Two Sigma Ventures

Steadily is an online insurance platform that specializes in providing tailored landlord insurance coverage. Its offerings include protection against a variety of potential damages, such as those caused by weather, fire, water, vandalism, and liability for guest injuries and lawsuits. Steadily simplifies the insurance purchasing process by pre-filling essential data points like property size and year of construction, allowing landlords to obtain quotes and secure coverage directly through a mobile platform. This streamlined approach enhances the experience for property owners, enabling them to address their insurance needs efficiently without the need for intermediaries. Additionally, Steadily integrates with other property management solutions, contributing to a comprehensive suite of tools designed for short-term rental property managers.

Tive is a Boston-based startup that provides companies with end-to-end visibility into their supply chains through a sensor-driven tracking platform. The company develops a solution that combines cellular-connected trackers with cloud-based software, allowing clients to monitor, visualize, and optimize their operations in real-time. Tive's platform offers customized alerts, reporting, and analysis for both inbound and outbound shipments across various transportation modes. By enhancing supply chain transparency, Tive helps businesses improve efficiency, reduce logistics costs, and minimize manufacturing disruptions, ultimately enabling them to meet regulatory requirements effectively.

Founded in 2018, Terray Therapeutics is a biotechnology company based in Pasadena, California. It integrates experimentation and computation to enhance small molecule drug discovery, focusing on intractable diseases. The company's platform generates precise data through a rapid design-make-test-analyze cycle, enabling efficient exploration of chemical space.

Distributional develops an adaptive testing platform for enterprise AI applications. It offers tools for continuous monitoring, generating test cases, and analyzing results to ensure artificial intelligence systems function reliably and securely.

Founded in 2021, Arda Therapeutics is a biotechnology company based in the San Francisco Bay Area. It specializes in developing transformative therapeutics to eliminate pathogenic cells that drive chronic diseases and aging.

Crossover Markets Group develops a digital asset exchange platform tailored for institutional clients. Its technology enhances cryptocurrency trading speed and reduces latency, enabling seamless trading while maintaining high liquidity standards expected in traditional markets.

Vizzu is a software company that specializes in data visualization tools. Its flagship product transforms complex data into engaging, animated stories, combining data analysis and visualization steps to save users time and ensure impactful storytelling. Vizzu aims to make data analysis and presentation accessible and engaging for all, enabling data scientists and analysts to communicate complex insights clearly and effectively.

Gameto is a biotechnology company focused on advancing female reproductive health through innovative therapies. Recognizing the significant lack of treatment options in this underserved area, Gameto employs cutting-edge scientific techniques to develop solutions that enhance the quality of life for women. The company utilizes cellular engineering to create a platform that produces engineered ovarian and endometrial cell lines capable of mimicking the functions of natural cells, including hormone production and response. This platform underpins a portfolio of cellular therapeutics aimed at addressing various female reproductive diseases. Gameto's first initiative, Fertilo, targets improvements in in vitro fertilization (IVF) and egg freezing processes, striving to make them shorter, safer, and more effective. Additionally, the company is developing Deovo, an organoid model of the female reproductive system, and Ameno, a cell-based therapy designed to mitigate health issues related to primary ovarian insufficiency and menopause. Through these efforts, Gameto aims to transform the landscape of female reproductive health care.

Xaira Therapeutics is a biotechnology company that leverages artificial intelligence to revolutionize drug discovery and development. Headquartered in the San Francisco Bay Area, Xaira brings together machine learning experts, expansive data generation, and robust therapeutic product development to advance treatments for various diseases.

Nullify develops an AI-powered cybersecurity platform that automates application security tasks. This enables software engineers to focus on higher-level security work by handling tasks like vulnerability detection, triage, remediation, and threat modeling autonomously.

Treet operates a peer-to-peer resale marketplace designed to assist apparel brands in adopting circular economy practices and managing their secondhand market. By providing a platform where customers can buy and sell used items directly with one another, Treet creates additional revenue opportunities for brands while enhancing customer loyalty. The company oversees all logistics and support, allowing brands to focus on their core business while benefiting from the resale experience. This approach enables e-commerce brands to promote sustainability and take ownership of their secondhand sales, transforming used products into valuable offerings that feel new to consumers.

Anomalo is a developer of an artificial intelligence data validation tool that enables users to continuously inspect and validate data entering their warehouses. The company’s solution automatically detects and explains issues in enterprise data, facilitating seamless integration with data warehouses. By employing automated machine learning technology, Anomalo’s tool allows organizations to validate and document their data with minimal configuration, eliminating the need for users to write any code. This innovation helps companies maintain data integrity and improve the reliability of their data-driven decisions.

Ansel Health is a Delaware-based company established in 2019, developing a health insurance platform for employers to enhance employee benefits with simple supplemental health plans. It offers cash payments upon diagnosis for over 13,000 conditions, utilizing data-driven tools and automated claim processing.

Distributional develops an adaptive testing platform for enterprise AI applications. It offers tools for continuous monitoring, generating test cases, and analyzing results to ensure artificial intelligence systems function reliably and securely.

Cosmos Innovation is a technology company offering full stack software development, product design, cloud hosting, and MVP deployment services, complemented by an AI‑driven solar cell technology platform. The platform designs next‑generation perovskite–silicon tandem solar cells that are optimized through data‑driven processes, leveraging a mix of materials and methods to approach performance boundaries. By integrating software capability with energy technology, Cosmos Innovation enables clients to accelerate development of digital products and advanced solar and semiconductor technologies, reducing time and cost relative to conventional approaches.

Objective is a company that specializes in AI-native search solutions for websites and applications. It has developed a low-code platform designed to facilitate the creation of multi-search applications. Through its innovative SaaS API, Objective enables users to unlock advanced search and enrichment capabilities for various types of data, including images, text, and video. The platform allows users to conduct searches using natural language or a combination of data types, streamlining the search process and enhancing user experience.

Membrane Labs is a fintech firm that provides institutional digital asset services for OTC transactions.

Cerby, Inc. is a cybersecurity company founded in 2020 and based in Alameda, California. It specializes in developing tools and applications aimed at managing access for disconnected applications and addressing the risks associated with Shadow IT. Cerby offers a comprehensive access management platform that leverages identity providers to automate security tasks and improve identity and access management processes. This platform eliminates the reliance on manual tools and compensating controls, streamlining tasks such as offboarding and two-factor authentication enrollment. With its patent-pending access orchestration engine, Cerby provides organizations with passwordless authentication capabilities and enhanced visibility over applications that do not conform to standard protocols. By automating these processes, Cerby enables identity teams to extend access, minimize security risks, and reduce operational costs while adhering to zero trust principles.

Raincoat specializes in developing highly scalable embedded climate insurance products. It works with insurers, governments, and financial institutions to unlock new markets and enable climate resilience at scale by integrating real-time environmental data with parametric insurance models.

Building the hyperverse. We let people stream, make content, and make friends as an avatar.

Omni Network is a blockchain that supports applications in functioning across all rollups. The company creates technologies that support personal freedoms and enable global collaboration.

NetBox Labs simplifies complex network management for operators through its open and composable products. Its flagship offering, NetBox Cloud, provides an enterprise-grade SaaS version of the open-source NetBox.

Crossover Markets Group develops a digital asset exchange platform tailored for institutional clients. Its technology enhances cryptocurrency trading speed and reduces latency, enabling seamless trading while maintaining high liquidity standards expected in traditional markets.

C3 is a self-custodial exchange that combines the advantages of self-custody and decentralization with the performance and accessibility expected from traditional trading platforms. It is designed to facilitate trading in both spot and derivatives markets. The platform features a sophisticated clearing engine that supports cross-margin and cross-collateralization, allowing traders to manage their capital more efficiently by calculating margin requirements globally based on their open positions. With its focus on enhancing user experience, C3 aims to provide a secure and efficient environment for trading digital assets.

Freeform is a 3D printing company that offers metal 3D printing solutions for manufacturing firms. It deploys software‑defined, self‑sufficient metal 3D printing factories worldwide, applying advanced sensing, real‑time controls, and data‑driven learning to produce digitally verified precision parts at high speed and low cost.

Crux Informatics operates a cloud platform that connects data users with data suppliers to enable external data automation. The platform concentrates on integration, transformation, and observability of third-party data, automating the development of data pipelines, ongoing data quality validation, and management of data workflows between suppliers, consumers, and cloud environments at scale. Founded in 2017 and based in San Francisco, Crux Informatics serves as a bridge for efficient external data delivery.

Osmo is a technology company that equips computers with the ability to sense smell using advanced AI and olfactory science. Initially focused on enhancing fragrance products, Osmo's long-term goal is to improve human health and well-being through innovative applications of smell detection.

Rive is a company focused on enhancing collaboration between designers and developers through its real-time animation platform. This platform allows for the creation of animated interactive experiences that are faster, smaller, and more memory-efficient than traditional design solutions. By enabling designers to produce interactive content from concept to production, Rive simplifies the workflow and reduces the need for complex handoffs between teams. The platform facilitates the design and animation of various graphics, including animated user interfaces, characters, and icons, making it easier for creative teams to iterate freely. Overall, Rive's innovative tools streamline the development of high-quality animation for applications and games, saving businesses both time and engineering resources.

Enveda is a biotechnology company that uses AI-powered tools to explore and characterize molecules from living organisms. It aims to accelerate drug discovery by developing a comprehensive database of chemical biodiversity.

Cajal Neuroscience is a biotechnology company dedicated to discovering novel targets and therapeutics for neurodegeneration. It integrates human genetics, functional genomics, and advanced microscopy to accelerate drug discovery in this field.

Hexagon Bio, Inc. is a biotechnology company that specializes in discovering novel small molecule therapeutics by mining genomic data from fungal genomes. Founded in 2016 and headquartered in Menlo Park, California, Hexagon Bio leverages a proprietary platform that integrates data science, synthetic biology, and automation to identify and engineer drugs. The company's innovative approach focuses on developing targeted therapies for diseases with unmet medical needs by searching for evolutionarily refined molecules and their associated protein targets. Through its unique methodology, Hexagon Bio aims to uncover new medicines encoded within the global metagenome, ultimately striving to improve patient outcomes.

Flatfile is a data onboarding platform that enables developers to validate, map, and import customer data from spreadsheets into software applications. It embeds a JavaScript snippet to add an import button in web apps and provides a secure Concierge workspace for collaboration to manage data ingestion. The platform supports CSV, XLS, and TSV uploads, allows users to configure a target model for data validation, and learns over time to improve accuracy. It is API-first and widely adopted by hundreds of companies, including AstraZeneca, Square, and Sage.

Founded in 2011, Hivemind Technologies specializes in developing social video platforms and mobile applications. It offers API solutions for topics identification, sentiment analysis, language detection, news monitoring, and publisher tools such as Virato analytics and news widgets. Additionally, the company provides consulting services in data management, technology selection, automated processes design, data science team building, and machine learning algorithm application.

Xilis, Inc. is a biotechnology company founded in 2019 and based in Chapel Hill, North Carolina. The company specializes in developing next-generation organoid technologies aimed at guiding precision therapy for cancer patients and enhancing drug discovery processes. Its flagship platform, XilisµO, facilitates rapid diagnostics, personalized drug screening, and the creation of scalable patient-derived models, which support high-throughput drug discovery. By enabling both physicians and pharmaceutical companies to conduct tailored drug screenings, Xilis aims to lower costs and improve treatment outcomes for cancer patients.

Isabl is a startup focused on developing advanced diagnostic assays for cancer through whole-genome and RNA sequencing. Founded in 2020 after incubating its technology at Memorial Sloan Kettering Cancer Center from 2015 to 2019, Isabl participated in the Winter 2020 batch of Y Combinator and has attracted significant funding, including a $3 million seed round and a $2 million SBIR grant from the National Cancer Institute. The company received FDA Breakthrough Device designation in 2021, recognizing the innovative nature of its cancer diagnostic tests. Isabl's platform is designed to efficiently analyze cancer patients' genomes while ensuring data reproducibility and supporting bioinformatics operations, thereby facilitating data-driven automation for oncology centers. Led by founders Dr. Elli Papaemmanuil, Dr. Andrew Kung, and Juan Medina, Isabl's team combines expertise in precision medicine, computational biology, and software engineering, focusing on biomarker discovery and clinical decision support for pediatric and rare solid cancers.

Tive is a Boston-based startup that provides companies with end-to-end visibility into their supply chains through a sensor-driven tracking platform. The company develops a solution that combines cellular-connected trackers with cloud-based software, allowing clients to monitor, visualize, and optimize their operations in real-time. Tive's platform offers customized alerts, reporting, and analysis for both inbound and outbound shipments across various transportation modes. By enhancing supply chain transparency, Tive helps businesses improve efficiency, reduce logistics costs, and minimize manufacturing disruptions, ultimately enabling them to meet regulatory requirements effectively.

Remote is a global HR solutions provider that facilitates international hiring and payroll management for distributed teams. They offer a platform designed to help companies recruit top talent worldwide, ensuring compliance with local laws while streamlining project allocation and payments. This enables businesses to expand their workforce globally, enhancing productivity and employment opportunities.

Okteto is a cloud application development platform for Kubernetes that enables developers to quickly spin up pre-configured environments and work directly in Kubernetes. The platform provides self-service access to Kubernetes infrastructure, a developer-focused dashboard to visualize workloads, and automatic security policies, quotas, and access control for users and deployments. It supports creating secure Kubernetes namespaces, provisioning automatic HTTPS endpoints for services, and managing secrets to prevent credentials from being stored in version control. Developers can deploy applications, build remotely, and push images to the Okteto registry, with integration to the Okteto command line interface to develop inside a Kubernetes cluster. Founded in 2018 and based in San Francisco, California, Okteto focuses on accelerating cloud-native software development and improving velocity, productivity, and innovation for cloud-based applications.

Timescale develops an open-source time-series SQL database, TimescaleDB, designed for scale and complex queries. It integrates directly into query planning and execution engines to optimize performance, enabling clients to organize, store, analyze, and interpret time-series and machine data.

Kallyope Inc. is a biotechnology company based in New York City that focuses on understanding the gut-brain axis to develop innovative therapeutics and consumer products aimed at enhancing human health. Established in 2014, Kallyope employs advanced technologies, including sequencing, computational biology, neural imaging, and human genetics, to explore gut-brain biology. The company aims to address significant unmet medical needs, such as diabetes, obesity, gut disorders, inflammatory diseases, migraines, and allergies, by creating effective and user-friendly oral agents. Kallyope's team consists of experienced scientists from leading institutions, working alongside a skilled team with a strong track record in drug discovery and development. Through its research, Kallyope seeks to deliver transformative solutions that improve overall health outcomes.

Founded in 2018, Terray Therapeutics is a biotechnology company based in Pasadena, California. It integrates experimentation and computation to enhance small molecule drug discovery, focusing on intractable diseases. The company's platform generates precise data through a rapid design-make-test-analyze cycle, enabling efficient exploration of chemical space.

Radar is a location data infrastructure platform that enables app developers to create location-aware experiences. Founded in 2016 and headquartered in New York, the company provides a suite of tools, including geofencing, place detection, and location tracking, to enhance mobile applications across various industries such as retail, travel, and logistics. Radar's platform features APIs and SDKs that facilitate easy integration, allowing developers to implement contextually relevant functionalities in their applications. With a strong focus on privacy and security, Radar ensures that location data is managed responsibly. The company also offers additional APIs in private beta, including geocoding, which converts addresses to coordinates, and tools for searching geofences and calculating distances between locations.

Rift Finance operates a decentralized protocol that enhances the growth of Decentralized Autonomous Organizations (DAOs) by restructuring incentive frameworks. It enables DAOs to deploy governance tokens from their treasuries, thereby increasing token liquidity without relinquishing ownership.

Figment Networks develops open-source tools for crypto network health monitoring, enabling informed staking decisions. It focuses on networks like Tezos, Cosmos, Livepeer, and Horizen. Based in Toronto, Canada, the company was founded in 2018.

Exai Bio is a next-generation liquid biopsy company that specializes in the early diagnosis of cancer through its proprietary RNA-based platform. This innovative platform focuses on the analysis of cell-free RNA profiles, particularly orphan non-coding RNA and small RNA sequences that are typically absent in normal tissues but prevalent in tumors. By leveraging advanced artificial intelligence and machine learning algorithms, Exai Bio provides clinical insights into cancer biology, enabling healthcare professionals to identify cancer accurately and at its earliest stages. The company's approach not only enhances diagnostic precision but also informs personalized care treatments for patients.

NewtonX, Inc. is a B2B market research company that connects professional services firms and financial institutions with verified business expertise. Founded in 2016 and based in New York, NewtonX utilizes an advanced algorithm known as the NewtonX Graph, which leverages artificial intelligence to recruit the ideal audience for specific business inquiries from a vast network of over 1.1 billion professionals across 140 industries. The company ensures that every professional is thoroughly verified, enabling clients to make informed decisions. NewtonX offers a range of services, including large-scale quantitative surveys, qualitative expert interviews, long-term consultations, and tailored research plans. Through its platform, NewtonX Prime, clients gain instant access to expert insights, enhancing their competitive advantage. The company collaborates with Fortune 500 companies, top consultancies, marketers, and investors, aiming to set a new standard for truth in B2B insights.

Comet ML Inc. is a New York-based company that provides a meta machine learning platform designed to assist data science teams and individuals in building reliable machine learning models for real-world applications. The platform enables users to automatically track datasets, code changes, experimentation history, and production models, thereby enhancing efficiency, transparency, and reproducibility in the machine learning process. By allowing data scientists to maintain their preferred workflows while effectively collaborating and tracking previous work, Comet facilitates a more organized approach to experimentation. Additionally, the platform incorporates bayesian hyperparameter optimization, which streamlines the model tuning process and reduces the time typically required for manual adjustments. This comprehensive solution increases visibility into data science efforts and improves the overall effectiveness of machine learning initiatives within organizations.

Facet is a software company that empowers artists and engineers by offering innovative image editing technology. Its cloud-based platform automates tasks like intelligent layering and AI-assisted adjustments, helping creative teams enhance storytelling efficiency while maintaining consistency across visual assets.

Socure develops digital identity verification solutions using artificial intelligence and machine learning. Its platform authenticates identities in real-time from various online/offline sources, automating customer identification program (CIP), know your customer (KYC), and anti-money laundering (AML) compliance initiatives.

RightRev is a developer of an automated revenue recognition platform that enhances financial reporting accuracy and compliance for businesses. The solution integrates various processes, including customer relationship management and configure-price-quote tools, with revenue accounting and general ledger systems. This unified platform streamlines the management of revenue contracts, enabling finance professionals to track all aspects of sales and revenue reporting effectively. By facilitating adherence to accounting standards such as ASC 606 and IFRS 15, RightRev helps businesses minimize the risk of misstatements while ensuring transparency in their financial operations. The platform supports a wide range of revenue models, including subscriptions, one-time sales, services, and promotions, making it a versatile tool for sales operations and revenue management.

Anomalo is a developer of an artificial intelligence data validation tool that enables users to continuously inspect and validate data entering their warehouses. The company’s solution automatically detects and explains issues in enterprise data, facilitating seamless integration with data warehouses. By employing automated machine learning technology, Anomalo’s tool allows organizations to validate and document their data with minimal configuration, eliminating the need for users to write any code. This innovation helps companies maintain data integrity and improve the reliability of their data-driven decisions.

Nelo is a Mexico City-based company that specializes in developing a mobile application for financial transactions. Founded on April 8, 2019, Nelo offers a digital payment management platform that enables users to track their financial transactions effectively. The platform allows individuals to send and request money while providing a free virtual card with no charges for account opening. This functionality facilitates real-time payment and balance tracking, empowering users to manage their funds in an affordable and secure manner.

Eclipse Advantage is a specialized warehouse labor management company that serves the foodservice and retail sectors in North America. Operating across 55 sites in the U.S. and Canada, it offers a range of services including in-bound receiving, pallet management, and order selection. By providing outsourced supply chain workforce solutions, Eclipse Advantage enhances productivity and delivers transparency in labor expenses for warehouses and distribution centers. The company is dedicated to high-quality service, guided by its core values of serving customers, ensuring safety, and achieving success.

Sora is a low-code intelligent workflow automation and data integration tool that connects different corporate applications such as HR, IT, and other systems and data sets to provide a smarter, more user-friendly experience for employees, business owners, and HR professionals.

Replicated, Inc. is a company that specializes in providing tools for the deployment and management of third-party applications within enterprise environments. Founded in 2014 and headquartered in Culver City, California, Replicated offers a solution for organizations seeking to install and operate Software as a Service (SaaS) applications securely within their own firewalls. By enabling software vendors to deliver cloud-native applications in on-premises data centers or private clouds, Replicated enhances security and control for its clients. The company's offerings facilitate the management and support of these applications, ultimately simplifying the customer support process for businesses.

Hexagon Bio, Inc. is a biotechnology company that specializes in discovering novel small molecule therapeutics by mining genomic data from fungal genomes. Founded in 2016 and headquartered in Menlo Park, California, Hexagon Bio leverages a proprietary platform that integrates data science, synthetic biology, and automation to identify and engineer drugs. The company's innovative approach focuses on developing targeted therapies for diseases with unmet medical needs by searching for evolutionarily refined molecules and their associated protein targets. Through its unique methodology, Hexagon Bio aims to uncover new medicines encoded within the global metagenome, ultimately striving to improve patient outcomes.

Castor is an international health-tech company that provides a cloud-based clinical data platform designed to streamline the clinical trial process for researchers globally. Founded by CEO Derk Arts, MD, Ph.D., the platform is utilized by over 50,000 researchers in 90 countries, supporting more than 4,000 studies across diverse therapeutic areas, including diabetes, cardiovascular disease, rare diseases, infectious diseases, and oncology. Castor's platform facilitates the collection and analysis of extensive data from both traditional and remote trials, having reached significant milestones such as 180 million data points and 2 million enrolled patients. The company's mission is to make research data reusable, thereby enabling AI-driven clinical trials and enhancing the overall impact of data within the medical research community.

Remote is a global HR solutions provider that facilitates international hiring and payroll management for distributed teams. They offer a platform designed to help companies recruit top talent worldwide, ensuring compliance with local laws while streamlining project allocation and payments. This enables businesses to expand their workforce globally, enhancing productivity and employment opportunities.

Xilis, Inc. is a biotechnology company founded in 2019 and based in Chapel Hill, North Carolina. The company specializes in developing next-generation organoid technologies aimed at guiding precision therapy for cancer patients and enhancing drug discovery processes. Its flagship platform, XilisµO, facilitates rapid diagnostics, personalized drug screening, and the creation of scalable patient-derived models, which support high-throughput drug discovery. By enabling both physicians and pharmaceutical companies to conduct tailored drug screenings, Xilis aims to lower costs and improve treatment outcomes for cancer patients.

Founded in 2018, Terray Therapeutics is a biotechnology company based in Pasadena, California. It integrates experimentation and computation to enhance small molecule drug discovery, focusing on intractable diseases. The company's platform generates precise data through a rapid design-make-test-analyze cycle, enabling efficient exploration of chemical space.

Enveda is a biotechnology company that uses AI-powered tools to explore and characterize molecules from living organisms. It aims to accelerate drug discovery by developing a comprehensive database of chemical biodiversity.

Formlogic is an autonomous manufacturing technology company focused on delivering precision components for the space and frontier industries. By addressing the challenges of the domestic supply chain, Formlogic enhances manufacturing capabilities, allowing both novice and expert workers to achieve high levels of precision and productivity. The company's technology enables rapid turnaround times for custom machined components, with production orders completed in weeks rather than months. Additionally, Formlogic provides real-time order status updates, improving the overall customer experience. Through its innovative approach, Formlogic aims to revolutionize the manufacturing process, ensuring close tolerances and efficient production at scale.

Appia Bio is a biotechnology company dedicated to the research and development of off-the-shelf allogeneic cell therapies, with a particular focus on engineered allogeneic cell therapies for various medical indications. The company utilizes its proprietary ACUA technology platform to harness the biology of lymphocyte development, integrating chimeric antigen receptor (CAR) and T-cell receptor (TCR) gene engineering. This innovative approach allows Appia Bio to generate CAR-engineered invariant natural killer T (CAR-iNKT) cell subtypes derived from hematopoietic stem cells (HSCs). By maturing and scaling healthy stem cells into invariant T-cell therapies, Appia Bio aims to provide physicians with safe and targeted cancer treatment options, thereby expanding patient access to advanced therapeutic solutions.

Text Blaze is a productivity platform that enables users to create and utilize programmable text snippets, enhancing efficiency in typing and workflows. By allowing users to insert these snippets anywhere on the web via keyboard shortcuts, Text Blaze helps eliminate repetitive typing and reduce errors. The platform supports various snippet types, including plain text, dynamic user input, and business logic, alongside no-code integrations with other applications. Additionally, Text Blaze features collaboration tools that facilitate sharing and customizing templates, allowing teams to optimize their productivity and streamline their work processes.

Timescale develops an open-source time-series SQL database, TimescaleDB, designed for scale and complex queries. It integrates directly into query planning and execution engines to optimize performance, enabling clients to organize, store, analyze, and interpret time-series and machine data.

Wealthsimple Financial Inc. is a Toronto-based company that specializes in providing digital investment advisory services across Canada and operates additional offices in Brooklyn, New York, and London, United Kingdom. Founded in 2014, Wealthsimple offers a range of financial tools designed to help investors grow and manage their money. The company builds diversified portfolios of exchange-traded funds (ETFs) on behalf of its clients, offering accessible and affordable investment management without the high fees and account minimums typical of traditional firms. Wealthsimple also provides on-demand financial planning solutions and a hybrid savings and spending product known as Wealthsimple Cash. As of September 2020, Wealthsimple operates as a subsidiary of Purpose Advisor Solutions Inc.

Wholesale Supplies Plus is an online retailer and distributor of cosmetic ingredients and components, offering additives, colorants, fragrances, essential oils, flavor oils, cosmetic bases, soap and bath bomb molds, containers, packaging, and kits for handmade cosmetics and soap-making, based in Independence, Ohio, and serving customers who create natural and clean-label skincare, cosmetic, and aromatherapy products by providing a wide selection of raw materials and project kits to support DIY brands and individual makers.

Ansel Health is a Delaware-based company established in 2019, developing a health insurance platform for employers to enhance employee benefits with simple supplemental health plans. It offers cash payments upon diagnosis for over 13,000 conditions, utilizing data-driven tools and automated claim processing.

Boundless Immigration provides an immigration service platform that blends software tools with expert legal guidance to simplify immigration for individuals, families, and businesses. Founded in 2017 and based in Seattle, it helps users determine the right visa or citizenship path, prepare applications, and access legal support, enabling efficient and confident navigation of migration processes.

Per Diem enables local businesses to sell subscriptions online, providing them with essential marketing and fulfillment tools to foster customer loyalty and drive growth.

Facet is a software company that empowers artists and engineers by offering innovative image editing technology. Its cloud-based platform automates tasks like intelligent layering and AI-assisted adjustments, helping creative teams enhance storytelling efficiency while maintaining consistency across visual assets.

Comet ML Inc. is a New York-based company that provides a meta machine learning platform designed to assist data science teams and individuals in building reliable machine learning models for real-world applications. The platform enables users to automatically track datasets, code changes, experimentation history, and production models, thereby enhancing efficiency, transparency, and reproducibility in the machine learning process. By allowing data scientists to maintain their preferred workflows while effectively collaborating and tracking previous work, Comet facilitates a more organized approach to experimentation. Additionally, the platform incorporates bayesian hyperparameter optimization, which streamlines the model tuning process and reduces the time typically required for manual adjustments. This comprehensive solution increases visibility into data science efforts and improves the overall effectiveness of machine learning initiatives within organizations.

Tive is a Boston-based startup that provides companies with end-to-end visibility into their supply chains through a sensor-driven tracking platform. The company develops a solution that combines cellular-connected trackers with cloud-based software, allowing clients to monitor, visualize, and optimize their operations in real-time. Tive's platform offers customized alerts, reporting, and analysis for both inbound and outbound shipments across various transportation modes. By enhancing supply chain transparency, Tive helps businesses improve efficiency, reduce logistics costs, and minimize manufacturing disruptions, ultimately enabling them to meet regulatory requirements effectively.

Cylera is a healthcare IoT cybersecurity company that protects healthcare organizations from cyber threats and malware by providing a unified, asset-centric platform for managing devices, assessing risks, and detecting threats across the connected IoT environment. Founded in 2017 and based in New York, the company delivers centralized software that identifies all devices, analyzes vulnerabilities, and enables automated threat responses, supporting healthcare providers, enterprises, and government agencies in securing critical medical and operational IoT assets.

Socure develops digital identity verification solutions using artificial intelligence and machine learning. Its platform authenticates identities in real-time from various online/offline sources, automating customer identification program (CIP), know your customer (KYC), and anti-money laundering (AML) compliance initiatives.

Insitro, Inc. is a data-driven company focused on drug discovery and development, particularly targeting nonalcoholic steatohepatitis (NASH). Founded in 2018 by Daphne Koller and based in South San Francisco, California, Insitro harnesses machine learning and high-throughput biology to revolutionize the process of drug discovery. The company creates extensive functional genomic data sets and integrates them with patient data through innovative machine learning techniques. This approach allows Insitro to build predictive models that enhance target selection, streamline the design of therapeutics, and optimize drug development strategies. By addressing critical challenges in pharmaceutical research and development, Insitro aims to accelerate the delivery of new and effective treatments to patients.

Flatfile is a data onboarding platform that enables developers to validate, map, and import customer data from spreadsheets into software applications. It embeds a JavaScript snippet to add an import button in web apps and provides a secure Concierge workspace for collaboration to manage data ingestion. The platform supports CSV, XLS, and TSV uploads, allows users to configure a target model for data validation, and learns over time to improve accuracy. It is API-first and widely adopted by hundreds of companies, including AstraZeneca, Square, and Sage.

Founded in 1890, Penn Foster is a global leader in online education, offering career-focused degree programs and vocational training. It operates through Penn Foster College, Career School, and High School, providing accredited courses in allied health, business, technology, education, and select trades.

UMA is a decentralized platform aiming to facilitate global market access for financial contracts. It functions as an oracle, recording verifiable truths or data onto blockchain technology. The platform encourages dispute-based validation and maintains transparency through decentralized governance.

Smartfrog is a consumer IoT company focused on affordable DIY home security and related SaaS-enabled services. It launched the first 100% consumer IoT SaaS product in 2015, offering a DIY home security subscription starting at $7 per month with a free device. The company operates a full-stack, data-driven platform that supports multiple product areas and services across the life cycle, including Smart Home Security, Smart Locks and Access, Last-Mile In-Home Delivery, Baby and Child Care, Pet Care, and Elder and Healthcare. It serves users in numerous countries and has expanded through organic growth and acquisitions, such as Canary Connect. With a broad patent portfolio, Smartfrog pursues a mission to make modern technologies useful, easy, affordable and safe for everyone by providing accessible devices and services that connect everyday objects and people.

Tive is a Boston-based startup that provides companies with end-to-end visibility into their supply chains through a sensor-driven tracking platform. The company develops a solution that combines cellular-connected trackers with cloud-based software, allowing clients to monitor, visualize, and optimize their operations in real-time. Tive's platform offers customized alerts, reporting, and analysis for both inbound and outbound shipments across various transportation modes. By enhancing supply chain transparency, Tive helps businesses improve efficiency, reduce logistics costs, and minimize manufacturing disruptions, ultimately enabling them to meet regulatory requirements effectively.

Candu is a product experience platform founded in 2018 by Jonathan Anderson and Michele Riccardo Esposito. It enables software teams to design, refine, and personalize user interfaces for their applications, facilitating effective onboarding and user engagement. The platform features a drag-and-drop editor and an analytics suite that allows teams to customize user experiences without the need for coding. Candu's extensive UI component library empowers teams to build tailored experiences, while its analytics tools help measure the impact of these experiences on feature discovery and user adoption. Additionally, Candu supports the creation of in-product courses and just-in-time training, enabling non-technical teams to embed educational content and track user behavior, ultimately fostering product-led experiences and rapid experimentation.

Remote is a global HR solutions provider that facilitates international hiring and payroll management for distributed teams. They offer a platform designed to help companies recruit top talent worldwide, ensuring compliance with local laws while streamlining project allocation and payments. This enables businesses to expand their workforce globally, enhancing productivity and employment opportunities.

Whoop, Inc. is a Boston-based company that specializes in the development and sale of wearable fitness sensors designed for athletes to monitor their physiological metrics during workouts. Founded in 2012, Whoop provides a performance optimization system that continuously tracks key indicators such as heart rate, sleep, and recovery. The company's flagship product, the Whoop Strap 3.0, collects data around the clock, offering users insights that help balance training, minimize injuries, and enhance overall performance. In addition to the wearable device, Whoop offers a variety of apparel and accessories, including bands, tops, joggers, and hats, primarily sold online. By delivering personalized insights into physical exertion and recovery, Whoop aims to help athletes and teams maximize their potential and improve their training outcomes.

Replicated, Inc. is a company that specializes in providing tools for the deployment and management of third-party applications within enterprise environments. Founded in 2014 and headquartered in Culver City, California, Replicated offers a solution for organizations seeking to install and operate Software as a Service (SaaS) applications securely within their own firewalls. By enabling software vendors to deliver cloud-native applications in on-premises data centers or private clouds, Replicated enhances security and control for its clients. The company's offerings facilitate the management and support of these applications, ultimately simplifying the customer support process for businesses.

Wealthsimple Financial Inc. is a Toronto-based company that specializes in providing digital investment advisory services across Canada and operates additional offices in Brooklyn, New York, and London, United Kingdom. Founded in 2014, Wealthsimple offers a range of financial tools designed to help investors grow and manage their money. The company builds diversified portfolios of exchange-traded funds (ETFs) on behalf of its clients, offering accessible and affordable investment management without the high fees and account minimums typical of traditional firms. Wealthsimple also provides on-demand financial planning solutions and a hybrid savings and spending product known as Wealthsimple Cash. As of September 2020, Wealthsimple operates as a subsidiary of Purpose Advisor Solutions Inc.

Hexagon Bio, Inc. is a biotechnology company that specializes in discovering novel small molecule therapeutics by mining genomic data from fungal genomes. Founded in 2016 and headquartered in Menlo Park, California, Hexagon Bio leverages a proprietary platform that integrates data science, synthetic biology, and automation to identify and engineer drugs. The company's innovative approach focuses on developing targeted therapies for diseases with unmet medical needs by searching for evolutionarily refined molecules and their associated protein targets. Through its unique methodology, Hexagon Bio aims to uncover new medicines encoded within the global metagenome, ultimately striving to improve patient outcomes.

Recursion Pharmaceuticals is a clinical-stage biotechnology company that aims to radically improve patients’ lives by decoding biology through the integration of biology, chemistry, automation, data science, and engineering to industrialize drug discovery. The company operates a large-scale drug discovery platform built around Recursion OS, an infrastructure layer and a Map of proprietary biological and chemical data, supported by software tools and machine learning to explore biology beyond human bias and identify new therapeutic opportunities. Its platform includes ReChem for selecting and designing compounds, ReScreen and ReScreenRun for planning and automating large-scale experiments, and ReRun, ReAnalyze, and RePredict for digital signatures, data analysis, and predictive modeling of drug relationships. Founded in 2013, the company is based in Salt Lake City, Utah.

Boundless Immigration provides an immigration service platform that blends software tools with expert legal guidance to simplify immigration for individuals, families, and businesses. Founded in 2017 and based in Seattle, it helps users determine the right visa or citizenship path, prepare applications, and access legal support, enabling efficient and confident navigation of migration processes.

Castor is an international health-tech company that provides a cloud-based clinical data platform designed to streamline the clinical trial process for researchers globally. Founded by CEO Derk Arts, MD, Ph.D., the platform is utilized by over 50,000 researchers in 90 countries, supporting more than 4,000 studies across diverse therapeutic areas, including diabetes, cardiovascular disease, rare diseases, infectious diseases, and oncology. Castor's platform facilitates the collection and analysis of extensive data from both traditional and remote trials, having reached significant milestones such as 180 million data points and 2 million enrolled patients. The company's mission is to make research data reusable, thereby enabling AI-driven clinical trials and enhancing the overall impact of data within the medical research community.

Founded in 2019, Odeko is a software platform designed to help small businesses, particularly cafes and bakeries, manage inventory efficiently. Its key features include inventory tracking, supply chain management, sales reporting, and integration with payment systems and delivery services.

Brella is a networking platform for events, conferences and livestreams that helps professionals discover and connect with high-value contacts. The platform relies on a matchmaking algorithm, often AI-powered, to guide attendees to relevant people, opportunities, and conversations at the right time and place. Based in Jyväskylä, Finland, Brella aims to simplify networking and enable attendees to build meaningful business relationships during live events, conferences, and streams, facilitating face-to-face interactions and timely connections.

Ansel Health is a Delaware-based company established in 2019, developing a health insurance platform for employers to enhance employee benefits with simple supplemental health plans. It offers cash payments upon diagnosis for over 13,000 conditions, utilizing data-driven tools and automated claim processing.

Scaling AI to the Real World.

Flatfile is a data onboarding platform that enables developers to validate, map, and import customer data from spreadsheets into software applications. It embeds a JavaScript snippet to add an import button in web apps and provides a secure Concierge workspace for collaboration to manage data ingestion. The platform supports CSV, XLS, and TSV uploads, allows users to configure a target model for data validation, and learns over time to improve accuracy. It is API-first and widely adopted by hundreds of companies, including AstraZeneca, Square, and Sage.

Insitro, Inc. is a data-driven company focused on drug discovery and development, particularly targeting nonalcoholic steatohepatitis (NASH). Founded in 2018 by Daphne Koller and based in South San Francisco, California, Insitro harnesses machine learning and high-throughput biology to revolutionize the process of drug discovery. The company creates extensive functional genomic data sets and integrates them with patient data through innovative machine learning techniques. This approach allows Insitro to build predictive models that enhance target selection, streamline the design of therapeutics, and optimize drug development strategies. By addressing critical challenges in pharmaceutical research and development, Insitro aims to accelerate the delivery of new and effective treatments to patients.

Ansel Health is a Delaware-based company established in 2019, developing a health insurance platform for employers to enhance employee benefits with simple supplemental health plans. It offers cash payments upon diagnosis for over 13,000 conditions, utilizing data-driven tools and automated claim processing.

Xilis, Inc. is a biotechnology company founded in 2019 and based in Chapel Hill, North Carolina. The company specializes in developing next-generation organoid technologies aimed at guiding precision therapy for cancer patients and enhancing drug discovery processes. Its flagship platform, XilisµO, facilitates rapid diagnostics, personalized drug screening, and the creation of scalable patient-derived models, which support high-throughput drug discovery. By enabling both physicians and pharmaceutical companies to conduct tailored drug screenings, Xilis aims to lower costs and improve treatment outcomes for cancer patients.

Comet ML Inc. is a New York-based company that provides a meta machine learning platform designed to assist data science teams and individuals in building reliable machine learning models for real-world applications. The platform enables users to automatically track datasets, code changes, experimentation history, and production models, thereby enhancing efficiency, transparency, and reproducibility in the machine learning process. By allowing data scientists to maintain their preferred workflows while effectively collaborating and tracking previous work, Comet facilitates a more organized approach to experimentation. Additionally, the platform incorporates bayesian hyperparameter optimization, which streamlines the model tuning process and reduces the time typically required for manual adjustments. This comprehensive solution increases visibility into data science efforts and improves the overall effectiveness of machine learning initiatives within organizations.