MassChallenge

CNS Therapy is a spin-off from the University of North Carolina that develops mind-body therapy-based solutions and devices to alleviate chronic pain and related conditions. It combines operant behavioral therapy with a proprietary device called SET, Systolic Extinction Training, to enhance learning and reset the autonomic nervous system, with the aim of delivering long-lasting pain relief. The company tracks physiological parameters and uses the resulting data to optimize therapy, delivering an integrated program of psychological training and electrostimulation to help patients reduce or eliminate pain and return to daily activities.

HeroSupport is a medical device manufacturing company founded in 2019 and based in Veyrier, Geneva. The company specializes in creating medical immobilization devices designed to enhance patient comfort during clinical procedures. Its innovative technology transforms imaging and treatment tables into personalized support solutions, specifically catering to the needs of patients undergoing prone breast radiotherapy. This approach allows patients to benefit from tailored support, eliminating the need for them to adjust to the standard table. By improving patient comfort, HeroSupport enables healthcare providers to deliver more effective and cost-efficient cancer treatment.

Drizzle Health develops affordable, high-performance diagnostics for tuberculosis and other bacterial infections. Their innovative tools enable real-time detection of bacteria in various environments, improving testing accuracy, reducing healthcare costs, and ensuring food and water safety.

PlusVitech specializes in developing safe and effective therapeutic treatments for cancer patients. Its innovative approach focuses on non-invasive genetic cancer detection using small molecule and monoclonal antibody therapies, aiming to enable early diagnosis and treatment.

Aevice Health specializes in non-invasive wearable technology for real-time monitoring of respiratory health. Its devices facilitate early detection of cardiopulmonary issues, enabling clinicians to track patient responses to treatment effectively and enhancing patient care by delivering critical insights directly from home.

DocNexus is transforming the healthcare landscape by utilizing AI-powered knowledge graphs to enhance medical affairs organizations. The company has developed a platform that enables rapid access to insights from millions of scientific publications, clinical trials, and news, significantly reducing the time required to gather critical information. Its offerings include a comprehensive database for key opinion leader (KOL) searches, advanced publication searches to support effective scientific exchanges, and news aggregation to keep clients informed about KOLs' digital media presence. Through these capabilities, DocNexus facilitates seamless connections within the healthcare ecosystem, empowering clients to advance their medical affairs strategies effectively.

XN Health is a medical device company founded in 2021 and based in Texas, USA. The company focuses on developing innovative healthcare solutions to assist mechanically ventilated patients in weaning off ventilators more efficiently. Its primary product utilizes phrenic nerve stimulation to induce diaphragm contractions, thereby mitigating the risks of diaphragm dysfunction associated with prolonged mechanical ventilation. By enhancing the weaning process, XN Health aims to improve patient outcomes and facilitate recovery in critical care settings.

Lighthanded Enterprises specializes in innovative medical technology focused on diagnosing middle ear effusions, particularly otitis media with effusion (OME), which is common in childhood. The company has developed a laser otoscope that significantly enhances diagnostic capabilities by providing an additional illumination source. This advanced platform offers up to ninety percent accuracy in detecting OME, allowing physicians to confidently assess and manage conditions that can adversely affect a child's hearing over prolonged periods. By improving visibility during examinations, Lighthanded Enterprises equips healthcare providers with the tools necessary for more effective treatment and referral decisions.

Eztia manufactures wearable cooling products designed to protect users from extreme heat. Their innovative technology enables on-the-go icing, ensuring safety for both people and the environment.

Taurus Vascular is a medical device company dedicated to enhancing long-term outcomes for patients suffering from aortic aneurysms. The company is focused on transforming the standard of care by developing innovative medical device technology aimed at addressing the complications associated with endoleaks. This technology is designed to facilitate accelerated shrinkage of the aneurysm sac following endovascular aortic aneurysm repair (EVAR). By improving the effectiveness of treatment, Taurus Vascular aims to significantly enhance patient outcomes in the healthcare sector.

Qonect offers a free digital platform that enables users to save on food and medical bills by providing discounts on medicines and lab tests, facilitating OPD appointments, and offering financial assistance during medical emergencies.

Pharmesol is a clinical services company that develops a platform to automate follow-up care for medications. The platform uses artificial intelligence to automate calls and messages, streamlining communication among patients, providers, and payers, and supports data management with recorded documentation. This enables patients and doctors to receive personalized support around the clock.

Anviron is a biotechnology company that develops small-molecule inhibitor therapies for aggressive and late-stage cancers. The company focuses on scientific research to halt or shrink tumor growth in cancers such as pancreatic, breast, gastric, and cervical cancers, aiming to provide healthcare professionals with potential new treatment options. It employs a team of scientists, doctors, and clinicians dedicated to advancing cancer therapies.

Flagler Health develops clinical decision support software that helps healthcare providers deliver more comprehensive care. Its platform uses patient data and clinical guidelines to identify potentially beneficial procedures that might have been overlooked, improving patient outcomes.

SafeGuard Surgical is a medical device company focused on improving surgical outcomes and patient safety. It develops innovative, resorbable products designed to enhance colonic anastomotic healing and stability during advanced surgical procedures. These include a resorbable intraluminal stent graft and an extraluminal resorbable graft, along with anvil cap extension arms. By employing these products, SafeGuard aims to reduce surgical complications, lower healthcare costs, and minimize patient recovery time, ultimately preventing mortality and morbidity associated with surgery.

KardioStatus is a healthcare technology company that converts biometric data into personalized clinical treatments. Its platform, developed by leading physicians and engineers, creates unique biometric profiles for patients and provides tailored therapeutic recommendations to healthcare providers, aiming to enhance patient outcomes, lower costs, and simplify decision-making processes.

Hybridwerx enables clinicians to enter notes fast and focus on assisting patients.

Cellorama multipurpose devices, reagents, and processes are patent-pending and protect cell structure and integrity during many procedures. User-friendly and cost-effective devices are designed to minimize stressful stages in the laboratory while saving time and vital resources.

SAFE4BOTH is a care strategy that supports moms with OUD and their substance-exposed child by promoting optimal prenatal and postpartum care and support. The platform supports moms in their recovery process by utilizing evidence-based treatment plans, case management, and behavioral health approaches.

Lura Health develops a non-invasive continuous health monitoring platform that uses saliva as a diagnostic fluid. The company integrates micro-sensors into orthodontic devices such as retainers, aligners, and brackets to continuously measure saliva analytes and securely transmit data to a smartphone app, enabling users to monitor oral health metrics and potentially support broader chronic disease management. Target markets include heart disease, chronic kidney disease, diabetes, and tooth decay. Founded in 2017, the company is based in Cambridge, Massachusetts.

Oatmeal Health is a virtual clinic specializing in cancer care, enhanced by AI technology. It offers services such as lung cancer screening, risk assessments, diagnosis support, care navigation, and patient education. The company partners with community health centers, health systems, and imaging centers to provide high-quality, patient-centered care.

Form Biologics is a new platform technology for the injectable formulation of biologic medicines in order to make treatments more patient-friendly and efficacious.

Speratum is a biopharmaceutical company focused on microRNA-directed oncology therapies. The Company was founded in 2014 by Christian Marín-Müller, Ph.D. and is dedicated to the development of a patented treatment for pancreatic cancer based on the combination of tumor suppressive microRNA molecules and nanoparticle-based drug delivery technologies. The Company is currently entering the final stage of preclinical trials for the pancreatic cancer therapy, while simultaneously expanding the patent’s coverage to incorporate other types of cancer and non-cancer indications and illnesses and expanding its intellectual property (IP) portfolio with complementary technologies in the fields of nanotechnology, medical devices and veterinary medicine.

Corveus Medical is a medical device company focused on innovative solutions for preventing heart failure. The company is developing a neuromodulation device designed to perform nerve ablation through a catheter-based approach. This minimally invasive technology aims to effectively target and access specific tissues, offering a novel treatment option for heart failure. By addressing both the clinical and economic challenges associated with this condition, Corveus Medical seeks to improve patient outcomes and enhance the overall management of heart failure.

3D Orthobiologic Solutions is creating a 3D-printed scaffold that may be customized for healing and rebuilding bone in oral and maxillofacial surgery.

Auspex Diagnostics specializes in advanced diagnostic tests for personalized cancer treatment. It leverages AI and data analytics technologies to help healthcare providers make informed treatment decisions, enhancing patient care.

Perfusion Medical is a biopharmaceutical company focused on developing acute cardiovascular therapies for shock and ischemic conditions. It is advancing an intravenously administered PEG-20k solution that increases tissue perfusion to rapidly restore oxygen delivery to tissues during severe blood loss, supporting resuscitation and potentially reducing reliance on blood products by enhancing transfusion effectiveness in critical care. The approach targets emergency and trauma settings with the aim of transforming management of hypovolemic shock and related conditions by restoring perfusion and limiting tissue injury.

Elythea is a technology company that develops a medical platform for obstetricians. This platform uses machine learning and deep learning algorithms to predict pregnancy complications, such as postpartum hemorrhage, cesarean section, and eclampsia, by analyzing clinical history and demographic information available at the point of care. The platform can make these predictions as early as the first trimester, enabling doctors to prepare and reduce mortality and costs by over 90%. Elythea's proprietary models outperform current gold standard risk assessments, demonstrating up to three times greater sensitivity in predicting high-risk cases of hemorrhage.

CranioSense develops non-invasive medical devices to diagnose and monitor intracranial hypertension, providing clinicians with crucial insights for treating neurological conditions.

Azooka Labs specializes in the production of proprietary fluorophores for biotechnology applications. Their products include fluorescent dyes and tags for DNA, RNA, chromosomes, live cells, and molecular-grade sample collection mediums. The company aims to provide affordable and sustainable biotech consumables globally.

Walkky develops a digital healthcare platform that uses artificial intelligence to analyze electrocardiogram data and build personalized patient profiles. The system detects, predicts, and alerts clinicians to significant cardiac events and abnormal or declining heart function, enabling faster proactive cardiovascular diagnostics.

True Concepts Medical Technologies develops medical devices designed to reduce financial waste in healthcare while improving patient outcomes. The company creates cost-effective, manufacturable devices that address critical clinical needs, minimize human error, and improve diagnostic and treatment delivery. Its product development team applies broad experience in medical device design to support rapid development for clinician-inventors, startups, and manufacturers. The firm focuses on areas with high morbidity and mortality, delivering contaminant-free blood culture collection tools to improve sepsis diagnosis and support life-saving emergency care. Founded in 2017 and based in Centerville, Ohio, the company pursues solutions that can lower costs and enhance patient safety across the healthcare system.

Astron Medtech specializes in developing disposable, minimally invasive surgical devices for tendon repair. Their innovative solutions aim to reduce recovery time by half, from six months to four.

Curespec is a medical device company developing the Nephrospec, a non-invasive device designed to treat chronic kidney disease and hypertension. By preserving kidney function and delaying the need for dialysis, the technology supports clinicians in managing renal and hypertensive conditions and aims to reduce patient suffering.

TrainFES is a digital neuro-rehabilitation platform focused on enhancing the quality of life for individuals with paralysis, including those with spinal cord injuries and complications from cerebrovascular accidents. The company offers an innovative solution that combines rehabilitation orthopedic devices with a mobile application, enabling patients to undergo rehabilitation in the comfort of their own homes. This approach not only reduces the costs associated with traditional rehabilitation therapies but also aims to deliver improved outcomes for users. By providing effective monitoring and therapeutic support, TrainFES empowers individuals to manage their physical disabilities and engage in their rehabilitation more effectively.

Red Arrow Therapeutics is a biotechnology company developing innovative cancer therapies. It focuses on systemic cytokine delivery, targeted intratumoral activation, and enhancing biological potency to maximize drug efficacy while minimizing toxicity.

Malama Health improves pregnancy-related outcomes by providing software that enhances the care offered by OB/GYNs. Its platform offers a glucose tracker, identifies food triggers, provides one-on-one coaching, and delivers actionable insights to optimize maternal health.

Stellate Therapeutics is a global biotechnology company specializing in the development of small molecules derived from human gut bacteria into personalized therapies for neurological diseases. The company's platform has generated a portfolio of new drug candidates, with capabilities spanning discovery, screening, production, and diagnostic development.

Trove Health is a company that offers a clinical trial recruitment platform designed to facilitate access to patient data for patients, healthcare providers, and life sciences organizations. The platform creates a diverse and consented database of prospective trial participants, enabling researchers to efficiently identify and recruit patients who meet specific enrollment criteria across various geographies and therapeutic areas. By doing so, Trove Health supports the advancement of medical research while empowering patients to manage their own health data, including the potential to monetize it and receive personalized treatment options.

SensArs specializes in medical equipment manufacturing, focusing on neuromodulation solutions. Its flagship product, SENSY, is an innovative healthcare technology system designed to restore natural sensations to the feet for patients who have undergone amputations or suffer from nerve damage due to diabetic neuropathy.

Wisedocs provides a machine-learning software platform for reviewing medical records used by insurance, legal, and independent medical evaluation firms. The platform helps organizations organize and interpret unstructured medical data, supporting auto, liability, disability, workers’ compensation, tort law, and related markets. It offers easy integration and features such as automated indexing, duplication detection, and custom tools to streamline back-office document processing, improve accuracy, and increase efficiency in medical record handling.

Founded in 2019, SOAP Health improves clinical decision-making by capturing and analyzing patient data before appointments. Its platform offers augmented intelligence for physicians, graphical risk representation, and actionable insights to enhance patient care and doctor productivity.

CardMedic is a healthcare platform designed to enhance communication between healthcare staff and patients, addressing various barriers such as language differences, visual and hearing impairments, cognitive challenges, and literacy issues. The platform features a comprehensive library of digital flashcards that replicate clinical conversations on common healthcare topics. These flashcards are available in multiple formats, including multilingual options, sign language, easy-to-read text, and read-aloud capabilities. By facilitating clearer communication, CardMedic aims to improve the quality of care and reduce health inequalities, ensuring that patients can access essential healthcare information in a way that is understandable to them. The platform is accessible via smartphones, tablets, or desktops, making it a versatile tool for both patients and healthcare providers.

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.

Ferrum Health, Inc. is a health technology company based in Santa Clara, California, that specializes in developing an artificial intelligence platform aimed at preventing medical errors and enhancing patient safety. Incorporated in 2017, Ferrum Health's AI-driven platform analyzes patient data across healthcare systems to identify opportunities for closing gaps in care. The platform features a comprehensive patient safety evaluation system, which includes multiple computer vision algorithms that assess radiologic images for commonly missed conditions, such as lung nodules and fractures. Additionally, it employs proprietary natural language processing algorithms to correlate findings with physician notes, effectively flagging potential oversights for hospital quality officers to address. By integrating AI, Ferrum Health strives to improve patient outcomes and support hospital systems in maintaining high standards of care.

Canopie is a mental health care company focused on addressing maternal depression and anxiety through a digital platform. The platform offers customized, audio-based programs and automated coaching that utilize clinically validated therapeutic techniques, including adaptations of cognitive behavioral therapy and compassion-focused treatment. By collaborating with cities, payers, health systems, and healthcare providers, Canopie aims to deliver effective and affordable care for mothers, overcoming barriers such as cost, scheduling, time, and stigma. The company's innovative approach is designed to support pregnant women and new mothers in preventing and treating common mental health challenges, making it a scalable solution in maternal mental health care.

Eupnoos is a health-tech company specializing in digital lung health solutions. It offers smartphone-based, automated lung function testing and data interpretation for various devices and telehealth platforms.

Together by Renee is a free app that uses generative AI to streamline and automate health tasks like ordering refills, booking appointments and completing forms in an easy user experience perfect for the 123 million aging Americans managing diabetes, obesity, hypertension, and more. Together measures vital signs like blood pressure via smartphone camera - with no devices or wearables required. Together requires no data entry, typing or integration to legacy systems, using just AI to automate patient-centric care coordination. 67% of Together’s first 15,000 users are over 55 years of age and Together enjoys NetPromoter score of +85.

Patientory is a digital health data platform that enables individuals to store and manage personal medical records and health information, empowering patients to control their data. The platform securely manages records, offers AI-driven health coaching, tracks wellness metrics, connects users to clinical trials and affordable medications, and rewards healthy behaviors. It facilitates connections between patients and healthcare providers to support care coordination. Founded in 2015 and based in Atlanta, the company aims to streamline access to health information and enable patients to benefit from their data.

Carium is a provider of an individualized healthcare platform designed to improve health and wellness journeys. The platform offers an end-to-end, actionable, and personalized care experience for patients and care teams, enabling healthcare providers and payers to reduce costs, gain better insights, and achieve better health outcomes. It supports coordination across care settings and emphasizes data collected from daily life to inform clinical decisions.

Delfina is a data-driven prenatal care platform that personalizes pregnancy care to improve safety for mothers and babies. It uses a data-powered approach to uncover insights in prenatal care and to optimize interventional workflows through machine learning models. The platform creates individualized pregnancy care plans based on patient risk assessed from multiple metrics and supports early intervention, helping providers deliver equitable, cost-effective care. By integrating data across clinical, demographic, and monitoring inputs, Delfina aims to enhance decision-making, streamline workflows, and improve outcomes throughout pregnancy.

CardMedic is a healthcare platform designed to enhance communication between healthcare staff and patients, addressing various barriers such as language differences, visual and hearing impairments, cognitive challenges, and literacy issues. The platform features a comprehensive library of digital flashcards that replicate clinical conversations on common healthcare topics. These flashcards are available in multiple formats, including multilingual options, sign language, easy-to-read text, and read-aloud capabilities. By facilitating clearer communication, CardMedic aims to improve the quality of care and reduce health inequalities, ensuring that patients can access essential healthcare information in a way that is understandable to them. The platform is accessible via smartphones, tablets, or desktops, making it a versatile tool for both patients and healthcare providers.

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.

Ostiio develops an innovative bone distraction system designed to correct skeletal deformities and deficiencies. Its fully implantable device is buried under the patient's skin, eliminating the need for external components, and features a programmable driver that enables remote monitoring and control by prescribing surgeons.

miniMarrow presents a new disruptive therapeutic approach for the in-situ production of blood components in leukemic patients to replace weekly and burdensome transfusions markedly increasing patient quality-of-life. miniMarrow is operating in stealth mode. miniMarrow was established in Renens, Vaud

CaringWire is a digital health platform focused on enhancing the healthcare experience for individuals, families, and businesses. The platform offers a comprehensive suite of services, including behavioral health, virtual primary care, online pharmacy, family planning, estate planning, and family caregiving. By integrating various healthcare solutions into a user-friendly ecosystem, CaringWire enables users to conveniently and affordably manage their health and wellness needs. The company collaborates with the University of Wisconsin School of Nursing to ensure that its offerings are informed by the latest research, providing members with reliable guidance and support. CaringWire's mission is to make healthcare more accessible and manageable, positioning itself as a primary digital solution for accessing trusted care.

Opsin Biotherapeutics specializes in the development of gene therapies based on opsins, a class of light-sensitive proteins. The company's primary focus is to create a pipeline of treatments for pain management, aiming to provide effective alternatives to opioids.

MediCircle uses technology to reduce pharmaceutical waste and remove barriers to care by collecting leftover oral chemotherapeutics, validating their quality, and redistributing them to patients in need; the platform provides a safe, low-cost alternative to disposal and helps generate savings for patients, insurers, and healthcare facilities while improving community health. The model repurposes unused prescriptions through pharmacies, tracking donation history and assessing potency and purity to address disparities in access to affordable care.

WestFace Medical is a medical device company focused on enhancing vascular access procedures through its innovative product, SingleStick™. This device employs patented needle tip imaging using optical coherence tomography (OCT) to provide real-time visualization of the needle's trajectory. SingleStick™ consists of a handheld imaging adapter that can be attached to any hollow bore needle, along with an OCT image processor. The adapter introduces an optical fiber into the needle, allowing clinicians to view anatomical markers in real-time as they perform vascular access. This technology aims to redefine the standard of care in medical procedures, ultimately improving clinical outcomes, reducing costs, and increasing patient satisfaction. By facilitating traditional vascular access techniques with advanced imaging capabilities, WestFace Medical addresses significant challenges in pediatric care and beyond.

Selmod, based in Basel's life science hub, develops innovative antibiotics targeting multi-drug resistant infections. Its first-in-class drug candidates focus on high-revenue hospital patients where first-line treatments have failed due to resistance. With a disruptive approach featuring new dual modes of action, all candidates have shown success in animal infection studies. The company aims to capture a significant share of the estimated $9 billion total available market for its three lead assets.

Ronawk is a biotechnology company specializing in the development of T-Block technology that produces patient-specific biologics for the treatment of various diseases, including cancer, organ injuries, and burns. The company's proprietary method allows for the growth of primary stem cells in a three-dimensional environment, preserving the essential characteristics of these cells outside the human body. This innovative approach enables the rapid expansion of stem cells, facilitating their use in early-stage diagnostics and the repair of damaged tissues. Ronawk's technology not only enhances the efficiency of growing human cells but also supports tissue generation and disease modeling, making significant contributions to the fields of regenerative medicine and reconstructive surgery.

Agile Focus Designs automates and accelerates microscopic imaging with fast focus and zoom technology without any moving parts. This electronic control of true optical zoom and focus without complex algorithms revolutionizes the way microscopes can be used.

Galileo Innovations develops human performance-optimizing biotech gear and equipment for athletes, first responders, military members, and labor industry workers. Its proposed technology, KordoFan, augments users with actionable insights concerning environmental and biometric hazards in real-time to target heat injuries; through an array of biomimicry cooling designs, the device aids in speed, agility, mental clarity, muscle recovery, strength, and stamina during training/shifts.

MyoGene Bio is a biotechnology company focused on developing innovative therapies for muscle diseases, with an initial emphasis on gene-editing treatments for Duchenne muscular dystrophy. The company employs advanced technologies to address the underlying causes of this condition, aiming to significantly improve disease progression and outcomes for patients. By targeting the root of the disorder, MyoGene Bio seeks to provide clinicians and patients with effective solutions that have a meaningful impact on the management of devastating muscle disorders.

Netnoids Rx Laboratories operates a cancer contract research organization that uses patient-derived organoid model systems to help find a cure for rare cancers.

Mutuus is a digital healthcare membership platform based in Mexico that provides members with comprehensive, end‑to‑end medical services through a user‑friendly interface. The service includes free healthcare benefits, discounts on medical services, and full coverage for treatments. Users can book home appointments, track physical activity, receive healthy meal suggestions, request ambulance services, and access 24/7 medical, nutritional, and emotional support. The platform is designed to make private healthcare accessible and affordable for both individuals and businesses, eliminating additional costs for hospital treatments.

Labinnova detects Breast Cancer in a Breath Sample with 98% sensibility. providing Qualitative results.

MoviWear is a company specializing in medical AI and remote monitoring solutions, with a focus on enhancing the safety and health of seniors. Its flagship platform, MoviWearMED, enables real-time health monitoring through proprietary 5G IoT NurtureWatch wearables. This technology allows for continuous tracking of vital signs, including heart rate, temperature, blood pressure, and oxygen levels, as well as fall detection, whether individuals are at home, in retirement communities, or on the move. Designed to respond to the critical need for 24/7 health monitoring outside of hospital settings, MoviWearMED provides instant alerts when there are significant changes in a patient's condition. Since its establishment in 2017, MoviWear has collaborated with various health and telecommunications companies across North America, Europe, and Israel, aiming to prevent health crises and improve quality of life for seniors.

LIALT Laboratorio de Investigación Alternativa develops toxicological evaluations without the use of animals. LIALT replaces the use of animals through the use of three-dimensional tissues in conjunction with internationally recognized protocols that provide more specific information on the mechanisms of toxic action than that obtained in animals, offering a solution to the problem previously exposed.

Nightingale Caring Solutions enhances hospital operations by offering nursing care analytics. It employs machine learning algorithms to analyze relationships between nurses and patient outcomes, optimizing nurse staffing, scheduling, and assignments.

NurLabs develops label-free and reagent-free diagnostics to detect cancer early when it is most treatable.

ModoScript is a developer of innovative digital healthcare solutions focused on enhancing remote treatment monitoring and big data analytics for high-cost specialty pharmaceuticals, particularly Oral Oncolytics. The company aims to improve the efficiency of medication and treatment protocols, ultimately leading to better patient outcomes in managing chronic diseases like cancer. By leveraging a customizable data analytics model, ModoScript provides pharmaceutical companies, health insurance providers, and medical practices with tools to assess treatment progress and support direct-to-patient clinical trials from home. The company collaborates with mail-order specialty pharmacies and in-office medically integrated pharmacies to facilitate remote treatment delivery. ModoScript is dedicated to ensuring that patients receive high-quality care regardless of their race, condition, or socioeconomic status, striving to make their solutions accessible at no cost to patients while reducing overall industry costs.

Onye is a health technology company focused on building solutions that power and add value to both patients and healthcare providers. The company's product is a mobile-first web-based electronic health record system for healthcare providers to improve their clinical and administrative workflows.

Augmental Technologies, Inc., established in 2019 and headquartered in Boston, Massachusetts, specializes in developing innovative, hands-free technology that integrates with the human body. The company focuses on augmented reality and assistive technology, aiming to provide information access and assistance to users with both situational and severe motor impairments. By targeting the mouth as an unexplored interface for human-computer interaction, Augmental enables users to overcome physical and sensory limitations, enhancing autonomy and mobility, particularly for those living with upper extremity paralysis.

Akttyva Therapeutics develops targeted therapeutics to address cell barrier dysfunction across multiple indications.

Histofi is a digital health platform focused on enhancing cancer care through AI-enabled diagnostic and treatment resources. The company operates a software-as-a-service platform that collaborates with local Histofi Partner Providers (HPPs) to deliver comprehensive solutions to healthcare providers globally. Histofi distinguishes itself by effectively integrating advanced technologies and services into a user-friendly model, allowing for efficient scaling to reach more patients in need. The platform is designed to provide cost-effective and high-quality diagnostic information, facilitating the generation of physician-interpretable disease scores, particularly beneficial in developing countries. Histofi aims to improve the quality of life for patients by supporting their wellness goals and promoting effective treatment outcomes.

Transcera is a biotechnology company that develops a lipid-based drug delivery system. This platform enables precise targeting of therapeutic molecules, allowing large molecules to cross cellular barriers for improved treatment of chronic diseases.

Kinder is a full-service digital pediatric clinic that combines digital health with concierge care, bringing the pediatrician back to the family's living room.

Neurava specializes in developing wearable diagnostic devices for epilepsy patients. Their products monitor health metrics, alert users and healthcare providers to seizures and cardiorespiratory dysfunctions, enabling timely intervention and improved treatment outcomes.

Asan Therapeutics utilizes a novel technology that simplifies the treatment of cancer patients to receive only a single injection instead of several painful injections.

Therapeutic Vision focuses on the development of pharmaceuticals primarily for the companion animal market and eventually their owners.

US Sleep Apnea aims to combat the increasing Sleep Apnea pandemic by enlisting the help of dentists. Sleep apnea is a developing problem that will kill 48 million individuals prematurely. Dentists are perfectly positioned to solve this need; but, because this is the only medical service a dentist can provide, operational inefficiencies and expensive start-up costs have kept the majority of dentists from delivering care. The US Sleep Apnea platform provides dentists with a digital solution that automates every touchpoint in the patient experience and dramatically saves front office expenditures.

Glamorous AI develops an artificial intelligence driven drug discovery platform that accelerates pharmaceutical research by leveraging prior experimental results to identify and optimize chemical scaffolds, predict activities, and screen ultra-large chemical libraries. The platform addresses low-data, sparse, and noisy datasets, enabling the discovery of novel compounds and potential therapeutics.

AcousticaBio develops technologies to reformulate intravenous biologics for subcutaneous delivery. Its advanced fluid processing platform and proprietary microgel formulation enable ultra-concentrated, small-volume subcutaneous injections of typically IV therapies, empowering patients to self-administer life-saving biologics outside hospital settings. By converting IV medicines into subcutaneous formats, the company aims to reduce pain and discomfort, minimize hospital visits, and improve convenience and access to treatment.

Stemloop is a biosensor company dedicated to harnessing biological technology to meet global challenges in chemical sensing and detection. The company focuses on developing innovative, cell-free biosensing products that simplify and enhance the testing process for chemical and molecular analysis. By utilizing genetically encoded sensing mechanisms, Stemloop aims to provide accurate and scalable solutions that are both cost-effective and accessible. This approach allows medical professionals to obtain faster and more reliable test results, ultimately improving healthcare outcomes while addressing unmet needs in laboratory testing. Through its novel technology, Stemloop seeks to revolutionize the landscape of biosensing and contribute meaningfully to various sectors.

Fora Health helps patients and clinicians track health and take part in shared decision-making. The company's platform links a patient-facing smartphone app with a clinical team web interface, powering remote patient monitoring and shared decision making. Fora Health is scaled to the needs of clinical teams, configuring data collected from validated ePROs and cognitive assessments, to goal tracking, medication adherence, and side effect tracking.

Delfina is a data-driven prenatal care platform that personalizes pregnancy care to improve safety for mothers and babies. It uses a data-powered approach to uncover insights in prenatal care and to optimize interventional workflows through machine learning models. The platform creates individualized pregnancy care plans based on patient risk assessed from multiple metrics and supports early intervention, helping providers deliver equitable, cost-effective care. By integrating data across clinical, demographic, and monitoring inputs, Delfina aims to enhance decision-making, streamline workflows, and improve outcomes throughout pregnancy.

Free Dynamics is a technology company that specializes in the development of innovative electronic temperature sensors designed to operate without the need for external batteries. By utilizing a battery-free system driven by quantum dynamics, the company creates miniature and cost-effective sensors that can be integrated into every vial of essential drugs requiring strict storage conditions. This capability allows the pharmaceutical industry to effectively monitor temperature-sensitive products, safeguarding against tampering and counterfeiting while ensuring safe distribution. Additionally, the sensors have potential applications in the food industry, highlighting Free Dynamics' commitment to enhancing the integrity and safety of critical supply chains.

TissueLabs is the platform for creating organs and tissues in the lab. We offer biomaterials, equipment, and services to support tissue engineering and regenerative medicine. Our products are created to allow performing state-of-the-art research, from drug discovery to organ fabrication. Currently, we are focused on attending the academic life sciences market. In the future, our mission is to fabricate lab-grown tissues and organs, for both research and therapeutic applications.

BrightCure Ltd., established in 2019 and based in London, United Kingdom, specializes in developing probiotic-based therapies aimed at treating urinary tract infections (UTIs). The company focuses on addressing recurrent and difficult-to-treat bacterial infections, a significant health issue affecting 50% of women and 12% of men globally. BrightCure's approach involves utilizing the natural microbiome to reduce harmful bacteria and replenish beneficial bacteria in the vaginal flora, thereby boosting the immune system to promote urinary tract health. The company has garnered recognition through various competitions and accelerators, including selection for Indiebio, the world's largest biotech accelerator.

Babylat develops a compact, automated medical device designed for protein enrichment of human milk. This tabletop device enables on-site concentration of the protein fraction in hospitals, ensuring newborn babies receive sufficient protein.

Spirecut is a MedTech company specializing in patented surgical instruments for treating carpal tunnel syndrome and trigger finger via ultrasound-guided surgery. Its technique avoids skin incisions and post-operative wounds, enabling patients to resume daily activities immediately.

Leucine Rich Bio is India's pioneering genomics-based company focused on microbiome analysis. It aims to bridge uncertainties in precision medicine by studying the 'second genome', offering personalized nutritional recommendations based on intestinal microflora, with applications across various health fields.

BestHealth4U specializes in developing advanced adhesive technologies for medical applications. Their innovative solutions aim to prevent skin injuries, enhance healing, and improve overall patient health by transforming how bandages, dressings, and medical devices adhere to the skin.

Digi.Bio develops software and automation platforms for the healthcare and life sciences sector. The company creates digital microfluidics and electrowetting-based automation software to streamline multistep liquid handling in laboratories, replacing traditional pipetting robots. It operates a lab-on-a-chip and computational platform that analyzes cell therapies, evaluating performance and outcomes at the single-cell level to deliver high-content results quickly with minimal material waste. The company uses artificial intelligence to rapidly and precisely manipulate droplets on a microscale, enabling automated workflows for medical and pharmaceutical applications and the scaling of bioengineering processes. It is based in Amsterdam, Netherlands.

Founded in Italy in 2016 by Silvia Scaglione and Maurizio Aiello, React4life is a biotech company dedicated to advancing biomedical research. The company specializes in the development of MIVO®, an innovative organ-on-a-chip technology that enhances the reliability and predictability of various applications such as pharmaceutical drug testing, personalized medicine, immuno-oncology therapies, cosmetics, dermatology, and nutraceuticals.

FermBiotics is a microbiome company focused on improving gut health through natural, fermented seaweed and plant ingredients for food, dietary supplements, and medical foods for humans and animals. It develops sustainable fermented inputs that combine prebiotics, probiotics, and bioactives to support gut barrier function by stabilizing microflora, reducing inflammation, and strengthening the intestinal lining. The company's products are designed as ingredients for food, dietary supplements, and medical nutrition, enabling clients to incorporate gut-friendly components across various applications.

Kobara Medical specializes in developing innovative medical therapeutic devices aimed at addressing heart failure with preserved ejection fraction (HFpEF), a condition where the heart struggles to fill its main pumping chamber effectively. This condition affects over three million people and is growing. The company's unique, minimally invasive device leverages the heart's transverse pericardial sinus for neuromodulation therapies, providing an alternative to traditional cardiac rhythm management methods that often require multiple leads or invasive procedures. By utilizing this approach, Kobara Medical offers a novel solution that combines multiple leads into one, enabling multi-chamber pacing from outside the blood vessels.

Diagnoly develops an AI-powered medical device that analyzes fetal ultrasound examinations in real-time, assisting doctors in detecting complex fetal pathologies.

Epios personalized and precision management of brain disorders using daily life monitoring and therapeutics. The Epios system comprises a series of thin leads incorporating sensing electrodes and a miniature implant, inserted beneath the skin. The neural signals are wirelessly transmitted to an external receiver held in place on the skin directly over the implant with a magnet, and from there are conveyed to a wearable data processor and are finally securely stored in the Epios Cloud.