Maryland Innovation Initiative (MII)

Gelectric Medical specializes in an innovative electrical adhesive gel patch that provides secure adhesion to tissue surfaces via the application of an electric field, enabling targeted treatment in areas where traditional sutures may not suffice.

Prompt Diagnostics is a biotechnology firm that supports rapid, inexpensive, simple-to-use diagnostic testing that nevertheless offers uncompromised sensitivity and specificity for illness identification at the point of care.

Blue and Green Energy Solutions offers an innovative floating hybrid tidal/wave/wind energy harvesting system.

ComputChem is a technology firm that develops cutting-edge platform solutions for lead optimization and in silico covalent drug creation.

Kubanda Cryotherapy offers minimally invasive, non-surgical treatment for lumps, bumps, and cancers in pets. The companies custom-designed cryosystem consists of a cryoprobe and a gas-control module made to modulate temperature. This system creates freezing cycles proven to shrink and kill tumors.

Geminus Therapeutics is developing best-in-class Artemisinin (ART714) for treating leukemia.

ML4Cyber develops an automated approach to analyzing software code for vulnerabilities in technology for commercial solutions. They offer a machine learning approach to identify both true positives and false positives. Contact ML4Cyber at contact@ml4cyber.com.

PreSquared is a healthcare technology company specializing in predictive analytics aimed at enhancing care management. The company develops software that integrates predictive machine learning solutions into the provider workflow, generating actionable data that facilitates timely interventions and mitigates the risk of significant health events. By enabling healthcare organizations to prioritize patient care based on risk levels, PreSquared seeks to improve the overall efficiency of the healthcare ecosystem and support caregivers and patients in making informed decisions.

Synteris is focused on the development and manufacturing of advanced precursor powders for 3D printing of high-temperature ceramics. The company specializes in producing non-oxide ceramic parts, including carbides, nitrides, and borides, through a technique known as selective laser reaction sintering (SLRS). This innovative approach allows for the rapid production of prototypes and parts that can be utilized in various applications, particularly in enhancing heat sinks and cooling architectures within the electronics industry. By addressing the growing demand for efficient electrical components, Synteris positions itself as a key player in the evolving landscape of advanced manufacturing technologies.

Empower Therapeutics is a digital therapeutics company focused on noninvasive neuromodulation to manage pain sensitivity. The company is developing a platform that employs functional targeting and reliable EEG-based biomarkers, which aid clinicians in assessing and adjusting pain sensitivity in patients. This innovative approach aims to assist individuals suffering from chronic pain by reducing their reliance on opioids and other analgesics, offering a potentially safer alternative for pain management.

BLOCKsyncop is developing a non-invasive real-time tool for the anesthesiologist.

Evincis Bio is a company focused on addressing therapeutic challenges in urology through the development of innovative medical technologies. It specializes in gene therapy solutions aimed at restoring erectile function. Currently operating in stealth mode, Evincis Bio is dedicated to advancing its research and technology to improve patient outcomes in urological health.

Capsulomics, LLC is a biotechnology company focused on developing and manufacturing DNA tests for the early detection of upper gastrointestinal (GI) cancers, particularly esophageal cancer and its precancerous condition, Barrett’s esophagus. Founded in 2018 and based in Halethorpe, Maryland, Capsulomics aims to address the diagnostic and prognostic uncertainties associated with GI diseases. By providing advanced diagnostic solutions, the company enables healthcare professionals to prevent, detect, and treat these conditions more effectively, ultimately enhancing patient outcomes.

Silvec Biologics specializes in developing RNA therapies aimed at treating and preventing diseases in trees, vines, and bushes. By employing RNA-based molecules, the company offers innovative solutions that eliminate the need for genetic modification. Its therapies work by introducing virus-like RNA into the plant's vascular system, effectively targeting and destroying viral and fungal pathogens. This approach not only safeguards the health of these plants but also supports food growers in maintaining abundant and diverse food supplies, thereby contributing to the preservation of natural resources and ensuring sustainability for future generations.

Haystack Solutions specializes in identifying cybersecurity talent for corporations, educational institutions, and workforce development organizations. The company provides a cyber talent platform that includes aptitude and talent assessment tests designed to evaluate an individual's potential success in the cybersecurity field. By focusing on the recruitment and retention of candidates, Haystack Solutions enables its clients to effectively hire qualified cybersecurity professionals, thereby addressing the growing demand for skilled talent in this critical area.

Geothermal Technologies is a company focused on geothermal energy exploration and production, aiming to address global energy challenges through innovative solutions. The company develops advanced technologies that facilitate the extraction of clean, renewable geothermal energy, providing economically viable baseload electricity worldwide. By leveraging a sophisticated underground heat harvesting system, Geothermal Technologies integrates state-of-the-art oil and gas production methods with modern power generation technologies. This approach seeks to overcome the limitations of previous enhanced geothermal system (EGS) efforts, enabling the deployment of utility-scale geothermal power. Ultimately, Geothermal Technologies is dedicated to making clean energy more accessible and competitive, contributing to a sustainable energy future.

OncoSTING, located in Baltimore, is developing novel bladder cancer therapies that work by combining the potency of standard BCG immunotherapy with long-lived delivery of potent STING agonists. (JHU)

ACTIVEcharge, based in Baltimore, specializes in developing innovative systems that harness wasted vibrational and kinematic energy to generate electrical power for battery-free sensor operations, particularly in wind-powered turbines. The company’s technology integrates a predictive analytics software engine that monitors hard-to-reach locations, identifying structural and operational issues before they escalate into significant problems. This proactive approach allows clients to implement actionable insights autonomously, enhancing equipment uptime and ultimately boosting profitability over the equipment's lifespan. By focusing on sustainability and efficiency, ACTIVEcharge offers solutions that address modern operational challenges in various industries.

Bluelene is an online retailer specializing in face care products that focus on anti-aging and skin health. The company utilizes a patented ingredient, methylene blue, which penetrates human cells to enhance mitochondrial function. This innovative approach not only improves overall skin health but also aids in repairing aging damage and protecting against sun exposure. Bluelene's formulations are designed to extend the lifespan of skin cells, thereby promoting better connective tissue and facilitating wound healing. Their products cater to both men and women, offering effective solutions for maintaining healthy skin.

Renalert, based in Baltimore, specializes in the early detection of acute kidney injury (AKI) through a sophisticated monitoring system. This system precisely measures urine output while correlating these values with vital signs such as blood pressure and oxygenation. By employing a proprietary algorithm, Renalert's technology enables medical professionals to estimate renal perfusion and detect early declines in kidney function. This innovation aims to prevent needless fatalities associated with AKI by allowing timely intervention and treatment.

Sonoval LLC is a biotechnology company based in Baltimore, Maryland, focused on developing innovative protein-based therapies for cancer treatment. Established in 2017, the company is working on a novel drug, SON-211, which targets T-cell lymphomas and various solid tumors. This therapy operates by binding to receptors on tumor cells, delivering a toxic payload that not only destroys cancerous cells but also helps eliminate immune system suppressors, thereby enhancing the body's own anticancer defenses. Through its advanced platform, Sonoval aims to provide effective immunotherapies that can significantly improve treatment outcomes for patients with challenging cancer types.

Mind-X combines neurotechnology, augmented reality, and Artificial Intelligence to create computer interference. The company develops an interface framework combining brain-computer interfaces and artificial intelligence designed for spatial computing applications. Founded in 2017 by Geoffrey Ling and Julia Brown, Mind-X is headquartered in Bethesda, Maryland.

Gardner Industries specializes in developing analytical tools for research that focus on measuring microbial growth and enzyme activity, particularly in relation to insoluble substrates. Their flagship product, the Substrate Cage™, was initially designed to assess the degradation rate of bacterial lignocellulose but has since been adapted for various other insoluble biopolymers. This innovative tool is user-friendly and compatible with standard laboratory equipment, allowing researchers to obtain rapid, real-time measurements without delays in data acquisition. By facilitating the study of bioconversion processes, Gardner Industries supports advancements in the field of microbiology and enzymology.