Longevity Fund 2

Developer of veterinary pharmaceuticals designed to improve the health span and lifespan of dogs. The company's drugs delay the onset of age-related diseases like cancer, heart diseases and metabolic diseases, enabling dogs to live healthier, longer lives.

Edocate specializes in a simulation-based learning platform aimed at enhancing the education of medical professionals in chronic disease management. The platform offers virtual patient simulations, allowing users to engage in self-directed learning while developing practical skills. It is designed to accommodate the busy schedules of adult learners, integrating gamification elements and providing mobile and client access for ease of use. Additionally, Edocate facilitates ongoing training and assessment, enabling medical education providers to create and distribute their own case studies efficiently and cost-effectively. The focus on practice skills ultimately aims to improve the quality of care delivered by healthcare professionals.

Edocate specializes in a simulation-based learning platform aimed at enhancing the education of medical professionals in chronic disease management. The platform offers virtual patient simulations, allowing users to engage in self-directed learning while developing practical skills. It is designed to accommodate the busy schedules of adult learners, integrating gamification elements and providing mobile and client access for ease of use. Additionally, Edocate facilitates ongoing training and assessment, enabling medical education providers to create and distribute their own case studies efficiently and cost-effectively. The focus on practice skills ultimately aims to improve the quality of care delivered by healthcare professionals.

Rubedo Life Sciences, Inc. is a biopharmaceutical company based in Sunnyvale, California, focused on developing therapies for age-related diseases by targeting senescent cells. Incorporated in 2018, the company utilizes its ALEMBIC drug discovery platform to create a pipeline of therapeutic candidates that selectively eliminate senescent cells, as well as pro-inflammatory and pro-fibrotic cell populations resulting from cellular stress and damage. By promoting selective apoptosis in aged or pathological tissues, Rubedo aims to regenerate tissues, improve the function of healthy cells, and ultimately extend the health span of patients. The company is dedicated to addressing the challenges posed by age-related conditions through innovative therapeutic solutions.

Elevian, Inc. is a biotechnology company based in Menlo Park, California, founded in 2017. The company is focused on developing therapeutics aimed at restoring regenerative capacity to prevent and treat age-related diseases. Elevian's research centers on the Growth Differentiation Factor 11 (GDF11) protein and other circulating factors that stimulate regeneration in various tissues, including the brain, heart, pancreas, and muscles. The company's therapeutic candidates target the root causes of aging and aim to address conditions such as stroke recovery, Alzheimer's disease, coronary artery disease, and Type 2 diabetes. By identifying and regulating blood factors that influence aging, Elevian seeks to enable effective treatments that enhance the body’s natural repair and regeneration mechanisms.

Wellth develops and operates a mobile application to lower cost for payors and rewards for consumers. Its application engages consumers through providing targeted incentive plans, delivering reminders and information, and sharing cost savings that help them build healthy habits and foster disease management. It focuses on reducing the cost of the healthcare system by encouraging consumers to manage their diseases and to take preventative actions to stay healthy. Wellth is based in New York, New York.

Celevity is a seed-stage company that develops drugs to help dogs live longer, healthier lives. It sees aging as a disease that is able to be slowed and improved with medicines. It was spun out of Laura Deming’s The Longevity Fund. Celevity is headquartered in San Francisco, California.

Celevity is a seed-stage company that develops drugs to help dogs live longer, healthier lives. It sees aging as a disease that is able to be slowed and improved with medicines. It was spun out of Laura Deming’s The Longevity Fund. Celevity is headquartered in San Francisco, California.

Developer of veterinary pharmaceuticals designed to improve the health span and lifespan of dogs. The company's drugs delay the onset of age-related diseases like cancer, heart diseases and metabolic diseases, enabling dogs to live healthier, longer lives.

Epirium Bio, Inc. is a clinical-stage biopharmaceutical company based in San Diego, California, focused on developing therapeutics for cardiovascular diseases and metabolic syndrome. Established in 2008, the company has gained insights into mitochondrial biogenesis and function, leading to the discovery of a novel pharmacological approach for treating conditions associated with mitochondrial deficits. Epirium Bio has developed an intellectual property-protected platform of small molecules that represent a new class of therapeutics aimed at stimulating mitochondrial biogenesis and function. Their lead clinical candidate has demonstrated the ability to trigger mitochondrial biogenesis in early human studies and is being developed for various therapeutic areas, with an initial focus on rare diseases, neuromuscular, and neurodegenerative disorders. This innovative approach seeks to provide new treatment options for patients suffering from conditions such as muscular dystrophy.

Cardero Therapeutics is a start-up pharmaceutical company that is developing a novel class of therapeutics that induces the formation of new mitochondria (mitochondrial biogenesis) and enhances mitochondrial function in response to metabolic demand. Chronic depletion of mitochondria, the principal source of cellular ATP, has been directly linked to the progression of heart failure, sarcopenia, and neurodegeneration. Cardero Therapeutics is collaborating with numerous academic medical centers to advance novel drug candidates structurally based on a newly discovered human hormone that appears to fundamentally regulate mitochondrial density and function in all tissues. Cardero Therapeutics believes that enhancing myocyte bioenergetics will comprise an innovative therapeutic approach complementary to currently available cardiovascular drugs. The company’s clinical development focus is the lethal cardiomyopathy associated with orphan diseases characterized by loss of mitochondria in muscle and heart, resulting in heart failure that is poorly responsive to current medical interventions. Initial clinical trials are directed toward Duchenne muscular dystrophy and Friedreich’s ataxia.

Exo is a medical device startup handheld ultrasound platform and AI for imaging and therapeutic applications. The company is committed to delivering affordable and easy-to-use medical imaging to healthcare professionals around the world. By delivering easy-to-use, high-quality medical imaging. Exo empowers healthcare professionals to make critical, real-time decisions that improve patient outcomes. The Exo ultrasound platform combines advances in nano-materials, novel sensor technologies, advanced signal processing, and computation with the economies of scale of semiconductor manufacturing to dramatically reduce the cost of imaging. It also represents a giant leap in imaging and therapeutics technology one that will drive the development of high-performance products that are accessible, easy-to-use, and available at a price point never before possible.

Fauna Bio is developing new ways to treat human diseases, such as heart disease and neurodegenerative disease, by adopting mechanisms animals have developed for traits such as hibernation and deep-diving. Founded by three scientists who have intimate knowledge of the best science and resources from the field of non-model organisms, Fauna Bio leverages data from hundreds of species in order to help develop pre-clinical and early clinical testing for new therapeutics targeting human diseases.

Fauna Bio is developing new ways to treat human diseases, such as heart disease and neurodegenerative disease, by adopting mechanisms animals have developed for traits such as hibernation and deep-diving. Founded by three scientists who have intimate knowledge of the best science and resources from the field of non-model organisms, Fauna Bio leverages data from hundreds of species in order to help develop pre-clinical and early clinical testing for new therapeutics targeting human diseases.

Spring Discovery, Inc. operates a machine learning-based platform focused on accelerating the discovery of therapies for aging and age-related diseases. Based in Palo Alto, California, the company aims to target the biological processes of aging to uncover new treatments for a range of conditions, including cardiovascular and neurodegenerative diseases. By employing innovative computational methods, Spring Discovery enhances experimentation and supports pharmaceutical companies in improving medical treatments for aging-related ailments.

System1 Biosciences, Inc., founded in 2017 and headquartered in San Francisco, California, is a neurotherapeutics company focused on drug discovery for complex neurological and psychiatric diseases such as epilepsy, autism, and schizophrenia. By utilizing phenotypic screening, the company aims to overcome the limitations of existing discovery techniques in these challenging areas. System1 integrates cerebral organoid science, systems neuroscience, robotic automation, and advanced data analytics to achieve detailed characterizations of diseases, referred to as "deep phenotypes." These insights are employed to identify novel therapeutic targets and develop effective drug treatments.

Decibel Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing therapies aimed at protecting, repairing, and restoring hearing. The company focuses on a range of hearing disorders, including those related to cancer treatments, cystic fibrosis, noise exposure, age-related and genetic hearing loss, as well as tinnitus. It utilizes advanced techniques such as single-cell genomics, bioinformatics, and precision gene therapy technologies to enhance its understanding of inner ear pathology and to develop effective treatments. Decibel Therapeutics also offers expertise in drug delivery to the inner ear, imaging, and pharmacokinetic modeling, contributing to innovative therapeutic approaches for patients experiencing various forms of hearing loss. Founded in 2013 and based in Boston, Massachusetts, Decibel Therapeutics was previously known as Hearing, Inc. before rebranding in 2014.

Precision BioSciences, Inc. is a biotechnology company that specializes in genome editing, utilizing its proprietary ARCUS platform to develop therapeutic and food products. The Therapeutic segment focuses on creating allogeneic CAR T immunotherapies aimed at treating various cancers, including acute lymphoblastic leukemia and multiple myeloma, with several candidates currently in clinical trials. Notable product candidates include PBCAR0191, targeting CD19, and PBCAR269A, targeting BCMA. Additionally, the company is engaged in in vivo gene correction and has collaborations for developing treatments for chronic Hepatitis B. The Food segment aims to innovate in food and nutrition products. Founded in 2006 and headquartered in Durham, North Carolina, Precision BioSciences is committed to translating advanced genome editing technology into impactful medical and agricultural solutions.

Unity Biotechnology is a biotechnology company dedicated to the research and development of therapeutics aimed at extending human health span by addressing diseases associated with aging. The company specializes in clearing senescent cells through the creation of senolytic medicines, which target vulnerabilities specific to these cells while preserving normal ones. Its lead drug candidates include UBX0101, currently undergoing Phase II trials for musculoskeletal disorders and Phase Ib trials for moderate-to-severe knee osteoarthritis, and UBX1325, which is in Phase I trials for diabetic macular edema. Additionally, Unity is exploring treatments for various age-related conditions, including ophthalmologic, pulmonary, kidney, and liver diseases. Founded in 2009 and based in South San Francisco, California, Unity Biotechnology was formerly known as Forge, Inc. and rebranded in 2015.

Spring Discovery, Inc. operates a machine learning-based platform focused on accelerating the discovery of therapies for aging and age-related diseases. Based in Palo Alto, California, the company aims to target the biological processes of aging to uncover new treatments for a range of conditions, including cardiovascular and neurodegenerative diseases. By employing innovative computational methods, Spring Discovery enhances experimentation and supports pharmaceutical companies in improving medical treatments for aging-related ailments.

Precision BioSciences, Inc. is a biotechnology company that specializes in genome editing, utilizing its proprietary ARCUS platform to develop therapeutic and food products. The Therapeutic segment focuses on creating allogeneic CAR T immunotherapies aimed at treating various cancers, including acute lymphoblastic leukemia and multiple myeloma, with several candidates currently in clinical trials. Notable product candidates include PBCAR0191, targeting CD19, and PBCAR269A, targeting BCMA. Additionally, the company is engaged in in vivo gene correction and has collaborations for developing treatments for chronic Hepatitis B. The Food segment aims to innovate in food and nutrition products. Founded in 2006 and headquartered in Durham, North Carolina, Precision BioSciences is committed to translating advanced genome editing technology into impactful medical and agricultural solutions.

ALX Oncology Holdings Inc., a clinical-stage immuno-oncology company, focuses on developing therapies for patients fighting cancer. Its lead product candidate is ALX148, a CD47 blocking therapeutic used for the treatment of myelodysplastic syndromes and acute myeloid leukemia, as well as a range of solid tumor indications, including head and neck squamous cell and human epidermal growth factor receptor 2 positive gastric/gastroesophageal junction carcinoma. The company was founded in 2015 and is based in Burlingame, California.

Navitor Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing small molecule drugs that target mTORC1, a key regulator of cellular metabolism and renewal, to treat age-related diseases. Utilizing a proprietary platform, Navitor's therapies can selectively inhibit or activate mTORC1, which plays a crucial role in cellular processes. One of its notable products, NV-5138, is an orally bioavailable small molecule designed to activate mTORC1, particularly addressing its suppression in the brain associated with depression. Additionally, the company's N-Valog program focuses on selective inhibition of mTORC1 for chronic kidney disease, with implications for other age-related conditions. Founded in 2009 and headquartered in Cambridge, Massachusetts, Navitor Pharmaceuticals aims to unlock the therapeutic potential of the mTOR pathway by modulating nutrient-sensing proteins, thereby addressing various metabolic, neurodegenerative, autoimmune, and musculoskeletal diseases.