Engine Ventures

Developer of a cement decarbonizing technology designed to reduce emissions and co-produce green hydrogen. The company's technology uses clean renewable energy and an electrochemical process that eliminates carbon dioxide emissions without changing the properties or chemistry of the cement, enabling builders to contribute towards the shared goal of a sustainable and renewable future.

Mantel is focused on developing innovative carbon capture technology aimed at reducing carbon dioxide emissions and achieving net-negative emissions. The company's method captures CO2 before it can enter the atmosphere, utilizing low energy processes to enhance efficiency. Designed for integration within boilers, kilns, and furnaces, Mantel's technology leverages biomass waste and residue to facilitate significant carbon removal. This approach addresses sustainability challenges while utilizing liquid-phase chemistry applicable across various sectors, including industrial heat, steel, and chemicals. By enabling clients to lower their costs associated with carbon capture and storage, Mantel plays a crucial role in the transition towards a more sustainable future.

Foundation Alloy leverage advanced materials technology to design novel alloys optimized for additive manufacturing.

Operator of a feedstock processing company intended to power the creation of sustainable chemicals, materials, fuels, and foods. The company uses fungal fermentation to upcycle waste used in food manufacturing and produce cost-competitive essential goods for multiple industries, enabling the food industry to reduce its carbon footprint.

Seaspire Skincare specializes in the development and manufacturing of multifunctional colorants and active ingredients derived from oceanic biodiversity. The company focuses on creating innovative solutions to address chronic and cosmetic hair and skin conditions while aiming to replace harmful components in traditional sunscreens. One of its key products features the biomolecule Xanthochrome, which provides enhanced protection against a wider spectrum of ultraviolet radiation compared to existing physical and chemical filters. This technology is designed for preventative skincare, promoting a healthier approach that minimizes adverse effects on both human and marine health. Through its sustainable and less toxic formulations, Seaspire Skincare contributes to advancing the skincare industry towards safer and environmentally friendly practices.

Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Quaise is an energy company pioneering millimeter wave drilling technology to access deep geothermal energy. Quaise is developing and commercializing novel millimeter wave drilling systems to harness geothermal energy around the globe, overcoming the geographic constraints limiting this energy source today.

Celestial AI, founded in 2020 by David Lazovsky, Michelle Tomasko, and Preet Virk, specializes in artificial intelligence-based optical neuromorphic photonics and computing solutions. The company, headquartered in San Jose, California, focuses on developing optical neural network systems that enhance deep learning and machine learning applications. Its innovative approach aims to leverage photonics technology to improve the efficiency and performance of AI computations, positioning Celestial AI as a key player in the evolving landscape of AI-driven technologies.

Resonant Link LLC manufactures and develops wireless charging solutions by leveraging coil technology. Its products include Resonant Link’s multi-layer self-resonant structure (MSRS). It serves robot, drone, and electric vehicles industries throughout the world. The company was founded in 2017 and is based in Shelburne, Vermont.

Sync Computing Corp. specializes in the development of optimization processing units (OPUs) that address complex combinatorial optimization challenges across various sectors, including telecommunications, pharmaceuticals, finance, and logistics. Founded in 2019 and headquartered in Cambridge, Massachusetts, the company offers innovative solutions that integrate advanced algorithms into hardware, enhancing the ability of organizations to tackle significant optimization issues. By leveraging its technology, Sync Computing aims to improve operational efficiency and effectiveness in industries that heavily utilize machine learning and optimization techniques.

Cellino Biotech, Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2017. It specializes in intracellular delivery lasers and nanotechnology specifically for gene editing applications. The company has developed an AI-guided laser editing platform that automates the generation of personalized, autologous cell therapies, significantly reducing the development time of engineered cells from years to weeks. By integrating advanced tools from optics, biology, and computation, Cellino makes stem cell differentiation a digital process, allowing healthcare providers to efficiently produce functionally mature cells at scale. This innovative approach aims to enhance the accessibility of life-saving medicines for patients.

Commonwealth Fusion Systems LLC is a research company focused on developing fusion energy as a sustainable solution to combat climate change. Established in 2017 and based in Cambridge, Massachusetts, the company utilizes advanced rare-earth barium copper oxide superconductor technology to create energy through fusion. Commonwealth Fusion Systems combines decades of government-funded fusion research with innovative superconducting magnet technology to expedite the commercialization of fusion energy. The company emerged from the Massachusetts Institute of Technology and collaborates closely with MIT’s Plasma Science and Fusion Center, leveraging extensive research to enhance its development efforts. By designing and building fusion machines, Commonwealth Fusion aims to provide limitless and clean energy, contributing to the global transition toward sustainable energy sources.

Analytical Space, Inc. operates a satellite relay network that facilitates the rapid transmission of data from imaging satellites to the ground. Founded in 2016 and based in Cambridge, Massachusetts, the company focuses on creating an in-orbit communication infrastructure that enhances the accessibility and immediacy of satellite data. By offering services that ensure backward compatibility, high throughput, and low latency, Analytical Space aims to provide satellite operators with real-time insights into global developments.

Via Separations, Inc. is a company based in Somerville, Massachusetts, focused on developing membrane-based products for the efficient separation of industrial liquids in complex environments. Incorporated in 2016, the company utilizes advanced materials technology that significantly reduces energy consumption—reportedly using ten times less energy than traditional separation methods. Via Separations specializes in industrial decarbonization through its innovative membrane filtration systems, improving selectivity between nano filtration solutes while enhancing temperature stability, solvent resistance, and oxidizer tolerance. This enables manufacturing facilities to increase productivity while minimizing their energy usage.

Kytopen Corp. is a biotechnology company based in Cambridge, Massachusetts, focused on advancing cell therapy through its innovative Flowfect technology. Established in 2017, Kytopen specializes in non-viral delivery systems for molecules into challenging immune cells that are typically hard to transfect. The company utilizes a combination of microfluidics and automation to streamline the delivery process, making it faster, more efficient, and cost-effective. By employing a unique platform that integrates continuous fluid flow with electric fields, Kytopen enables researchers to produce high-quality engineered cells in a matter of minutes while preserving their health and functionality. This approach supports the discovery of novel biological insights and the development of affordable cell and gene therapies.

Lilac Solutions has developed a new ion exchange technology to address the challenges faced by lithium producers. Lilac's technology cuts capital and operating costs, accelerates project startup, boosts lithium recovery, and unlocks new resources. Their process is modular and can be ramped up quickly through pilot and commercial projects. Lilac is a mining technology company and is building partnerships with brine developers and operators around the world.

Form Energy, Inc. specializes in developing long-duration energy storage systems aimed at facilitating the transition from fossil fuels to renewable energy sources. The company focuses on creating low-cost battery solutions capable of storing electricity generated from wind and solar power for extended periods, thereby enhancing the reliability of the electric grid. Its core technology, which includes an innovative iron-air battery, allows for energy dispatch over multiple days, significantly improving the viability of renewable energy as a consistent power source. Founded in 2017 and headquartered in Somerville, Massachusetts, Form Energy also offers Formware, a software tool designed for capacity expansion with advanced optimization capabilities. The company's mission revolves around enabling deep decarbonization of the electric system, ultimately contributing to a more sustainable energy future. Form Energy has garnered support from various investors, including Breakthrough Energy Ventures and MIT’s The Engine.

Emvolon is a technology company focused on developing a platform that facilitates the distributed production of chemicals from wasted resources, particularly natural gas at flare sites. By converting this wasted gas into usable chemicals, Emvolon addresses a variety of industrial applications and offers carbon-negative fuel alternatives. The company's innovative approach reimagines conventional diesel engines as miniature chemical reactors, allowing for efficient and localized chemical production. This method eliminates the need for large refineries and chemical plants, making it economically viable for smaller production facilities. Emvolon's technology aims to provide communities with the necessary raw materials while promoting sustainability and reducing waste.

Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Syzygy Plasmonics is a developer of a photocatalytic reactor designed for fuel cell vehicles and small-scale industrial applications.The company's reactor is powered by light and operates at over 1,000°F lower temperature than conventional chemical reactor technology that helps in reducing maintenance costs and is able to start or stop production near instantaneously, enabling fuel cell vehicle companies to produce ultra-low-cost hydrogen gas on-site at customer locations.

VEIR is focused on advancing electricity transmission through the development of high-temperature superconductors and innovative cooling solutions. The company has created a passive evaporative cryogenic cooling technology that significantly enhances cooling efficiency, delivering 20 times more cooling power per kilogram of nitrogen flow compared to traditional mechanical subcooling methods. By utilizing commercial superconducting tape, VEIR's technology facilitates power delivery at transmission levels over distribution-scale infrastructure without resistive losses. This approach allows clients to streamline permitting processes and create economically viable electric transmission lines, thereby addressing the challenges associated with cooling high-temperature superconductors.

Cellino Biotech, Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2017. It specializes in intracellular delivery lasers and nanotechnology specifically for gene editing applications. The company has developed an AI-guided laser editing platform that automates the generation of personalized, autologous cell therapies, significantly reducing the development time of engineered cells from years to weeks. By integrating advanced tools from optics, biology, and computation, Cellino makes stem cell differentiation a digital process, allowing healthcare providers to efficiently produce functionally mature cells at scale. This innovative approach aims to enhance the accessibility of life-saving medicines for patients.

Celestial AI, founded in 2020 by David Lazovsky, Michelle Tomasko, and Preet Virk, specializes in artificial intelligence-based optical neuromorphic photonics and computing solutions. The company, headquartered in San Jose, California, focuses on developing optical neural network systems that enhance deep learning and machine learning applications. Its innovative approach aims to leverage photonics technology to improve the efficiency and performance of AI computations, positioning Celestial AI as a key player in the evolving landscape of AI-driven technologies.

Boston Metal is a technology company specializing in industrial-scale metal production solutions through its innovative Molten Oxide Electrolysis (MOE) process. Founded in 2012 as a spin-out from MIT, the company focuses on providing the metals industry with an efficient, cost-effective, and environmentally friendly method for producing various metals and alloys from diverse feedstocks. The MOE technology employs an electrolytic cell to convert raw iron ore into ferroalloys, which are essential for manufacturing specific grades of steel. Since its inception, Boston Metal has successfully scaled its technology by 1,000 times, producing thousands of kilograms of metal. The company is headquartered in Woburn, Massachusetts, where it operates its industrial development center.

Routable AI Inc., founded in 2019 and based in Cambridge, Massachusetts, specializes in fleet management software designed for on-demand transportation services, including shuttles and buses. The company aims to address the evolving mobility landscape, targeting the high-capacity mobility-as-a-service market, which is projected to be worth $30 billion. By leveraging advanced AI and patent-pending routing algorithms developed from extensive research at MIT, Routable AI provides a platform that significantly enhances operational efficiency for fleet operators. This technology enables dynamic routing of transportation services, leading to reductions in fleet sizes by up to 80% while offering a cost-effective and convenient alternative for commuters and corporations alike.

Zapata Computing is a quantum software company that offers computing solutions for industrial and commercial use. It provides hardware-agnostic solutions for simulation, optimization, and machine learning applications in chemistry, finance, logistics, pharmaceuticals, engineering, and materials. Zapata Computing is a spun out of Harvard University launched by a group of Harvard scientists, including Alán Aspuru-Guzik. The company was founded in 2017 and is headquartered in Boston, Massachusetts.

Form Energy, Inc. specializes in developing long-duration energy storage systems aimed at facilitating the transition from fossil fuels to renewable energy sources. The company focuses on creating low-cost battery solutions capable of storing electricity generated from wind and solar power for extended periods, thereby enhancing the reliability of the electric grid. Its core technology, which includes an innovative iron-air battery, allows for energy dispatch over multiple days, significantly improving the viability of renewable energy as a consistent power source. Founded in 2017 and headquartered in Somerville, Massachusetts, Form Energy also offers Formware, a software tool designed for capacity expansion with advanced optimization capabilities. The company's mission revolves around enabling deep decarbonization of the electric system, ultimately contributing to a more sustainable energy future. Form Energy has garnered support from various investors, including Breakthrough Energy Ventures and MIT’s The Engine.

WoHo Systems, Inc. constructs buildings spaces and structures. It offers WoHo Systems which are made up of a series of discrete foundational components which can be scaled and configured to span residential and commercial buildings, such as multifamily housing, hotels, dormitories, labs, and offices. It also provides suite and tower used in residential and commercial buildings. The company was incorporated in 2018 and is based in Cambridge, Massachusetts with additional offices in Madrid, Spain.

Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Quaise is an energy company pioneering millimeter wave drilling technology to access deep geothermal energy. Quaise is developing and commercializing novel millimeter wave drilling systems to harness geothermal energy around the globe, overcoming the geographic constraints limiting this energy source today.

Commonwealth Fusion Systems LLC is a research company focused on developing fusion energy as a sustainable solution to combat climate change. Established in 2017 and based in Cambridge, Massachusetts, the company utilizes advanced rare-earth barium copper oxide superconductor technology to create energy through fusion. Commonwealth Fusion Systems combines decades of government-funded fusion research with innovative superconducting magnet technology to expedite the commercialization of fusion energy. The company emerged from the Massachusetts Institute of Technology and collaborates closely with MIT’s Plasma Science and Fusion Center, leveraging extensive research to enhance its development efforts. By designing and building fusion machines, Commonwealth Fusion aims to provide limitless and clean energy, contributing to the global transition toward sustainable energy sources.

Biobot Analytics, Inc. is a wastewater epidemiology company based in Cambridge, Massachusetts, founded in 2017. The company specializes in transforming sewer systems into public health observatories through innovative technology that analyzes wastewater samples. By deploying proprietary sampling devices and spatial analytics, Biobot measures various health threats, including infectious disease outbreaks, antibiotic resistance, and fluctuations in drug consumption. One of its key initiatives is the Opioid Consumption Monitoring Program, which assesses opioid usage by analyzing sewage to provide estimates of drug consumption in urban areas. This approach creates a health database that operates independently of traditional hospital reporting systems, enabling rapid adaptation to emerging public health challenges while minimizing societal biases in healthcare access.

Rise Robotics, based in Somerville, Massachusetts, designs and manufactures innovative robotic components inspired by biological systems. Founded in 2011, the company aims to advance the robotics industry with a focus on creating powerful wearable ExoSUITS. Among its notable products is the Cyclone Muscle, a lightweight electric linear actuator that transforms rotary motion into linear force, enhancing performance in various applications by bridging the gap between force, speed, and control. Additionally, Rise Robotics developed the Bacon Robotic Air Compressor, which disrupts traditional handheld air compressors through the use of their Cyclone Linear Drive technology. This innovation supports a range of robotic functionalities, reflecting the company's commitment to empowering human capabilities through advanced robotics.

Lilac Solutions has developed a new ion exchange technology to address the challenges faced by lithium producers. Lilac's technology cuts capital and operating costs, accelerates project startup, boosts lithium recovery, and unlocks new resources. Their process is modular and can be ramped up quickly through pilot and commercial projects. Lilac is a mining technology company and is building partnerships with brine developers and operators around the world.

Lilac Solutions has developed a new ion exchange technology to address the challenges faced by lithium producers. Lilac's technology cuts capital and operating costs, accelerates project startup, boosts lithium recovery, and unlocks new resources. Their process is modular and can be ramped up quickly through pilot and commercial projects. Lilac is a mining technology company and is building partnerships with brine developers and operators around the world.

Seaspire Skincare specializes in the development and manufacturing of multifunctional colorants and active ingredients derived from oceanic biodiversity. The company focuses on creating innovative solutions to address chronic and cosmetic hair and skin conditions while aiming to replace harmful components in traditional sunscreens. One of its key products features the biomolecule Xanthochrome, which provides enhanced protection against a wider spectrum of ultraviolet radiation compared to existing physical and chemical filters. This technology is designed for preventative skincare, promoting a healthier approach that minimizes adverse effects on both human and marine health. Through its sustainable and less toxic formulations, Seaspire Skincare contributes to advancing the skincare industry towards safer and environmentally friendly practices.

Sync Computing Corp. specializes in the development of optimization processing units (OPUs) that address complex combinatorial optimization challenges across various sectors, including telecommunications, pharmaceuticals, finance, and logistics. Founded in 2019 and headquartered in Cambridge, Massachusetts, the company offers innovative solutions that integrate advanced algorithms into hardware, enhancing the ability of organizations to tackle significant optimization issues. By leveraging its technology, Sync Computing aims to improve operational efficiency and effectiveness in industries that heavily utilize machine learning and optimization techniques.

ISEE, Inc. is a company that specializes in developing artificial intelligence software and hardware solutions for autonomous vehicles. Established in 2016 and headquartered in Cambridge, Massachusetts, ISEE focuses on creating humanistic AI that can navigate complex driving scenarios and unfamiliar situations. The company draws inspiration from computational cognitive science, aiming to ensure that its technology integrates seamlessly into society and enhances human lives. The team at ISEE comprises leading technologists and researchers from prestigious institutions such as MIT, Harvard, and Carnegie Mellon University, reflecting a commitment to innovative thinking in the field of AI autonomy.

E25Bio specializes in the development of rapid diagnostic tests for epidemic fever viruses. It is dedicated to preventing severe downstream health outcomes with the use of mobile, fast, real-time reporting to create unprecedented large datasets to guide informed and timely responses for the control of disease spread. The company was founded in 2018 and is headquartered in Cambridge, Massachusetts.

Form Energy, Inc. specializes in developing long-duration energy storage systems aimed at facilitating the transition from fossil fuels to renewable energy sources. The company focuses on creating low-cost battery solutions capable of storing electricity generated from wind and solar power for extended periods, thereby enhancing the reliability of the electric grid. Its core technology, which includes an innovative iron-air battery, allows for energy dispatch over multiple days, significantly improving the viability of renewable energy as a consistent power source. Founded in 2017 and headquartered in Somerville, Massachusetts, Form Energy also offers Formware, a software tool designed for capacity expansion with advanced optimization capabilities. The company's mission revolves around enabling deep decarbonization of the electric system, ultimately contributing to a more sustainable energy future. Form Energy has garnered support from various investors, including Breakthrough Energy Ventures and MIT’s The Engine.

Syzygy Plasmonics is a developer of a photocatalytic reactor designed for fuel cell vehicles and small-scale industrial applications.The company's reactor is powered by light and operates at over 1,000°F lower temperature than conventional chemical reactor technology that helps in reducing maintenance costs and is able to start or stop production near instantaneously, enabling fuel cell vehicle companies to produce ultra-low-cost hydrogen gas on-site at customer locations.

Mori, officially known as Cambridge Crops, Inc., specializes in the development of an innovative biopolymer coating designed to extend the shelf life of perishable foods. Established in 2016 and headquartered in Boston, Massachusetts, the company utilizes a unique process that extracts protein from natural silk using salt and water. This edible and natural coating forms a protective layer over various food items, including fruits, vegetables, meat, and seafood, effectively slowing down spoilage. Through its technology, Mori aims to enhance the freshness of food while promoting sustainability in the food supply chain.

Lucy Therapeutics is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative treatments for neurological diseases that originate in the mitochondria. Founded in 2017, the company employs a unique drug discovery approach that targets early disease pathogenesis, aiming to modify disease progression rather than merely alleviate symptoms. Their primary focus is on Rett Syndrome, a severe pediatric condition for which no effective drug treatments currently exist. In addition to Rett Syndrome, Lucy Therapeutics plans to expand its research to address other neurologically focused diseases, including Parkinson's and Alzheimer's diseases. The company also develops proprietary small molecule therapies and diagnostic biomarkers for the central nervous system, utilizing genetic technologies to provide insights into personalized medicine and enhance patient outcomes.

Commonwealth Fusion Systems LLC is a research company focused on developing fusion energy as a sustainable solution to combat climate change. Established in 2017 and based in Cambridge, Massachusetts, the company utilizes advanced rare-earth barium copper oxide superconductor technology to create energy through fusion. Commonwealth Fusion Systems combines decades of government-funded fusion research with innovative superconducting magnet technology to expedite the commercialization of fusion energy. The company emerged from the Massachusetts Institute of Technology and collaborates closely with MIT’s Plasma Science and Fusion Center, leveraging extensive research to enhance its development efforts. By designing and building fusion machines, Commonwealth Fusion aims to provide limitless and clean energy, contributing to the global transition toward sustainable energy sources.

Vaxess Technologies, Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2011. It specializes in developing and commercializing silk biomaterial technologies aimed at improving vaccine delivery and storage. The company has created the MIMIX microneedle platform, which facilitates transdermal delivery of vaccines and therapies, and the MATRIX formulation and drying platform, which enhances the stability of vaccines, therapeutics, and diagnostic products. By utilizing a silk-derived protein, Vaxess enables vaccines to be stored and transported without refrigeration, thereby reducing distribution costs and increasing access to essential healthcare products globally.

Kytopen Corp. is a biotechnology company based in Cambridge, Massachusetts, focused on advancing cell therapy through its innovative Flowfect technology. Established in 2017, Kytopen specializes in non-viral delivery systems for molecules into challenging immune cells that are typically hard to transfect. The company utilizes a combination of microfluidics and automation to streamline the delivery process, making it faster, more efficient, and cost-effective. By employing a unique platform that integrates continuous fluid flow with electric fields, Kytopen enables researchers to produce high-quality engineered cells in a matter of minutes while preserving their health and functionality. This approach supports the discovery of novel biological insights and the development of affordable cell and gene therapies.

Zapata Computing is a quantum software company that offers computing solutions for industrial and commercial use. It provides hardware-agnostic solutions for simulation, optimization, and machine learning applications in chemistry, finance, logistics, pharmaceuticals, engineering, and materials. Zapata Computing is a spun out of Harvard University launched by a group of Harvard scientists, including Alán Aspuru-Guzik. The company was founded in 2017 and is headquartered in Boston, Massachusetts.

Cellino Biotech, Inc. is a biotechnology company based in Cambridge, Massachusetts, founded in 2017. It specializes in intracellular delivery lasers and nanotechnology specifically for gene editing applications. The company has developed an AI-guided laser editing platform that automates the generation of personalized, autologous cell therapies, significantly reducing the development time of engineered cells from years to weeks. By integrating advanced tools from optics, biology, and computation, Cellino makes stem cell differentiation a digital process, allowing healthcare providers to efficiently produce functionally mature cells at scale. This innovative approach aims to enhance the accessibility of life-saving medicines for patients.

Via Separations, Inc. is a company based in Somerville, Massachusetts, focused on developing membrane-based products for the efficient separation of industrial liquids in complex environments. Incorporated in 2016, the company utilizes advanced materials technology that significantly reduces energy consumption—reportedly using ten times less energy than traditional separation methods. Via Separations specializes in industrial decarbonization through its innovative membrane filtration systems, improving selectivity between nano filtration solutes while enhancing temperature stability, solvent resistance, and oxidizer tolerance. This enables manufacturing facilities to increase productivity while minimizing their energy usage.

Boston Metal is a technology company specializing in industrial-scale metal production solutions through its innovative Molten Oxide Electrolysis (MOE) process. Founded in 2012 as a spin-out from MIT, the company focuses on providing the metals industry with an efficient, cost-effective, and environmentally friendly method for producing various metals and alloys from diverse feedstocks. The MOE technology employs an electrolytic cell to convert raw iron ore into ferroalloys, which are essential for manufacturing specific grades of steel. Since its inception, Boston Metal has successfully scaled its technology by 1,000 times, producing thousands of kilograms of metal. The company is headquartered in Woburn, Massachusetts, where it operates its industrial development center.

Radix Labs develops software that automates laboratory operations, enabling biologists to streamline their experimentation processes. Based in the United States, the company aims to serve as the operating system for laboratories by integrating with existing on-premise hardware from various manufacturers. Their platform compiles chemical processes into high-level programs, which describe fluid handling protocols and facilitate robotic execution. This innovative approach allows laboratories to enhance efficiency and mimic the mass production techniques found in manufacturing, ultimately improving the design, scheduling, execution, and analysis of laboratory work.

HyperLight is looking to revolutionize integrated photonic technologies through fundamental hardware innovation.

Form Energy, Inc. specializes in developing long-duration energy storage systems aimed at facilitating the transition from fossil fuels to renewable energy sources. The company focuses on creating low-cost battery solutions capable of storing electricity generated from wind and solar power for extended periods, thereby enhancing the reliability of the electric grid. Its core technology, which includes an innovative iron-air battery, allows for energy dispatch over multiple days, significantly improving the viability of renewable energy as a consistent power source. Founded in 2017 and headquartered in Somerville, Massachusetts, Form Energy also offers Formware, a software tool designed for capacity expansion with advanced optimization capabilities. The company's mission revolves around enabling deep decarbonization of the electric system, ultimately contributing to a more sustainable energy future. Form Energy has garnered support from various investors, including Breakthrough Energy Ventures and MIT’s The Engine.

Cambridge Electronics, Inc. is a manufacturer specializing in transistors and power electronic circuits designed for the development of computers and cell phones. Founded in 2012 and based in Cambridge, Massachusetts, the company’s products find applications in various sectors, including data centers, communication systems, electric vehicles, and consumer electronics.

Analytical Space, Inc. operates a satellite relay network that facilitates the rapid transmission of data from imaging satellites to the ground. Founded in 2016 and based in Cambridge, Massachusetts, the company focuses on creating an in-orbit communication infrastructure that enhances the accessibility and immediacy of satellite data. By offering services that ensure backward compatibility, high throughput, and low latency, Analytical Space aims to provide satellite operators with real-time insights into global developments.

C2Sense, Inc. specializes in the development of chemiresistive gas sensors aimed at applications in food and agriculture. The company’s sensors detect gases such as ethylene and biogenic amines at very low concentrations, facilitating the monitoring of fruit ripeness and the freshness of meat, fish, and poultry throughout the supply chain. By providing accurate data, C2Sense enables growers, shippers, distributors, retailers, and consumers to make informed decisions that help reduce food waste. Founded in 2013 as a spinout from MIT, C2Sense employs nanotechnology and advanced chemical engineering techniques to create miniaturized mobile sensing solutions. In addition to food-related applications, the company’s technology addresses challenges in rapid medical diagnostics, product authentication, environmental monitoring, and safety across various sectors. Based in Cambridge, Massachusetts, C2Sense is committed to promoting a healthier and safer world through its innovative sensing technology.

Suono Bio, Inc. is focused on developing a novel platform technology for the rapid and localized delivery of therapeutic products, specifically targeting the gastrointestinal (GI) tract. Incorporated in 2016 and based in Medford, Massachusetts, the company aims to facilitate the administration of small molecules, proteins, vaccines, and nucleic acids without the need for encapsulation. Preclinical studies have shown the platform's effectiveness in delivering various therapeutics both locally and systemically, which supports its potential for treating inflammatory-mediated diseases. This innovative approach may offer significant advancements in therapeutic delivery, enhancing patient recovery from gastrointestinal conditions.

Baseload Renewables develops low-cost energy storage to replace fossil base-load generation with renewable energy.

Via Separations, Inc. is a company based in Somerville, Massachusetts, focused on developing membrane-based products for the efficient separation of industrial liquids in complex environments. Incorporated in 2016, the company utilizes advanced materials technology that significantly reduces energy consumption—reportedly using ten times less energy than traditional separation methods. Via Separations specializes in industrial decarbonization through its innovative membrane filtration systems, improving selectivity between nano filtration solutes while enhancing temperature stability, solvent resistance, and oxidizer tolerance. This enables manufacturing facilities to increase productivity while minimizing their energy usage.

Kytopen Corp. is a biotechnology company based in Cambridge, Massachusetts, focused on advancing cell therapy through its innovative Flowfect technology. Established in 2017, Kytopen specializes in non-viral delivery systems for molecules into challenging immune cells that are typically hard to transfect. The company utilizes a combination of microfluidics and automation to streamline the delivery process, making it faster, more efficient, and cost-effective. By employing a unique platform that integrates continuous fluid flow with electric fields, Kytopen enables researchers to produce high-quality engineered cells in a matter of minutes while preserving their health and functionality. This approach supports the discovery of novel biological insights and the development of affordable cell and gene therapies.

ISEE, Inc. is a company that specializes in developing artificial intelligence software and hardware solutions for autonomous vehicles. Established in 2016 and headquartered in Cambridge, Massachusetts, ISEE focuses on creating humanistic AI that can navigate complex driving scenarios and unfamiliar situations. The company draws inspiration from computational cognitive science, aiming to ensure that its technology integrates seamlessly into society and enhances human lives. The team at ISEE comprises leading technologists and researchers from prestigious institutions such as MIT, Harvard, and Carnegie Mellon University, reflecting a commitment to innovative thinking in the field of AI autonomy.