovative approach not only addresses waste management issues but also contributes to sustainable construction practices.
BioMason is a biotechnology start-up focused on the building and construction industry, founded in 2012 and headquartered in Research Triangle Park, North Carolina. The company specializes in the production of biological cement-based masonry materials using natural microorganisms and chemical processes. Its product offerings include concrete masonry tiles suitable for various applications, biocement for dust control, and solutions for soil stabilization. BioMason aims to innovate the construction sector by providing sustainable alternatives that reduce environmental impact and enhance the efficiency of building practices.
Dioxide Materials is focused on advancing sustainable technology by developing systems that recycle waste carbon dioxide into fuels and chemicals, thereby addressing climate change and reducing carbon emissions. The company offers a range of products, including Sustainion membranes and ionomers, which serve as catalysts and electrolytes in various electrochemical applications. These include carbon dioxide and water electrolyzers that generate renewable syngas and systems that convert air, water, and renewable energy into renewable gasoline. By providing efficient solutions for the production of clean energy, Dioxide Materials aims to facilitate the transition to a low-carbon economy and promote the utilization of waste carbon dioxide in the creation of valuable products.
Benson Hill is an agricultural technology company focused on crop improvement, particularly in soy protein innovation. By leveraging its proprietary CropOS™ platform, the company integrates machine learning, genomic data, and traditional breeding techniques to streamline the development of healthier and more sustainable food products. Benson Hill emphasizes unlocking the natural genetic diversity of plants to empower innovators in creating flavorful and nutritious ingredients. The company operates a Crop Accelerator for rapid prototyping and is developing a diverse seed portfolio that includes protein ingredients, aquaculture, specialty animal feed, and vegetable oils. Its revenue is generated from both proprietary and non-proprietary product categories, reflecting its commitment to advancing agricultural innovation.
Manus Bio Inc. recreates plant processes in microorganisms to produce natural ingredients through fermentation. The company’s microbial platform converts sugar sources into ingredients with applications, such as flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals, and agricultural chemicals. It merges metabolic engineering, protein engineering, and systems biology technologies to generate microbes that produce various plant-based ingredients. The company has a strategic partnership with BBGI Public Company Limited. Manus Bio Inc. was formerly known as Manus Biosynthesis, Inc. and changed its name to Manus Bio Inc. in June 2018. The company was founded in 2011 and is based in Cambridge, Massachusetts. It has manufacturing facilities in Cambridge, Massachusetts; and Augusta, Georgia.
Ambiharv has established cutting–edge research and technology in harvesting energy from the environment. This unique technology requires significantly less power than existing products. The significance of this research has been recognized by a National Science Foundation grant (Phase I). Ambiharv continues to develop and apply this advanced technology to MEMS commercial applications in all industries.
Mango Materials, Inc., founded in 2010 and based in Albany, California, specializes in producing biodegradable biopolymers from waste biogas, specifically methane. The company focuses on converting polyhydroxyalkanoate into a range of eco-friendly plastic products, offering a sustainable alternative to conventional oil-based plastics. By leveraging waste materials, Mango Materials aims to provide manufacturers with economically viable options for creating sustainable products. Their innovative approach positions them as a competitive player in the bioplastics market, emphasizing both environmental responsibility and economic feasibility.
Calysta, Inc. is a biotechnology company focused on developing and manufacturing protein ingredients derived from sustainable sources. Based in Menlo Park, California, with additional locations in Houston, London, Stavanger, and Singapore, Calysta provides nutritional feeds and health products for fish and livestock, as well as chemicals used in various end products such as fibers, plastics, and building materials. The company also produces biofuels through innovative processes utilizing methane as a feedstock. Founded in 2011, Calysta was previously known as Calysta Energy before rebranding in 2014. Its technologies, including biological gas-to-liquids and gas-to-chemicals processes, aim to address global food security and meet the rising demand for sustainable protein in the aquaculture industry. The company has formed a strategic partnership with Bluestar Adisseo Company to enhance its market offerings.
Nature's Fynd develops a protein production platform from extremophile organisms for consumer and industrial applications. The company was formerly known as Sustainable Bioproducts, Inc. Nature's Fynd was incorporated in 2016 and is headquartered in Chicago, Illinois with an additional office in Bozeman, Montana.
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