Innovation Works

Advanced Optronics specializes in the design and manufacture of implantable sensors aimed at enhancing intraoperative monitoring during surgeries. These innovative sensors provide real-time feedback to surgeons, helping to minimize trauma and prevent damage to residual hearing during implant procedures. The company focuses on developing flexible and biocompatible sensor systems that facilitate less invasive surgical techniques across various medical applications. By integrating flexible micro-electromechanical system sensors with cochlear implants, Advanced Optronics aims to improve surgical outcomes and support surgeons in performing procedures with greater precision and care.

Rimsys is a leading provider of Regulatory Information Management (RIM) software tailored for medical technology companies. Designed by regulatory affairs professionals, Rimsys offers a cloud-based solution that digitizes and automates compliance processes to ensure adherence to evolving global regulations. This comprehensive software simplifies the management of global Unique Device Identification (UDI) requirements and supports various aspects of regulatory affairs, including product registration, standards management, and regulatory intelligence. By enabling medical device companies to efficiently track product registrations and monitor relevant standards, Rimsys transforms regulatory compliance into a more organized and manageable process for teams and their international partners.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

HeadStrait Labs is a medical equipment manufacturing company that focuses on developing devices for head and neck immobilization in pre-hospital care. The firm offers a specialized head device designed to enhance patient outcomes during ambulance transportation. By enabling healthcare professionals to effectively stabilize the head and neck during critical moments, HeadStrait Labs plays a vital role in improving care for patients in emergency situations.

Humotech is a developer of a wearable robotics platform that focuses on advancing research and development in areas such as prosthetics, orthotics, and exoskeletons. The company offers a system known as Caplex, which allows users to explore and innovate with reduced risk and shorter development timelines. Caplex serves as a programmable performance system that emulates real-world physical characteristics, enabling researchers to test their ideas before committing to physical prototypes. This platform provides high-performance, customizable, and expandable hardware and software, thereby facilitating the rapid development, testing, and evaluation of wearable assistive technology concepts with human users.

Testa-Seat specializes in developing affordable, adaptable seating solutions for children with special needs, utilizing tailored 3D printing technology. The company's products are designed to enhance mobility and independence for individuals with disabilities. Testa-Seat's body-contouring therapeutic seating provides optimal support for those with mild to moderate body control, helping to reduce the risks associated with improper seating during child development. By delivering its innovative seating devices to rehabilitation centers, hospitals, and private customers, Testa-Seat aims to improve comfort and wellness for disabled children and adults, positively impacting their mobility and overall quality of life for both individuals and their families.

Resilient Lifescience focuses on the development of a wearable medical device aimed at preventing opioid overdose deaths. The device is designed to detect overdose events and automatically administer naloxone, a medication that can reverse the effects of an opioid overdose. This innovative technology empowers individuals to respond to overdose situations effectively, even in the absence of immediate assistance from others, thereby enhancing patient safety and potentially saving lives.

Magnify Biosciences specializes in advanced microscopy solutions, offering a high-resolution imaging platform and associated services. Their technology physically expands biological samples, enabling researchers to study complex structures and molecular interactions at the nanoscale, beyond the typical limits of light microscopy. This empowers researchers, entrepreneurs, and diagnostic labs to gain unique insights into cellular architecture, facilitating advancements in life sciences and diagnostics.

D.Sole specializes in the development of advanced foot insoles aimed at improving remote patient monitoring in podiatry, specifically for diabetic patients. These innovative, AI-powered insoles utilize multimodal sensors to detect early signs of complications, such as ulcers and nerve damage. By providing comprehensive physiological data, D.Sole enables clinicians to gain evidence-based insights for more effective foot treatments. The company's solution is notably more cost-effective than existing market options, detecting multiple foot complications compared to competitors that typically identify only one. This technology has the potential to significantly reduce healthcare costs, potentially saving hospitals over $100 million annually by decreasing readmission rates for foot complications, while private insurers could save more than $1 billion by minimizing expenses related to amputations and wound care.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

Push2Spin Technologies is engaged in the development and commercialization of innovative solutions in plastic and podiatric surgeries. The company is focused on transforming the global soft tissue grafting market through its novel approach to small-volume fat tissue harvesting, processing, and transfer. By introducing disruptive technologies, Push2Spin aims to enhance clinical efficiency, streamline procedural workflows, and reduce associated time and costs for healthcare providers.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

InnSight Technology is a biotechnology company focused on enhancing diagnostics and evaluation of eye diseases. The company develops innovative ophthalmic devices, including a novel hand-held biosensor designed for the detection of anterior ophthalmic injuries. Additionally, InnSight Technology works on advanced nanotechnology-based medical devices aimed at addressing specific clinical needs in ophthalmology. By providing these tools, the company seeks to improve ocular care for clinicians and their patients.

Respair is a medical device company focused on developing innovative airway products designed for critical care environments. The company's technology aims to enhance patient safety and comfort by replacing traditional inflatable cuffs on breathing tubes with soft, pliable baffles. These baffles function as effective stoppers, providing a comprehensive seal for the airway without exerting additional pressure. This design minimizes the risk of secondary complications, allowing patients to breathe more easily and safely during critical medical situations. Respair's products are intended to support clinicians in delivering high-quality care while improving patient outcomes.

Gus Gear specializes in the development and manufacturing of wearable securement clothing designed to protect implanted medical devices. The company's flagship product, the Central Line Vest, effectively prevents damage, breakage, and accidental removal of central catheters. By providing securement solutions for various medical devices, including ostomy pouches and feeding tubes, Gus Gear aims to enhance patient outcomes and quality of life. Their innovative approach enables patients to maintain a higher level of independence and well-being while undergoing medical treatment, allowing them to live their lives to the fullest despite any health challenges.

PECA Labs, Inc. is a medical device company based in Pittsburgh, Pennsylvania, focused on developing innovative solutions for pediatric cardiovascular care. Its primary product, the MASA Valve, is a synthetic heart valve designed for right ventricular outflow tract reconstruction in children. Utilizing advanced material properties of ePTFE, the MASA Valve addresses limitations associated with existing conduits, offering improved outcomes and reduced need for re-operation. This device has received Humanitarian Use Device designation from the FDA and has been successfully implanted in numerous patients. Additionally, PECA Labs offers exGraft, an ePTFE vascular graft marked for enhanced visibility during procedures. Founded as a spin-off from Carnegie Mellon University and UPMC, the company aims to enhance the quality of life for children with cardiac defects while minimizing the surgical interventions they face throughout their development.

Advanced Optronics specializes in the design and manufacture of implantable sensors aimed at enhancing intraoperative monitoring during surgeries. These innovative sensors provide real-time feedback to surgeons, helping to minimize trauma and prevent damage to residual hearing during implant procedures. The company focuses on developing flexible and biocompatible sensor systems that facilitate less invasive surgical techniques across various medical applications. By integrating flexible micro-electromechanical system sensors with cochlear implants, Advanced Optronics aims to improve surgical outcomes and support surgeons in performing procedures with greater precision and care.

Telling.ai is a telehealth platform focused on assessing lung health through the analysis of voice and breath sounds. By capturing respiratory sounds in real-world settings, the company provides real-time feedback and optimizes data quality to support individuals with chronic lung conditions. Their technology identifies signatures in breath and speech that indicate various medical conditions, including respiratory diseases and infections. Telling.ai aims to assist in the management of care for over 1 billion people suffering from acute or chronic respiratory disorders, enabling timely interventions that can prevent costly hospitalizations and improve overall patient outcomes.

Emergence Dental is a research and development medical device company established in 2019 and headquartered in Pittsburgh, USA. The company specializes in the design and pre-clinical development of innovative medical devices aimed at improving dental bone and soft tissue grafting procedures. Emergence Dental offers products made from metallic magnesium alloys, which safely resorb when implanted in the body. This technology enables oral surgeons and periodontists to reduce both the time and costs associated with dental bone grafting procedures for patients preparing to receive dental implants.

Lumis specializes in advanced healthcare education by providing next-generation learning systems that enhance patient care. The company focuses on immersive, simulation-based training that incorporates augmented reality and automated instruction, allowing for individualized and on-demand learning accessible 24/7. Their technology is designed to transform traditional clinical training experiences into engaging and efficient learning opportunities. Lumis’ products can be integrated with various training mannequins, accommodating a wide range of budgets and training needs, from basic models to sophisticated, computer-controlled systems. By ensuring that high-quality training is available to healthcare professionals anytime and anywhere, Lumis aims to improve the preparation of clinicians for life-critical operations.

Element Exo specializes in the design and development of lightweight exoskeletons aimed at facilitating lifting and bending tasks for workers. The company's innovative technology focuses on assisting users by storing energy during bending movements and releasing it when standing up, all without the need for motors, batteries, or electricity. This approach not only enhances the ease of physical tasks but also significantly reduces the risk of overuse injuries related to repetitive lifting. By improving the health and well-being of wearers, Element Exo's products help mitigate the financial and time losses associated with debilitating back injuries, ultimately leading to increased productivity in the workplace.

Rimsys is a leading provider of Regulatory Information Management (RIM) software tailored for medical technology companies. Designed by regulatory affairs professionals, Rimsys offers a cloud-based solution that digitizes and automates compliance processes to ensure adherence to evolving global regulations. This comprehensive software simplifies the management of global Unique Device Identification (UDI) requirements and supports various aspects of regulatory affairs, including product registration, standards management, and regulatory intelligence. By enabling medical device companies to efficiently track product registrations and monitor relevant standards, Rimsys transforms regulatory compliance into a more organized and manageable process for teams and their international partners.

Telling.ai is a telehealth platform focused on assessing lung health through the analysis of voice and breath sounds. By capturing respiratory sounds in real-world settings, the company provides real-time feedback and optimizes data quality to support individuals with chronic lung conditions. Their technology identifies signatures in breath and speech that indicate various medical conditions, including respiratory diseases and infections. Telling.ai aims to assist in the management of care for over 1 billion people suffering from acute or chronic respiratory disorders, enabling timely interventions that can prevent costly hospitalizations and improve overall patient outcomes.

Hava Health, Inc. is a biotechnology company based in the United States that specializes in developing innovative solutions for nicotine addiction. The company manufactures a smoking cessation device that includes a connected vape pen designed to assist individuals in their efforts to quit smoking. This device pairs with a smartphone application called Hale, which serves as a digital support tool for users undergoing nicotine de-addiction. Through its focus on combining technology with therapeutic approaches, Hava Health aims to provide effective support for those seeking to overcome nicotine dependence.

PECA Labs, Inc. is a medical device company based in Pittsburgh, Pennsylvania, focused on developing innovative solutions for pediatric cardiovascular care. Its primary product, the MASA Valve, is a synthetic heart valve designed for right ventricular outflow tract reconstruction in children. Utilizing advanced material properties of ePTFE, the MASA Valve addresses limitations associated with existing conduits, offering improved outcomes and reduced need for re-operation. This device has received Humanitarian Use Device designation from the FDA and has been successfully implanted in numerous patients. Additionally, PECA Labs offers exGraft, an ePTFE vascular graft marked for enhanced visibility during procedures. Founded as a spin-off from Carnegie Mellon University and UPMC, the company aims to enhance the quality of life for children with cardiac defects while minimizing the surgical interventions they face throughout their development.

Lumis specializes in advanced healthcare education by providing next-generation learning systems that enhance patient care. The company focuses on immersive, simulation-based training that incorporates augmented reality and automated instruction, allowing for individualized and on-demand learning accessible 24/7. Their technology is designed to transform traditional clinical training experiences into engaging and efficient learning opportunities. Lumis’ products can be integrated with various training mannequins, accommodating a wide range of budgets and training needs, from basic models to sophisticated, computer-controlled systems. By ensuring that high-quality training is available to healthcare professionals anytime and anywhere, Lumis aims to improve the preparation of clinicians for life-critical operations.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

Emergence Dental is a research and development medical device company established in 2019 and headquartered in Pittsburgh, USA. The company specializes in the design and pre-clinical development of innovative medical devices aimed at improving dental bone and soft tissue grafting procedures. Emergence Dental offers products made from metallic magnesium alloys, which safely resorb when implanted in the body. This technology enables oral surgeons and periodontists to reduce both the time and costs associated with dental bone grafting procedures for patients preparing to receive dental implants.

JuneBrain, LLC is a Washington, D.C.-based company founded in 2017 that focuses on developing wearable and non-invasive imaging devices for multiple sclerosis patients. The technology allows patients to monitor their disease activity from home, facilitating earlier detection of MS attacks and enhancing the monitoring of treatment efficacy. By leveraging telemedicine, JuneBrain aims to optimize remote assessment for neurological diseases, thereby enabling clinicians to track patients outside traditional clinical settings. The company's long-term vision includes extending its device's applications to a broader range of neurodegenerative diseases, promoting more accessible and frequent monitoring of brain health.

Gus Gear specializes in the development and manufacturing of wearable securement clothing designed to protect implanted medical devices. The company's flagship product, the Central Line Vest, effectively prevents damage, breakage, and accidental removal of central catheters. By providing securement solutions for various medical devices, including ostomy pouches and feeding tubes, Gus Gear aims to enhance patient outcomes and quality of life. Their innovative approach enables patients to maintain a higher level of independence and well-being while undergoing medical treatment, allowing them to live their lives to the fullest despite any health challenges.

SwifTAG Systems concepts and products were conceived by active researchers in the medical field who recognized the dramatic inefficiencies of existing small animal management systems and processes. Their mission is to bring high technology and medical research together to drive down costs and increase the time researchers spend doing actual research. They envision laboratories where animal management systems are functional, low maintenance, efficient, and as easy to use as a well-designed smartphone app. They want to see researchers focusing on medical breakthroughs, not on mindless small animal logistics. Their product lines include small animal tags, handheld and tabletop readers, cage and rack readers, whole laboratory management systems, and support software.

Lumis specializes in advanced healthcare education by providing next-generation learning systems that enhance patient care. The company focuses on immersive, simulation-based training that incorporates augmented reality and automated instruction, allowing for individualized and on-demand learning accessible 24/7. Their technology is designed to transform traditional clinical training experiences into engaging and efficient learning opportunities. Lumis’ products can be integrated with various training mannequins, accommodating a wide range of budgets and training needs, from basic models to sophisticated, computer-controlled systems. By ensuring that high-quality training is available to healthcare professionals anytime and anywhere, Lumis aims to improve the preparation of clinicians for life-critical operations.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

Connect Wolf, Inc. is a Pittsburgh-based company founded in 2017 that specializes in manufacturing wearable devices for tracking individuals, including babies, children, and adults. The company's innovative modular wearable provides real-time location and heart rate information, eliminating the need for additional devices to connect via Bluetooth or WiFi. This technology aims to give caregivers peace of mind by allowing them to monitor the well-being of their loved ones, whether in a nursery, senior center, or healthcare facility. Additionally, Connect Wolf offers family tracking options for use in various public venues such as amusement parks and zoos, catering to the needs of parents seeking reassurance about their children's safety. The company also develops an accompanying application to enhance the tracking experience and facilitate monitoring activities.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

Gus Gear specializes in the development and manufacturing of wearable securement clothing designed to protect implanted medical devices. The company's flagship product, the Central Line Vest, effectively prevents damage, breakage, and accidental removal of central catheters. By providing securement solutions for various medical devices, including ostomy pouches and feeding tubes, Gus Gear aims to enhance patient outcomes and quality of life. Their innovative approach enables patients to maintain a higher level of independence and well-being while undergoing medical treatment, allowing them to live their lives to the fullest despite any health challenges.

Symmetric Health Solutions LLC is a company that specializes in the development of software and analytics platforms tailored for the healthcare medical supplies industry. Founded in 2018 and headquartered in Pittsburgh, Pennsylvania, with additional offices in New York and Washington, the company provides comprehensive supply chain data solutions that include the management of medical devices and pharmaceuticals, as well as research reports, price benchmarking, and product standardization. Its platform allows healthcare providers to identify cost-saving opportunities and assess supply chain risks through data intelligence and professional support services. Key features of its offerings include value analysis standardization, data management, and tools for tracking historical adverse events, all aimed at enhancing operational efficiency and reducing errors in healthcare supply chains.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

nanoGriptech, Inc. specializes in manufacturing micro-fibrillar polymer-based dry adhesives and surfaces, drawing inspiration from the natural adhesion mechanism of gecko feet. Founded in 2012 and headquartered in Pittsburgh, Pennsylvania, the company offers a range of products, including the Setex Gecko Tape, which is a repeatable, residue-free, non-tacky tape, and the Setex Ultra-Thin Fastener, designed for seamless integration with smooth surfaces. Its innovative adhesive solutions are tailored for diverse applications such as wearables, sports gear, semiconductors, robotics, medical devices, automotive components, and packaging. nanoGriptech aims to provide a superior alternative to traditional reusable adhesives, focusing on durability and customization. The company has established partnerships with multinational corporations and has recently begun small volume sales in the high-friction clothing market.

SwifTAG Systems concepts and products were conceived by active researchers in the medical field who recognized the dramatic inefficiencies of existing small animal management systems and processes. Their mission is to bring high technology and medical research together to drive down costs and increase the time researchers spend doing actual research. They envision laboratories where animal management systems are functional, low maintenance, efficient, and as easy to use as a well-designed smartphone app. They want to see researchers focusing on medical breakthroughs, not on mindless small animal logistics. Their product lines include small animal tags, handheld and tabletop readers, cage and rack readers, whole laboratory management systems, and support software.

Lumis specializes in advanced healthcare education by providing next-generation learning systems that enhance patient care. The company focuses on immersive, simulation-based training that incorporates augmented reality and automated instruction, allowing for individualized and on-demand learning accessible 24/7. Their technology is designed to transform traditional clinical training experiences into engaging and efficient learning opportunities. Lumis’ products can be integrated with various training mannequins, accommodating a wide range of budgets and training needs, from basic models to sophisticated, computer-controlled systems. By ensuring that high-quality training is available to healthcare professionals anytime and anywhere, Lumis aims to improve the preparation of clinicians for life-critical operations.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

Symmetric Health Solutions LLC is a company that specializes in the development of software and analytics platforms tailored for the healthcare medical supplies industry. Founded in 2018 and headquartered in Pittsburgh, Pennsylvania, with additional offices in New York and Washington, the company provides comprehensive supply chain data solutions that include the management of medical devices and pharmaceuticals, as well as research reports, price benchmarking, and product standardization. Its platform allows healthcare providers to identify cost-saving opportunities and assess supply chain risks through data intelligence and professional support services. Key features of its offerings include value analysis standardization, data management, and tools for tracking historical adverse events, all aimed at enhancing operational efficiency and reducing errors in healthcare supply chains.

PECA Labs, Inc. is a medical device company based in Pittsburgh, Pennsylvania, focused on developing innovative solutions for pediatric cardiovascular care. Its primary product, the MASA Valve, is a synthetic heart valve designed for right ventricular outflow tract reconstruction in children. Utilizing advanced material properties of ePTFE, the MASA Valve addresses limitations associated with existing conduits, offering improved outcomes and reduced need for re-operation. This device has received Humanitarian Use Device designation from the FDA and has been successfully implanted in numerous patients. Additionally, PECA Labs offers exGraft, an ePTFE vascular graft marked for enhanced visibility during procedures. Founded as a spin-off from Carnegie Mellon University and UPMC, the company aims to enhance the quality of life for children with cardiac defects while minimizing the surgical interventions they face throughout their development.

Lumis specializes in advanced healthcare education by providing next-generation learning systems that enhance patient care. The company focuses on immersive, simulation-based training that incorporates augmented reality and automated instruction, allowing for individualized and on-demand learning accessible 24/7. Their technology is designed to transform traditional clinical training experiences into engaging and efficient learning opportunities. Lumis’ products can be integrated with various training mannequins, accommodating a wide range of budgets and training needs, from basic models to sophisticated, computer-controlled systems. By ensuring that high-quality training is available to healthcare professionals anytime and anywhere, Lumis aims to improve the preparation of clinicians for life-critical operations.

nanoGriptech, Inc. specializes in manufacturing micro-fibrillar polymer-based dry adhesives and surfaces, drawing inspiration from the natural adhesion mechanism of gecko feet. Founded in 2012 and headquartered in Pittsburgh, Pennsylvania, the company offers a range of products, including the Setex Gecko Tape, which is a repeatable, residue-free, non-tacky tape, and the Setex Ultra-Thin Fastener, designed for seamless integration with smooth surfaces. Its innovative adhesive solutions are tailored for diverse applications such as wearables, sports gear, semiconductors, robotics, medical devices, automotive components, and packaging. nanoGriptech aims to provide a superior alternative to traditional reusable adhesives, focusing on durability and customization. The company has established partnerships with multinational corporations and has recently begun small volume sales in the high-friction clothing market.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

ThoroughCare, Inc. is a provider of web-based software solutions focused on managing Medicare's preventive programs, including chronic care management and annual wellness visits. Founded in 2013 and headquartered in Rock Hill, South Carolina, the company aims to enhance the quality of patient care through its digital healthcare platform. ThoroughCare's tools are designed to integrate seamlessly with existing software systems, allowing healthcare providers of all sizes to implement effective patient assessment solutions. By promoting targeted care management and wellness services, ThoroughCare seeks to improve patient engagement and overall health outcomes, thereby supporting medical professionals in delivering high-quality care.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

PECA Labs, Inc. is a medical device company based in Pittsburgh, Pennsylvania, focused on developing innovative solutions for pediatric cardiovascular care. Its primary product, the MASA Valve, is a synthetic heart valve designed for right ventricular outflow tract reconstruction in children. Utilizing advanced material properties of ePTFE, the MASA Valve addresses limitations associated with existing conduits, offering improved outcomes and reduced need for re-operation. This device has received Humanitarian Use Device designation from the FDA and has been successfully implanted in numerous patients. Additionally, PECA Labs offers exGraft, an ePTFE vascular graft marked for enhanced visibility during procedures. Founded as a spin-off from Carnegie Mellon University and UPMC, the company aims to enhance the quality of life for children with cardiac defects while minimizing the surgical interventions they face throughout their development.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

Accel Diagnostics, LLC specializes in developing innovative medical diagnostics technologies focused on enhancing patient care and monitoring. The company has created the pScreen Card, a disposable, credit card-sized mobile-enabled blood diagnostic platform that accurately detects and quantifies various biomarkers within 30 minutes. This rapid diagnostic capability provides significant improvements in the management of infectious and chronic diseases at the point-of-care while reducing costs. Additionally, Accel Diagnostics is advancing a heart failure test designed for primary care physicians and home patient monitoring, allowing patients to monitor their heart health comfortably at home. This groundbreaking approach enables timely interventions before physical symptoms arise, thereby minimizing the risk of life-threatening events and reducing the frequency of hospitalizations. Founded in 2008 and based in Pittsburgh, Pennsylvania, Accel Diagnostics was previously known as Tropical Health Systems LLC.

nanoGriptech, Inc. specializes in manufacturing micro-fibrillar polymer-based dry adhesives and surfaces, drawing inspiration from the natural adhesion mechanism of gecko feet. Founded in 2012 and headquartered in Pittsburgh, Pennsylvania, the company offers a range of products, including the Setex Gecko Tape, which is a repeatable, residue-free, non-tacky tape, and the Setex Ultra-Thin Fastener, designed for seamless integration with smooth surfaces. Its innovative adhesive solutions are tailored for diverse applications such as wearables, sports gear, semiconductors, robotics, medical devices, automotive components, and packaging. nanoGriptech aims to provide a superior alternative to traditional reusable adhesives, focusing on durability and customization. The company has established partnerships with multinational corporations and has recently begun small volume sales in the high-friction clothing market.

Accel Diagnostics, LLC specializes in developing innovative medical diagnostics technologies focused on enhancing patient care and monitoring. The company has created the pScreen Card, a disposable, credit card-sized mobile-enabled blood diagnostic platform that accurately detects and quantifies various biomarkers within 30 minutes. This rapid diagnostic capability provides significant improvements in the management of infectious and chronic diseases at the point-of-care while reducing costs. Additionally, Accel Diagnostics is advancing a heart failure test designed for primary care physicians and home patient monitoring, allowing patients to monitor their heart health comfortably at home. This groundbreaking approach enables timely interventions before physical symptoms arise, thereby minimizing the risk of life-threatening events and reducing the frequency of hospitalizations. Founded in 2008 and based in Pittsburgh, Pennsylvania, Accel Diagnostics was previously known as Tropical Health Systems LLC.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

nanoGriptech, Inc. specializes in manufacturing micro-fibrillar polymer-based dry adhesives and surfaces, drawing inspiration from the natural adhesion mechanism of gecko feet. Founded in 2012 and headquartered in Pittsburgh, Pennsylvania, the company offers a range of products, including the Setex Gecko Tape, which is a repeatable, residue-free, non-tacky tape, and the Setex Ultra-Thin Fastener, designed for seamless integration with smooth surfaces. Its innovative adhesive solutions are tailored for diverse applications such as wearables, sports gear, semiconductors, robotics, medical devices, automotive components, and packaging. nanoGriptech aims to provide a superior alternative to traditional reusable adhesives, focusing on durability and customization. The company has established partnerships with multinational corporations and has recently begun small volume sales in the high-friction clothing market.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

RE2 Robotics, based in Pittsburgh, PA, is a Carnegie Mellon University spin-off founded in 2001 by Jorgen Pedersen. The company specializes in developing intelligent mobile manipulation systems designed for various industries, including defense, aviation, construction, energy, and healthcare. RE2 Robotics creates manipulator arms that offer human-like performance and intuitive interfaces, allowing users to remotely perform tasks in challenging environments, whether on the ground, in the air, or underwater. With a significant focus on military applications, over 400 of its robotic arms have been deployed for explosive ordnance disposal missions, enhancing safety and efficiency while reducing operational costs. The company's innovative technologies aim to save lives and improve the quality of life through advanced robotics.

ActivAided Orthotics LLC specializes in the design and development of biofunctional apparel aimed at improving body mechanics and correcting posture to alleviate pain. The company's flagship product, the ActivAided posture training shirt, is designed to address daily imbalances that contribute to back pain. Its innovative approach targets various conditions, including ankylosing spondylitis, spinal stenosis, and low back pain, by promoting rehabilitative habits and behaviors. Founded in 2011 and based in Pittsburgh, Pennsylvania, ActivAided Orthotics collaborates with medical professionals and engineers to create solutions that enable individuals to remain active and pain-free. Products are available for purchase through the company's online store and authorized healthcare providers. As of 2016, ActivAided operates as a subsidiary of Elizur Corporation.

Liquid X is a company specializing in the development of innovative metallic inks that enable the printing of functional components for various electronic devices. Their inks, which contain actual metal atoms rather than nanoparticles or metal flakes, offer superior properties such as high conductivity, thin and precise features, and excellent adhesion. This unique formulation allows for low-temperature processing and short production times, making it possible to use a wide range of substrates, including paper, gauze, and flexible plastics. Liquid X collaborates with manufacturers in the electronics industry to create applications such as sensors, heating elements, and smart textiles. The versatility of their inks supports various deposition methods, including inkjet, flexography, and gravure, positioning Liquid X as a key player in the emerging market for advanced electronic materials.

PECA Labs, Inc. is a medical device company based in Pittsburgh, Pennsylvania, focused on developing innovative solutions for pediatric cardiovascular care. Its primary product, the MASA Valve, is a synthetic heart valve designed for right ventricular outflow tract reconstruction in children. Utilizing advanced material properties of ePTFE, the MASA Valve addresses limitations associated with existing conduits, offering improved outcomes and reduced need for re-operation. This device has received Humanitarian Use Device designation from the FDA and has been successfully implanted in numerous patients. Additionally, PECA Labs offers exGraft, an ePTFE vascular graft marked for enhanced visibility during procedures. Founded as a spin-off from Carnegie Mellon University and UPMC, the company aims to enhance the quality of life for children with cardiac defects while minimizing the surgical interventions they face throughout their development.

Accel Diagnostics, LLC specializes in developing innovative medical diagnostics technologies focused on enhancing patient care and monitoring. The company has created the pScreen Card, a disposable, credit card-sized mobile-enabled blood diagnostic platform that accurately detects and quantifies various biomarkers within 30 minutes. This rapid diagnostic capability provides significant improvements in the management of infectious and chronic diseases at the point-of-care while reducing costs. Additionally, Accel Diagnostics is advancing a heart failure test designed for primary care physicians and home patient monitoring, allowing patients to monitor their heart health comfortably at home. This groundbreaking approach enables timely interventions before physical symptoms arise, thereby minimizing the risk of life-threatening events and reducing the frequency of hospitalizations. Founded in 2008 and based in Pittsburgh, Pennsylvania, Accel Diagnostics was previously known as Tropical Health Systems LLC.

ActivAided Orthotics LLC specializes in the design and development of biofunctional apparel aimed at improving body mechanics and correcting posture to alleviate pain. The company's flagship product, the ActivAided posture training shirt, is designed to address daily imbalances that contribute to back pain. Its innovative approach targets various conditions, including ankylosing spondylitis, spinal stenosis, and low back pain, by promoting rehabilitative habits and behaviors. Founded in 2011 and based in Pittsburgh, Pennsylvania, ActivAided Orthotics collaborates with medical professionals and engineers to create solutions that enable individuals to remain active and pain-free. Products are available for purchase through the company's online store and authorized healthcare providers. As of 2016, ActivAided operates as a subsidiary of Elizur Corporation.

Summit Materials offers advanced materials and near-net shape manufacturing processes that save companies time and money in demanding industries such as aerospace, medical devices and oil exploration. Our patented SM-100™ alloy is used where corrosion and wear resistance are needed simultaneously. Efficient use of raw materials ensures minimal waste and environmental impact.

ViaTherm Therapeutics LLC is a Pittsburgh-based company that specializes in the design and manufacture of medical devices aimed at alleviating chronic pain, muscle injuries, and joint immobility associated with aging. The company is recognized for its innovative diathermy technology, which provides therapeutic deep heating products that deliver non-invasive pain relief. ViaTherm's offerings include a therapeutic heating system, a deep-heat therapy system, and consumer pain management solutions. These devices are designed to promote flexibility, enhance circulation, and support the body's natural recovery processes, making them suitable for use in long-term care, rehabilitation, and physical therapy, as well as at-home pain management. ViaTherm Therapeutics is dedicated to delivering high-quality products that ensure customer safety and satisfaction.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

Rinovum Women's Health, Inc. develops medical devices for women. It offers Stork, a medical device that aids in natural fertility and conception in the privacy of home.

ThermalTherapeutic Systems was founded in June, 2006 by a team of highly respected experts in the field of hyperthermic perfusion technology, medical device manufacturing, molecular diagnostics and technology commercialization.

Fluorous Technologies, Inc. is a chemical technology company focused on developing and commercializing fluorous products for the life sciences sector. The company offers a range of products, including solid-phase extraction (SPE) cartridges, high-performance liquid chromatography (HPLC) columns, and various sorbent materials, as well as a selection of fluorous homologs and biomolecule tags. These products are designed to enhance the synthesis, separation, and immobilization of chemical entities from both synthetic and natural mixtures. Fluorous Technologies employs its patented technology to address challenges in drug discovery and development, providing solutions across the entire process. Additionally, the company engages in service contracts, licenses, and collaborations to leverage its technology. Founded in 2000 and headquartered in Ambridge, Pennsylvania, Fluorous Technologies operates as a subsidiary of Boron Specialties LLC.