Early Stage Partners, LP

Established in 2001, Early Stage Partners is a Cleveland-based private equity firm that targets investments in early-stage technology companies in the United States.

Jim Petras

Managing Director

40 past transactions

HistoSonics

Series B in 2017
HistoSonics provides the Edison Platform, which uses advanced imaging and proprietary sensing technology to deliver non-invasive, personalized treatments with precision and control, and uses the science of histotripsy and focused sound energy to generate pressures to liquify and completely destroy targeted tissues at sub-cellular levels.

OnShift

Series D in 2016
OnShift provides cloud-based human capital management software and proactive services tailored for the healthcare sector. Its suite of products focuses on hiring, scheduling, and employee engagement, addressing common workforce challenges faced by organizations. By leveraging intuitive design and predictive analytics, OnShift enables healthcare providers to optimize staffing, ensuring consistent and efficient care delivery. This approach not only enhances the quality of care but also contributes to lower operational costs and improved performance. Thousands of post-acute care and senior living organizations depend on OnShift’s solutions to manage their workforce effectively.

Amplifinity

Series B in 2014
Amplifinity, LLC specializes in developing and providing referral software designed for Fortune 500 companies and advocates. The company's Advocate Management Platform (AMP) equips organizations with tools to implement word-of-mouth marketing campaigns efficiently. Key features of AMP include the Program Builder, which allows users to design, launch, and analyze various advocacy campaigns, and the Advocate Database, which maintains individual profiles for advocates. Amplifinity's platform automates the tracking and management of customer and partner referrals, ensuring streamlined reward fulfillment and incentive structures. It serves diverse sectors such as travel, entertainment, financial services, and home goods. Established in 2007 and based in Ann Arbor, Michigan, Amplifinity operates as a subsidiary of Impartner Software, Inc. Notable clients include ADP, LogMeIn, and Citrix.

OnShift

Series C in 2014
OnShift provides cloud-based human capital management software and proactive services tailored for the healthcare sector. Its suite of products focuses on hiring, scheduling, and employee engagement, addressing common workforce challenges faced by organizations. By leveraging intuitive design and predictive analytics, OnShift enables healthcare providers to optimize staffing, ensuring consistent and efficient care delivery. This approach not only enhances the quality of care but also contributes to lower operational costs and improved performance. Thousands of post-acute care and senior living organizations depend on OnShift’s solutions to manage their workforce effectively.

Juventas Therapeutics

Series B in 2012
Juventas Therapeutics, Inc., a clinical stage biotechnology company, develops non-viral gene therapies that activate natural processes to repair the body. The company focuses on treatment of non-healing wounds in patients with advanced peripheral artery disease. It offers JVS-100, a non-viral gene therapy that expresses stromal cell-derived factor-1 or SDF-1, a naturally occurring signaling protein that has been shown to recruit the body’s own stem cells and promote tissue repair in a range of disease states. Juventas Therapeutics, Inc. was formerly known as AcelleRX Therapeutics, Inc. and changed its name to Juventas Therapeutics, Inc. in April 2009. The company was founded in 2007 and is based in Cleveland, Ohio.

OnShift

Series B in 2012
OnShift provides cloud-based human capital management software and proactive services tailored for the healthcare sector. Its suite of products focuses on hiring, scheduling, and employee engagement, addressing common workforce challenges faced by organizations. By leveraging intuitive design and predictive analytics, OnShift enables healthcare providers to optimize staffing, ensuring consistent and efficient care delivery. This approach not only enhances the quality of care but also contributes to lower operational costs and improved performance. Thousands of post-acute care and senior living organizations depend on OnShift’s solutions to manage their workforce effectively.

LineStream Technologies

Series B in 2012
LineStream Technologies, Inc. develops and delivers motor, motion, and industrial control software. It offers embedded software for automated products and processes. LineStream Technologies, Inc. was formerly known as ADRC Technologies, Inc. and changed its name to LineStream Technologies, Inc. in March 2010. The company was founded in 2006 and is based in Cleveland, Ohio.

CytoPherx

Series C in 2012
CytoPherx (formerly Nephrion) clinical stage medical device company addressing inflammation-based diseases and conditions. The company’s products are custom configurations of a proprietary selective cytopheresis-based inflammation modulating system.

Amplifinity

Series A in 2011
Amplifinity, LLC specializes in developing and providing referral software designed for Fortune 500 companies and advocates. The company's Advocate Management Platform (AMP) equips organizations with tools to implement word-of-mouth marketing campaigns efficiently. Key features of AMP include the Program Builder, which allows users to design, launch, and analyze various advocacy campaigns, and the Advocate Database, which maintains individual profiles for advocates. Amplifinity's platform automates the tracking and management of customer and partner referrals, ensuring streamlined reward fulfillment and incentive structures. It serves diverse sectors such as travel, entertainment, financial services, and home goods. Established in 2007 and based in Ann Arbor, Michigan, Amplifinity operates as a subsidiary of Impartner Software, Inc. Notable clients include ADP, LogMeIn, and Citrix.

CardioX

Series C in 2011
CardioX is a company that specializes in developing advanced systems for measuring and monitoring various cardiovascular health parameters, including cardiac output, total circulating blood volume, and endogenous blood ammonia levels. Founded in 1996 and based in Columbus, Ohio, CardioX has expanded its offerings to include a mobile application for tracking and recording electrocardiograms (ECG). This app leverages a vast dataset from clinical records to enhance its machine learning algorithms, enabling the detection of abnormalities in cardiac patterns. Notably, CardioX has achieved a breakthrough in real-time blood pressure monitoring, providing users with accurate on-the-fly readings. The company is actively working on integrating data from third-party activity trackers and enhancing its artificial intelligence capabilities, which will allow users to interpret ECG graphs through simple image uploads. CardioX aims to harness these advancements to improve heart health management and expand the range of vital health parameters that can be monitored through its technology.

SironRX Therapeutics

Series A in 2011
SironRX is developing novel therapies exclusively licensed from Juventas Therapeutics and Cleveland Clinic that promote dermal wound repair and reduce scarring. Our lead product is a clinically tested biopharmaceutical that encodes Stromal cell-Derived Factor-1 (SDF-1). SDF-1 is key molecule responsible for activating natural repair processes after tissue injury through prevention of cell death and recruitment of stem cells to the damaged organ. Studies from several laboratories suggest the therapeutic potential of SDF-1 for treatment of a range of wounds such as post-surgical incisions, chronic diabetic ulcers and burns. Development of a cost-effective interactive wound therapy that can be topically administered at the site-of-injury or in chronic wound care settings with the potential to significantly improve function of the damaged tissue will have a major impact on the multi-billion dollar advanced wound management market.

TOA Technologies

Series D in 2011
TOA Technologies specializes in field service management software designed for businesses that operate in the field. Their flagship product, ETAdirect, is a cloud-based solution that utilizes a patented time-based predictive analytics platform. ETAdirect analyzes how work is performed by individual employees, identifies patterns, and predicts the most efficient routes based on real-time data. This system communicates updates to consumers throughout the service process, enhancing transparency and engagement. By implementing ETAdirect, TOA's clients can improve the effectiveness of their field service teams, leading to reduced customer wait times and increased productivity in service operations.

OnShift

Series A in 2010
OnShift provides cloud-based human capital management software and proactive services tailored for the healthcare sector. Its suite of products focuses on hiring, scheduling, and employee engagement, addressing common workforce challenges faced by organizations. By leveraging intuitive design and predictive analytics, OnShift enables healthcare providers to optimize staffing, ensuring consistent and efficient care delivery. This approach not only enhances the quality of care but also contributes to lower operational costs and improved performance. Thousands of post-acute care and senior living organizations depend on OnShift’s solutions to manage their workforce effectively.

AxioMed

Series D in 2010
AxioMed LLC, founded in 2001 and located in Malden, Massachusetts, specializes in designing and developing disc replacement devices aimed at alleviating neck pain and restoring normal spinal functions for patients suffering from degenerative disc disease. The company, previously known as AxioMed Spine Corporation until its name change in 2014, has focused on advancing the standard of care beyond traditional fusion and first-generation artificial discs. AxioMed has developed the Freedom® Lumbar Disc and is currently working on a project for cervical spine applications, having initiated clinical trials for its products. The management team, led by CEO Patrick McBrayer and COO James Kuras, consists of experienced professionals with significant expertise in spinal implants. Additionally, AxioMed collaborates with a Medical Advisory Panel of surgeons from prominent spine centers and universities to enhance its product development and regulatory strategies.
Prevacept Infection Control is a clinical-stage company focused on developing and commercializing products that prevent infections associated with indwelling catheters.

Intelligent Clearing Network

Venture Round in 2010
Intelligent Clearing Network, Inc., a software as a service company, electronically validates and clears paper and digital coupons, and other incentives for grocery, drug, and mass merchant retailers. The company provides fully-automated end-to-end promotion management system gives retailers complete control over all of their promotions and eliminates costly fraud. The company offers services, such as promotion management, coupon validation, fraud protection, digital, and direct-to-card offers. The company was incorporated in 2008 and is based in North Haven, Connecticut.

Reverse Medical

Series B in 2010
Reverse Medical is a commercial-stage medical device company focused on revascularizing patients experiencing Acute Ischemic Stroke.

Simbionix

Series C in 2008
Simbionix USA Corporation provides simulation, training, and education solutions for medical professionals and the healthcare industry. It offers laparoscopic surgical, multidisciplinary endovascular surgical, endoscopic medical, bronchoscopy training, and endouroloy training simulators.Simbionix Learning Management System tracks and reports learner’s performances; and PROcedure Rehearsal Studio, which allows clinicians to create a patient specific 3D virtual anatomical model based on the patient’s CT.It offers its products through distributors in the Middle East and Gulf countries, South America, the Asia-Pacific, and Europe. The company also serves surgeons, interventionists, nurses, and technicians. Simbionix USA Corporation was founded in 1997 and is based in Cleveland, Ohio with a research and development center in Israel.

Juventas Therapeutics

Series A in 2008
Juventas Therapeutics, Inc., a clinical stage biotechnology company, develops non-viral gene therapies that activate natural processes to repair the body. The company focuses on treatment of non-healing wounds in patients with advanced peripheral artery disease. It offers JVS-100, a non-viral gene therapy that expresses stromal cell-derived factor-1 or SDF-1, a naturally occurring signaling protein that has been shown to recruit the body’s own stem cells and promote tissue repair in a range of disease states. Juventas Therapeutics, Inc. was formerly known as AcelleRX Therapeutics, Inc. and changed its name to Juventas Therapeutics, Inc. in April 2009. The company was founded in 2007 and is based in Cleveland, Ohio.

Arisdyne

Series A in 2008
Arisdyne Systems is an advanced materials and process systems integration company. They license continuous flow, high efficiency systems to manufacturers of fuels. Their integrated, labor efficient systems scale easily from their lab to your plant site. The Arisdyne Systems team brings over 50 years of technological expertise to the industry.

EcoSMART Technologies

Venture Round in 2008
EcoSMART Technologies, Inc. manufactures pesticide solutions and pet care products based on natural ingredients. The company offers a range of pest control products, including ant and roach killers; bed bug killers and repellents; flea and tick control products, repellents, and sprays; flying insect killers, granules, and repellents; garden fungicides; garden insect killers; home pest control products; lawn insect killers; mosquito and tick control products; mosquito foggers; spider blasters; wasp and hornet killers; and weed and grass killers. It also provides pet care products, including conditioners, detanglers, shampoos, flea and tick controls, repellents, and sprays for residential and commercial markets. It offers its products online, as well as through retail stores. The company was founded in 1992 and is headquartered in Atlanta, Georgia. EcoSMART Technologies, Inc. operates as a subsidiary of Kittrich Corporation.

LineStream Technologies

Series A in 2008
LineStream Technologies, Inc. develops and delivers motor, motion, and industrial control software. It offers embedded software for automated products and processes. LineStream Technologies, Inc. was formerly known as ADRC Technologies, Inc. and changed its name to LineStream Technologies, Inc. in March 2010. The company was founded in 2006 and is based in Cleveland, Ohio.

Imalux Corporation

Series C in 2007
Imalux Corporation, an Ohio medical device company, is positioned to become the worldwide leader in the commercializationPhoto of medical imaging equipment and devices based on its proprietary Optical Coherence Tomography (OCT) technology. The Company’s products provide real-time, high spatial resolution imaging at the point-of-care in a variety of medical applications. OCT is a new imaging modality for visualization of tissue microstructure, especially in anatomical areas with stratified tissue. It has the ability to detect near-surface tissue abnormalities indicative of disease, which established imaging modalities might not detect. Many diseases, including cancer, are associated with superficial tissue structure disruption. Today, there is no commercialized in vivo method to visualize this tissue structure alteration; clinicians must do a biopsy and an ex vivo histopathological review using a conventional microscope. Imalux OCT products can be used to visualize structural disruptions in vivo at the point of care.

Blue Spark Technologies

Series A in 2007
Blue Spark Technologies develops power source solutions for battery-powered printed electronic systems. It also develops flexible, printed, "green," proprietary power source solutions for battery-powered printed electronic systems. The company was founded as Thin Battery Technologies in 2002 with patented technology and technical leadership from Energizer (Eveready Battery Company). Blue Spark Technologies was founded in 2003 and headquartered in Westlake, Ohio.

Five Star Technologies

Venture Round in 2006
Five Star Technologies is a supplier of high-performance dispersions, inks and pastes used in displays, photovoltaics, and microelectronic packaging. Combining its patented hydrodynamic cavitation process with innovative chemistry, Five Star produces the ElectroSperseâ„¢ series of inks and pastes as well as a wide range of precision dispersions. The ElectroSperse line features a range of conductive pastes with exceptional printability, low firing temperatures, high levels of conductivity, strong adhesion to a variety of substrates, and RoHS compliance. ElectroSperse grades can be tailored for a range of processing techniques, including screen, gravure, extrusion and ink jet printing. Targeted applications include electrodes, interconnects, and linearization patterns for displays, photovoltaic front side contacts, and hybrid microcircuits.

EcoSMART Technologies

Series C in 2006
EcoSMART Technologies, Inc. manufactures pesticide solutions and pet care products based on natural ingredients. The company offers a range of pest control products, including ant and roach killers; bed bug killers and repellents; flea and tick control products, repellents, and sprays; flying insect killers, granules, and repellents; garden fungicides; garden insect killers; home pest control products; lawn insect killers; mosquito and tick control products; mosquito foggers; spider blasters; wasp and hornet killers; and weed and grass killers. It also provides pet care products, including conditioners, detanglers, shampoos, flea and tick controls, repellents, and sprays for residential and commercial markets. It offers its products online, as well as through retail stores. The company was founded in 1992 and is headquartered in Atlanta, Georgia. EcoSMART Technologies, Inc. operates as a subsidiary of Kittrich Corporation.
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that discovers and develops small molecule drugs that modulate programmed cell death pathways to treat debilitating diseases and conditions. The company's Smac Mimetics neutralize critical blocks in the apoptosis pathway to selectively destroy cancer cells. Its Necrostatin drugs block critical steps in the process leading to necrosis, enabling cell survival in a wide range of diseases and injuries where necrosis is a critical component of pathology.

LogMeIn

Series B in 2005
LogMeIn, Inc. is a provider of cloud-based communication, collaboration, identity and access, and customer engagement solutions. The company offers a range of products designed to facilitate remote connectivity and enhance user interactions. Key offerings include GoToConnect for video and audio conferencing, GoToMeeting for online collaboration, and GoToWebinar for hosting webinars. Additionally, LogMeIn provides remote support services through LogMeIn Rescue and GoToAssist, and a suite of tools for managing remote work, such as LogMeIn Pro and GoToMyPC. The company also features Bold360, an omni-channel engagement platform, and LastPass for password management. Founded in 2003 and headquartered in Boston, Massachusetts, LogMeIn serves a diverse clientele, including enterprise customers, small and medium businesses, IT service providers, and individual consumers. The company aims to simplify how people connect and collaborate across various platforms and locations.

Unitask

Series A in 2005
Unitask, Inc. develops and sells software solutions designed to automate tasks related to the Oracle E-Business Suite (EBS). Its key products include Unitask Output Director, which streamlines output management by automating printer configurations and enabling users to print, fax, email, and store reports; and Unitask Migration Director, which facilitates the automation of code migrations within Oracle EBS. Additionally, the Unitask Command Center provides a web-based interface for managing these automation solutions. The company's software serves a diverse range of industries such as oil and gas, manufacturing, engineering, healthcare, and government, among others. Unitask, founded in 1994 and headquartered in Bloomfield Hills, Michigan, also has operations in Israel and serves customers globally across North America, South America, Europe, Asia, Australia, and Africa.

TOA Technologies

Series B in 2005
TOA Technologies specializes in field service management software designed for businesses that operate in the field. Their flagship product, ETAdirect, is a cloud-based solution that utilizes a patented time-based predictive analytics platform. ETAdirect analyzes how work is performed by individual employees, identifies patterns, and predicts the most efficient routes based on real-time data. This system communicates updates to consumers throughout the service process, enhancing transparency and engagement. By implementing ETAdirect, TOA's clients can improve the effectiveness of their field service teams, leading to reduced customer wait times and increased productivity in service operations.

AxioMed

Series B in 2005
AxioMed LLC, founded in 2001 and located in Malden, Massachusetts, specializes in designing and developing disc replacement devices aimed at alleviating neck pain and restoring normal spinal functions for patients suffering from degenerative disc disease. The company, previously known as AxioMed Spine Corporation until its name change in 2014, has focused on advancing the standard of care beyond traditional fusion and first-generation artificial discs. AxioMed has developed the Freedom® Lumbar Disc and is currently working on a project for cervical spine applications, having initiated clinical trials for its products. The management team, led by CEO Patrick McBrayer and COO James Kuras, consists of experienced professionals with significant expertise in spinal implants. Additionally, AxioMed collaborates with a Medical Advisory Panel of surgeons from prominent spine centers and universities to enhance its product development and regulatory strategies.

Imalux Corporation

Series B in 2005
Imalux Corporation, an Ohio medical device company, is positioned to become the worldwide leader in the commercializationPhoto of medical imaging equipment and devices based on its proprietary Optical Coherence Tomography (OCT) technology. The Company’s products provide real-time, high spatial resolution imaging at the point-of-care in a variety of medical applications. OCT is a new imaging modality for visualization of tissue microstructure, especially in anatomical areas with stratified tissue. It has the ability to detect near-surface tissue abnormalities indicative of disease, which established imaging modalities might not detect. Many diseases, including cancer, are associated with superficial tissue structure disruption. Today, there is no commercialized in vivo method to visualize this tissue structure alteration; clinicians must do a biopsy and an ex vivo histopathological review using a conventional microscope. Imalux OCT products can be used to visualize structural disruptions in vivo at the point of care.
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that discovers and develops small molecule drugs that modulate programmed cell death pathways to treat debilitating diseases and conditions. The company's Smac Mimetics neutralize critical blocks in the apoptosis pathway to selectively destroy cancer cells. Its Necrostatin drugs block critical steps in the process leading to necrosis, enabling cell survival in a wide range of diseases and injuries where necrosis is a critical component of pathology.

Five Star Technologies

Series C in 2003
Five Star Technologies is a supplier of high-performance dispersions, inks and pastes used in displays, photovoltaics, and microelectronic packaging. Combining its patented hydrodynamic cavitation process with innovative chemistry, Five Star produces the ElectroSperseâ„¢ series of inks and pastes as well as a wide range of precision dispersions. The ElectroSperse line features a range of conductive pastes with exceptional printability, low firing temperatures, high levels of conductivity, strong adhesion to a variety of substrates, and RoHS compliance. ElectroSperse grades can be tailored for a range of processing techniques, including screen, gravure, extrusion and ink jet printing. Targeted applications include electrodes, interconnects, and linearization patterns for displays, photovoltaic front side contacts, and hybrid microcircuits.

Imalux Corporation

Series A in 2003
Imalux Corporation, an Ohio medical device company, is positioned to become the worldwide leader in the commercializationPhoto of medical imaging equipment and devices based on its proprietary Optical Coherence Tomography (OCT) technology. The Company’s products provide real-time, high spatial resolution imaging at the point-of-care in a variety of medical applications. OCT is a new imaging modality for visualization of tissue microstructure, especially in anatomical areas with stratified tissue. It has the ability to detect near-surface tissue abnormalities indicative of disease, which established imaging modalities might not detect. Many diseases, including cancer, are associated with superficial tissue structure disruption. Today, there is no commercialized in vivo method to visualize this tissue structure alteration; clinicians must do a biopsy and an ex vivo histopathological review using a conventional microscope. Imalux OCT products can be used to visualize structural disruptions in vivo at the point of care.

Netilla Networks

Series C in 2003
Netilla Networks specializes in providing secure remote access solutions for corporate networks through its Netilla Service Platform, which is recognized as a leading SSL VPN appliance. This platform allows organizations to offer secure access to any application, whether on Windows, UNIX/Linux, or mainframe systems, via standard web browsers. By integrating thin-client technology with SSL encryption, along with a robust authentication and policy framework, Netilla Networks enables rapid deployment and reduces network exposure. The system is designed to lower maintenance costs compared to traditional VPNs while ensuring a user-friendly experience.

AxioMed

Series A in 2003
AxioMed LLC, founded in 2001 and located in Malden, Massachusetts, specializes in designing and developing disc replacement devices aimed at alleviating neck pain and restoring normal spinal functions for patients suffering from degenerative disc disease. The company, previously known as AxioMed Spine Corporation until its name change in 2014, has focused on advancing the standard of care beyond traditional fusion and first-generation artificial discs. AxioMed has developed the Freedom® Lumbar Disc and is currently working on a project for cervical spine applications, having initiated clinical trials for its products. The management team, led by CEO Patrick McBrayer and COO James Kuras, consists of experienced professionals with significant expertise in spinal implants. Additionally, AxioMed collaborates with a Medical Advisory Panel of surgeons from prominent spine centers and universities to enhance its product development and regulatory strategies.

Netilla Networks

Series B in 2001
Netilla Networks specializes in providing secure remote access solutions for corporate networks through its Netilla Service Platform, which is recognized as a leading SSL VPN appliance. This platform allows organizations to offer secure access to any application, whether on Windows, UNIX/Linux, or mainframe systems, via standard web browsers. By integrating thin-client technology with SSL encryption, along with a robust authentication and policy framework, Netilla Networks enables rapid deployment and reduces network exposure. The system is designed to lower maintenance costs compared to traditional VPNs while ensuring a user-friendly experience.
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