National Science Foundation

The National Science Foundation (NSF) is an independent federal agency established in 1950 and based in Alexandria, Virginia. It is dedicated to supporting research and education in science and engineering across a wide range of disciplines. The NSF provides significant non-dilutive funding, up to $1.5 million, to startups and small businesses through its America's Seed Fund initiative, which is part of the Small Business Innovation Research (SBIR) program mandated by Congress. With an operating budget of approximately $7.8 billion, the NSF is committed to advancing fundamental research and education, thus fostering innovation and technological development in the United States.

James Donlon

Program Director

Hayes, Kenneth B.

Innovation Corps (I-Corps) Adjunct Instructor

Sethuraman Panchanathan

Director

Past deals in Life Science

University of Oregon

Grant in 2023
For over a century, the University of Oregon (UO) has provided students with innovative academic programs. The large, main campus is located in Eugene, and other sites are available in Portland and Charleston (Oregon Institute of Marine Biology). The school even has the Pine Mountain Observatory in Central Oregon, operated by astronomers and UO physics students. UO’s academics offer hundreds of undergraduate and graduate degree programs including: Biochemistry, Business Administration, Interior Architecture, Marine Biology, and Music Education. It even has pre-professional programs in Clinical Laboratory Science, Occupational Therapy, Social Work, Teacher Education, and Veterinary Medicine. Study abroad programs for academic credit are available as well. Admissions materials for the school can be submitted online along with the required application fee. Applications are evaluated based on academic potential, grades, standardized test scores, extracurricular activities, and other considerations. Financial aid is awarded to those who qualify to assist with tuition costs and other educational expenses. Tuition fees are discounted for Oregon residents. College life at UO is full of opportunities: Greek Life, student-run clubs and organizations, recreational activities, sports, and more. The school is also well known for its athletic teams, the Oregon Ducks, who compete in the PAC-12. The football team in particular has built a large fan base, and students can be found at the stadium every home game Saturday during the season. For exceptional academics in a traditional university setting located near the natural beauty of the Pacific Northwest, take a look at the University of Oregon.

BioSuperior

Grant in 2022
BioSuperior is a preclinical stage biotherapeutics company developing cost-effective, non-invasive, and easily accessible technologies to cure lung disease and repair damaged lung tissue. They have bio-engineered a novel synthetic pulmonary surfactant prototype, BioSurf, an essential biomaterial required for breathing and having direct therapeutic effects that will be used to deliver potent drugs that restore normal lung function.

NovoClade

Grant in 2022
NovoClade brings chemical free environmentally friendly insect control to market.

Aqua Science

Grant in 2022
Aqua Science offers a global platform of technologies and fast and reliable solutions for the testing and treatment of water. They provide research and development, custom reagent and kit manufacture, product assembly, lyophilization services, and contract manufacturing services.

Ezrabio

Grant in 2022
EzraBio provides quick and easy RNA adenylation technology, enabling ribosome profiling without limitations. They offer rapid cDNA library construction. They offer streamlined services from sample preparation to deep sequencing.

Birch Biosciences

Grant in 2022
Birch Biosciences are used in the recycling process naturally and efficiently break down plastic. Unlike traditional recycling, the process produces virgin-quality, environmentally sustainable, and cost-competitive recycled outputs, enabling a truly circular plastics economy. The proprietary platform employs artificial intelligence, bioinformatics, and high-throughput screening techniques.

Iaso Therapeutics

Grant in 2022
Iaso Therapeutics, founded in 2018 and based in East Lansing, Michigan, is a biotechnology company focused on developing vaccines aimed at improving human health and treating infectious diseases. The company’s platform is dedicated to creating vaccines for serious illnesses, including smallpox, yellow fever, and tetanus. By providing healthcare professionals with innovative technologies, Iaso Therapeutics seeks to enhance public health outcomes and address critical health challenges.

Auctus Biologics

Grant in 2022
Auctus Biologics is a pre-clinical biotechnology company that develops antibody mimetics for therapeutic and diagnostic applications.Antibodies are the most prolific biologics in clinical environments because of their ability to bind targets with high affinity and specificity. However, antibodies also carry liabilities. They are often unstable and require costly cold-chain management to reach their destinations in active form. Because of their fragility, antibodies typically cannot be used in extreme environments like the gastrointestinal tract and can require lengthy infusions to administer to patients.

MBF Therapeutics

Grant in 2021
MBF Therapeutics is a clinical-stage animal health company focusing on the development of gene-based, immunotherapeutic vaccines for use in veterinary medicine. Using proprietary vaccine platform and delivery system technology, MBF Therapeutics’ checkpoint inhibitor therapies have the potential of transforming the treatment of cancer and prevention of infectious diseases in companion animals and livestock.

Synvivia

Grant in 2021
Synvivia, Inc. is a biotechnology company founded in 2016 and based in Berkeley, California. It specializes in developing synthetic biology products, particularly ON-OFF switches for genetically engineered organisms. These protein switches can be controlled by small molecules, allowing for precise manipulation of biological functions. By integrating these switches into organisms, Synvivia aims to create engineered life forms that can be effectively used in healthcare. The company also focuses on generating biosensors that enhance enzymatic activities, facilitating easier disease diagnosis and enabling healthcare providers to deliver appropriate treatments.

Spekciton Biosciences

Grant in 2021
Spekciton Biosciences provides biophotonic measurement systems and services, such as the rapid and precise early detection of plant stress and viability, as well as biosensors to detect fast soil and water contamination.

BioSapien

Grant in 2021
BioSapien is a pre-clinical biotech company developing novel biodegradable implantable products that deliver active pharmaceutical ingredients (APIs) for oncology indications with reduced systemic side effects. The applications for this technology are currently under investigation for pancreatic cancer and lung cancer. The intended pipeline of indications is expected to expand into other cancers such as colorectal, breast, and stomach cancers. BioSapien's 3D-printed MediChip delivers FDA-approved toxic high-dose systemic therapies in a localized slow-release biodegradable mesh which is able to target tissues while improving patients' quality of care and life.

Felix Biotechnology

Grant in 2021
Felix Biotechnology is working to accelerate the deployment of novel biotherapeutics to manage infectious diseases. Felix Biotechnology's bio-therapeutics targets antibiotic-resistant bacteria to manage infectious diseases precisely and effectively, allowing healthcare professionals to manage urgent microbial challenges in human health.

Biochip Labs

Grant in 2021
Biochip Labs provides blood disorder testing for conditions like sickle cell disease and thalassemia. The company was founded in 2019 and is headquartered in Cleveland, Ohio.

Frontier Bio

Grant in 2021
Frontier Bio is creating lab-grown human tissues as an ethical replacement for animal studies and is setting the stage to eliminate the organ transplant waitlist.

Biko Biolabs

Grant in 2021
Biko Biolabs is a research company focused on the intersection of plastic waste and regenerative agriculture. The company was founded in 2020 and is based in Somerville, Massachusetts.

Ancilia Bio

Grant in 2021
Ancilia Biosciences develops engineered bacterial therapies to treat diseases linked to the microbiome. It provides and develops novel bacterial therapies that target the viral components of the microbiome to address chronic diseases across immunology and oncology indications.

BioSens8

Grant in 2021
Sensing beyond glucose to enable holistic health monitoring

Frugi Biotechnology

Grant in 2021
Frugi Biotechnology is a synthetic biology company that creates modular, paper-based, secure diagnostics for viral outbreak management. The company was founded in 2020 and is headquartered in Ames, Iowa.

Hermes Life Sciences

Grant in 2021
Hermes Life Sciences develops solutions to improve the accuracy and accessibility of blood testing at the point of care. The company was founded by Sasank Vemulapati.

inSomaBio

Grant in 2021
InSoma Bio integrates biology and materials science to solve problems in tissue engineering and regenerative medicine. It offers genetically engineer protein-based materials that can mimic the naturally found elastin found in extracellular tissues. The company also offers reconstructive plastic surgeries and injectable materials.

Partillion Bioscience

Grant in 2021
Partillion Bioscience is an early-stage life science company developing a functional single-cell analysis platform to analyze and sort single cells based on secreted proteins. The platform allows the rapid compartmentalization and analysis of millions of single cells to probe biological functions.

Lisa Health

Grant in 2021
Midday is an app that leverages AI, sensor technology, and digital therapeutics to support women on their menopause journey using personalized insights that illuminate what is happening physically and emotionally during menopause, providing the right intervention at the right time to manage menopause symptoms and promote healthy aging.

Fireline Science

Grant in 2021
Fireline Science develops educational technology products designed to drive innovation. The company was founded in 2019 and is headquartered in Tempe, Arizona.

CellDrop Biosciences

Grant in 2021
CellDrop Biosciences develops hydrogel-based point-of-care diagnostics and targeted biomaterial delivery technology. The company was established in 2017 and is headquartered in Laramie, Wyoming.

Sears Scientific

Grant in 2021
Sears Scientific provides new technologies and solutions that improve the ease-of-use and accessibility of scientific equipment, allowing researchers to more on the science and less on the instrumentation.

Kepley BioSystems

Grant in 2021
Kepley BioSystems offers ocean restorative technology to help stem the continued depletion of wild fish.

Ansa Biotechnologies

Grant in 2021
Ansa Biotechnologies is manufactured via a chemical method that has remained essentially unchanged for 35 years and has approached a plateau. Ansa Biotechnologies is developing a novel DNA synthesis technology based on enzymes that will be more fast, accurate, and clean than existing methods. The technique promises to dramatically accelerate innovation in biological research and engineering.

VeriSIM Life

Grant in 2021
VeriSIM Life is a computational bioplatform that predicts the clinical outcomes of new drugs before clinical trials. VeriSIM offers a range of translational-based solutions, customized for the pre-clinical and clinical programs. These offerings are all centered around their proven and validated BIOiSIMTM platform for small molecules, large molecules, and viruses.

CasTag Biosciences

Grant in 2021
CasTag Biosciences specializes in cell biology and regenerative medicine, focusing on revolutionizing the speed of endogenously protein analysis. The company aims to accelerate scientific discovery by offering tools that allow scientists to study novel genes in any experimental model.

Spero Therapeutics

Grant in 2021
Spero Therapeutics is developing first in class therapeutics for treatment of gram-negative infections. The company leverages a top-tier chemistry and microbiology team, an efficient virtual approach to drug development, and a focus on high potential, novel mechanisms to fill the unmet need for early stage therapeutics targeting serious bacterial infections. Its lead program addresses a novel target driving virulence and persistence of pseudomonas aeruginosa infections and other gram-negative pathogens.
Creative BioTherapeutics is a biotechnology company developing therapies for cancer and viruses. The company is changing the way that cancer and viral disease research is conducted. It focuses on the root cause of cancer affecting immune evasion and drug resistance.

BiomeSense

Grant in 2021
BiomeSense is developing the first technology platform for continuous, at-home monitoring of the human gut microbiome, transforming the ability to understand & utilize the microbiome for precision medicine. The enabling technology is the GutLab, the first “smart bathroom” system for at-home microbiome monitoring, which is combined with the MetaBiome time-series analytics platform into a single end-to-end solution. The platform allows scientists, patients, and consumers the unprecedented ability to tie microbiome changes directly to clinical outcomes in real time, revolutionizing the ability to leverage the microbiome for better health.

SKROOT Laboratory

Grant in 2020
Skroot Laboratory produces wireless sensor systems for upstream biotherapeutic process developers which allow them to make rigorous models, reduce the risk of progressing costly conditions and decrease time to market.

Seven Biosciences

Grant in 2020
Seven Biosciences provides drug discovery platforms for G-protein coupled receptors. The company, based in Davis, California, was founded by Grace Mizuno and Lin Tian.

Ionica Sciences

Grant in 2020
Ionica Sciences, Inc. is focused on developing a spectroscopy-based diagnostic platform that utilizes surface enhanced Raman scattering (SERS) technology. Founded in 2013 and headquartered in Ithaca, New York, the company aims to address urgent needs in clinical diagnostics by enabling rapid and accurate identification of vector-borne, sexually transmitted, and neurological diseases. Ionica Sciences is particularly dedicated to creating in-vitro diagnostic assays for Lyme disease and other infectious conditions, allowing medical professionals to detect biologically relevant targets such as pathogens and hormones. By improving diagnostic accuracy, the company seeks to reduce patient suffering, minimize unnecessary antibiotic use, and lower healthcare costs associated with misdiagnoses.

FloBio

Grant in 2020
FloBio develops point-of-care diagnostics for bleeding risk based on real-time blood analysis. The company was founded in 2017 and is headquartered in Philadelphia, PA.

Plexision

Grant in 2020
Plexision develops cellular biomarkers for personalized diagnosis and drug development in solid organ transplantation, and immunological disorders. Plexision's first patented product, the PleximmuneTM assay, predicts the risk of transplant rejection. The test is based on patent-pending technology to measure antigen-specific white blood cells. Testing services for transplant recipients and drug developers are provided at Plexision’s CLIA-certified, central laboratory in Pittsburgh. Plexision currently offers cell-based testing for personalized assessment of rejection risk after solid organ transplantation The Pleximmune blood test is the first such test offered for children with liver or intestine transplantation.

Ascribe Bioscience

Grant in 2020
Ascribe Bioscience develops products that enable farmers to combat crop pathogens without negative impacts on the environment. The company is currently developing a seed treatment product that acts by boosting crops’ natural defenses. Ascribe Bioscience was founded in 2017 and is headquartered in Ithaca, New York.

GRO Biosciences

Grant in 2020
GRO Biosciences is leveraging breakthrough technologies from computational protein design and synthetic biology to develop best-in-class protein therapeutics with enhanced properties. The company has established multiple genomically recoded strains of bacteria that can incorporate non-standard amino acids into proteins to confer increased potency, stability, and targeted delivery. GRO Biosciences is applying its technology platform to develop improved protein therapeutics for diabetes, growth disorders, and autoimmunity.

Inherent Biosciences

Grant in 2020
Inherent Biosciences is a molecular diagnostics company focused on transforming the trial and error approach in medicine by leveraging insights from epigenetics. The company aims to provide clarity on complex health issues by identifying dysregulation across multiple genes and pathways, which informs personalized treatment strategies. Inherent Biosciences develops innovative therapies for a range of conditions, including pain, infertility, embryo quality, autism, rheumatoid arthritis, psoriatic arthritis, fetal heart disease, and COVID-19. By translating biological discoveries into actionable insights, the company seeks to enhance patient care and improve outcomes in various medical fields.

StabiLux Biosciences

Grant in 2020
StabiLux Biosciences produces dyes. They offer a drop-in platform technology, allowing researchers to detect what was previously undetectable while enabling existing equipment to be used to its fullest potential without the need for additional parts or new software.

VaxForm

Grant in 2020
VaxForm offers vaccine product consultation and contract development services. The company was founded in 2010 and is headquartered in Lehigh Valley, Pennsylvania.
New Equilibrium Biosciences provides a platform that reveals opportunities for structure-based design by learning biophysics with AI.

A-Alpha Bio

Grant in 2020
A-Alpha Bio is a provider of cell-based tools for quantitative and high-throughput measurements of protein interactions, accelerating target discovery, library screening, and preclinical drug characterization. A-Alpha Bio utilizes its proprietary AlphaSeq technology to map protein-protein interactions at a high scale and resolution. This technology can identify and quantify interactions between thousands of protein pairs simultaneously. By providing detailed maps of protein interactions, A-Alpha Bio aids in the identification of potential drug targets and the understanding of disease mechanisms. This can significantly streamline the process of discovering new therapeutics. A-Alpha Bio is a team of synthetic biologists, structural biologists, and next-generation sequencing experts who have come together to remove this industry-wide bottleneck.

RizLab Health

Grant in 2020
Rizlab Health enables practitioners and patients to acquire full blood count readings in minutes. Founded in 2018 and is based in East Princeton.

Gaskiya Diagnostics

Grant in 2020
Gaskiya Diagnostics develops diagnostic test kits that can detect a variety of aquatic disease types by binding to the capture proteins. The company was founded in 2019 and is headquartered in Baltimore, Maryland.

RENCI

Grant in 2020
RENCI develops and deploys advanced technologies to enable research discoveries and practical innovations. RENCI collaborates with researchers, government, and industry to engage and solve problems affecting North Carolina, the United States, and the world. RENCI is a critical catalyst for data-driven discoveries that lead to improved health, a safer environment, and increased economic and business success.

Stemloop

Grant in 2020
Stemloop—The Biosensor Company™—is on a mission to unlock the power of biology to sense and respond to the world's challenges. We discover, develop, and deploy novel technology to address unmet chemical sensing and detection needs with accessible and actionable cell-free biosensors that are faster, cheaper and easier than traditional laboratory testing.
Cellulose Sciences International develops novel methods for utilizing celluloses and lignocellulosic. The headquarters of the company are in Madison, Wisconsin.

3i DIAGNOSTICS

Grant in 2020
3i DIAGNOSTICS provides technology that enables physicians to identify infectious microbes in less than minutes while leaving them intact for further testing. They help to make more informed infection-treatment decisions while practising antibiotic stewardship.

Infecho Scientific

Grant in 2020
Infecho Scientific specializes in instrumentation research and development. The company was founded in May 2017 and is headquartered in Columbia, Missouri.

A-Alpha Bio

Grant in 2020
A-Alpha Bio is a provider of cell-based tools for quantitative and high-throughput measurements of protein interactions, accelerating target discovery, library screening, and preclinical drug characterization. A-Alpha Bio utilizes its proprietary AlphaSeq technology to map protein-protein interactions at a high scale and resolution. This technology can identify and quantify interactions between thousands of protein pairs simultaneously. By providing detailed maps of protein interactions, A-Alpha Bio aids in the identification of potential drug targets and the understanding of disease mechanisms. This can significantly streamline the process of discovering new therapeutics. A-Alpha Bio is a team of synthetic biologists, structural biologists, and next-generation sequencing experts who have come together to remove this industry-wide bottleneck.

Koliber Biosciences

Grant in 2020
Koliber Biosciences provides data science services including the development of predictive models for customers and practical statistics coaching.

Rochal Industries

Grant in 2020
Rochal Industries is a research-based company that specializes in wound care and skin care. The company was founded in 1986 and is headquartered in San Antonio, Texas.

Inso Biosciences

Grant in 2020
Inso Biosciences is an early-stage biotechnology company developing hardware platforms and tools for genomic sample handling. Our patented microfluidic technology, invented and developed at Cornell University, performs high-efficiency processing of cellular material, and we are exploring applications in long-read DNA extraction, multiomic sample processing, and pathogen surveillance. To find out more, please visit our website: www.inso.bio To get in touch with us, please email: contact@inso.bio

LEAH Labs

Grant in 2020
LEAH Labs provides Car T cells for curing B-cell lymphoma cancer in dogs. Scientists at LEAH Labs use precision gene editing to reprogram T immune cells with Chimeric Antigen Receptors (CAR) in order to create CAR T cells that seek out, specifically recognize, and destroy B cell lymphoma without the off-target side effects that come with chemotherapy.

SAFEbiosense

Grant in 2020
SAFEbiosense, founded in 2019 and headquartered in The Woodlands, Texas, specializes in developing advanced biosensing and imaging systems aimed at tackling complex challenges in endotoxin detection. The company's innovative technology employs a one-dimensional photonic crystal structure within a total-internal-reflection geometry, allowing for label-free and sensitive measurements of analytes on the sensing surface. This capability enhances the accuracy of biosensing applications, thereby providing valuable tools for researchers in various fields.

BioLum Sciences

Grant in 2020
BioLum Sciences specializes in bioanalytical chemistry & medical device development centered around our core analysis platform and chemiluminescent chemistry. BioLum uses advanced chemical systems to measure biomarkers in exhaled breath condensate and blood samples. This technology empowers pharmaceutical researchers and clinicians with tools to develop and personalize treatments for patients with chronic diseases such as asthma, chronic obstructive pulmonary disease (COPD), hypertension, and heart failure. We have several medical device products in the pipeline and offer our research & development expertise in assay development and clinical biomarker measurement, with an emphasis on oxidative stress and nitric oxide signaling. With the advent of biomarker analysis for monitoring disease severity and progression (airway inflammation, lung function) there is a desire to shift towards remote patient monitoring via non-invasive biomarkers to improve treatment plans and lower overall costs on the healthcare system. Our initial programs are focused on asthma, COPD, and hypertension. Our breath analysis product, The BioSense AMD (Airway Monitoring Device), provides a ‘window into the lung’ by measuring oxidative stress biomarkers in exhaled breath condensate (EBC). Our test requires no complicated breathing maneuvers, allowing reliable at-home monitoring. These frequent, objective measurements of lung function offer significant patient benefits, provide physicians a tool to optimize treatment, and enable researchers to stratify patients in clinical trials to better understand chronic respiratory disease states. Our blood analysis product measures nitric oxide and nitrative stress metabolites in the blood using a simple finger-prick test. This point-of-care device will provide physicians, researchers, and patients with a critical gauge of endothelial function and cardiovascular health.

BioAmp diagnostics

Grant in 2020
BioAmp is working to counteract antibiotic resistance through the development of precision diagnostics, empowering physicians around the world with the information they need to treat their patients with the right antibiotic the first time.

Nexilico

Grant in 2020
Nexilico, Inc. is an early-stage startup with the mission to advance microbiome and precision medicine research and development by developing next generation of predictive, computational platforms that improve drug design and development as well as therapeutics clinical outcome.

HelioBioSys

Grant in 2020
HelioBioSys is a biotechnology company that specializes in marine cyanobacteria. The company uses marine cyanobacteria that grow on air, seawater, and sunlight. They produce a variety of complex biopolymers. HelioBioSys has developed cost-effective ways to harvest and process them into concentrated polysaccharides and hydrogels. These sustainably-derived biomaterials have applications in cosmetics, sunscreens and bioplastics.

Envivo Bio

Grant in 2020
Envivo Bio develops a non-invasive device that collects microbiome samples from all regions of the human gastrointestinal tract. The company is based in San Carlos, California.

Inso Biosciences

Grant in 2020
Inso Biosciences is an early-stage biotechnology company developing hardware platforms and tools for genomic sample handling. Our patented microfluidic technology, invented and developed at Cornell University, performs high-efficiency processing of cellular material, and we are exploring applications in long-read DNA extraction, multiomic sample processing, and pathogen surveillance. To find out more, please visit our website: www.inso.bio To get in touch with us, please email: contact@inso.bio

Hermes Life Sciences

Grant in 2019
Hermes Life Sciences develops solutions to improve the accuracy and accessibility of blood testing at the point of care. The company was founded by Sasank Vemulapati.

VivoZ Biolabs

Grant in 2019
Vivoz Biolabs develops cell culture platforms that are designed to mimic the dynamic 3D tumor microenvironment. The company aims to commercialize its layered microfluidic tissue assay, a patented technology that can be used as an ex vivo platform for drug screening and diagnosis, and a device for personalized cancer treatment.

Allied Microbiota

Grant in 2019
Allied Microbiota, LLC, is a unique biotechnology company that is developing a family of microbial products and their enzymes to break down harmful organic chemicals faster and more economically than current remediation technologies. AMB was formed based on technology developed at Columbia University which is now being developed into AMB’s launch product, PacBac. PacBac is a microbial-based remediation solution that can rapidly reduce the levels of recalcitrant contaminants in soil without having to resort to energy-intensive incineration methods, potentially disrupting the landscape of the $20B a year soil-remediation industry. We offer cost savings of up to 80% compared to existing remediation technologies and our protocol can reduce difficult contaminants like poly-chlorinated biphenyls (PCB) by 80 percent in days. The rapidity of this treatment rivals remediation approaches like expensive incineration and unlike the use of a dwindling number of classified landfills, we destroy contaminants so that they are no longer a liability. We also have an active R&D program for new strain identification and the development of new bio-products using high throughput screening, synthetic biology, proteomics, data science, and analytical chemistry.

Culture Biosciences

Grant in 2019
Culture Biosciences develops automated bio-reactor that helps biotech companies optimize their manufacturing processes and brings products to market faster. The company also builds automated tools for fermentation. It has a digital bio-manufacturing platform to enable scientists to run, monitor, and analyze bio-reactors faster than traditional approaches by robotic sample handling and cloud data monitoring and analysis. Culture Biosciences was founded in 2016 and is headquartered in San Francisco, California.

SRC Biosciences

Grant in 2019
SRC Biosciences is a science and technology company that develops, commercializes, and maintains stereology systems. The company is headquartered in Tampa, Florida.

ThinkLive!

Grant in 2019
ThinkLive! is an interactive strategy for school systems and teachers, after-school programs, foster care centers, and parents. The company was founded in 2018 and is based in Atlanta, Georgia.

Parse Biosciences

Grant in 2019
Parse Bio is a biotechnology startup company developing single-cell sequencing kit solutions for researchers. By using combinatorial cDNA barcoding within cells themselves, Parse Biosciences’s technology allows researchers to eliminate the need for complex and expensive microfluidic instruments. Additionally, the company’s technology enables samples to be fixed, frozen, and stored, allowing researchers to separate out the sample extraction from downstream library preparation steps. This capability empowers researchers to run fixed samples collected on different dates together in a single experiment, providing greater control over sample handling and reducing handling errors. Split Biosciences rebranded as Parse Biosciences in 2020. The Seattle, Washington-based biotech company was established in 2018 by Alex Rosenberg, Charlie Roco, and Georg Friedrich Seelig.

SKROOT Laboratory

Grant in 2019
Skroot Laboratory produces wireless sensor systems for upstream biotherapeutic process developers which allow them to make rigorous models, reduce the risk of progressing costly conditions and decrease time to market.

NovoClade

Grant in 2019
NovoClade brings chemical free environmentally friendly insect control to market.

Bezoar Laboratories

Grant in 2019
Bezoar Laboratories is devoted to improving the health of humans, animals, and environment with innovative microbial solutions.

Ansa Biotechnologies

Grant in 2019
Ansa Biotechnologies is manufactured via a chemical method that has remained essentially unchanged for 35 years and has approached a plateau. Ansa Biotechnologies is developing a novel DNA synthesis technology based on enzymes that will be more fast, accurate, and clean than existing methods. The technique promises to dramatically accelerate innovation in biological research and engineering.

Sasya

Grant in 2019
Sasya is a biotech company that produces functional supplements. Its products are applicable across all species including humans, companion animals, and fish.

Iaso Therapeutics

Grant in 2019
Iaso Therapeutics, founded in 2018 and based in East Lansing, Michigan, is a biotechnology company focused on developing vaccines aimed at improving human health and treating infectious diseases. The company’s platform is dedicated to creating vaccines for serious illnesses, including smallpox, yellow fever, and tetanus. By providing healthcare professionals with innovative technologies, Iaso Therapeutics seeks to enhance public health outcomes and address critical health challenges.

Ascribe Bioscience

Grant in 2019
Ascribe Bioscience develops products that enable farmers to combat crop pathogens without negative impacts on the environment. The company is currently developing a seed treatment product that acts by boosting crops’ natural defenses. Ascribe Bioscience was founded in 2017 and is headquartered in Ithaca, New York.

Lygos

Grant in 2019
Lygos is providing biotechnology solutions for today’s renewable chemical challenges. They engineer microbes to convert sugars into high-value, industrial chemicals, targeting compounds where biological production is cost-advantaged over petrochemical production. The company's throughput screening and strain construction facilitate the rapid optimization of pathways to convert cheap and renewable feedstock to high-value chemicals. Founded in 2011, Lygos is headquartered in Berkeley, California.

Sanguine

Grant in 2019
At Sanguine, our mission is to accelerate translational biomedical research by removing the barriers to patient participation. Through transparent communications, respectful patient support, and appropriate compensation, we keep patients engaged in the research process for a better patient experience and more impactful research biospecimens.

Isolere Bio

Grant in 2019
Isolere Bio is a Healthcare Company.Monoclonal antibodies make up an effective and rapidly growing class of drugs. They are also critical research tools and essential for the development of many new diagnostics. Isolere Bio was co-founded with the vision of simplifying and streamlining the purification of biotherapeutics to improve global access to these important drugs.

GRO Biosciences

Grant in 2019
GRO Biosciences is leveraging breakthrough technologies from computational protein design and synthetic biology to develop best-in-class protein therapeutics with enhanced properties. The company has established multiple genomically recoded strains of bacteria that can incorporate non-standard amino acids into proteins to confer increased potency, stability, and targeted delivery. GRO Biosciences is applying its technology platform to develop improved protein therapeutics for diabetes, growth disorders, and autoimmunity.
Soilcea is developing citrus trees with CRISPR editing that are resistant to the deadliest illnesses affecting the citrus sector. It holds exclusive licenses to patents from community universities that allow it to use CRISPR precision breeding to treat these dangerous infections.

VaxForm

Grant in 2019
VaxForm offers vaccine product consultation and contract development services. The company was founded in 2010 and is headquartered in Lehigh Valley, Pennsylvania.

Pow.bio

Grant in 2019
Pow.bio specializes in intelligent fermentation services tailored for industrial and synthetic biology applications. The company aims to transform innovative ideas into profitable products by utilizing continuous fermentation combined with advanced control methodologies. This approach allows Pow.bio to optimize fermentation processes rapidly, resulting in high yields at reduced costs. Their fermentation capabilities range from 1 to 100 liters, accommodating various microorganisms, including bacteria, yeast, and filamentous fungi. By addressing the capacity challenges in fermentation, Pow.bio seeks to empower scientists to develop sustainable alternatives that can compete with traditional, less sustainable practices.

Cybele Microbiome

Grant in 2019
Cybele Microbiome offers a proprietary platform that brings precision control to the microbiome. Its AI platform combines machine learning with cutting-edge biotechnology and proprietary data sources, to discover natural prebiotics that feeds the microbiome to make targeted natural solutions.

Nanoview Biosciences

Grant in 2018
nanoView Diagnostics Inc. (dba NanoView Biosciences), is developing proprietary products that support research, translation and delivery of precision medicine. The Company was founded on a novel technology platform that uniquely identifies and characterizes exosomes. Our high-throughput, cost-effective analysis solutions enable life science researchers to better understand the biological role of exosomes and how to utilize them as biomarkers to provide improved insight for how diseases are diagnosed, treated and monitored.

BioInfoExperts

Grant in 2018
BioInfoExperts is a provider of end-to-end molecular surveillance services for infectious disease dynamics and pathogen molecular surveillance. They offer genomic sequencing, ribonucleic acid and deoxyribonucleic acid extraction, data analytics, and cloud-based data visualizations.

Cerillo

Grant in 2018
Cerillo is a biotechnology company that removes artificial boundaries placed on researchers by traditional laboratory technologies. Founded in 2016, Cerillo is headquartered in Charlottesville, Virginia, United States.

Kepley BioSystems

Grant in 2018
Kepley BioSystems offers ocean restorative technology to help stem the continued depletion of wild fish.

Genoverde Biosciences

Grant in 2018
Genoverde Biosciences develops cell wall technology to improve lignocellulosic energy crops and produce liquid fuels from plant sugars. The company was founded in 2015 and is headquartered in Raleigh, North Carolina.

Klar Scientific

Grant in 2018
Klar Scientific specializes in spectroscopic microscopy using its patented confocal optical profile technology. It offers its Klar Mini Pro microscope, a compact, affordable instrument designed for scientists who need spectral information with high spatial resolution.

A-Alpha Bio

Grant in 2018
A-Alpha Bio is a provider of cell-based tools for quantitative and high-throughput measurements of protein interactions, accelerating target discovery, library screening, and preclinical drug characterization. A-Alpha Bio utilizes its proprietary AlphaSeq technology to map protein-protein interactions at a high scale and resolution. This technology can identify and quantify interactions between thousands of protein pairs simultaneously. By providing detailed maps of protein interactions, A-Alpha Bio aids in the identification of potential drug targets and the understanding of disease mechanisms. This can significantly streamline the process of discovering new therapeutics. A-Alpha Bio is a team of synthetic biologists, structural biologists, and next-generation sequencing experts who have come together to remove this industry-wide bottleneck.

Genetic Intelligence

Grant in 2018
Genetic Intelligence specializes in biotechnology with scientific research and development services to cure diseases and improve health.

Nanopore Diagnostics

Grant in 2018
Nanopore Diagnostics, LLC specializes in developing rapid and portable diagnostic products for bacterial infections. Founded in 2011 and based in St. Louis, Missouri, the company has created the iNDxer, a nanopore sensor designed to count dilute nucleic acid biomarkers in minimally processed samples. This technology enables the identification of RNA markers specific to pathogenic bacteria, allowing physicians to determine the presence of harmful microbes efficiently. By providing accurate diagnostics at the point of care, Nanopore Diagnostics aims to inform antibiotic treatment decisions, thereby reducing healthcare costs and combating antibiotic resistance.

Plasmonic Diagnostics

Grant in 2018
Plasmonic Diagnostics provides 3D-printed parts and a smartphone camera as the detector. They also provide time-to-detection, intrinsic signal amplification, high signal-to-noise ratio, and directional emission.

OtziBio

Grant in 2018
Otzi Bio is a biotechnology company. They are focused on developing innovative solutions for unique biopreservation problems. They utilize non-destructive chemical imaging techniques to understand the mechanism of cellular injury and inform improvements in preservation processing techniques.

Hinge Bio

Grant in 2018
Hinge Bio is a biotechnology company that specializes in leveraging its proprietary Flex-Hinge antibody platform to develop bispecific and multispecific antibodies. It features chemical ligation process technology that enables the production of therapeutic candidates with orders-of-magnitude improved affinity and specificity. The company was founded in 2015 and headquartered in Burlingame, California.

3i DIAGNOSTICS

Grant in 2018
3i DIAGNOSTICS provides technology that enables physicians to identify infectious microbes in less than minutes while leaving them intact for further testing. They help to make more informed infection-treatment decisions while practising antibiotic stewardship.
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