Amkey Ventures

Amkey Ventures, LLC is a venture capital firm founded in 2001 and located in Fremont, California. The firm specializes in investments in cutting-edge biomedical technologies, focusing on areas such as medical devices, drug development, antibody production, GPCR reagents, and stem cell research. Amkey Ventures manages two funds and aims to identify promising investment opportunities within the biomedical sector. The firm typically prefers to acquire minority stakes in its portfolio companies, reflecting its strategic approach to fostering innovation in the healthcare industry.

George J. Lee

Managing Director and Founder

12 past transactions

Cardiva Medical

Venture Round in 2014
Cardiva Medical, Inc. is a medical device company based in Santa Clara, California, specializing in innovative vascular access management products that facilitate the healing process following percutaneous catheterization procedures. Founded in 2002, the company develops and markets several key products, including the VASCADE VCS, an extravascular and bioabsorbable femoral access closure system that promotes rapid hemostasis while reducing complications for patients. Additionally, Cardiva offers the Cardiva CATALYST, a manual compression assistance device that enhances coagulation and provides temporary hemostasis. The company also manufactures the VASCADE MVP, designed for multi-site venous closure in electrophysiology procedures. Cardiva Medical primarily serves physicians and cardiac centers across the United States, focusing on transforming vascular closure to benefit patients and healthcare providers.

Apexigen

Series A in 2013
Apexigen Inc. is a clinical-stage biopharmaceutical company based in San Carlos, California, focused on developing antibody therapeutics for cancer treatment. Established in 2010, Apexigen specializes in immuno-oncology, creating therapies that aim to leverage the patient's immune system to effectively combat and eradicate cancer. The company's pipeline includes several promising candidates, such as APX005M and APX201 for immuno-oncology, along with additional programs targeting various oncology and inflammation conditions. Notably, its lead candidate, sotigalimab, is currently in clinical development, complemented by a range of preclinical immuno-oncology programs. Apexigen also utilizes its proprietary APXiMAB platform to discover novel antibodies targeting immune system pathways, underscoring its commitment to advancing innovative treatments in cancer care.

Cardiva Medical

Venture Round in 2012
Cardiva Medical, Inc. is a medical device company based in Santa Clara, California, specializing in innovative vascular access management products that facilitate the healing process following percutaneous catheterization procedures. Founded in 2002, the company develops and markets several key products, including the VASCADE VCS, an extravascular and bioabsorbable femoral access closure system that promotes rapid hemostasis while reducing complications for patients. Additionally, Cardiva offers the Cardiva CATALYST, a manual compression assistance device that enhances coagulation and provides temporary hemostasis. The company also manufactures the VASCADE MVP, designed for multi-site venous closure in electrophysiology procedures. Cardiva Medical primarily serves physicians and cardiac centers across the United States, focusing on transforming vascular closure to benefit patients and healthcare providers.

Cardiva Medical

Venture Round in 2011
Cardiva Medical, Inc. is a medical device company based in Santa Clara, California, specializing in innovative vascular access management products that facilitate the healing process following percutaneous catheterization procedures. Founded in 2002, the company develops and markets several key products, including the VASCADE VCS, an extravascular and bioabsorbable femoral access closure system that promotes rapid hemostasis while reducing complications for patients. Additionally, Cardiva offers the Cardiva CATALYST, a manual compression assistance device that enhances coagulation and provides temporary hemostasis. The company also manufactures the VASCADE MVP, designed for multi-site venous closure in electrophysiology procedures. Cardiva Medical primarily serves physicians and cardiac centers across the United States, focusing on transforming vascular closure to benefit patients and healthcare providers.

Cardiva Medical

Series D in 2008
Cardiva Medical, Inc. is a medical device company based in Santa Clara, California, specializing in innovative vascular access management products that facilitate the healing process following percutaneous catheterization procedures. Founded in 2002, the company develops and markets several key products, including the VASCADE VCS, an extravascular and bioabsorbable femoral access closure system that promotes rapid hemostasis while reducing complications for patients. Additionally, Cardiva offers the Cardiva CATALYST, a manual compression assistance device that enhances coagulation and provides temporary hemostasis. The company also manufactures the VASCADE MVP, designed for multi-site venous closure in electrophysiology procedures. Cardiva Medical primarily serves physicians and cardiac centers across the United States, focusing on transforming vascular closure to benefit patients and healthcare providers.

Multispan

Series B in 2007
Multispan, Inc. is a biotechnology company specializing in the development of assay tools for G-protein coupled receptors (GPCRs), which are crucial for drug discovery research. Founded in 2004 and based in Hayward, California, Multispan offers a comprehensive range of products and services, including the industry's largest collection of human GPCR clones and high-expression cell lines. The company provides GPCR cell line reagents for drug screening, compound profiling, and monoclonal antibody generation. Additionally, Multispan develops therapeutic antibody leads targeting inflammatory diseases and cancer. Their offerings also include custom compound profiling, cell line generation, and frozen cell and membrane preparation, along with scientific consultations that cover assay design and implementation, thereby supporting researchers in various stages of drug discovery.

Cardiva Medical

Series C in 2006
Cardiva Medical, Inc. is a medical device company based in Santa Clara, California, specializing in innovative vascular access management products that facilitate the healing process following percutaneous catheterization procedures. Founded in 2002, the company develops and markets several key products, including the VASCADE VCS, an extravascular and bioabsorbable femoral access closure system that promotes rapid hemostasis while reducing complications for patients. Additionally, Cardiva offers the Cardiva CATALYST, a manual compression assistance device that enhances coagulation and provides temporary hemostasis. The company also manufactures the VASCADE MVP, designed for multi-site venous closure in electrophysiology procedures. Cardiva Medical primarily serves physicians and cardiac centers across the United States, focusing on transforming vascular closure to benefit patients and healthcare providers.

VM Discovery

Series B in 2006
VM Discovery, Inc. is a drug design and discovery company based in Fremont, California, established in 2001. The company specializes in drug design and optimization services that enable clients to identify multi-property optimized drug candidates. VM Discovery employs advanced technology for comprehensive parallel multi-property and activity modeling, optimization, and virtual screening, which facilitates the selection of new and improved small molecule drug candidates with balanced potency. This innovative approach allows pharmaceutical and biotechnology companies to efficiently develop medicines while minimizing resource expenditure. Additionally, VM Discovery collaborates with various pharmaceutical and biotech firms in the United States and Asia to provide internally optimized drug candidates, enhancing its contributions to the drug development process.

Multispan

Series A in 2004
Multispan, Inc. is a biotechnology company specializing in the development of assay tools for G-protein coupled receptors (GPCRs), which are crucial for drug discovery research. Founded in 2004 and based in Hayward, California, Multispan offers a comprehensive range of products and services, including the industry's largest collection of human GPCR clones and high-expression cell lines. The company provides GPCR cell line reagents for drug screening, compound profiling, and monoclonal antibody generation. Additionally, Multispan develops therapeutic antibody leads targeting inflammatory diseases and cancer. Their offerings also include custom compound profiling, cell line generation, and frozen cell and membrane preparation, along with scientific consultations that cover assay design and implementation, thereby supporting researchers in various stages of drug discovery.

VM Discovery

Series A in 2004
VM Discovery, Inc. is a drug design and discovery company based in Fremont, California, established in 2001. The company specializes in drug design and optimization services that enable clients to identify multi-property optimized drug candidates. VM Discovery employs advanced technology for comprehensive parallel multi-property and activity modeling, optimization, and virtual screening, which facilitates the selection of new and improved small molecule drug candidates with balanced potency. This innovative approach allows pharmaceutical and biotechnology companies to efficiently develop medicines while minimizing resource expenditure. Additionally, VM Discovery collaborates with various pharmaceutical and biotech firms in the United States and Asia to provide internally optimized drug candidates, enhancing its contributions to the drug development process.

VM Discovery

Series A in 2003
VM Discovery, Inc. is a drug design and discovery company based in Fremont, California, established in 2001. The company specializes in drug design and optimization services that enable clients to identify multi-property optimized drug candidates. VM Discovery employs advanced technology for comprehensive parallel multi-property and activity modeling, optimization, and virtual screening, which facilitates the selection of new and improved small molecule drug candidates with balanced potency. This innovative approach allows pharmaceutical and biotechnology companies to efficiently develop medicines while minimizing resource expenditure. Additionally, VM Discovery collaborates with various pharmaceutical and biotech firms in the United States and Asia to provide internally optimized drug candidates, enhancing its contributions to the drug development process.

Renal Solutions

Series A in 2002
Renal Solutions is a company based in Warrendale, Pennsylvania, that specializes in the development of dialysis products and services. Founded in 2000, the company focuses on creating integrated medical devices for sorbent hemodialysis treatment, which is designed to improve care for patients suffering from chronic and acute kidney failure. By offering a clinical care model, Renal Solutions enables healthcare practitioners to provide convenient and flexible treatment options that utilize sorbent-based dialysis technology. In November 2007, Renal Solutions was acquired by Fresenius Medical Care, enhancing its capacity to deliver innovative renal care solutions.
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