i2E is a not-for-profit venture development organization based in Oklahoma City that supports technology-driven startups through investment and advisory services. Backed by state partners including the Oklahoma Center for the Advancement of Science and Technology as part of Oklahoma's Innovation Model, it was founded in 1997 and focuses on nurturing firms in software, healthcare, and information technology sectors in Oklahoma.

Cortado Ventures is a venture capital firm based in Oklahoma City, Oklahoma, founded in 2020. It backs capital-efficient, technology-driven B2B companies across insurtech, biotech, fintech, energy tech, aerospace, and agtech, with a focus on opportunities in Oklahoma.

Atento Capital is a Tulsa-based venture capital firm founded in 2020 that concentrates on seed- and early-stage technology investments. It seeks to generate returns while supporting quality job creation and helping Tulsa's tech ecosystem grow. The firm primarily invests in early-stage venture funds from across the country and globally, seeking partners with competitive advantages that can drive outsized returns and contribute to Tulsa's tech ecosystem. As a registered investment adviser, Atento Capital emphasizes disciplined, collaborative investment practices and a focus on technology-driven opportunities.

Echo Investment Capital is a strategic investor founded in 2010, focusing on innovative companies across various industries such as life sciences, technology, media, education, and real estate.

FortySix Venture Capital is a venture capital investment firm based in Tulsa, Oklahoma, founded in 2019. It focuses on investing in early-stage technology companies and supports their growth within active regional ecosystems.

Plains Ventures is a venture capital firm based in Oklahoma City, Oklahoma, founded in 2019. The firm focuses on early-stage investments, principally Seed and Series A financings, in groundbreaking ideas and entrepreneurs across the United States, including opportunities beyond traditional coastal hubs. With approximately two decades of industry experience, Plains Ventures seeks to support founders building ventures outside coastal enclaves by providing capital and guidance to accelerate growth.

HPS Investment Partners is a global investment firm focused on non-investment grade credit across the capital structure. Founded in 2007 and headquartered in New York, it operates a worldwide network of offices. The firm originated as a unit of Highbridge Capital Management, a subsidiary of J.P. Morgan Asset Management, and was acquired by its principals in 2016 after Highbridge’s hedge fund strategies remained with J.P. Morgan. HPS manages a variety of strategies, including syndicated leveraged loans, high-yield bonds, privately negotiated senior secured debt, mezzanine, asset-based lending, and private equity, and serves clients across industries such as insurance, healthcare, media, retail, logistics, and marine.

Mimosa Tree Capital Partners is a venture capital firm based in Tulsa, Oklahoma, that focuses on seed and early-stage technology investments.

Spur Capital Partners is a venture capital firm founded in 2001 and based in Oklahoma, United States. It focuses on early-stage, technology-centric investments across life sciences, artificial intelligence, bioinformatics, consumer, enterprise, and other technology sectors. The firm emphasizes building durable relationships with top-tier venture capital partners and seeks collaboration with rising firms to develop a broad technology portfolio. Its investor base includes leading private foundations, endowments, and institutional investors in the United States and Western Europe.

Mid-America Angels is a regional network of accredited investors that identifies and funds early-stage companies. It participates in seed, Series A, and Series B rounds depending on the capital raise and provides a framework to pool the members’ knowledge, experience, and investment capital. Founded in 2006, the organization is based in Kansas and Oklahoma and focuses on the Kansas-Missouri region around Kansas City, typically investing between $250,000 and $1,500,000 per opportunity.

Serac Ventures is a seed-stage venture capital firm founded in 2022 and based in Oklahoma City that invests in early-stage fintech, business-to-business software-as-a-service, and future-of-work companies, aiming to help founders overcome challenges and grow high-growth businesses in expansive markets.

Trailblazer Capital is a venture capital firm based in Dallas, Texas, that focuses on investing in seed/start-ups, early-stage companies, and growth capital. The firm primarily targets sectors such as networking and telecommunications, wireless and mobility services, software applications, database management, and enterprise software, with interests in security, cloud computing, e-commerce, and digital media. Established in 2006, Trailblazer Capital typically invests between $0.1 million and $5 million in companies, predominantly those located in Texas and Oklahoma. The firm deliberately avoids investments in life sciences, biotechnology, medical devices, real estate, and natural resources.

Davis Tuttle Venture Partners is an Oklahoma-based investment firm founded in 1986 and located in Tulsa, focused on growth companies across North America. The firm provides long-term development capital and offers management counsel and operational support to emerging growth businesses. It pursues traditional venture capital opportunities as well as acquisitions and other special opportunities, targeting companies driven by strong leadership and high growth potential. By assisting management in strategic decisions and applying disciplined policy guidance, the firm aims to create value and maximize investment returns as companies scale from expansion to late-stage development.

Founded in 2018 and based in Oklahoma City, Cameron Ventures is a venture capital firm that makes early-stage investments from pre-seed to Series A, focusing on insurtech, fintech, and enterprise technology applications, including decentralized finance and related technology sectors.

Apis Holdings is a venture capital firm based in Tulsa, Oklahoma, founded in 2017, that makes multi-stage investments in technology, data, and services.

Startup Capital Ventures is a California-based venture capital firm focused on early-stage B2B technology companies in the United States and China. Headquartered in Menlo Park and with an office in Honolulu, the firm targets software, fintech, healthtech, IoT, SaaS and related sectors, typically making initial investments around $0.25 million to $1 million and reserving capital for follow-on rounds. It emphasizes capital-efficient, revenue-generating companies and supports portfolio teams with hands-on operational guidance, leveraging an extensive professional network to help achieve milestones. The firm pursues partnerships with strong management teams and operates across Silicon Valley, Hawaii, Texas, Oklahoma, and parts of China, including a notable collaboration with SBI Holdings of Japan to extend its reach.

EnCap Investments is a private equity and venture capital firm founded in 1988 and headquartered in Houston, Texas, with an additional Dallas office. It specializes in investments across the oil and gas value chain, including upstream exploration and production, and midstream infrastructure such as natural gas pipelines, gathering, processing, compression, storage, and transportation. The firm also targets energy infrastructure and clean energy initiatives within the energy transition. It typically provides equity on a deal-by-deal basis, with typical investment sizes in the tens to hundreds of millions of dollars, and may support reserve acquisitions and drilling projects. Its geographic focus includes the United States, Canada, and Mexico. EnCap Investments pursues opportunities in early-stage to growth-oriented companies and is registered as an investment adviser, emphasizing partnerships with operators and infrastructure developers to build long-term value in the oil, gas, and energy services sectors.

Mercury Fund is a Houston-based venture capital firm that backs early-stage technology companies across the United States, with additional activity in Ann Arbor. It concentrates on software, SaaS, cloud, data, and artificial intelligence, and emphasizes an operationally oriented approach to accelerate growth. Mercury Fund partners with both first-time entrepreneurs and experienced founders, offering strategic guidance and access to a broad growth-partner network to help startups scale, particularly in Middle America and other midcontinent markets. The firm manages multiple early-stage funds and maintains a focus on technology-driven businesses.

Optum is a health services and innovation company dedicated to helping people live healthier lives. It designs a healthcare system that connects people, places, and ideas across the ecosystem to deliver personalized care, including medication, healthcare financial services, and guidance, along with technology and services for health plan providers. The company offers a broad range of medical services, including family medicine, internal medicine, pediatrics, women's health, substance use treatment, and mental health, as well as care for common conditions of the eyes, ears, skin, and nervous system. By integrating data, insights, and digital tools, Optum seeks to improve access, care coordination, and the efficiency of the medical system for patients, providers, and employers in collaboration with health plans and other partners.

Draper Associates is a venture capital firm that backs early-stage startups worldwide, investing from pre-seed to Series A and maintaining an industry-agnostic, opportunistic stance. It seeks transformative ideas across AI, robotics, biotech, fintech, crypto, space, defense, software as a service, cloud, new media, gaming, and other deep technologies, aiming to support teams with the potential to disrupt markets and drive substantial growth. The firm is headquartered in San Mateo, California.

UNC Kenan-Flagler Private Equity Fund is a student-run private equity fund affiliated with the University of North Carolina at Chapel Hill's Kenan-Flagler Business School. Founded in 2007 and based in Chapel Hill, North Carolina, it engages in private equity and venture capital activities across early and late stages, buyouts, growth capital, mezzanine financing, and real estate investments. The fund targets portfolio company investments of roughly $0.1 million to $0.15 million with enterprise values between $20 million and $125 million and co-invests with partner private investment firms. Operating in an educational setting, it aims to deliver real returns for investors while providing students with hands-on investment experience.

Hard Yaka is an investment firm based in Crystal Bay, Nevada. It engages in private equity and venture investments, focusing on technology and financial services sectors, including early-stage investments in exchange-related startups and opportunities in buyouts and distressed assets, often pursuing majority stakes.

Advantage Capital Partners is a private equity and venture capital firm founded in 1992 and headquartered in New Orleans, Louisiana, with additional offices across the United States. The firm specializes in equity and debt investments, including growth equity, senior and subordinated debt, and mezzanine financing, with a focus on small businesses and underserved communities. It collaborates with state and federal economic programs to support local economic development and has financed companies in sectors such as manufacturing, technology, business services, energy, and agribusiness, including renewable and solar projects. The firm targets opportunities across growth stages and aims to create lasting economic impact by expanding opportunity in low-income areas through private investment and public-private partnerships.

Germin8 Ventures is a multi-stage venture capital firm that invests in disruptive Food & AgTech companies across the value chain worldwide. It focuses on agrifood technology, frontier science, and computation with applications in agriculture, food, and nutrition. Supported by a group of industry veterans and sophisticated investors, the firm provides capital and strategic resources to transformative Food & Agriculture Technology ventures addressing major demand trends and aiming to improve the global food system through innovative technologies and solutions.

Russell Westbrook Enterprises is a company dedicated to supporting global communities through strategic investments and partnerships. It focuses on providing financial and investment management services aimed at inspiring and uplifting communities worldwide. By leveraging both economic and social capital, the company engages in ventures that positively impact businesses and communities. Through a combination of endorsements, equity stakes, and potential investments, Russell Westbrook Enterprises facilitates connections within the business landscape, promoting economic development. The firm aims to help corporations enhance brand awareness and differentiate themselves in the marketplace while exploring new opportunities for its portfolio companies.

1789 Capital is a Palm Beach, Florida-based growth equity firm founded in 2023 that provides venture and growth capital to middle-, late-, and crossover-stage companies operating in artificial intelligence, software, aerospace and defense, healthtech, and fintech. The firm concentrates on four areas: replication and the parallel economy, deglobalization, sectors adversely affected by ESG policies, and cutting-edge technologies that disrupt industries burdened by bureaucracy.

What If Ventures is a venture capital firm based in Frisco, Texas, that backs startups in healthcare and aerospace and defense. Founded by Stephen Hays around 2019–2020, the firm targets early-stage companies from seed to Series C and has deployed nearly $100 million across more than 80 healthcare startups. Hays' background as a U.S. Army veteran and West Point graduate, with prior experience in aerospace and defense investment banking, informs a focus on large, fragmented markets with complex regulation and significant government and commercial customers. The firm seeks to fund disruptive innovations that can improve lives or enhance safety, tackling industries where new entrants historically struggle to gain traction against established incumbents.

Initialized Capital is a San Francisco-based venture capital firm founded in 2012 that concentrates on early-stage technology investments, with a focus on seed opportunities. It manages multiple funds and has a team of investing partners, supporting technology startups through the initial funding stages.

OCA Ventures is a Chicago-based venture capital firm founded in 1999 that makes early-stage equity investments in technology-driven companies in the United States and Canada. The firm concentrates on software and information technology-enabled businesses, including consumer software, enterprise software, fintech, and digital health, with a preference for companies demonstrating dramatic growth potential and scalable models. By backing startups at seed to early-growth stages, OCA Ventures aims to support firms developing innovative software solutions and technology-enabled services across industries, including healthcare technology systems and financial services. The team seeks partnerships with entrepreneurs building scalable platforms and differentiated products, leveraging its regional presence and sector focus to add operational and strategic value.

Energy Spectrum Capital is a Dallas-based private equity firm that specializes in energy infrastructure and related services. Founded in 1995, it pursues investments across the energy value chain, including midstream assets, oil and gas infrastructure, energy services, and power development. The firm targets North American opportunities, primarily in the United States and Canada, and typically makes equity investments ranging from about 50 to 200 million with follow-on capital as needed. Investments are structured as buyouts, growth and early-stage ventures, with an intended exit horizon of three to seven years. Energy Spectrum Capital provides strategic guidance and operational insight to portfolio companies and aligns with institutional investors seeking exposure to energy infrastructure assets.

Mayo Clinic is a non-profit medical organization based in Rochester, Minnesota, established in 1863. It provides comprehensive medical care, education in clinical medicine and biomedical sciences, and conducts extensive medical research across a broad range of specialties. The organization integrates patient care with education and research to advance medical practice and outcomes. It also advances innovation through Mayo Clinic Platform, a Rochester-based accelerator that incubates and invests in early-stage health-tech startups in collaboration with providers, pharmaceutical and device companies, health-tech developers, and patients; and Mayo Clinic Ventures, the organization's venture arm that partners with physicians and scientists to commercialize inventions and discoveries to improve patient care and support Mayo’s education and research missions.

Cottonwood Technology Fund is a venture capital firm based in Santa Fe, New Mexico, focused on high-tech and deep-tech investments. It backs early-stage startups in photonics, optics, micro- and nanoelectronics, nanotechnology, sensor technology, health sciences and medtech, climate tech, energy transition, advanced materials, robotics, telecom, automotive, and related sectors. The firm targets opportunities in the Southwestern United States and Northern Europe and operates as a registered investment adviser.

Founded in 2021, Yellow Rocks! is a venture capital firm investing in early-stage companies with global expansion potential. They focus on disruptive technologies and aim for startups to reach $1 billion valuation. With a team distributed across the USA, Portugal, and Armenia, they leverage their collective experience from organizations like World Bank, IFC, Google, EPAM, MIT, Harvard, Stanford, Y Combinator, TechStars, MassChallenge, and 500 Startups.

Uncorrelated Ventures is a venture capital firm founded in 2019 by Salil Deshpande and headquartered in San Francisco, California. It backs early-stage companies focused on infrastructure software and seeks opportunities in related areas such as decentralized finance, cryptocurrency, blockchain, and fintech.

Stout Street Capital is a Denver, Colorado-based venture capital firm that backs early-stage technology companies. It concentrates on software and B2B SaaS, while also investing in fintech, advanced materials, robotics, and artificial intelligence. The firm targets opportunities in under-served markets in the central United States, with a particular emphasis on the Rocky Mountain region. Its approach combines data-driven analysis, market assessment, and thorough due diligence to select ventures that can improve efficiency and generate measurable value as they scale.

Lightship Capital is a venture capital firm based in Cincinnati, Ohio, with an additional presence in Indianapolis. It concentrates on seed to Series A investments in Midwest startups spanning artificial intelligence, consumer packaged goods, health tech and healthcare, e-commerce, sustainability, and related sectors. The firm prioritizes funding for ventures led by underrepresented founders, including BIPOC individuals, women, LGBTQ+ people, and people with disabilities, aiming to expand access to venture capital beyond traditional hubs. By focusing on the Midwest and regional economic growth, Lightship Capital seeks companies with strong growth potential that advance local communities while delivering meaningful returns for its investors.

KCRise Fund is a Kansas City, Missouri-based venture capital firm focused on early-stage investments in Kansas and western Missouri. Founded in 2016 as part of the KCRising initiative to build regional capacity and scale local businesses, it backs software, information technology, and business-to-business sectors, including SaaS, supply chain/logistics, digital health, GovTech, and HRTech, as well as energy, financial services, and healthcare. The firm typically participates in seed and early-stage rounds and co-invests with other institutional investors, with multiple vintages launched to support the region's growth.

Sound Ventures is a venture capital firm based in Beverly Hills, California, founded in 2015, that invests in technology companies at early and mid stages and operates as a registered investment adviser.

Victorum Capital is an angel network based in Oklahoma City, founded in 2019. The organization brings together a network of investors, entrepreneurs, and partners dedicated to identifying, funding, and supporting promising business opportunities in the region. Through collaboration and strategic partnerships, Victorum Capital aims to foster innovation and growth within the local entrepreneurial ecosystem.

Cubit Capital is a venture capital investment firm based in Dallas, Texas, founded in 2022. It provides capital and strategic support to a range of companies across different sectors.

Decisive Point is a New York-based venture capital firm founded in 2018 that invests in technology companies serving government, public safety, defense, and related sectors such as energy, security, health, and infrastructure. The firm supports founders pursuing challenging opportunities and helps navigate the federal market to deliver solutions for government and commercial customers. It aims to back early-stage ventures with capabilities to address national needs through technology and innovation.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, established in 2013. It targets individual accredited investors who previously had limited access to venture capital by enabling alumni from top entrepreneurial schools to invest together in ventures led by fellow alumni. The firm backs companies with an alumni connection and an institutional lead investor with sector expertise. It offers focused funds that provide accredited investors access to a diversified venture portfolio by type, sector, stage, and geography. The organization engages in seed, early-stage, and late-stage pre-IPO investments across technology, consumer, financial services, health care, life sciences, and other sectors.

Elephant Partners is a Boston-based venture capital firm that concentrates on early-stage investments in enterprise software and consumer internet companies, with additional focus on mobile technologies. The firm operates across the United States, targeting opportunities in technology, media, and telecommunications sectors and seeking to support growth-oriented startups through its early-stage capital and strategic guidance.

Tuesday Capital is a San Francisco-based venture capital firm that targets early-stage technology companies, with a focus on seed-stage investments in information technology-enabled businesses. Founded in 2011 as CrunchFund, the firm rebranded to Tuesday Capital in 2019 to continue funding emerging startups in the technology sector.

HG Ventures is the venture capital arm of The Heritage Group. It invests in early and growth-stage companies developing advanced materials and systems for transportation infrastructure, environmental services, and specialty chemicals, as well as digital systems relevant to these industries. The firm aims to partner with portfolio companies by leveraging The Heritage Group’s operating companies and research center to provide technical expertise, manufacturing capabilities, and expansive industry networks. HG Ventures focuses on opportunities in the United States, typically backing companies positioned to improve infrastructure resilience, environmental performance, and energy production through innovative materials and processes. Through its strategic support, the firm helps portfolio companies scale and integrate with real-world supply chains and customers.

Elevate Ventures is a not-for-profit organization based in Indiana that nurtures and develops emerging and existing high-potential businesses into high-performing Indiana-based companies. It conducts rigorous business analysis and provides robust advisory services, connecting companies with resources needed for long-term success. Beyond capital, Elevate Ventures partners with entrepreneurs, investors, and local and state organizations to address barriers such as management, business development, talent identification and retention, and technology development challenges. The organization emphasizes unbiased, in-depth perspectives and objective recommendations through a seasoned staff and external partners, supporting growth, job creation, and economic development in Indiana. It seeks ventures identifying marketplace needs and capable of transitioning from research to product development to market, aiming to sustain business success over time.

Kapor Capital is an Oakland, California-based venture capital firm that serves as the investing arm of the Kapor Center for Social Impact. It focuses on seed and early-stage tech-enabled startups that can generate positive social impact, with emphasis on platforms and information technology that address urgent social needs. The firm backs companies across sectors including education, health, fintech, work, finance, justice, environment, food, and consumer services, often prioritizing diversity and inclusive business models and supporting minority- and women-owned ventures. It operates primarily in the United States and seeks investments that combine financial returns with social outcomes, aiming to close gaps in access and opportunity.

Merck KGaA is a German chemical and pharmaceutical company founded in 1668 in Darmstadt, making it one of the oldest continuously operating companies in its sector. It operates across three main segments: Life Science, Electronics and Healthcare. The Life Science segment provides laboratory consumables and instruments to researchers in academia and industry; the Electronics segment supplies specialty materials for semiconductors and display technologies; the Healthcare segment develops and sells branded pharmaceuticals with therapeutic areas including oncology, multiple sclerosis and fertility. The group markets primarily under the Merck name outside the United States and Canada, where regional rights are held by Merck & Co and the company operates via units such as EMD Serono, MilliporeSigma and EMD Electronics. Headquartered in Darmstadt, Merck KGaA maintains a global presence across Europe, Africa, Asia, Oceania and Latin America, reflecting its long history of scientific innovation and international expansion.

Revolution is a Washington, D.C.–based venture capital firm founded in 2005 by Steve Case. It backs technology-enabled companies at early and growth stages across the United States, with a focus on software, information technology, media and entertainment, financial services, health, energy, consumer products, e-commerce, education, and travel. The firm partners with entrepreneurs to build disruptive businesses, often taking leadership roles on boards and providing strategic support to accelerate growth. It maintains an emphasis on investing across diverse geographies, reflecting a belief that strong companies can emerge from non-coastal regions and that startup hubs outside traditional centers can yield high impact opportunities. Revolution operates multiple venture platforms and maintains a presence in Washington, D.C. and San Francisco, collaborating with founders to create enduring value for customers and investors.

Greycroft is a venture capital firm based in New York and Los Angeles that concentrates on technology startups, with a focus on the Internet and mobile markets. The firm uses its extensive media and technology industry connections to help entrepreneurs gain visibility, build strategic relationships, bring products to market, and scale successful businesses. Since inception Greycroft has invested in more than 200 companies and manages over $1 billion in capital. Its investment scope spans consumer internet, fintech, healthcare, and enterprise software, reflecting a broad approach to funding early- and growth-stage ventures in technology sectors.