Main Sequence Ventures

Main Sequence Ventures focuses on investing in innovative founders who are developing the next generation of global industries through deep tech and frontier technologies. The firm is supported by the Australian National Science Agency, CSIRO, the Australian Federal Government, and various private investors. Its investment strategy is rooted in utilizing cutting-edge research from prominent Australian public research organizations, including CSIRO and the country's 41 universities, as well as other industry research agencies. This approach aims to foster advancements that can transform industries and drive economic growth.

William Bartee

Managing Partner

Alezeia Brown

Investor

Martin Duursma

Partner

Gabrielle Munzer

Partner

Mike Nicholls

Partner

Jun Qu

Investor

Michael Zimmerman

Partner

Past deals in Australia

Lumachain

Series A in 2022
Lumachain Pty Ltd is an Australian company that develops a software as a service (SaaS) platform for food supply chain management. Established in 2018 and based in Sydney, the platform provides transparency in global supply chains by enabling producers, enterprises, and consumers to trace the origin, location, and condition of individual items in real time, from farm to fork. This traceability encourages farmers and manufacturers to produce high-quality and ethically sourced products. Additionally, it helps enterprises minimize waste, enhance operational efficiency, and increase profitability. Consumers benefit by gaining certainty about the provenance, condition, and quality of their purchases, ensuring they are making informed choices regarding ethically and sustainably sourced food products.

Swoop Aero

Series B in 2022
Swoop Aero Pty Ltd, founded in 2017 and based in Melbourne, Australia, specializes in autonomous air transport as a service. The company is recognized for its expertise in building and operating air transportation networks, particularly in challenging environments. Swoop Aero distinguishes itself by gaining practical knowledge through real-world experience rather than theoretical study, positioning itself as a leader in the development of autonomous air transport solutions.

Emesent

Series A in 2022
Emesent Pty Ltd develops and markets hovermap system that collects data in underground areas. It offers complete inspection and mapping of underground assets such as mines, transport tunnels, and utility tunnels. The technology also works in areas that do not have global positioning system (GPS) access. The company was founded in 2018 and is based in Pullenvale, Australia.

Kasada

Series C in 2021
Kasada Pty Ltd is an Australian company specializing in cyber-security software solutions. Founded in 2014 and headquartered in Chippendale, Australia, with additional offices in the United States and the United Kingdom, Kasada develops a cloud-based product known as Kasada Polyform. This product focuses on automated bot detection and mitigation specifically designed for enterprise web applications. By addressing the economic challenges associated with the misuse of automation in applications and APIs, Kasada aims to enhance the security posture of organizations against malicious automated threats.

Q-CTRL

Series B in 2021
Q-CTRL Pty Ltd, established in 2017 and located in Pyrmont, Australia, specializes in developing software tools and firmware for the quantum computing sector. The company focuses on addressing critical challenges in quantum technology, such as noise and decoherence, which affect the performance of quantum devices. By leveraging its expertise in quantum control engineering, Q-CTRL provides intuitive software solutions designed to reduce errors in quantum bits, thereby stabilizing quantum hardware. Its offerings are particularly relevant in the NISQ (Noisy Intermediate-Scale Quantum) era, allowing users to better understand and manage the impacts of noise and errors in quantum systems. Through its innovative approach, Q-CTRL aims to make quantum technology more practical and accessible for various applications, including quantum sensing in defense.

Loam Bio

Series A in 2021
Loam Bio is a company focused on manufacturing microbial products designed to reduce atmospheric CO2 levels and enhance soil fertility. Founded in 2016 and based in Orange, Australia, the company is engaged in developing innovative technology that enables the inoculation of crops with symbiotic micro-organisms. This approach aims to improve agricultural sustainability by promoting healthier soils and more efficient carbon management.

QuintessenceLabs

Series B in 2021
The Global Leader in Quantum Security. The company has developed a suite of data security technology, products, and solutions to secure valuable digital information in-transit, at-rest or in-use. By centralizing the management and control of data-security policy and harnessing quantum science properties to strengthen data security solutions, its solutions maximize security, increase ROI from existing assets, and reduce data-security complexities. Customers include financial services companies such as Westpac Group, a leading Australian bank, Technology providers, such as NetDocuments, a cloud storage provider for the legal industry, and PKWare, federal customers such as the US State Department, and defence primes such as Boeing Corporation and Northrop Grumman.

Prospection

Series B in 2021
Prospection Pty Ltd is a Sydney-based company specializing in healthcare data analytics through its software as a service (SaaS) platforms. Founded in 2012, it leverages predictive analytics and machine learning to analyze real-world healthcare data, providing insights that enhance research and improve patient outcomes. The company's key offerings include PharmDash, which tracks patient medication usage and treatment progression, and PharmMap, a platform that integrates commercial and operational data using geospatial mapping. Prospection collaborates with government entities, pharmaceutical companies, and the medical community on over 70 therapy programs, with a focus on areas such as immuno-oncology, HIV, and hepatitis across Australia and the Asia Pacific region.

Quantum Brilliance

Seed Round in 2021
Quantum Brilliance builds and sells room temperature quantum computers powered by synthetic diamond, enabling applications in edge quantum computing and hybrid quantum-classical computing. We empower a future for ubiquitous quantum computing.

FluroSat

Series A in 2021
FluroSat Pty Ltd is an ag tech company based in Eveleigh, Australia, specializing in predictive crop health monitoring through advanced software solutions. Founded in 2016, FluroSat develops a decision support platform that utilizes multispectral and hyperspectral imagery collected from drones and satellites to assess crop health and identify specific stressors affecting yield. Their primary offerings include FluroSat, designed for cotton and grain growers, and ProductionWise, which enhances farm efficiency for commodity crops through features like paddock management, yield predictions, satellite monitoring, and localized weather forecasts. The company also provides consulting services that guide farmers on optimal application rates of fertilizers, fungicides, and irrigation, leading to potential savings on input costs and improved yields. FluroSat currently focuses on the Australian broadacre farming sector and aims to expand its reach internationally.

v2food

Series B in 2021
v2food is a plant-based meat startup that produces legume-based meat alternatives. The company v2 product is a delicious, nutritious alternative for anyone who loves the taste of meat but doesn’t want to get it from animals. It is a safe space to connect with like-minded people and create positive relationships with food that will help them feed the planet in a sustainable way. v2food was founded by Nick Hazell in 2019 and is based in Sydney, New South Wales, Australia.

MGA Thermal

Series A in 2021
MGA Thermal is a deep tech startup that provides a clean, economical, and scalable advanced thermal storage, enabling renewable energy to reliably provide 100% of base load power. Its core technology is a newly invented type of thermal storage material, Miscibility Gap Alloys (MGA). Modular blocks of MGA are stacked into insulated storage tanks, which can store energy for use in a vast range of applications, such as improving the electrical grid’s stability, residential and commercial space heating, industrial process and waste heat, and electric vehicles. MGA Thermal is based in Newcastle, Australia.

Gilmour Space

Series C in 2021
Gilmour Space Technologies Pty Ltd, founded in 2012 and headquartered in Pimpama, Australia, focuses on developing low-cost hybrid rockets specifically designed for the small satellite market. The company aims to provide reliable and affordable launch solutions for satellites weighing up to 400 kg. By utilizing proprietary 3D printed fuel, Gilmour Space enhances control over the combustion process, which allows for tailored performance during launches. The firm is positioned to serve research organizations and various clients seeking dedicated access to low Earth orbit, with commercial launches expected to commence from 2020.

Castlepoint Systems

Series A in 2021
Castlepoint Systems offers an AI-driven platform that streamlines the management of information and records within organizations. The software automatically discovers, classifies, and controls various types of data, including documents, emails, chat messages, databases, and webpages across a company's network. By utilizing artificial intelligence, Castlepoint helps enterprises identify rogue data and assess potential compliance risks in accordance with regulatory requirements. This comprehensive solution ensures that all organizational records are registered and managed effectively, applying appropriate lifecycle controls to maintain compliance and enhance data governance.

Baraja

Series B in 2021
Baraja is a 3D machine vision systems manufacturer. It has invented a new type of LiDAR called Spectrum-Scan which delivers the highest performance available to address the challenge of self-driving cars. Baraja is a rapidly growing start-up, with a revolutionary LiDAR for self-driving vehicles. The company is based in Sydney, Australia, with offices in China and the USA. It is quickly expanding worldwide, hiring through Europe and Asia, closely collaborating with car manufacturers to iterate and refine its vision of what LiDAR needs to be.

Kapiche

Seed Round in 2021
Kapiche Pty Ltd. is an Australian company that specializes in text analytics solutions for customer feedback. Founded in 2013 and based in Fortitude Valley, it offers an intelligence-powered analytics platform designed to help organizations centralize and understand feedback data from various sources, including surveys, net promoter scores, and product reviews. The platform enables clients to quickly gain deep, actionable insights from large volumes of feedback, identifying key themes, customer sentiments, and their impacts on relevant business metrics. By eliminating the need for manual coding or extensive reading of comments, Kapiche streamlines the process of deriving meaningful insights from customer and employee feedback, thus enhancing the understanding of customer experience for businesses.

Coviu

Venture Round in 2020
Coviu Global Pty Ltd provides telehealth tool to practitioners to help deliver video healthcare consultations to patients. It also offers practice management systems for patient record management. Its tool provides facilities, such as waiting area, customized clinics, dashboard, clinical governance, and white labelling. The company is incorporated in 2015 and is based in Sydney, Australia.

Morse Micro

Series A in 2020
Morse Micro PTY. LTD. is an Australian company specializing in the design and development of wireless chip technology, particularly focused on Wi-Fi solutions for the Internet of Things (IoT). Founded in 2016 and headquartered in Eveleigh, Australia, the company offers Wi-Fi HaLow, a low-power wireless technology that enables connections up to one kilometer, making it suitable for a variety of applications including home automation, industrial process control, logistics, surveillance systems, and asset management. The company was established by a team of Wi-Fi innovators and is backed by a strong portfolio of intellectual property and patents, facilitating extensive connectivity across the IoT ecosystem. Morse Micro also has offices in China and the United States, enhancing its global reach and capabilities in the wireless technology market.

v2food

Series B in 2020
v2food is a plant-based meat startup that produces legume-based meat alternatives. The company v2 product is a delicious, nutritious alternative for anyone who loves the taste of meat but doesn’t want to get it from animals. It is a safe space to connect with like-minded people and create positive relationships with food that will help them feed the planet in a sustainable way. v2food was founded by Nick Hazell in 2019 and is based in Sydney, New South Wales, Australia.

Kasada

Series B in 2020
Kasada Pty Ltd is an Australian company specializing in cyber-security software solutions. Founded in 2014 and headquartered in Chippendale, Australia, with additional offices in the United States and the United Kingdom, Kasada develops a cloud-based product known as Kasada Polyform. This product focuses on automated bot detection and mitigation specifically designed for enterprise web applications. By addressing the economic challenges associated with the misuse of automation in applications and APIs, Kasada aims to enhance the security posture of organizations against malicious automated threats.

Myriota

Series B in 2020
Myriota was established to solve a very real customer problem: providing access to high value small data in remote locations at low cost. Myriota’s advanced signal processing technologies were created with commercialization at their core. As a result, Myriota is relentless in its pursuit of customer delight and the belief that commercial success is the natural outcome of doing everything right for their customers.

Prospection

Series A in 2020
Prospection Pty Ltd is a Sydney-based company specializing in healthcare data analytics through its software as a service (SaaS) platforms. Founded in 2012, it leverages predictive analytics and machine learning to analyze real-world healthcare data, providing insights that enhance research and improve patient outcomes. The company's key offerings include PharmDash, which tracks patient medication usage and treatment progression, and PharmMap, a platform that integrates commercial and operational data using geospatial mapping. Prospection collaborates with government entities, pharmaceutical companies, and the medical community on over 70 therapy programs, with a focus on areas such as immuno-oncology, HIV, and hepatitis across Australia and the Asia Pacific region.

Advanced Navigation

Series A in 2019
Advanced Navigation is a privately owned Australian company that specializes in the development of navigation technologies and robotics. The company has a focus on generating products of the highest quality standard, both in terms of hardware and software. The company's founders came from a background in mission critical robotics built to military specifications and this can be seen through Advanced Navigation's products. Advanced Navigation's engineers have specialized expertise across a broad range of fields including sensors, GNSS, inertial navigation, RF technologies, acoustics, robotics, AI, and algorithms.

v2food

Series A in 2019
v2food is a plant-based meat startup that produces legume-based meat alternatives. The company v2 product is a delicious, nutritious alternative for anyone who loves the taste of meat but doesn’t want to get it from animals. It is a safe space to connect with like-minded people and create positive relationships with food that will help them feed the planet in a sustainable way. v2food was founded by Nick Hazell in 2019 and is based in Sydney, New South Wales, Australia.

Q-CTRL

Series A in 2019
Q-CTRL Pty Ltd, established in 2017 and located in Pyrmont, Australia, specializes in developing software tools and firmware for the quantum computing sector. The company focuses on addressing critical challenges in quantum technology, such as noise and decoherence, which affect the performance of quantum devices. By leveraging its expertise in quantum control engineering, Q-CTRL provides intuitive software solutions designed to reduce errors in quantum bits, thereby stabilizing quantum hardware. Its offerings are particularly relevant in the NISQ (Noisy Intermediate-Scale Quantum) era, allowing users to better understand and manage the impacts of noise and errors in quantum systems. Through its innovative approach, Q-CTRL aims to make quantum technology more practical and accessible for various applications, including quantum sensing in defense.

Cylite

Series B in 2019
Cylite Pty Ltd is an Australian company based in Notting Hill, specializing in the development of advanced 3D imaging and measurement systems for the ophthalmology and optometry markets. Established in 2001, the company offers innovative products such as the Hyperparallel Optical Coherence Tomography (HP-OCT), which provides comprehensive whole-eye measurement and imaging capabilities. The founding team possesses over 80 years of experience in optics and has successfully developed multiple companies within the optical industry, generating significant revenues. Cylite unveiled its unique imaging platform at the Photonics West/BiOS conference in San Francisco in February 2015, marking a significant advancement in ophthalmic imaging technology.

Kapiche

Seed Round in 2019
Kapiche Pty Ltd. is an Australian company that specializes in text analytics solutions for customer feedback. Founded in 2013 and based in Fortitude Valley, it offers an intelligence-powered analytics platform designed to help organizations centralize and understand feedback data from various sources, including surveys, net promoter scores, and product reviews. The platform enables clients to quickly gain deep, actionable insights from large volumes of feedback, identifying key themes, customer sentiments, and their impacts on relevant business metrics. By eliminating the need for manual coding or extensive reading of comments, Kapiche streamlines the process of deriving meaningful insights from customer and employee feedback, thus enhancing the understanding of customer experience for businesses.

Lumachain

Seed Round in 2019
Lumachain Pty Ltd is an Australian company that develops a software as a service (SaaS) platform for food supply chain management. Established in 2018 and based in Sydney, the platform provides transparency in global supply chains by enabling producers, enterprises, and consumers to trace the origin, location, and condition of individual items in real time, from farm to fork. This traceability encourages farmers and manufacturers to produce high-quality and ethically sourced products. Additionally, it helps enterprises minimize waste, enhance operational efficiency, and increase profitability. Consumers benefit by gaining certainty about the provenance, condition, and quality of their purchases, ensuring they are making informed choices regarding ethically and sustainably sourced food products.

FluroSat

Seed Round in 2019
FluroSat Pty Ltd is an ag tech company based in Eveleigh, Australia, specializing in predictive crop health monitoring through advanced software solutions. Founded in 2016, FluroSat develops a decision support platform that utilizes multispectral and hyperspectral imagery collected from drones and satellites to assess crop health and identify specific stressors affecting yield. Their primary offerings include FluroSat, designed for cotton and grain growers, and ProductionWise, which enhances farm efficiency for commodity crops through features like paddock management, yield predictions, satellite monitoring, and localized weather forecasts. The company also provides consulting services that guide farmers on optimal application rates of fertilizers, fungicides, and irrigation, leading to potential savings on input costs and improved yields. FluroSat currently focuses on the Australian broadacre farming sector and aims to expand its reach internationally.

Fivecast

Venture Round in 2019
Fivecast Pty Ltd, founded in 2017 and based in Adelaide, Australia, specializes in developing advanced software solutions for law enforcement and national security intelligence agencies. Its flagship products, FIVECAST INSIGHT and FIVECAST AI, are designed to tackle complex data challenges in the field. FIVECAST INSIGHT offers capabilities in network analysis, behavioral risk analytics, and visualization, enabling users to extract and profile online footprints of individuals, groups, and networks. Meanwhile, FIVECAST AI enhances risk assessment processes through automated and ongoing evaluations of numerous entities, leveraging machine learning and deep learning techniques to analyze social media data and quantify various risks, sentiments, and topics. The company emerged from the Data to Decisions Cooperative Research Centre, a partnership that focused on understanding the big data challenges faced by national security agencies and led to the creation of its innovative software solutions.

Morse Micro

Series A in 2019
Morse Micro PTY. LTD. is an Australian company specializing in the design and development of wireless chip technology, particularly focused on Wi-Fi solutions for the Internet of Things (IoT). Founded in 2016 and headquartered in Eveleigh, Australia, the company offers Wi-Fi HaLow, a low-power wireless technology that enables connections up to one kilometer, making it suitable for a variety of applications including home automation, industrial process control, logistics, surveillance systems, and asset management. The company was established by a team of Wi-Fi innovators and is backed by a strong portfolio of intellectual property and patents, facilitating extensive connectivity across the IoT ecosystem. Morse Micro also has offices in China and the United States, enhancing its global reach and capabilities in the wireless technology market.

Kasada

Venture Round in 2019
Kasada Pty Ltd is an Australian company specializing in cyber-security software solutions. Founded in 2014 and headquartered in Chippendale, Australia, with additional offices in the United States and the United Kingdom, Kasada develops a cloud-based product known as Kasada Polyform. This product focuses on automated bot detection and mitigation specifically designed for enterprise web applications. By addressing the economic challenges associated with the misuse of automation in applications and APIs, Kasada aims to enhance the security posture of organizations against malicious automated threats.

Baraja

Series A in 2019
Baraja is a 3D machine vision systems manufacturer. It has invented a new type of LiDAR called Spectrum-Scan which delivers the highest performance available to address the challenge of self-driving cars. Baraja is a rapidly growing start-up, with a revolutionary LiDAR for self-driving vehicles. The company is based in Sydney, Australia, with offices in China and the USA. It is quickly expanding worldwide, hiring through Europe and Asia, closely collaborating with car manufacturers to iterate and refine its vision of what LiDAR needs to be.

Emesent

Seed Round in 2018
Emesent Pty Ltd develops and markets hovermap system that collects data in underground areas. It offers complete inspection and mapping of underground assets such as mines, transport tunnels, and utility tunnels. The technology also works in areas that do not have global positioning system (GPS) access. The company was founded in 2018 and is based in Pullenvale, Australia.

RapidAIM

Seed Round in 2018
RapidAIM PTY LTD, founded in 2018 and based in Highgate Hill, Australia, specializes in developing an innovative sensor grid for insect identification aimed at enhancing agricultural pest management. The company addresses the challenge of insufficient information regarding pest threats to food crops by employing a network of low-power sensors integrated with edge computing technology. This platform enables real-time monitoring and analysis of pest activity, providing growers and agronomists with timely alerts and forecasts. By facilitating regional pest surveillance and crop border security, RapidAIM empowers agricultural stakeholders to implement targeted pest control measures, thereby minimizing crop damage and losses.

Gilmour Space

Series B in 2018
Gilmour Space Technologies Pty Ltd, founded in 2012 and headquartered in Pimpama, Australia, focuses on developing low-cost hybrid rockets specifically designed for the small satellite market. The company aims to provide reliable and affordable launch solutions for satellites weighing up to 400 kg. By utilizing proprietary 3D printed fuel, Gilmour Space enhances control over the combustion process, which allows for tailored performance during launches. The firm is positioned to serve research organizations and various clients seeking dedicated access to low Earth orbit, with commercial launches expected to commence from 2020.

Intersective

Series A in 2018
Intersective develops technology and provides services to help educators deliver better experiential learning. The company offers Practera, an experiential education tool that helps educators and employers deliver and manage work-integrated learning from internships to complex, large-scale programs. Founded in 2010, Intersective is based in Darlinghurst, Australia.

Indee Labs

Seed Round in 2018
Indee Labs is developing hardware for gene delivery. Our hardware is uniquely positioned for the efficient development and scalable manufacture of gene-modified cell therapies such as chimeric antigen receptor T cells. The technology is being developed with the help of the Australian National Fabrication Facility. We are alumni of NSW Health, IndieBio, Y Combinator and MBC Biolabs (née QB3@953). We are opening up an office in Sydney and have lab space at Bonneville Labs in Berkeley.

Coviu

Seed Round in 2018
Coviu Global Pty Ltd provides telehealth tool to practitioners to help deliver video healthcare consultations to patients. It also offers practice management systems for patient record management. Its tool provides facilities, such as waiting area, customized clinics, dashboard, clinical governance, and white labelling. The company is incorporated in 2015 and is based in Sydney, Australia.

Myriota

Series A in 2018
Myriota was established to solve a very real customer problem: providing access to high value small data in remote locations at low cost. Myriota’s advanced signal processing technologies were created with commercialization at their core. As a result, Myriota is relentless in its pursuit of customer delight and the belief that commercial success is the natural outcome of doing everything right for their customers.

FluroSat

Seed Round in 2017
FluroSat Pty Ltd is an ag tech company based in Eveleigh, Australia, specializing in predictive crop health monitoring through advanced software solutions. Founded in 2016, FluroSat develops a decision support platform that utilizes multispectral and hyperspectral imagery collected from drones and satellites to assess crop health and identify specific stressors affecting yield. Their primary offerings include FluroSat, designed for cotton and grain growers, and ProductionWise, which enhances farm efficiency for commodity crops through features like paddock management, yield predictions, satellite monitoring, and localized weather forecasts. The company also provides consulting services that guide farmers on optimal application rates of fertilizers, fungicides, and irrigation, leading to potential savings on input costs and improved yields. FluroSat currently focuses on the Australian broadacre farming sector and aims to expand its reach internationally.

Morse Micro

Seed Round in 2017
Morse Micro PTY. LTD. is an Australian company specializing in the design and development of wireless chip technology, particularly focused on Wi-Fi solutions for the Internet of Things (IoT). Founded in 2016 and headquartered in Eveleigh, Australia, the company offers Wi-Fi HaLow, a low-power wireless technology that enables connections up to one kilometer, making it suitable for a variety of applications including home automation, industrial process control, logistics, surveillance systems, and asset management. The company was established by a team of Wi-Fi innovators and is backed by a strong portfolio of intellectual property and patents, facilitating extensive connectivity across the IoT ecosystem. Morse Micro also has offices in China and the United States, enhancing its global reach and capabilities in the wireless technology market.

Q-CTRL

Seed Round in 2017
Q-CTRL Pty Ltd, established in 2017 and located in Pyrmont, Australia, specializes in developing software tools and firmware for the quantum computing sector. The company focuses on addressing critical challenges in quantum technology, such as noise and decoherence, which affect the performance of quantum devices. By leveraging its expertise in quantum control engineering, Q-CTRL provides intuitive software solutions designed to reduce errors in quantum bits, thereby stabilizing quantum hardware. Its offerings are particularly relevant in the NISQ (Noisy Intermediate-Scale Quantum) era, allowing users to better understand and manage the impacts of noise and errors in quantum systems. Through its innovative approach, Q-CTRL aims to make quantum technology more practical and accessible for various applications, including quantum sensing in defense.

Maxwell Plus

Seed Round in 2017
Maxwell Plus is an AI platform for data driven clinical diagnostics. Maxwell Plus gives clinicians, researchers, and companies the tools they need to accelerate the design, development, delivery of clinical diagnostics built upon medical imaging, pathology and other data. The first diagnostic model available on Maxwell is for prostate cancer.