HBM Healthcare Investments

ConnectRN, Inc. operates an online platform for hospitals and healthcare institutions to communicate with available nurses. The company’s platform provides various tools to connect healthcare providers to qualified and available staff via an alert system that is sent to their mobile devices. Its nurse management Web dashboard streamlines communication between nurses and nurse managers to ensure open shifts are filled. ConnectRN, Inc. was incorporated in 2014 and is based in Newton, Massachusetts.

Advanced Accelerator Applications (AAA), is a European Pharmaceutical Group founded in 2002 by Italian academics as a spin-off of the “European Organization for Nuclear Research” (CERN), Geneva, Switzerland), to develop innovative diagnostic and therapeutic products. AAA’s main focus is in the field of Molecular Imaging and targeted, individualized therapy for the management of patients with serious conditions (Personalized Medicine). AAA is a European leader in the production and commercialization of PET (Positron Emission Tomography) radiopharmaceuticals. PET is a state-of-the-art diagnostic technique that is today mainly used in clinical oncology, cardiology and neurology. AAA also produces a broad range of SPECT products. AAA currently has 17 production and R&D facilities able to manufacture both diagnostics and therapeutic MNM products, and has over 300 employees in 11 countries (France, Italy, UK, Germany, Switzerland, Spain, Poland, Portugal, Israel, United States and Canada).

Farmalisto is an online retailer that sells a range of products and services to its clients. The platform’s range of products include haircare, dampeners, solar protection, healing, moisturizing, anti-aging, toothbrushes, toothpastes, mouth rinses, dental silks, dentures, protection, cereals, baby hygiene, baby milks, and diapers. Farmalisto was launched in 2013 by Jose Mora Hernandez, Stefan Krautwald, and Matthias Fehr and is based in Bogota and Mexico City. Websites: https://www.farmalisto.com.mx https://www.farmalisto.com.co

Nereus Pharmaceuticals, Inc. engages in the discovery and development of therapeutics for the treatment of oncology, infectious diseases, and inflammation. The company uses its marine microbiology technologies for the discovery and development of drug candidates. Its oncology drug candidates include NPI-2358, a tumor vascular disrupting agent for the treatment of solid tumors; and NPI-0052, a proteasome inhibitor for the treatment of solid tumors, lymphomas, and multiple myeloma. The company was founded in 1998 and is based in San Diego, California.

Acusphere, Inc. operates as a specialty pharmaceutical company that develops and commercializes cardiovascular drugs. It offers Imagify (perflubutane polymer microspheres), a cardiovascular drug that evaluates myocardial perfusion and detects coronary artery disease. It provides Imagify as an injectable suspension. The company was formerly known as Polymers For Medicine, Inc. and changed its name to Acusphere, Inc. in March 2004. Acusphere, Inc. was founded in 1993 and is based in Watertown, Massachusetts.

Karius is a life sciences company focused on generating genomic insights for infectious diseases with a non-invasive Karius Test that helps clinicians make rapid, treatment decisions. By mapping each patient’s microbial landscape from a single blood draw, Karius moves closer to a vision of a world where infectious disease is no longer a major threat to human health. The Karius laboratory is CLIA-certified and CAP-accredited to perform high-complexity clinical laboratory testing.

mtm laboratories AG is an ISO 9001 and 13485 certified developer and manufacturer of In-Vitro Diagnostics for the early detection and diagnosis of cervical and other cancers. With headquarters in Heidelberg, Germany, and subsidiaries in the United States, France, Italy and Spain, mtm markets its proprietary CINtec(R) Histology Kit and CINtec(R) Cytology Kit as adjunct tools for the early detection and diagnosis of cervical cancer. These kits are based on mtm's proprietary E6H4(TM) antibody clone which was specifically developed for immunochemistry applications in both formalin-fixed paraffin-embedded tissue sections and alcohol fixed cervical cytology preparations. The target for mtm's cervical cancer early detection technology platforms is the evaluation of the over-expression of the cyclin-dependent kinase inhibitor p16INK4a. This sensitive and selective antibody clone is combined with GMP manufactured kit components to ensure reproducible quality and results.

Accuris Pharma is a pharmaceutical company that aims to develop innovative and superior medical methods and deliver them to patients.

ValCare, Inc., a medical device company, designs and develops devices and accessories for minimally invasive treatment of heart valve disease. The company was founded in 2012 and is based in Irvine, California.

Seer is a developer of a life sciences and health data platform intended to facilitate early, pre-symptomatic detection of chronic life-threatening diseases. The company's platform captures and translates molecular insights from the proteome with improved accuracy and speed, enabling healthcare professionals to detect cancer and neurological diseases, drive earlier treatment and improve patient outcomes.

Sublimity Therapeutics (formerly Sigmoid Pharma), is a specialty pharma company with offices in Dublin, Ireland, and Solana Beach, California. Sublimity’s goal is to identify and create meaningful new therapies for unmet clinical needs in gastrointestinal and immunological diseases. Sublimity’s priority focus is on its lead product, STI-0529, for treatment of moderate to severe ulcerative colitis.

Renovis, Inc. is a biopharmaceutical company developing drugs to treat neurological diseases and disorders. The Company is currently developing products for acute ischemic stroke, for the treatment of neuropathic pain, and for the treatment of acute post-operative pain.

1mg is a digital consumer healthcare platform that makes healthcare accessible, understandable, and affordable. It allows users to find information about medicines prescribed by doctors and also buy it. Users can find drugs by ailments, class, companies, and brands. Its doctor platform aims to transform how to find the right healthcare professional for a consumers' needs. Its diagnostics service brings transparency and price-effectiveness to lab tests. The company empowers Indian consumers and caregivers to select the most appropriate healthcare service at the best possible price. 1mg was launched on 2015 and its operations are headquartered in Gurugram, India.

Adrenomed AG, a biopharmaceutical company, engages in the development of monoclonal antibody therapies for the treatment of sepsis. The company develops Adrecizumab, a humanized monoclonal antibody drug candidate against Adrenomedullin, a vasoactive peptide hormone released by vascular endothelial cells. Adrenomed AG was founded in 2009 and is based in Hennigsdorf, Germany.

ALX Oncology is a preclinical stage biotechnology company developing innovative immuno-oncology therapies for cancer. It is an independent, private biotechnology company. The founding of Alexo Therapeutics was based upon technology invented by Aaron Ring, K. Christopher Garcia, Kipp Weiskopf, Aron Levin, and Irving Weissman at Stanford University. This discovery involves soluble versions of signal regulatory protein-α (SIRPα) that have been engineered to bind CD47 with significantly greater affinity than natural SIRPα.1.

1mg is a digital consumer healthcare platform that makes healthcare accessible, understandable, and affordable. It allows users to find information about medicines prescribed by doctors and also buy it. Users can find drugs by ailments, class, companies, and brands. Its doctor platform aims to transform how to find the right healthcare professional for a consumers' needs. Its diagnostics service brings transparency and price-effectiveness to lab tests. The company empowers Indian consumers and caregivers to select the most appropriate healthcare service at the best possible price. 1mg was launched on 2015 and its operations are headquartered in Gurugram, India.

Agensys a biotechnology company, engages in the research and development of therapeutic human monoclonal antibodies and antibody drug conjugates for the treatment of cancer. It offers products to treat various tumors, as well as prostate, pancreatic, and bladder cancers. The company, formerly known as UroGenesys, was founded in 1997 and is based in Santa Monica, California. As of December 18, 2007, Agensys, Inc. operates as a subsidiary of Astellas Pharma US, Inc.

Surface Logix is a drug development company which uses its expertise in biophysical chemistry to create new small molecule drugs with significantly improved pharmacokinetic (PK) and pharmacodynamic (PD) properties compared with class leaders.

Novellusdx develops tumor specific driver mutations. It focuses on testing targeted therapy drugs on emulated tumors and quantifying their therapeutic effect, monitoring the oncogenic activity of the patient's relevant genes and proteins, and monitoring the oncogenic activity before and after drug administration. Novellusdx develops assays that detect disregulated translocation of mutated signaling proteins to the nucleus; and measures the impact of a drug or drug candidate on a specific tumor, specifically in terms of its ability to inhibit the up-regulated signaling protein translocation to the nucleus. Haim Gil-ad and Yoram Altschuler founded it on May 1, 2011, with its headquarters in Jerusalem in Israel.

Surface Logix is a drug development company which uses its expertise in biophysical chemistry to create new small molecule drugs with significantly improved pharmacokinetic (PK) and pharmacodynamic (PD) properties compared with class leaders.

Vivacta Limited, a Sittingbourne, UK-based medical diagnostics company that develops an innovative platform for point of care testing. Vivacta’s innovative piezofilm technology platform enables the advancement of new near‐patient diagnostic products. The company has successfully developed a test for thyroid stimulating hormone (TSH), and is working on a multiple analyte cardiovascular diagnostic test for use in the emergency room and acute care settings, where there is a need for rapid diagnosis of possible heart attack and related time‐critical medical conditions.

AnaptysBio is a privately-held therapeutic antibody product company that uses of somatic hypermutation, or SHM, for antibody discovery and optimization. SHM is the body's natural process for generating potent antibodies to fight disease. The Company's SHM-Platform utilizes the key components of SHM and other techniques to generate antibodies for therapeutic applications through an iterative process of natural evolution and high-throughput selection a process that has been referred to as naturalizing antibodies. This versatile platform can be used both to discover and optimize antibodies directed at specific disease targets and also affinity mature existing antibodies to improve their binding properties. In addition to providing a more powerful approach to antibody discovery and protein optimization, it addresses a growing void in the therapeutic antibody field due to a string of acquisitions and licensing deals that have reduced the availability of many technologies.

NUANCE BIOTECH INC operates as a pharmaceutical development company. The company provides capsules, injections, and tubes. It also engages in research and development for drug development, commercial and academic platform for pharmaceuticals, and contract sales organization services. The company was founded in 2014 and is based in Shanghai, China.

Adrenomed AG, a biopharmaceutical company, engages in the development of monoclonal antibody therapies for the treatment of sepsis. The company develops Adrecizumab, a humanized monoclonal antibody drug candidate against Adrenomedullin, a vasoactive peptide hormone released by vascular endothelial cells. Adrenomed AG was founded in 2009 and is based in Hennigsdorf, Germany.

mtm laboratories AG is an ISO 9001 and 13485 certified developer and manufacturer of In-Vitro Diagnostics for the early detection and diagnosis of cervical and other cancers. With headquarters in Heidelberg, Germany, and subsidiaries in the United States, France, Italy and Spain, mtm markets its proprietary CINtec(R) Histology Kit and CINtec(R) Cytology Kit as adjunct tools for the early detection and diagnosis of cervical cancer. These kits are based on mtm's proprietary E6H4(TM) antibody clone which was specifically developed for immunochemistry applications in both formalin-fixed paraffin-embedded tissue sections and alcohol fixed cervical cytology preparations. The target for mtm's cervical cancer early detection technology platforms is the evaluation of the over-expression of the cyclin-dependent kinase inhibitor p16INK4a. This sensitive and selective antibody clone is combined with GMP manufactured kit components to ensure reproducible quality and results.

Turning Point Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in designing and developing novel small molecule targeted oncology therapies. It develops a pipeline of tyrosine kinase inhibitors (TKIs) that targets genetic drivers of cancer in TKI-naïve and TKI-pretreated patients. The company’s lead drug candidate repotrectinib is being evaluated in an ongoing Phase I/II trial called TRIDENT-1 for the treatment of patients with ROS1+ advanced non-small-cell lung cancer (NSCLC) and patients with ROS1+, NTRK+, or ALK+ advanced solid tumors. Its pipeline also includes multi-targeted drug candidates TPX-0046, a RET/SRC inhibitor; TPX-0022, a MET/CSF1R/SRC inhibitor; and TPX-0131, a preclinical ALK inhibitor. The company was founded in 2013 and is headquartered in San Diego, California.

mtm laboratories AG is an ISO 9001 and 13485 certified developer and manufacturer of In-Vitro Diagnostics for the early detection and diagnosis of cervical and other cancers. With headquarters in Heidelberg, Germany, and subsidiaries in the United States, France, Italy and Spain, mtm markets its proprietary CINtec(R) Histology Kit and CINtec(R) Cytology Kit as adjunct tools for the early detection and diagnosis of cervical cancer. These kits are based on mtm's proprietary E6H4(TM) antibody clone which was specifically developed for immunochemistry applications in both formalin-fixed paraffin-embedded tissue sections and alcohol fixed cervical cytology preparations. The target for mtm's cervical cancer early detection technology platforms is the evaluation of the over-expression of the cyclin-dependent kinase inhibitor p16INK4a. This sensitive and selective antibody clone is combined with GMP manufactured kit components to ensure reproducible quality and results.

Pacira Pharmaceuticals Inc. operates as a pharmaceutical company which engages in the development and manufacturing of injectable pharmaceutical products. Pacira Pharmaceuticals Inc. was formerly known as DepoTech Corp. was formerly as SkyePharma Inc. and changed its name to Pacira Pharmaceuticals Inc. in June, 2007. The company was founded in 1989 and is based in San Diego, California. Pacira Pharmaceuticals Inc. operates as a subsidiary of Pacira, Inc.

Interventional Spine, Inc. engages in the design, development, production, and distribution of implantable devices for the spine to patients, surgeons, and hospitals worldwide. It offers Opticage expandable interbody fusion device; and PERPOS PLS System compressible facet fixation system. The company provides devices for podiatric and orthopedic trauma markets; and sells its products through a network of distributors. The company was formerly known as Triage Medical, Inc. and changed its name to Interventional Spine, Inc. in November 2006. Interventional Spine, Inc. was founded in 2000 and is based in Irvine, California. As of January 3, 2017, Interventional Spine, Inc. operates as a subsidiary of DePuy Synthes, Inc.

Vascular Dynamics, Inc. develops and commercializes a catheter-delivered implant for the treatment of drug-resistant hypertension. It offers MobiusHD, an hypertension treatment amplifying the natural baroreceptor response in the carotid sinus with a minimally invasive procedure to stimulate vasodilation, reduce heart rate, modulate kidney response, and decrease blood pressure. The company was founded in 2008 and is based in Irvine, California.

ConnectRN, Inc. operates an online platform for hospitals and healthcare institutions to communicate with available nurses. The company’s platform provides various tools to connect healthcare providers to qualified and available staff via an alert system that is sent to their mobile devices. Its nurse management Web dashboard streamlines communication between nurses and nurse managers to ensure open shifts are filled. ConnectRN, Inc. was incorporated in 2014 and is based in Newton, Massachusetts.

Complexa, Inc. is a biopharmaceutical company that engages in the development of medicines to treat severe and life-threatening diseases involving fibrosis and inflammation. It develops a compound, CXA-10, which is an oral nitrated fatty acid compound being advanced for the treatment of focal segmental glomerulosclerosis (FSGS) and pulmonary arterial hypertension (PAH). The company was founded in 2008 and is based in Berwyn, Pennsylvania.

Sublimity Therapeutics (formerly Sigmoid Pharma), is a specialty pharma company with offices in Dublin, Ireland, and Solana Beach, California. Sublimity’s goal is to identify and create meaningful new therapies for unmet clinical needs in gastrointestinal and immunological diseases. Sublimity’s priority focus is on its lead product, STI-0529, for treatment of moderate to severe ulcerative colitis.

Delenex Therapeutics AG is a Swiss biotech company developing therapeutic antibody fragments targeting serious medical diseases with high unmet need. The company's fragments are being designed for local/topical application by using the benefits of an antibody therapy with only limited systemic exposure. Its clinically validated technology delivers antibodies exhibiting the highest affinity, solubility and stability all combined with a very low risk of immunogenicity.

Antiva Biosciences is a biopharmaceutical company developing novel, localized therapeutics for the treatment of diseases caused by HPV infection. The company was founded as Hera Therapeutics in 2012 by Dr. Karl Hostetler at The University of California San Diego. They are now Antiva Biosciences which is headquartered in South San Francisco.

SAI is an ideal drug discovery, development and manufacturing partner. Their pharma and biotech clients gain clear competitive advantages through shorter time to market and risk minimization using their integrated and high-quality scientific services. SAI’s mission is to help their partners develop innovative medicines quicker and at lower cost by providing reliable research and manufacturing solutions. Their guiding principles are to be reliable, communicate effectively, safeguard IP, invest in people and to adopt technologies. At SAI Life Sciences, developing a business relationship with their clients that benefits both parties is only the beginning. They have learned through experience, it is when they build a partnership with a customer, that they can truly amplify their mutual interests and successes. At SAI they will call this “+1” and it hints at the additional value they aim to find mutually in longer term relationships.

Sphingotec GmbH develops biomarkers for diagnosis, prediction, and monitoring of acute medical conditions, such as acute heart failure, acute kidney injury, and circulatory shock. The company was founded in 2002 and is based in Brandenburg, Germany.

Neuron23, Inc. develops and manufactures medicines for genetic disorders through artificial intelligence technology and genetics. It offers medicines for neurological diseases and immunological disorders. The company was incorporated in 2018 and is based in South San Francisco, California with an additional office in Munich, Germany.

Turning Point Therapeutics, Inc. is a clinical-stage structure-based drug design company for the discovery and development of precision medicines for cancer and other diseases. We are focusing on the design of novel chemical identities for established oncogene drivers with secondary resistant mutations, newly identified disease-driven targets, and potential targets regulating tumor microenvironment and tumor immunity.

Vascular Dynamics, Inc. develops and commercializes a catheter-delivered implant for the treatment of drug-resistant hypertension. It offers MobiusHD, an hypertension treatment amplifying the natural baroreceptor response in the carotid sinus with a minimally invasive procedure to stimulate vasodilation, reduce heart rate, modulate kidney response, and decrease blood pressure. The company was founded in 2008 and is based in Irvine, California.

Ophthotech Corporation, a biopharmaceutical company, develops various therapeutics to treat diseases of the eye. It is developing Fovista, which has completed Phase IIb clinical trials for use in combination with anti-VEGF drugs for the treatment of wet age-related macular degeneration (wet AMD); and ARC1905, a potent and selective inhibitor of complement factor C5 that has completed Phase I/IIa clinical trials to treat wet AMD. The company was founded in 2007 and is headquartered in New York, New York.

YmAbs is a clinical stage biopharmaceutical company that discovers and develops innovative treatments for cancer patients through immunotherapies. YmAbs utilizes its platform technologies to create next-generation humanized, affinity matured bispecific antibodies. To further improve its bispecific antibodies, the company collaborates on the development of a novel human protein tag that dimerizes T-cell engaging bispecific antibodies, which enables higher tumor binding and results in a longer serum half-life and a significantly greater T-cell mediated killing of tumor cells. YmAbs' treatments claims to potentially reduce longer-term toxicities associated with current chemotherapeutics and provide the potential for curative therapy even for patients with widespread disease. YmAbs’ goal is to drive multiple product candidates in select solid tumor cancers to FDA approval.

Karius is a life sciences company focused on generating genomic insights for infectious diseases with a non-invasive Karius Test that helps clinicians make rapid, treatment decisions. By mapping each patient’s microbial landscape from a single blood draw, Karius moves closer to a vision of a world where infectious disease is no longer a major threat to human health. The Karius laboratory is CLIA-certified and CAP-accredited to perform high-complexity clinical laboratory testing.

Genalyte, Inc., a San Diego, CA-based life sciences company developing and commercializing innovative next-generation multiplexing technology. Founded in 2007 and led by CEO and founder Cary Gunn, Genalyte has developed a new approach to immunodetection using silicon chip manufacturing methods. Its Maverick platform uses a technology called silicon photonics to directly measure protein binding between antibodies and antigens or hybridization of nucleic acids.

Sphingotec GmbH develops biomarkers for diagnosis, prediction, and monitoring of acute medical conditions, such as acute heart failure, acute kidney injury, and circulatory shock. The company was founded in 2002 and is based in Brandenburg, Germany.

Mineralys Therapeutics, Inc., a private, clinical-stage biopharmaceutical company founded by Catalys Pacific committed to developing best-in-class, novel therapy for the treatment of hypertension. The Company is driven to bring a targeted approach to the management of hypertension via the development of MLS-101. MLS-101, licensed from Mitsubishi Tanabe Pharma Corporation, is a highly selective and potent aldosterone synthase inhibitor that is being investigated for the treatment of hypertension.

Galera Therapeutics, Inc., a clinical stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the transformation of radiotherapy in cancer. The company’s lead product candidate is avasopasem manganese (GC4419), a small molecule dismutase mimetic, which is in Phase III clinical trial for the treatment of radiation-induced severe oral mucositis in patients with head and neck cancer, as well as in Phase IIa clinical trial for the treatment of radiotherapy-induced esophagitis in patients with lung cancer. It is also involved in developing GC4711, which is in Phase I/II clinical trial for the treatment of pancreatic and lung cancers. The company was founded in 2012 and is headquartered in Malvern, Pennsylvania.

Fennec Pharmaceuticals Inc. (TSX: FRX, OTC: Interim ADHXD, Final FENCF (October 2, 2014), is a clinical-stage biotechnology company developing Sodium Thiosulfate (STS), a chemo-protectant against hearing loss associated with platinum-based chemotherapy. STS is being investigated in two pediatric Phase III studies to evaluate the reduction of ototoxicity and impact on survival. Originating in Saharan North Africa, the fennec fox is the smallest of the foxes and uniquely adapted to high temperatures and low water environments. It has distinctively large ears which dissipate heat and provide a very sensitive hearing. These qualities of adaptability and resourcefulness led us to adopt the fox with the big ears as our new name and logo. Children undergoing chemotherapy are going through an extraordinarily challenging time and the loss of hearing only compounds the difficulty. Fennec Pharma, named after that resourceful and determined fennec fox hopes that STS will allow these children to keep their hearing and prevent permanent disability. As the company refocuses on this mission, it seemed appropriate to adopt the fox with the big ears as our new name and logo.

Mineralys Therapeutics, Inc., a private, clinical-stage biopharmaceutical company founded by Catalys Pacific committed to developing best-in-class, novel therapy for the treatment of hypertension. The Company is driven to bring a targeted approach to the management of hypertension via the development of MLS-101. MLS-101, licensed from Mitsubishi Tanabe Pharma Corporation, is a highly selective and potent aldosterone synthase inhibitor that is being investigated for the treatment of hypertension.

Genizon Biosciences Inc. discovers genes and biomarkers in common diseases using genome wide association studies (GWAS), leveraging its proven and proprietary technology platform and access to patients from the Quebec Founder Population.

Mpex Pharmaceuticals is a biopharmaceutical company developing new therapies to combat the growing issue of antibiotic resistance, with a particular focus on gram-negative organisms. The Company's internal development pipeline focuses on combining proprietary formulations, PK/PD strategies and novel potentiating agents with proven antibiotics to overcome or directly inhibit the molecular mechanisms in bacteria responsible for antibiotic resistance.

Anesiva, Inc., a biopharmaceutical company, engages in the development and commercialization of novel therapeutic treatments for pain management worldwide. Its lead product candidate includes Adlea, which completed multiple Phase II and Phase III trials for post-surgical, musculoskeletal, and neuropathic pain. The company was formerly known as AlgoRx Pharmaceuticals, Inc., it changed its name to Anesiva, Inc. in 2006. Anesiva, Inc. was founded in 1999 and is headquartered in South San Francisco, California. On January 15, 2010, Anesiva, Inc. filed a voluntary petition for liquidation under Chapter 7 in the U.S. Bankruptcy Court for the Northern District of California. On June 10, 2014 filed for Chapter 7 bankruptcy.

Ignis Therapeutics is a life science company developing innovative therapies in the field of the central nervous system. With a strong commitment to self-discovery and a development strategy to advance the treatment paradigm, Ignis Therapeutics transforms the approach to treating CNS conditions. Ignis Therapeutics is dedicated to developing products that significantly improve the lives of patients while also providing additional therapeutic options for physicians.

Arrakis Therapeutics is a developer of a drug discovery platform intended to target RNA. The company's platform integrates leading-edge RNA bioinformatic and structural tools to produce a pipeline of rSMs to treat a range of disease including neurology, oncology and rare genetic diseases, enabling physicians to offer enhanced care.

Suzhou Connect Biopharmaceuticals, Ltd., a clinical-stage company, discovers and develops novel medicines for the treatment of autoimmune diseases and inflammation. Its products in pipeline includes CBP-307, an orally-active, second-generation S1P1 agonist for the treatment of a range of autoimmune diseases, including inflammatory bowel disease, graft-versus-host disease, psoriasis, and multiple sclerosis; CBP-174 for allergic rhinitis and atopic dermatitis; and CBP-201, a novel monoclonal antibody for the treatment of atopic dermatitis, asthma, and other types of allergic inflammation. The company is headquartered in Taicang, China with operations in Melbourne and San Diego.

Neurelis is a specialty pharmaceutical company, licenses, develops, and commercializes product candidates for epilepsy and the broader central nervous system (CNS) market. It provides a differentiated approach to target unmet medical needs. Their application of novel technologies is designed to enhance the therapeutic benefit and patient care. The company was incorporated in 2007 and is based in Encinitas, California.

Nereus Pharmaceuticals, Inc. engages in the discovery and development of therapeutics for the treatment of oncology, infectious diseases, and inflammation. The company uses its marine microbiology technologies for the discovery and development of drug candidates. Its oncology drug candidates include NPI-2358, a tumor vascular disrupting agent for the treatment of solid tumors; and NPI-0052, a proteasome inhibitor for the treatment of solid tumors, lymphomas, and multiple myeloma. The company was founded in 1998 and is based in San Diego, California.

Vivacta Limited, a Sittingbourne, UK-based medical diagnostics company that develops an innovative platform for point of care testing. Vivacta’s innovative piezofilm technology platform enables the advancement of new near‐patient diagnostic products. The company has successfully developed a test for thyroid stimulating hormone (TSH), and is working on a multiple analyte cardiovascular diagnostic test for use in the emergency room and acute care settings, where there is a need for rapid diagnosis of possible heart attack and related time‐critical medical conditions.

BaroFold is a privately held biopharmaceutical company focused on the development of commercially attractive protein therapeutics for immunology indications. The company's goal is to discover, develop and commercialize protein biologics, some of which incorporate its proprietary PreEMTâ„¢ high pressure folding technology along with other state-of-the-art technologies. This pipeline contains therapeutics with an Immunology focus, including Multiple Sclerosis, Rheumatoid Arthritis, and Asthma.

Broncus Technologies is a medical technology company focused on developing minimally-invasive medical devices for emphysema and other lung diseases. Broncus is investigating the Exhale emphysema product line to perform our patented treatment method called Airway Bypass. Airway Bypass could be the first minimally-invasive procedure for the treatment of homogeneous, or diffuse, emphysema, which constitutes the majority of the emphysema patient population. Broncus is currently enrolling patients worldwide in our pivotal EASE Trial investigating a treatment of severe homogeneous emphysema. Broncus is located in Mountain View, CA (San Francisco Bay area). Broncus International is located in Nyon, Switzerland.

Shape Memory Therapeutics, Inc., a medical device company, focuses on the commercialization of medical devices based on shape memory polymer materials for minimally invasive (endovascular) applications. The company was founded in 2009 and is based in College Station, Texas.

SK biopharmaceuticals aims to become a top tier specialty pharmaceutical company with global new drugs & innovative pipeline in CNS / metabolic disorders and to provide world class specialized pharmaceutical manufacturing services.

Kolltan Pharmaceuticals, Inc., is a private company founded in 2007 that is developing novel monoclonal antibody (mAb) drugs targeting receptor tyrosine kinases (RTKs). Kolltan's primary targets derive from seminal discoveries made in the laboratory of Dr. Joseph Schlessinger, Chairman of the Department of Pharmacology at the Yale School of Medicine, and in Kolltan’s laboratories. Dr. Schlessinger's laboratory has characterized a novel molecular mechanism underlying activation of RTKs providing, for the first time, a clear molecular explanation — at atomic resolution — for the oncogenic activity of mutations that have been identified in a variety of human cancers.

Homology Medicines, Inc., a genetic medicines company, focuses on transforming the lives of patients suffering from rare genetic diseases. Its proprietary platform is designed to utilize its human hematopoietic stem cell derived adeno-associated virus vectors (AAVHSCs) to deliver genetic medicines in vivo either through a gene therapy or nuclease-free gene editing across a range of genetic disorders. The company’s various set of AAVHSCs allows company to target, through a single injection, a range of disease-relevant tissues, including the liver, central nervous system, peripheral nervous system, bone marrow, muscle, and eye. Its lead product candidate is HMI-102, which is in Phase 1/2 pheNIX clinical trial, a gene therapy for the treatment of phenylketonuria (PKU) in adults. The company also develops HMI-103 for the treatment of PKU in pediatric patients; and HMI-202 to treat metachromatic leukodystrophy. Homology Medicines, Inc. was founded in 2015 and is based in Bedford, Massachusetts.

Nereus Pharmaceuticals, Inc. engages in the discovery and development of therapeutics for the treatment of oncology, infectious diseases, and inflammation. The company uses its marine microbiology technologies for the discovery and development of drug candidates. Its oncology drug candidates include NPI-2358, a tumor vascular disrupting agent for the treatment of solid tumors; and NPI-0052, a proteasome inhibitor for the treatment of solid tumors, lymphomas, and multiple myeloma. The company was founded in 1998 and is based in San Diego, California.

Aptinyx Inc. is a biopharmaceutical company discovering and developing innovative therapies for challenging disorders of the brain and nervous system. Aptinyx has a proven platform for discovering proprietary compounds that work through a novel mechanism: modulation of the NMDA receptor to enhance pathways involved with nerve cell communication. This mechanism has applicability across a number of CNS disorders. Our goal is to rapidly advance our most promising drug candidates into clinical development for indications with high unmet medical need.

Novellusdx develops tumor specific driver mutations. It focuses on testing targeted therapy drugs on emulated tumors and quantifying their therapeutic effect, monitoring the oncogenic activity of the patient's relevant genes and proteins, and monitoring the oncogenic activity before and after drug administration. Novellusdx develops assays that detect disregulated translocation of mutated signaling proteins to the nucleus; and measures the impact of a drug or drug candidate on a specific tumor, specifically in terms of its ability to inhibit the up-regulated signaling protein translocation to the nucleus. Haim Gil-ad and Yoram Altschuler founded it on May 1, 2011, with its headquarters in Jerusalem in Israel.

Swixx Biopharma fully represents biopharma companies in the CEE. It is designed to fully replace biopharma, OTC, and medical device multinationals’ subsidiaries or business units in those countries, or therapeutic areas of CEE, that the multinational chooses not to enter, or to exit. The company was founded in 2014 and is registered in Baar, Switzerland. It has 100%-owned affiliates in Albania, Bosnia & Herzegovina, Bulgaria, Croatia, Czech Republic, Estonia, Greece, Hungary, Kosovo, Latvia, Lithuania, North Macedonia, Montenegro, Poland, Romania, Russia, Serbia, Slovakia, and Slovenia.

Neuron23, Inc. develops and manufactures medicines for genetic disorders through artificial intelligence technology and genetics. It offers medicines for neurological diseases and immunological disorders. The company was incorporated in 2018 and is based in South San Francisco, California with an additional office in Munich, Germany.

Iconic Therapeutics, Inc. operates as a biopharmaceutical company that translates tissue factor biology in angiogenesis, inflammation, and metastasis to develop new therapeutics for retinal disease and cancer. Its products include ICON-1, a fusion protein designed to address the basis of vision loss in age-related macular degeneration. Iconic Therapeutics, Inc. was incorporated in 2002 and is based in South San Francisco, California.

Farmalisto is an online retailer that sells a range of products and services to its clients. The platform’s range of products include haircare, dampeners, solar protection, healing, moisturizing, anti-aging, toothbrushes, toothpastes, mouth rinses, dental silks, dentures, protection, cereals, baby hygiene, baby milks, and diapers. Farmalisto was launched in 2013 by Jose Mora Hernandez, Stefan Krautwald, and Matthias Fehr and is based in Bogota and Mexico City. Websites: https://www.farmalisto.com.mx https://www.farmalisto.com.co

Ophthotech Corporation, a biopharmaceutical company, develops various therapeutics to treat diseases of the eye. It is developing Fovista, which has completed Phase IIb clinical trials for use in combination with anti-VEGF drugs for the treatment of wet age-related macular degeneration (wet AMD); and ARC1905, a potent and selective inhibitor of complement factor C5 that has completed Phase I/IIa clinical trials to treat wet AMD. The company was founded in 2007 and is headquartered in New York, New York.

Cathay Industrial Biotech, Ltd produces and sells green materials from renewable sources as an alternative to chemically manufactured products worldwide. It provides long-chain dibasic acids, bio-based pentamethylene diamine, and bio-based green nylons. The company is based in Shanghai, China.

Viela Bio is a clinical-stage biotechnology company engaged in developing and commercializing transformative treatments for severe inflammation and autoimmune diseases. Its product inebilizumab, is a humanized monoclonal antibody, designed to target CD19, a molecule expressed on the surface of a broad range of immune system B cells.

Amphora Medical is a Minnesota-based developer of medical devices and instruments. The company is currently working on a novel cystoscopic device that has the potential to improve bladder function and quality of life for people with Overactive Bladder Syndrome (OAB). It was founded in 2011 and is headquartered in Minneapolis, Minnesota, United States.

Swixx Biopharma fully represents biopharma companies in the CEE. It is designed to fully replace biopharma, OTC, and medical device multinationals’ subsidiaries or business units in those countries, or therapeutic areas of CEE, that the multinational chooses not to enter, or to exit. The company was founded in 2014 and is registered in Baar, Switzerland. It has 100%-owned affiliates in Albania, Bosnia & Herzegovina, Bulgaria, Croatia, Czech Republic, Estonia, Greece, Hungary, Kosovo, Latvia, Lithuania, North Macedonia, Montenegro, Poland, Romania, Russia, Serbia, Slovakia, and Slovenia.

Neurelis is a specialty pharmaceutical company, licenses, develops, and commercializes product candidates for epilepsy and the broader central nervous system (CNS) market. It provides a differentiated approach to target unmet medical needs. Their application of novel technologies is designed to enhance the therapeutic benefit and patient care. The company was incorporated in 2007 and is based in Encinitas, California.

Odyssey Therapeutics is building a machine learning-based platform to develop novel therapeutics focusing on cancer and autoimmune diseases.

Werewolf Therapeutics operates as an oncology biotherapeutics company advancing a pipeline of transformative cancer treatments. Werewolf Therapeutics is developing medicines designed to be delivered systemically, but remain inactive in the body until they reach the tumor microenvironment, where they stimulate a powerful immune response and unleash an attack on cancer cells.

Locus Pharmaceuticals, Inc. engages in developing novel and small molecule therapeutic drugs to address major unmet medical needs. The company has a computational drug design technology, which is used to develop a pipeline of drug development candidates, including direct and allosteric kinase inhibitors for cancer and inflammation diseases. Locus Pharmaceuticals, Inc. was formerly known as Locus Discovery, Inc. and changed its name to Locus Pharmaceuticals, Inc. in January 2003. The company was incorporated in 1998 and is based in Blue Bell, Pennsylvania. Locus Pharmaceuticals, Inc. is a former subsidiary of Sarnoff Corporation.

Thommen Medical develops, produces and sells dental implants under the brand name SPI (Swiss Precision Implant) as well as biomaterial solutions for bone and tissue regeneration. Thommen Medical Implants are designed to be precise and easy to use, thanks to collaboration with leading scientific and dental clinicians.

Swixx Biopharma fully represents biopharma companies in the CEE. It is designed to fully replace biopharma, OTC, and medical device multinationals’ subsidiaries or business units in those countries, or therapeutic areas of CEE, that the multinational chooses not to enter, or to exit. The company was founded in 2014 and is registered in Baar, Switzerland. It has 100%-owned affiliates in Albania, Bosnia & Herzegovina, Bulgaria, Croatia, Czech Republic, Estonia, Greece, Hungary, Kosovo, Latvia, Lithuania, North Macedonia, Montenegro, Poland, Romania, Russia, Serbia, Slovakia, and Slovenia.

Odyssey Therapeutics is a biotechnology company pioneering the efficient development of next-generation immunomodulators and oncology medicines. Odyssey is making a transformational impact on the field of drug discovery and is accelerating the path to clinical development to drive the creation of more effective precision medicines.

C Ray Therapeutics develops healthcare advancements through nuclear medicine. It was founded in 2020.

Adrenomed AG, a biopharmaceutical company, engages in the development of monoclonal antibody therapies for the treatment of sepsis. The company develops Adrecizumab, a humanized monoclonal antibody drug candidate against Adrenomedullin, a vasoactive peptide hormone released by vascular endothelial cells. Adrenomed AG was founded in 2009 and is based in Hennigsdorf, Germany.

Autonomic Technologies, Inc. is a medical device company that focuses on the development and commercialization of therapies for the treatment of autonomic disorders, particularly severe headache. It develops ATI Neurostimulation System, a device that delivers low-level energy directly to the area of the SPG for the treatment of chronic cluster headache. The company was founded in 2007 and is based in Mountain View, California with additional offices in Germany and Switzerland.

ChemoCentryx focuses on discovery, development and commercialization of orally-administered small molecule therapeutics that target chemokine receptors and related chemo-attractant receptors. Their small molecule product candidates is designed to target a specific chemokine or chemo-attractant receptor, thereby blocking the inappropriate immune system cascade underlying a given disease.

Cylene Pharmaceuticals, Inc., a biotech pharmaceutical company, engages in the discovery, development, and commercialization of small molecule drugs that target nucleolus and kill cancer cells. It offers nucleolus targeting agents, which are small-molecule targeted cancer therapeutic agents for carcinoid/neuroendocrine tumors and pediatric brain tumors; and serine/threonine protein kinase inhibitors. The company also provides pre-clinical stage oral drug candidates. Cylene Pharmaceuticals, Inc. was founded in 1997 as Cyternex, Inc. and changed its name to Cylene Pharmaceuticals, Inc. in October 2003. The company is based in San Diego, California.

YmAbs is a clinical stage biopharmaceutical company that discovers and develops innovative treatments for cancer patients through immunotherapies. YmAbs utilizes its platform technologies to create next-generation humanized, affinity matured bispecific antibodies. To further improve its bispecific antibodies, the company collaborates on the development of a novel human protein tag that dimerizes T-cell engaging bispecific antibodies, which enables higher tumor binding and results in a longer serum half-life and a significantly greater T-cell mediated killing of tumor cells. YmAbs' treatments claims to potentially reduce longer-term toxicities associated with current chemotherapeutics and provide the potential for curative therapy even for patients with widespread disease. YmAbs’ goal is to drive multiple product candidates in select solid tumor cancers to FDA approval.

1mg is a digital consumer healthcare platform that makes healthcare accessible, understandable, and affordable. It allows users to find information about medicines prescribed by doctors and also buy it. Users can find drugs by ailments, class, companies, and brands. Its doctor platform aims to transform how to find the right healthcare professional for a consumers' needs. Its diagnostics service brings transparency and price-effectiveness to lab tests. The company empowers Indian consumers and caregivers to select the most appropriate healthcare service at the best possible price. 1mg was launched on 2015 and its operations are headquartered in Gurugram, India.

Corvidia Therapeutics is a clinical stage company focused on the research, development, and commercialization of transformative therapies for cardio-renal diseases. The Company is currently developing potential treatments for chronic kidney disease with atherosclerotic cardiovascular disease and inflammation, and high triglyceride-induced acute pancreatitis.

BioAtla, Inc., a biopharmaceutical company, develops specific and selective antibody-based therapeutics for the treatment of various cancers. Its lead product candidate is BA3011, a conditionally active biologic (CAB) antibody-drug conjugate (ADC) for soft tissue and bone sarcoma tumors, non-small cell lung cancer (NSCLC), and other tumor types. It also develops BA3021, a CAB ADC for NSCLC and Melanoma; and BA3071, which is a CAB anti-cytotoxic T-lymphocyte-associated antigen 4 antibody for renal cell carcinoma, NSCLC, small cell lung cancer, hepatocellular carcinoma, melanoma, bladder cancer, gastric cancer, and cervical cancer. The company was founded in 2007 and is based in San Diego, California.

Kolltan Pharmaceuticals, Inc., is a private company founded in 2007 that is developing novel monoclonal antibody (mAb) drugs targeting receptor tyrosine kinases (RTKs). Kolltan's primary targets derive from seminal discoveries made in the laboratory of Dr. Joseph Schlessinger, Chairman of the Department of Pharmacology at the Yale School of Medicine, and in Kolltan’s laboratories. Dr. Schlessinger's laboratory has characterized a novel molecular mechanism underlying activation of RTKs providing, for the first time, a clear molecular explanation — at atomic resolution — for the oncogenic activity of mutations that have been identified in a variety of human cancers.

Vascular Dynamics, Inc. develops and commercializes a catheter-delivered implant for the treatment of drug-resistant hypertension. It offers MobiusHD, an hypertension treatment amplifying the natural baroreceptor response in the carotid sinus with a minimally invasive procedure to stimulate vasodilation, reduce heart rate, modulate kidney response, and decrease blood pressure. The company was founded in 2008 and is based in Irvine, California.

Vitaeris Inc. develops biopharmaceuticals based on anti-interleukin-6 (IL-6) monoclonal antibody clazakizumab for treatment of chronic inflammatory diseases. The company was founded in 2016 and is based in Vancouver, Canada. As of June 11, 2020, Vitaeris Inc. operates as a subsidiary of CSL Limited.

Polyneuron is a developer of novel therapeutics intended to facilitate the treatment of antibody-mediated autoimmune diseases. The company's biodegradable glycopolymers-based therapeutics selectively eliminate the pathological autoantibodies, while leaving the rest of the immune system intact, enabling medical practitioners to treat patients with immune disorders in a safe and effective manner.

Dren Bio is a biotechnology company with a portfolio of attractive projects focused on powerful protein engineering technologies for the depletion of cells, protein aggregates, and other disease-causing agents. It is a holding company business model aimed at creating value with multiple projects as stand-alone assets.