Newlin Investment Company

SpIntellx, Inc. is a computational and systems pathology company based in Pittsburgh, Pennsylvania, that specializes in spatial intelligence software for analyzing pathology tissue sections, particularly in cancer diagnosis. The company offers several products, including SpIntellx, which processes image data from various imaging platforms, and HistoMapr, a computational guide designed to assist pathologists. Additionally, TumorMapr analyzes the spatial interactions of biomarkers within whole slide images using multiplexed fluorescence. Founded in 2017 by a team of pathologists, computer scientists, and biotechnologists, SpIntellx aims to enhance the accuracy and efficiency of pathologists while providing predictive data to improve patient outcomes.

C2Sense, Inc. specializes in the development of chemiresistive gas sensors aimed at applications in food and agriculture. The company’s sensors detect gases such as ethylene and biogenic amines at very low concentrations, facilitating the monitoring of fruit ripeness and the freshness of meat, fish, and poultry throughout the supply chain. By providing accurate data, C2Sense enables growers, shippers, distributors, retailers, and consumers to make informed decisions that help reduce food waste. Founded in 2013 as a spinout from MIT, C2Sense employs nanotechnology and advanced chemical engineering techniques to create miniaturized mobile sensing solutions. In addition to food-related applications, the company’s technology addresses challenges in rapid medical diagnostics, product authentication, environmental monitoring, and safety across various sectors. Based in Cambridge, Massachusetts, C2Sense is committed to promoting a healthier and safer world through its innovative sensing technology.

Carmell Therapeutics Corporation, founded in 2007 and based in Pittsburgh, Pennsylvania, specializes in the production of plasma-based biologically-active plastic medical devices designed for the treatment of bone and connective tissue injuries. The company utilizes proprietary technology developed in collaboration with Carnegie Mellon University and Allegheny General Hospital to manufacture these sterile, off-the-shelf products. Their offerings include REPAIR bone putty, which is used to fill bone defects, and a surgical scaffold that facilitates the healing of injured tendons and ligaments. These products are engineered to promote tissue healing by leveraging the body’s own growth and regenerative factors, ensuring favorable mechanical properties that align with the repaired tissue. Carmell Therapeutics primarily targets the sports medicine market, aiming to enhance clinical outcomes for patients with connective tissue injuries.

Sharp Edge Labs, Inc. is a biotechnology company based in Pittsburgh, Pennsylvania, specializing in the development of biosensors aimed at enhancing drug discovery and understanding cellular biology. The company creates Fluorogenic Activating Modules (FAMs) that enable precise detection of cellular trafficking, which is essential for high-throughput screening and subsequent analysis. Additionally, Sharp Edge Labs produces single-chain antibody fragments that activate specially designed fluorescent dyes and assays for receptor internalization. Their research focuses on addressing monogenic diseases, trafficking defects, and initiatives driven by patient needs. Key programs include efforts to correct the trafficking defect in deltaF508 CFTR to improve lung function, as well as developing trafficking assays for lysosomal storage disorders and Parkinson's disease. The company was initially known as Sharp Edge Technologies, Inc. and has been operational since its incorporation in 2010.

Machine Translation answers the need of today’s global business for high volume and high velocity content localization and enterprise translation. Safaba provides Enterprise Machine Translation solutions to the world’s leading global enterprises.

Liquid X is a company specializing in the development of innovative metallic inks that enable the printing of functional components for various electronic devices. Their inks, which contain actual metal atoms rather than nanoparticles or metal flakes, offer superior properties such as high conductivity, thin and precise features, and excellent adhesion. This unique formulation allows for low-temperature processing and short production times, making it possible to use a wide range of substrates, including paper, gauze, and flexible plastics. Liquid X collaborates with manufacturers in the electronics industry to create applications such as sensors, heating elements, and smart textiles. The versatility of their inks supports various deposition methods, including inkjet, flexography, and gravure, positioning Liquid X as a key player in the emerging market for advanced electronic materials.

Carmell Therapeutics Corporation, founded in 2007 and based in Pittsburgh, Pennsylvania, specializes in the production of plasma-based biologically-active plastic medical devices designed for the treatment of bone and connective tissue injuries. The company utilizes proprietary technology developed in collaboration with Carnegie Mellon University and Allegheny General Hospital to manufacture these sterile, off-the-shelf products. Their offerings include REPAIR bone putty, which is used to fill bone defects, and a surgical scaffold that facilitates the healing of injured tendons and ligaments. These products are engineered to promote tissue healing by leveraging the body’s own growth and regenerative factors, ensuring favorable mechanical properties that align with the repaired tissue. Carmell Therapeutics primarily targets the sports medicine market, aiming to enhance clinical outcomes for patients with connective tissue injuries.

Plextronics specializes in printed electronics. The company's focus is on organic light emitting diode (OLED) displays and lighting, specifically conductive inks and associated process technologies. Plextronic's technology will enable the mass production of these printed devices and therefore lower the cost.