Khosla Ventures
Khosla Ventures is a California-based venture capital firm founded in 2004 by Vinod Khosla. It provides capital and strategic guidance to startups across stages, focusing on technology-driven companies in areas such as artificial intelligence, climate and sustainability, enterprise software and services, fintech, digital health, medical technology and diagnostics, therapeutics, consumer products, and frontier technologies. The firm backs bold ventures with the potential to disrupt markets and improve lives, supporting companies from early to growth stages and working closely with entrepreneurs to apply science, technology and innovative business models. While primarily investing in North American technology companies, Khosla Ventures pursues opportunities globally and emphasizes experimentation and impact alongside financial returns. The firm also maintains related impact initiatives that support entrepreneurs addressing socio-economic challenges in emerging markets.
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Past deals in Chemical
Resource Chemical
Venture Round in 2025
ReSource Chemical is a company based in Berkeley, California, focused on developing high-performance plastics derived from carbon dioxide. The company utilizes a proprietary bio-based platform to create chemicals that enable the production of environmentally friendly plastics with superior physical properties compared to traditional fossil fuel-based plastics. By converting CO2 into these innovative materials, ReSource Chemical aims to provide sustainable alternatives that do not contribute to environmental pollution.
Yoneda Labs
Seed Round in 2024
Yoneda Labs is a developer of AI-based software designed to assist chemists in optimizing reaction parameters essential for the synthesis of drugs and materials. The platform enables users to determine critical factors such as temperature, concentration, and catalyst, thereby enhancing the efficiency and speed of chemical laboratory processes. By leveraging advanced artificial intelligence, Yoneda Labs aims to streamline the development of chemical reactions, ultimately facilitating faster innovation in the pharmaceutical and material sciences industries.
Menten AI
Seed Round in 2020
Menten AI, established in 2018 with headquarters in San Francisco and a satellite office in Toronto, is an early-stage biotech company specializing in drug discovery. It leverages machine learning and quantum computing to develop novel protein-based drugs and enzymes for pharmaceutical and chemical industries. Menten AI's core offering is a proprietary protein design algorithm tailored for current and near-term quantum computers, enabling efficient exploration of protein structures for therapeutic applications, such as oncology and neurodegeneration, and industrial enzyme development.
20n
Seed Round in 2015
20n is a biotechnology company that focuses on engineering microbes through advanced algorithms to produce valuable chemicals for therapeutic and industrial applications. Their innovative technology has successfully demonstrated the ability to create bacteria capable of synthesizing Paracetamol, a widely used pain reliever, representing a significant breakthrough in bioproduction methods. Additionally, 20n is developing an open-source platform that allows users to predict DNA edits and design custom fermentation organisms, facilitating the discovery of new molecules and more efficient production processes. The company's data mining capabilities further enhance their potential to identify and produce a wide spectrum of biologically-derived chemicals, positioning them at the forefront of synthetic biology and biomanufacturing.
Coskata
Debt Financing in 2013
Coskata, Inc. is a renewable energy company focused on producing liquid fuels through innovative biological processes. The company specializes in the development of technologies for converting various input materials, including natural gas, wood, and industrial waste, into cellulosic ethanol. Utilizing proprietary microorganisms and advanced bioreactor designs, Coskata aims to deliver solutions that enhance economic viability, environmental sustainability, and national security. Its capabilities in molecular biology and process engineering enable the effective transformation of diverse resources into valuable fuels and chemicals, positioning Coskata as a leader in the renewable energy sector.
Segetis
Series C in 2012
Segetis, Inc. is a green chemistry company based in Golden Valley, Minnesota, specializing in the development, production, and commercialization of renewable polymers. Founded in 2006, Segetis focuses on a platform of binary monomers derived from renewable feedstocks, including non-food agricultural and forestry materials. The company's innovative technology supports the production of a range of industrial bioproducts such as bio-plastics, surfactants, plasticizers, adhesives, and coalescent solvents, catering to specialty chemical applications. Segetis's chemistries create opportunities for product enablement and synergies across various industries, including those involved in the processing of starch, sugar crops, wood, cellulose, and paper pulp, as well as the chemical processing of vegetable oils and the manufacturing of biodiesel and linear alpha-olefins.
Virdia
Debt Financing in 2012
Virdia, formerly known as HCL CleanTech, is a prominent developer specializing in the conversion of lignocellulosic biomass into cellulosic sugars and lignin for applications in the renewable chemicals, bio-energy, and nutrition sectors. Utilizing its proprietary CASE™ process, the company transforms a diverse range of feedstocks, including wood, energy crops, and agricultural residues, into highly refined sugars and lignin. This innovative low-temperature process achieves high yields of sugars from biomass while maintaining a minimal environmental impact through the near complete recycling of acids and solvents used during production. Virdia is guided by an experienced management team with extensive backgrounds in corn processing, chemicals, and biochemicals.
Coskata
Series D in 2011
Coskata, Inc. is a renewable energy company focused on producing liquid fuels through innovative biological processes. The company specializes in the development of technologies for converting various input materials, including natural gas, wood, and industrial waste, into cellulosic ethanol. Utilizing proprietary microorganisms and advanced bioreactor designs, Coskata aims to deliver solutions that enhance economic viability, environmental sustainability, and national security. Its capabilities in molecular biology and process engineering enable the effective transformation of diverse resources into valuable fuels and chemicals, positioning Coskata as a leader in the renewable energy sector.
LS9
Series D in 2010
LS9, known as the Renewable Petroleum Company, is a privately-held industrial biotechnology firm based in South San Francisco, California. The company focuses on the development and production of patent-pending UltraClean fuels and sustainable chemicals utilizing synthetic biology. By harnessing advanced industrial synthetic biology techniques, LS9 aims to create renewable petroleum biofuels that serve as eco-friendly alternatives to traditional fossil fuels.
Coskata
Series D in 2010
Coskata, Inc. is a renewable energy company focused on producing liquid fuels through innovative biological processes. The company specializes in the development of technologies for converting various input materials, including natural gas, wood, and industrial waste, into cellulosic ethanol. Utilizing proprietary microorganisms and advanced bioreactor designs, Coskata aims to deliver solutions that enhance economic viability, environmental sustainability, and national security. Its capabilities in molecular biology and process engineering enable the effective transformation of diverse resources into valuable fuels and chemicals, positioning Coskata as a leader in the renewable energy sector.
Segetis
Series B in 2010
Segetis, Inc. is a green chemistry company based in Golden Valley, Minnesota, specializing in the development, production, and commercialization of renewable polymers. Founded in 2006, Segetis focuses on a platform of binary monomers derived from renewable feedstocks, including non-food agricultural and forestry materials. The company's innovative technology supports the production of a range of industrial bioproducts such as bio-plastics, surfactants, plasticizers, adhesives, and coalescent solvents, catering to specialty chemical applications. Segetis's chemistries create opportunities for product enablement and synergies across various industries, including those involved in the processing of starch, sugar crops, wood, cellulose, and paper pulp, as well as the chemical processing of vegetable oils and the manufacturing of biodiesel and linear alpha-olefins.
LS9
Series C in 2009
LS9, known as the Renewable Petroleum Company, is a privately-held industrial biotechnology firm based in South San Francisco, California. The company focuses on the development and production of patent-pending UltraClean fuels and sustainable chemicals utilizing synthetic biology. By harnessing advanced industrial synthetic biology techniques, LS9 aims to create renewable petroleum biofuels that serve as eco-friendly alternatives to traditional fossil fuels.
Virdia
Series A in 2009
Virdia, formerly known as HCL CleanTech, is a prominent developer specializing in the conversion of lignocellulosic biomass into cellulosic sugars and lignin for applications in the renewable chemicals, bio-energy, and nutrition sectors. Utilizing its proprietary CASE™ process, the company transforms a diverse range of feedstocks, including wood, energy crops, and agricultural residues, into highly refined sugars and lignin. This innovative low-temperature process achieves high yields of sugars from biomass while maintaining a minimal environmental impact through the near complete recycling of acids and solvents used during production. Virdia is guided by an experienced management team with extensive backgrounds in corn processing, chemicals, and biochemicals.
Draths
Series C in 2009
Draths Corporation is a pioneering chemical company dedicated to producing biobased materials for various applications, including nylons, plastics, paints, and resins. By leveraging proprietary technologies that combine metabolic engineering, synthetic biology, and chemical synthesis, the company transforms renewable feedstocks into primary chemical ingredients. Its product offerings include shikimic acid, aminoshikimic acid, quinic acid, butanetriol, phloroglucinol, caprolactam, vanillin, myo-inositol, dehydroshikimic acid, gallic acid, pyrogallol, and tetrahydroxybenzene. Draths focuses on environmentally friendly processes that significantly reduce carbon footprints while maintaining cost-effectiveness, thereby providing sustainable alternatives to traditional petroleum-based chemicals used in everyday products.
Coskata
Series C in 2008
Coskata, Inc. is a renewable energy company focused on producing liquid fuels through innovative biological processes. The company specializes in the development of technologies for converting various input materials, including natural gas, wood, and industrial waste, into cellulosic ethanol. Utilizing proprietary microorganisms and advanced bioreactor designs, Coskata aims to deliver solutions that enhance economic viability, environmental sustainability, and national security. Its capabilities in molecular biology and process engineering enable the effective transformation of diverse resources into valuable fuels and chemicals, positioning Coskata as a leader in the renewable energy sector.
Coskata
Series B in 2008
Coskata, Inc. is a renewable energy company focused on producing liquid fuels through innovative biological processes. The company specializes in the development of technologies for converting various input materials, including natural gas, wood, and industrial waste, into cellulosic ethanol. Utilizing proprietary microorganisms and advanced bioreactor designs, Coskata aims to deliver solutions that enhance economic viability, environmental sustainability, and national security. Its capabilities in molecular biology and process engineering enable the effective transformation of diverse resources into valuable fuels and chemicals, positioning Coskata as a leader in the renewable energy sector.
Nanostellar
Series E in 2008
Nanostellar, Inc. develops precious-metals containing materials for the automotive and stationary power industries, enabling these industries to meet stringent diesel emissions-control requirements mandated in Europe, the U.S. and Asia.
The company delivers nano-engineered catalyst materials that reduce exhaust emissions and increase effectiveness of precious metals in these catalysts by 25%-30%. Nanostellar's Rational Catalyst Design methodology combines computation materials science, novel synthesis and chemical engineering to aid in the rapid development of new materials.
Draths
Series B in 2007
Draths Corporation is a pioneering chemical company dedicated to producing biobased materials for various applications, including nylons, plastics, paints, and resins. By leveraging proprietary technologies that combine metabolic engineering, synthetic biology, and chemical synthesis, the company transforms renewable feedstocks into primary chemical ingredients. Its product offerings include shikimic acid, aminoshikimic acid, quinic acid, butanetriol, phloroglucinol, caprolactam, vanillin, myo-inositol, dehydroshikimic acid, gallic acid, pyrogallol, and tetrahydroxybenzene. Draths focuses on environmentally friendly processes that significantly reduce carbon footprints while maintaining cost-effectiveness, thereby providing sustainable alternatives to traditional petroleum-based chemicals used in everyday products.
LS9
Series B in 2007
LS9, known as the Renewable Petroleum Company, is a privately-held industrial biotechnology firm based in South San Francisco, California. The company focuses on the development and production of patent-pending UltraClean fuels and sustainable chemicals utilizing synthetic biology. By harnessing advanced industrial synthetic biology techniques, LS9 aims to create renewable petroleum biofuels that serve as eco-friendly alternatives to traditional fossil fuels.
Segetis
Series A in 2007
Segetis, Inc. is a green chemistry company based in Golden Valley, Minnesota, specializing in the development, production, and commercialization of renewable polymers. Founded in 2006, Segetis focuses on a platform of binary monomers derived from renewable feedstocks, including non-food agricultural and forestry materials. The company's innovative technology supports the production of a range of industrial bioproducts such as bio-plastics, surfactants, plasticizers, adhesives, and coalescent solvents, catering to specialty chemical applications. Segetis's chemistries create opportunities for product enablement and synergies across various industries, including those involved in the processing of starch, sugar crops, wood, cellulose, and paper pulp, as well as the chemical processing of vegetable oils and the manufacturing of biodiesel and linear alpha-olefins.
LS9
Series A in 2007
LS9, known as the Renewable Petroleum Company, is a privately-held industrial biotechnology firm based in South San Francisco, California. The company focuses on the development and production of patent-pending UltraClean fuels and sustainable chemicals utilizing synthetic biology. By harnessing advanced industrial synthetic biology techniques, LS9 aims to create renewable petroleum biofuels that serve as eco-friendly alternatives to traditional fossil fuels.
Nanostellar
Series A in 2004
Nanostellar, Inc. develops precious-metals containing materials for the automotive and stationary power industries, enabling these industries to meet stringent diesel emissions-control requirements mandated in Europe, the U.S. and Asia.
The company delivers nano-engineered catalyst materials that reduce exhaust emissions and increase effectiveness of precious metals in these catalysts by 25%-30%. Nanostellar's Rational Catalyst Design methodology combines computation materials science, novel synthesis and chemical engineering to aid in the rapid development of new materials.
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