i2E

i2E is a private not-for-profit venture development organization based in Oklahoma City, Oklahoma, founded in 1997. It focuses on investing in technology-based entrepreneurs and companies, particularly those in the software, healthcare, and information technology sectors. As a key component of Oklahoma's Innovation Model, i2E receives support from the Oklahoma Center for the Advancement of Science and Technology. The organization also manages for-profit venture capital fund subsidiaries, which collectively hold over $47 million in assets. Through its investments, i2E aims to foster growth and innovation within the state's entrepreneurial ecosystem.

Scott Meacham

Co-Founder / President and CEO

Rex Smitherman

President

64 past transactions

Big Ass Bag

Pre Seed Round in 2023
Bab provides convenience in the online shopping experience through a universal shopping cart that allows users to add different items from different stores, all in one place, in a Big Ass Bag. Bab allows those making purchasing decisions to compare products, curate a collection, and save and share selections when shopping online.

PrivacyBrain

Seed Round in 2021
PrivacyBrain is a cybersecurity platform focused on protecting individuals' personal identification information from exposure on data broker sites. The platform automates the removal of exposed personal information, enabling organizations to safeguard their executives and employees from potential cyber threats, including phishing attacks. Users can access an intuitive dashboard that provides visibility into the exposed personal information and the status of its removal. Following the initial removal, PrivacyBrain continues to monitor data broker sites for any newly exposed information, automatically initiating removal requests as necessary. By addressing the root causes of personal information exposure, PrivacyBrain helps clients maintain a secure environment for their employees while mitigating risks associated with publicly available personal identifying information.

THG Energy Solutions

Seed Round in 2019
THG Energy Solutions, LLC specializes in providing energy management solutions through a comprehensive web-based platform. The company offers a range of services, including energy analytics, sustainability reporting, automated demand response, and load management, aimed at helping clients optimize their energy usage and reduce costs. With capabilities in data collection, verification, and accounts payable integration, THG serves a diverse clientele, including governments, healthcare facilities, educational institutions, multi-location retailers, and various commercial entities. Founded in 2003 and headquartered in Austin, Texas, with additional offices in Tulsa and Atlanta, THG Energy Solutions leverages its team's expertise in energy marketing, building controls, engineering, and data management to deliver tailored solutions that prioritize clients' interests. The company has formed a strategic alliance with Energy Hippo, Inc. to enhance its service offerings.

Simergent

Seed Round in 2019
Simergent, LLC is a company that manufactures automated peritoneal dialysis devices aimed at providing affordable home dialysis solutions for both developed and emerging markets. Founded in 2014, the company is headquartered in Oklahoma City, Oklahoma, with additional operations in Chicago, Illinois. Simergent's devices are designed to be cost-effective and user-friendly, featuring a disposable tubing set that operates independently to troubleshoot issues. This innovation allows patients to maintain a normal lifestyle and socialize with family and friends while undergoing treatment at home.

BPEndo

Venture Round in 2019
BPEndo, LLC is a medical device company based in Norman, Oklahoma, founded in 2016. The company specializes in developing an insufflation retention device designed to address the problem of a deflating colon during colonoscopies. This innovative device creates an airtight seal in the rectum, which helps prevent air or fluid incontinence. By maintaining proper insufflation, the device allows physicians to maneuver the endoscope with greater freedom, ultimately enhancing the safety and efficiency of colonoscopic procedures.

Progentec Diagnostics

Venture Round in 2018
Progentec Diagnostics, Inc. is focused on developing advanced diagnostic tests aimed at improving the management of systemic lupus erythematosus (SLE). The company's flagship platform, aiSLE DX, offers tools such as a flare prediction score, which proactively measures disease activity, and an early diagnosis test for lupus. Established in 2015 and headquartered in Oklahoma City, Oklahoma, Progentec collaborates with various research institutions and experts globally to leverage innovations in diagnostics. The company is dedicated to addressing significant unmet needs in healthcare by enhancing disease management through improved diagnostic capabilities, ultimately aiming to facilitate early detection and reduce disease incidence.

Whiteboard Mortgage CRM

Series A in 2018
Whiteboard CRM is a specialized customer relationship management software designed for mortgage professionals, developed by experienced industry producers. Recognized for its innovation, the platform helps loan officers and branch managers enhance their business by fostering relationships with clients and referral partners. The software streamlines lead management, partner interactions, and team productivity, allowing lenders to implement effective business strategies across their organizations. It supports sales, marketing, and follow-up campaigns while ensuring compliance, enabling mortgage businesses to close more loans and boost referrals. By automating communication through pre-loaded content and phone scripts, Whiteboard CRM empowers users to maintain consistent engagement with clients and partners, ultimately driving revenue growth.

SendaRide

Series A in 2018
SendaRide, Inc. is a company based in Oklahoma City, Oklahoma, that specializes in providing non-emergency medical transportation services. Founded in 2016, SendaRide operates a platform tailored for the healthcare industry, enabling users to book both on-demand and pre-scheduled transportation. The application offers customized transport solutions for non-emergency medical patients, the elderly, and children, allowing users to find suitable transportation options easily. Additionally, the platform includes features such as GPS monitoring, live video feeds during transportation, and the ability to rate drivers or caretakers based on the services received. This comprehensive approach ensures that patients can reach their destinations safely and reliably.

Raw Space For Rent

Seed Round in 2018
Raw Space For Rent Inc. is an online marketplace established in 2015 and headquartered in Oklahoma City, Oklahoma. The company provides a platform that connects individuals seeking to rent out their unused spaces with those in need of temporary rental locations for various purposes. Users can list and discover a wide range of spaces suitable for events such as weddings, art performances, and pop-up shops, as well as practical uses like car storage and workspaces. This peer-to-peer renting platform enables a diverse array of activities, catering to creative and practical needs alike, thereby fostering a community-oriented approach to space utilization.

iRecommend Software™

Series A in 2017
iRecommend Software™ develops intelligent business solutions utilizing artificial intelligence (AI), machine learning, and dynamic data modeling. In a consumer-driven economy, businesses across all industries, are facing the challenge to remain relevant and provide highly personalized products and services. iRecommend's leading solution, Recommendation360™ is a recommendation engine with applications across multiple industries, including recruiting, real estate, retail/e-commerce, entertainment, travel, government, and healthcare. These industry-specific solutions enable businesses to generate hyper-personalized recommendations of products and services for their customers. Recommendation360's proprietary technology rapidly aggregates and analyzes millions of data points from the public domain to provide the right products or services to the right person at the right time. Headquartered in Tulsa, Oklahoma with offices in Oklahoma City, New York, San Francisco, London, and Dubai.

Clear River Enviro

Series A in 2017
Clear River Enviro, LLC is a manufacturer and marketer of devices designed to enable hospitals and nursing homes to safely and conveniently dispose of pharmaceutical waste. Founded in 2009, the company is headquartered in Sugar Land, Texas. Its focus on environmentally responsible waste management solutions addresses the growing need for safe disposal methods in the healthcare sector.

Linear Health Sciences

Series A in 2017
Linear Health Sciences is a medical device company focused on developing innovative products for medical tubing, utilizing its proprietary breakaway safety-valve technology. This technology aims to prevent unwanted disconnection of medical tubing, thereby enhancing the healthcare experience for patients, caregivers, and healthcare facilities. The company has made significant strides in securing global patent protections and obtaining FDA clearance for its flagship product, the Orchid Safety Release Valve. With a total addressable market exceeding $1 billion annually, Linear Health Sciences was founded by a physician and two engineers, emphasizing a strong blend of medical and engineering expertise in its product development efforts.

Progentec Diagnostics

Venture Round in 2017
Progentec Diagnostics, Inc. is focused on developing advanced diagnostic tests aimed at improving the management of systemic lupus erythematosus (SLE). The company's flagship platform, aiSLE DX, offers tools such as a flare prediction score, which proactively measures disease activity, and an early diagnosis test for lupus. Established in 2015 and headquartered in Oklahoma City, Oklahoma, Progentec collaborates with various research institutions and experts globally to leverage innovations in diagnostics. The company is dedicated to addressing significant unmet needs in healthcare by enhancing disease management through improved diagnostic capabilities, ultimately aiming to facilitate early detection and reduce disease incidence.

MaxQ

Seed Round in 2017
MaxQ LLC designs and manufactures cold chain packaging solutions tailored for the life sciences sector. Established in 2012 and headquartered in Stillwater, Oklahoma, the company specializes in insulated shipping containers that ensure the safe transportation of temperature-sensitive goods, including blood, biologics, and pharmaceuticals. MaxQ offers operationally validated thermal control packaging suitable for clinical trials and provides pre-qualified pack-outs that can maintain product integrity for up to three days, customized for specific ambient conditions. Their solutions aim to minimize the risk of product loss due to breakage and inadequate insulation, thereby supporting the healthcare industry in maintaining the quality and safety of critical materials during transit.

Happily

Seed Round in 2017
Happily is a developer of a date-planning application designed to help couples rediscover and enhance their date nights. The app offers personalized date ideas, gifting suggestions, and monthly subscription boxes tailored for couples, ensuring users can enjoy a unique experience each month. By facilitating activities that encourage quality time together, Happily aims to foster deeper connections and meaningful moments in relationships. Through its user-friendly platform, couples can conveniently access a variety of engaging options to enrich their time spent together.

Happily

Seed Round in 2017
Happily is a developer of a date-planning application designed to help couples rediscover and enhance their date nights. The app offers personalized date ideas, gifting suggestions, and monthly subscription boxes tailored for couples, ensuring users can enjoy a unique experience each month. By facilitating activities that encourage quality time together, Happily aims to foster deeper connections and meaningful moments in relationships. Through its user-friendly platform, couples can conveniently access a variety of engaging options to enrich their time spent together.

Spiers New Technologies

Venture Round in 2016
Spiers New Technologies Inc. specializes in repair, remanufacturing, refurbishing, and repurposing services for battery packs utilized in hybrid and electric vehicles. By providing these 4R services, the company assists original equipment manufacturers in effectively managing the life cycle of their battery inventory. Additionally, Spiers New Technologies conducts qualitative analyses and safety screenings of batteries removed from vehicles, along with logistics management that includes monitored, climate-controlled storage and end-of-life recycling preparation. The company also offers contract design and manufacturing services for energy storage systems applicable to various non-vehicle sectors, such as stationary electricity storage, vehicle recharging stations, solar support systems, and uninterruptible power supply systems. Incorporated in 2014 and headquartered in Oklahoma City, Oklahoma, Spiers New Technologies maintains additional offices in EDE, the Netherlands.

WeGoLook

Series A in 2015
WeGoLook, LLC is a mobile technology company that provides on-demand inspection and verification services through a crowdsourced network of over 30,000 independent contractors, known as "Lookers." The company operates both nationally and internationally, offering services such as auto, property, and equipment inspections, as well as custom tasks like document retrieval and delivery. Clients, including businesses and individual consumers, can request on-site inspections and receive detailed reports, which include dynamic data, photos, and videos. WeGoLook specializes in verifying a wide range of assets, including vehicles, real estate, and heavy equipment, and supports various industries, notably insurance and retail, by managing risk and facilitating claims processes. The company was founded in 2009 and is headquartered in Oklahoma City, Oklahoma, operating as a subsidiary of Crawford & Company.

Synereca Pharmaceuticals

Venture Round in 2015
Synereca Pharmaceuticals, Inc. is a research-stage biopharmaceutical company focused on developing orally active drugs that enhance the effectiveness of existing antibiotics. Founded in 2009 and headquartered in Chapel Hill, North Carolina, with additional laboratories in Oklahoma City, the company specializes in compounds that improve the activity of Colistin against gram-negative bacteria while minimizing toxicity. Its portfolio includes prototypic RecA inhibitors targeting various pathogenic bacteria, such as E. coli, which are responsible for critical infections, including those of the lungs, urinary tract, and skin. Synereca's platform identifies multiple chemical subclasses of compounds designed to potentiate current classes of antibiotics, including polymyxins, carbapenems, aminoglycosides, and fluoroquinolones, thereby providing drug manufacturers with effective solutions for bacterial infections.

Exaptive

Seed Round in 2015
Exaptive, Inc. is a company focused on providing an application development platform specifically for data science. Established in 2011 and based in Oklahoma City, Oklahoma, Exaptive facilitates innovation through its tools and community-oriented features. Its primary offerings include the Xap Store, an app store for data applications, and Cognitive Network, a platform that connects users with new techniques and collaborators based on their activities within the Exaptive environment. The company aims to enhance productivity by simplifying the organization of teams and promoting seamless collaboration on data analysis, enabling users to effectively connect with stakeholders and generate innovative solutions for complex problems.

Moleculera Biosciences

Venture Round in 2015
Moleculera Labs was founded by Drs. Craig Shimasaki and Madeleine Cunningham in 2011, to medically understand and clinically identify the underlying biological root of neurological, psychiatric, and behavioral disorders. Similar to the emergence of the immuno-oncology connection, epidemiological and research evidence demonstrates that a large portion of neuropsychiatric disorders are caused by an autoimmune dysfunction. The Company owns and operates a fully accredited clinical laboratory with its first revenue generating product—a blood panel called the Cunningham Panel™ that detects brain and nervous system targeted autoimmune antibodies in patients with neurologic, psychiatric, and behavioral disorders triggered by an infection. Patients are diagnosed with PANS, PANDAS, autism spectrum disorder, ADD/ADHD, bipolar disorder, anxiety disorder, Tourette’s, obsessive compulsive disorder (OCD), schizophrenia, or other neurologic and psychiatric syndromes, whereas the root may be a dysfunctional immune response. Symptoms include OCD, anxiety, depression, psychosis, motor or vocal tics, verbal and non-verbal communication difficulty, deteriorating social skills, eating disorders, academic regression, and rage. These patients are typically prescribed neuropsychiatric drugs, often resulting in little or no improvement. However, once a patient is correctly diagnosed through testing, treatment is redirected towards the immune system, neuroinflammation, and subclinical infections, resulting in remarkable recoveries, sometimes after decades of suffering. Moleculera is the sole clinical laboratory performing this panel covered by two U.S. patents. The Company has received and processed over 13,000 blood specimens ordered by over 1,700 physicians in over 50 countries, all prior to launching a sales force. The Company generated $1.1 MM in 2021 and is preparing to scale for revenue expansion with expectations of revenue ~$25 MM in 4-5 years. The company is now applying this technology to autoimmune cardiovascular disease and Long-COVID symptoms. The basic research that led to the identification of these antineuronal antibody targets was studied for over 20 years in the laboratory of Dr. Madeleine Cunningham at The University of Oklahoma Health Sciences Center, with subsequent collaboration from the Pediatric Branch of the National Institutes of Mental Health (NIMH). Scientific and clinical results have been published in multiple top-tier peer-reviewed journals. Certain infections that have been found to trigger these autoimmune antibodies include strep, Lyme, mycoplasma, Babesia, bartonella, coxsackie virus, and others. Medical journals have reported an autoimmune response to SARS-CoV-2 (COVID-19), with approximately one-third of patients experiencing some neurologic or psychiatric symptoms. The patented Cunningham Panel™ consists of five tests. Four which measure levels of autoantibodies directed against Dopamine D1 receptor, Dopamine D2L receptor, Lysoganglioside GM1, and Tubulin. A fifth test measures CaM Kinase II activation, a key enzyme involved in the production of neurotransmitters dopamine, epinephrine, and norepinephrine. Autoimmune antibodies that bind to these targets interfere with or block normal neurologic activity in the brain and nervous system. The laboratory results assist a physician in making a diagnosis and identifying the appropriate therapy. In addition to individual clinicians who order the panel, the Company has provided testing to over 80 medical institution customers. In a 2020 publication in the Journal of Neuroimmunology, the Cunningham Panel demonstrated an 88% sensitivity and 92% specificity with an accuracy of 90% correlating these autoantibody elevations and neuropsychiatric symptoms before and after treatment. The Cunningham Panel aids a clinician’s treatment decision by directing them to the underlying subclinical infections and neuroimmune dysfunction, rather than simply treating symptoms. Effective treatments typically include various anti-infectives, anti-inflammatory agents and immunomodulators. Moleculera' s Test Panel generates an average realized revenue of $900 through existing CPT codes and patient billing. The Company has generated over $10 million in cumulative revenue since opening. During the COVID-19 pandemic, revenues for 2021 were $1.1 million, all prior to adding a sales force. Approximately 10% of orders come from a growing international market, with the Company receiving orders from over 1,700 clinicians. Moleculera Labs has one of the largest IRB approved and clinically annotated serum specimen biobanks of over 13,000 specimens utilized for research and development of new products for autoimmune neuropsychiatric disorders. The Company has demonstrated its panel’s clinical utility in multiple neuropsychiatric disorders and have been able to predict treatment efficacy while working with pharmaceutical and research partners to assist in identifying novel drug targets. There is a clear unmet medical need and demand in this $23 billion dollar neuropsychiatric and behavioral disorder market. Moleculera recently in-licensed exclusive technology for multiple autoimmune antibody targets against the heart, which are implicated in a portion of multiple cardiovascular diseases such as heart failure, cardiomyopathy, atrial fibrillation, and myocarditis. With this technology along with proposed clinical studies and validation in process, the Company expects to develop and commercialize two additional panels. One panel will target various cardiovascular diseases (world-wide market of $4.9 trillion) infection-triggered autoimmunity, and another panel for diagnosing and treatment-monitoring of Long-COVID (estimated at $6.5 trillion). Our precision medicine business model is fashioned after Foundation Medicine and Genomic Health, whose precision medicine companies were acquired by Roche in 2018 for $5.3 billion, and Exact Sciences in 2019 for $2.8 billion, respectively. Moleculera Labs is led by Dr. Craig Shimasaki, a serial entrepreneur with over 35 years of biotechnology experience, who began his career at Genentech. He co-founded multiple companies, participated in taking several companies public into the U.S. and the Canadian stock exchange, led five products through the FDA diagnostic approval process, and has directed two CLIA labs, raising over $30 million for these companies. Dr. Madeleine Cunningham, Chief Scientific Officer, is an internationally recognized leader in infection-induced autoimmune neuropsychiatric disorders and is a tenured professor at the University of Oklahoma with over 40 years of research and over 130 authored publications in leading scientific and medical journals. Dr. James Appleman is VP of R&D and Clinical Development and has 30+ years’ experience in building successful diagnostic and therapeutic companies from inception through successful exits, including a $230M exit to Roche. Mr. Fred Hiller is CFO and brings 45+ years’ experience in corporate finance and accounting. He began his career at Touche Ross & Co. in 1962, serving as controller at Elgin National and Columbia Pictures, and CFO at Wilkinson Sword. He has been a financial consultant to numerous companies including two biotechnology companies and one that was publicly traded.

Associated Material Processing

Convertible Note in 2015
Associated Material Processing, LLC specializes in the manufacture of chemical removal polymeric adsorbents aimed at purifying water. Established in 2011 and located in Stillwater, Oklahoma, the company produces proprietary products such as ERAsE 35, a granular mesh designed for the treatment of drinking water, groundwater, wastewater, and industrial applications, and ERAsE 50, a free-flowing powder used in filtration. The firm addresses the growing global issue of arsenic contamination, particularly in sectors like semiconductor manufacturing and processed foods, by providing low-cost media that effectively removes arsenic and other hazardous substances from various waste streams.

Valve Systems International

Seed Round in 2015
Valve Systems International specializes in the development of advanced control valves designed to manage fluid flow between high-pressure sources and low-pressure discharge volumes. Their innovative internal mechanical actuation system enhances the accuracy of fluid modulation, particularly in challenging choked flow conditions. By addressing issues such as cavitation and vibration, the company’s technology not only improves operational precision but also reduces internal damage, thereby increasing reliability and lowering overall operating costs. This results in decreased maintenance and repair requirements, making their solutions particularly beneficial for various industrial applications.

WeGoLook

Series A in 2014
WeGoLook, LLC is a mobile technology company that provides on-demand inspection and verification services through a crowdsourced network of over 30,000 independent contractors, known as "Lookers." The company operates both nationally and internationally, offering services such as auto, property, and equipment inspections, as well as custom tasks like document retrieval and delivery. Clients, including businesses and individual consumers, can request on-site inspections and receive detailed reports, which include dynamic data, photos, and videos. WeGoLook specializes in verifying a wide range of assets, including vehicles, real estate, and heavy equipment, and supports various industries, notably insurance and retail, by managing risk and facilitating claims processes. The company was founded in 2009 and is headquartered in Oklahoma City, Oklahoma, operating as a subsidiary of Crawford & Company.

Synereca Pharmaceuticals

Debt Financing in 2014
Synereca Pharmaceuticals, Inc. is a research-stage biopharmaceutical company focused on developing orally active drugs that enhance the effectiveness of existing antibiotics. Founded in 2009 and headquartered in Chapel Hill, North Carolina, with additional laboratories in Oklahoma City, the company specializes in compounds that improve the activity of Colistin against gram-negative bacteria while minimizing toxicity. Its portfolio includes prototypic RecA inhibitors targeting various pathogenic bacteria, such as E. coli, which are responsible for critical infections, including those of the lungs, urinary tract, and skin. Synereca's platform identifies multiple chemical subclasses of compounds designed to potentiate current classes of antibiotics, including polymyxins, carbapenems, aminoglycosides, and fluoroquinolones, thereby providing drug manufacturers with effective solutions for bacterial infections.

Roll-2-Roll Technologies

Seed Round in 2014
Roll-2-Roll Technologies LLC, based in Stillwater, Oklahoma, is a start-up that specializes in the development of electro-mechanical devices for roll-to-roll manufacturing applications. Founded in 2013 as a spin-off from Oklahoma State University, the company focuses on commercializing a lateral guide system which utilizes advanced sensor technology and sophisticated algorithms. Their products include a variety of web guide systems, sensors, controllers, and actuators designed to enhance manufacturing efficiency. By minimizing downtime and waste, Roll-2-Roll Technologies aims to provide manufacturers with innovative solutions that streamline production processes and improve overall operational effectiveness.

Well Checked Systems International

Seed Round in 2014
Well Checked Systems International, LLC, operating as WellChecked, specializes in remote monitoring solutions for oil and gas well sites. Founded in 2012 and based in Tulsa, Oklahoma, the company provides a comprehensive platform that includes video monitoring, reporting, alerting, and data storage. Its services are designed to assist pumpers, owners, and operators by enabling them to monitor well site activity from a distance. Key features include motion sensing, gate activity monitoring, tank level change alerts, and cloud-based video surveillance for easy retrieval. The platform aims to enhance safety and security while minimizing the costs and personnel required for on-site monitoring, thereby helping to prevent equipment damage and loss.

Monscierge

Seed Round in 2014
Monscierge, LLC is an international software company that specializes in innovative hospitality solutions. Founded in 2009 and based in Oklahoma City, it offers a mobile software platform called Connect, designed to enhance communication between hotel staff and guests. Connect includes various modules: Connect CMS for curating local content, Connect Web for extending brand communication, Connect Mobile for enabling guests to manage their stay and make requests, Connect Staff for real-time interactions, and Connect Lobby, a touch-interactive platform for guest engagement. The platform is accessible through smartphones, tablets, large-screen kiosks, and other devices, allowing hotels to provide personalized experiences and improve operational efficiency. With installations worldwide, Monscierge is committed to enhancing guest experiences and fostering customer loyalty within the hospitality industry.

Otologic Pharmaceutics

Series A in 2014
Otologic Pharmaceutics, Inc. is a biopharmaceutical company focused on developing innovative treatments for hearing disorders. Established in 2009 and located in Oklahoma City, the company is dedicated to addressing acute hearing loss, particularly through its lead product, HPN1010, an oral medication designed to treat acute noise-induced hearing loss. Otologic aims to prevent the progression to permanent hearing impairment and has plans to extend the applications of HPN1010 to other forms of hearing loss, including those caused by chemotherapy drugs like Cisplatin. Additionally, the company's research encompasses a range of therapeutic approaches, including programs for cochlear implant-related hearing loss and conditions such as Meniere's disease and tinnitus. By advancing these novel pharmacological solutions, Otologic Pharmaceutics seeks to improve the quality of life for individuals suffering from hearing impairment.

Smart Panel

Seed Round in 2014
Smart Panel is focused on developing an innovative home energy management system designed to be mounted on the circuit breaker of residential and small commercial buildings. Unlike competing technologies that manage power at individual switches and plugs, Smart Panel offers a comprehensive solution by controlling energy distribution directly at the breaker, the central hub for electrical management. This approach allows homeowners to effectively monitor and manage their energy usage through a single, cost-effective device. Equipped with digital relays connected to each circuit, the intelligent electrical panel enables users to track real-time energy consumption and remotely turn off entire circuits using a smartphone, providing both convenience and enhanced energy efficiency.

Miira

Seed Round in 2014
Miira Artist Tools specializes in developing innovative art tools aimed at enhancing the artistic capabilities of professionals and beginners alike. The company offers modern solutions that facilitate the creation, learning, and teaching of fundamental artistic principles. By addressing common challenges such as the depiction of space, depth, distance, and linear perspective, Miira provides valuable resources for artists, art instructors, designers, and architects. Their tools are designed to make the artistic process more convenient and efficient, ultimately helping users to improve their skills and express their creativity more effectively.

ZarthCode

Seed Round in 2014
ZarthCode is a developer of virtual reality hardware focused on creating affordable consumer-level wireless virtual reality gloves. The company specializes in product design, prototyping, and manufacturing, aiming to meet the diverse needs of users seeking immersive virtual reality experiences. Their flagship product, the Mantis VR glove, represents a significant advancement in accessibility for consumers interested in virtual reality technology. By prioritizing affordability and usability, ZarthCode is positioned to enhance the engagement and interactivity of virtual reality applications for a broader audience.

EQUIP Advantage

Seed Round in 2014
EQUIP Advantage provides immediate access to the oil and gas industry’s equipment at the right time.

SIVI

Seed Round in 2014
SIVI's core product is LaunchLeader, the micro-crowdfunding platform for entrepreneurs to rally supporters and raise startup money for their prototypes (MVPs). The unique fundraising design is set up like a wedding registry wish list so donors can back specific startup tools, e.g. video, logo, social media ads. LaunchLeader is positioned as a pre-Kickstarter/Indiegogo or pre-accelerator crowdfunding platform when friends and family are your main supporters. LaunchLeader's parent company, SIVI, is a virtual incubator started by successful founders dedicated to democratizing entrepreneurship.

Tetherex Pharmaceuticals

Seed Round in 2014
Tetherex Pharmaceuticals Corporation is a clinical-stage biopharmaceutical company based in Oklahoma City, Oklahoma, with an additional office in Morrisville, North Carolina. Founded in 2014, the company specializes in the development of therapeutics aimed at treating severe diseases related to inflammation, thrombosis, and tumor metastasis. Tetherex focuses on creating innovative first-in-class drugs, including SelK2, a humanized monoclonal antibody that targets cell adhesion proteins involved in thrombotic, inflammatory, and oncologic conditions. By addressing the molecular mechanisms of these diseases, Tetherex aims to improve the quality of life for patients affected by these serious health issues.

4DSales

Seed Round in 2014
4DSales is a company based in Tulsa, Oklahoma, that specializes in a tablet-based mobile sales application designed for sales professionals. This application allows users to effectively showcase products using live action videos, photos, and PDFs of specifications, thereby enhancing customer engagement. It is designed to be fast and user-friendly, enabling sales teams to respond quickly to inquiries and present services with confidence. Through its tools and services, 4DSales aims to improve sales performance and increase business revenue for its clients.

Tailwind

Seed Round in 2013
Tailwind is a prominent marketing platform tailored for small businesses, entrepreneurs, creators, and marketers. It provides tools that facilitate the planning, creation, execution, and optimization of marketing campaigns across various digital platforms, including email, Facebook, Instagram, and Pinterest. By integrating multiple standalone marketing tools into a unified system, Tailwind aims to empower small businesses to become effective omni-channel marketers, catering to their specific needs. Additionally, Tailwind offers a utility-first CSS framework designed to simplify content marketing, enabling users to enhance their marketing efforts and connect with a broader audience. Through its comprehensive suite of services, Tailwind is reshaping the marketing landscape for small businesses.

Moleculera Biosciences

Seed Round in 2013
Moleculera Labs was founded by Drs. Craig Shimasaki and Madeleine Cunningham in 2011, to medically understand and clinically identify the underlying biological root of neurological, psychiatric, and behavioral disorders. Similar to the emergence of the immuno-oncology connection, epidemiological and research evidence demonstrates that a large portion of neuropsychiatric disorders are caused by an autoimmune dysfunction. The Company owns and operates a fully accredited clinical laboratory with its first revenue generating product—a blood panel called the Cunningham Panel™ that detects brain and nervous system targeted autoimmune antibodies in patients with neurologic, psychiatric, and behavioral disorders triggered by an infection. Patients are diagnosed with PANS, PANDAS, autism spectrum disorder, ADD/ADHD, bipolar disorder, anxiety disorder, Tourette’s, obsessive compulsive disorder (OCD), schizophrenia, or other neurologic and psychiatric syndromes, whereas the root may be a dysfunctional immune response. Symptoms include OCD, anxiety, depression, psychosis, motor or vocal tics, verbal and non-verbal communication difficulty, deteriorating social skills, eating disorders, academic regression, and rage. These patients are typically prescribed neuropsychiatric drugs, often resulting in little or no improvement. However, once a patient is correctly diagnosed through testing, treatment is redirected towards the immune system, neuroinflammation, and subclinical infections, resulting in remarkable recoveries, sometimes after decades of suffering. Moleculera is the sole clinical laboratory performing this panel covered by two U.S. patents. The Company has received and processed over 13,000 blood specimens ordered by over 1,700 physicians in over 50 countries, all prior to launching a sales force. The Company generated $1.1 MM in 2021 and is preparing to scale for revenue expansion with expectations of revenue ~$25 MM in 4-5 years. The company is now applying this technology to autoimmune cardiovascular disease and Long-COVID symptoms. The basic research that led to the identification of these antineuronal antibody targets was studied for over 20 years in the laboratory of Dr. Madeleine Cunningham at The University of Oklahoma Health Sciences Center, with subsequent collaboration from the Pediatric Branch of the National Institutes of Mental Health (NIMH). Scientific and clinical results have been published in multiple top-tier peer-reviewed journals. Certain infections that have been found to trigger these autoimmune antibodies include strep, Lyme, mycoplasma, Babesia, bartonella, coxsackie virus, and others. Medical journals have reported an autoimmune response to SARS-CoV-2 (COVID-19), with approximately one-third of patients experiencing some neurologic or psychiatric symptoms. The patented Cunningham Panel™ consists of five tests. Four which measure levels of autoantibodies directed against Dopamine D1 receptor, Dopamine D2L receptor, Lysoganglioside GM1, and Tubulin. A fifth test measures CaM Kinase II activation, a key enzyme involved in the production of neurotransmitters dopamine, epinephrine, and norepinephrine. Autoimmune antibodies that bind to these targets interfere with or block normal neurologic activity in the brain and nervous system. The laboratory results assist a physician in making a diagnosis and identifying the appropriate therapy. In addition to individual clinicians who order the panel, the Company has provided testing to over 80 medical institution customers. In a 2020 publication in the Journal of Neuroimmunology, the Cunningham Panel demonstrated an 88% sensitivity and 92% specificity with an accuracy of 90% correlating these autoantibody elevations and neuropsychiatric symptoms before and after treatment. The Cunningham Panel aids a clinician’s treatment decision by directing them to the underlying subclinical infections and neuroimmune dysfunction, rather than simply treating symptoms. Effective treatments typically include various anti-infectives, anti-inflammatory agents and immunomodulators. Moleculera' s Test Panel generates an average realized revenue of $900 through existing CPT codes and patient billing. The Company has generated over $10 million in cumulative revenue since opening. During the COVID-19 pandemic, revenues for 2021 were $1.1 million, all prior to adding a sales force. Approximately 10% of orders come from a growing international market, with the Company receiving orders from over 1,700 clinicians. Moleculera Labs has one of the largest IRB approved and clinically annotated serum specimen biobanks of over 13,000 specimens utilized for research and development of new products for autoimmune neuropsychiatric disorders. The Company has demonstrated its panel’s clinical utility in multiple neuropsychiatric disorders and have been able to predict treatment efficacy while working with pharmaceutical and research partners to assist in identifying novel drug targets. There is a clear unmet medical need and demand in this $23 billion dollar neuropsychiatric and behavioral disorder market. Moleculera recently in-licensed exclusive technology for multiple autoimmune antibody targets against the heart, which are implicated in a portion of multiple cardiovascular diseases such as heart failure, cardiomyopathy, atrial fibrillation, and myocarditis. With this technology along with proposed clinical studies and validation in process, the Company expects to develop and commercialize two additional panels. One panel will target various cardiovascular diseases (world-wide market of $4.9 trillion) infection-triggered autoimmunity, and another panel for diagnosing and treatment-monitoring of Long-COVID (estimated at $6.5 trillion). Our precision medicine business model is fashioned after Foundation Medicine and Genomic Health, whose precision medicine companies were acquired by Roche in 2018 for $5.3 billion, and Exact Sciences in 2019 for $2.8 billion, respectively. Moleculera Labs is led by Dr. Craig Shimasaki, a serial entrepreneur with over 35 years of biotechnology experience, who began his career at Genentech. He co-founded multiple companies, participated in taking several companies public into the U.S. and the Canadian stock exchange, led five products through the FDA diagnostic approval process, and has directed two CLIA labs, raising over $30 million for these companies. Dr. Madeleine Cunningham, Chief Scientific Officer, is an internationally recognized leader in infection-induced autoimmune neuropsychiatric disorders and is a tenured professor at the University of Oklahoma with over 40 years of research and over 130 authored publications in leading scientific and medical journals. Dr. James Appleman is VP of R&D and Clinical Development and has 30+ years’ experience in building successful diagnostic and therapeutic companies from inception through successful exits, including a $230M exit to Roche. Mr. Fred Hiller is CFO and brings 45+ years’ experience in corporate finance and accounting. He began his career at Touche Ross & Co. in 1962, serving as controller at Elgin National and Columbia Pictures, and CFO at Wilkinson Sword. He has been a financial consultant to numerous companies including two biotechnology companies and one that was publicly traded.

Codesy

Seed Round in 2013
Codesy operates an open-source marketplace designed to connect software developers with valuable software bugs. This platform allows coders to engage in a pay-what-you-want system, providing flexibility in how they set their fees and payments. By facilitating transactions between developers of open-source software and potential buyers, Codesy simplifies the process for programmers looking to offer their services. Users can easily connect with each other, fostering a collaborative environment for app and website development.

Offerboxx

Seed Round in 2013
Offerboxx is a location based marketing software that makes it possible for businesses to collect rich information from consumers on-site and in an engaging way. Offerboxx makes that data available instantly and in a way that measures the results of each campaign.

Synercon Technologies

Seed Round in 2013
Synercon Technologies, LLC is a technology company based in Tulsa, Oklahoma, specializing in extracting digital data from heavy vehicles involved in crashes. Founded in 2013, it develops innovative solutions to retrieve data from a vehicle's engine control module (ECM) in a forensically sound manner. Its key products include the Forensic Link Adapter (FLA), which downloads data from heavy vehicles, and the Smart Sensor Simulator, which allows investigators to conduct bench downloads without causing additional fault codes. Additionally, Synercon offers TruckCRYPT, a software solution that encrypts and presents extracted data to users. The company provides a range of services, including chip-level digital forensics, field data extraction, crash reconstruction, expert testimony, and electronics design. By employing a custom hardware and software approach, Synercon enhances the efficiency and reliability of forensic investigations in the heavy vehicle sector.

Tempered Mind

Seed Round in 2013
Tempered Mind specializes in creating engaging and mobile-friendly educational solutions. The company leverages modern mobile technology and popular gaming formats to deliver a unique e-learning experience. Its platform includes applications designed for educational purposes, notably the "Call to Knowledge: FLV" app, which assists users in building vocabulary for second language acquisition. By integrating effective teaching methods with innovative technology, Tempered Mind aims to make learning both enjoyable and accessible for users on the go.

Drik

Series A in 2013
Drik is a laboratory testing facility located in Oklahoma City that specializes in toxicology services for pharmaceutical companies developing new drugs. Founded and led by Kumar Sripathirathan, Drik offers customized testing solutions that assist researchers in determining toxicology requirements and evaluating the safety of their drug candidates. The company conducts a variety of pre-clinical screening tests, in vitro testing, and animal studies, alongside in vivo toxicology assessments and cell-based assays that investigate disease mechanisms. Through its comprehensive testing capabilities, Drik enables pharmaceutical companies to effectively identify and address safety concerns associated with new drug development.

Sway Medical

Series A in 2013
Sway Medical, LLC, founded in 2011 and based in Aledo, Texas, develops FDA-cleared mobile applications designed to monitor patient outcomes across various medical fields, including orthopedics, geriatrics, and pharmacology. The company's flagship product, Sway Balance, utilizes advanced motion analysis protocols and algorithms to assess balance and detect instability, particularly following head injuries. This mobile software enables healthcare professionals, sports coaches, and other users to conduct objective balance and reaction time testing in diverse environments, providing real-time data for concussion management and overall patient monitoring. By offering quantifiable insights into postural stability, Sway Medical aims to enhance the quality of care in physical therapy, orthopedic practices, senior living facilities, and worksite medical clinics.

ICEdot

Series A in 2013
ICEdot, a Tulsa, Oklahoma-based developer of a crash sensor attached to the safety helmet of sportsmen. Led by Chris Zenthoefer, CEO, ICEdot has developed a crash sensor attached to the safety helmet of cyclists, skiers, snow boarders, BMX bikers and other action sport participants to detect forces consistent with head injury and notify predesignated health and geolocation information over sms/text.

Retenant

Seed Round in 2013
Retenant specializes in providing a white label mobile platform tailored for apartment complexes, enabling property managers to enhance communication and engagement with residents. By offering a custom app, Retenant allows apartment managers to replace traditional methods of communication, such as paper fliers and emails, with a more efficient digital solution. The platform includes features like news feeds and direct messaging, facilitating immediate reporting of issues and suggestions from residents. This streamlined communication not only helps property managers address problems quickly but also fosters stronger relationships within the community, ultimately improving tenant satisfaction and service delivery.

The Campaign Solution

Seed Round in 2013
The Campaign Solution optimizes candidates’ time and resources. It was founded by Dan Mazzei in 2010.

EmpowrNet

Seed Round in 2013
EmpowrNet will offer a mobile application that supports consumers, their family members and their friends in their collective effort to manage the array of long term care services and supports required to safely live at home and avoid nursing home care. Nine of ten individuals age 50+ want to age in place - to live at home as independently as possible as long as possible and avoid nursing home placement. For both consumers and family members the primary concern related to supporting aging in place is retaining the control over their lives they had before the need for long term care services entered the picture. EmpolwrNet's communication tool will give consumers and their families the opportunity to retain control of their lives by gives them the tools to successfully manage the challenges of aging in place.

Medefy

Seed Round in 2013
Medefy is a healthcare app founded in 2018 and based in Tulsa, Oklahoma, that facilitates direct communication between employers and their employees regarding health benefits. The platform empowers health plan members by providing personalized guidance throughout their healthcare journey, helping them navigate the complexities of benefits offerings. Medefy enables employees to shop for better-priced, higher-quality healthcare providers in their area, while also offering tools such as telemedicine, narrow networks, and chronic disease management. By fostering engagement and informed decision-making, Medefy aims to improve healthcare outcomes and enhance the overall benefits experience for both employers and employees.

Polyskope Labs

Seed Round in 2013
PolySkope Labs specializes in clinical molecular diagnostics, focusing on innovative solutions for food safety testing. The company has developed the first comprehensive, modular, multiplex assay that allows for the simultaneous detection of one to three common foodborne pathogens. This groundbreaking technology significantly lowers the cost of analysis for food safety laboratories, achieving more than a threefold reduction. By utilizing a single overnight enrichment medium, PolySkope's product streamlines the detection process, reducing the need for extensive materials, labor, and equipment while also minimizing logistical challenges and regulatory burdens. This approach enables researchers to conduct food safety analyses more efficiently and cost-effectively.

Docvia

Seed Round in 2013
Docvia is a privately held software venture that provides secure, HIPAA-compliant electronic access between established patients and their health providers. The company's software was first commercially deployed at St. John Health System in Tulsa, Oklahoma. The Docvia team is comprised of practicing physicians, software engineers and designers that work together with community leaders in order to provide safe, simple and inexpensive health access around the world.

Expert TA

Venture Round in 2012
Expert TA, LLC offers a web-based grading software solution designed for professors and teaching assistants to efficiently grade homework assignments in subjects such as engineering, mathematics, physics, and chemistry. Founded in 2009 and based in Tulsa, Oklahoma, the company provides features like Homework Mode, which allows educators to create assignments and export grade information for integration with other software, and Tutorial Mode, which simulates the guidance a student might receive during tutoring sessions. This technology enables educators to focus more on teaching while the software handles the complex partial-credit grading of homework problems, enhancing both student learning and teaching effectiveness.

Perk Dynamics

Venture Round in 2012
Perk Dynamics, Inc. specializes in software solutions tailored for the hospitality and specialty coffee sectors. The company develops operational management tools designed to enhance the efficiency of coffee and espresso drink services. Notable products include AutoPerk, which streamlines the order entry process by connecting point-of-sale systems to coffee machines, and AutoPerk SelfCheck, a self-service solution for fresh bean-to-cup beverages. Additionally, PerkAlert offers remote access to essential information for managing gourmet coffee operations across multiple locations. Perk Dynamics serves a diverse clientele, including franchisors, roasters, maintenance providers, and restaurant operators in various settings such as grocery stores, hotels, and college campuses. Founded in 2009 and based in Shawnee, Oklahoma, the company aims to improve beverage quality and order flow efficiency, ultimately boosting profits and customer satisfaction.

DermaMedics

Venture Round in 2012
DermaMedics LLC is a pharmaceutical skin care company based in Oklahoma City, Oklahoma, specializing in the development of innovative topical therapeutics for dermatological conditions. Founded in 2010, the company focuses on creating products that treat issues such as psoriasis, acne, rosacea, and eczema. DermaMedics utilizes its expertise in skin research and product formulation to identify novel phytochemicals, including Therosol®, a botanically-derived compound known for its anti-inflammatory and anti-aging properties. Therosol® is effective in alleviating symptoms associated with various skin conditions without the adverse effects linked to traditional corticosteroids and immunosuppressive drugs. The company's product line includes anti-aging treatments, facial cleansers, hydrating lotions, and redness reduction emulsions, which are made available through retailers and targeted towards medical professionals.

Oklahoma Medical Research Foundation

Seed Round in 2012
OMRF is the Oklahoma Medical Research Foundation. We are dedicated to fighting Alzheimer’s, heart disease, lupus, MS, cancer and other devastating illnesses.

Alkami

Convertible Note in 2009
Alkami Technology, Inc. is a provider of cloud-based digital banking solutions tailored for credit unions and banks. The company offers the ORB Platform, a comprehensive Software-as-a-Service solution that facilitates retail and business banking features including account aggregation, person-to-person payments, payroll management, and analytics. Alkami's platform enhances user onboarding, engagement, and account servicing, allowing financial institutions to improve operational efficiency and drive revenue growth. Additionally, it includes integrated mobile banking solutions, a content management system for personalized marketing, and the flexibility to incorporate third-party solutions. Founded in 2007 and headquartered in Plano, Texas, Alkami was previously known as iThryv, LLC before rebranding in 2010.

Grocio

Seed Round in 2009
Grocio, Inc. is a grocery comparison shopping platform based in Tulsa, Oklahoma, that has been in operation since 2007. The company focuses on providing shoppers and grocers with local grocery prices through its comparison shopping services. Grocio offers several product lines, including real-time grocery pricing and coupon matching, which helps consumers save money by aligning discounts with their grocery lists. Additionally, Grocio develops mobile tools designed to enhance the shopping experience for both consumers and retailers.

Exerbotics

Seed Round in 2009
Exerbotics, LLC specializes in manufacturing advanced fitness and wellness equipment designed to enhance healthy living and improve quality of life. Established in 2004 and based in Tulsa, Oklahoma, the company provides a range of products for medical rehabilitation, senior living, and research applications. Their equipment includes machines for various muscle groups, such as chest press, shoulder press, squat, and leg extensions, which measure and record force output for analysis and training purposes. Exerbotics' technology not only tracks capability and monitors activity but also delivers detailed reports on biometrics and workout performance, ensuring that users can compare actual work against prescribed regimens.

Selexys Pharmaceuticals Corporation

Seed Round in 2009
Selexys Pharmaceuticals Corporation (Selexys) is a privately held company that is developing drugs to treat inflammatory and thrombotic diseases. They are targeting the underlying disease mechanism for these disorders. Their target is the adhesion of white blood cells to sites of inflammation mediated by the binding of two proteins, P-selectin and PSGL-1. The company is in preclinical development of humanized antibodies to P-selectin and PSGL-1 for the treatment of acute and chronic inflammatory and thrombotic disorders. Unregulated inflammatory processes play a major role in the harmful effects of multiple inflammatory disorders.

mobiManage

Angel Round in 2008
mobiManage specializes in developing mobile web solutions for businesses, focusing on creating engaging and adaptive technology that integrates seamlessly with existing websites, content management systems, and customer relationship management systems. The company aims to empower clients by providing them with unique mobile products and comprehensive marketing tools that enhance their mobile presence. With a portfolio of over 400 custom mobile websites and applications, mobiManage ensures compatibility across various platforms, including iOS, Android, Windows, and Blackberry. Their mobiPlatform allows clients to deploy and manage their mobile offerings easily, enabling real-time updates and modifications. Additionally, mobiManage offers a suite of marketing tools such as mobile advertising, surveys, and geolocation services, further supporting businesses in enhancing their digital brand identity and market reach. The company provides integrated responsive design solutions and interactive kiosk options, facilitating straightforward implementation of mobile strategies. Free estimates and proposals are also available to potential clients.

CreditPoint Software

Seed Round in 2008
CreditPoint Software, Inc. develops software solutions focused on commercial credit risk and collections management. Founded in 2000 and headquartered in Tulsa, Oklahoma, the company offers a SaaS platform that provides a range of features, including online credit applications, configurable scoring models, and analytics-driven monitoring. Its solutions help businesses, from small and medium enterprises to large corporations, streamline their credit and collections processes, manage counterparty risk, and improve cash forecasting. By integrating business intelligence reporting and rule-based workflows, CreditPoint Software aims to enhance efficiency and minimize errors for its clients, ultimately empowering them to address their credit management challenges effectively.

Lifetone Technology

Seed Round in 2008
Lifetone Technology, Inc. is a manufacturer and seller of bedside fire alarm and clock products, specifically designed to assist children, heavy sleepers, seniors, and individuals who are deaf or hard of hearing. The company's product line includes lifesaving alarming devices, such as bedside fire alarms and clocks, as well as a bed shaker that delivers strong and intermittent vibrations to alert users. Lifetone Technology markets its products online and through dealers across the United States. Founded in 2004 and based in Oklahoma City, Oklahoma, the company was previously known as InnovAlarm Corporation before rebranding in January 2008. Additionally, Lifetone Technology has expanded its presence with offices in Chicago.
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