Novo Holdings

Amolyt Pharma specializes in peptides for the treatment of rare endocrine and metabolic disorders. Its programs include AZP-3601, a parathyroid hormone analog, for the potential treatment of hypoparathyroidism, and AZP-3404, a peptide with a new and unique mechanism of action, that may restore fat and glucose metabolism.

NodThera Limited researches and develops novel inhibitors of the NLRP3 inflammasome for the treatment of inflammatory and neuroinflammatory diseases. It develops Inflammasomes, which are multi-protein complexes to treat a range of diseases, including arthritis, atherosclerosis, Alzheimer’s disease, diabetes, and certain cancers. The company was incorporated in 2016 and is based in Little Chesterford, United Kingdom with a laboratory in Seattle, Washington; and a corporate office in Lexington, Massachusetts.

Aristea Therapeutics, Inc. operates as a clinical-stage drug development company that develops novel therapies to treat serious inflammatory diseases. The company was founded in 2018 and is based in San Diego, California.

Lysogene is a pioneer in the basic research and clinical development of gene therapy for neurodegenerative disorders . Their mission is to radically improve the health of patients suffering from incurable life threatening conditions. They do this by developing AAV vectors that have demonstrated their effectiveness in safely delivering genetic material to the central nervous system.

Biosyntia ApS operates as a biotechnology company that develops biocatalysts for the fermentation of fine chemicals. The company was incorporated in 2012 and is based in Hørsholm, Denmark.

Lava Therapeutics is a developer of a bispecific antibody platform used to engage gamma-delta T cells for the treatment of hematological and solid cancers. Its platform creates and develops next-generation γδ T cell engaging bispecific antibodies for the treatment of cancer as well as develop potent, safe, and cost-effective biopharmaceuticals that arm the immune system to recognize and destroy tumor cells that enable doctors to safely channel the immune system's response towards tumors. Lava Therapeutics was established in 2016 and is headquartered in Utrecht, The Netherlands.

Hemab is focused on the development of bispecific antibodies for the treatment of rare bleeding disorders.

Corus Pharma is a biotech and specialty drug company that focuses on respiratory and infectious diseases. In other words, it is a development stage biopharmaceutical company that focuses on the development and commercialization of novel applications and formulations of known therapeutics to treat severe respiratory diseases. The products of the company are Corus 1020 and 1030. Corus 1020 is designed to treat respiratory infections in cystic fibrosis patients, using an inhalable form of an antibiotic called aztreonam. Corus 1030 is inhaled lidocaine for the treatment of patients suffering from the severe persistent forms of asthma. Corus Pharma is a U.S.-based company that was founded in 2001 and the company was acquired by Gilead Sciences on October 22, 2006.

Founded in 2006, MDLIVE, formerly MDLiveCare, is a telehealth provider of online and on-demand healthcare delivery services and software that benefit patients, hospitals, employers, payers, physician practice groups, and accountable care organizations.

Curza Global, LLC develops drugs for the treatment of infectious diseases and oncology. It offers novel therapeutics to control antibiotic-resistant bacteria. The company offers Ribosomal Antibiotic Program that develops antibiotics for ESKAPE pathogens that includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species, and Escherichia coli; and oncology program for diagnosing cancer. In addition, it also develops antibiofilm antibiotics that kill and eradicates the bacteria in the biofilm phenotype. Curza Global, LLC was incorporated in 2013 and is based in Salt Lake City, Utah. It has additional offices in Cambridge, Massachusetts.

Galera Therapeutics, Inc., a clinical stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the transformation of radiotherapy in cancer. The company’s lead product candidate is avasopasem manganese (GC4419), a small molecule dismutase mimetic, which is in Phase III clinical trial for the treatment of radiation-induced severe oral mucositis in patients with head and neck cancer, as well as in Phase IIa clinical trial for the treatment of radiotherapy-induced esophagitis in patients with lung cancer. It is also involved in developing GC4711, which is in Phase I/II clinical trial for the treatment of pancreatic and lung cancers. The company was founded in 2012 and is headquartered in Malvern, Pennsylvania.

LanzaTech, Inc., a carbon recycling company, produces fuel ethanol from renewable non-food resources that include industrial flue gases and other waste gases, such as those produced from the gasification of municipal solid waste and waste biomass. The company also develops bio-catalytic toolkits for gas fermentation microbe. The company was incorporated in 2005 and is based in Skokie, Illinois. It has additional offices in Roselle, Illinois; Shanghai, China; and Gurgaon, India.

F2G Ltd develops novel therapies to treat fungal diseases. It primarily focuses on developing an F3 series of anti-mold compound, which is an antifungal agent. The company offers orotomides that are antifungal agents against Aspergillus and other filamentous molds. F2G Ltd was formerly known as Functional Fungal Genomics Ltd and changed its name to F2G Ltd in July 1999. F2G Ltd was founded in 1998 and is based in Manchester, United Kingdom.

Hemab is focused on the development of bispecific antibodies for the treatment of rare bleeding disorders.

NeuroTherapeutics Pharma, Inc., a biopharmaceutical company, develops therapeutics for patients suffering from central nervous system disorders. It focuses on epilepsy, neuropathic, and acute pain disorders of the nervous system. The company was incorporated in 2006 and is based in Chicago, Illinois.

STipe Therapeutics focuses on harnessing the innate immune system to battle cancer. The company has developed first-in-class drugs targeting intracellular protein-protein interactions of the STING Pathway; a major driver of innate immunity, and regulator of tumorigenesis and autoimmune disorders. The company has identified and validated compounds that sensitizes the STING pathway and by this modulates the tumor microenvironment to support a potent anti-tumoral response.

iRhythm provides innovative and cost-effective diagnostic monitoring solutions that facilitate early diagnosis and treatment decisions, with the goal of ultimately improving patient health outcomes and reducing wasteful healthcare spending. Its flagship product, the Zio® Patch, is designed to optimize and simplify the diagnosis of cardiac arrhythmias. Zio® Patch is the smallest, lightest, least conspicuous cardiac arrhythmia diagnostic available and is indicated for up to 14-day monitoring.

Draupnir Bio intends to develop a new type of cholesterol-lowering medicine that prevents blood clots in the heart more effectively than the current medicine. The company is developing a platform for exploring the glycome to develop novel therapeutics, based on array technology, protein chemistry, and advanced carbohydrate chemistry. The company is able to synthesize, screen, and select highly potent and specific heparan sulfate glycomimetic drug candidates in cardiovascular, inflammatory, and infectious diseases.

Avalyn Pharma is a biopharma company that advances therapies for the treatment of Idiopathic Pulmonary Fibrosis (IPF) and other severe respiratory diseases. Its therapies rapidly advance AP01 for the treatment of IPF, provides additional pipeline candidates for IPF, improve the care and outcomes of severe respiratory diseases, and develop novel inhaled therapeutics. Avalyn Pharma was established in 2011 and is headquartered in Seattle, Washington.

Alentis Therapeutics AG develops and manufactures medications to treat advanced liver diseases. It develops medications for liver fibrosis, cirrhosis, and liver cancer. The company was founded in 2019 and is based in Basel, Switzerland.

Vestjysk Bank A/S is a regional bank. The bank provides a range of banking products and financial services to private and corporate customers. Its product portfolio comprises credit cards, savings accounts, mortgages, loans, pension funds, insurance, financing, leasing, as well as related advisory and investment services, among others. The bank operates an online banking facility, named Netbank, which offers access to payments, transfers, electronic invoices, product overviews, mobile banking, and securities trading.

Cardeas Pharma is developing a novel antibiotic formulation of two drugs with synergistic activity against all relevant, highly resistant Gram-negative bacilli, including Pseudomonas aeruginosa, Acinetobacter baumannii, and carbapenem-resistant Enterobacteriaceae. In addition, this antibiotic formulation has activity on biofilms. The combination also has activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA). This formulation is administered using a single-patient use, vibrating-plate nebulizer that is compatible with all ventilators. The nebulizer creates small, uniform aerosol droplets that deliver drug to the small airways and alveoli. Integration of this novel antibiotic formulation and device has the potential to achieve significant clinical outcomes relative to current standard therapy.

Disc Medicine is led by an experienced team of scientists and industry experts, and supported by a panel of advisors with a strong track record of discovering and developing new and innovative therapies. Disc Medicine was founded by Atlas Venture and Brian MacDonald, with Novo Ventures and Access Biotechnology joining as additional investors.

Unchained Labs is a developer of life science biologics tools designed to help researchers break free from tools that just don't cut it. It offers a multiplex protein stability platform for biologics that measures a host of protein stability parameters. The company's products include protein sizing systems, stability quantifiers, benchtop workflow solutions, automated buffer exchanges, concentration liberators, particle identifiers, and more, enabling biologics researchers to speed up their work with ease. Unchained Labs was established in 2013 and is based in Pleasanton, California, USA.

Karus Therapeutics Limited is a biopharmaceutical company that develops medicines for cancer. Its portfolio includes orally-active small molecule drugs, including KA2237, a dual-selective inhibitor of PI3K isoforms, such as p110ß and p110d for treating hematological and solid tumors; and KA2507 (HDAC6) for PD-L1 expressing tumors. The company was incorporated in 2005 and is based in Oxfordshire, United Kingdom.

Forendo Pharma is a developer of novel drugs intended for the treatment of urological and other endocrinological diseases.The company's drugs are competent in tissue specific hormone mechanisms for the treatment of broader gynecological conditions and Fispemifene, a novel SERM, enabling medical companies to improve the treatment of male urological conditions and giving new opportunities to unmet needs in women's and men's health.

Rappta Therapeutics Oy engages in developing anti-cancer drugs that activate protein phosphatase 2A (PP2A). Protein phosphatase 2A (PP2A) is a critical enzyme regulating protein de-phosphorylation and tumor growth. The company was incorporated in 2019 and is based in Helsinki, Finland with an additional office in the United States.

Spinifex is backed by a syndicate of experienced life science investors including Novo Ventures, Canaan Partners, GBS Venture Partners, Brandon Capital Partners, Uniseed and UniQuest. Founded in 2005, Spinifex raised an initial AU$3.25 million in Series A fundraising and a total of AU$23.08 in Series B funding support the further development of EMA401. Spinifex raised a US$45 million in a Series C round led by Novo Ventures and including additional new investor Canaan Partners in 2014. Spinifex has a strong portfolio of intellectual property around its lead compound EMA01, follow on candidates and the use of AT2 receptor antagonists to treat both neuropathic & inflammatory pain and restore nerve conduction velocity deficits, including granted US, European, Japanese, Chinese, Australian and New Zealand patents.

TheraXyte BioScience is a biotechnology company focused on extracellular vesicle (EV)-mediated drug delivery and novel EV-based therapeutics. It aims to establish a multifunctional EV-based drug delivery platform that can meet the upcoming challenges of various therapeutic applications, driving EV research from the lab bench to the bedside, and making a positive impact on human health by overcoming unsolved challenges with novel EV-based therapeutics. TheraXyte has developed and continuously upgraded its EV-based drug delivery platform, TAXY, which could enable the mass production of modifiable EVs at the GMP manufacturing level, has the capability of effectively payload packaging, and target organs/cells of interest where payload drug molecules/active biological molecules could be effectively released as therapeutics.

Macrophage Pharma is an immuno-oncology company focused on the discovery and development of novel therapies designed to enhance anti-tumour immune responses. The company’s technology platform is designed to deliver small molecule drugs to tumour associated macrophages in a highly selective manner to activate the body’s natural immune system to fight cancer.

Minervax is pursuing the development of a vaccine against Group B streptococcus (GBS) infections by utilizing a particular fusion protein, which has proved to elicit good protective immunity. A vaccine including this fusion protein will likely elicit protective immunity against many clinically relevant GBS strains.

Checkmate Pharmaceuticals, Inc., a biotechnology company, develops novel immunotherapies for the treatment of cancer. It engages in the field of CpG oligonucleotides and validates an approach that combines the ability of CpG DNA to activate an anti-tumor T-cell response with checkpoint inhibition to overcome a tumor’s ability to mute the immune response. The company has strategic alliances with Merck KGaA and Pfizer. Checkmate Pharmaceuticals, Inc. was incorporated in 2015 and is based in Cambridge, Massachusetts.

Ray Therapeutics is a company that creates novel optogenetic gene therapies for patients with blinding diseases. The company develops technology to study and learn about rare retinal diseases, allowing doctors to cure and treat inherited retinal diseases using optogenetics.

Minervax is pursuing the development of a vaccine against Group B streptococcus (GBS) infections by utilizing a particular fusion protein, which has proved to elicit good protective immunity. A vaccine including this fusion protein will likely elicit protective immunity against many clinically relevant GBS strains.

Kebotix, Inc. develops an artificial intelligence (AI) based platform for discovering new chemicals and materials. It offers Kebotix, a platform that combines artificial intelligence and robotic automation to discover chemicals and materials to improve public health, sustainability, and eliminating the production of hazardous substances through green chemistry solutions. The company’s platform provides its partners technology access to its digital research and development solutions and materials innovation programs. The company was incorporated in 2017 and is based in Cambridge, Massachusetts.

Acesion Pharma is a developer of medical drugs designed for the treatment of atrial fibrillation. The company's medical drugs develop treatments for atrial fibrillation which is the most common type of cardiac arrhythmia by following the concept of inhibiting a type of ion channel in heart cells that is involved in generating the electrical signals that regulate the heart's rhythm, providing consumers with chronic treatment to prevent the recurrence of AF and maintain normal heart rhythm.

Nuevolution A/S operates as a biopharmaceutical company focused on developing drug treatments for human diseases within oncology and chronic inflammatory diseases. The company was founded in 2001 and is based in Copenhagen, Denmark. Nuevolution A/S operates as a subsidiary of Nuevolution AB (publ)

NMD Pharma is a small molecule drug discovery company that develops novel treatments of neuromuscular disorders. Research by the founders working on the neuromuscular junction identified an approach that has not previously been exploited but shows great promise. Importantly, the approach improves neuromuscular transmission in a way that is potentially applicable to a range of clinical indications and orphan human diseases that have profound unmet medical need.

Unchained Labs is a developer of life science biologics tools designed to help researchers break free from tools that just don't cut it. It offers a multiplex protein stability platform for biologics that measures a host of protein stability parameters. The company's products include protein sizing systems, stability quantifiers, benchtop workflow solutions, automated buffer exchanges, concentration liberators, particle identifiers, and more, enabling biologics researchers to speed up their work with ease. Unchained Labs was established in 2013 and is based in Pleasanton, California, USA.

Bolt Biotherapeutics, Inc., a biotechnology company, develops immune-stimulating antibody conjugates (ISAC) for treating cancer. The company’s Boltbody platform includes ISAC and conjugates tumor-targeting antibodies to powerful immune stimulants, such as TLR agonists that convert cold tumors into immunologically hot tumors, as well as eliminates tumors. The company develops BDC-1001 as a monotherapy for patients with HER2-expressing solid tumors. Bolt Biotherapeutics, Inc. was formerly known as Bolt Therapeutics, Inc. and changed its name to Bolt Biotherapeutics, Inc. in July 2015. The company was incorporated in 2015 and is based in Redwood City, California.

Minervax is pursuing the development of a vaccine against Group B streptococcus (GBS) infections by utilizing a particular fusion protein, which has proved to elicit good protective immunity. A vaccine including this fusion protein will likely elicit protective immunity against many clinically relevant GBS strains.

Galecto, Inc. develops small molecules for the treatment of severe diseases, including fibrosis and cancer. The company, founded in 2011, builds on more than 10 years of research centering on the role of galectin-3 and LOXL-2, and the use of modulators of these proteins to treat fibrosis-related diseases and cancer. Combined with a strong patent estate, these assets give Galecto a unique therapeutic platform.

Inventiva Pharma is a clinical-stage biopharmaceutical company focused on the development of oral small molecule therapies for the treatment of patients with significant unmet medical needs in the areas of fibrosis, lysosomal storage disorders and oncology. They have built a pipeline backed by a discovery engine with an extensive library of proprietary molecules, a wholly-owned research and development facility and a team with significant expertise and deep experience in the development of compounds that target nuclear receptors, transcription factors and epigenetic modulation. Leveraging these assets and expertise, they are advancing two clinical candidates in three indications, as well as a deep pipeline of earlier stage programs.

Otonomy was founded in 2008 by Avalon Ventures and experts in the otology field in order to build the premier company dedicated to the treatment of otic disorders via localized drug delivery. This approach has already been widely adopted for the delivery of short-acting antibiotics to treat otitis media through a tympanostomy tube. In addition, otolaryngologists have demonstrated that the injection of steroids into the middle ear cavity can provide a therapeutic effect for patients with acute inner ear disorders such as Ménière’s disease and sudden sensorineural hearing loss. Expansion of this effort holds great promise for the treatment of chronic hearing loss, severe vertigo, and even tinnitus. The key to Otonomy's leading position in this nascent field is the development of a proprietary formulation platform that provides sustained drug exposure from a single administration. Broad application of this technology has already been established across a number of therapeutic classes and from these, three product candidates have been advanced into development.

Acesion Pharma is a developer of medical drugs designed for the treatment of atrial fibrillation. The company's medical drugs develop treatments for atrial fibrillation which is the most common type of cardiac arrhythmia by following the concept of inhibiting a type of ion channel in heart cells that is involved in generating the electrical signals that regulate the heart's rhythm, providing consumers with chronic treatment to prevent the recurrence of AF and maintain normal heart rhythm.

Disc Medicine is led by an experienced team of scientists and industry experts, and supported by a panel of advisors with a strong track record of discovering and developing new and innovative therapies. Disc Medicine was founded by Atlas Venture and Brian MacDonald, with Novo Ventures and Access Biotechnology joining as additional investors.

Exscientia is applying AI and big data processing to accelerate drug discovery and development. At the forefront of small molecule drug discovery. They are the first company to automate drug design, surpassing conventional human endeavor. Their AI-driven systems actively learn best practice from vast repositories of discovery data and are further enhanced with knowledge acquired from seasoned drug hunters. With better information to hand than any researcher could acquire individually, their knowledge-driven systems design millions of novel, project-specific compounds and pre-assess each for predicted potency, selectivity, ADME and other key criteria. From this, a selection of the best, information-rich compounds are selected for synthesis and assay. With new experimental data generated, the results are integrated and the next design cycle initiated. Rapid design-make-test cycles ensure unparalleled progress towards desired project goals. Exscientia has already delivered exceptional productivity, generating candidates in roughly one-quarter of the time of traditional approaches.

Shanghai ZhenGe Biotechnology Co.,Ltd. researches and develops drugs. It also engages in mammalian cell line development, upstream development, downstream development, and formulation development for various protein therapeutics. In addition, the company provides contract development and manufacturing services; and offers IND and BLA filing services. Further, it provides platform for research and development of antibodies, transient infection, process development, N-Glycosylation, and CAR-T. Shanghai ZhenGe Biotechnology Co.,Ltd. was founded in 2017 and is based in Shanghai, China.

NREP is a leading Nordic private equity real estate firm focused on generating superior risk-adjusted returns for institutional investors by working with thematic value-add investment strategies and hands-on active asset management. NREP has to date focused predominantly on modern logistics, necessity driven retail, self-storage and residential. The firm was established in 2005 and has since then raised 12 funds and executed over 240 transactions of which approx. half has been realised. NREP has over 140 dedicated professionals of whom about half are transaction or asset management professionals. The firm is managed and fully owned by its team of partners with backgrounds from top tier real estate firms, management consultancies and investment banks. A key distinctive feature of the firm is the strength and depth of the local teams; built on the premise that a fully local approach is required to identify and best exploit the different opportunities that are present across the Nordic region. NREP has maintained an office in each of its core markets of Denmark, Sweden and Finland since the start and also opened an office in Norway in 2015. In addition, the firm considers real estate to be a truly operational business in which active tenant relationship management and hands-on asset management are core disciplines, and has as such chosen to keep asset management in-house. NREP seeks to generate risk-adjusted returns for its investors, typically through the acquisition of stable, income generating assets and application of active asset management to further drive value creation; thus the Firm is able to maintain an emphasis on capital preservation, whilst ensuring potential to achieve significant upside. The Firm applies a thematic approach to sector selection, targeting market segments that are benefiting, or expected to benefit, from strong underlying supply and demand imbalances and solid operational fundamentals. In addition, NREP focuses on segments that are poorly understood or difficult for broader pools of capital to access, and so are typically relatively uncrowded or non-professional, frequently enabling the Firm to acquire stable cash flows at attractive prices and / or realise untapped value potential through applying active asset management. NREP has a track record of success through the economic cycle, consistently outperforming relevant benchmarks every year and achieving an average +20% IRR on its investments since inception with no single year of losses. The firm currently has total assets under management of €4 billion.

Numab Therapeutics AG, an oncology-focused biopharmaceutical company, designs and develops bio therapeutics for the treatment of severe diseases. Its pipeline includes inflammatory bowel disease, immuno-oncology, autoimmunity, inflammation, immuno-oncology, and multi specific immuno-oncology drugs. The company was founded in 2011 and is based in Wädenswil, Switzerland.

IO Biotech ApS is a clinical stage biotech company developing disruptive immune therapies i.e. checkpoint/cancer vaccines. Checkpoint/cancer vaccines suppress the function of regulatory immune cells and induce inflammation in the microenvironment in addition to direct targeting of cancer cells.

Aristea Therapeutics, Inc. operates as a clinical-stage drug development company that develops novel therapies to treat serious inflammatory diseases. The company was founded in 2018 and is based in San Diego, California.

Symphogen is the leader in developing recombinant polyclonal antibodies (rpAb), a new class of biopharmaceuticals for the treatment or prophylaxis of serious human diseases.

Milestone Pharmaceuticals Inc., a biopharmaceutical company, develops and commercializes etripamil for the treatment of cardiovascular indications. It is developing etripamil, a novel channel blocker, which is in Phase III clinical trial for the treatment of paroxysmal supraventricular tachycardia in the United States and Canada, as well as for the treatment of atrial fibrillation, angina, and other cardiovascular indications. The company was founded in 2003 and is headquartered in Montréal, Canada.

At Outpost, they are committed to developing novel therapeutics for the treatment of gastrointestinal and urologic disorders. The company's lead clinical-stage product candidate is in development for the treatment of overactive bladder (OAB) and irritable bowel syndrome (IBS).

Myco Works LLC researches, designs, and manufactures leather material made of natural mycelium. The company's product, Reishi, is a water-resistant material made from natural fiber that grows with customizable textures and other features. The company was founded in 2013 and is based in Indianapolis, Indiana.

Envirotainer AB is engaged in the production, development, and rental of active temperature-controlled containers for air transportation of temperature-sensitive healthcare products in Sweden and internationally. It also provides various services, including laboratory testing, qualification and validation support, data collection and reporting, and the Qualified Envirotainer Program for training. The company’s client list includes pharmaceutical and biotech companies. The company was founded in 1986 and is based in Upplands Väsby, Sweden with operations centers in Singapore; Dallas, Texas; Frankfurt, Germany; and Toronto, Canada. It also has a network stations in Hyderabad, India.

F2G Ltd develops novel therapies to treat fungal diseases. It primarily focuses on developing an F3 series of anti-mold compound, which is an antifungal agent. The company offers orotomides that are antifungal agents against Aspergillus and other filamentous molds. F2G Ltd was formerly known as Functional Fungal Genomics Ltd and changed its name to F2G Ltd in July 1999. F2G Ltd was founded in 1998 and is based in Manchester, United Kingdom.

ProteinSimple is part of the Protein Platforms division of Bio-Techne (NASDAQ: TECH). They rethinking protein tools and helping thousands of researchers around the world resolve their protein analysis problems so they can reveal new insight into proteins and their role in disease. Their wide-ranging portfolio of tools includes everything from immunoassay systems that quantify protein expression to systems that probe the structure and purity of protein-based therapeutics.

ConvaTec is a global medical products and technologies company focused on therapies for the management of chronic conditions, with leading market positions in advanced wound care, ostomy care, continence and critical care, and infusion devices. ConvaTec products provide a range of clinical and economic benefits including infection prevention, protection of at-risk skin, improved patient outcomes and reduced total cost of care.

Doctor Anywhere is a Singapore-based telehealth company that provides on demand healthcare solutions to help you lead happier, healthier lives. Their digital platform gives you quick access to health and wellness solutions, wherever you are. Their platform makes healthcare simple, seamless and convenient, and is optimised to help you manage your health in a way that best suits your lifestyle needs. With technology, better health outcomes are more achievable than ever before. They recognize modern-day struggles and are dedicated to improving healthcare services to suit our evolving lifestyle preferences.

Cirius Therapeutics, Inc., a clinical-stage pharmaceutical company, focuses on the development and commercialization of therapies for the treatment of liver and metabolic diseases. Its lead product candidate MSDC-0602K, is an oral small molecule that is in Phase 2b clinical trial being developed to treat nonalcoholic steatohepatitis with fibrosis. Cirius Therapeutics, Inc. was formerly known as Octeta Therapeutics, LLC and changed its name to Cirius Therapeutics, Inc. in March 2017. The company was founded in 2015 and is headquartered in San Diego, California.

Camel-IDS develops radiopharmaceuticals for cancer patients. Its product, CAM-H2, treats HER2 positive cancers. It also engages in clinical development to treat breast cancer patients; and develops compounds for other cancer indications. The company was incorporated in 2014 and is based in Brussels, Belgium.

XENON® is a biopharmaceutical company focused on the development of novel medicines through the application of our proprietary discovery platform, which we refer to as Extreme Genetics. Our product candidates are based on genetic insights derived from our research of families where individuals exhibit severe traits, or phenotypes. We apply our expertise to predict which phenotypes are caused by single-gene defects. By identifying and characterizing the single-gene defects responsible for such severe phenotypes, we gain valuable insights into their function in human biology and their potential as drug targets. Given that these targets are often involved in diseases beyond the rare genetic disorders in which they are first identified, we are developing proprietary product candidates to treat both orphan as well as more prevalent diseases

Inozyme is a provider of therapies for rare diseases of calcification affecting soft tissues and bone created to offer potentially disease-modifying therapies to help children who are affected with rare, but severe and debilitating disorders of metabolism. The company's enzyme replacement therapy provides the treatment of Generalized Arterial Calcification of Infancy (GACI) and Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2), enabling patients to treat diseases characterized by mineral imbalances in the body.

Logical Therapeutics, Inc., a biopharmaceutical company, engages in the development of drugs to treat diseases caused by or associated with excessive inflammation. Its products include LT-NS001, a non-steroidal anti-inflammatory drug for the treatment of chronic inflammatory conditions, such as osteoarthritis; Leptin, a hormone for the regulation of normal body mass and metabolism; and TNF, a hormone that promotes the proliferation of hepatocytes. The company was founded in 2005 and is based in Waltham, Massachusetts.

NodThera Limited researches and develops novel inhibitors of the NLRP3 inflammasome for the treatment of inflammatory and neuroinflammatory diseases. It develops Inflammasomes, which are multi-protein complexes to treat a range of diseases, including arthritis, atherosclerosis, Alzheimer’s disease, diabetes, and certain cancers. The company was incorporated in 2016 and is based in Little Chesterford, United Kingdom with a laboratory in Seattle, Washington; and a corporate office in Lexington, Massachusetts.

NMD Pharma is a small molecule drug discovery company that develops novel treatments of neuromuscular disorders. Research by the founders working on the neuromuscular junction identified an approach that has not previously been exploited but shows great promise. Importantly, the approach improves neuromuscular transmission in a way that is potentially applicable to a range of clinical indications and orphan human diseases that have profound unmet medical need.

CymaBay Therapeutics is a clinical-stage biopharmaceutical company located in the San Francisco Bay Area focused on the development and commercialization of proprietary new medicines for important human diseases. We are committed to developing breakthrough medicines that improve the lives of patients and their families. CymaBay was seeded with the assets from an earlier metabolic disease company in which more than $120M was invested to produce a robust pipeline. Arhalofenate is a novel oral small molecule being developed to treat the approximately 1 million gout patients that flare three or more times per year. Gout flares are painful inflammatory episodes caused by crystals of monosodium urate (MSU) that result from excess serum uric acid (sUA). In three Phase 2 studies in gout patients arhalofenate was shown to reduce the incidence and duration of flares while simultaneously lowering sUA. If confirmed in additional clinical studies, arhalofenate’s dual acting profile would be unique since all other urate lowering therapies paradoxically increase flares as they lower sUA over the first 6 to 12 months of treatment. Increased flares lead many patients to stop or avoid treatment leading to progression of disease with pain and suffering, erosion of joint structure and functionality, lost time from work, and increased healthcare costs.

Amira Pharmaceuticals is a small molecule pharmaceutical company focused on the discovery and early development of new drugs to treat inflammatory disease. Their discovery team is building on unparalleled insights into bioactive lipid pathways and complex signaling processes controlling many conditions including asthma, chronic obstructive pulmonary disease, cardiovascular and fibrotic diseases.

Rgenix is a a discovery platform, revolutionizing the treatment of cancer by generating the first-in-class therapeutics that target key nodes in cancer progression. Its proprietary discovery platform is based on innovations in cancer biology that enable the identification and validation of novel post-transcriptionally regulated targets. Rgenix’s productive approach has yielded multiple novel targets to date across several cancer types for which the company is developing drugs, and its scientific approach has led to the discovery of novel therapeutic targets and first-in-class drugs for several cancer subtypes, including melanoma, colorectal cancer, and triple-negative breast cancer, among others. Its aim is to discover and develop safe, effective, and commercially viable therapies that will transform the lives of cancer patients by treating metastatic disease.

Cabrellis Pharmaceuticals Corporation, a specialty pharmaceutical company developing therapies for the treatment of cancer. Cabrellis plans to initiate three separate clinical trials in small cell lung cancer (SCLC) in 2006. The first trial, designed to assess the safety and efficacy of Calsed(TM) in reference to topotecan in the second-line treatment of patients with SCLC who previously responded to platinum-based chemotherapy, is currently underway at multiple clinical trial sites in the United States.

Edgewise Therapeutics, Inc., a biopharmaceutical company, develops small molecule therapies for musculoskeletal diseases. It offers a precision medicine muscle platform that generates programs to address various muscle disorders, such as Duchenne, Becker, and limb girdle muscular dystrophies. The company develops a pipeline of precision medicine product candidates that target key muscle proteins and modulators to address genetically defined muscle disorders. Edgewise Therapeutics, Inc. was founded in 2017 and is headquartered in Boulder, Colorado.

Sonion A/S design and manufacturing of advanced miniature components and solutions.

Inthera Bioscience is a Switzerland-based private biopharmaceutical company developing targeted small molecule therapies for solid tumors. It is focused on developing inhibitors of intracellular protein-protein interactions employing a proprietary technology platform. The company is headquartered in Zürich, Switzerland.

Forendo Pharma is a developer of novel drugs intended for the treatment of urological and other endocrinological diseases.The company's drugs are competent in tissue specific hormone mechanisms for the treatment of broader gynecological conditions and Fispemifene, a novel SERM, enabling medical companies to improve the treatment of male urological conditions and giving new opportunities to unmet needs in women's and men's health.

Metagenomi, Inc. develops gene editing systems for the treatment of genetic diseases. The company was incorporated in 2016 and is based in Emeryville, California.

Thesan Pharmaceuticals, Inc. is a preclinical biopharmaceutical company dedicated to the development of novel therapeutics for disorders of the skin. Until recently, there has been comparatively limited innovation in the field of dermatology, where many companies have focused on the reformulation of existing drugs often resulting in marginal patient benefit. In contrast, Thesan is focused on the discovery and development of New Chemical Entities that have the potential to provide significantly improved treatment options to patients.

Glionova AB, a development stage biopharmaceutical company, is engaged in the development of therapies for difficult-to-treat cancers. The company develops GLN-1001, an orally bioavailable small molecule that induces selective cell death in glioblastoma cells without causing harm to normal brain tissue. Its GLN-1001 is used to treat patients suffering from glioblastoma (a common and aggressive primary brain tumor). The company also focuses on market its product through strategic partnerships with global oncology focused pharmaceutical companies. Glionova AB was founded in 2014 and is based in Stockholm, Sweden.

Arcellx, Inc. develops format for T cell-mediated anti-tumor therapy. Arcellx, Inc. was formerly known as Encarta Therapeutics, Inc. The company was incorporated in 2014 and is based in Germantown, Maryland.

Freeline Therapeutics is a biotechnology company that develops liver directed gene therapies for bleeding disorders and other diseases. Its therapies are based on next-generation proprietary AAV vector platform, with its lead program being a gene therapy to treat haemophilia B.

Vantia Ltd, a pharmaceutical company, develops small molecule drugs targeting various medical needs. Its products include Fedovapagon (VA106483), a small molecule drug candidate for the treatment of nocturia, a common condition that causes sufferers to wake frequently during the night in order to urinate. The company also provides VA111913, a small molecule drug for the treatment of dysmenorrhea, a condition caused by abnormal contractions of the uterus and constriction of uterine blood vessels during menstruation that causes abdominal cramping and pain. Vantia Ltd was incorporated in 2007 and is based in Southampton, United Kingdom.

The Protein Brewery is a high-tech company that specializes in developing and making animal-free- based protein in a sustainable way. It's a spin-out from BioscienZ and is commercializing innovative protein production using fermentation. It was founded by Wim de Laat in 2019 and is based in Breda, Noord-Brabant, The Netherlands.

Praxis Precision Medicines offers drug development services. The company was formerly known as EpiPM Therapeutics. The company was incorporated in 2015 and is based in Cambridge, Massachusetts.

Ophthotech Corporation, a biopharmaceutical company, develops various therapeutics to treat diseases of the eye. It is developing Fovista, which has completed Phase IIb clinical trials for use in combination with anti-VEGF drugs for the treatment of wet age-related macular degeneration (wet AMD); and ARC1905, a potent and selective inhibitor of complement factor C5 that has completed Phase I/IIa clinical trials to treat wet AMD. The company was founded in 2007 and is headquartered in New York, New York.

ADCendo ApS is a biotech company dedicated to developing new types of anti-cancer drugs. We focus on antibody-drug conjugates (ADCs) directed at novel targets, that have been found to be overexpressed by several cancer forms, that are all characterized by a significant unmet need for novel treatment.

Creating novel bispecific antibodies that activate the immune system to fight cancer

Adenium Biotech ApS, a biopharmaceutical company, develops and commercializes antibiotics for the treatment of gram-negative bacterial infections. The company specializes in solutions for the treatment of hospital acquired infections, such as complicated urinary tract infections and hospital acquired pneumonia caused by multiresistant gram-negative bacteria. It offers Arenicin, an anti-microbial peptide against gram-negative pathogens for pneumonia, urinary tract infection, and acinetobacter baumanii. Adenium Biotech ApS was founded in 2011 and is based in Copenhagen, Denmark.

Inthera Bioscience is a Switzerland-based private biopharmaceutical company developing targeted small molecule therapies for solid tumors. It is focused on developing inhibitors of intracellular protein-protein interactions employing a proprietary technology platform. The company is headquartered in Zürich, Switzerland.

Verona Pharma is a biotechnology company dedicated to discovering new drugs for the treatment of chronic respiratory diseases, such as asthma, allergic rhinitis (hay fever), chronic obstructive pulmonary disease (COPD) and cough.

Freeline Therapeutics is a biotechnology company that develops liver directed gene therapies for bleeding disorders and other diseases. Its therapies are based on next-generation proprietary AAV vector platform, with its lead program being a gene therapy to treat haemophilia B.

Glycomine, Inc. develops nanomedicines for rare genetic disorders. It focuses on genetic disorders of protein and lipid glycosylation, which often cause severe debilitation in patients. The company was incorporated in 2014 and is based in San Carlos, California.

Chromologics ApS develops bio-based solutions for natural food colorants. It offers ChromoRed, a new generation food colorants that replaces the current natural red food colorants, such as carmine and betanin. The company was founded in 2017 and is based in Søborg, Denmark.

Esco Lifesciences Group provides enabling technologies, products, and services for the life sciences and healthcare industries, supporting academic research and scientific discoveries, clinical practice, as well as biopharmaceutical R&D and manufacturing.

Kate Farms, Inc. produces vegan foods and drinks. It offers meal replacement shakes and tube feeding solutions. The company sells its products through a network of retail stores in the United States, as well as online. Kate Farms, Inc. was founded in 2011 and is headquartered in Santa Barbara, California with an additional office in Waltham, Massachusetts.

Hummingbird Bioscience uses systems biology to develop insights into disease biology and applies computationally guided platforms to discover and engineer breakthrough biotherapeutics. The company is pursuing a broad pipeline of first drug candidates across multiple challenging targets with strong biological validation and disease association, including lead assets: HMBD-001, an anti-HER3 antibody, and HMBD-002, an anti-VISTA antibody, for the treatment of cancer. Hummingbird has established strategic collaborations with Cancer Research UK and Amgen, and has been awarded a product development grant from the Cancer Prevention and Research Institute of Texas.

Serentis develops medical products and drugs. Its products include SRD441, a novel compound that targets endogenous pro-inflammatory and staphylococcus aureus-derived proteases; and SRD174, a topical product designed to produce relief of pruritus. The company’s research programs include SRD326, a topically-applied product for relief from symptoms of Raynaud’s phenomenon; and SRD285 which provides an approach to wound care, promoting enhanced wound healing and local analgesia. Serentis was founded in 2006 and is based in Cambridge, United Kingdom.