Early Stage Partners

Founded in 2001, Early Stage Partners is an Ohio-based investment firm targeting information technology, healthcare, manufacturing and industrial technology companies in the Midwest.

Mike Bunker

MD, Life Sciences investments

EC

Ethan Cohen

MD

Jamie Ireland

MD

Charles (Charlie) Macmillan

CFO

Jim Petras

MD

JM

James M. Petras

General Partner

40 past transactions

OnShift

Series C in 2014
OnShift delivers cloud-based human capital management software and proactive services to solve everyday workforce challenges in healthcare. Our suite of products for hiring, scheduling and employee engagement drives quality care, lower costs and higher performance by empowering providers to staff consistently and efficiently. Intuitive design, predictive analytics and customer success management are why thousands of post-acute care and senior living organizations rely on OnShift.

OnShift

Series B in 2012
OnShift delivers cloud-based human capital management software and proactive services to solve everyday workforce challenges in healthcare. Our suite of products for hiring, scheduling and employee engagement drives quality care, lower costs and higher performance by empowering providers to staff consistently and efficiently. Intuitive design, predictive analytics and customer success management are why thousands of post-acute care and senior living organizations rely on OnShift.

LogMeIn

Series B in 2005
LogMeIn, Inc. (NASDAQ:LOGM) simplifies how people connect with each other and the world around them to drive meaningful interactions, deepen relationships, and create better outcomes for individuals and businesses. Current products include: LogMeIn Pro, LogMeIn Central, LogMeIn Rescue, Bold360, join.me, Jive, LastPass, GoToMeeting, GoToWebinar, GoToTraining, GoToAssist, GoToMyPC, OpenVoice and Grasshopper. Founded in 2003, LogMeIn is headquartered in Boston with additional locations in North America, Europe, Asia and Australia.

Arisdyne Systems

Series A in 2008
Arisdyne Systems is an advanced materials and process systems integration company. They license continuous flow, high efficiency systems to manufacturers of fuels. Their integrated, labor efficient systems scale easily from their lab to your plant site. The Arisdyne Systems team brings over 50 years of technological expertise to the industry.
Intelligent Clearing Network, Inc., a software as a service company, electronically validates and clears paper and digital coupons, and other incentives for grocery, drug, and mass merchant retailers. The company provides fully-automated end-to-end promotion management system gives retailers complete control over all of their promotions and eliminates costly fraud. The company offers services, such as promotion management, coupon validation, fraud protection, digital, and direct-to-card offers. The company was incorporated in 2008 and is based in North Haven, Connecticut.

CardioX

Venture Round in 2013
Cardiox Corporation develops and offers systems that measure and monitor cardiac output, total circulating blood volume, and endogenous blood ammonia levels. The company was founded in 1996 and is based in Columbus, Ohio.

Netilla Networks

Series B in 2001
The Netilla® Service Platform is the industry's leading SSL VPN appliance that enables companies to provide secure remote and intranet access to ANY application - Windows®, UNIX®/Linux®, or mainframe - via a standard browser. Their appliance combines thin-client technology, SSL encryption and a flexible, powerful authentication and policy framework. The benefits: rapid deployment, minimized network exposure and lower maintenance costs than traditional VPNs - with unrivaled ease of use.
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that discovers and develops small molecule drugs that modulate programmed cell death pathways to treat debilitating diseases and conditions. The company's Smac Mimetics neutralize critical blocks in the apoptosis pathway to selectively destroy cancer cells. Its Necrostatin drugs block critical steps in the process leading to necrosis, enabling cell survival in a wide range of diseases and injuries where necrosis is a critical component of pathology.

EcoSMART Technologies

Series C in 2006
EcoSMART Technologies, Inc. manufactures pesticide solutions and pet care products based on natural ingredients. The company offers a range of pest control products, including ant and roach killers; bed bug killers and repellents; flea and tick control products, repellents, and sprays; flying insect killers, granules, and repellents; garden fungicides; garden insect killers; home pest control products; lawn insect killers; mosquito and tick control products; mosquito foggers; spider blasters; wasp and hornet killers; and weed and grass killers. It also provides pet care products, including conditioners, detanglers, shampoos, flea and tick controls, repellents, and sprays for residential and commercial markets. It offers its products online, as well as through retail stores. The company was founded in 1992 and is headquartered in Atlanta, Georgia. EcoSMART Technologies, Inc. operates as a subsidiary of Kittrich Corporation.

CytoPherx

Series C in 2012
CytoPherx (formerly Nephrion) clinical stage medical device company addressing inflammation-based diseases and conditions. The company’s products are custom configurations of a proprietary selective cytopheresis-based inflammation modulating system.

Imalux Corporation

Series C in 2007
Imalux Corporation, an Ohio medical device company, is positioned to become the worldwide leader in the commercializationPhoto of medical imaging equipment and devices based on its proprietary Optical Coherence Tomography (OCT) technology. The Company’s products provide real-time, high spatial resolution imaging at the point-of-care in a variety of medical applications. OCT is a new imaging modality for visualization of tissue microstructure, especially in anatomical areas with stratified tissue. It has the ability to detect near-surface tissue abnormalities indicative of disease, which established imaging modalities might not detect. Many diseases, including cancer, are associated with superficial tissue structure disruption. Today, there is no commercialized in vivo method to visualize this tissue structure alteration; clinicians must do a biopsy and an ex vivo histopathological review using a conventional microscope. Imalux OCT products can be used to visualize structural disruptions in vivo at the point of care.

Imalux Corporation

Series A in 2003
Imalux Corporation, an Ohio medical device company, is positioned to become the worldwide leader in the commercializationPhoto of medical imaging equipment and devices based on its proprietary Optical Coherence Tomography (OCT) technology. The Company’s products provide real-time, high spatial resolution imaging at the point-of-care in a variety of medical applications. OCT is a new imaging modality for visualization of tissue microstructure, especially in anatomical areas with stratified tissue. It has the ability to detect near-surface tissue abnormalities indicative of disease, which established imaging modalities might not detect. Many diseases, including cancer, are associated with superficial tissue structure disruption. Today, there is no commercialized in vivo method to visualize this tissue structure alteration; clinicians must do a biopsy and an ex vivo histopathological review using a conventional microscope. Imalux OCT products can be used to visualize structural disruptions in vivo at the point of care.

Juventas Therapeutics

Series B in 2012
Juventas Therapeutics, Inc., a clinical stage biotechnology company, develops non-viral gene therapies that activate natural processes to repair the body. The company focuses on treatment of non-healing wounds in patients with advanced peripheral artery disease. It offers JVS-100, a non-viral gene therapy that expresses stromal cell-derived factor-1 or SDF-1, a naturally occurring signaling protein that has been shown to recruit the body’s own stem cells and promote tissue repair in a range of disease states. Juventas Therapeutics, Inc. was formerly known as AcelleRX Therapeutics, Inc. and changed its name to Juventas Therapeutics, Inc. in April 2009. The company was founded in 2007 and is based in Cleveland, Ohio.

Amplifinity

Series B in 2014
Amplifinity develops referral software that automates the referral tracking and management of B2B customer and partner referral programs. Amplifinity's referral platform provides a steady flow of leads from referral sources you partner with including customers, non-reseller partners, agents, consultants, and more. Amplifinity automates the tracking and management of referrals and the handling of reward fulfillment and variable incentive structures. A Salesforce integration drives sales referral productivity. Companies like ADP, LogMeIn, and Citrix use Amplifinity to automate their referral programs and enable high-quality acquisition while providing an engaging experience for their partners. Amplifinity was formed in 2008 and is based in Ann Arbor, Michigan, USA.

OnShift

Series D in 2016
OnShift delivers cloud-based human capital management software and proactive services to solve everyday workforce challenges in healthcare. Our suite of products for hiring, scheduling and employee engagement drives quality care, lower costs and higher performance by empowering providers to staff consistently and efficiently. Intuitive design, predictive analytics and customer success management are why thousands of post-acute care and senior living organizations rely on OnShift.

Reverse Medical

Series B in 2010
Reverse Medical is a commercial-stage medical device company focused on revascularizing patients experiencing Acute Ischemic Stroke.

HistoSonics

Series B in 2017
HistoSonics provides the Edison Platform, which uses advanced imaging and proprietary sensing technology to deliver non-invasive, personalized treatments with precision and control, and uses the science of histotripsy and focused sound energy to generate pressures to liquify and completely destroy targeted tissues at sub-cellular levels.

HistoSonics

Series A in 2010
HistoSonics provides the Edison Platform, which uses advanced imaging and proprietary sensing technology to deliver non-invasive, personalized treatments with precision and control, and uses the science of histotripsy and focused sound energy to generate pressures to liquify and completely destroy targeted tissues at sub-cellular levels.

CardioX

Series C in 2011
Cardiox Corporation develops and offers systems that measure and monitor cardiac output, total circulating blood volume, and endogenous blood ammonia levels. The company was founded in 1996 and is based in Columbus, Ohio.

Amplifinity

Series A in 2011
Amplifinity develops referral software that automates the referral tracking and management of B2B customer and partner referral programs. Amplifinity's referral platform provides a steady flow of leads from referral sources you partner with including customers, non-reseller partners, agents, consultants, and more. Amplifinity automates the tracking and management of referrals and the handling of reward fulfillment and variable incentive structures. A Salesforce integration drives sales referral productivity. Companies like ADP, LogMeIn, and Citrix use Amplifinity to automate their referral programs and enable high-quality acquisition while providing an engaging experience for their partners. Amplifinity was formed in 2008 and is based in Ann Arbor, Michigan, USA.

EcoSMART Technologies

Venture Round in 2008
EcoSMART Technologies, Inc. manufactures pesticide solutions and pet care products based on natural ingredients. The company offers a range of pest control products, including ant and roach killers; bed bug killers and repellents; flea and tick control products, repellents, and sprays; flying insect killers, granules, and repellents; garden fungicides; garden insect killers; home pest control products; lawn insect killers; mosquito and tick control products; mosquito foggers; spider blasters; wasp and hornet killers; and weed and grass killers. It also provides pet care products, including conditioners, detanglers, shampoos, flea and tick controls, repellents, and sprays for residential and commercial markets. It offers its products online, as well as through retail stores. The company was founded in 1992 and is headquartered in Atlanta, Georgia. EcoSMART Technologies, Inc. operates as a subsidiary of Kittrich Corporation.
LineStream Technologies, Inc. develops and delivers motor, motion, and industrial control software. It offers embedded software for automated products and processes. LineStream Technologies, Inc. was formerly known as ADRC Technologies, Inc. and changed its name to LineStream Technologies, Inc. in March 2010. The company was founded in 2006 and is based in Cleveland, Ohio.

OnShift

Series A in 2010
OnShift delivers cloud-based human capital management software and proactive services to solve everyday workforce challenges in healthcare. Our suite of products for hiring, scheduling and employee engagement drives quality care, lower costs and higher performance by empowering providers to staff consistently and efficiently. Intuitive design, predictive analytics and customer success management are why thousands of post-acute care and senior living organizations rely on OnShift.

Five Star Technologies

Series C in 2003
Five Star Technologies is a supplier of high-performance dispersions, inks and pastes used in displays, photovoltaics, and microelectronic packaging. Combining its patented hydrodynamic cavitation process with innovative chemistry, Five Star produces the ElectroSperseâ„¢ series of inks and pastes as well as a wide range of precision dispersions. The ElectroSperse line features a range of conductive pastes with exceptional printability, low firing temperatures, high levels of conductivity, strong adhesion to a variety of substrates, and RoHS compliance. ElectroSperse grades can be tailored for a range of processing techniques, including screen, gravure, extrusion and ink jet printing. Targeted applications include electrodes, interconnects, and linearization patterns for displays, photovoltaic front side contacts, and hybrid microcircuits.

Five Star Technologies

Venture Round in 2006
Five Star Technologies is a supplier of high-performance dispersions, inks and pastes used in displays, photovoltaics, and microelectronic packaging. Combining its patented hydrodynamic cavitation process with innovative chemistry, Five Star produces the ElectroSperseâ„¢ series of inks and pastes as well as a wide range of precision dispersions. The ElectroSperse line features a range of conductive pastes with exceptional printability, low firing temperatures, high levels of conductivity, strong adhesion to a variety of substrates, and RoHS compliance. ElectroSperse grades can be tailored for a range of processing techniques, including screen, gravure, extrusion and ink jet printing. Targeted applications include electrodes, interconnects, and linearization patterns for displays, photovoltaic front side contacts, and hybrid microcircuits.

Unitask

Series A in 2005
Unitask, Inc. engages in the creation, sale, and support of software products. Its products are used by the organizations to implement, manage, and run their Oracle E-Business Suite. Unitask, Inc. products simplify printer management and allow users to print to network and desktop printer and send user and Oracle applications generated messages to the user community. Unitask, Inc. was founded in 1994 and is based in Bloomfield Hills, Michigan with additional operations in Israel.
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that discovers and develops small molecule drugs that modulate programmed cell death pathways to treat debilitating diseases and conditions. The company's Smac Mimetics neutralize critical blocks in the apoptosis pathway to selectively destroy cancer cells. Its Necrostatin drugs block critical steps in the process leading to necrosis, enabling cell survival in a wide range of diseases and injuries where necrosis is a critical component of pathology.
Prevacept Infection Control is a clinical-stage company focused on developing and commercializing products that prevent infections associated with indwelling catheters.

TOA Technologies

Series B in 2005
TOA Technologies provides field service management software for businesses that operate in the field. Natively delivered through the cloud and the only solution using a patented time-based predictive analytics platform, TOA's ETAdirect provides a new way to manage mobile field service operations. ETAdirect learns how work is done in the field according to each individual employee, creates patterns, and then predicts the most optimized routes available based on real-time, actual data communicating this information with consumers throughout the service process every step of the way. With ETAdirect's unique approach to field service management, TOA's customers are able to empower their field service teams to be more effective, resulting in reduced customer wait times and increased field service productivity.

Netilla Networks

Series C in 2003
The Netilla® Service Platform is the industry's leading SSL VPN appliance that enables companies to provide secure remote and intranet access to ANY application - Windows®, UNIX®/Linux®, or mainframe - via a standard browser. Their appliance combines thin-client technology, SSL encryption and a flexible, powerful authentication and policy framework. The benefits: rapid deployment, minimized network exposure and lower maintenance costs than traditional VPNs - with unrivaled ease of use.

Imalux Corporation

Series B in 2005
Imalux Corporation, an Ohio medical device company, is positioned to become the worldwide leader in the commercializationPhoto of medical imaging equipment and devices based on its proprietary Optical Coherence Tomography (OCT) technology. The Company’s products provide real-time, high spatial resolution imaging at the point-of-care in a variety of medical applications. OCT is a new imaging modality for visualization of tissue microstructure, especially in anatomical areas with stratified tissue. It has the ability to detect near-surface tissue abnormalities indicative of disease, which established imaging modalities might not detect. Many diseases, including cancer, are associated with superficial tissue structure disruption. Today, there is no commercialized in vivo method to visualize this tissue structure alteration; clinicians must do a biopsy and an ex vivo histopathological review using a conventional microscope. Imalux OCT products can be used to visualize structural disruptions in vivo at the point of care.

Simbionix

Series C in 2008
Simbionix USA Corporation provides simulation, training, and education solutions for medical professionals and the healthcare industry. It offers laparoscopic surgical, multidisciplinary endovascular surgical, endoscopic medical, bronchoscopy training, and endouroloy training simulators.Simbionix Learning Management System tracks and reports learner’s performances; and PROcedure Rehearsal Studio, which allows clinicians to create a patient specific 3D virtual anatomical model based on the patient’s CT.It offers its products through distributors in the Middle East and Gulf countries, South America, the Asia-Pacific, and Europe. The company also serves surgeons, interventionists, nurses, and technicians. Simbionix USA Corporation was founded in 1997 and is based in Cleveland, Ohio with a research and development center in Israel.

SironRX Therapeutics

Series A in 2011
SironRX is developing novel therapies exclusively licensed from Juventas Therapeutics and Cleveland Clinic that promote dermal wound repair and reduce scarring. Our lead product is a clinically tested biopharmaceutical that encodes Stromal cell-Derived Factor-1 (SDF-1). SDF-1 is key molecule responsible for activating natural repair processes after tissue injury through prevention of cell death and recruitment of stem cells to the damaged organ. Studies from several laboratories suggest the therapeutic potential of SDF-1 for treatment of a range of wounds such as post-surgical incisions, chronic diabetic ulcers and burns. Development of a cost-effective interactive wound therapy that can be topically administered at the site-of-injury or in chronic wound care settings with the potential to significantly improve function of the damaged tissue will have a major impact on the multi-billion dollar advanced wound management market.
Blue Spark Technologies develops power source solutions for battery-powered printed electronic systems. It also develops flexible, printed, "green," proprietary power source solutions for battery-powered printed electronic systems. The company was founded as Thin Battery Technologies in 2002 with patented technology and technical leadership from Energizer (Eveready Battery Company). Blue Spark Technologies was founded in 2003 and headquartered in Westlake, Ohio.
LineStream Technologies, Inc. develops and delivers motor, motion, and industrial control software. It offers embedded software for automated products and processes. LineStream Technologies, Inc. was formerly known as ADRC Technologies, Inc. and changed its name to LineStream Technologies, Inc. in March 2010. The company was founded in 2006 and is based in Cleveland, Ohio.

AxioMed LLC

Series B in 2005
AxioMed LLC designs and develops a disc replacement device that facilitates neck pain relief and restores normal spinal functions for patients with degenerative disc disease. AxioMed LLC was formerly known as AxioMed Spine Corporation and changed its name to AxioMed LLC in November 2014. The company was founded in 2001 and is based in Malden, Massachusetts.

AxioMed LLC

Series A in 2003
AxioMed LLC designs and develops a disc replacement device that facilitates neck pain relief and restores normal spinal functions for patients with degenerative disc disease. AxioMed LLC was formerly known as AxioMed Spine Corporation and changed its name to AxioMed LLC in November 2014. The company was founded in 2001 and is based in Malden, Massachusetts.

TOA Technologies

Series D in 2011
TOA Technologies provides field service management software for businesses that operate in the field. Natively delivered through the cloud and the only solution using a patented time-based predictive analytics platform, TOA's ETAdirect provides a new way to manage mobile field service operations. ETAdirect learns how work is done in the field according to each individual employee, creates patterns, and then predicts the most optimized routes available based on real-time, actual data communicating this information with consumers throughout the service process every step of the way. With ETAdirect's unique approach to field service management, TOA's customers are able to empower their field service teams to be more effective, resulting in reduced customer wait times and increased field service productivity.

Juventas Therapeutics

Series A in 2008
Juventas Therapeutics, Inc., a clinical stage biotechnology company, develops non-viral gene therapies that activate natural processes to repair the body. The company focuses on treatment of non-healing wounds in patients with advanced peripheral artery disease. It offers JVS-100, a non-viral gene therapy that expresses stromal cell-derived factor-1 or SDF-1, a naturally occurring signaling protein that has been shown to recruit the body’s own stem cells and promote tissue repair in a range of disease states. Juventas Therapeutics, Inc. was formerly known as AcelleRX Therapeutics, Inc. and changed its name to Juventas Therapeutics, Inc. in April 2009. The company was founded in 2007 and is based in Cleveland, Ohio.

AxioMed LLC

Series D in 2010
AxioMed LLC designs and develops a disc replacement device that facilitates neck pain relief and restores normal spinal functions for patients with degenerative disc disease. AxioMed LLC was formerly known as AxioMed Spine Corporation and changed its name to AxioMed LLC in November 2014. The company was founded in 2001 and is based in Malden, Massachusetts.