Lionheart Ventures

Piramidal is a technology company specializing in artificial intelligence software for neurological health. It converts brain activity data into user-friendly health information, aiding in the diagnosis of various neurological diseases. The company's AI platform aims to enhance neurological diagnosis, treatment, and monitoring, providing swift and accurate patient assessments.

Psylo is a drug development company that specializes in next-generation psychedelics aimed at treating mental illness. The company focuses on creating novel therapeutic solutions for psychiatric and neurological disorders, with an emphasis on non-hallucinogenic and rapid-acting agents. Psylo's mission is to develop improved medications that can serve as effective alternatives to traditional selective serotonin reuptake inhibitors (SSRIs), thereby enhancing treatment options for mood disorders, addiction, and certain neurological diseases. By leveraging psychedelic molecules as the foundation for its innovative therapies, Psylo seeks to make significant advancements in mental health treatment.

Clerkenwell Health is a mental health company providing clinical research support services and psychedelic-assisted therapies. It operates as a psychedelic-specialist contract research organization focused on psychiatry and central nervous system conditions, delivering independent CRO services to advance the adoption of psychedelic treatments in Europe. The company runs a healthcare clinic offering preparation, treatment sessions, and follow-up by experienced psychotherapists, and it collaborates to produce robust, clinically validated data sets that demonstrate the efficacy of psilocybin-assisted therapy relative to existing standards of care. By centering patients in trial design and therapy protocols, Clerkenwell Health aims to improve outcomes while supporting rigorous evaluation of novel psychedelic interventions.

Momentu operates a digital platform focused on corporate mental health, aiming to address employee wellbeing challenges. It offers emotional assessments to understand individual needs, followed by personalized support via digital resources, therapy sessions, and coaching. By providing such services, Momentu helps businesses reduce absenteeism and enhance team productivity.

Trek Health is a healthcare technology company that develops foundational software designed to assist mental health providers in integrating with insurance networks. Its platform offers financial insights through advanced revenue cycle management (RCM) and payer transparency solutions. By monitoring patient coverage and facilitating instant reimbursement for claims, Trek Health streamlines the claims process and other administrative tasks. This enables healthcare providers to manage all operational workflows efficiently within a single online platform. The company offers various modes of contact, including mail, phone, and physical address, to support its clients effectively.

Cognigenics is a company focused on transforming mental health through cognitive neuroengineering, which involves the genetic engineering of cognitive traits that enhance mental well-being. By developing therapies aimed at traits such as mindfulness, relaxation, and mental acuity, Cognigenics seeks to improve human performance and address cognitive deficits in individuals experiencing mental health challenges, including stress, anxiety, and depression. The company's innovative approach positions it at the forefront of mental healthcare, leveraging advancements in genetics to create effective solutions for enhancing cognitive function and overall mental health.

Carbon Crusher specializes in providing innovative road maintenance services aimed at reducing carbon footprints for public and private road owners and contractors. The company employs proprietary technology to recycle existing road materials on-site, utilizing a plant-based binder as a sustainable alternative to traditional bitumen. This approach not only stabilizes the base layer of the road but also promotes the development of carbon-negative infrastructure. By identifying problem areas and offering comprehensive service and support, Carbon Crusher enhances the durability and circularity of road systems, contributing to long-term road security and environmental sustainability.

Founded in 2018, Wellset operates an online platform that connects users with wellness practitioners. It offers a wide range of services including mental health classes, stretching exercises, self-hypnosis, functional medicine, breathwork, EFT tapping, guided journaling, and meditation.

Homecoming is a provider of patient engagement tools specifically designed for psychedelic therapy. The company has developed a digital companion application that supports patients throughout their therapeutic process. This application promotes accountability and fosters long-term change by offering personalized guides, tasks, and daily check-ins. Additionally, it provides preparation and integration support within a single, user-friendly platform that includes relevant patient program content. This enables healthcare professionals to effectively guide their patients on their healing journeys, enhancing the therapeutic experience and outcomes.

Mindstate Design Labs is a clinical-stage biotechnology company focused on developing innovative psychedelic-inspired therapeutics aimed at addressing intractable mental health conditions. By mapping the biological underpinnings of various psychedelic experiences, the company designs psychoactive effects intended for use in medically supervised environments. Their platform leverages a combination of natural history and computational methods to predict the acute effects of serotonergic agonists in humans. This allows healthcare institutions to effectively alter states of consciousness, facilitating the treatment of mental health disorders at their root.

Breathwrk, Inc. is a company based in Venice, California, that specializes in developing a mobile application focused on guided breathing exercises. Founded in 2019, the Breathwrk app offers science-backed techniques designed to enhance mental and physical wellness. Users can access a variety of easy-to-follow exercises aimed at alleviating anxiety, promoting better sleep, increasing energy levels, and improving mood. The application also addresses issues related to athletic performance, stress management, and mental clarity, making it a versatile tool for individuals seeking to improve their overall well-being. Through its innovative approach to breath work, Breathwrk empowers users to take control of their mental and physical health.

Progressive Therapeutics is a life sciences company focused on developing innovative psychoactive and psychedelic therapeutics aimed at addressing mental health challenges. The company has created a therapeutics platform designed to provide effective treatment solutions specifically tailored for women's mental health needs. By concentrating on this demographic, Progressive Therapeutics seeks to empower women to manage and overcome their mental health issues, ultimately promoting healthier lifestyles.

Wavepaths, established in 2018 and based in London, specializes in developing accessible technology for psychedelic therapy. The company creates personalized soundtracks using intelligent technologies and immersive media, aiming to facilitate inner exploration and emotional reconnection during drug-free therapeutic sessions. Their offerings span the fields of information technology, healthcare, and personal health.

Journey Colab pursuing FDA approval of psychedelic therapies to heal individual mental health and strengthen communities. Their first compound in development is mescaline. It was founded in 2020 and is based in San Francisco, California.

Journey Clinical offers an online platform that supports independent psychotherapists in expanding their practices to include ketamine-assisted psychotherapy. The company facilitates prescription services, enabling mental health professionals to provide safe and effective psychedelic therapy to patients.

Formo is Europe's pioneering cellular agriculture company specializing in the development of animal-free dairy products. By utilizing precision fermentation, Formo harvests real, nature-identical milk proteins that allow for the creation of clean and sustainable dairy alternatives. The company aims to provide vegan food options that retain the taste and nutritional benefits of traditional dairy while promoting a more sustainable and equitable food system. Through innovative biotechnology, Formo transforms nutrients into high-quality milk proteins, catering to the growing demand for healthier and environmentally friendly dairy products.

Wild Earth is a technology-driven pet food company that develops plant-based, clean-protein diets for pets. It aims to provide healthier nutrition that is more humane and environmentally sustainable than conventional pet foods. Founded in 2017 and headquartered in Berkeley, California, Wild Earth emphasizes science-based formulations to meet pets' nutritional needs while reducing environmental impact.

Lief Therapeutics is a medical device company based in San Francisco, California, focused on enhancing at-home care for individuals dealing with post-traumatic stress disorder, depression, and anxiety. The company has developed a discreet bio-sensing patch that accurately measures heart rate and breath, allowing users to manage their natural stress response through vibratory biofeedback exercises. This wearable device helps users monitor their behaviors, emotions, and thoughts in real-time, fostering mindfulness and control throughout the day. Additionally, it supports clinicians by tracking patient progress, facilitating in-session training, and scheduling psychological assessments. Lief Therapeutics also offers the Lief Health Score application, which records thoughts, emotions, and sensations, enabling users to track daily progress and engage in tailored exercises. Founded in 2014, the company sells its products online, aiming to empower individuals in their mental health journeys.

Founded in Palo Alto, California in 2020 by Matthew Baggott and Luke Pustejovsky, Tactogen is a biopharmaceutical startup dedicated to developing empathogen medicines. Its mission is to create safer, more effective prescription drugs that promote mental wellness and emotional connection.

Bexson Biomedical is focused on developing an innovative subcutaneous delivery system for ketamine, aimed at treating chronic and acute pain disorders. The company’s lead product features a unique formulation of ketamine, which is administered through a minimally invasive, wearable infusion pump. This system addresses the limitations of existing ketamine preparations by helping to control overdosing risks and reducing the need for continuous monitoring. By enhancing the delivery method, Bexson Biomedical seeks to provide physicians with an effective tool for pain management.

Dendra Systems is an environmental technology company focused on restoring natural ecosystems worldwide. The company aims to empower humanity to achieve a balance in the natural world by providing innovative tools for scalable ecosystem restoration. Its technology addresses the challenges posed by degraded land, which has resulted from years of ecological imbalance. By offering an integrated approach that combines data analytics and automation services, Dendra Systems enables enterprises to effectively meet their ecosystem restoration and reporting needs.

Fathom Radiant was created on the premise of applying first-principles thinking to create technology capable of enabling artificial general intelligence for the benefit of all. The company does not believe that the beneficial advancement of AI is unavoidable, and Faathom believes that as a company offering a critical layer in the AI technology stack, we can make a difference in how securely advanced AI systems are built and deployed.

SCiFi Foods is a food technology company focused on developing a sustainable and ethical alternative to conventional meat through the production of cultivated meat. By combining lab-grown meat cells with plant-based ingredients, the company aims to create burgers that closely replicate the taste and sensory experience of traditional beef. SCiFi Foods has achieved significant milestones, including the successful growth of beef cells in suspension, which has the potential to dramatically reduce production costs. Co-founded by CEO Joshua March and CTO Kasia Gora, PhD, the company leverages advanced bioengineering techniques to provide a nutritious and animal-free meat experience. With a commitment to transforming the food landscape, SCiFi Foods has attracted substantial investment from prominent venture capital firms.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Cervest Limited is a London-based company that specializes in climate intelligence through its AI-powered machine learning platform. Established in 2015, Cervest focuses on translating complex Earth Science data to forecast risks and opportunities for sustainable growth. Its key product, EarthScan, empowers decision-makers across various sectors, including food and beverage, insurance, and government, to quantify and manage climate-related risks at an asset level. The platform provides open and independent tools that help users understand the potential impacts of climate events such as flooding, droughts, and extreme temperatures on their assets. As a Certified B Corporation, Cervest is committed to democratizing access to climate intelligence and promoting shared responsibility in safeguarding critical assets against climate change.

Beam Mobility Holdings Pte. Ltd. is a micro-mobility company that offers electric scooters for rent through a user-friendly mobile application. Established in 2018 and based in Singapore, Beam aims to enhance urban mobility by providing a network of shared e-scooters that can be easily accessed on a pay-per-use basis. The company promotes responsible parking by incentivizing users to return scooters to designated parking spots, thereby minimizing clutter on city streets. By leveraging Internet of Things technology, Beam contributes to improved last-mile connectivity, helps alleviate traffic congestion, and supports environmental sustainability efforts.

Heart Aerospace AB, established in 2018 with headquarters in Gothenburg, Sweden, and operations in Palo Alto, California, specializes in developing electric regional airliners certified for passenger flight. The company's mission is to facilitate swift, affordable, and sustainable travel for regional journeys worldwide. Their flagship aircraft, the ES-19, is a nineteen-passenger electric airliner designed with an operating range of 400 km, aiming to reduce fuel and maintenance costs compared to traditional aircraft while emitting zero operational emissions. Heart Aerospace targets commercial operation certification for the ES-19 by 2026.

Golden is a developer of a self-constructing knowledge platform designed to aggregate information from various public and private sources, creating a comprehensive repository. The company's platform employs natural language processing to facilitate structured representation of entities and topics, making detailed and canonical information easily searchable and accessible. By leveraging both human effort and machine intelligence, Golden enhances the process of knowledge gathering and communication. Its features include powerful search capabilities, fine-grain alerts to track changes, and semi-automatic research assistance, all aimed at helping organizations stay informed and leverage the latest industry trends. This approach improves collaboration among researchers and academics while enhancing operational efficiency.

Shiok Meats is a Singapore-based company founded in 2018 that specializes in cellular aquaculture, focusing on the production of cell-based meats and seafood. By harvesting from cells rather than animals, the company aims to provide clean and healthy alternatives to traditional meat products. Its primary offerings include lab-cultured shrimp and other crustacean meats, which are designed to be animal-friendly, health-conscious, and environmentally sustainable. Shiok Meats strives to deliver products that retain the same taste, texture, and nutritional value as conventional seafood, thereby catering to consumers seeking healthier and more ethical food options.

ZeroDown is a real estate startup established in 2018 that aims to provide an affordable solution for homeownership. The company offers an innovative alternative to traditional rent-or-own options, allowing individuals to enjoy the benefits of owning a home while retaining the flexibility associated with renting. Its platform features a comprehensive home search website and delivers various real estate services, including brokerage, mortgage origination, and rent-to-own arrangements. This approach enables users to determine the appropriate financing for their home purchases, thereby freeing up capital for additional investments. Founded by Abhijeet Dwivedi, Hari Viswanathan, and Laks Srini, who previously held key positions at Zenefits, ZeroDown leverages their expertise to enhance the home-buying experience.

Good Money is a digital banking platform focused on providing traditional banking services while prioritizing customer ownership and social responsibility. The company operates with a unique structure that allows customers to benefit from the ownership of the bank, distributing ownership rewards. It offers a rewards debit card that enables customers to earn stock rewards on their purchases. Additionally, Good Money commits to investing 50% of its profits in initiatives aimed at environmental protection and social justice. Through its innovative approach, the platform seeks to empower customers not only financially but also socially, enabling them to grow the value of their shares by referring new users.

Wright Electric Inc. is a manufacturer of commercial electric airplanes, focusing on reducing costs and emissions in the aviation industry. Founded in 2016 and headquartered in Los Angeles, California, the company utilizes unique propulsion technology to create aircraft that eliminate emissions without relying on offsets. This innovation aims to make zero-emissions flight as economically viable as traditional fossil-fueled aviation, marking a significant step towards the electrification of the aerospace sector and fostering a sustainable future for air travel.

Calm is a San Francisco-based company established in 2012, specializing in digital wellness products aimed at enhancing mental fitness and alleviating common mental health issues like anxiety, depression, insomnia, and stress. The company's flagship product is its meditation and relaxation app, which offers original audio content, stories, and programs to help users manage stress and improve overall well-being. Calm has been recognized for its impact, being named Apple's 2017 iPhone App of the Year and Google Play's Editors' Choice in 2018.

Pelago specializes in virtual substance use management, empowering members to overcome addiction, primarily tobacco, alcohol, or opioids. It offers cognitive behavioral therapy (CBT) and medication-assisted treatment (MAT) programs, delivered via an accessible platform that integrates with health plans and wellness platforms.