Essex Woodlands was founded in 1985 with the establishment of Essex Venture Fund I, LP. Since 1985, the Partnership has raised seven additional funds with nearly $2.5 billion under management, making Essex Woodlands one of the world's largest and most established healthcare venture capital firms. The team is comprised of 23 professionals with principal offices in Palo Alto, Houston, New York and London. This team brings over 300 years of collective healthcare experience. For over 20 years, the firm has maintained its dedicated focus to diversified healthcare investing—primarily serving as lead investor in the founding or the critical financings of over 100 healthcare companies in pharmaceutical, biotechnology, medical device, services and information technology sectors. In addition to its long-standing commitment to early stage companies, the firm has over a decade of experience as a leading late-stage healthcare investor, which includes mature venture, growth equity and PIPE investment opportunities.
Cardiva Medical, Inc. is a medical device company that specializes in vascular access management products aimed at facilitating the body's natural healing process after percutaneous catheterization procedures. Its product lineup includes VASCADE VCS, a bioabsorbable femoral access closure system that promotes rapid hemostasis and reduces complications. Additionally, Cardiva offers the Catalyst manual compression assistance device, which supports temporary hemostasis and improves coagulation for patients needing manual compression. The company also manufactures VASCADE MVP, a vascular closure system for multi-site venous closure during electrophysiology procedures such as cardiac ablation. Founded in 2002 and headquartered in Santa Clara, California, Cardiva Medical serves physicians and cardiac centers across the United States.
TissueTech, Inc. specializes in developing regenerative products derived from human amniotic and umbilical cord tissues for applications in ophthalmology, optometry, musculoskeletal care, and wound management. The company offers cryopreserved amniotic membranes and umbilical cord products, utilizing proprietary technologies such as CryoTek, which preserves the biological integrity of placental tissues, and SteriTek, which ensures shelf stability while maintaining natural hydration. Founded in 1997 and based in Miami, Florida, TissueTech focuses on providing enhanced regenerative healing solutions that allow physicians to improve patient outcomes in various medical fields.
Xenex is a company focused on reducing healthcare-associated infections (HAIs) through its advanced ultraviolet disinfection technology. Founded in 2009 and based in San Antonio, Texas, Xenex has developed a portable device that utilizes pulsed xenon UV light to eliminate harmful microorganisms in hospital environments. Since launching its disinfection system in June 2010, the company’s devices have been integrated into infection control protocols in nearly three hundred hospitals across the United States. By effectively reducing the bacterial load that contributes to HAIs, Xenex aims to enhance patient safety and safeguard healthcare staff, ultimately striving to save lives and alleviate suffering in healthcare settings.
Prolacta Bioscience Inc. develops and produces standardized human milk-based nutritional products for premature and critically ill infants in the neonatal intensive care unit (NICU). It offers human milk-based human milk fortifiers; human milk caloric fortifiers; standardized human milk; a ready-to-feed human milk-based premature infant formula; and solutions for early/trophic feeds and full feeds. The company was incorporated in 1999 and is headquartered in Duarte, California.
Metabolon is a technology company, develops analytical methods and software for biomarker discovery using metabolomics. It offers a biochemical profiling platform that analyzes and identifies biochemicals in the research of pharmaceutical, biotech, agriculture, cosmetic, and consumer products. Metabolon provides a unique, real-time fingerprint of biological system to reveal novel discoveries and realize the promise of precision medicine.
The company can deliver an instantaneous snapshot of the entire physiology of a living being at a discreet point in time, as well as identify changes in that system brought about the impact of the disease, medical intervention, diet, or the environment. This deep and comprehensive view of the metabolome provides biological insights that cannot be revealed through any other research methodology, enabling life sciences researchers and drug developers to discover answers to some of biology’s most difficult questions.
Metabolon was founded in 2000 and headquartered in Durham, North Carolina.
Suneva Medical, Inc. is a medical technology company specializing in the development, manufacturing, and commercialization of innovative products for the dermatology and aesthetic markets. Its flagship product, Bellafill, is a unique dermal filler that has five-year safety and efficacy data, making it the only filler approved for the correction of facial acne scars. The company also offers Puregraft, designed to enhance fat graft retention, and Suneva Medical HD platelet-rich plasma, which optimizes platelet concentrate capture. Additionally, Suneva Medical provides Silhouette InstaLift resorbable sutures for cosmetic facial procedures. Founded in 2008 and based in San Diego, California, the company aims to deliver high patient satisfaction through its differentiated product offerings, which present significant opportunities for its practice partners.
Kona Medical, Inc. specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. The company's flagship product, Surround Sound, employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation, offering a less invasive alternative to traditional methods for managing drug-resistant hypertension. Founded in 2009 by Dr. Michael Gertner, the company emerged from the integration of his innovations with the assets of Therus Corporation, a predecessor in therapeutic focused ultrasound. Based in Issaquah, Washington, Kona Medical is dedicated to addressing the health risks associated with high blood pressure through advanced technology.
AxoGen, Inc. engages in the development of treatment options for the repair of peripheral nerve injuries. It offers AVANCE Nerve Graft, a human allograft nerve that is used for the repair, replacement, and reconstruction of damaged peripheral nerves. The company accepts orders through phone, fax, or email. It serves surgeons. AxoGen has a strategic tissue recovery partnership with American Tissue Services Foundation (ATSF). The company was founded in 2002 and is based in Alachua, Florida.
QSpex Technologies, Inc., an optical service center, offers finished eyewear in the United States. It offers high impact, single vision, progressive, anti reflective, photochromic, and polar lenses. The company was founded in 2007 and is based in Alpharetta, Georgia. On June 8, 2020, QSpex Technologies, Inc. filed a voluntary petition for liquidation under Chapter 7 in the U.S. Bankruptcy Court for the District of Delaware.
PreCision Dermatology is a fully-integrated dermatology company with a mission to deliver innovative therapies to doctors and patients that demonstrably improve the care of skin. PreCision Dermatology is expanding rapidly through internally generated innovation, acquisitions, in-licensing, and co-marketing opportunities.
Revance Therapeutics, Inc. is a biotechnology company focused on the development, manufacture, and commercialization of neuromodulators for aesthetic and therapeutic uses. The company’s lead product, DaxibotulinumtoxinA for injection (DAXI), is undergoing clinical trials for various conditions, including glabellar lines, cervical dystonia, adult upper limb spasticity, and chronic migraine. In addition, DAXI is being evaluated for cosmetic applications such as forehead lines and lateral canthal lines. Revance is also developing DaxibotulinumtoxinA Topical for both therapeutic and aesthetic purposes, and it is working on a biosimilar to BOTOX in collaboration with Mylan. Founded in 1999 and originally known as Essentia Biosystems, the company is headquartered in Newark, California.
Catalyst Biosciences is a drug discovery and development company. It is creating novel catalytic biopharmaceutical products based on engineered human proteases. The mission is to establish protease therapeutics as a new therapeutic platform comparable in depth and scope to antibody pharmaceuticals. The Company is developing proteases for the treatment of a broad range of diseases with a strong focus on hemostasis and inflammation.
Founded in 1997, the company is headquartered in South San Francisco, California.
Yantai Beacon Medical Technology Co., Ltd., founded in 2012 and headquartered in Yantai, China, specializes in the manufacture of medical equipment, notably medical gas systems and oxygen supply systems. The company also offers purification engineering services. Originally established in 1999 as Yantai Beacon Group Company Limited, it operates as a subsidiary of Bright Future (Hong Kong) Holding Ltd. Through its innovative solutions, Yantai Beacon Medical aims to enhance healthcare delivery by providing essential medical technologies.
Kona Medical, Inc. specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. The company's flagship product, Surround Sound, employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation, offering a less invasive alternative to traditional methods for managing drug-resistant hypertension. Founded in 2009 by Dr. Michael Gertner, the company emerged from the integration of his innovations with the assets of Therus Corporation, a predecessor in therapeutic focused ultrasound. Based in Issaquah, Washington, Kona Medical is dedicated to addressing the health risks associated with high blood pressure through advanced technology.
BreatheAmerica provides treatment facilities for patients suffering from breathing and other related allergic problems. BreatheAmerica is a company dedicated to improving how healthcare services are delivered to patients who suffer from chronic airway diseases - allergy, sinusitis, asthma, and other related diseases - with the goal of improving outcomes, reducing healthcare expenditures, and delivering an exceptional, differentiated patient experience. Joseph C. Hutts and Derril Reeves formed the company in Nashville, Tennesee in 2006.
Catalyst Biosciences is a drug discovery and development company. It is creating novel catalytic biopharmaceutical products based on engineered human proteases. The mission is to establish protease therapeutics as a new therapeutic platform comparable in depth and scope to antibody pharmaceuticals. The Company is developing proteases for the treatment of a broad range of diseases with a strong focus on hemostasis and inflammation.
Founded in 1997, the company is headquartered in South San Francisco, California.
QSpex Technologies, Inc., an optical service center, offers finished eyewear in the United States. It offers high impact, single vision, progressive, anti reflective, photochromic, and polar lenses. The company was founded in 2007 and is based in Alpharetta, Georgia. On June 8, 2020, QSpex Technologies, Inc. filed a voluntary petition for liquidation under Chapter 7 in the U.S. Bankruptcy Court for the District of Delaware.
Kona Medical, Inc. specializes in developing a non-invasive ultrasound-based therapy system aimed at treating hypertension and related disorders. The company's flagship product, Surround Sound, employs ultrasound imaging to precisely deliver focused ultrasound energy for renal denervation, offering a less invasive alternative to traditional methods for managing drug-resistant hypertension. Founded in 2009 by Dr. Michael Gertner, the company emerged from the integration of his innovations with the assets of Therus Corporation, a predecessor in therapeutic focused ultrasound. Based in Issaquah, Washington, Kona Medical is dedicated to addressing the health risks associated with high blood pressure through advanced technology.
NeoVista Inc is dedicated to the development of medical technologies that help to advance the treatment of wet age-related macular degeneration (AMD). Wet AMD affects more than 5 million people around the world and is a major cause of blindness in men and women over the age of 50. The unique technology being developed by NeoVista continues to show promise in clinical studies. It is our goal to help improve the quality of care and reduce the burden of this destructive condition on patients, physicians, and the healthcare system.
Bioventus LLC develops and/or markets orthobiologic solutions for bone fusion and osteoarthritis. Its active healing therapies product line supports accelerated and more complete healing of bone fractures, and treats the chronic pain associated with osteoarthritis; and bone healing solutions work to enhance the body’s natural healing process. The company also provides injection therapies that treat osteoarthritic joints relieve pain and help bring mobility back to the patient; and surgical orthobiologics. Its products are available through a network of distributors. The company was incorporated in 2011 and is based in Durham, North Carolina. Bioventus LLC operates as a subsidiary of Bioventus Inc.
IntegenX Inc. specializes in developing human DNA identification solutions, utilizing advanced fluidics, optics, and biochemistry to create automated systems for DNA-based human identity testing. The company’s flagship product, the RapidHIT System, provides a sample-to-answer solution for STR-based human identification, generating standardized DNA profiles from buccal swabs and other samples. Additionally, IntegenX offers the RapidHIT GlobalFiler Express Kit for processing various swab types and crime scene samples, as well as RapidHIT PowerPlex 16 HS kits. The company distributes its products through various international channels, including markets in Europe and Asia. Founded in 2003 and based in Pleasanton, California, IntegenX was previously known as Microchip Biotechnologies, Inc. and rebranded in 2010. As of 2018, it operates as a subsidiary of Thermo Fisher Scientific Inc.
Biotoscana Group (GBT) is a fast growing biopharmaceutical company in Latin America. The group was established through the merger of two leading specialty pharmaceutical companies, each with over 25 years experience in their respective markets: Biotoscana, founded in 1984, and United Medical, founded in 1987, sells leading brands GBT fields highly complex genetic disorders, rare diseases, oncology, hematology and specialized treatments, and has long-standing partnerships with leading global players in the pharmaceutical field.
BreatheAmerica provides treatment facilities for patients suffering from breathing and other related allergic problems. BreatheAmerica is a company dedicated to improving how healthcare services are delivered to patients who suffer from chronic airway diseases - allergy, sinusitis, asthma, and other related diseases - with the goal of improving outcomes, reducing healthcare expenditures, and delivering an exceptional, differentiated patient experience. Joseph C. Hutts and Derril Reeves formed the company in Nashville, Tennesee in 2006.
Entellus Medical, operating as Stryker ENT, specializes in developing and marketing minimally invasive products for the treatment of chronic sinusitis, eustachian tube dysfunction, and nasal airway obstruction. The company offers a range of innovative solutions, including the XprESS ENT dilation system, which provides versatility in balloon dilation procedures; the custom-fit XprESS LoProfile; and the LATERA absorbable nasal implant, which supports nasal cartilage. Additionally, Entellus Medical provides various surgical instruments and endoscopic imaging solutions designed to enhance treatment outcomes for ear, nose, and throat physicians and their patients. The FinESS Sinus Treatment is a notable product that allows for effective treatment of chronic rhinosinusitis with minimal invasiveness, typically performed under local anesthesia. Founded in 2006 and headquartered in Plymouth, Minnesota, Entellus Medical collaborates with researchers and clinicians to address the specific needs of patients and healthcare providers. The company operates as a subsidiary of Stryker Corporation.
Revance Therapeutics, Inc. is a biotechnology company focused on the development, manufacture, and commercialization of neuromodulators for aesthetic and therapeutic uses. The company’s lead product, DaxibotulinumtoxinA for injection (DAXI), is undergoing clinical trials for various conditions, including glabellar lines, cervical dystonia, adult upper limb spasticity, and chronic migraine. In addition, DAXI is being evaluated for cosmetic applications such as forehead lines and lateral canthal lines. Revance is also developing DaxibotulinumtoxinA Topical for both therapeutic and aesthetic purposes, and it is working on a biosimilar to BOTOX in collaboration with Mylan. Founded in 1999 and originally known as Essentia Biosystems, the company is headquartered in Newark, California.
NeoVista Inc is dedicated to the development of medical technologies that help to advance the treatment of wet age-related macular degeneration (AMD). Wet AMD affects more than 5 million people around the world and is a major cause of blindness in men and women over the age of 50. The unique technology being developed by NeoVista continues to show promise in clinical studies. It is our goal to help improve the quality of care and reduce the burden of this destructive condition on patients, physicians, and the healthcare system.
Symphogen A/S is a late-stage biopharmaceutical company based in Ballerup, Denmark, with an operational presence in Somerville, New Jersey. The company specializes in developing innovative therapies for cancer and other significant diseases, focusing on recombinant polyclonal antibodies (rpAb). Its product pipeline includes Sym004, a mixture of two monoclonal antibodies targeting different epitopes of EGFR for metastatic colorectal cancer and glioblastoma; Sym013, which inhibits EGFR, HER2, and HER3; and Sym015, aimed at eliminating the MET receptor. Additionally, Sym021 is designed to block PD1, while Sym009 is a monoclonal antibody conjugated to an antibiotic for treating resistant strains of staphylococcus aureus. Symphogen targets various epithelial cancer indications, including colorectal, lung, brain, breast, pancreatic, and head and neck cancers. Founded in 2000, Symphogen continues to advance its mission in the biopharmaceutical sector.
Endologix, Inc. is a medical device company that specializes in the development and manufacturing of minimally invasive treatments for abdominal aortic aneurysms (AAA). The company's product portfolio includes several endovascular aneurysm repair (EVAR) systems, such as the AFX endovascular AAA system, which features a minimally invasive delivery mechanism, and the VELA Proximal Endograft, designed for specific aortic neck anatomies. Additionally, Endologix offers the Ovation abdominal stent graft system and the Nellix endovascular aneurysm sealing (EVAS) system, which effectively seals aneurysms while ensuring adequate blood flow to the legs. The company also provides extensions and accessories to customize and facilitate the delivery of its devices. Endologix markets its products through a direct sales force and a network of third-party distributors and agents. Established in 1992 and based in Irvine, California, Endologix has evolved from its original name, Radiance Medical Systems, Inc., to focus solely on addressing critical aortic-related health issues.
ProteinSimple is part of the Protein Platforms division of Bio-Techne (NASDAQ: TECH). They rethinking protein tools and helping thousands of researchers around the world resolve their protein analysis problems so they can reveal new insight into proteins and their role in disease. Their wide-ranging portfolio of tools includes everything from immunoassay systems that quantify protein expression to systems that probe the structure and purity of protein-based therapeutics.
Accumetrics is a privately-held company based in San Diego, California, specializing in the development, manufacturing, and marketing of the VerifyNow System. This system comprises a comprehensive suite of assays designed for the assessment of platelet function, which is crucial in various medical applications, particularly in cardiovascular care. Founded in 1996, Accumetrics was initially sold to Radiometer in 2000 but was repurchased by its management and investors in 2003. The company continues to focus on providing essential tools for healthcare professionals to improve patient outcomes through effective monitoring of platelet activity.
Complete Genomics is a developer of a DNA sequencing platform that focuses on human genome sequencing and analysis. The company offers high-quality and affordable DNA sequencing services, which facilitate large-scale research into the genetic mechanisms that influence drug responses and complex diseases. By integrating proprietary sequencing technology with advanced informatics and data management software, Complete Genomics provides customers with readily usable data for genome-based research. This combination of innovative technology and a disruptive approach positions the company to significantly impact the field of DNA sequencing.
Velcera is a specialty pharmaceutical company with a passion for assuring pets receive the medicines they need to support excellent overall health. At Velcera, they are dedicated to developing innovative, high-quality products for the pet health market. They comply with the highest standards of practice through all phases, from development to manufacturing to marketing.
Molecular Partners AG is a clinical-stage biopharmaceutical company based in Schlieren, Switzerland, focused on developing innovative therapies for serious diseases. The company is advancing a new class of small protein therapeutics known as DARPin, exemplified by its lead candidate Abicipar, which is undergoing Phase III clinical trials for wet age-related macular degeneration and diabetic macular edema. Other candidates in development include MP0250, aimed at enhancing standard treatments for multiple myeloma, and MP0274, currently in Phase I trials for HER2-positive solid tumors. Additionally, MP0310 is being evaluated in Phase I trials for immuno-oncology applications, while MPO317 and Peptide-MHC are designed to activate immune responses within tumors. Molecular Partners collaborates with notable partners, including Allergan and Amgen, and is engaged in a program to develop anti-COVID-19 therapeutics in partnership with AGC Biologics. Founded in 2004, the company aims to significantly improve disease management through its cutting-edge therapeutic approaches.
Entellus Medical, operating as Stryker ENT, specializes in developing and marketing minimally invasive products for the treatment of chronic sinusitis, eustachian tube dysfunction, and nasal airway obstruction. The company offers a range of innovative solutions, including the XprESS ENT dilation system, which provides versatility in balloon dilation procedures; the custom-fit XprESS LoProfile; and the LATERA absorbable nasal implant, which supports nasal cartilage. Additionally, Entellus Medical provides various surgical instruments and endoscopic imaging solutions designed to enhance treatment outcomes for ear, nose, and throat physicians and their patients. The FinESS Sinus Treatment is a notable product that allows for effective treatment of chronic rhinosinusitis with minimal invasiveness, typically performed under local anesthesia. Founded in 2006 and headquartered in Plymouth, Minnesota, Entellus Medical collaborates with researchers and clinicians to address the specific needs of patients and healthcare providers. The company operates as a subsidiary of Stryker Corporation.
Xanodyne Pharmaceuticals, Inc. operates as an integrated specialty pharmaceutical company that offers developing and commercializing products in women’s healthcare and pain management in the United States.The company was formerly known as Xanodyne Pharmacal, Inc. and changed the name to Xanodyne Pharmaceuticals, Inc. in February, 2004. Xanodyne Pharmaceuticals, Inc. was incorporated in 2000 and is based in Newport, Kentucky.
Accumetrics is a privately-held company based in San Diego, California, specializing in the development, manufacturing, and marketing of the VerifyNow System. This system comprises a comprehensive suite of assays designed for the assessment of platelet function, which is crucial in various medical applications, particularly in cardiovascular care. Founded in 1996, Accumetrics was initially sold to Radiometer in 2000 but was repurchased by its management and investors in 2003. The company continues to focus on providing essential tools for healthcare professionals to improve patient outcomes through effective monitoring of platelet activity.
Complete Genomics is a developer of a DNA sequencing platform that focuses on human genome sequencing and analysis. The company offers high-quality and affordable DNA sequencing services, which facilitate large-scale research into the genetic mechanisms that influence drug responses and complex diseases. By integrating proprietary sequencing technology with advanced informatics and data management software, Complete Genomics provides customers with readily usable data for genome-based research. This combination of innovative technology and a disruptive approach positions the company to significantly impact the field of DNA sequencing.
Oraya Therapeutics focuses on developing noninvasive, robotically controlled treatments for inflammatory and neovascular diseases of the eye. The company is currently testing its first application of the IRay system, which aims to provide innovative solutions for eye-related conditions. By leveraging advanced technology, Oraya Therapeutics seeks to improve patient outcomes and enhance the management of ocular diseases.
Chroma Therapeutics Ltd. develops novel small molecule drugs based on chromatin biology and novel cell accumulation approaches for targeted cancer and inflammation treatments. Its products include Tosedostat, an oral aminopeptidase inhibitor; CHR-3996, an optimized histone deacetylase inhibitor for the treatment of cancer; and CHR-2845, a targeted solution for haemotological malignancies. The company was founded in 2000 and is based in Abingdon, United Kingdom.
NeoVista Inc is dedicated to the development of medical technologies that help to advance the treatment of wet age-related macular degeneration (AMD). Wet AMD affects more than 5 million people around the world and is a major cause of blindness in men and women over the age of 50. The unique technology being developed by NeoVista continues to show promise in clinical studies. It is our goal to help improve the quality of care and reduce the burden of this destructive condition on patients, physicians, and the healthcare system.
Symphogen A/S is a late-stage biopharmaceutical company based in Ballerup, Denmark, with an operational presence in Somerville, New Jersey. The company specializes in developing innovative therapies for cancer and other significant diseases, focusing on recombinant polyclonal antibodies (rpAb). Its product pipeline includes Sym004, a mixture of two monoclonal antibodies targeting different epitopes of EGFR for metastatic colorectal cancer and glioblastoma; Sym013, which inhibits EGFR, HER2, and HER3; and Sym015, aimed at eliminating the MET receptor. Additionally, Sym021 is designed to block PD1, while Sym009 is a monoclonal antibody conjugated to an antibiotic for treating resistant strains of staphylococcus aureus. Symphogen targets various epithelial cancer indications, including colorectal, lung, brain, breast, pancreatic, and head and neck cancers. Founded in 2000, Symphogen continues to advance its mission in the biopharmaceutical sector.
Catalyst Biosciences is a drug discovery and development company. It is creating novel catalytic biopharmaceutical products based on engineered human proteases. The mission is to establish protease therapeutics as a new therapeutic platform comparable in depth and scope to antibody pharmaceuticals. The Company is developing proteases for the treatment of a broad range of diseases with a strong focus on hemostasis and inflammation.
Founded in 1997, the company is headquartered in South San Francisco, California.
Nellix has developed an original device designed to address and expand the indication for the less invasive treatment of Abdominal Aortic Aneurysms (AAAs) and Thoratic Aortic Aneurysms (TAAs). Enabling the treatment of all aneurysms with a low profiles delivery system and innovative endograft, the Nellix device has the potential to double the market size for Endovascular Aneurysms Repair (EVAR), which exceeded $800M in 2008 with a 16% CAGR (Med Tech Insight).
Accumetrics is a privately-held company based in San Diego, California, specializing in the development, manufacturing, and marketing of the VerifyNow System. This system comprises a comprehensive suite of assays designed for the assessment of platelet function, which is crucial in various medical applications, particularly in cardiovascular care. Founded in 1996, Accumetrics was initially sold to Radiometer in 2000 but was repurchased by its management and investors in 2003. The company continues to focus on providing essential tools for healthcare professionals to improve patient outcomes through effective monitoring of platelet activity.
Oraya Therapeutics focuses on developing noninvasive, robotically controlled treatments for inflammatory and neovascular diseases of the eye. The company is currently testing its first application of the IRay system, which aims to provide innovative solutions for eye-related conditions. By leveraging advanced technology, Oraya Therapeutics seeks to improve patient outcomes and enhance the management of ocular diseases.
ATS Medical
Funding Round in 2008
ATS Medical is a medical device manufacturer specializing in cardiovascular surgery products. ATS is a global company with product sales in more than 40 countries across the globe and superior product performance in more than 80,000 mechanical heart valves implanted to date. The ATS Open Pivot® Heart Valve utilizes a unique design specifically intended to offer advantages to the surgeon and improved quality of life to the patient. Instead of cavities in the hinge area, which is the case in all other bileaflet heart valves, The ATS Open Pivot® Heart Valve has open pivots. This enables the leaflets to pivot on smooth spheres that project gently into the bloodstream. The unique configuration eliminates cavities and stagnant areas where blood may collect and clot. For more information about The ATS Open Pivot® Heart Valve, please visit the expanded discussion for patients, physicians, or investors.
Revance Therapeutics, Inc. is a biotechnology company focused on the development, manufacture, and commercialization of neuromodulators for aesthetic and therapeutic uses. The company’s lead product, DaxibotulinumtoxinA for injection (DAXI), is undergoing clinical trials for various conditions, including glabellar lines, cervical dystonia, adult upper limb spasticity, and chronic migraine. In addition, DAXI is being evaluated for cosmetic applications such as forehead lines and lateral canthal lines. Revance is also developing DaxibotulinumtoxinA Topical for both therapeutic and aesthetic purposes, and it is working on a biosimilar to BOTOX in collaboration with Mylan. Founded in 1999 and originally known as Essentia Biosystems, the company is headquartered in Newark, California.
Corium International, Inc. is a biopharmaceutical company specializing in the development, manufacture, and commercialization of specialty pharmaceutical products that utilize transdermal and transmucosal delivery systems. The company offers several products, including a clonidine transdermal delivery system for hypertension, fentanyl patches for chronic pain management, and Crest Whitestrips for teeth whitening. Its product pipeline features innovative therapies, such as Twirla, a hormonal contraceptive patch, and a transdermal system for severe osteoporosis. Additionally, Corium is developing transdermal systems for Alzheimer's disease, psychiatric disorders, and motion sickness. The company collaborates with various pharmaceutical partners to advance its product offerings. Established in 1995, Corium International is headquartered in Menlo Park, California, and operates with a focus on enhancing therapeutic outcomes through advanced drug delivery technologies.
Orthovita
Post in 2007
Orthovita is a spine and orthopedic biosurgery company that manufactures and markets orthobiologic and biosurgery products. Its orthobiologics platform offers products for the fusion, regeneration, and fixation of human bones; and the biosurgery platform provides products for controlling intra-operative bleeding. Orthovita sells its products directly, as well as through non-stocking distributors and independent sales agents in the United States; and directly and through independent stocking distributors internationally. The company has strategic partnerships with Kensey Nash Corporation, Angiotech Pharmaceuticals, and Medafor. It was founded in 1992 and is based in Malvern, Pennsylvania.
Xanodyne Pharmaceuticals, Inc. operates as an integrated specialty pharmaceutical company that offers developing and commercializing products in women’s healthcare and pain management in the United States.The company was formerly known as Xanodyne Pharmacal, Inc. and changed the name to Xanodyne Pharmaceuticals, Inc. in February, 2004. Xanodyne Pharmaceuticals, Inc. was incorporated in 2000 and is based in Newport, Kentucky.
Horizon Therapeutics operates as a biopharmaceutical company. It focuses on the development of prescription drugs for mild to moderate pain relief and arthritis. The company's product candidates include HZT-501, a proprietary fixed-dose combination formulation of NSAID and ibuprofen; and HZT-602, a combination oral drug product consisting of naproxen and famotidine. Horizon Therapeutics is based in Northbrook, Illinois, and was founded in 2005.
Oraya Therapeutics focuses on developing noninvasive, robotically controlled treatments for inflammatory and neovascular diseases of the eye. The company is currently testing its first application of the IRay system, which aims to provide innovative solutions for eye-related conditions. By leveraging advanced technology, Oraya Therapeutics seeks to improve patient outcomes and enhance the management of ocular diseases.
Millennium Pharmacy Systems is a pharmacy services provider to the long-term care industry. Offering a new approach to pharmacy services, Millennium delivers on the promise of "the right drug, for the right patient, at the right time, for the right price" so its customers can deliver the best patient care while reducing costs, and more easily meeting compliance demands. Only Millennium combines Just-In-Time Dispensing with electronic medication and treatment ordering, administration, documentation, and reporting. Millennium backs up the commitment with delivery timeliness and medication accuracy customer guarantees. Millennium is headquartered in Chicago, Illinois.
StrataGent Life Sciences, Inc. is a specialty drug therapy company developing painless, non-invasive versions of therapies that would otherwise be injected. Its products are based on its proprietary microjet technology, which delivers large and small therapeutic molecules without a device penetrating into or through the skin. In May of 2004, StrataGent received a $2 million award from the Advanced Technology Program (ATP) at the National Institute of Standards and Technology to support the development of the StrataGent microjet technology.
Founded in March 2015, EUSA Pharma is a newly-established, profitable specialty pharmaceutical company with global reach from its headquarters in the UK and its commercial operations across Europe and the USA. Currently, EUSA Pharma has a portfolio of five approved as well as several named-patient specialty hospital products, including: Caphosol®, Xenazine®, Collatamp®, Custodiol® and Fomepizole® EUSA submitted the MAA for FOTIVDA (tivozanib HCL) as first line therapy for RCC in Q1 of 2016. EUSA Pharma has ambitious plans to expand its portfolio through acquisition and in-licensing and is led by an experienced management team with a strong record of building successful specialty pharmaceutical companies. The EUSA Pharma business is supported by significant funding raised from leading life science investor Essex Woodlands. In addition to direct commercial operations across the EU and US, EUSA Pharma also has a wide distribution network of commercial partners in Europe, the Middle East, Asia and Latin America and makes products available in approximately 40 countries across the world through this broad international platform.
Alaunos Therapeutics is a clinical-stage biopharmaceutical company focused on developing immuno-oncology therapies aimed at treating heterogeneous solid tumors. The company utilizes innovative platform technologies, including the Sleeping Beauty system, which enables the genetic engineering of immune cells to enhance T-cell functionality for cancer treatment. Alaunos is advancing several therapies, notably Ad-RTS-hIL-12 combined with veledimex, which is currently in Phase 2 trials for recurrent glioblastoma multiforme. Additionally, the company is exploring chimeric antigen receptor (CAR) T-cell and T-cell receptor T-cell therapies, leveraging collaborations with renowned institutions such as MD Anderson Cancer Center. The RheoSwitch Therapeutic System is another key technology employed by Alaunos, allowing for precise modulation of gene expression to improve cancer treatment outcomes. Founded in 1998 and based in Boston, Massachusetts, Alaunos is committed to advancing its portfolio of immuno-oncology solutions to address unmet medical needs in cancer care.
Ception Therapeutics is a biopharmaceutical company focused on the discovery and development of novel products to address areas of unmet medical need. Ception was founded by experienced pharmaceutical executives in order to develop and commercialize therapeutics in areas of significant unmet medical need.
Healthcare Brands International Ltd
Venture Round in 2007
Healthcare Brands International (HBI) is a new company helping to turn innovative medical product technology into successful consumer brands.
Global Cord Blood Corporation operates in the People's Republic of China, specializing in umbilical cord blood storage and related services. The company offers testing, processing, and long-term storage of cord blood for expectant parents, as well as processing and storage of donated cord blood, which is matched with patients in need of transplants. As of March 31, 2020, Global Cord Blood managed three cord blood banks in the Beijing municipality, one in Guangdong province, and another in Zhejiang province. The company, which was previously known as China Cord Blood Corporation, changed its name in March 2018 and is headquartered in Central, Hong Kong. It is a subsidiary of Nanjing Ying Peng Hui Kang Medical Industry Investment Partnership.
NeoVista Inc is dedicated to the development of medical technologies that help to advance the treatment of wet age-related macular degeneration (AMD). Wet AMD affects more than 5 million people around the world and is a major cause of blindness in men and women over the age of 50. The unique technology being developed by NeoVista continues to show promise in clinical studies. It is our goal to help improve the quality of care and reduce the burden of this destructive condition on patients, physicians, and the healthcare system.
Prism Pharmaceuticals, Inc., an acute care pharmaceutical company, engages in developing and commercializing cardiovascular injectable products in the United States. Its products include NEXTERONE, an anti arrhythmic agent in the form of injectable amiodarone; and PM103, an intravenous formulation of clopidogrel bisulfate. The company was founded in 2004 and is based in King of Prussia, Pennsylvania.
Chroma Therapeutics Ltd. develops novel small molecule drugs based on chromatin biology and novel cell accumulation approaches for targeted cancer and inflammation treatments. Its products include Tosedostat, an oral aminopeptidase inhibitor; CHR-3996, an optimized histone deacetylase inhibitor for the treatment of cancer; and CHR-2845, a targeted solution for haemotological malignancies. The company was founded in 2000 and is based in Abingdon, United Kingdom.
Symphogen A/S is a late-stage biopharmaceutical company based in Ballerup, Denmark, with an operational presence in Somerville, New Jersey. The company specializes in developing innovative therapies for cancer and other significant diseases, focusing on recombinant polyclonal antibodies (rpAb). Its product pipeline includes Sym004, a mixture of two monoclonal antibodies targeting different epitopes of EGFR for metastatic colorectal cancer and glioblastoma; Sym013, which inhibits EGFR, HER2, and HER3; and Sym015, aimed at eliminating the MET receptor. Additionally, Sym021 is designed to block PD1, while Sym009 is a monoclonal antibody conjugated to an antibiotic for treating resistant strains of staphylococcus aureus. Symphogen targets various epithelial cancer indications, including colorectal, lung, brain, breast, pancreatic, and head and neck cancers. Founded in 2000, Symphogen continues to advance its mission in the biopharmaceutical sector.
Light Sciences Oncology, Inc. develops and manufactures talaporfin sodium for the treatment of tumors and other indications in patients. The company also offers drug activator, an LED based single use disposable device that provides a fixed light dose. Its drug is used for the treatment of patients with hepatocellular carcinoma, metastatic colorectal cancer, and benign prostatic hyperplasia and enlargement of the prostate. The company was founded in 1994 and is based in Bellevue, Washington.
Light Sciences Oncology, Inc. develops and manufactures talaporfin sodium for the treatment of tumors and other indications in patients. The company also offers drug activator, an LED based single use disposable device that provides a fixed light dose. Its drug is used for the treatment of patients with hepatocellular carcinoma, metastatic colorectal cancer, and benign prostatic hyperplasia and enlargement of the prostate. The company was founded in 1994 and is based in Bellevue, Washington.
Receptor Biologix develops receptor-based biological therapeutics for cancer, inflammatory, and autoimmune diseases. The company is headquartered in Palo Alto, California.
Confluent Surgical develops products to address the need for surgical sealing and post-surgical adhesion prevention applications.The company provides DuraSeal, an adjunct to sutured dural repair during cranial surgeries to provide watertight closure. The company was founded in 1998 and is headquartered in Waltham, Massachusetts.
Bausch Health Companies Inc. is a global specialty pharmaceutical, consumer health, and medical device company headquartered in Laval, Canada. The company develops, manufactures, and markets a diverse range of products primarily in the therapeutic areas of eye health, gastroenterology, and dermatology. Bausch Health operates through four main segments: Bausch + Lomb/International, Salix, Ortho Dermatologics, and Diversified Products. The Bausch + Lomb segment focuses on vision care, surgical, and consumer ophthalmology products, while Salix specializes in gastroenterology. Ortho Dermatologics offers dermatological products, and the Diversified Products segment includes pharmaceuticals in neurology and other therapeutic areas. Bausch Health is recognized as a leader in consumer vision care in markets such as India and China and ranks among the top vision care companies in the United States. The company was previously known as Valeant Pharmaceuticals International, Inc. before rebranding in July 2018.
Dow Pharmaceutical Sciences
Venture Round in 2005
Dow Pharmaceutical Sciences, Inc. engages in the development of topical drug products for pharmaceutical and biotechnology clients.
Symphogen A/S is a late-stage biopharmaceutical company based in Ballerup, Denmark, with an operational presence in Somerville, New Jersey. The company specializes in developing innovative therapies for cancer and other significant diseases, focusing on recombinant polyclonal antibodies (rpAb). Its product pipeline includes Sym004, a mixture of two monoclonal antibodies targeting different epitopes of EGFR for metastatic colorectal cancer and glioblastoma; Sym013, which inhibits EGFR, HER2, and HER3; and Sym015, aimed at eliminating the MET receptor. Additionally, Sym021 is designed to block PD1, while Sym009 is a monoclonal antibody conjugated to an antibiotic for treating resistant strains of staphylococcus aureus. Symphogen targets various epithelial cancer indications, including colorectal, lung, brain, breast, pancreatic, and head and neck cancers. Founded in 2000, Symphogen continues to advance its mission in the biopharmaceutical sector.
LipoSonix, Inc. operates as a medical device company. The company develops non-invasive body sculpting products for aesthetic applications. The company was founded in 1999 and is based in Bothell, Washington. As of July 1, 2008, LipoSonix, Inc. operates as a subsidiary of Medicis Pharmaceutical Corp.
Accumetrics is a privately-held company based in San Diego, California, specializing in the development, manufacturing, and marketing of the VerifyNow System. This system comprises a comprehensive suite of assays designed for the assessment of platelet function, which is crucial in various medical applications, particularly in cardiovascular care. Founded in 1996, Accumetrics was initially sold to Radiometer in 2000 but was repurchased by its management and investors in 2003. The company continues to focus on providing essential tools for healthcare professionals to improve patient outcomes through effective monitoring of platelet activity.
Xanodyne Pharmaceuticals, Inc. operates as an integrated specialty pharmaceutical company that offers developing and commercializing products in women’s healthcare and pain management in the United States.The company was formerly known as Xanodyne Pharmacal, Inc. and changed the name to Xanodyne Pharmaceuticals, Inc. in February, 2004. Xanodyne Pharmaceuticals, Inc. was incorporated in 2000 and is based in Newport, Kentucky.
Revance Therapeutics, Inc. is a biotechnology company focused on the development, manufacture, and commercialization of neuromodulators for aesthetic and therapeutic uses. The company’s lead product, DaxibotulinumtoxinA for injection (DAXI), is undergoing clinical trials for various conditions, including glabellar lines, cervical dystonia, adult upper limb spasticity, and chronic migraine. In addition, DAXI is being evaluated for cosmetic applications such as forehead lines and lateral canthal lines. Revance is also developing DaxibotulinumtoxinA Topical for both therapeutic and aesthetic purposes, and it is working on a biosimilar to BOTOX in collaboration with Mylan. Founded in 1999 and originally known as Essentia Biosystems, the company is headquartered in Newark, California.
InSound Medical, Inc., a privately held, venture-backed company based in Newark, California, develops and manufactures next-generation hearing solutions. Major investors include Johnson & Johnson, DeNovo Ventures, CMEA Ventures, and Psilos Group Managers, LLC.
BioForm Medical, Inc., a medical aesthetics company, focuses on developing and commercializing products that are used by physicians to enhance a patient's appearance. Its core product is RADIESSE, an injectable dermal filler used to provide aesthetic improvement for patients. It markets its products through sales representatives and third party distributors to dermatologists, plastic surgeons, facial plastic surgeons, and other physicians performing cosmetic procedures in the United States, Europe, and internationally.
Rinat, which means "happiness" in Hebrew, was formed in 2001 when Genentech, a leader in the development of therapeutic antibodies, narrowed its focus and spun out its key neuroscience assets under a broad license to Rinat. Genentech invested significant R&D resources in support of these assets over 15 years, and Rinat is now building on them as the pioneer in developing and commercializing antibody drugs for the treatment of diseases and disorders of the nervous system.
InSound Medical, Inc., a privately held, venture-backed company based in Newark, California, develops and manufactures next-generation hearing solutions. Major investors include Johnson & Johnson, DeNovo Ventures, CMEA Ventures, and Psilos Group Managers, LLC.
Iomai Corporation discovers and develops vaccines and immune system stimulants, delivered via a novel, needle-free technology called transcutaneous immunization (TCI). TCI taps into the unique benefits of a major group of antigen-presenting cells found in the outer layers of the skin to generate an enhanced immune response. Iomai is leveraging TCI to enhance the efficacy of existing vaccines, enable new vaccines that are viable only through transcutaneous administration and expand the global vaccine market. The company was incorporated in 1997 and is based in Gaithersburg, Maryland. Intercell USA, Inc. was formerly known as Iomai Corporation. As a result of the acquisition of Iomai Corporation by Intercell Ag, Iomai Corporation's name was changed. As of August 5, 2008, Intercell USA, Inc. operates as a subsidiary of Intercell Biomedical Research & Development AG.
LifeCell Corporation develops and markets tissue repair products for use in reconstructive, urogynecologic, and orthopedic surgical procedures. The company’s products include Strattice Reconstructive Tissue Matrix and AlloDerm Regenerative Tissue Matrix for plastic, reconstructive, general surgical, burn, and periodontal procedures; Cymetra Regenerative Tissue Matrix, a particulate form of AlloDerm Tissue Matrix suitable for injection; and Repliform Regenerative Tissue Matrix for urogynecologic surgical procedures. It also offers GraftJacket for orthopedic surgical procedures; AlloCraft DBM for bone grafting procedures; and REVOLVE System that offers fat transfer processing in a range of aesthetic and reconstructive procedures. The company was founded in 1986 and is based in Branchburg, New Jersey. As of February 1, 2017, LifeCell Corporation operates as a subsidiary of Allergan plc.
According to American Heart Association statistics, 20,000-40,000 patients in the United States would benefit from a heart transplant. The MicroMed DeBakey VAD®, jointly developed with Dr. Michael DeBakey, Dr. George Noon and the National Aeronautics and Space Administration (NASA), has the potential to keep many of these people alive until a donor heart becomes available. Weighing less than four ounces, the device is silent and is approximately 1/10 the size of other pulsatile products on the market. The MicroMed DeBakey VAD® is designed to be a lower-cost, less invasive alternative to the commercially available, larger ventricular assist devices (VADs).
Confluent Surgical develops products to address the need for surgical sealing and post-surgical adhesion prevention applications.The company provides DuraSeal, an adjunct to sutured dural repair during cranial surgeries to provide watertight closure. The company was founded in 1998 and is headquartered in Waltham, Massachusetts.
Inhibitex
Venture Round in 2002
Inhibitex is a clinical-stage biopharmaceutical company dedicated to the development of innovative products that can treat or prevent serious infections. They are applying our expertise in the development of a portfolio of high-value, differentiated infectious disease therapies, each of which has the potential to significantly improve existing standards of care. Their pipeline addresses major viral and bacterial infections, including herpes zoster (shingles), HCV, and S. aureus infections.
Symphogen A/S is a late-stage biopharmaceutical company based in Ballerup, Denmark, with an operational presence in Somerville, New Jersey. The company specializes in developing innovative therapies for cancer and other significant diseases, focusing on recombinant polyclonal antibodies (rpAb). Its product pipeline includes Sym004, a mixture of two monoclonal antibodies targeting different epitopes of EGFR for metastatic colorectal cancer and glioblastoma; Sym013, which inhibits EGFR, HER2, and HER3; and Sym015, aimed at eliminating the MET receptor. Additionally, Sym021 is designed to block PD1, while Sym009 is a monoclonal antibody conjugated to an antibiotic for treating resistant strains of staphylococcus aureus. Symphogen targets various epithelial cancer indications, including colorectal, lung, brain, breast, pancreatic, and head and neck cancers. Founded in 2000, Symphogen continues to advance its mission in the biopharmaceutical sector.
Spinal Concepts
Series E in 2001
Spinal Concepts is a biotechnology company focused on spinal fixation products used in the treatment of spinal disorders, diseases, and injuries. The company was founded by Erin McGurk in 1996.
InSound Medical, Inc., a privately held, venture-backed company based in Newark, California, develops and manufactures next-generation hearing solutions. Major investors include Johnson & Johnson, DeNovo Ventures, CMEA Ventures, and Psilos Group Managers, LLC.
Since the company’s founding, Cord Blood Registry® (CBR®) has led the industry in technical innovations and provided families with access to current treatments and experimental stem cell therapies for conditions that have no cure. Cord Blood Registry (CBR) is the world’s largest newborn stem cell company. Founded in 1992, CBR is entrusted by parents with storing samples from more than 500,000 children. CBR is dedicated to advancing the clinical application of cord blood and cord tissue stem cells by partnering with institutions to establish FDA-regulated clinical trials for conditions that have no cure today. CBR has helped more than 300 families use their cord blood stem cells for established and experimental medical treatments, more than any other family cord blood bank. CBR’s goal is to expand the potential scope of newborn stem cell therapies that may be available to patients and their families. Cord Blood Registry is headquartered in San Bruno, California. CBR’s owned 80,000 square foot laboratory is located in Tucson, Arizona. Cord Blood Registry is a registered trademark of CBR Systems, Inc. CBR maintains standards for cellular therapy services through AABB accreditation, FDA-registration, and CLIA certification. CBR has the longest history of accreditation with the AABB (formerly known as the American Association of Blood Banks) and the company’s quality standards have been recognized through ISO 9001:2008 certification — the global business standard for quality. A pioneer in newborn stem cell collection and cryopreservation, CBR believes in the power of newborn stem cells to improve lives today and their potential to revolutionize treatment for many conditions in the future. CBR is the first family newborn stem cell bank to partner with leading research institutions to establish FDA-regulated clinical trials exploring the potential regenerative ability of stem cells to help treat conditions that have no cure today, including: acquired hearing loss, autism, cerebral palsy, and pediatric stroke. In fact, 73% of the stem cell units released by CBR have been used for experimental regenerative therapies – more than any other family cord blood bank in the world.
Rinat, which means "happiness" in Hebrew, was formed in 2001 when Genentech, a leader in the development of therapeutic antibodies, narrowed its focus and spun out its key neuroscience assets under a broad license to Rinat. Genentech invested significant R&D resources in support of these assets over 15 years, and Rinat is now building on them as the pioneer in developing and commercializing antibody drugs for the treatment of diseases and disorders of the nervous system.
iKnowMed, a privately held healthcare company located in Berkeley, California, is building the world's leading clinical infomediary, a trusted repository and resource for mission-critical, real-time, point-of-care information. Using patented web-based programs iKnowMed uniquely captures, analyzes, and displays patient treatment information at the point-of-care, enabling clinicians to advance the standard of care during medicine's moments of truth. In addition, iKnowMed's electronic infomediary provides unprecedented opportunities for physicians, patients, and pharmaceutical organizations to interact with and benefit from one another.
Healthgrades, headquartered in Denver, Colorado, is the leading online resource for comprehensive information about physicians and hospitals. Today, more than one million people a day use the Healthgrades website to search, compare and connect with hospitals and physicians based on the most important factors when selecting a healthcare provider: experience, hospital quality and patient satisfaction. For more information about Healthgrades, visit http://www.healthgrades.com or download the Healthgrades iPhone app.
WholePeople.com Inc. is a diverse e-commerce platform focused on the "Whole Living" sector. It offers a comprehensive range of information and products related to health and wellness, including natural vitamins, supplements, herbs, and body care items. The website features sections dedicated to health and body, food, natural home, travel, and wellness plans approved by physicians. This allows users to access relevant information while also providing the option to purchase various goods online, catering to a global audience interested in holistic health solutions.
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