Lionheart Ventures

Piramidal is a technology company specializing in artificial intelligence software for neurological health. It converts brain activity data into user-friendly health information, aiding in the diagnosis of various neurological diseases. The company's AI platform aims to enhance neurological diagnosis, treatment, and monitoring, providing swift and accurate patient assessments.

Xylo Bio is a drug development company focused on next-generation psychedelic-inspired therapeutics for psychiatric and neurological disorders. Through a psychedelic therapeutic platform, it aims to develop non-hallucinogenic, rapid-acting medicines that can be widely available and provide improvements over current SSRI treatments. The company seeks to rewire neural circuits and restore brain function, enabling clinicians to optimize care and expand treatment options beyond traditional antidepressants.

Clerkenwell Health is a mental health company providing clinical research support services and psychedelic-assisted therapies. It operates as a psychedelic-specialist contract research organization focused on psychiatry and central nervous system conditions, delivering independent CRO services to advance the adoption of psychedelic treatments in Europe. The company runs a healthcare clinic offering preparation, treatment sessions, and follow-up by experienced psychotherapists, and it collaborates to produce robust, clinically validated data sets that demonstrate the efficacy of psilocybin-assisted therapy relative to existing standards of care. By centering patients in trial design and therapy protocols, Clerkenwell Health aims to improve outcomes while supporting rigorous evaluation of novel psychedelic interventions.

Momentu supports employee mental health by offering a platform that assesses emotional needs and provides personalized digital content, therapy, and coaching sessions. This helps reduce absenteeism and boost team productivity.

Trek Health develops software that enables mental health providers to commence working with insurance networks. Its platform employs artificial intelligence to analyze market data, facilitating payer contract benchmarking and negotiation.

Cognigenics is a company focused on transforming mental health through cognitive neuroengineering, which involves the genetic engineering of cognitive traits that enhance mental well-being. By developing therapies aimed at traits such as mindfulness, relaxation, and mental acuity, Cognigenics seeks to improve human performance and address cognitive deficits in individuals experiencing mental health challenges, including stress, anxiety, and depression. The company's innovative approach positions it at the forefront of mental healthcare, leveraging advancements in genetics to create effective solutions for enhancing cognitive function and overall mental health.

Carbon Crusher specializes in providing innovative road maintenance services aimed at reducing carbon footprints for public and private road owners and contractors. The company employs proprietary technology to recycle existing road materials on-site, utilizing a plant-based binder as a sustainable alternative to traditional bitumen. This approach not only stabilizes the base layer of the road but also promotes the development of carbon-negative infrastructure. By identifying problem areas and offering comprehensive service and support, Carbon Crusher enhances the durability and circularity of road systems, contributing to long-term road security and environmental sustainability.

Founded in 2018, Wellset operates an online platform that connects users with wellness practitioners. It offers a wide range of services including mental health classes, stretching exercises, self-hypnosis, functional medicine, breathwork, EFT tapping, guided journaling, and meditation.

Homecoming is a provider of patient engagement tools specifically designed for psychedelic therapy. The company has developed a digital companion application that supports patients throughout their therapeutic process. This application promotes accountability and fosters long-term change by offering personalized guides, tasks, and daily check-ins. Additionally, it provides preparation and integration support within a single, user-friendly platform that includes relevant patient program content. This enables healthcare professionals to effectively guide their patients on their healing journeys, enhancing the therapeutic experience and outcomes.

Mindstate Design Labs is a biotechnology company developing psychedelic-inspired therapies for intractable mental health conditions. It maps the biological basis of psychedelic experiences to design targeted psychoactive effects for medically supervised settings, aiming to treat root causes of mental health disorders.

Breathwrk develops a mobile application offering science-backed guided breathing exercises. Users can manage mental wellness by reducing anxiety, improving sleep, enhancing focus, and boosting energy.

Progressive Therapeutics is a life sciences company focused on developing innovative psychoactive and psychedelic therapeutics aimed at addressing mental health challenges. The company has created a therapeutics platform designed to provide effective treatment solutions specifically tailored for women's mental health needs. By concentrating on this demographic, Progressive Therapeutics seeks to empower women to manage and overcome their mental health issues, ultimately promoting healthier lifestyles.

Wavepaths, established in 2018 and based in London, specializes in developing accessible technology for psychedelic therapy. The company creates personalized soundtracks using intelligent technologies and immersive media, aiming to facilitate inner exploration and emotional reconnection during drug-free therapeutic sessions. Their offerings span the fields of information technology, healthcare, and personal health.

Founded in 2020, Journey Colab is a San Francisco-based company dedicated to developing psychedelic therapies for mental health treatment. Their primary focus is on mescaline, aiming to strengthen communities by healing individuals.

Journey Clinical offers an online platform that supports independent psychotherapists in expanding their practices to include ketamine-assisted psychotherapy. The company facilitates prescription services, enabling mental health professionals to provide safe and effective psychedelic therapy to patients.

Formo is Europe's first cellular agriculture company developing animal-free dairy products. It uses precision fermentation to derive real, nature-identical milk proteins, offering sustainable and ethical alternatives for consumers.

Wild Earth is a technology-driven pet food company that develops plant-based, clean-protein diets for pets. It aims to provide healthier nutrition that is more humane and environmentally sustainable than conventional pet foods. Founded in 2017 and headquartered in Berkeley, California, Wild Earth emphasizes science-based formulations to meet pets' nutritional needs while reducing environmental impact.

Lief Therapeutics is a medical device company based in San Francisco, California, focused on enhancing at-home care for individuals dealing with post-traumatic stress disorder, depression, and anxiety. The company has developed a discreet bio-sensing patch that accurately measures heart rate and breath, allowing users to manage their natural stress response through vibratory biofeedback exercises. This wearable device helps users monitor their behaviors, emotions, and thoughts in real-time, fostering mindfulness and control throughout the day. Additionally, it supports clinicians by tracking patient progress, facilitating in-session training, and scheduling psychological assessments. Lief Therapeutics also offers the Lief Health Score application, which records thoughts, emotions, and sensations, enabling users to track daily progress and engage in tailored exercises. Founded in 2014, the company sells its products online, aiming to empower individuals in their mental health journeys.

Founded in Palo Alto, California in 2020 by Matthew Baggott and Luke Pustejovsky, Tactogen is a biopharmaceutical startup dedicated to developing empathogen medicines. Its mission is to create safer, more effective prescription drugs that promote mental wellness and emotional connection.

Bexson Biomedical is focused on developing an innovative subcutaneous delivery system for ketamine, aimed at treating chronic and acute pain disorders. The company’s lead product features a unique formulation of ketamine, which is administered through a minimally invasive, wearable infusion pump. This system addresses the limitations of existing ketamine preparations by helping to control overdosing risks and reducing the need for continuous monitoring. By enhancing the delivery method, Bexson Biomedical seeks to provide physicians with an effective tool for pain management.

Dendra Systems is an environmental technology company focused on restoring natural ecosystems globally. It develops tools and capabilities to power scalable ecosystem restoration, combining data analytics and automation to support restoration and reporting requirements for enterprises. The company addresses degraded land worldwide where restoration has lagged behind habitat destruction, offering an integrated approach that helps organizations plan, monitor, and execute restoration projects. By providing technology that enables data-driven decisions and automation, Dendra Systems aims to improve the efficiency and scale of restoration efforts, contributing to rebalancing human impact on the natural world.

Fathom Radiant was created on the premise of applying first-principles thinking to create technology capable of enabling artificial general intelligence for the benefit of all. The company does not believe that the beneficial advancement of AI is unavoidable, and Faathom believes that as a company offering a critical layer in the AI technology stack, we can make a difference in how securely advanced AI systems are built and deployed.

SCiFi Foods is a food technology company focused on developing a sustainable and ethical alternative to conventional meat through the production of cultivated meat. By combining lab-grown meat cells with plant-based ingredients, the company aims to create burgers that closely replicate the taste and sensory experience of traditional beef. SCiFi Foods has achieved significant milestones, including the successful growth of beef cells in suspension, which has the potential to dramatically reduce production costs. Co-founded by CEO Joshua March and CTO Kasia Gora, PhD, the company leverages advanced bioengineering techniques to provide a nutritious and animal-free meat experience. With a commitment to transforming the food landscape, SCiFi Foods has attracted substantial investment from prominent venture capital firms.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Cervest Limited is a London-based company that specializes in climate intelligence through its AI-powered machine learning platform. Established in 2015, Cervest focuses on translating complex Earth Science data to forecast risks and opportunities for sustainable growth. Its key product, EarthScan, empowers decision-makers across various sectors, including food and beverage, insurance, and government, to quantify and manage climate-related risks at an asset level. The platform provides open and independent tools that help users understand the potential impacts of climate events such as flooding, droughts, and extreme temperatures on their assets. As a Certified B Corporation, Cervest is committed to democratizing access to climate intelligence and promoting shared responsibility in safeguarding critical assets against climate change.

Beam Mobility Holdings Pte. Ltd. is a micro-mobility company that offers electric scooters for rent through a user-friendly mobile application. Established in 2018 and based in Singapore, Beam aims to enhance urban mobility by providing a network of shared e-scooters that can be easily accessed on a pay-per-use basis. The company promotes responsible parking by incentivizing users to return scooters to designated parking spots, thereby minimizing clutter on city streets. By leveraging Internet of Things technology, Beam contributes to improved last-mile connectivity, helps alleviate traffic congestion, and supports environmental sustainability efforts.

Heart Aerospace AB, established in 2018 with headquarters in Gothenburg, Sweden, and operations in Palo Alto, California, specializes in developing electric regional airliners certified for passenger flight. The company's mission is to facilitate swift, affordable, and sustainable travel for regional journeys worldwide. Their flagship aircraft, the ES-19, is a nineteen-passenger electric airliner designed with an operating range of 400 km, aiming to reduce fuel and maintenance costs compared to traditional aircraft while emitting zero operational emissions. Heart Aerospace targets commercial operation certification for the ES-19 by 2026.

Golden is a developer of a self-constructing knowledge platform designed to aggregate information from various public and private sources, creating a comprehensive repository. The company's platform employs natural language processing to facilitate structured representation of entities and topics, making detailed and canonical information easily searchable and accessible. By leveraging both human effort and machine intelligence, Golden enhances the process of knowledge gathering and communication. Its features include powerful search capabilities, fine-grain alerts to track changes, and semi-automatic research assistance, all aimed at helping organizations stay informed and leverage the latest industry trends. This approach improves collaboration among researchers and academics while enhancing operational efficiency.

Shiok Meats is a Singapore-based company founded in 2018 that specializes in cellular aquaculture, focusing on the production of cell-based meats and seafood. By harvesting from cells rather than animals, the company aims to provide clean and healthy alternatives to traditional meat products. Its primary offerings include lab-cultured shrimp and other crustacean meats, which are designed to be animal-friendly, health-conscious, and environmentally sustainable. Shiok Meats strives to deliver products that retain the same taste, texture, and nutritional value as conventional seafood, thereby catering to consumers seeking healthier and more ethical food options.

ZeroDown is a real estate startup established in 2018 that aims to provide an affordable solution for homeownership. The company offers an innovative alternative to traditional rent-or-own options, allowing individuals to enjoy the benefits of owning a home while retaining the flexibility associated with renting. Its platform features a comprehensive home search website and delivers various real estate services, including brokerage, mortgage origination, and rent-to-own arrangements. This approach enables users to determine the appropriate financing for their home purchases, thereby freeing up capital for additional investments. Founded by Abhijeet Dwivedi, Hari Viswanathan, and Laks Srini, who previously held key positions at Zenefits, ZeroDown leverages their expertise to enhance the home-buying experience.

Good Money is a digital banking platform offering traditional banking services while emphasizing customer ownership and social impact. The company aims to create a structure in which customers share in ownership benefits and profits are partly allocated to protecting the environment and advancing social justice. It features a rewards debit card that enables customers to earn stock rewards on purchases and to grow the value of their shares, including through referrals, tying everyday banking to environmental stewardship and community outcomes.

Wright Electric Inc. is a manufacturer of commercial electric airplanes, focusing on reducing costs and emissions in the aviation industry. Founded in 2016 and headquartered in Los Angeles, California, the company utilizes unique propulsion technology to create aircraft that eliminate emissions without relying on offsets. This innovation aims to make zero-emissions flight as economically viable as traditional fossil-fueled aviation, marking a significant step towards the electrification of the aerospace sector and fostering a sustainable future for air travel.

Calm is a San Francisco-based company established in 2012, specializing in digital wellness products aimed at enhancing mental fitness and alleviating common mental health issues like anxiety, depression, insomnia, and stress. The company's flagship product is its meditation and relaxation app, which offers original audio content, stories, and programs to help users manage stress and improve overall well-being. Calm has been recognized for its impact, being named Apple's 2017 iPhone App of the Year and Google Play's Editors' Choice in 2018.

Pelago specializes in virtual substance use management, empowering members to overcome addiction, primarily tobacco, alcohol, or opioids. It offers cognitive behavioral therapy (CBT) and medication-assisted treatment (MAT) programs, delivered via an accessible platform that integrates with health plans and wellness platforms.