Angel Physicians Fund

Alphyn Biologics is a life science company that develops proprietary drug therapy for treating skin diseases. Alphyn's initial target indication are skin infections caused by deadly drug-resistant MRSA bacteria based on their proprietary Multi-Target Therapeutic (MTT) plant-derived technology platform.

PanTher Therapeutics, Inc. is a biotechnology company focused on developing innovative drug-delivery treatments for cancer. Based in Cambridge, Massachusetts, the company has created a novel delivery method that targets tumors directly, which aims to reduce the toxicity and debilitating side effects commonly associated with traditional chemotherapy administered through intravenous or oral routes. By enhancing the amount of drug that reaches the tumor site, PanTher's technology seeks to improve therapeutic efficacy while potentially lowering healthcare costs associated with adverse outcomes. The company's initial focus is on pancreatic cancer, a particularly aggressive disease characterized by severe symptoms due to tumor invasion of vital organs. Established in 2014, PanTher Therapeutics is committed to advancing its proprietary delivery platform to address the challenges of treating life-threatening cancers.

Based in the Boston biotech and medtech hub, Elucid Bioimaging is focused on improving the accuracy, experience, & cost-effectiveness of cardiovascular diagnostic imaging by leveraging machine learning. Elucid's main product, vascuCAP, is the first-ever, FDA-cleared, histologically-validated software for evaluating plaque vulnerability from a single CTA to inform risk of event (heart attack or stroke) & treatment selection. Additionally, Elucid works with pharmaceutical companies, providers, and research organizations to provide quantitative image analysis services.

S4 Medical Corp is a medical device company based in Cleveland, Ohio, founded in 2017. The company specializes in developing innovative solutions for catheter ablation treatment of atrial fibrillation. Its flagship product, the eSolution device, is designed to reduce complications to the esophagus during these procedures, enhancing patient safety and outcomes. S4 Medical focuses on addressing the challenges associated with cardiac procedures by providing effective protective measures during catheter ablation.

Moray Medical specializes in developing advanced robotic delivery systems for structural heart therapies, particularly focusing on edge-to-edge valve leaflet repair for patients with leaky heart valves. The company aims to enhance the quality of life for individuals suffering from this condition by offering innovative solutions that enable cardiologists to perform mitral valve clip therapies more safely and cost-effectively. Moray Medical's technology features a compact, reusable fluid-drive system that allows precise movement of flexible delivery catheters, facilitated by a digital interface akin to operating a computer cursor. This approach streamlines the treatment process, making life-saving heart valve therapies more accessible to a greater number of patients.

Foldax, Inc. is a company based in Salt Lake City, Utah, specializing in the design and manufacture of heart valves for individuals suffering from aortic, mitral, or tricuspid valve disease. Founded in 2013, Foldax focuses on developing synthetic heart valves that aim to be non-thrombogenic, providing a cost-effective alternative to existing artificial or tissue valves. The company offers its Tria biopolymer heart valves, which can be implanted either percutaneously or surgically, thereby addressing critical needs in cardiac care.