Lionheart Ventures

Piramidal offers artificial intelligence software that transforms brain activity into easy-to-understand health data to help diagnose neurological diseases.

Psylo is a drug development company that specializes in next-generation psychedelics aimed at treating mental illness. The company focuses on creating novel therapeutics for psychiatric and neurological disorders, emphasizing non-hallucinogenic and rapid-acting agents. By leveraging psychedelic molecules, Psylo seeks to develop improved medications that provide effective alternatives to existing selective serotonin reuptake inhibitors (SSRIs). Its mission is to enhance treatment options for mood disorders, addiction, and certain neurological conditions, thereby broadening the scope of mental health care.

Clerkenwell Health is a mental health company that specializes in providing clinical research support services and psychedelic-assisted therapies, particularly focusing on psilocybin. The company offers a structured course of multi-session therapy, which includes preparation, treatment sessions, and follow-up care conducted by experienced psychotherapists. By employing independent, psychedelic-specialist contract research organization (CRO) services, Clerkenwell Health aims to facilitate the adoption of these innovative treatments throughout Europe. The organization is committed to centering patient needs in clinical trial design and ensuring the delivery of high-quality therapy protocols, ultimately generating robust and clinically validated data to demonstrate the effectiveness of psilocybin-assisted therapy compared to traditional care methods.

Momentu is a corporate mental health platform designed to address the mental health challenges faced by employees. The company offers emotional assessments to help workers identify their needs and provides personalized support through digital content, therapy, and coaching sessions. By focusing on mental health, Momentu aims to reduce absenteeism and enhance productivity within organizations, ultimately fostering a healthier work environment.

Trek Health develops software designed to assist mental health providers in integrating with insurance networks. The company offers a healthcare platform that provides financial insights through advanced revenue cycle management and payer transparency solutions. By monitoring patient coverage and facilitating instant reimbursement for claims, Trek Health streamlines the management of claims and administrative tasks. This enables healthcare providers to efficiently manage their operational workflows through a single online platform, enhancing their ability to deliver care while minimizing administrative burdens. Communication with the company is facilitated through mail, phone, or physical address.

Cognigenics is dedicated to transforming mental health through cognitive neuroengineering, a specialized field focused on the genetic engineering of beneficial cognitive traits. The company aims to enhance human performance by developing therapies that promote mindfulness, relaxation, and mental acuity. These innovations are particularly targeted at individuals experiencing cognitive deficits due to mental health conditions such as stress, anxiety, and depression. By leveraging advancements in genetic science, Cognigenics seeks to provide effective solutions that improve overall mental well-being and address the challenges posed by various mental health issues.

Carbon Crusher provides carbon crushing services aimed at public and private road owners and contractors. The company focuses on reducing the carbon footprint associated with road maintenance by utilizing proprietary crushers that recycle existing road materials on-site. Instead of traditional bitumen, Carbon Crusher employs a plant-based binder to stabilize the road's base layer, promoting the creation of carbon-negative roads. This innovative approach not only addresses immediate road repair needs but also enhances the durability and sustainability of infrastructure, allowing clients to achieve long-term road security with comprehensive service and support.

Wellset Inc., founded in 2018 and located in Los Angeles, California, operates a comprehensive online platform designed to connect customers with wellness practitioners across various disciplines, including acupuncture, chiropractic care, massage therapy, nutrition, and health coaching. The platform not only facilitates the discovery and booking of these providers but also features a digital mental health studio that offers daily live classes and an extensive on-demand library. Users can access a wide range of holistic practices such as stretching, self-hypnosis, breathwork, and guided journaling. Wellset aims to support individuals in addressing their wellness needs by providing tailored access to qualified professionals and a variety of wellness resources.

Homecoming is a provider of patient engagement tools tailored for psychedelic therapy. The company has developed a digital companion application that supports patients throughout their healing process. This application promotes accountability and long-term change by offering personalized guides, tasks, and daily check-ins, all within a user-friendly platform. It also facilitates preparation and integration support, enabling healthcare professionals to effectively guide their patients. Homecoming's focus on enhancing the therapeutic experience aims to improve outcomes for individuals undergoing psychedelic therapy.

Mindstate Design Labs is a clinical-stage biotechnology company focused on developing innovative psychedelic-inspired therapeutics aimed at addressing intractable mental health and behavioral conditions. The company employs a unique platform that combines natural history and computational methods to map the biological basis of various psychedelic experiences. This mapping allows Mindstate Design Labs to design psychoactive effects intended for use in medically supervised environments, targeting the root causes of mental health disorders. By utilizing serotonergic agonists, the company seeks to enable healthcare institutions to effectively alter states of consciousness for therapeutic purposes.

Breathwrk, Inc. is a company that develops a mobile application focused on guided breathing exercises aimed at enhancing mental and physical wellness. Founded in 2019 and based in Venice, California, the Breathwrk app provides users with science-backed techniques designed to alleviate anxiety, improve sleep quality, increase energy levels, and enhance athletic performance. The application offers easy-to-follow breathing exercises that help manage stress, reduce blood pressure, and improve overall mood and focus. By promoting breath work, Breathwrk seeks to address a variety of issues, including sleep disorders, low energy, and racing thoughts, making it a valuable resource for users looking to improve their well-being.

Progressive Therapeutics is a life sciences company focused on developing innovative psychoactive and psychedelic therapeutics aimed at addressing mental health challenges. The company has created a therapeutics platform designed to provide effective treatment solutions tailored to the mental health needs of women. Through its research and development efforts, Progressive Therapeutics aims to empower women to overcome mental health issues and improve their overall well-being.

Wavepaths is a London-based company established in 2018 that focuses on creating innovative tools for psychedelic therapy aimed at facilitating inner exploration and personal transformation. The company develops a unique application that auto-generates individualized soundtracks for drug-free therapy sessions, integrating immersive media with advancements in intelligent technology and psychedelic science. By combining these elements, Wavepaths offers mobile tools and physical environments designed to help users reconnect with their inner resources, fostering meaningful introspection and emotional reconnection. The company's work lies at the intersection of information technology, healthcare, and personal health, emphasizing accessibility and personal growth through therapeutic experiences.

Journey Colab pursuing FDA approval of psychedelic therapies to heal individual mental health and strengthen communities. Their first compound in development is mescaline. It was founded in 2020 and is based in San Francisco, California.

Journey Clinical is a platform that provides services to member psychotherapy practices that are independently owned and operated, and in no way owns, directs, or controls the mental healthcare clinicians providing care.

Formo is a pioneering cellular agriculture company based in Europe that specializes in creating animal-free dairy products. By utilizing precision fermentation, Formo develops real, nature-identical milk proteins, allowing for the production of clean dairy alternatives. The company aims to provide sustainable and healthy options for consumers, particularly those seeking vegan food products. Through innovative biotechnology, Formo transforms nutrients into dairy proteins, contributing to a more equitable and environmentally friendly approach to dairy consumption.

Wild Earth is a technology startup based in Berkeley, California, founded in 2017. The company specializes in developing sustainable protein pet foods for dogs and cats, focusing on creating healthier options that are also environmentally friendly and humane compared to traditional pet food products. By leveraging scientific advancements, Wild Earth aims to ensure that pets receive all their nutritional needs while promoting a more sustainable approach to pet food production.

Lief Therapeutics is a medical device company focused on improving at-home care for individuals suffering from post-traumatic stress disorder, depression, and anxiety. The company has developed a discreet biosensing patch that measures heart rate and breathing patterns with medical accuracy. This wearable device, known as Lief, helps users manage their stress responses through biofeedback exercises, allowing them to monitor their emotions and behaviors in real-time. Additionally, the device provides clinicians with insights into patient progress, enabling in-session training and tracking of psychological assessments. Lief Therapeutics also offers the Lief Health Score application, which records thoughts, emotions, and sensations, facilitating the tracking of daily progress and personalized practice exercises. Founded in 2014 and based in San Francisco, California, the company sells its products online.

Tactogen is a biopharma startup based in Palo Alto, California, founded in 2020 by neuroscientist Matthew Baggott and entrepreneur Luke Pustejovsky. The company focuses on developing empathogen medicines, which are designed to promote mental wellness and facilitate emotional connection among individuals. Tactogen's innovative approach centers on creating safer and more effective pharmaceuticals, including novel molecules and drug discovery methods aimed at producing unique emotional states that balance openness and motivation. This research-driven initiative seeks to enhance the efficacy of psychotherapy and other psychological treatments while ensuring that empathogens can be prescribed safely for take-home use.

Bexson Biomedical is focused on creating an innovative formulation of ketamine specifically designed for the treatment of chronic and acute pain disorders. The company is developing a subcutaneous ketamine delivery system that aims to overcome the limitations of existing ketamine preparations, particularly in terms of controlling overdosing and minimizing the need for patient monitoring. Their lead product features a unique formulation of ketamine that is administered through a minimally invasive, wearable, subcutaneous infusion pump. This approach enables healthcare providers to more effectively manage pain in patients, enhancing treatment outcomes while addressing safety concerns associated with traditional ketamine therapies.

Dendra Systems is an environmental technology company focused on restoring natural ecosystems worldwide. The company's mission is to create tools that facilitate scalable ecosystem restoration, addressing issues caused by the degradation of land resulting from years of imbalance between ecosystem destruction and restoration efforts. Dendra offers an integrated approach that combines data analytics and automation services, enabling enterprises to meet their ecosystem restoration and reporting requirements effectively. Through its innovative technology, Dendra aims to empower humanity in the effort to restore and maintain the balance of the natural world.

Fathom Radiant was created on the premise of applying first-principles thinking to create technology capable of enabling artificial general intelligence for the benefit of all. The company does not believe that the beneficial advancement of AI is unavoidable, and Faathom believes that as a company offering a critical layer in the AI technology stack, we can make a difference in how securely advanced AI systems are built and deployed.

SCiFi Foods is a food technology company focused on producing cultivated meat that combines lab-grown beef cells with plant-based ingredients to create burgers that closely replicate the taste of traditional beef. The company aims to provide a sustainable and ethical alternative to conventional meat by utilizing bioengineering techniques to grow meat cells without relying on animal farming. SCiFi Foods has achieved significant advancements, including the successful growth of beef cells in suspension, which has the potential to drastically reduce production costs. Founded by CEO Joshua March and CTO Kasia Gora, PhD, the company has attracted $29 million in funding from prominent investors, positioning it for future growth in the alternative protein market.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Cervest Limited is a London-based company that has developed an AI-powered climate intelligence platform designed to assess and forecast risks and opportunities related to climate change on an asset level. Founded in 2015, Cervest's platform, including its EarthScan product, translates complex Earth Science data into actionable insights for various sectors, including food and beverage, insurance, and government entities. The platform empowers decision-makers to understand how climate events such as flooding, droughts, and extreme temperatures can affect their assets. Cervest operates with a mission to democratize access to climate intelligence and is recognized as a Certified B Corporation. The company is supported by investors committed to its mission, enabling it to provide open, independent tools for effective climate risk management.

Beam Mobility Holdings Pte. Ltd. is a micro-mobility company that offers electric scooters for rent through a user-friendly mobile application. Established in 2018 and based in Singapore, Beam aims to enhance urban mobility by providing a network of shared e-scooters that can be easily accessed on a pay-per-use basis. The company promotes responsible parking by incentivizing users to return scooters to designated parking spots, thereby minimizing clutter on city streets. By leveraging Internet of Things technology, Beam contributes to improved last-mile connectivity, helps alleviate traffic congestion, and supports environmental sustainability efforts.

Heart Aerospace AB, founded in 2018 and headquartered in Gothenburg, Sweden, with an additional location in Palo Alto, California, focuses on developing an electric regional airliner aimed at enhancing sustainable transportation for regional travel. The company's flagship aircraft, the ES-19, is designed to accommodate nineteen passengers and boasts an operational range of 400 kilometers. Heart Aerospace seeks to significantly reduce fuel and maintenance costs compared to traditional aircraft while achieving zero operational emissions. The innovative design allows for a low infrastructural footprint, facilitating the use of small airports located near city centers. Heart's objective is to secure certification for the ES-19 for commercial operations by 2026, aligning with its mission to provide affordable and environmentally friendly travel options across the globe.

Golden is a developer of a self-constructing knowledge platform designed to aggregate information from various public and private sources, creating a comprehensive repository. The platform offers structured representations of entities and topics, facilitating easy access to detailed information through a powerful search capability. By utilizing natural language processing, it interprets user queries, enabling researchers and academics to find relevant information efficiently. Additionally, Golden enhances collaboration and operational efficiency by providing semi-automatic research assistance that identifies knowledge gaps, allowing users to stay informed about the latest trends in their respective industries. Through the integration of human effort and machine intelligence, Golden simplifies the process of gathering and communicating knowledge.

Shiok Meats is a Singapore-based company founded in 2018 that specializes in cellular aquaculture, focusing on the production of cell-based meats and seafood. By harvesting from cells rather than animals, the company aims to provide clean and healthy alternatives to traditional meat products. Its primary offerings include lab-cultured shrimp and other crustacean meats, which are designed to be animal-friendly, health-conscious, and environmentally sustainable. Shiok Meats strives to deliver products that retain the same taste, texture, and nutritional value as conventional seafood, thereby catering to consumers seeking healthier and more ethical food options.

ZeroDown is a real estate startup established in 2018 that aims to provide an affordable solution for homeownership. The company offers an alternative to traditional renting and home buying, allowing individuals to enjoy the benefits of homeownership while maintaining the flexibility of renting. Its platform features a comprehensive home search website and a range of real estate services, including brokerage and mortgage origination. By facilitating a rent-to-own model, ZeroDown enables users to identify suitable financing options for their home purchases, thereby allowing them to allocate capital for other investments. The founders, Abhijeet Dwivedi, Hari Viswanathan, and Laks Srini, previously collaborated at Zenefits, where they gained extensive experience in operations and technology.

Good Money is a digital banking platform that prioritizes customer ownership and social responsibility. The platform offers traditional banking services alongside unique ownership benefits, allowing customers to share in the company's profits. Notably, Good Money commits to investing 50% of its profits in environmental protection and social justice initiatives. Its rewards debit card simplifies the process for customers to earn stock rewards on their purchases, while also encouraging them to refer new users, thereby increasing the value of their shares. Through this innovative approach, Good Money aims to align financial growth with positive social impact.

Wright Electric Inc. is a manufacturer of commercial electric airplanes, focusing on reducing costs and emissions in the aviation industry. Established in 2016 and headquartered in Los Angeles, California, the company utilizes innovative propulsion technology to produce aircraft that eliminate emissions without requiring offsets. This advancement not only promotes zero-emissions flight but also aims to make the operational costs comparable to those of traditional fossil-fueled fleets, thereby facilitating the transition to a more sustainable aerospace sector. Wright Electric is positioned to play a significant role in the electrification of aviation, marking a transformative shift in the industry.

Calm is a San Francisco-based company established in 2012, specializing in digital wellness products aimed at enhancing mental fitness and alleviating common mental health issues like anxiety, depression, insomnia, and stress. The company's flagship product is its meditation and relaxation app, which offers original audio content, stories, and programs to help users manage stress and improve overall well-being. Calm has been recognized for its impact, being named Apple's 2017 iPhone App of the Year and Google Play's Editors' Choice in 2018.

Pelago, formerly known as Quit Genius, is a leading virtual clinic focused on substance use management, particularly for tobacco, alcohol, and opioids. The company aims to transform support for substance use by offering education, management skills, and opportunities for positive change to individuals struggling with addiction. Pelago provides employers with a means to offer on-demand, personalized support for employees seeking healthier lifestyles. Its platform utilizes cognitive behavioral therapy (CBT) to address the psychological aspects of addiction, helping users identify triggers and access support through animated videos, interactive exercises, and audio sessions. This approach allows individuals to work at their own pace with the assistance of a personalized coach. Pelago's services seamlessly integrate with health plans, pharmacy benefit managers, and wellness platforms, and the company has successfully supported over 750,000 members in managing their substance use and improving their overall well-being.