Armistice Capital

Adocia is a clinical-stage biotechnology company based in Lyons, France, founded in 2005 and known for its focus on tissue regeneration. The company specializes in developing formulations of approved therapeutic proteins and peptides aimed at treating diabetes and other metabolic diseases. Adocia has created a proprietary technology platform called Biochaperone, which enhances the effectiveness of these therapeutic proteins. Its clinical pipeline includes products such as Biochaperone Lispro, Biochaperone Combo, and Biochaperone Glucagon, while its pre-clinical pipeline features BioChaperone LisPram, BioChaperone Glargine GLP-1, and BioChaperone Glucagon GLP1. Additionally, Adocia holds a patent portfolio that primarily addresses chronic wound healing, insulin therapy, and monoclonal antibodies.

ProMIS Neurosciences, Inc. is a development-stage biotechnology company based in Toronto, Canada, focused on developing precision therapeutic solutions for neurodegenerative diseases, primarily Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD). Established in 2004, the company employs a proprietary target discovery engine that integrates thermodynamic and computational techniques to identify disease-specific epitopes on misfolded proteins. Its lead product candidates include PMN310, PMN350, and PMN330, which are monoclonal antibodies targeting toxic forms of amyloid beta oligomers and prion-like proteins associated with AD. Additionally, ProMIS is developing treatments targeting the neurotoxic tau protein in AD and proteins linked to ALS and PD. The company collaborates with BC Neuroimmunology to advance proprietary diagnostic assays and blood-based tests for Alzheimer’s disease, enhancing early detection and treatment efficacy. Formerly known as Amorfix Life Sciences Ltd., ProMIS Neurosciences has rebranded itself to reflect its focus on neurological therapeutics.

Assembly Biosciences, Inc. is a clinical-stage biotechnology company based in South San Francisco, California, focused on developing innovative oral therapeutics for the treatment of hepatitis B virus (HBV) infection and novel oral biotherapeutics targeting microbiome-related diseases. The company is advancing a pipeline of drug candidates aimed at improving cure rates for chronic HBV by inhibiting various steps in the viral lifecycle. Its microbiome program features a comprehensive platform for strain identification, isolation, and growth under Good Manufacturing Practices, complemented by a patented delivery system known as GEMICEL, which facilitates targeted oral delivery of therapies to the lower gastrointestinal tract. Key product candidates include ABI-H0731, currently in Phase 2a clinical trials for HBV, and additional candidates under development for conditions such as Crohn’s disease, irritable bowel syndrome, and oncology. Assembly also collaborates with Allergan Pharmaceuticals and Door Pharmaceuticals to enhance its research and development efforts. The company was formerly known as Ventrus Biosciences, Inc. before rebranding in June 2014.

Corvus Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Burlingame, California, specializing in the development of immuno-oncology therapies. The company focuses on creating first-in-class agents that modulate the immune system to treat cancer and other diseases. Its lead product candidate, Ciforadenant (CPI-444), is an oral small molecule antagonist of the A2A receptor currently undergoing Phase Ib/2 clinical trials. Additionally, Corvus is developing CPI-006, an anti-CD73 monoclonal antibody in Phase I/Ib trials aimed at inhibiting adenosine production and stimulating immune cells, as well as a Phase I trial for COVID-19. Another candidate, CPI-818, is a small molecule inhibitor targeting interleukin-2-inducible T-cell kinase, also in Phase I/Ib trials. The company has established a strategic collaboration with Angel Pharmaceuticals to further advance its pipeline of investigational medicines. Founded in 2014, Corvus Pharmaceuticals aims to contribute significantly to the field of immunotherapy and improve patient outcomes in various diseases.

Zura Bio is a clinical-stage biotechnology company dedicated to developing innovative therapies for immune and inflammatory disorders. It focuses on advancing its pipeline of treatments through phase 2 development programs, including ZB-168 and torudokimab, which target autoimmune illnesses. ZB-168 is an anti-IL7R inhibitor designed to address disorders linked to IL7 and TSLP biological pathways, building on encouraging phase 1b data related to type 1 diabetes. Torudokimab, a human-affinity monoclonal antibody, is in phase 2 clinical development and works by neutralizing IL33. Through these initiatives, Zura Bio aims to create effective therapeutic options for patients suffering from complex immune-related conditions.

ARTARA THERAPEUTICS is a clinical-stage healthcare company focused on developing transformative therapies for individuals with rare and specialty diseases. Its lead program, TARA-002, is an investigational cell therapy designed to treat lymphatic malformations and non-muscle invasive bladder cancer. Additionally, the company is advancing intravenous choline chloride, an investigational phospholipid substrate replacement therapy aimed at addressing intestinal failure-associated liver disease. Based in New York, ARTARA THERAPEUTICS is dedicated to providing innovative solutions for patients with limited treatment options, leveraging a team that values creativity and diverse perspectives to expedite the development of its therapies.

CervoMed is a clinical-stage company focused on developing therapeutic treatments for neurodegenerative diseases, particularly in the early stages of these illnesses. The firm specializes in creating drugs aimed at addressing conditions affecting the central nervous system, with a primary emphasis on Alzheimer's disease. CervoMed's innovative approach includes a drug that promotes functional recovery in patients experiencing acute neurological injuries, thereby enhancing the ability of healthcare professionals to effectively manage brain diseases and improve episodic memory functions in affected individuals.

Greenidge is a 106MW natural gas power plant and blockchain mining facility. Greenidge Generation has been transformed into a power plant for the twenty-first century. In January 2020, Greenidge launched the first phase of a data center for blockchain mining. Greenidge was established in 1937 and is based in Dresden, New York, United States.

Tenaya Therapeutics is a preclinical stage biotechnology company based in South San Francisco, California, specializing in the development of innovative therapies for heart disease, particularly heart failure. Established in 2016, the company employs a multipronged approach to address the fundamental cellular pathologies associated with cardiac muscle disease. Tenaya Therapeutics advances its product candidates through three primary platforms: a cellular regeneration platform that reprograms cardiac fibroblasts into cardiomyocytes using proprietary transcription factors, a gene therapy platform for targeted delivery of therapeutic payloads to cardiac fibroblasts, and a precision medicine platform that offers personalized treatment strategies. Through its research, the company aims to enable physicians to regenerate heart tissue and tackle various forms of cardiomyopathies effectively.

Outlook Therapeutics, Inc. is a late clinical-stage biopharmaceutical company dedicated to the development and commercialization of monoclonal antibodies for ophthalmic conditions. The company's primary focus is on its lead product candidate, ONS-5010, a proprietary ophthalmic formulation of bevacizumab, currently undergoing Phase-III clinical trials aimed at treating wet age-related macular degeneration and other retinal diseases. Outlook Therapeutics has established collaboration and licensing agreements with several international partners, including IPCA Laboratories Limited and Laboratorios Liomont, S.A. de C.V. Originally incorporated as Oncobiologics, Inc. in 2010, the company rebranded to Outlook Therapeutics, Inc. in November 2018 and is headquartered in Cranbury, New Jersey.

Aligos Therapeutics, Inc. is a clinical-stage biopharmaceutical company founded in 2018 and based in South San Francisco, California. The company is dedicated to developing innovative therapeutics to meet unmet medical needs in viral and liver diseases. Its primary focus is on chronic hepatitis B (CHB), with a robust pipeline that includes several drug candidates: ALG-010133, a synthetic oligonucleotide currently in Phase I clinical trials; ALG-000184, a capsid assembly modulator; ALG-020572, another oligonucleotide; and ALG-125097, an siRNA drug candidate. Additionally, Aligos is advancing ALG-055009, a small molecule THR-ß agonist aimed at treating non-alcoholic steatohepatitis (NASH). Aligos aims to leverage its expertise in liver diseases and viral infections to develop targeted antiviral therapies and establish itself as a leader in this therapeutic area.

Mithra Pharmaceuticals SA develops, manufactures, and markets innovative therapeutics focused on women's health, particularly in the areas of contraception, menopause, and hormone-dependent cancers. The company's key development candidates include Estelle, a fifth-generation oral contraceptive that has completed phase III clinical trials, and Donesta, a next-generation hormone therapy for menopausal symptoms currently in phase III trials. Additionally, Mithra is advancing several other products, such as Myring, a contraceptive vaginal ring, and Zoreline, a biodegradable implant for treating prostate and breast cancers. Established in 1999 and headquartered in Liège, Belgium, Mithra Pharmaceuticals operates in multiple regions, including Belgium, Europe, and beyond, and offers a comprehensive spectrum of services through its CDMO, catering to research, development, and specialist manufacturing needs.

COMPASS Pathways is a mental health care company based in Cheshire, United Kingdom, with operations in the United States. The company is focused on developing innovative therapies for treatment-resistant depression (TRD) using its proprietary psilocybin formulation, COMP360. Currently undergoing Phase IIb clinical trials, COMP360 aims to provide a new treatment option for patients who have not responded to traditional depression therapies. COMPASS Pathways emphasizes the combination of psilocybin-assisted therapy with psychological support to enhance treatment efficacy. The company is committed to addressing the significant unmet needs in mental health care by advancing evidence-based solutions for those suffering from mental health challenges.

Lyra Therapeutics, Inc. is a clinical-stage therapeutics company dedicated to developing and commercializing innovative drug and delivery solutions for the localized treatment of ear, nose, and throat diseases. The company utilizes its proprietary XTreo technology platform, which allows for the precise and sustained delivery of medications directly to affected tissues through a single administration. Its lead product candidates, LYR-210 and LYR-220, are bioresorbable polymeric matrices designed for non-invasive in-office procedures, providing up to six months of continuous drug therapy for chronic rhinosinusitis. The active ingredient in these products is mometasone furoate, known for its established efficacy and safety profile in various FDA-approved medications. Founded in 2005 and headquartered in Watertown, Massachusetts, Lyra Therapeutics aims to improve treatment outcomes for patients suffering from ENT diseases.

Spruce Biosciences, Inc. is a biopharmaceutical company based in Daly City, California, specializing in the development and commercialization of innovative therapies for rare endocrine disorders. Founded in 2014, the company is primarily focused on its lead product candidate, tildacerfont, which is undergoing clinical trials for adult and pediatric patients with classic congenital adrenal hyperplasia (CAH). Tildacerfont is being developed as a non-steroidal therapy aimed at improving disease management and reducing reliance on steroids for affected patients. Additionally, the company is exploring the use of tildacerfont for females with polycystic ovary syndrome. With a commitment to addressing the unmet medical needs of patients with rare endocrine conditions, Spruce Biosciences aims to enhance the quality of life for those who have been historically underserved by existing treatment options. The company also has a partnership with Eli Lilly and Company to explore further pharmaceutical applications of its compounds.

Karyopharm Therapeutics Inc. is a clinical-stage pharmaceutical company based in Newton, Massachusetts, focused on the discovery and development of innovative drug therapies for cancer and other significant diseases. The company specializes in small molecule selective inhibitors of nuclear export (SINE) compounds, targeting the nuclear export protein exportin 1. Its lead product, XPOVIO, is approved in the U.S. for treating multiple myeloma in various settings. Karyopharm is advancing several clinical trials, including BOSTON and STORM for multiple myeloma, SADAL for diffuse large B-cell lymphoma, and SEAL for liposarcoma. Additionally, it is exploring the treatment of endometrial cancer through the SIENDO trial and glioblastoma multiforme in the KING trial. The company maintains collaborations to facilitate clinical trials and research efforts, including projects related to COVID-19. Karyopharm continues to develop various investigational programs aimed at expanding its therapeutic portfolio.

Abeona Therapeutics is a clinical-stage biopharmaceutical company focused on developing gene and cell therapies for life-threatening rare genetic diseases. Its lead programs include EB-101, an autologous, gene-corrected cell therapy for recessive dystrophic epidermolysis bullosa; ABO-102, an adeno-associated virus-based gene therapy for Sanfilippo syndrome type A; and ABO-101, an AAV-based gene therapy for Sanfilippo syndrome type B. The company also develops therapies for Batten disease, cystic fibrosis, and genetic eye disorders. Additionally, Abeona Therapeutics is advancing the AIM Vector Platform, which includes over 100 next-generation AAV capsids for delivering gene therapies to various organs. The company operates a manufacturing facility producing therapies and vectors for preclinical and clinical studies.

Provention Bio, Inc. is a clinical-stage biopharmaceutical company based in Oldwick, New Jersey, focused on developing and commercializing innovative therapeutics aimed at intercepting and preventing immune-mediated diseases. The company's pipeline includes several product candidates, such as PRV-031 teplizumab, which is in Phase III trials for the interception of type 1 diabetes, and PRV-6527, an oral CSF-1R inhibitor currently in Phase IIa trials for Crohn's disease. Additional candidates include PRV-3279 for lupus, PRV-101, a vaccine for coxsackie virus B infections, and PRV-015, an anti-IL-15 monoclonal antibody in Phase IIb trials for non-responsive celiac disease. Provention Bio's approach aims to reduce the burden of chronic autoimmune and inflammatory diseases through early intervention. The company was incorporated in 2016 and is committed to leveraging its expertise in translational medicine and immunology to efficiently develop and partner with clinical-stage assets.

Eyenovia, Inc. is a clinical-stage ophthalmic biopharmaceutical company based in New York, specializing in the development of innovative microdose therapeutics through its proprietary piezo-print delivery technology called the Optejet. Founded in 2014, Eyenovia aims to transform the delivery of ophthalmic therapies by providing high-precision, targeted administration of medications, which has the potential to replace traditional eye droppers and enhance safety, tolerability, and patient compliance. The company is advancing several product candidates, including MicroLine for presbyopia, MicroProst for chronic angle closure glaucoma and other conditions, MicroStat for mydriasis, MicroTears for red eye and itch relief, and MicroPine for progressive myopia. Eyenovia focuses on developing treatments for ophthalmic diseases where no FDA-approved therapies currently exist, contributing to its goal of improving patient care in the field of eye health.

Xeris Biopharma Holdings is a specialty pharmaceutical company focused on developing and commercializing innovative therapies for patients in endocrinology, neurology, and gastroenterology. The company utilizes its proprietary formulation technologies, XeriSol and XeriJect, to create ready-to-use, liquid-stable injectables that facilitate subcutaneous and intramuscular delivery of various therapeutic agents. Xeris offers three commercially available products: Gvoke, a liquid glucagon for severe hypoglycemia; Keveyis, the first FDA-approved treatment for primary periodic paralysis; and Recorlev, approved for endogenous hypercortisolemia in adults with Cushing's Syndrome. Xeris Biopharma's formulation platforms aim to improve patient and caregiver ease of use by eliminating reconstitution, ensuring long-term stability at room temperature, and reducing injection volume, thereby enhancing healthcare delivery and potentially lowering costs for the healthcare system. The company is also advancing a pipeline of development programs to expand its product offerings.

ERYTECH Pharma S.A. is a clinical-stage biopharmaceutical company based in Lyon, France, founded in 2004. The company specializes in the development of red blood cell-based therapeutics aimed at treating cancer and orphan diseases. Its lead product candidate, eryaspase, is currently undergoing Phase III clinical trials for second-line pancreatic cancer and Phase II trials for triple-negative breast cancer. Additionally, ERYTECH is developing erymethionase, a preclinical candidate targeting methionine-dependent cancers, which consists of methionine-gamma-lyase encapsulated in red blood cells. The company collaborates with research institutions such as the Fox Chase Cancer Center and Queen’s University of Canada to enhance the preclinical development of its products for conditions like homocystinuria and arginase-1 deficiency, respectively. Through its innovative approach to encapsulating therapeutic molecules, ERYTECH Pharma aims to improve the efficacy and safety of its treatments.

Mauna Kea Technologies SA is a medical device company headquartered in Paris, France, specializing in the development and marketing of advanced imaging technology for the diagnosis and treatment of cancers and other diseases. Founded in 2000, the company focuses on real-time in vivo microscopic visualization to eliminate uncertainties in medical diagnoses. Its primary product, Cellvizio, is a multidisciplinary confocal laser endomicroscopy platform that enables physicians to obtain cellular-level images of tissues during standard medical procedures. Cellvizio has received regulatory approval for use in the United States and over 40 other countries, supporting a wide range of applications. Mauna Kea Technologies generates revenue through the sale of Cellvizio devices, accessories, and related services, while emphasizing its role in enhancing diagnostic accuracy and informing therapeutic decisions.

Kiora Pharmaceuticals is a clinical-stage specialty pharmaceutical company focused on developing and commercializing innovative treatments for ophthalmic diseases. The company's lead product, KIO-301, is a molecular photoswitch designed to restore light perception and improve vision in patients suffering from inherited and age-related retinal degeneration, including conditions such as retinitis pigmentosa, choroideremia, and Stargardt disease. Kiora is also developing KIO-101, a next-generation non-steroidal, immuno-modulatory small molecule inhibitor targeting dihydroorotate dehydrogenase, aimed at minimizing off-target side effects while effectively managing immune responses. Additionally, Kiora is working on KIO-201, a modified form of hyaluronic acid intended to promote corneal wound healing. Through these products, Kiora Pharmaceuticals seeks to address significant unmet medical needs in the ophthalmic space.

Medigus Ltd. is a medical device company based in Omer, Israel, focused on developing, manufacturing, and marketing minimally invasive endo-surgical tools and direct visualization technology. Founded in 1999, the company is known for its flagship product, the Medigus Ultrasonic Surgical Endostapler (MUSE) system, which provides a single-use device for the incisionless treatment of gastroesophageal reflux disease (GERD). This innovative system integrates a miniaturized video camera, a surgical stapler, and ultrasonic alignment technology, enabling gastroenterologists and surgeons to perform endoluminal procedures that eliminate the need for traditional open or laparoscopic surgery. In addition to its GERD treatment solutions, Medigus designs and manufactures advanced endoscopy systems and micro video cameras for various medical and industrial applications, leveraging its proprietary technologies to support a wide range of endoscopic procedures.

Addex Therapeutics Ltd is a clinical-stage biopharmaceutical company based in Geneva, Switzerland, specializing in the discovery, development, and commercialization of novel orally available small-molecule drugs, particularly allosteric modulators targeting central nervous system (CNS) disorders. The company's leading programs include Dipraglurant, aimed at treating levodopa-induced dyskinesia in Parkinson's disease and dystonia, ADX71149 for epilepsy and other undisclosed CNS disorders, and a GABAB positive allosteric modulator for addiction. Addex Therapeutics emphasizes the advantages of allosteric modulators over traditional non-allosteric molecules, as they may provide improved therapeutic solutions. The company also has a collaboration agreement with Janssen Pharmaceuticals Inc. to develop mGluR2PAM compounds for therapeutic use. Founded in 2002, Addex Therapeutics was formerly known as Addex Pharmaceuticals Ltd and rebranded in March 2012.