Maryland Innovation Initiative (MII)

Developer of RNA therapies designed to inoculate trees, vines, and bushes against diseases, eliminating the need for genetic modification. The company's RNA therapy includes introducing a virus like RNA bacterial inside the tree veins to destroy viral and fungal pathogens, enabling food growers to ensure abundant and diverse food supplies while protecting natural resources.

Haystack Solutions helps corporations, education, and workforce development organizations to identify cybersecurity talent. Haystack Solutions offers a Cyber Aptitude and Talent Assessment test to predict the capability of an individual to succeed in cybersecurity and focuses on recruiting and retention of candidates, enabling clients to hire deserving cybersecurity talent.

Developer of a geothermal technology designed to fix the global energy crisis. The company's technology provides global access to clean and economically competitive geothermal energy with the help of an underground heat harvesting system, it aggregates a series of state-of-the-art oil and gas and power production technologies and above-ground binary power production technologies and then integrates them into a sophisticated geothermal power production system that will solve the fatal flaws of past and present experimental enhanced geothermal system and advanced geothermal systems development efforts, enabling clients to use clean, renewable, baseload power.

Kubanda Cryotherapy specializes in providing minimally invasive, non-surgical treatments for lumps, bumps, and cancers in pets. The company has developed a custom-designed cryosystem that includes a cryoprobe and a gas-control module, allowing for precise temperature modulation. This innovative system employs freezing cycles that have been proven effective in shrinking and killing tumors. By offering a point-of-care solution, Kubanda Cryotherapy enables veterinarians and pet owners to access quality care for their pets without the need for surgical interventions.

Geminus Therapeutics is developing best-in-class Artemisinin (ART714) for treating leukemia.

ML4Cyber specializes in developing automated solutions for analyzing software code to identify vulnerabilities in commercial technology. The company's platform employs machine learning and data science techniques to enhance the accuracy of vulnerability detection, reducing both false positives and false negatives. By providing detailed cybersecurity reports that include risk categorization, ML4Cyber aims to deliver a user-friendly experience for its clients, facilitating better decision-making in cybersecurity management.

Capsulomics, LLC is a biotechnology company focused on developing and manufacturing DNA tests for the early detection of upper gastrointestinal cancers and related diseases. Established in 2018 and based in Halethorpe, Maryland, the company specializes in diagnosing esophageal cancer and its precancerous condition, Barrett’s esophagus. By leveraging advancements in diagnostics and medical technology, Capsulomics aims to improve early detection and intervention for gastrointestinal cancers, contributing to better patient outcomes.

PreSquared is a healthcare technology company that develops predictive analytics for caregivers and patients.

Synteris is developing first-in-class precursor powders for 3D printing of high-temperature ceramics.

BLOCKsyncop is focused on creating a non-invasive, real-time clinical monitoring device aimed at anesthesiologists. The technology is designed to offer objective measurements that quantify the controlled delivery and effectiveness of neural blocks for pain management. By providing healthcare professionals with this tool, BLOCKsyncop seeks to reduce the incidence of failed neural blocks, minimize anesthetic toxicity, and optimize the overall analgesic needs of patients.

Empower Therapeutics is a digital therapeutics company focused on noninvasive neuromodulation of pain sensitivity through functional targeting. The company is developing a platform that utilizes reliable EEG-based biomarkers to assist clinicians in assessing and adjusting pain sensitivity for chronic pain management. By offering innovative solutions, Empower Therapeutics aims to help individuals with chronic pain reduce their reliance on opioids and other analgesics, ultimately improving their quality of life.

Evincis Bio is a company solving therapeutic challenges in Urology with innovative medical technologies.

TEDCO was created by the Maryland State Legislature in 1998 to facilitate the transfer and commercialization of technology from Maryland’s research universities and federal labs into the marketplace and to assist in the creation and growth of technology-based businesses in all regions of the State. TEDCO is an independent organization that strives to be Maryland’s lead source for entrepreneurial business assistance and seed funding for the development of startup companies in Maryland’s innovation economy. In Maryland and beyond, TEDCO is a resource of mentoring, funding and networking for entrepreneurs and start-ups that need guidance as they bring innovative concepts to market. TEDCO is more than an early stage funding resource. It is the hub of Maryland’s entrepreneurial network where startups find mentors, organizational assistance, facilities for daily operations, and a roadmap for success.

Sonoval LLC, based in Baltimore, Maryland, specializes in developing innovative protein-based therapies for cancer treatment, focusing on T-cell lymphomas and solid tumors. The company's lead drug, SON-211, targets tumor cells by binding to specific receptors, delivering a toxic payload that destroys cancerous cells. In addition to directly attacking tumors, SON-211 works to eliminate immune system suppressors, thereby enhancing the body’s own anticancer defenses. Incorporated in 2017, Sonoval aims to provide effective immunotherapy solutions to address various forms of cancer, offering new hope for patients facing these challenging diseases.

The Renalert System, located in Baltimore, provides early detection of the onset of acute kidney injury through novel analysis of a patient’s urine output, blood pressure and oxygenation status. (JHU)

Mind-X Corp. specializes in designing and developing interfaces for spatial computing applications by integrating neurotechnology, augmented reality, and artificial intelligence. Founded in 2017 by Geoffrey Ling and Julia Brown, the company focuses on creating a framework that combines brain-computer interfaces with advanced AI capabilities. Headquartered in Bethesda, Maryland, Mind-X aims to enhance user interaction with technology through innovative software solutions that leverage cutting-edge advancements in neuroscience and computing.

OncoSTING LLC, founded in 2018 and based in Baltimore, Maryland, specializes in developing innovative therapies for bladder cancer. The company's approach integrates the established efficacy of BCG immunotherapy with a novel delivery system for potent STING agonists, which aims to enhance treatment effectiveness while minimizing the adverse effects typically associated with traditional BCG therapy. By focusing on this combination, OncoSTING seeks to provide a more effective and safer treatment option for patients suffering from bladder cancer.

“ActiveCharge™,” located in Baltimore, is a system that can effectively harvest wasted vibrational/kinematic energy and convert it to electrical energy for battery free sensor operation in wind powered turbines. (UMBC)

Magic Blue is a company develops skin care products using Methylene blue.

The Substrate Cage™ line of analytical tools enables researches to make real-time measurements of microbial growth and/or enzyme activity in combination with insoluble substrates. The original Substrate Cage™ design was created to measure the rate of bacterial lignocellulose degradation, but has subsequently been expanded to other insoluble bio-polymers.The Substrate Cage™ is easy to use and is compatible with common laboratory equipment, but has the advantage of facilitating rapid measurements with no lag time in data acquisition.